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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:xanthohumol
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Accession:CHEBI:66331 term browser browse the term
Definition:A member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 4, 2' and 4', a methoxy group at position 6' and a prenyl group at position 3'. Isolated from Humulus lupulus, it induces apoptosis in human malignant glioblastoma cells.
Synonyms:exact_synonym: (2E)-1-[2,4-dihydroxy-6-methoxy-3-(3-methylbut-2-en-1-yl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one
 related_synonym: 2',4,4'-trihydroxy-6'-methoxy-3'-prenylchalcone;   Formula=C21H22O5;   InChI=1S/C21H22O5/c1-13(2)4-10-16-18(24)12-19(26-3)20(21(16)25)17(23)11-7-14-5-8-15(22)9-6-14/h4-9,11-12,22,24-25H,10H2,1-3H3/b11-7+;   InChIKey=ORXQGKIUCDPEAJ-YRNVUSSQSA-N;   SMILES=COc1cc(O)c(CC=C(C)C)c(O)c1C(=O)\\C=C\\c1ccc(O)cc1
 xref: CAS:6754-58-1;   HMDB:HMDB0037479;   KEGG:C16417;   KNApSAcK:C00007099;   LIPID_MAPS_instance:LMPK12120294
 xref_mesh: MESH:C104536
 xref: MetaCyc:CPD-7119;   PMID:14670594;   PMID:15550272;   PMID:15679315;   PMID:15723722;   PMID:19634869;   PMID:22111577;   Patent:EP2579862;   Patent:WO2009126320;   Reaxys:2226282;   Wikipedia:Xanthohumol
 cyclic_relationship: is_conjugate_acid_of CHEBI:134289



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xanthohumol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc5 ATP binding cassette subfamily C member 5 multiple interactions ISO [xanthohumol binds to and results in decreased activity of ABCC5 protein] which results in decreased export of Hyaluronic Acid; xanthohumol binds to and results in decreased activity of ABCC5 protein; xanthohumol inhibits the reaction [ABCC5 protein results in increased export of Hyaluronic Acid] CTD PMID:23978416 NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
ISO xanthohumol results in decreased phosphorylation of AKT1 protein
AKT1 protein modified form inhibits the reaction [xanthohumol results in increased expression of BBC3 protein]
CTD PMID:35259468 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Akt2 AKT serine/threonine kinase 2 multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of AKT2 mRNA] CTD PMID:23994090 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated increases activity
increases expression
ISO xanthohumol results in increased activity of ALPL protein
xanthohumol results in increased expression of ALPL mRNA
CTD PMID:16019205 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP xanthohumol inhibits the reaction [Azoxymethane results in decreased expression of BAX protein] CTD PMID:31714664 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression
multiple interactions
ISO xanthohumol results in increased expression of BBC3 mRNA; xanthohumol results in increased expression of BBC3 protein
AKT1 protein modified form inhibits the reaction [xanthohumol results in increased expression of BBC3 protein]; BBC3 protein affects the reaction [xanthohumol results in increased cleavage of CASP3 protein]; BBC3 protein affects the reaction [xanthohumol results in increased cleavage of CASP9 protein]; FOXO3 protein affects the reaction [xanthohumol results in increased expression of BBC3 protein]; xanthohumol promotes the reaction [Cisplatin results in increased expression of BBC3 protein]; xanthohumol promotes the reaction [Pemetrexed results in increased expression of BBC3 protein]
CTD PMID:35259468 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO
EXP
xanthohumol results in decreased expression of BCL2; xanthohumol results in decreased expression of BCL2 protein
xanthohumol inhibits the reaction [Azoxymethane results in increased expression of BCL2 protein]
CTD PMID:15995977 PMID:23562496 PMID:26297991 PMID:31714664 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of CAR2 mRNA] CTD PMID:23994090 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
decreases activity
increases activity
ISO
EXP
BBC3 protein affects the reaction [xanthohumol results in increased cleavage of CASP3 protein]; FOXO3 protein affects the reaction [xanthohumol results in increased cleavage of CASP3 protein]; xanthohumol results in increased cleavage of and results in increased activity of CASP3 protein
xanthohumol inhibits the reaction [Azoxymethane results in decreased expression of CASP3 protein]
xanthohumol results in decreased activity of CASP3 protein
xanthohumol results in increased activity of CASP3 protein
CTD PMID:15995977 PMID:26297991 PMID:27317025 PMID:30240731 PMID:31714664 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity
ISO xanthohumol results in increased cleavage of and results in increased activity of CASP7 protein
xanthohumol results in increased activity of CASP7 protein
CTD PMID:15995977 PMID:30240731 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity
ISO xanthohumol results in increased cleavage of and results in increased activity of CASP8 protein
xanthohumol results in increased activity of CASP8 protein
CTD PMID:15995977 PMID:26297991 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage
increases activity
ISO BBC3 protein affects the reaction [xanthohumol results in increased cleavage of CASP9 protein]; xanthohumol results in increased cleavage of and results in increased activity of CASP9 protein
xanthohumol results in increased activity of CASP9 protein
CTD PMID:15995977 PMID:26297991 PMID:35259468 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions
ISO
EXP
xanthohumol results in decreased expression of CCND1
xanthohumol inhibits the reaction [Azoxymethane results in increased expression of CCND1 protein]
CTD PMID:26297991 PMID:27317025 PMID:31714664 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO xanthohumol results in increased expression of CDKN1A CTD PMID:26297991 PMID:27317025 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions ISO xanthohumol inhibits the reaction [CFTR protein results in increased export of Hyaluronic Acid] CTD PMID:23978416 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G Clcn7 chloride voltage-gated channel 7 multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of CLCN7 mRNA] CTD PMID:23994090 NCBI chr10:14,151,758...14,177,130
Ensembl chr10:14,151,758...14,177,130
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO xanthohumol results in decreased activity of and results in decreased phosphorylation of CREB1 protein CTD PMID:27317025 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Cryz crystallin zeta increases activity ISO xanthohumol results in increased activity of CRYZ protein CTD PMID:17590382 NCBI chr 2:243,552,037...243,580,369
Ensembl chr 2:243,552,119...243,579,758
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP xanthohumol inhibits the reaction [Azoxymethane results in decreased phosphorylation of and results in increased activity of CTNNB1 protein] CTD PMID:31714664 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Ctsk cathepsin K multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA] CTD PMID:23994090 NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
increases expression
ISO xanthohumol promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A1 mRNA]
xanthohumol results in decreased activity of CYP1A1 protein
xanthohumol results in increased expression of CYP1A1 mRNA
CTD PMID:22138251 PMID:23503627 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
multiple interactions
ISO xanthohumol results in increased expression of CYP1A2 mRNA
xanthohumol inhibits the reaction [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A2 mRNA]
CTD PMID:22138251 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Dio2 iodothyronine deiodinase 2 decreases activity ISO xanthohumol results in decreased activity of DIO2 protein CTD PMID:30561685 NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809
JBrowse link
G Dio3 iodothyronine deiodinase 3 decreases activity ISO xanthohumol results in decreased activity of DIO3 protein CTD PMID:30561685 NCBI chr 6:129,285,747...129,287,608
Ensembl chr 6:129,285,749...129,286,660
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
decreases expression
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [xanthohumol results in decreased expression of ESR1 protein]; xanthohumol promotes the reaction [Estradiol results in decreased expression of ESR1 protein] CTD PMID:32986415 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA] CTD PMID:23994090 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Foxo3 forkhead box O3 multiple interactions
decreases phosphorylation
ISO FOXO3 protein affects the reaction [xanthohumol results in increased cleavage of CASP3 protein]; FOXO3 protein affects the reaction [xanthohumol results in increased expression of BBC3 protein]
xanthohumol results in decreased phosphorylation of FOXO3 protein
CTD PMID:35259468 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
JBrowse link
G Gab2 GRB2-associated binding protein 2 multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of GAB2 mRNA] CTD PMID:23994090 NCBI chr 1:151,429,844...151,625,708
Ensembl chr 1:151,429,695...151,625,031
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases expression
multiple interactions
ISO xanthohumol results in decreased expression of GSTA1 mRNA
[xanthohumol co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] results in increased expression of GSTA1 mRNA
CTD PMID:22138251 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression
multiple interactions
ISO xanthohumol results in increased expression of GSTP1 mRNA; xanthohumol results in increased expression of GSTP1 protein
[indole-3-carbinol co-treated with xanthohumol] results in increased expression of GSTP1 mRNA; [phenethyl isothiocyanate co-treated with xanthohumol] results in increased expression of GSTP1 mRNA; [phenethyl isothiocyanate co-treated with xanthohumol] results in increased expression of GSTP1 protein; [Resveratrol co-treated with xanthohumol] results in increased expression of GSTP1 mRNA
CTD PMID:23085367 PMID:32070777 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Gstt1 glutathione S-transferase theta 1 increases expression ISO xanthohumol results in increased expression of GSTT1 mRNA; xanthohumol results in increased expression of GSTT1 protein CTD PMID:23085367 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO xanthohumol results in increased expression of HMOX1 mRNA; xanthohumol results in increased expression of HMOX1 protein CTD PMID:23085367 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO xanthohumol results in decreased expression of ICAM1 protein CTD PMID:23503627 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [xanthohumol results in increased expression of IL1B protein] CTD PMID:31629901 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 decreases expression ISO xanthohumol results in decreased expression of IL6 mRNA CTD PMID:16019205 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G LOC102556347 carbonyl reductase [NADPH] 1-like multiple interactions ISO xanthohumol inhibits the reaction [CBR1 protein results in increased metabolism of Daunorubicin]; xanthohumol inhibits the reaction [CBR1 protein results in increased reduction of 2,3-hexanedione] CTD PMID:30849340 NCBI chr11:32,892,640...32,895,277
Ensembl chr11:32,857,991...32,895,275
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
decreases activity
ISO xanthohumol results in decreased phosphorylation of MAPK1 protein
xanthohumol results in decreased activity of MAPK1 protein
CTD PMID:26297991 PMID:27317025 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases activity
decreases phosphorylation
ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of MAPK3 mRNA]
xanthohumol results in decreased activity of MAPK3 protein
xanthohumol results in decreased phosphorylation of MAPK3 protein
CTD PMID:23994090 PMID:26297991 PMID:27317025 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO xanthohumol results in decreased expression of MKI67 protein CTD PMID:35259468 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
ISO xanthohumol results in decreased expression of and results in decreased activity of MMP9 protein
xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 mRNA]
xanthohumol results in decreased expression of MMP9 mRNA
CTD PMID:23562496 PMID:23994090 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions EXP xanthohumol inhibits the reaction [Azoxymethane results in increased expression of MYC protein] CTD PMID:31714664 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Myl2 myosin light chain 2 multiple interactions ISO xanthohumol results in decreased phosphorylation of and results in decreased activity of MYL2 protein CTD PMID:23503627 NCBI chr12:34,454,223...34,468,554
Ensembl chr12:34,454,218...34,468,983
JBrowse link
G Nat2 N-acetyltransferase 2 multiple interactions ISO [xanthohumol co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of NAT2 mRNA CTD PMID:22138251 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA] CTD PMID:23994090 NCBI chr18:74,046,421...74,156,041
Ensembl chr18:74,046,904...74,156,028
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects localization
multiple interactions
increases expression
increases activity
ISO xanthohumol affects the localization of NFE2L2 protein
[xanthohumol co-treated with phenethyl isothiocyanate] results in increased activity of NFE2L2 protein; [xanthohumol co-treated with phenethyl isothiocyanate] results in increased expression of and results in increased activity of NFE2L2 protein; [xanthohumol co-treated with phenethyl isothiocyanate] results in increased expression of NFE2L2 mRNA; [xanthohumol co-treated with Resveratrol] results in increased expression of NFE2L2 mRNA; [xanthohumol co-treated with Resveratrol] results in increased expression of NFE2L2 protein
xanthohumol results in increased expression of NFE2L2 mRNA; xanthohumol results in increased expression of NFE2L2 protein
xanthohumol results in increased activity of NFE2L2 protein
CTD PMID:23085367 PMID:32070777 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
decreases activity
decreases expression
ISO [xanthohumol co-treated with phenethyl isothiocyanate] results in decreased expression of and results in decreased activity of NFKB1 protein; [xanthohumol co-treated with phenethyl isothiocyanate] results in decreased expression of NFKB1 mRNA; [xanthohumol co-treated with Resveratrol] results in decreased expression of NFKB1 mRNA
xanthohumol results in decreased activity of NFKB1 protein
xanthohumol results in decreased expression of NFKB1 mRNA
CTD PMID:32070777 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP xanthohumol inhibits the reaction [Azoxymethane results in increased expression of NOS2 mRNA] CTD PMID:31714664 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
ISO xanthohumol results in increased expression of NQO1 protein
[indole-3-carbinol co-treated with xanthohumol] results in increased expression of NQO1 mRNA; [phenethyl isothiocyanate co-treated with xanthohumol] results in increased expression of NQO1 mRNA; [Resveratrol co-treated with xanthohumol] results in increased expression of NQO1 mRNA; [xanthohumol co-treated with phenethyl isothiocyanate] results in increased expression of NQO1 protein
xanthohumol results in increased expression of NQO1 mRNA; xanthohumol results in increased expression of NQO1 protein
CTD PMID:23085367 PMID:26473469 PMID:32070777 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Ostm1 osteoclastogenesis associated transmembrane protein 1 multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of OSTM1 mRNA] CTD PMID:23994090 NCBI chr20:46,071,657...46,187,049
Ensembl chr20:46,153,075...46,187,023
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO xanthohumol results in increased cleavage of PARP1 protein CTD PMID:15995977 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of PIK3CG mRNA] CTD PMID:23994090 NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases activity
multiple interactions
decreases expression
ISO
EXP
xanthohumol results in decreased activity of PTGS2 protein
[xanthohumol co-treated with indole-3-carbinol] results in decreased expression of PTGS2 mRNA; [xanthohumol co-treated with phenethyl isothiocyanate] results in decreased expression of PTGS2 mRNA; [xanthohumol co-treated with phenethyl isothiocyanate] results in decreased expression of PTGS2 protein; [xanthohumol co-treated with Resveratrol] results in decreased expression of PTGS2 mRNA
xanthohumol results in decreased expression of PTGS2 mRNA
xanthohumol inhibits the reaction [Azoxymethane results in increased expression of PTGS2 mRNA]
CTD PMID:17590382 PMID:31714664 PMID:32070777 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Pxn paxillin decreases expression ISO xanthohumol results in decreased expression of PXN protein CTD PMID:23503627 NCBI chr12:41,060,791...41,107,962
Ensembl chr12:41,060,791...41,107,931
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases activity
decreases expression
ISO [indole-3-carbinol co-treated with xanthohumol] results in decreased activity of RELA protein; [indole-3-carbinol co-treated with xanthohumol] results in decreased expression of RELA mRNA; [phenethyl isothiocyanate co-treated with xanthohumol] results in decreased expression of and results in decreased activity of RELA protein; [phenethyl isothiocyanate co-treated with xanthohumol] results in decreased expression of RELA mRNA; [Resveratrol co-treated with xanthohumol] results in decreased activity of RELA protein; [Resveratrol co-treated with xanthohumol] results in decreased expression of RELA mRNA
xanthohumol results in decreased activity of RELA protein
xanthohumol results in decreased expression of RELA mRNA
CTD PMID:32070777 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G S100a4 S100 calcium-binding protein A4 decreases expression ISO xanthohumol results in decreased expression of S100A4 protein CTD PMID:23503627 NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254
JBrowse link
G Sele selectin E multiple interactions ISO xanthohumol inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:23503627 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of SRC mRNA] CTD PMID:23994090 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases expression
decreases expression
ISO xanthohumol results in increased expression of SULT1A1 mRNA
xanthohumol results in decreased expression of SULT1A1 mRNA
CTD PMID:22138251 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
G Tcirg1 T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of TCIRG1 mRNA] CTD PMID:23994090 NCBI chr 1:201,127,034...201,138,787
Ensembl chr 1:201,127,034...201,138,742
JBrowse link
G Tff1 trefoil factor 1 increases expression ISO xanthohumol results in increased expression of TFF1 mRNA CTD PMID:16019205 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO xanthohumol inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:23503627 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions
decreases response to substance
ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of AKT2 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of CAR2 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of CLCN7 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of GAB2 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of MAPK3 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of OSTM1 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of PIK3CG mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of SRC mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of TCIRG1 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of TRAF6 mRNA]
xanthohumol results in decreased susceptibility to TNFSF11 protein
CTD PMID:23994090 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
JBrowse link
G Tp53 tumor protein p53 increases expression ISO xanthohumol results in increased expression of TP53; xanthohumol results in increased expression of TP53 mRNA; xanthohumol results in increased expression of TP53 protein CTD PMID:23085367 PMID:26297991 PMID:27317025 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of TRAF6 mRNA] CTD PMID:23994090 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions
increases expression
ISO xanthohumol promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of UGT1A1 mRNA]
xanthohumol results in increased expression of UGT1A1 mRNA
CTD PMID:22138251 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 multiple interactions ISO [xanthohumol co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of UGT1A2 mRNA CTD PMID:22138251 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Vwf von Willebrand factor increases expression ISO xanthohumol results in increased expression of VWF mRNA CTD PMID:16019205 NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      biological role 20011
        antimicrobial agent 17818
          antiviral agent 10485
            xanthohumol 67
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic group 18988
                              organic divalent group 18950
                                organodiyl group 18974
                                  carbonyl group 18903
                                    carbonyl compound 18925
                                      ketone 17115
                                        alpha,beta-unsaturated ketone 9968
                                          enone 9968
                                            chalcones 906
                                              xanthohumol 67
paths to the root