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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:xanthohumol
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Accession:CHEBI:66331 term browser browse the term
Definition:A member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 4, 2' and 4', a methoxy group at position 6' and a prenyl group at position 3'. Isolated from Humulus lupulus, it induces apoptosis in human malignant glioblastoma cells.
Synonyms:exact_synonym: (2E)-1-[2,4-dihydroxy-6-methoxy-3-(3-methylbut-2-en-1-yl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one
 related_synonym: 2',4,4'-trihydroxy-6'-methoxy-3'-prenylchalcone;   Formula=C21H22O5;   InChI=1S/C21H22O5/c1-13(2)4-10-16-18(24)12-19(26-3)20(21(16)25)17(23)11-7-14-5-8-15(22)9-6-14/h4-9,11-12,22,24-25H,10H2,1-3H3/b11-7+;   InChIKey=ORXQGKIUCDPEAJ-YRNVUSSQSA-N;   SMILES=COc1cc(O)c(CC=C(C)C)c(O)c1C(=O)\\C=C\\c1ccc(O)cc1
 xref: CAS:6754-58-1;   HMDB:HMDB0037479;   KEGG:C16417;   KNApSAcK:C00007099;   LIPID_MAPS_instance:LMPK12120294
 xref_mesh: MESH:C104536
 xref: MetaCyc:CPD-7119;   PMID:14670594;   PMID:15550272;   PMID:15679315;   PMID:15723722;   PMID:19634869;   PMID:22111577;   Patent:EP2579862;   Patent:WO2009126320;   Reaxys:2226282;   Wikipedia:Xanthohumol
 cyclic_relationship: is_conjugate_acid_of CHEBI:134289

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xanthohumol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc5 ATP binding cassette subfamily C member 5 multiple interactions ISO [xanthohumol binds to and results in decreased activity of ABCC5 protein] which results in decreased export of Hyaluronic Acid; xanthohumol binds to and results in decreased activity of ABCC5 protein; xanthohumol inhibits the reaction [ABCC5 protein results in increased export of Hyaluronic Acid] CTD PMID:23978416 NCBI chr11:84,395,982...84,490,215
Ensembl chr11:84,396,033...84,490,211 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of AKT2 mRNA] CTD PMID:23994090 NCBI chr 1:84,400,939...84,451,223
Ensembl chr 1:84,411,726...84,450,162 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated increases activity
increases expression		 ISO xanthohumol results in increased activity of ALPL protein
xanthohumol results in increased expression of ALPL mRNA		 CTD PMID:16019205 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP xanthohumol inhibits the reaction [Azoxymethane results in decreased expression of BAX protein] CTD PMID:31714664 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO
EXP		 xanthohumol results in decreased expression of BCL2; xanthohumol results in decreased expression of BCL2 protein
xanthohumol inhibits the reaction [Azoxymethane results in increased expression of BCL2 protein]		 CTD PMID:15995977 PMID:23562496 PMID:26297991 PMID:31714664 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of CAR2 mRNA] CTD PMID:23994090 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029 		JBrowse link
G Casp3 caspase 3 multiple interactions
decreases activity
increases activity		 ISO
EXP		 xanthohumol results in increased cleavage of and results in increased activity of CASP3 protein
xanthohumol inhibits the reaction [Azoxymethane results in decreased expression of CASP3 protein]
xanthohumol results in decreased activity of CASP3 protein
xanthohumol results in increased activity of CASP3 protein		 CTD PMID:15995977 PMID:26297991 PMID:27317025 PMID:30240731 PMID:31714664 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity		 ISO xanthohumol results in increased cleavage of and results in increased activity of CASP7 protein
xanthohumol results in increased activity of CASP7 protein		 CTD PMID:15995977 PMID:30240731 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity		 ISO xanthohumol results in increased cleavage of and results in increased activity of CASP8 protein
xanthohumol results in increased activity of CASP8 protein		 CTD PMID:15995977 PMID:26297991 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity		 ISO xanthohumol results in increased cleavage of and results in increased activity of CASP9 protein
xanthohumol results in increased activity of CASP9 protein		 CTD PMID:15995977 PMID:26297991 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Cbr1 carbonyl reductase 1 multiple interactions ISO xanthohumol inhibits the reaction [CBR1 protein results in increased metabolism of Daunorubicin]; xanthohumol inhibits the reaction [CBR1 protein results in increased reduction of 2,3-hexanedione] CTD PMID:30849340 NCBI chr11:33,813,041...33,815,418
Ensembl chr11:33,845,463...33,847,793 		JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions		 ISO
EXP		 xanthohumol results in decreased expression of CCND1
xanthohumol inhibits the reaction [Azoxymethane results in increased expression of CCND1 protein]		 CTD PMID:26297991 PMID:27317025 PMID:31714664 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO xanthohumol results in increased expression of CDKN1A CTD PMID:26297991 PMID:27317025 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions ISO xanthohumol inhibits the reaction [CFTR protein results in increased export of Hyaluronic Acid] CTD PMID:23978416 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676 		JBrowse link
G Clcn7 chloride voltage-gated channel 7 multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of CLCN7 mRNA] CTD PMID:23994090 NCBI chr10:14,492,844...14,518,167
Ensembl chr10:14,492,844...14,516,894 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO xanthohumol results in decreased activity of and results in decreased phosphorylation of CREB1 protein CTD PMID:27317025 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435 		JBrowse link
G Cryz crystallin zeta increases activity ISO xanthohumol results in increased activity of CRYZ protein CTD PMID:17590382 NCBI chr 2:260,884,315...260,911,827
Ensembl chr 2:260,884,337...260,911,792 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP xanthohumol inhibits the reaction [Azoxymethane results in decreased phosphorylation of and results in increased activity of CTNNB1 protein] CTD PMID:31714664 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372 		JBrowse link
G Ctsk cathepsin K multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA] CTD PMID:23994090 NCBI chr 2:196,655,469...196,666,447
Ensembl chr 2:196,655,469...196,666,446 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
increases expression		 ISO xanthohumol promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A1 mRNA]
xanthohumol results in decreased activity of CYP1A1 protein
xanthohumol results in increased expression of CYP1A1 mRNA		 CTD PMID:22138251 PMID:23503627 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
multiple interactions		 ISO xanthohumol results in increased expression of CYP1A2 mRNA
xanthohumol inhibits the reaction [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A2 mRNA]		 CTD PMID:22138251 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Dio2 iodothyronine deiodinase 2 decreases activity ISO xanthohumol results in decreased activity of DIO2 protein CTD PMID:30561685 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723 		JBrowse link
G Dio3 iodothyronine deiodinase 3 decreases activity ISO xanthohumol results in decreased activity of DIO3 protein CTD PMID:30561685 NCBI chr 6:134,627,278...134,629,139
Ensembl chr 6:134,627,278...134,629,138 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA] CTD PMID:23994090 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Gab2 GRB2-associated binding protein 2 multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of GAB2 mRNA] CTD PMID:23994090 NCBI chr 1:162,082,876...162,283,379
Ensembl chr 1:162,083,030...162,279,727 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases expression
multiple interactions		 ISO xanthohumol results in decreased expression of GSTA1 mRNA
[xanthohumol co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] results in increased expression of GSTA1 mRNA		 CTD PMID:22138251 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression
multiple interactions		 ISO xanthohumol results in increased expression of GSTP1 mRNA; xanthohumol results in increased expression of GSTP1 protein
[indole-3-carbinol co-treated with xanthohumol] results in increased expression of GSTP1 mRNA; [phenethyl isothiocyanate co-treated with xanthohumol] results in increased expression of GSTP1 mRNA; [phenethyl isothiocyanate co-treated with xanthohumol] results in increased expression of GSTP1 protein; [Resveratrol co-treated with xanthohumol] results in increased expression of GSTP1 mRNA		 CTD PMID:23085367 PMID:32070777 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 increases expression ISO xanthohumol results in increased expression of GSTT1 mRNA; xanthohumol results in increased expression of GSTT1 protein CTD PMID:23085367 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO xanthohumol results in increased expression of HMOX1 mRNA; xanthohumol results in increased expression of HMOX1 protein CTD PMID:23085367 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO xanthohumol results in decreased expression of ICAM1 protein CTD PMID:23503627 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [xanthohumol results in increased expression of IL1B protein] CTD PMID:31629901 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 decreases expression ISO xanthohumol results in decreased expression of IL6 mRNA CTD PMID:16019205 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
decreases activity		 ISO xanthohumol results in decreased phosphorylation of MAPK1 protein
xanthohumol results in decreased activity of MAPK1 protein		 CTD PMID:26297991 PMID:27317025 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases activity
decreases phosphorylation		 ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of MAPK3 mRNA]
xanthohumol results in decreased activity of MAPK3 protein
xanthohumol results in decreased phosphorylation of MAPK3 protein		 CTD PMID:23994090 PMID:26297991 PMID:27317025 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression		 ISO xanthohumol results in decreased expression of and results in decreased activity of MMP9 protein
xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 mRNA]
xanthohumol results in decreased expression of MMP9 mRNA		 CTD PMID:23562496 PMID:23994090 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions EXP xanthohumol inhibits the reaction [Azoxymethane results in increased expression of MYC protein] CTD PMID:31714664 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240 		JBrowse link
G Myl2 myosin light chain 2 multiple interactions ISO xanthohumol results in decreased phosphorylation of and results in decreased activity of MYL2 protein CTD PMID:23503627 NCBI chr12:39,951,863...39,959,065
Ensembl chr12:39,951,987...39,958,239 		JBrowse link
G Nat2 N-acetyltransferase 2 multiple interactions ISO [xanthohumol co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of NAT2 mRNA CTD PMID:22138251 NCBI chr16:23,960,709...23,991,570
Ensembl chr16:23,961,067...23,991,570 		JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA] CTD PMID:23994090 NCBI chr18:77,203,517...77,322,690
Ensembl chr18:77,203,525...77,322,690 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects localization
multiple interactions
increases expression
increases activity		 ISO xanthohumol affects the localization of NFE2L2 protein
[xanthohumol co-treated with phenethyl isothiocyanate] results in increased activity of NFE2L2 protein; [xanthohumol co-treated with phenethyl isothiocyanate] results in increased expression of and results in increased activity of NFE2L2 protein; [xanthohumol co-treated with phenethyl isothiocyanate] results in increased expression of NFE2L2 mRNA; [xanthohumol co-treated with Resveratrol] results in increased expression of NFE2L2 mRNA; [xanthohumol co-treated with Resveratrol] results in increased expression of NFE2L2 protein
xanthohumol results in increased expression of NFE2L2 mRNA; xanthohumol results in increased expression of NFE2L2 protein
xanthohumol results in increased activity of NFE2L2 protein		 CTD PMID:23085367 PMID:32070777 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
decreases activity
decreases expression		 ISO [xanthohumol co-treated with phenethyl isothiocyanate] results in decreased expression of and results in decreased activity of NFKB1 protein; [xanthohumol co-treated with phenethyl isothiocyanate] results in decreased expression of NFKB1 mRNA; [xanthohumol co-treated with Resveratrol] results in decreased expression of NFKB1 mRNA
xanthohumol results in decreased activity of NFKB1 protein
xanthohumol results in decreased expression of NFKB1 mRNA		 CTD PMID:32070777 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP xanthohumol inhibits the reaction [Azoxymethane results in increased expression of NOS2 mRNA] CTD PMID:31714664 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions		 ISO xanthohumol results in increased expression of NQO1 protein
[indole-3-carbinol co-treated with xanthohumol] results in increased expression of NQO1 mRNA; [phenethyl isothiocyanate co-treated with xanthohumol] results in increased expression of NQO1 mRNA; [Resveratrol co-treated with xanthohumol] results in increased expression of NQO1 mRNA; [xanthohumol co-treated with phenethyl isothiocyanate] results in increased expression of NQO1 protein
xanthohumol results in increased expression of NQO1 mRNA; xanthohumol results in increased expression of NQO1 protein		 CTD PMID:23085367 PMID:26473469 PMID:32070777 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
G Ostm1 osteoclastogenesis associated transmembrane protein 1 multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of OSTM1 mRNA] CTD PMID:23994090 NCBI chr20:47,394,979...47,430,304
Ensembl chr20:47,395,014...47,430,284 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO xanthohumol results in increased cleavage of PARP1 protein CTD PMID:15995977 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of PIK3CG mRNA] CTD PMID:23994090 NCBI chr 6:51,465,696...51,501,234
Ensembl chr 6:51,465,908...51,498,337 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases activity
multiple interactions
decreases expression		 ISO
EXP		 xanthohumol results in decreased activity of PTGS2 protein
[xanthohumol co-treated with indole-3-carbinol] results in decreased expression of PTGS2 mRNA; [xanthohumol co-treated with phenethyl isothiocyanate] results in decreased expression of PTGS2 mRNA; [xanthohumol co-treated with phenethyl isothiocyanate] results in decreased expression of PTGS2 protein; [xanthohumol co-treated with Resveratrol] results in decreased expression of PTGS2 mRNA
xanthohumol results in decreased expression of PTGS2 mRNA
xanthohumol inhibits the reaction [Azoxymethane results in increased expression of PTGS2 mRNA]		 CTD PMID:17590382 PMID:31714664 PMID:32070777 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Pxn paxillin decreases expression ISO xanthohumol results in decreased expression of PXN protein CTD PMID:23503627 NCBI chr12:46,797,953...46,845,107
Ensembl chr12:46,797,954...46,845,080 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases activity
decreases expression		 ISO [indole-3-carbinol co-treated with xanthohumol] results in decreased activity of RELA protein; [indole-3-carbinol co-treated with xanthohumol] results in decreased expression of RELA mRNA; [phenethyl isothiocyanate co-treated with xanthohumol] results in decreased expression of and results in decreased activity of RELA protein; [phenethyl isothiocyanate co-treated with xanthohumol] results in decreased expression of RELA mRNA; [Resveratrol co-treated with xanthohumol] results in decreased activity of RELA protein; [Resveratrol co-treated with xanthohumol] results in decreased expression of RELA mRNA
xanthohumol results in decreased activity of RELA protein
xanthohumol results in decreased expression of RELA mRNA		 CTD PMID:32070777 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G S100a4 S100 calcium-binding protein A4 decreases expression ISO xanthohumol results in decreased expression of S100A4 protein CTD PMID:23503627 NCBI chr 2:189,997,278...189,999,587
Ensembl chr 2:189,997,129...189,999,604 		JBrowse link
G Sele selectin E multiple interactions ISO xanthohumol inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:23503627 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of SRC mRNA] CTD PMID:23994090 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases expression
decreases expression		 ISO xanthohumol results in increased expression of SULT1A1 mRNA
xanthohumol results in decreased expression of SULT1A1 mRNA		 CTD PMID:22138251 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109 		JBrowse link
G Tcirg1 T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of TCIRG1 mRNA] CTD PMID:23994090 NCBI chr 1:219,126,687...219,139,466
Ensembl chr 1:219,127,602...219,139,464 		JBrowse link
G Tff1 trefoil factor 1 increases expression ISO xanthohumol results in increased expression of TFF1 mRNA CTD PMID:16019205 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO xanthohumol inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:23503627 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions
decreases response to substance		 ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of AKT2 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of CAR2 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of CLCN7 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of GAB2 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of MAPK3 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of OSTM1 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of PIK3CG mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of SRC mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of TCIRG1 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of TRAF6 mRNA]
xanthohumol results in decreased susceptibility to TNFSF11 protein		 CTD PMID:23994090 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO xanthohumol results in increased expression of TP53; xanthohumol results in increased expression of TP53 mRNA; xanthohumol results in increased expression of TP53 protein CTD PMID:23085367 PMID:26297991 PMID:27317025 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of TRAF6 mRNA] CTD PMID:23994090 NCBI chr 3:91,252,829...91,271,607
Ensembl chr 3:91,252,829...91,271,607 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions
increases expression		 ISO xanthohumol promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of UGT1A1 mRNA]
xanthohumol results in increased expression of UGT1A1 mRNA		 CTD PMID:22138251 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 multiple interactions ISO [xanthohumol co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of UGT1A2 mRNA CTD PMID:22138251 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Vwf von Willebrand factor increases expression ISO xanthohumol results in increased expression of VWF mRNA CTD PMID:16019205 NCBI chr 4:158,085,059...158,219,525
Ensembl chr 4:158,088,505...158,219,523 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19883
    role 19833
      biological role 19833
        antimicrobial agent 17416
          antiviral agent 10277
            xanthohumol 62
Path 2
Term Annotations click to browse term
  CHEBI ontology 19883
    subatomic particle 19881
      composite particle 19881
        hadron 19881
          baryon 19881
            nucleon 19881
              atomic nucleus 19881
                atom 19881
                  main group element atom 19771
                    p-block element atom 19771
                      carbon group element atom 19679
                        carbon atom 19668
                          organic molecular entity 19668
                            organic group 18580
                              organic divalent group 18571
                                organodiyl group 18571
                                  carbonyl group 18479
                                    carbonyl compound 18479
                                      ketone 16222
                                        alpha,beta-unsaturated ketone 8546
                                          enone 8546
                                            chalcones 149
                                              xanthohumol 62
paths to the root