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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:MK 571
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Accession:CHEBI:6619 term browser browse the term
Definition:A quinoline that has formula C26H27ClN2O3S2.
Synonyms:related_synonym: Formula=C26H27ClN2O3S2;   InChI=1S/C26H27ClN2O3S2/c1-29(2)24(30)12-14-33-26(34-15-13-25(31)32)20-5-3-4-18(16-20)6-10-22-11-8-19-7-9-21(27)17-23(19)28-22/h3-11,16-17,26H,12-15H2,1-2H3,(H,31,32)/b10-6+;   InChIKey=AXUZQJFHDNNPFG-UXBLZVDNSA-N;   SMILES=CN(C)C(=O)CCSC(SCCC(O)=O)c1cccc(\\C=C\\c2ccc3ccc(Cl)cc3n2)c1;   Verlukast
 xref: CAS:115104-28-4;   KEGG:C11239
 xref_mesh: MESH:C059141



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MK 571 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca8b ATP-binding cassette, sub-family A member 8b multiple interactions ISO verlukast inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide] CTD PMID:12379217 NCBI chr11:109,823,016...109,886,642
Ensembl chr11:109,823,016...109,886,671
JBrowse link
G Abcb11 ATP-binding cassette, sub-family B member 11 decreases activity
multiple interactions
ISO verlukast results in decreased activity of ABCB11 protein
verlukast inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
CTD PMID:20829430 PMID:23956101 PMID:24014644 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958
JBrowse link
G Abcb1a ATP-binding cassette, sub-family B member 1A decreases activity ISO verlukast results in decreased activity of ABCB1 protein CTD PMID:16316932 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
JBrowse link
G Abcc1 ATP-binding cassette, sub-family C member 1 multiple interactions
decreases activity
ISO
EXP
[verlukast affects the activity of ABCC1 protein] which results in increased abundance of fluorexon; [verlukast binds to and results in decreased activity of ABCC1 protein] inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]; [verlukast results in decreased activity of ABCC1 protein] which results in decreased export of calcein AM; [verlukast results in decreased activity of ABCC1 protein] which results in decreased export of Daunorubicin; [verlukast results in decreased activity of ABCC1 protein] which results in increased susceptibility to Arsenic Trioxide; verlukast inhibits the reaction [ABCC1 protein affects the export of fluorexon]; verlukast inhibits the reaction [ABCC1 protein affects the transport of Bilirubin]; verlukast inhibits the reaction [ABCC1 protein affects the transport of S-(2,4-dinitrophenyl)glutathione]; verlukast inhibits the reaction [ABCC1 protein mutant form results in increased transport of estradiol-17 beta-glucuronide]; verlukast inhibits the reaction [ABCC1 protein results in decreased susceptibility to Antimony Potassium Tartrate]; verlukast inhibits the reaction [ABCC1 protein results in decreased susceptibility to Arsenic Trioxide]; verlukast inhibits the reaction [ABCC1 protein results in decreased susceptibility to Doxorubicin]; verlukast inhibits the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; verlukast inhibits the reaction [ABCC1 protein results in decreased susceptibility to Mercuric Chloride]; verlukast inhibits the reaction [ABCC1 protein results in decreased susceptibility to sodium arsenate]; verlukast inhibits the reaction [ABCC1 protein results in decreased susceptibility to Vincristine]; verlukast inhibits the reaction [ABCC1 protein results in decreased uptake of and results in decreased susceptibility to Arsenic Trioxide]; verlukast inhibits the reaction [ABCC1 protein results in increased export of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein]; verlukast inhibits the reaction [ABCC1 protein results in increased export of Daunorubicin]; verlukast inhibits the reaction [ABCC1 protein results in increased export of fluorexon]; verlukast inhibits the reaction [ABCC1 protein results in increased export of Methylmercury Compounds]; verlukast inhibits the reaction [ABCC1 protein results in increased secretion of Antimony Potassium Tartrate]; verlukast inhibits the reaction [ABCC1 protein results in increased transport of calcein AM]; verlukast inhibits the reaction [ABCC1 protein results in increased transport of estradiol-17 beta-glucuronide]; verlukast inhibits the reaction [ABCC1 protein results in increased transport of zearalenol]; verlukast inhibits the reaction [ABCC1 protein results in increased transport of Zearalenone]; verlukast inhibits the reaction [Prostaglandins E results in increased activity of ABCC1 protein]; verlukast inhibits the reaction [Quercetin results in increased activity of ABCC1 protein]
[Epinephrine co-treated with [verlukast results in decreased activity of ABCC1 protein]] results in increased abundance of Glutathione Disulfide; [verlukast results in decreased activity of ABCC1 protein] inhibits the reaction [Arsenates results in increased export of Glutathione]; [verlukast results in decreased activity of ABCC1 protein] which promotes the reaction and affects the abundance of Epinephrine metabolite; [verlukast results in decreased activity of ABCC1 protein] which results in increased uptake of Vincristine
CTD PMID:10025956 PMID:10685512 PMID:11331074 PMID:12893836 PMID:15041478 More... NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601
JBrowse link
G Abcc2 ATP-binding cassette, sub-family member 2 decreases activity
multiple interactions
ISO verlukast results in decreased activity of ABCC2 protein
verlukast results in decreased activity of ABCC2 protein; verlukast results in decreased activity of ABCC2 protein modified form
[verlukast results in decreased activity of ABCC2 protein] which results in decreased secretion of Resveratrol metabolite; ABCC2 protein affects the reaction [verlukast results in decreased secretion of Chenodeoxycholic Acid]
[verlukast results in decreased activity of ABCC2 protein] which results in decreased export of Topotecan; [verlukast results in decreased activity of ABCC2 protein] which results in decreased transport of benzoylaconine; [verlukast results in decreased activity of ABCC2 protein] which results in decreased transport of benzoylhypaconine; [verlukast results in decreased activity of ABCC2 protein] which results in decreased transport of benzoylmesaconine; [verlukast results in decreased activity of ABCC2 protein] which results in decreased transport of hypaconitine; [verlukast results in decreased activity of ABCC2 protein] which results in decreased transport of mesaconitine; [verlukast results in decreased activity of ABCC2 protein] which results in increased uptake of Vinblastine; verlukast inhibits the reaction [[Adenosine Triphosphate co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide]; verlukast inhibits the reaction [ABCC2 protein results in increased export of calcein AM]; verlukast inhibits the reaction [ABCC2 protein results in increased export of Paclitaxel]; verlukast inhibits the reaction [ABCC2 protein results in increased export of Saquinavir]; verlukast inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; verlukast inhibits the reaction [ABCC2 protein results in increased transport of Leukotriene C4]; verlukast inhibits the reaction [ABCC2 protein results in increased transport of zearalenol]; verlukast inhibits the reaction [ABCC2 protein results in increased transport of Zearalenone]; verlukast inhibits the reaction [Bucladesine results in increased activity of ABCC2 protein]
CTD PMID:15451006 PMID:15729621 PMID:15904671 PMID:16316932 PMID:19070657 More... NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179
JBrowse link
G Abcc3 ATP-binding cassette, sub-family C member 3 multiple interactions ISO verlukast inhibits the reaction [ABCC3 protein results in increased transport of calcein AM]; verlukast inhibits the reaction [ABCC3 protein results in increased transport of Leukotriene C4]; verlukast inhibits the reaction [ABCC3 protein results in increased transport of zearalenol] CTD PMID:19647055 PMID:27676153 NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823
JBrowse link
G Abcc4 ATP-binding cassette, sub-family C member 4 multiple interactions
decreases activity
ISO verlukast inhibits the reaction [ABCC4 protein affects the export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; verlukast inhibits the reaction [ABCC4 protein results in decreased susceptibility to Thioguanine]; verlukast inhibits the reaction [Prostaglandins E results in increased activity of ABCC4 protein]; verlukast inhibits the reaction [Quercetin results in increased activity of ABCC4 protein]
verlukast results in decreased activity of ABCC4 protein
CTD PMID:16004972 PMID:16156793 NCBI chr14:118,720,104...118,945,475
Ensembl chr14:118,720,104...118,943,631
JBrowse link
G Abcc5 ATP-binding cassette, sub-family C member 5 multiple interactions ISO verlukast inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein] CTD PMID:16156793 NCBI chr16:20,150,053...20,245,178
Ensembl chr16:20,150,053...20,245,144
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) multiple interactions ISO verlukast inhibits the reaction [ABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloride] CTD PMID:12869632 NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661
JBrowse link
G Ar androgen receptor multiple interactions ISO verlukast binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:97,192,363...97,366,824
Ensembl chr  X:97,192,375...97,366,821
JBrowse link
G Casp3 caspase 3 multiple interactions ISO verlukast promotes the reaction [benzyl isothiocyanate results in increased activity of and results in increased cleavage of CASP3 protein] CTD PMID:33880814 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 multiple interactions EXP verlukast inhibits the reaction [Ovalbumin results in increased expression of CCL11 mRNA] CTD PMID:12794006 NCBI chr11:81,948,658...81,953,781
Ensembl chr11:81,948,649...81,953,781
JBrowse link
G Ccl12 C-C motif chemokine ligand 12 multiple interactions EXP verlukast inhibits the reaction [Ovalbumin results in increased expression of CCL12 mRNA] CTD PMID:12794006 NCBI chr11:81,992,671...81,994,225
Ensembl chr11:81,992,671...81,994,226
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP verlukast inhibits the reaction [Ovalbumin results in increased expression of CCL2 mRNA] CTD PMID:12794006 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO verlukast promotes the reaction [arsenic trioxide results in decreased activity of CYP1A1 protein] CTD PMID:12490585 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
JBrowse link
G Cysltr1 cysteinyl leukotriene receptor 1 multiple interactions ISO
EXP
alpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol inhibits the reaction [verlukast binds to and results in decreased activity of CYSLTR1 protein]; verlukast binds to and results in decreased activity of CYSLTR1 protein; verlukast inhibits the reaction [[Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]; verlukast inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]; verlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]
verlukast binds to and results in decreased activity of CYSLTR1 protein; verlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]
CTD PMID:8014876 PMID:8384568 PMID:10391245 PMID:10851239 PMID:11432448 More... NCBI chr  X:105,617,952...105,647,329
Ensembl chr  X:105,617,952...105,647,285
JBrowse link
G Cysltr2 cysteinyl leukotriene receptor 2 multiple interactions ISO verlukast binds to and results in decreased activity of CYSLTR2 protein; verlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR2 protein] CTD PMID:10851239 NCBI chr14:73,263,043...73,286,554
Ensembl chr14:73,263,043...73,286,554
JBrowse link
G Epx eosinophil peroxidase multiple interactions EXP verlukast inhibits the reaction [Ovalbumin results in increased expression of EPX protein] CTD PMID:12794006 NCBI chr11:87,754,824...87,766,362
Ensembl chr11:87,754,826...87,766,362
JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions ISO verlukast binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614
JBrowse link
G Esr2 estrogen receptor 2 (beta) multiple interactions ISO verlukast binds to and results in decreased activity of ESR2 protein CTD PMID:25752796 NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033
JBrowse link
G Fasl Fas ligand multiple interactions ISO verlukast promotes the reaction [FASL protein results in decreased abundance of Glutathione] CTD PMID:17724027 NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO [verlukast binds to and results in decreased activity of ABCC1 protein] inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein] CTD PMID:21728338 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 multiple interactions ISO verlukast inhibits the reaction [GSTP1 protein results in decreased susceptibility to Etoposide] CTD PMID:15999103 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985
JBrowse link
G Il13 interleukin 13 multiple interactions EXP
ISO
verlukast inhibits the reaction [Ovalbumin results in increased expression of IL13 mRNA]
verlukast inhibits the reaction [IL13 protein results in increased expression of MUC5AC protein]
CTD PMID:12654629 PMID:12794006 NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP verlukast inhibits the reaction [Bleomycin results in increased expression of IL1B protein] CTD PMID:17118201 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il4 interleukin 4 multiple interactions EXP verlukast inhibits the reaction [Ovalbumin results in increased expression of IL4 mRNA] CTD PMID:12794006 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO verlukast promotes the reaction [benzyl isothiocyanate results in increased phosphorylation of MAPK1 protein] CTD PMID:33880814 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO verlukast promotes the reaction [benzyl isothiocyanate results in increased phosphorylation of MAPK3 protein] CTD PMID:33880814 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP verlukast inhibits the reaction [Bleomycin results in increased activity of MPO protein]; verlukast inhibits the reaction [Ovalbumin results in increased expression of MPO protein] CTD PMID:12794006 PMID:17118201 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239
JBrowse link
G Muc5ac mucin 5, subtypes A and C, tracheobronchial/gastric multiple interactions EXP
ISO
verlukast inhibits the reaction [Ovalbumin results in increased expression of MUC5AC mRNA]; verlukast inhibits the reaction [Ovalbumin results in increased expression of MUC5AC protein]
verlukast inhibits the reaction [IL13 protein results in increased expression of MUC5AC protein]; verlukast inhibits the reaction [Leukotriene D4 results in increased expression of MUC5AC mRNA]; verlukast inhibits the reaction [Leukotriene D4 results in increased expression of MUC5AC protein]
CTD PMID:12654629 PMID:12794006 NCBI chr 7:141,342,695...141,372,964
Ensembl chr 7:141,342,709...141,372,968
JBrowse link
G Slc22a8 solute carrier family 22 (organic anion transporter), member 8 multiple interactions ISO verlukast inhibits the reaction [SLC22A8 protein results in increased uptake of Enalaprilat] CTD PMID:33007874 NCBI chr19:8,568,576...8,589,199
Ensembl chr19:8,568,618...8,589,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP verlukast inhibits the reaction [Bleomycin results in increased expression of TNF protein] CTD PMID:17118201 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 multiple interactions ISO verlukast inhibits the reaction [UGT1A1 protein results in increased glucuronidation of anhydroicaritin] CTD PMID:30237061 NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22194
    chemical entity 22193
      molecular entity 22185
        polyatomic entity 22088
          molecule 21686
            organic molecule 21662
              organic cyclic compound 21269
                organic aromatic compound 20751
                  quinolines 2654
                    MK 571 33
Path 2
Term Annotations click to browse term
  CHEBI ontology 22194
    subatomic particle 22186
      composite particle 22186
        hadron 22186
          baryon 22186
            nucleon 22186
              atomic nucleus 22186
                atom 22186
                  main group element atom 22120
                    p-block element atom 22120
                      carbon group element atom 21920
                        carbon atom 21846
                          organic molecular entity 21846
                            organic molecule 21662
                              organic cyclic compound 21269
                                organic heterocyclic compound 20342
                                  organonitrogen heterocyclic compound 19086
                                    quinolines 2654
                                      MK 571 33
paths to the root