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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:malic acid
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Accession:CHEBI:6650 term browser browse the term
Definition:A 2-hydroxydicarboxylic acid that is succinic acid in which one of the hydrogens attached to a carbon is replaced by a hydroxy group.
Synonyms:related_synonym: 2-Hydroxybutanedioic acid;   2-Hydroxyethane-1,2-dicarboxylic acid;   2-Hydroxysuccinic acid;   Aepfelsaeure;   DL-Malic acid;   E296;   Formula=C4H6O5;   H2mal;   InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9);   InChIKey=BJEPYKJPYRNKOW-UHFFFAOYSA-N;   SMILES=OC(CC(O)=O)C(O)=O;   alpha-hydroxysuccinic acid;   apple acid;   hydroxybutanedioic acid;   hydroxysuccinic acid
 xref: Beilstein:1723539;   CAS:6915-15-7;   Gmelin:3325;   HMDB:HMDB0000744;   KEGG:C00711;   KEGG:D04843
 xref_mesh: MESH:C030298
 xref: MetaCyc:RS-Malate;   PMID:15767321;   PMID:17190852;   PMID:17439666;   PMID:17896933;   PMID:19743855;   PMID:22411507;   PPDB:1352;   Reaxys:1723539;   Wikipedia:Malic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:15595;   is_conjugate_acid_of CHEBI:25115

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malic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions
decreases abundance		 ISO Triazines inhibits the reaction [IDH2 protein mutant form results in decreased abundance of malic acid] CTD PMID:27469509 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705 		JBrowse link
G Mdh1 malate dehydrogenase 1 increases expression ISO malic acid deficiency results in increased expression of MDH1 mRNA CTD PMID:26811028 NCBI chr14:106,378,349...106,393,642
Ensembl chr14:106,378,942...106,393,670 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO [[NR1H4 protein co-treated with Dietary Fats] results in increased susceptibility to caffeic acid phenethyl ester] which results in increased abundance of malic acid CTD PMID:28223344 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO malic acid results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009 		JBrowse link
diethyl malate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle affects expression ISO diethyl malate affects the expression of ACTA2 mRNA CTD PMID:24814887 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394 		JBrowse link
G Actc1 actin, alpha, cardiac muscle 1 affects expression ISO diethyl malate affects the expression of ACTC1 mRNA CTD PMID:24814887 NCBI chr 3:105,507,403...105,512,939
Ensembl chr 3:105,507,403...105,512,939 		JBrowse link
G Actn3 actinin alpha 3 affects expression ISO diethyl malate affects the expression of ACTN3 mRNA CTD PMID:24814887 NCBI chr 1:220,120,532...220,136,460
Ensembl chr 1:220,120,533...220,136,470 		JBrowse link
G Adcy1 adenylate cyclase 1 affects expression ISO diethyl malate affects the expression of ADCY1 mRNA CTD PMID:24814887 NCBI chr14:87,311,970...87,429,880
Ensembl chr14:87,312,203...87,421,659 		JBrowse link
G Adh1 alcohol dehydrogenase 1 (class I) affects expression ISO diethyl malate affects the expression of ADH1 mRNA CTD PMID:24814887 NCBI chr 2:243,550,655...243,562,243
Ensembl chr 2:243,550,627...243,687,857 		JBrowse link
G Agt angiotensinogen affects expression ISO diethyl malate affects the expression of AGT mRNA CTD PMID:24814887 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433 		JBrowse link
G C3 complement C3 affects expression ISO diethyl malate affects the expression of C3 mRNA CTD PMID:24814887 NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167 		JBrowse link
G Cacnb2 calcium voltage-gated channel auxiliary subunit beta 2 affects expression ISO diethyl malate affects the expression of CACNB2 mRNA CTD PMID:24814887 NCBI chr17:81,673,862...82,019,219
Ensembl chr17:81,798,756...82,017,682 		JBrowse link
G Cacnb4 calcium voltage-gated channel auxiliary subunit beta 4 affects expression ISO diethyl malate affects the expression of CACNB4 mRNA CTD PMID:24814887 NCBI chr 3:37,950,846...38,211,478
Ensembl chr 3:37,955,069...38,090,526 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions
affects expression		 ISO S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of CAMK2A mRNA] CTD PMID:24814887 NCBI chr18:56,193,978...56,295,869
Ensembl chr18:56,193,978...56,295,869 		JBrowse link
G Ccl20 C-C motif chemokine ligand 20 affects expression ISO diethyl malate affects the expression of CCL20 mRNA CTD PMID:24814887 NCBI chr 9:88,918,359...88,921,017
Ensembl chr 9:88,918,433...88,921,001 		JBrowse link
G Ccl6 C-C motif chemokine ligand 6 affects expression ISO diethyl malate affects the expression of CCL6 mRNA CTD PMID:24814887 NCBI chr10:70,798,118...70,802,750
Ensembl chr10:70,797,124...70,802,782 		JBrowse link
G Ccl7 C-C motif chemokine ligand 7 affects expression ISO diethyl malate affects the expression of CCL7 mRNA CTD PMID:24814887 NCBI chr10:69,423,083...69,424,933
Ensembl chr10:69,423,086...69,424,979 		JBrowse link
G Col11a1 collagen type XI alpha 1 chain affects expression ISO diethyl malate affects the expression of COL11A1 mRNA CTD PMID:24814887 NCBI chr 2:216,863,423...217,056,523
Ensembl chr 2:216,863,428...217,056,523 		JBrowse link
G Col2a1 collagen type II alpha 1 chain affects expression ISO diethyl malate affects the expression of COL2A1 mRNA CTD PMID:24814887 NCBI chr 7:139,454,945...139,484,403
Ensembl chr 7:139,455,242...139,483,997 		JBrowse link
G Col3a1 collagen type III alpha 1 chain affects expression ISO diethyl malate affects the expression of COL3A1 mRNA CTD PMID:24814887 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217 		JBrowse link
G Col6a1 collagen type VI alpha 1 chain affects expression ISO diethyl malate affects the expression of COL6A1 mRNA CTD PMID:24814887 NCBI chr20:12,657,913...12,676,370
Ensembl chr20:12,658,065...12,675,561 		JBrowse link
G Comp cartilage oligomeric matrix protein affects expression ISO diethyl malate affects the expression of COMP mRNA CTD PMID:24814887 NCBI chr16:20,798,437...20,807,070
Ensembl chr16:20,798,437...20,807,070 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 affects expression
multiple interactions		 ISO diethyl malate affects the expression of CXCL12 mRNA
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of CXCL12 mRNA]		 CTD PMID:24814887 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 affects expression ISO diethyl malate affects the expression of CXCL1 mRNA CTD PMID:24814887 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595 		JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 affects expression ISO diethyl malate affects the expression of CYP2J9 mRNA CTD PMID:24814887 NCBI chr 5:119,546,458...119,564,843
Ensembl chr 5:119,546,461...119,564,846 		JBrowse link
G Dapk2 death-associated protein kinase 2 affects expression ISO diethyl malate affects the expression of DAPK2 mRNA CTD PMID:24814887 NCBI chr 8:71,822,107...71,941,941
Ensembl chr 8:71,822,129...71,941,910 		JBrowse link
G Ddx58 DEXD/H-box helicase 58 affects expression ISO diethyl malate affects the expression of DDX58 mRNA CTD PMID:24814887 NCBI chr 5:56,486,584...56,536,898
Ensembl chr 5:56,500,734...56,536,772 		JBrowse link
G Dhrs3 dehydrogenase/reductase 3 affects expression ISO diethyl malate affects the expression of DHRS3 mRNA CTD PMID:24814887 NCBI chr 5:162,809,090...162,843,385
Ensembl chr 5:162,808,646...162,843,383 		JBrowse link
G Dhx58 DEXH-box helicase 58 affects expression ISO diethyl malate affects the expression of DHX58 mRNA CTD PMID:24814887 NCBI chr10:88,599,722...88,611,562
Ensembl chr10:88,599,680...88,611,105 		JBrowse link
G Edar ectodysplasin-A receptor affects expression ISO diethyl malate affects the expression of EDAR mRNA CTD PMID:24814887 NCBI chr20:28,179,132...28,263,092
Ensembl chr20:28,179,140...28,263,037 		JBrowse link
G Ednra endothelin receptor type A affects expression ISO diethyl malate affects the expression of EDNRA mRNA CTD PMID:24814887 NCBI chr19:33,928,356...33,991,703
Ensembl chr19:33,928,356...33,991,703 		JBrowse link
G Epas1 endothelial PAS domain protein 1 affects expression ISO diethyl malate affects the expression of EPAS1 mRNA CTD PMID:24814887 NCBI chr 6:10,306,508...10,385,239
Ensembl chr 6:10,306,405...10,387,265 		JBrowse link
G Epha7 Eph receptor A7 affects expression ISO diethyl malate affects the expression of EPHA7 mRNA CTD PMID:24814887 NCBI chr 5:43,602,744...43,761,198
Ensembl chr 5:43,603,043...43,757,549 		JBrowse link
G Ephb2 Eph receptor B2 affects expression ISO diethyl malate affects the expression of EPHB2 mRNA CTD PMID:24814887 NCBI chr 5:155,024,478...155,143,539
Ensembl chr 5:155,022,493...155,204,456 		JBrowse link
G Ephb6 Eph receptor B6 affects expression ISO diethyl malate affects the expression of EPHB6 mRNA CTD PMID:24814887 NCBI chr 4:70,903,253...70,918,514
Ensembl chr 4:70,903,253...70,918,514 		JBrowse link
G Fgf10 fibroblast growth factor 10 affects expression ISO diethyl malate affects the expression of FGF10 mRNA CTD PMID:24814887 NCBI chr 2:51,673,480...51,747,533
Ensembl chr 2:51,672,722...51,750,369 		JBrowse link
G Fgf18 fibroblast growth factor 18 multiple interactions
affects expression		 ISO S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of FGF18 mRNA] CTD PMID:24814887 NCBI chr10:18,047,109...18,082,290
Ensembl chr10:18,047,109...18,063,391 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 affects expression ISO diethyl malate affects the expression of FGFR2 mRNA CTD PMID:24814887 NCBI chr 1:200,590,951...200,696,946
Ensembl chr 1:200,590,953...200,696,928 		JBrowse link
G Fst follistatin affects expression ISO diethyl malate affects the expression of FST mRNA CTD PMID:24814887 NCBI chr 2:46,537,589...46,544,813
Ensembl chr 2:46,538,700...46,544,457 		JBrowse link
G Fzd2 frizzled class receptor 2 affects expression ISO diethyl malate affects the expression of FZD2 mRNA CTD PMID:24814887 NCBI chr10:90,550,147...90,552,057
Ensembl chr10:90,550,147...90,552,057 		JBrowse link
G Fzd7 frizzled class receptor 7 affects expression ISO diethyl malate affects the expression of FZD7 mRNA CTD PMID:24814887 NCBI chr 9:66,305,731...66,308,550
Ensembl chr 9:66,305,731...66,308,550 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit affects expression ISO diethyl malate affects the expression of GCLC mRNA CTD PMID:24814887 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions
affects expression		 ISO S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GCLM mRNA] CTD PMID:24814887 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874 		JBrowse link
G Ggt6 gamma-glutamyl transferase 6 affects expression ISO diethyl malate affects the expression of GGT6 mRNA CTD PMID:24814887 NCBI chr10:58,995,253...58,998,431
Ensembl chr10:58,995,556...58,998,033 		JBrowse link
G Gli2 GLI family zinc finger 2 affects expression ISO diethyl malate affects the expression of GLI2 mRNA CTD PMID:24814887 NCBI chr13:34,829,021...35,049,172
Ensembl chr13:34,829,139...35,048,444 		JBrowse link
G Gnao1 G protein subunit alpha o1 affects expression ISO diethyl malate affects the expression of GNAO1 mRNA CTD PMID:24814887 NCBI chr19:11,513,201...11,669,578
Ensembl chr19:11,513,201...11,669,578 		JBrowse link
G Gng7 G protein subunit gamma 7 affects expression ISO diethyl malate affects the expression of GNG7 mRNA CTD PMID:24814887 NCBI chr 7:11,565,740...11,629,519
Ensembl chr 7:11,582,984...11,628,929 		JBrowse link
G Gsr glutathione-disulfide reductase affects expression ISO diethyl malate affects the expression of GSR mRNA CTD PMID:24814887 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361 		JBrowse link
G Gss glutathione synthetase multiple interactions
affects expression		 ISO S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GSS mRNA] CTD PMID:24814887 NCBI chr 3:151,076,254...151,106,557
Ensembl chr 3:151,076,254...151,106,557 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 affects expression
multiple interactions		 ISO diethyl malate affects the expression of GSTA1 mRNA
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GSTA1 mRNA]		 CTD PMID:24814887 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gsta3 glutathione S-transferase alpha 3 affects expression
multiple interactions		 ISO diethyl malate affects the expression of GSTA3 mRNA
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GSTA3 mRNA]		 CTD PMID:24814887 NCBI chr 9:27,357,490...27,417,023
Ensembl chr 9:27,402,381...27,417,023 		JBrowse link
G Gsta6 glutathione S-transferase alpha 6 affects expression
multiple interactions		 ISO diethyl malate affects the expression of GSTA1 mRNA
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GSTA1 mRNA]		 CTD PMID:24814887 NCBI chr 9:27,475,273...27,533,939
Ensembl chr 9:27,475,273...27,511,176 		JBrowse link
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 affects expression ISO diethyl malate affects the expression of GUCY1A1 mRNA CTD PMID:24814887 NCBI chr 2:181,045,694...181,103,321
Ensembl chr 2:181,045,703...181,102,918 		JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 affects expression ISO diethyl malate affects the expression of GUCY1B1 mRNA CTD PMID:24814887 NCBI chr 2:180,976,939...181,026,001
Ensembl chr 2:180,976,939...181,026,024 		JBrowse link
G Hck HCK proto-oncogene, Src family tyrosine kinase affects expression ISO diethyl malate affects the expression of HCK mRNA CTD PMID:24814887 NCBI chr 3:148,579,917...148,623,026
Ensembl chr 3:148,579,920...148,623,033 		JBrowse link
G Hgf hepatocyte growth factor affects expression ISO diethyl malate affects the expression of HGF mRNA CTD PMID:24814887 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362 		JBrowse link
G Igf1 insulin-like growth factor 1 affects expression ISO diethyl malate affects the expression of IGF1 mRNA CTD PMID:24814887 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609 		JBrowse link
G Il15 interleukin 15 affects expression ISO diethyl malate affects the expression of IL15 mRNA CTD PMID:24814887 NCBI chr19:23,542,606...23,624,366
Ensembl chr19:23,542,889...23,554,594 		JBrowse link
G Il18 interleukin 18 affects expression ISO diethyl malate affects the expression of IL18 mRNA CTD PMID:24814887 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299 		JBrowse link
G Irag1 inositol 1,4,5-triphosphate receptor associated 1 affects expression ISO diethyl malate affects the expression of IRAG1 mRNA CTD PMID:24814887 NCBI chr 1:175,681,960...175,804,737
Ensembl chr 1:175,681,960...175,796,040 		JBrowse link
G Irf7 interferon regulatory factor 7 affects expression ISO diethyl malate affects the expression of IRF7 mRNA CTD PMID:24814887 NCBI chr 1:214,249,388...214,252,909
Ensembl chr 1:214,248,837...214,252,456 		JBrowse link
G Isg15 ISG15 ubiquitin-like modifier affects expression ISO diethyl malate affects the expression of ISG15 mRNA CTD PMID:24814887 NCBI chr 5:173,624,862...173,629,124
Ensembl chr 5:173,624,310...173,626,248 		JBrowse link
G Itga11 integrin subunit alpha 11 affects expression ISO diethyl malate affects the expression of ITGA11 mRNA CTD PMID:24814887 NCBI chr 8:67,566,874...67,683,973
Ensembl chr 8:67,615,635...67,683,973 		JBrowse link
G Itga3 integrin subunit alpha 3 affects expression ISO diethyl malate affects the expression of ITGA3 mRNA CTD PMID:24814887 NCBI chr10:82,855,841...82,887,755
Ensembl chr10:82,855,613...82,887,497 		JBrowse link
G Kcnmb4 potassium calcium-activated channel subfamily M regulatory beta subunit 4 affects expression ISO diethyl malate affects the expression of KCNMB4 mRNA CTD PMID:24814887 NCBI chr 7:59,461,808...59,514,759
Ensembl chr 7:59,461,799...59,514,939 		JBrowse link
G Lama1 laminin subunit alpha 1 affects expression ISO diethyl malate affects the expression of LAMA1 mRNA CTD PMID:24814887 NCBI chr 9:115,916,907...116,042,123
Ensembl chr 9:115,916,907...116,042,123 		JBrowse link
G Lama4 laminin subunit alpha 4 affects expression ISO diethyl malate affects the expression of LAMA4 mRNA CTD PMID:24814887 NCBI chr20:44,060,715...44,201,966
Ensembl chr20:44,060,731...44,209,614 		JBrowse link
G LOC100909797 RT1 class I histocompatibility antigen, AA alpha chain-like affects expression ISO diethyl malate affects the expression of H2-M3 mRNA CTD PMID:24814887 NCBI chr20:3,242,236...3,253,995
Ensembl chr20:3,242,470...3,249,189 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 affects phosphorylation
multiple interactions		 ISO diethyl malate affects the phosphorylation of MAPK1 protein
S-ethyl glutathione inhibits the reaction [diethyl malate affects the phosphorylation of MAPK1 protein]		 CTD PMID:24814887 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 affects phosphorylation
multiple interactions		 ISO diethyl malate affects the phosphorylation of MAPK3 protein
S-ethyl glutathione inhibits the reaction [diethyl malate affects the phosphorylation of MAPK3 protein]		 CTD PMID:24814887 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Myl9 myosin light chain 9 affects expression ISO diethyl malate affects the expression of MYL9 mRNA CTD PMID:24814887 NCBI chr 3:152,857,573...152,863,961
Ensembl chr 3:152,857,592...152,863,960 		JBrowse link
G Odc1 ornithine decarboxylase 1 affects expression ISO diethyl malate affects the expression of ODC1 mRNA CTD PMID:24814887 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927 		JBrowse link
G Pdgfb platelet derived growth factor subunit B affects expression
multiple interactions		 ISO diethyl malate affects the expression of PDGFB mRNA
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of PDGFB mRNA]		 CTD PMID:24814887 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741 		JBrowse link
G Pdgfd platelet derived growth factor D affects expression ISO diethyl malate affects the expression of PDGFD mRNA CTD PMID:24814887 NCBI chr 8:4,441,010...4,666,754
Ensembl chr 8:4,440,876...4,669,014 		JBrowse link
G Pf4 platelet factor 4 affects expression ISO diethyl malate affects the expression of PF4 mRNA CTD PMID:24814887 NCBI chr14:18,848,549...18,849,258
Ensembl chr14:18,848,549...18,849,258 		JBrowse link
G Pik3ip1 phosphoinositide-3-kinase interacting protein 1 affects expression ISO diethyl malate affects the expression of PIK3IP1 mRNA CTD PMID:24814887 NCBI chr14:83,559,397...83,572,481
Ensembl chr14:83,560,541...83,572,473 		JBrowse link
G Plxnc1 plexin C1 affects expression ISO diethyl malate affects the expression of PLXNC1 mRNA CTD PMID:24814887 NCBI chr 7:35,848,083...36,000,969
Ensembl chr 7:35,850,398...36,000,906 		JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 affects expression ISO diethyl malate affects the expression of PRKG1 mRNA CTD PMID:24814887 NCBI chr 1:248,982,039...250,300,952 JBrowse link
G Ptgis prostaglandin I2 synthase affects expression ISO diethyl malate affects the expression of PTGIS mRNA CTD PMID:24814887 NCBI chr 3:163,950,746...163,986,129 JBrowse link
G Ramp2 receptor activity modifying protein 2 affects expression ISO diethyl malate affects the expression of RAMP2 mRNA CTD PMID:24814887 NCBI chr10:89,166,170...89,168,962
Ensembl chr10:89,166,890...89,168,965 		JBrowse link
G Rgs3 regulator of G-protein signaling 3 affects expression ISO diethyl malate affects the expression of RGS3 mRNA CTD PMID:24814887 NCBI chr 5:78,429,017...78,567,281
Ensembl chr 5:78,428,669...78,567,288 		JBrowse link
G Runx1t1 RUNX1 partner transcriptional co-repressor 1 affects expression ISO diethyl malate affects the expression of RUNX1T1 mRNA CTD PMID:24814887 NCBI chr 5:27,284,921...27,440,802
Ensembl chr 5:27,312,928...27,442,841 		JBrowse link
G Sema3b semaphorin 3B affects expression ISO diethyl malate affects the expression of SEMA3B mRNA CTD PMID:24814887 NCBI chr 8:116,353,791...116,362,655
Ensembl chr 8:116,354,073...116,361,343 		JBrowse link
G Sema4g semaphorin 4G affects expression ISO diethyl malate affects the expression of SEMA4G mRNA CTD PMID:24814887 NCBI chr 1:264,738,935...264,753,399
Ensembl chr 1:264,741,911...264,753,397 		JBrowse link
G Sema5a semaphorin 5A affects expression ISO diethyl malate affects the expression of SEMA5A mRNA CTD PMID:24814887 NCBI chr 2:85,377,318...85,808,970
Ensembl chr 2:85,377,318...85,808,970 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 affects expression ISO diethyl malate affects the expression of STAT1 mRNA CTD PMID:24814887 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 affects expression
multiple interactions		 ISO diethyl malate affects the expression of TGFB2 mRNA
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of TGFB2 mRNA]		 CTD PMID:24814887 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030 		JBrowse link
G Thbs1 thrombospondin 1 affects expression ISO diethyl malate affects the expression of THBS1 mRNA CTD PMID:24814887 NCBI chr 3:109,862,120...109,873,466
Ensembl chr 3:109,862,117...109,873,466 		JBrowse link
G Thbs2 thrombospondin 2 affects expression ISO diethyl malate affects the expression of THBS2 mRNA CTD PMID:24814887 NCBI chr 1:56,653,929...56,683,571
Ensembl chr 1:56,653,938...56,683,731 		JBrowse link
G Tnc tenascin C affects expression ISO diethyl malate affects the expression of TNC mRNA CTD PMID:24814887 NCBI chr 5:79,789,686...79,874,555
Ensembl chr 5:79,789,671...79,874,671 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B affects expression ISO diethyl malate affects the expression of TNFRSF11B mRNA CTD PMID:24814887 NCBI chr 7:93,798,580...93,826,586
Ensembl chr 7:93,798,545...93,826,665 		JBrowse link
G Tnnt1 troponin T1, slow skeletal type affects expression ISO diethyl malate affects the expression of TNNT1 mRNA CTD PMID:24814887 NCBI chr 1:72,889,270...72,899,629
Ensembl chr 1:72,889,270...72,899,659 		JBrowse link
G Tslp thymic stromal lymphopoietin affects expression ISO diethyl malate affects the expression of TSLP mRNA CTD PMID:24814887 NCBI chr18:25,613,601...25,618,066
Ensembl chr18:25,613,831...25,617,361 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19883
    role 19833
      application 19505
        food additive 14758
          food acidity regulator 11704
            malic acid 93
              (R)-malic acid + 0
              (S)-malic acid + 0
              2,3-dimethylmalic acid + 0
              2-(omega-methylthio)alkylmalic acid + 0
              2-(p-coumaroyl)malic acid 0
              2-hydroxy-3-(2-methylidenecyclopropyl)butanedioic acid 0
              2-phosphinomethylmalic acid 0
              3-(omega-methylthio)alkylmalic acid + 0
              3-carboxy-3-hydroxypropanoyl-CoA 0
              malate ester + 89
Path 2
Term Annotations click to browse term
  CHEBI ontology 19883
    subatomic particle 19881
      composite particle 19881
        hadron 19881
          baryon 19881
            nucleon 19881
              atomic nucleus 19881
                atom 19881
                  main group element atom 19771
                    p-block element atom 19771
                      carbon group element atom 19679
                        carbon atom 19668
                          organic molecular entity 19668
                            organic group 18580
                              organic divalent group 18571
                                organodiyl group 18571
                                  carbonyl group 18479
                                    carbonyl compound 18479
                                      dicarboxylic acids and O-substituted derivatives 10300
                                        dicarboxylic acid 10291
                                          alpha,omega-dicarboxylic acid 2784
                                            succinic acid 220
                                              malic acid 93
                                                (R)-malic acid + 0
                                                (S)-malic acid + 0
                                                2,3-dimethylmalic acid + 0
                                                2-(omega-methylthio)alkylmalic acid + 0
                                                2-(p-coumaroyl)malic acid 0
                                                2-hydroxy-3-(2-methylidenecyclopropyl)butanedioic acid 0
                                                2-phosphinomethylmalic acid 0
                                                3-(omega-methylthio)alkylmalic acid + 0
                                                3-carboxy-3-hydroxypropanoyl-CoA 0
                                                malate ester + 89
paths to the root