Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:(+)-sesamin
go back to main search page
Accession:CHEBI:66470 term browser browse the term
Definition:A lignan that consists of tetrahydro-1H,3H-furo[3,4-c]furan substituted by 1,3-benzodioxole groups at positions 1 and 4 (the 1S,3aR,4S,6aR stereoisomer). Isolated from Cinnamomum camphora, it exhibits cytotoxic activity.
Synonyms:exact_synonym: 5,5'-(1S,3aR,4S,6aR)-tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diylbis(1,3-benzodioxole)
 related_synonym: Fagarol;   Formula=C20H18O6;   InChI=1S/C20H18O6/c1-3-15-17(25-9-23-15)5-11(1)19-13-7-22-20(14(13)8-21-19)12-2-4-16-18(6-12)26-10-24-16/h1-6,13-14,19-20H,7-10H2/t13-,14-,19+,20+/m0/s1;   InChIKey=PEYUIKBAABKQKQ-AFHBHXEDSA-N;   SMILES=[C@]12([C@@]([C@H](OC1)C3=CC4=C(C=C3)OCO4)(CO[C@@H]2C5=CC6=C(C=C5)OCO6)[H])[H];   Sezamin
 xref: CAS:607-80-7;   HMDB:HMDB0034256;   KEGG:C10882;   KNApSAcK:C00000601
 xref_mesh: MESH:C054125
 xref: MetaCyc:CPD-8922;   PMID:16309310;   PMID:16785429;   PMID:21043475;   PMID:21973101;   PMID:27558960;   PMID:27632923;   PMID:28157651;   PMID:28239780;   Reaxys:96118;   Wikipedia:Sesamin


show annotations for term's descendants           Sort by:
(+)-sesamin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO [sesamin affects the activity of ABCB1 protein] which results in increased abundance of Daunorubicin CTD PMID:18204840 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions EXP sesamin affects the reaction [Glucose affects the localization of AIFM1 protein] CTD PMID:22524206 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO
EXP		 sesamin inhibits the reaction [nickel sulfate results in increased expression of BAX protein]
sesamin affects the reaction [Glucose affects the expression of BAX protein]		 CTD PMID:22524206 PMID:23317420 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO
EXP		 sesamin inhibits the reaction [nickel sulfate results in decreased expression of BCL2 protein]
sesamin affects the reaction [Glucose affects the expression of BCL2 protein]		 CTD PMID:22524206 PMID:23317420 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP		 sesamin inhibits the reaction [nickel sulfate results in increased cleavage of CASP3 protein]
sesamin inhibits the reaction [Glucose results in increased cleavage of CASP3 protein]		 CTD PMID:22524206 PMID:23317420 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase decreases activity
multiple interactions		 EXP
ISO		 sesamin results in decreased activity of CAT protein
sesamin inhibits the reaction [nickel sulfate results in decreased activity of CAT protein]
sesamin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CAT protein]; sesamin inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]		 CTD PMID:19794909 PMID:23317420 PMID:26825964 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cdh1 cadherin 1 increases expression ISO sesamin results in increased expression of CDH1 mRNA; sesamin results in increased expression of CDH1 protein CTD PMID:33561518 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Ctnnb1 catenin beta 1 increases expression ISO sesamin results in increased expression of CTNNB1 mRNA; sesamin results in increased expression of CTNNB1 protein CTD PMID:33561518 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Fads1 fatty acid desaturase 1 decreases activity EXP sesamin results in decreased activity of FADS1 protein CTD PMID:14974737 NCBI chr 1:206,827,724...206,842,734
Ensembl chr 1:206,827,765...206,842,734 		JBrowse link
G Gsr glutathione-disulfide reductase increases activity EXP sesamin results in increased activity of GSR protein CTD PMID:19835851 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO sesamin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL1B mRNA]; sesamin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL1B protein] CTD PMID:22919443 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP		 sesamin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL6 mRNA]; sesamin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL6 protein] CTD PMID:19794909 PMID:22919443 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions		 EXP sesamin results in decreased expression of NOS2 protein
sesamin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NOS2 protein]		 CTD PMID:19794909 PMID:22919443 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions EXP sesamin inhibits the reaction [Glucose results in increased cleavage of PARP1 protein] CTD PMID:22524206 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [sesamin inhibits the reaction [Doxorubicin results in decreased expression of and results in decreased activity of SOD2 protein]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [sesamin results in increased expression of and results in increased activity of SOD2 protein]; sesamin inhibits the reaction [Doxorubicin results in decreased expression of and results in decreased activity of SOD2 protein]; sesamin results in increased expression of and results in increased activity of SOD2 protein CTD PMID:24211423 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP sesamin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein] CTD PMID:19794909 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO sesamin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TNF mRNA]; sesamin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TNF protein] CTD PMID:22919443 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      application 19689
        pharmaceutical 19525
          drug 19525
            antineoplastic agent 17817
              (+)-sesamin 17
                (+)-sesamin dicatechol 0
                (+)-sesamin monocatechol + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            organic molecule 19700
                              organic cyclic compound 19490
                                organic heterocyclic compound 18868
                                  organic heteropolycyclic compound 18294
                                    organic heterobicyclic compound 17237
                                      benzodioxoles 8476
                                        (+)-sesamin 17
                                          (+)-sesamin dicatechol 0
                                          (+)-sesamin monocatechol + 0
paths to the root