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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Magnolol
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Accession:CHEBI:6643 term browser browse the term
Definition:A biphenyl that has formula C18H18O2.
Synonyms:related_synonym: Formula=C18H18O2;   InChI=1S/C18H18O2/c1-3-5-13-7-9-17(19)15(11-13)16-12-14(6-4-2)8-10-18(16)20/h3-4,7-12,19-20H,1-2,5-6H2;   InChIKey=VVOAZFWZEDHOOU-UHFFFAOYSA-N;   SMILES=Oc1ccc(CC=C)cc1-c1cc(CC=C)ccc1O
 xref: CAS:528-43-8;   KEGG:C10651;   KNApSAcK:C00000591
 xref_mesh: MESH:C005498


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Magnolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme multiple interactions EXP magnolol inhibits the reaction [Monocrotaline results in increased expression of ACE protein] CTD PMID:30466619 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Ace2 angiotensin I converting enzyme 2 multiple interactions EXP magnolol inhibits the reaction [Monocrotaline results in decreased expression of ACE2 protein] CTD PMID:30466619 NCBI chr  X:32,050,734...32,095,860
Ensembl chr  X:32,049,931...32,096,016
JBrowse link
G Agt angiotensinogen multiple interactions EXP magnolol inhibits the reaction [AGT protein binds to AGTR1A protein]; magnolol inhibits the reaction [Monocrotaline results in increased expression of AGT protein] CTD PMID:30466619 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions EXP magnolol inhibits the reaction [AGT protein binds to AGTR1A protein]; magnolol inhibits the reaction [Monocrotaline results in increased expression of AGTR1A protein] CTD PMID:30466619 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Aif1 allograft inflammatory factor 1 multiple interactions ISO magnolol inhibits the reaction [trimethyltin results in increased expression of AIF1 protein] CTD PMID:26756313 NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP magnolol inhibits the reaction [Monocrotaline results in increased phosphorylation of AKT1 protein] CTD PMID:30466619 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO magnolol inhibits the reaction [trimethyltin results in increased expression of BAX protein] CTD PMID:26756313 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO magnolol inhibits the reaction [trimethyltin results in decreased expression of BCL2 protein] CTD PMID:26756313 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO magnolol inhibits the reaction [trimethyltin results in increased expression of CASP3 protein modified form]
magnolol results in increased activity of CASP3 protein
CTD PMID:26756313 PMID:31714653 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 increases activity ISO magnolol results in increased activity of CASP9 protein CTD PMID:31714653 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase increases activity EXP magnolol results in increased activity of CAT protein CTD PMID:31708532 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO magnolol results in decreased expression of CCND1 protein CTD PMID:31714653 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ces1d carboxylesterase 1D multiple interactions ISO magnolol binds to and results in decreased activity of CES1 protein CTD PMID:31170387 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Ces2h carboxylesterase 2H multiple interactions ISO magnolol binds to and results in decreased activity of CES2 protein CTD PMID:31170387 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP magnolol inhibits the reaction [Monocrotaline results in increased expression of CTNNB1 protein] CTD PMID:30466619 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO magnolol results in decreased activity of CYP1A2 protein CTD PMID:19140158 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Edn1 endothelin 1 multiple interactions EXP magnolol inhibits the reaction [Monocrotaline results in increased expression of EDN1 protein] CTD PMID:30466619 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Ednra endothelin receptor type A multiple interactions EXP magnolol inhibits the reaction [Monocrotaline results in increased expression of EDNRA protein] CTD PMID:30466619 NCBI chr19:33,928,356...33,991,703
Ensembl chr19:33,928,356...33,991,703
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO magnolol inhibits the reaction [trimethyltin results in increased expression of GFAP protein] CTD PMID:26756313 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Glo1 glyoxalase 1 multiple interactions EXP magnolol inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein] CTD PMID:28919305 NCBI chr20:9,273,589...9,291,608
Ensembl chr20:9,273,594...9,291,610
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions EXP magnolol promotes the reaction [Pyruvaldehyde results in increased expression of GPX1 mRNA] CTD PMID:28919305 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP magnolol inhibits the reaction [Monocrotaline results in increased phosphorylation of GSK3B protein] CTD PMID:30466619 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO magnolol inhibits the reaction [trimethyltin results in increased expression of HMOX1 protein] CTD PMID:26756313 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP magnolol inhibits the reaction [Pyruvaldehyde results in decreased expression of IL1B protein] CTD PMID:28919305 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Ins2 insulin 2 multiple interactions EXP magnolol inhibits the reaction [Pyruvaldehyde results in decreased expression of INS2 mRNA] CTD PMID:28919305 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
EXP
ISO
magnolol inhibits the reaction [Monocrotaline results in increased phosphorylation of MAPK1 protein]
magnolol results in decreased phosphorylation of MAPK1 protein
CTD PMID:30466619 PMID:31714653 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
EXP
ISO
magnolol inhibits the reaction [Monocrotaline results in increased phosphorylation of MAPK3 protein]
magnolol results in decreased phosphorylation of MAPK3 protein
CTD PMID:30466619 PMID:31714653 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO magnolol inhibits the reaction [trimethyltin results in increased phosphorylation of MAPK8 protein] CTD PMID:26756313 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO magnolol inhibits the reaction [trimethyltin results in increased phosphorylation of MAPK9 protein] CTD PMID:26756313 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO magnolol results in decreased expression of MMP9 protein CTD PMID:31714653 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO magnolol inhibits the reaction [trimethyltin results in increased phosphorylation of NFKBIA protein] CTD PMID:26756313 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
magnolol inhibits the reaction [trimethyltin results in increased expression of NOS2 protein]
magnolol inhibits the reaction [Monocrotaline results in increased expression of NOS2 protein]
CTD PMID:26756313 PMID:30466619 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP magnolol inhibits the reaction [Monocrotaline results in decreased expression of NOS3 protein] CTD PMID:30466619 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity EXP magnolol results in increased activity of NQO1 protein CTD PMID:31708532 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 multiple interactions EXP [magnolol co-treated with Pyruvaldehyde] results in increased expression of PDX1 mRNA CTD PMID:28919305 NCBI chr12:9,496,044...9,501,211
Ensembl chr12:9,496,044...9,501,213
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [magnolol binds to and results in increased activity of PPARG protein]; magnolol binds to and results in increased activity of PPARG protein CTD PMID:20064974 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions EXP [magnolol co-treated with Pyruvaldehyde] results in increased expression of PPARGC1A protein CTD PMID:28919305 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression ISO magnolol results in decreased expression of RELA protein CTD PMID:31714653 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP [magnolol co-treated with Pyruvaldehyde] results in increased expression of SIRT1 protein CTD PMID:28919305 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 affects localization EXP magnolol affects the localization of SREBF1 protein CTD PMID:19371623 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO magnolol inhibits the reaction [trimethyltin results in increased secretion of TNF protein] CTD PMID:26756313 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 decreases activity ISO magnolol results in decreased activity of UGT1A9 protein CTD PMID:26875642 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO magnolol results in decreased expression of VEGFA protein CTD PMID:31714653 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO magnolol results in decreased expression of XIAP protein CTD PMID:31714653 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19767
    chemical entity 19767
      molecular entity 19766
        polyatomic entity 19685
          molecule 19526
            cyclic compound 19359
              ring assembly 7264
                biphenyls 6009
                  Magnolol 44
Path 2
Term Annotations click to browse term
  CHEBI ontology 19767
    subatomic particle 19766
      composite particle 19766
        hadron 19766
          baryon 19766
            nucleon 19766
              atomic nucleus 19766
                atom 19766
                  main group element atom 19657
                    p-block element atom 19657
                      carbon group element atom 19573
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19496
                              organic cyclic compound 19322
                                carbocyclic compound 18299
                                  benzenoid aromatic compound 17404
                                    biphenyls 6009
                                      Magnolol 44
paths to the root