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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:manoalide
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Accession:CHEBI:66666 term browser browse the term
Definition:A sesterterpenoid isolated from the marine sponge Luffariella variabilis and which has been shown to exhibit inhibitory activity towards phospholipase A2.
Synonyms:exact_synonym: (5R)-5-hydroxy-4-{(2R,6R)-6-hydroxy-5-[(3E)-4-methyl-6-(2,6,6-trimethylcyclohex-1-en-1-yl)hex-3-en-1-yl]-3,6-dihydro-2H-pyran-2-yl}furan-2(5H)-one
 related_synonym: Formula=C25H36O5;   InChI=1S/C25H36O5/c1-16(10-12-20-17(2)8-6-14-25(20,3)4)7-5-9-18-11-13-21(29-23(18)27)19-15-22(26)30-24(19)28/h7,11,15,21,23-24,27-28H,5-6,8-10,12-14H2,1-4H3/b16-7+/t21-,23-,24-/m1/s1;   InChIKey=FGJIDQWRRLDGDB-CPIXEKRISA-N;   SMILES=C\\C(CCC1=C(C)CCCC1(C)C)=C/CCC1=CC[C@@H](O[C@H]1O)C1=CC(=O)O[C@H]1O
 xref: CAS:75088-80-1;   KEGG:C17156;   LIPID_MAPS_instance:LMPR0105020001
 xref_mesh: MESH:C045673
 xref: PMID:10101221;   PMID:10437157;   PMID:22394195;   PMID:25584012;   PMID:2586492;   PMID:3997864;   PMID:8149454;   Patent:CA1297030;   Patent:US4839385;   Reaxys:10729444;   Wikipedia:Manoalide


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manoalide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1b interleukin 1 beta multiple interactions ISO manoalide inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:7575673 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO manoalide inhibits the reaction [[Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; manoalide inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein] CTD PMID:7575673 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO manoalide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:7575673 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        biochemical role 19281
          metabolite 19262
            manoalide 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic ester 14073
                                        lactone 5978
                                          gamma-lactone 1214
                                            butenolide 361
                                              manoalide 3
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