|
G |
Abcc5 |
ATP binding cassette subfamily C member 5 |
multiple interactions |
ISO |
[xanthohumol binds to and results in decreased activity of ABCC5 protein] which results in decreased export of Hyaluronic Acid; xanthohumol binds to and results in decreased activity of ABCC5 protein; xanthohumol inhibits the reaction [ABCC5 protein results in increased export of Hyaluronic Acid] |
CTD |
PMID:23978416 |
|
NCBI chr11:84,395,982...84,490,215
Ensembl chr11:84,396,033...84,490,211
|
|
G |
Akt2 |
AKT serine/threonine kinase 2 |
multiple interactions |
ISO |
xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of AKT2 mRNA] |
CTD |
PMID:23994090 |
|
NCBI chr 1:84,400,939...84,451,223
Ensembl chr 1:84,411,726...84,450,162
|
|
G |
Alpl |
alkaline phosphatase, biomineralization associated |
increases activity increases expression |
ISO |
xanthohumol results in increased activity of ALPL protein xanthohumol results in increased expression of ALPL mRNA |
CTD |
PMID:16019205 |
|
NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
EXP |
xanthohumol inhibits the reaction [Azoxymethane results in decreased expression of BAX protein] |
CTD |
PMID:31714664 |
|
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression multiple interactions |
ISO EXP |
xanthohumol results in decreased expression of BCL2; xanthohumol results in decreased expression of BCL2 protein xanthohumol inhibits the reaction [Azoxymethane results in increased expression of BCL2 protein] |
CTD |
PMID:15995977 PMID:23562496 PMID:26297991 PMID:31714664 |
|
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
|
|
G |
Car2 |
carbonic anhydrase 2 |
multiple interactions |
ISO |
xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of CAR2 mRNA] |
CTD |
PMID:23994090 |
|
NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
|
|
G |
Casp3 |
caspase 3 |
multiple interactions decreases activity increases activity |
ISO EXP |
xanthohumol results in increased cleavage of and results in increased activity of CASP3 protein xanthohumol inhibits the reaction [Azoxymethane results in decreased expression of CASP3 protein] xanthohumol results in decreased activity of CASP3 protein xanthohumol results in increased activity of CASP3 protein |
CTD |
PMID:15995977 PMID:26297991 PMID:27317025 PMID:30240731 PMID:31714664 |
|
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
|
|
G |
Casp7 |
caspase 7 |
multiple interactions increases activity |
ISO |
xanthohumol results in increased cleavage of and results in increased activity of CASP7 protein xanthohumol results in increased activity of CASP7 protein |
CTD |
PMID:15995977 PMID:30240731 |
|
NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
|
|
G |
Casp8 |
caspase 8 |
multiple interactions increases activity |
ISO |
xanthohumol results in increased cleavage of and results in increased activity of CASP8 protein xanthohumol results in increased activity of CASP8 protein |
CTD |
PMID:15995977 PMID:26297991 |
|
NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
|
|
G |
Casp9 |
caspase 9 |
multiple interactions increases activity |
ISO |
xanthohumol results in increased cleavage of and results in increased activity of CASP9 protein xanthohumol results in increased activity of CASP9 protein |
CTD |
PMID:15995977 PMID:26297991 |
|
NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
|
|
G |
Cbr1 |
carbonyl reductase 1 |
multiple interactions |
ISO |
xanthohumol inhibits the reaction [CBR1 protein results in increased metabolism of Daunorubicin]; xanthohumol inhibits the reaction [CBR1 protein results in increased reduction of 2,3-hexanedione] |
CTD |
PMID:30849340 |
|
NCBI chr11:33,813,041...33,815,418
Ensembl chr11:33,845,463...33,847,793
|
|
G |
Ccnd1 |
cyclin D1 |
decreases expression multiple interactions |
ISO EXP |
xanthohumol results in decreased expression of CCND1 xanthohumol inhibits the reaction [Azoxymethane results in increased expression of CCND1 protein] |
CTD |
PMID:26297991 PMID:27317025 PMID:31714664 |
|
NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
|
|
G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
xanthohumol results in increased expression of CDKN1A |
CTD |
PMID:26297991 PMID:27317025 |
|
NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
|
|
G |
Cftr |
CF transmembrane conductance regulator |
multiple interactions |
ISO |
xanthohumol inhibits the reaction [CFTR protein results in increased export of Hyaluronic Acid] |
CTD |
PMID:23978416 |
|
NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
|
|
G |
Clcn7 |
chloride voltage-gated channel 7 |
multiple interactions |
ISO |
xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of CLCN7 mRNA] |
CTD |
PMID:23994090 |
|
NCBI chr10:14,492,844...14,518,167
Ensembl chr10:14,492,844...14,516,894
|
|
G |
Creb1 |
cAMP responsive element binding protein 1 |
multiple interactions |
ISO |
xanthohumol results in decreased activity of and results in decreased phosphorylation of CREB1 protein |
CTD |
PMID:27317025 |
|
NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
|
|
G |
Cryz |
crystallin zeta |
increases activity |
ISO |
xanthohumol results in increased activity of CRYZ protein |
CTD |
PMID:17590382 |
|
NCBI chr 2:260,884,315...260,911,827
Ensembl chr 2:260,884,337...260,911,792
|
|
G |
Ctnnb1 |
catenin beta 1 |
multiple interactions |
EXP |
xanthohumol inhibits the reaction [Azoxymethane results in decreased phosphorylation of and results in increased activity of CTNNB1 protein] |
CTD |
PMID:31714664 |
|
NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
|
|
G |
Ctsk |
cathepsin K |
multiple interactions |
ISO |
xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA] |
CTD |
PMID:23994090 |
|
NCBI chr 2:196,655,469...196,666,447
Ensembl chr 2:196,655,469...196,666,446
|
|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions decreases activity increases expression |
ISO |
xanthohumol promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A1 mRNA] xanthohumol results in decreased activity of CYP1A1 protein xanthohumol results in increased expression of CYP1A1 mRNA |
CTD |
PMID:22138251 PMID:23503627 |
|
NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
|
|
G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases expression multiple interactions |
ISO |
xanthohumol results in increased expression of CYP1A2 mRNA xanthohumol inhibits the reaction [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A2 mRNA] |
CTD |
PMID:22138251 |
|
NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
|
|
G |
Dio2 |
iodothyronine deiodinase 2 |
decreases activity |
ISO |
xanthohumol results in decreased activity of DIO2 protein |
CTD |
PMID:30561685 |
|
NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723
|
|
G |
Dio3 |
iodothyronine deiodinase 3 |
decreases activity |
ISO |
xanthohumol results in decreased activity of DIO3 protein |
CTD |
PMID:30561685 |
|
NCBI chr 6:134,627,278...134,629,139
Ensembl chr 6:134,627,278...134,629,138
|
|
G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA] |
CTD |
PMID:23994090 |
|
NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
|
|
G |
Gab2 |
GRB2-associated binding protein 2 |
multiple interactions |
ISO |
xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of GAB2 mRNA] |
CTD |
PMID:23994090 |
|
NCBI chr 1:162,082,876...162,283,379
Ensembl chr 1:162,083,030...162,279,727
|
|
G |
Gsta1 |
glutathione S-transferase alpha 1 |
decreases expression multiple interactions |
ISO |
xanthohumol results in decreased expression of GSTA1 mRNA [xanthohumol co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] results in increased expression of GSTA1 mRNA |
CTD |
PMID:22138251 |
|
NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
|
|
G |
Gstp1 |
glutathione S-transferase pi 1 |
increases expression multiple interactions |
ISO |
xanthohumol results in increased expression of GSTP1 mRNA; xanthohumol results in increased expression of GSTP1 protein [indole-3-carbinol co-treated with xanthohumol] results in increased expression of GSTP1 mRNA; [phenethyl isothiocyanate co-treated with xanthohumol] results in increased expression of GSTP1 mRNA; [phenethyl isothiocyanate co-treated with xanthohumol] results in increased expression of GSTP1 protein; [Resveratrol co-treated with xanthohumol] results in increased expression of GSTP1 mRNA |
CTD |
PMID:23085367 PMID:32070777 |
|
NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
|
|
G |
Gstt1 |
glutathione S-transferase theta 1 |
increases expression |
ISO |
xanthohumol results in increased expression of GSTT1 mRNA; xanthohumol results in increased expression of GSTT1 protein |
CTD |
PMID:23085367 |
|
NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
|
|
G |
Hmox1 |
heme oxygenase 1 |
increases expression |
ISO |
xanthohumol results in increased expression of HMOX1 mRNA; xanthohumol results in increased expression of HMOX1 protein |
CTD |
PMID:23085367 |
|
NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
|
|
G |
Icam1 |
intercellular adhesion molecule 1 |
decreases expression |
ISO |
xanthohumol results in decreased expression of ICAM1 protein |
CTD |
PMID:23503627 |
|
NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions increases expression |
ISO |
Acetylcysteine inhibits the reaction [xanthohumol results in increased expression of IL1B protein] |
CTD |
PMID:31629901 |
|
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
|
|
G |
Il6 |
interleukin 6 |
decreases expression |
ISO |
xanthohumol results in decreased expression of IL6 mRNA |
CTD |
PMID:16019205 |
|
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
|
|
G |
Mapk1 |
mitogen activated protein kinase 1 |
decreases phosphorylation decreases activity |
ISO |
xanthohumol results in decreased phosphorylation of MAPK1 protein xanthohumol results in decreased activity of MAPK1 protein |
CTD |
PMID:26297991 PMID:27317025 |
|
NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions decreases activity decreases phosphorylation |
ISO |
xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of MAPK3 mRNA] xanthohumol results in decreased activity of MAPK3 protein xanthohumol results in decreased phosphorylation of MAPK3 protein |
CTD |
PMID:23994090 PMID:26297991 PMID:27317025 |
|
NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
|
|
G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions decreases expression |
ISO |
xanthohumol results in decreased expression of and results in decreased activity of MMP9 protein xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 mRNA] xanthohumol results in decreased expression of MMP9 mRNA |
CTD |
PMID:23562496 PMID:23994090 |
|
NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
|
|
G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
multiple interactions |
EXP |
xanthohumol inhibits the reaction [Azoxymethane results in increased expression of MYC protein] |
CTD |
PMID:31714664 |
|
NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
|
|
G |
Myl2 |
myosin light chain 2 |
multiple interactions |
ISO |
xanthohumol results in decreased phosphorylation of and results in decreased activity of MYL2 protein |
CTD |
PMID:23503627 |
|
NCBI chr12:39,951,863...39,959,065
Ensembl chr12:39,951,987...39,958,239
|
|
G |
Nat2 |
N-acetyltransferase 2 |
multiple interactions |
ISO |
[xanthohumol co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of NAT2 mRNA |
CTD |
PMID:22138251 |
|
NCBI chr16:23,960,709...23,991,570
Ensembl chr16:23,961,067...23,991,570
|
|
G |
Nfatc1 |
nuclear factor of activated T-cells 1 |
multiple interactions |
ISO |
xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA] |
CTD |
PMID:23994090 |
|
NCBI chr18:77,203,517...77,322,690
Ensembl chr18:77,203,525...77,322,690
|
|
G |
Nfe2l2 |
nuclear factor, erythroid 2-like 2 |
affects localization multiple interactions increases expression increases activity |
ISO |
xanthohumol affects the localization of NFE2L2 protein [xanthohumol co-treated with phenethyl isothiocyanate] results in increased activity of NFE2L2 protein; [xanthohumol co-treated with phenethyl isothiocyanate] results in increased expression of and results in increased activity of NFE2L2 protein; [xanthohumol co-treated with phenethyl isothiocyanate] results in increased expression of NFE2L2 mRNA; [xanthohumol co-treated with Resveratrol] results in increased expression of NFE2L2 mRNA; [xanthohumol co-treated with Resveratrol] results in increased expression of NFE2L2 protein xanthohumol results in increased expression of NFE2L2 mRNA; xanthohumol results in increased expression of NFE2L2 protein xanthohumol results in increased activity of NFE2L2 protein |
CTD |
PMID:23085367 PMID:32070777 |
|
NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
|
|
G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions decreases activity decreases expression |
ISO |
[xanthohumol co-treated with phenethyl isothiocyanate] results in decreased expression of and results in decreased activity of NFKB1 protein; [xanthohumol co-treated with phenethyl isothiocyanate] results in decreased expression of NFKB1 mRNA; [xanthohumol co-treated with Resveratrol] results in decreased expression of NFKB1 mRNA xanthohumol results in decreased activity of NFKB1 protein xanthohumol results in decreased expression of NFKB1 mRNA |
CTD |
PMID:32070777 |
|
NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
|
|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
EXP |
xanthohumol inhibits the reaction [Azoxymethane results in increased expression of NOS2 mRNA] |
CTD |
PMID:31714664 |
|
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
|
|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression multiple interactions |
ISO |
xanthohumol results in increased expression of NQO1 protein [indole-3-carbinol co-treated with xanthohumol] results in increased expression of NQO1 mRNA; [phenethyl isothiocyanate co-treated with xanthohumol] results in increased expression of NQO1 mRNA; [Resveratrol co-treated with xanthohumol] results in increased expression of NQO1 mRNA; [xanthohumol co-treated with phenethyl isothiocyanate] results in increased expression of NQO1 protein xanthohumol results in increased expression of NQO1 mRNA; xanthohumol results in increased expression of NQO1 protein |
CTD |
PMID:23085367 PMID:26473469 PMID:32070777 |
|
NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
|
|
G |
Ostm1 |
osteoclastogenesis associated transmembrane protein 1 |
multiple interactions |
ISO |
xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of OSTM1 mRNA] |
CTD |
PMID:23994090 |
|
NCBI chr20:47,394,979...47,430,304
Ensembl chr20:47,395,014...47,430,284
|
|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage |
ISO |
xanthohumol results in increased cleavage of PARP1 protein |
CTD |
PMID:15995977 |
|
NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
|
|
G |
Pik3cg |
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma |
multiple interactions |
ISO |
xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of PIK3CG mRNA] |
CTD |
PMID:23994090 |
|
NCBI chr 6:51,465,696...51,501,234
Ensembl chr 6:51,465,908...51,498,337
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
decreases activity multiple interactions decreases expression |
ISO EXP |
xanthohumol results in decreased activity of PTGS2 protein [xanthohumol co-treated with indole-3-carbinol] results in decreased expression of PTGS2 mRNA; [xanthohumol co-treated with phenethyl isothiocyanate] results in decreased expression of PTGS2 mRNA; [xanthohumol co-treated with phenethyl isothiocyanate] results in decreased expression of PTGS2 protein; [xanthohumol co-treated with Resveratrol] results in decreased expression of PTGS2 mRNA xanthohumol results in decreased expression of PTGS2 mRNA xanthohumol inhibits the reaction [Azoxymethane results in increased expression of PTGS2 mRNA] |
CTD |
PMID:17590382 PMID:31714664 PMID:32070777 |
|
NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
|
|
G |
Pxn |
paxillin |
decreases expression |
ISO |
xanthohumol results in decreased expression of PXN protein |
CTD |
PMID:23503627 |
|
NCBI chr12:46,797,953...46,845,107
Ensembl chr12:46,797,954...46,845,080
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions decreases activity decreases expression |
ISO |
[indole-3-carbinol co-treated with xanthohumol] results in decreased activity of RELA protein; [indole-3-carbinol co-treated with xanthohumol] results in decreased expression of RELA mRNA; [phenethyl isothiocyanate co-treated with xanthohumol] results in decreased expression of and results in decreased activity of RELA protein; [phenethyl isothiocyanate co-treated with xanthohumol] results in decreased expression of RELA mRNA; [Resveratrol co-treated with xanthohumol] results in decreased activity of RELA protein; [Resveratrol co-treated with xanthohumol] results in decreased expression of RELA mRNA xanthohumol results in decreased activity of RELA protein xanthohumol results in decreased expression of RELA mRNA |
CTD |
PMID:32070777 |
|
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
|
|
G |
S100a4 |
S100 calcium-binding protein A4 |
decreases expression |
ISO |
xanthohumol results in decreased expression of S100A4 protein |
CTD |
PMID:23503627 |
|
NCBI chr 2:189,997,278...189,999,587
Ensembl chr 2:189,997,129...189,999,604
|
|
G |
Sele |
selectin E |
multiple interactions |
ISO |
xanthohumol inhibits the reaction [TNF protein results in increased expression of SELE protein] |
CTD |
PMID:23503627 |
|
NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
|
|
G |
Src |
SRC proto-oncogene, non-receptor tyrosine kinase |
multiple interactions |
ISO |
xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of SRC mRNA] |
CTD |
PMID:23994090 |
|
NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
|
|
G |
Sult1a1 |
sulfotransferase family 1A member 1 |
increases expression decreases expression |
ISO |
xanthohumol results in increased expression of SULT1A1 mRNA xanthohumol results in decreased expression of SULT1A1 mRNA |
CTD |
PMID:22138251 |
|
NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
|
|
G |
Tcirg1 |
T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 |
multiple interactions |
ISO |
xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of TCIRG1 mRNA] |
CTD |
PMID:23994090 |
|
NCBI chr 1:219,126,687...219,139,466
Ensembl chr 1:219,127,602...219,139,464
|
|
G |
Tff1 |
trefoil factor 1 |
increases expression |
ISO |
xanthohumol results in increased expression of TFF1 mRNA |
CTD |
PMID:16019205 |
|
NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
xanthohumol inhibits the reaction [TNF protein results in increased expression of SELE protein] |
CTD |
PMID:23503627 |
|
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
|
|
G |
Tnfsf11 |
TNF superfamily member 11 |
multiple interactions decreases response to substance |
ISO |
xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of AKT2 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of CAR2 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of CLCN7 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of GAB2 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of MAPK3 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of OSTM1 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of PIK3CG mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of SRC mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of TCIRG1 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of TRAF6 mRNA] xanthohumol results in decreased susceptibility to TNFSF11 protein |
CTD |
PMID:23994090 |
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NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
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G |
Tp53 |
tumor protein p53 |
increases expression |
ISO |
xanthohumol results in increased expression of TP53; xanthohumol results in increased expression of TP53 mRNA; xanthohumol results in increased expression of TP53 protein |
CTD |
PMID:23085367 PMID:26297991 PMID:27317025 |
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NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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G |
Traf6 |
TNF receptor associated factor 6 |
multiple interactions |
ISO |
xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of TRAF6 mRNA] |
CTD |
PMID:23994090 |
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NCBI chr 3:91,252,829...91,271,607
Ensembl chr 3:91,252,829...91,271,607
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G |
Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
multiple interactions increases expression |
ISO |
xanthohumol promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of UGT1A1 mRNA] xanthohumol results in increased expression of UGT1A1 mRNA |
CTD |
PMID:22138251 |
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NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
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G |
Ugt1a2 |
UDP glucuronosyltransferase 1 family, polypeptide A2 |
multiple interactions |
ISO |
[xanthohumol co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of UGT1A2 mRNA |
CTD |
PMID:22138251 |
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NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
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G |
Vwf |
von Willebrand factor |
increases expression |
ISO |
xanthohumol results in increased expression of VWF mRNA |
CTD |
PMID:16019205 |
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NCBI chr 4:158,085,059...158,219,525
Ensembl chr 4:158,088,505...158,219,523
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