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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:trierixin
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Accession:CHEBI:66262 term browser browse the term
Definition:A 21-membered macrocycle isolated from the fermentation broth of Streptomyces sp.AC654. It exhibits antineoplastic activity.
Synonyms:exact_synonym: (6E,8E,10E,16Z)-15,22,24-trihydroxy-5-methoxy-14,16-dimethyl-23-(methylsulfanyl)-3-oxo-2-azabicyclo[18.3.1]tetracosa-1(24),6,8,10,16,20,22-heptaen-13-yl N-(cyclohexylcarbonyl)alaninate
 related_synonym: Formula=C37H52N2O8S;   InChI=1S/C37H52N2O8S/c1-23-15-14-18-27-21-29(40)35(48-5)32(34(27)43)39-31(41)22-28(46-4)19-12-7-6-8-13-20-30(24(2)33(23)42)47-37(45)25(3)38-36(44)26-16-10-9-11-17-26/h6-8,12-13,15,19,21,24-26,28,30,33,40,42-43H,9-11,14,16-18,20,22H2,1-5H3,(H,38,44)(H,39,41)/b7-6+,13-8+,19-12+,23-15-;   InChIKey=JYAJEGBJMODZBK-GTRHLNJYSA-N;   SMILES=COC1CC(=O)Nc2c(O)c(CC\\C=C(C)/C(O)C(C)C(C\\C=C\\C=C\\C=C\\1)OC(=O)C(C)NC(=O)C1CCCCC1)cc(O)c2SC
 xref_mesh: MESH:C525271
 xref: PMID:17917237;   PMID:17917242;   PMID:21448188


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trierixin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO trierixin inhibits the reaction [TNF protein results in increased expression of and affects the localization of ICAM1 protein] CTD PMID:21448188 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO trierixin inhibits the reaction [TNF protein results in increased expression of and affects the localization of ICAM1 protein] CTD PMID:21448188 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO trierixin inhibits the reaction [Thapsigargin results in increased expression of XBP1 mRNA]; trierixin inhibits the reaction [Thapsigargin results in increased splicing of XBP1 mRNA] CTD PMID:17917237 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        antimicrobial agent 17312
          trierixin 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        carboacyl group 17348
                                          univalent carboacyl group 17348
                                            carbamoyl group 17134
                                              carboxamide 17134
                                                lactam 8027
                                                  trierixin 3
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