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ONTOLOGY REPORT - ANNOTATIONS
Term:malic acid
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Accession:CHEBI:6650 term browser browse the term
Definition:A 2-hydroxydicarboxylic acid that is succinic acid in which one of the hydrogens attached to a carbon is replaced by a hydroxy group.
Synonyms:related_synonym: 2-Hydroxybutanedioic acid;   2-Hydroxyethane-1,2-dicarboxylic acid;   2-Hydroxysuccinic acid;   Aepfelsaeure;   DL-Malic acid;   E296;   Formula=C4H6O5;   H2mal;   InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9);   InChIKey=BJEPYKJPYRNKOW-UHFFFAOYSA-N;   SMILES=OC(CC(O)=O)C(O)=O;   alpha-hydroxysuccinic acid;   apple acid;   hydroxybutanedioic acid;   hydroxysuccinic acid
 xref: Beilstein:1723539 "Beilstein";   CAS:6915-15-7 "ChemIDplus";   CAS:6915-15-7 "NIST Chemistry WebBook";   Gmelin:3325 "Gmelin";   HMDB:HMDB0000744;   KEGG:C00711;   KEGG:D04843
 xref_mesh: MESH:C030298
 xref: MetaCyc:RS-Malate;   PMID:15767321 "Europe PMC";   PMID:17190852 "Europe PMC";   PMID:17439666 "Europe PMC";   PMID:17896933 "Europe PMC";   PMID:19743855 "Europe PMC";   PMID:22411507 "Europe PMC";   PPDB:1352;   Reaxys:1723539 "Reaxys";   Wikipedia:Malic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:15595;   is_conjugate_acid_of CHEBI:25115

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malic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 JBrowse link 1 141,874,354 141,893,674 RGD:6480464
G Mdh1 malate dehydrogenase 1 JBrowse link 14 106,378,349 106,393,642 RGD:6480464
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 JBrowse link 7 30,003,429 30,162,095 RGD:6480464
G Ppargc1a PPARG coactivator 1 alpha JBrowse link 14 63,095,291 63,190,688 RGD:6480464
diethyl malate term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acta2 actin alpha 2, smooth muscle JBrowse link 1 252,537,614 252,550,394 RGD:6480464
G Actc1 actin, alpha, cardiac muscle 1 JBrowse link 3 105,507,403 105,512,939 RGD:6480464
G Actn3 actinin alpha 3 JBrowse link 1 220,120,532 220,136,460 RGD:6480464
G Adcy1 adenylate cyclase 1 JBrowse link 14 87,311,970 87,429,880 RGD:6480464
G Adh1 alcohol dehydrogenase 1 (class I) JBrowse link 2 243,550,655 243,562,243 RGD:6480464
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:6480464
G C3 complement C3 JBrowse link 9 9,721,137 9,747,084 RGD:6480464
G Cacnb2 calcium voltage-gated channel auxiliary subunit beta 2 JBrowse link 17 81,673,862 82,019,219 RGD:6480464
G Cacnb4 calcium voltage-gated channel auxiliary subunit beta 4 JBrowse link 3 37,950,846 38,211,478 RGD:6480464
G Camk2a calcium/calmodulin-dependent protein kinase II alpha JBrowse link 18 56,193,978 56,295,869 RGD:6480464
G Ccl20 C-C motif chemokine ligand 20 JBrowse link 9 88,918,359 88,921,017 RGD:6480464
G Ccl6 chemokine (C-C motif) ligand 6 JBrowse link 10 70,798,118 70,802,750 RGD:6480464
G Ccl7 C-C motif chemokine ligand 7 JBrowse link 10 69,423,083 69,424,933 RGD:6480464
G Col11a1 collagen type XI alpha 1 chain JBrowse link 2 216,863,423 217,056,523 RGD:6480464
G Col2a1 collagen type II alpha 1 chain JBrowse link 7 139,454,945 139,484,403 RGD:6480464
G Col3a1 collagen type III alpha 1 chain JBrowse link 9 52,023,295 52,059,221 RGD:6480464
G Col6a1 collagen type VI alpha 1 chain JBrowse link 20 12,657,913 12,676,370 RGD:6480464
G Comp cartilage oligomeric matrix protein JBrowse link 16 20,798,437 20,807,070 RGD:6480464
G Cxcl12 C-X-C motif chemokine ligand 12 JBrowse link 4 149,261,044 149,273,891 RGD:6480464
G Cxcl3 C-X-C motif chemokine ligand 3 JBrowse link 14 18,820,168 18,839,659 RGD:6480464
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 JBrowse link 5 119,546,458 119,564,843 RGD:6480464
G Dapk2 death-associated protein kinase 2 JBrowse link 8 71,822,107 71,941,941 RGD:6480464
G Ddx58 DEXD/H-box helicase 58 JBrowse link 5 56,486,584 56,536,898 RGD:6480464
G Dhrs3 dehydrogenase/reductase 3 JBrowse link 5 162,809,090 162,843,385 RGD:6480464
G Dhx58 DEXH-box helicase 58 JBrowse link 10 88,599,722 88,611,562 RGD:6480464
G Edar ectodysplasin-A receptor JBrowse link 20 28,179,132 28,263,092 RGD:6480464
G Ednra endothelin receptor type A JBrowse link 19 33,928,356 33,991,703 RGD:6480464
G Epas1 endothelial PAS domain protein 1 JBrowse link 6 10,306,508 10,385,239 RGD:6480464
G Epha7 Eph receptor A7 JBrowse link 5 43,602,744 43,761,198 RGD:6480464
G Ephb2 Eph receptor B2 JBrowse link 5 155,024,478 155,143,539 RGD:6480464
G Ephb6 Eph receptor B6 JBrowse link 4 70,903,253 70,918,514 RGD:6480464
G Fgf10 fibroblast growth factor 10 JBrowse link 2 51,673,480 51,747,533 RGD:6480464
G Fgf18 fibroblast growth factor 18 JBrowse link 10 18,047,109 18,082,290 RGD:6480464
G Fgfr2 fibroblast growth factor receptor 2 JBrowse link 1 200,590,951 200,696,946 RGD:6480464
G Fst follistatin JBrowse link 2 46,537,589 46,544,813 RGD:6480464
G Fzd2 frizzled class receptor 2 JBrowse link 10 90,550,147 90,552,057 RGD:6480464
G Fzd7 frizzled class receptor 7 JBrowse link 9 66,305,731 66,308,550 RGD:6480464
G Gclc glutamate-cysteine ligase, catalytic subunit JBrowse link 8 85,059,051 85,097,471 RGD:6480464
G Gclm glutamate cysteine ligase, modifier subunit JBrowse link 2 225,827,504 225,847,876 RGD:6480464
G Ggt6 gamma-glutamyl transferase 6 JBrowse link 10 58,995,253 58,998,431 RGD:6480464
G Gli2 GLI family zinc finger 2 JBrowse link 13 34,829,021 35,049,172 RGD:6480464
G Gnao1 G protein subunit alpha o1 JBrowse link 19 11,513,201 11,669,578 RGD:6480464
G Gng7 G protein subunit gamma 7 JBrowse link 7 11,565,740 11,629,519 RGD:6480464
G Gsr glutathione-disulfide reductase JBrowse link 16 62,197,617 62,239,987 RGD:6480464
G Gss glutathione synthetase JBrowse link 3 151,076,254 151,106,557 RGD:6480464
G Gsta2 glutathione S-transferase alpha 2 JBrowse link 8 85,640,081 85,645,621 RGD:6480464
G Gsta3 glutathione S-transferase alpha 3 JBrowse link 9 27,357,490 27,417,023 RGD:6480464
G Gsta6 glutathione S-transferase alpha 6 JBrowse link 9 27,475,273 27,533,939 RGD:6480464
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 JBrowse link 2 181,045,694 181,103,321 RGD:6480464
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 JBrowse link 2 180,976,939 181,026,001 RGD:6480464
G Hck HCK proto-oncogene, Src family tyrosine kinase JBrowse link 3 148,579,917 148,623,026 RGD:6480464
G Hgf hepatocyte growth factor JBrowse link 4 15,435,460 15,505,377 RGD:6480464
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:6480464
G Il15 interleukin 15 JBrowse link 19 23,542,606 23,624,366 RGD:6480464
G Il18 interleukin 18 JBrowse link 8 55,009,666 55,016,286 RGD:6480464
G Irf7 interferon regulatory factor 7 JBrowse link 1 214,249,388 214,252,909 RGD:6480464
G Isg15 ISG15 ubiquitin-like modifier JBrowse link 5 173,624,862 173,629,124 RGD:6480464
G Itga11 integrin subunit alpha 11 JBrowse link 8 67,566,874 67,683,973 RGD:6480464
G Itga3 integrin subunit alpha 3 JBrowse link 10 82,855,841 82,887,755 RGD:6480464
G Kcnmb4 potassium calcium-activated channel subfamily M regulatory beta subunit 4 JBrowse link 7 59,461,808 59,514,759 RGD:6480464
G Lama1 laminin subunit alpha 1 JBrowse link 9 115,916,907 116,042,123 RGD:6480464
G Lama4 laminin subunit alpha 4 JBrowse link 20 44,060,715 44,201,966 RGD:6480464
G LOC100909797 RT1 class I histocompatibility antigen, AA alpha chain-like JBrowse link 20 3,242,236 3,253,995 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mrvi1 murine retrovirus integration site 1 homolog JBrowse link 1 175,681,960 175,804,737 RGD:6480464
G Myl9 myosin light chain 9 JBrowse link 3 152,857,573 152,863,961 RGD:6480464
G Odc1 ornithine decarboxylase 1 JBrowse link 6 42,852,529 42,859,142 RGD:6480464
G Pdgfb platelet derived growth factor subunit B JBrowse link 7 121,215,458 121,233,092 RGD:6480464
G Pdgfd platelet derived growth factor D JBrowse link 8 4,441,010 4,666,754 RGD:6480464
G Pf4 platelet factor 4 JBrowse link 14 18,848,549 18,849,258 RGD:6480464
G Pik3ip1 phosphoinositide-3-kinase interacting protein 1 JBrowse link 14 83,559,397 83,572,481 RGD:6480464
G Plxnc1 plexin C1 JBrowse link 7 35,848,083 36,000,969 RGD:6480464
G Prkg1 protein kinase cGMP-dependent 1 JBrowse link 1 248,982,039 250,300,952 RGD:6480464
G Ptgis prostaglandin I2 synthase JBrowse link 3 163,950,746 163,986,129 RGD:6480464
G Ramp2 receptor activity modifying protein 2 JBrowse link 10 89,166,170 89,168,962 RGD:6480464
G Rgs3 regulator of G-protein signaling 3 JBrowse link 5 78,429,017 78,567,281 RGD:6480464
G Runx1t1 RUNX1 partner transcriptional co-repressor 1 JBrowse link 5 27,284,921 27,440,802 RGD:6480464
G Sema3b semaphorin 3B JBrowse link 8 116,353,791 116,362,655 RGD:6480464
G Sema4g semaphorin 4G JBrowse link 1 264,738,935 264,753,399 RGD:6480464
G Sema5a semaphorin 5A JBrowse link 2 85,377,318 85,808,970 RGD:6480464
G Stat1 signal transducer and activator of transcription 1 JBrowse link 9 54,287,540 54,327,958 RGD:6480464
G Tgfb2 transforming growth factor, beta 2 JBrowse link 13 105,039,639 105,142,010 RGD:6480464
G Thbs1 thrombospondin 1 JBrowse link 3 109,862,120 109,873,466 RGD:6480464
G Thbs2 thrombospondin 2 JBrowse link 1 56,653,929 56,683,571 RGD:6480464
G Tnc tenascin C JBrowse link 5 79,789,686 79,874,555 RGD:6480464
G Tnfrsf11b TNF receptor superfamily member 11B JBrowse link 7 93,798,580 93,826,586 RGD:6480464
G Tnnt1 troponin T1, slow skeletal type JBrowse link 1 72,889,270 72,899,629 RGD:6480464
G Tslp thymic stromal lymphopoietin JBrowse link 18 25,613,601 25,618,066 RGD:6480464
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19754
    role 19701
      application 19353
        food additive 14662
          food acidity regulator 11570
            malic acid 93
              (R)-malic acid + 0
              (S)-malic acid + 0
              2,3-dimethylmalic acid + 0
              2-(omega-methylthio)alkylmalic acid + 0
              2-(p-coumaroyl)malic acid 0
              2-hydroxy-3-(2-methylidenecyclopropyl)butanedioic acid 0
              2-phosphinomethylmalic acid 0
              3-(omega-methylthio)alkylmalic acid + 0
              3-carboxy-3-hydroxypropanoyl-CoA 0
              malate ester + 89
Path 2
Term Annotations click to browse term
  CHEBI ontology 19754
    subatomic particle 19752
      composite particle 19752
        hadron 19752
          baryon 19752
            nucleon 19752
              atomic nucleus 19752
                atom 19752
                  main group element atom 19637
                    p-block element atom 19637
                      carbon group element atom 19528
                        carbon atom 19517
                          organic molecular entity 19517
                            organic group 18422
                              organic divalent group 18414
                                organodiyl group 18414
                                  carbonyl group 18303
                                    carbonyl compound 18303
                                      dicarboxylic acids and O-substituted derivatives 10238
                                        dicarboxylic acid 10232
                                          alpha,omega-dicarboxylic acid 2748
                                            succinic acid 206
                                              malic acid 93
                                                (R)-malic acid + 0
                                                (S)-malic acid + 0
                                                2,3-dimethylmalic acid + 0
                                                2-(omega-methylthio)alkylmalic acid + 0
                                                2-(p-coumaroyl)malic acid 0
                                                2-hydroxy-3-(2-methylidenecyclopropyl)butanedioic acid 0
                                                2-phosphinomethylmalic acid 0
                                                3-(omega-methylthio)alkylmalic acid + 0
                                                3-carboxy-3-hydroxypropanoyl-CoA 0
                                                malate ester + 89
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.