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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:malaoxon
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Accession:CHEBI:6649 term browser browse the term
Definition:A racemate comprising equimolar amounts of (R) and (S)-malaoxon. It is the active insecticide of the proinsecticide malathion.
Synonyms:exact_synonym: rac-diethyl 2-[(dimethoxyphosphoryl)thio]succinate
 related_synonym: Liromat;   O,O-Dimethyl S-(1,2-dicarbethoxy)ethyl phosphorothioate;   diethyl 2-dimethoxyphosphorylsulfanylbutanedioate;   dimethoxyphosphorylsulfanyl-succinic acid diethyl ester;   oxycarbophos;   rac-malaoxon
 xref: CAS:1634-78-2
 xref_mesh: MESH:C100082
 xref: PMID:26173615;   PMID:28849997;   PMID:7894269;   PMID:8292751;   PMID:8292752;   Reaxys:1804523;   Wikipedia:Malaoxon

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malaoxon term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
decreases activity		 ISO
EXP		 [malaoxon co-treated with Dichlorvos] results in decreased activity of ACHE protein; asoxime chloride inhibits the reaction [malaoxon results in decreased activity of ACHE protein]; HLo 7 inhibits the reaction [malaoxon results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [malaoxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [malaoxon results in decreased activity of ACHE protein]
malaoxon metabolite results in decreased activity of ACHE protein; malaoxon results in decreased activity of ACHE protein
Dichlorvos promotes the reaction [malaoxon results in decreased activity of ACHE protein]; K075 compound inhibits the reaction [malaoxon results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [malaoxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [malaoxon results in decreased activity of ACHE protein]; Trimedoxime inhibits the reaction [malaoxon results in decreased activity of ACHE protein]		 CTD PMID:597376, PMID:4859365, PMID:8783813, PMID:9268605, PMID:9515941, PMID:20406208, PMID:21251949, PMID:21354413, PMID:27132127, PMID:30625376 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753 		JBrowse link
G Alb albumin affects binding ISO malaoxon binds to ALB protein CTD PMID:15525694 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863 		JBrowse link
G Bche butyrylcholinesterase affects binding ISO malaoxon binds to BCHE protein; malaoxon binds to BCHE protein modified form CTD PMID:18514178 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395 		JBrowse link
G Cldn5 claudin 5 multiple interactions
decreases expression		 EXP [malaoxon co-treated with Lead] results in decreased expression of CLDN5 protein
malaoxon results in decreased expression of CLDN5 protein		 CTD PMID:20970449 NCBI chr11:86,356,292...86,357,718
Ensembl chr11:86,356,294...86,357,718 		JBrowse link
G Ocln occludin multiple interactions
decreases expression		 EXP [malaoxon co-treated with Lead] results in decreased expression of OCLN protein
malaoxon results in decreased expression of OCLN protein		 CTD PMID:20970449 NCBI chr 2:30,527,327...30,577,218
Ensembl chr 2:30,527,715...30,577,218 		JBrowse link
G Pnpla6 patatin-like phospholipase domain containing 6 decreases activity ISO malaoxon results in decreased activity of PNPLA6 protein CTD PMID:9268605 NCBI chr12:2,068,749...2,098,139
Ensembl chr12:2,069,959...2,097,904 		JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO PON1 affects the susceptibility to [diazoxon co-treated with malaoxon]; PON1 affects the susceptibility to [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate co-treated with malaoxon] CTD PMID:19371602 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372 		JBrowse link
G Tjp1 tight junction protein 1 multiple interactions
decreases expression		 EXP [malaoxon co-treated with Lead] results in decreased expression of TJP1 protein
malaoxon results in decreased expression of TJP1 protein		 CTD PMID:20970449 NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469 		JBrowse link
G Tjp2 tight junction protein 2 multiple interactions
decreases expression		 EXP [malaoxon co-treated with Lead] results in decreased expression of TJP2 protein
malaoxon results in decreased expression of TJP2 protein		 CTD PMID:20970449 NCBI chr 1:241,945,816...242,084,044
Ensembl chr 1:241,945,841...242,083,484 		JBrowse link
G Trpc1 transient receptor potential cation channel, subfamily C, member 1 increases expression EXP malaoxon results in increased expression of TRPC1 mRNA; malaoxon results in increased expression of TRPC1 protein CTD PMID:22674931 NCBI chr 8:103,503,982...103,554,905
Ensembl chr 8:103,503,985...103,554,468 		JBrowse link
G Trpc4 transient receptor potential cation channel, subfamily C, member 4 increases expression EXP malaoxon results in increased expression of TRPC4 mRNA; malaoxon results in increased expression of TRPC4 protein CTD PMID:22674931 NCBI chr 2:143,433,102...143,605,757
Ensembl chr 2:143,475,323...143,604,972 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        agrochemical 14435
          malaoxon 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      chalcogen 19360
                        oxygen atom 19321
                          oxygen molecular entity 19321
                            hydroxides 19066
                              oxoacid 18192
                                pnictogen oxoacid 10144
                                  phosphorus oxoacid 9032
                                    phosphoric acids 7794
                                      phosphoric acid 7794
                                        phosphoric acid derivative 7473
                                          phosphate 7473
                                            organic phosphate 7472
                                              organic thiophosphate 2814
                                                diethyl 2-[(dimethoxyphosphoryl)thio]succinate 11
                                                  (R)-malaoxon 11
                                                    malaoxon 11
paths to the root

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