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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:MK 571
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Accession:CHEBI:6619 term browser browse the term
Definition:A quinoline that has formula C26H27ClN2O3S2.
Synonyms:related_synonym: Formula=C26H27ClN2O3S2;   InChI=1S/C26H27ClN2O3S2/c1-29(2)24(30)12-14-33-26(34-15-13-25(31)32)20-5-3-4-18(16-20)6-10-22-11-8-19-7-9-21(27)17-23(19)28-22/h3-11,16-17,26H,12-15H2,1-2H3,(H,31,32)/b10-6+;   InChIKey=AXUZQJFHDNNPFG-UXBLZVDNSA-N;   SMILES=CN(C)C(=O)CCSC(SCCC(O)=O)c1cccc(\\C=C\\c2ccc3ccc(Cl)cc3n2)c1;   Verlukast
 xref: CAS:115104-28-4;   KEGG:C11239
 xref_mesh: MESH:C059141


show annotations for term's descendants           Sort by:
MK 571 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca8 ATP binding cassette subfamily A member 8 multiple interactions ISO verlukast inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide] CTD PMID:12379217 NCBI chr10:94,917,520...94,991,199
Ensembl chr10:94,917,520...94,990,988 		JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions		 ISO verlukast results in decreased activity of ABCB11 protein
verlukast inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]		 CTD PMID:20829430 PMID:23956101 PMID:24014644 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity ISO verlukast results in decreased activity of ABCB1 protein CTD PMID:16316932 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions
decreases activity		 ISO
EXP		 [verlukast affects the activity of ABCC1 protein] which results in increased abundance of fluorexon; [verlukast binds to and results in decreased activity of ABCC1 protein] inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]; [verlukast results in decreased activity of ABCC1 protein] which results in decreased export of calcein AM; [verlukast results in decreased activity of ABCC1 protein] which results in decreased export of Daunorubicin; [verlukast results in decreased activity of ABCC1 protein] which results in increased susceptibility to Arsenic Trioxide; verlukast inhibits the reaction [ABCC1 protein affects the export of fluorexon]; verlukast inhibits the reaction [ABCC1 protein affects the transport of Bilirubin]; verlukast inhibits the reaction [ABCC1 protein affects the transport of S-(2,4-dinitrophenyl)glutathione]; verlukast inhibits the reaction [ABCC1 protein mutant form results in increased transport of estradiol-17 beta-glucuronide]; verlukast inhibits the reaction [ABCC1 protein results in decreased susceptibility to Antimony Potassium Tartrate]; verlukast inhibits the reaction [ABCC1 protein results in decreased susceptibility to Arsenic Trioxide]; verlukast inhibits the reaction [ABCC1 protein results in decreased susceptibility to Doxorubicin]; verlukast inhibits the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; verlukast inhibits the reaction [ABCC1 protein results in decreased susceptibility to Mercuric Chloride]; verlukast inhibits the reaction [ABCC1 protein results in decreased susceptibility to sodium arsenate]; verlukast inhibits the reaction [ABCC1 protein results in decreased susceptibility to Vincristine]; verlukast inhibits the reaction [ABCC1 protein results in decreased uptake of and results in decreased susceptibility to Arsenic Trioxide]; verlukast inhibits the reaction [ABCC1 protein results in increased export of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein]; verlukast inhibits the reaction [ABCC1 protein results in increased export of Daunorubicin]; verlukast inhibits the reaction [ABCC1 protein results in increased export of fluorexon]; verlukast inhibits the reaction [ABCC1 protein results in increased export of Methylmercury Compounds]; verlukast inhibits the reaction [ABCC1 protein results in increased secretion of Antimony Potassium Tartrate]; verlukast inhibits the reaction [ABCC1 protein results in increased transport of calcein AM]; verlukast inhibits the reaction [ABCC1 protein results in increased transport of estradiol-17 beta-glucuronide]; verlukast inhibits the reaction [ABCC1 protein results in increased transport of zearalenol]; verlukast inhibits the reaction [ABCC1 protein results in increased transport of Zearalenone]; verlukast inhibits the reaction [Prostaglandins E results in increased activity of ABCC1 protein]; verlukast inhibits the reaction [Quercetin results in increased activity of ABCC1 protein]
[Epinephrine co-treated with [verlukast results in decreased activity of ABCC1 protein]] results in increased abundance of Glutathione Disulfide; [verlukast results in decreased activity of ABCC1 protein] inhibits the reaction [Arsenates results in increased export of Glutathione]; [verlukast results in decreased activity of ABCC1 protein] which promotes the reaction and affects the abundance of Epinephrine metabolite; [verlukast results in decreased activity of ABCC1 protein] which results in increased uptake of Vincristine		 CTD PMID:10025956 PMID:10685512 PMID:11331074 PMID:12893836 PMID:15041478 More... NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases activity
multiple interactions		 ISO
EXP		 verlukast results in decreased activity of ABCC2 protein
[verlukast results in decreased activity of ABCC2 protein] which results in decreased secretion of Resveratrol metabolite; ABCC2 protein affects the reaction [verlukast results in decreased secretion of Chenodeoxycholic Acid]
verlukast results in decreased activity of ABCC2 protein; verlukast results in decreased activity of ABCC2 protein modified form
[verlukast results in decreased activity of ABCC2 protein] which results in decreased export of Topotecan; [verlukast results in decreased activity of ABCC2 protein] which results in decreased transport of benzoylaconine; [verlukast results in decreased activity of ABCC2 protein] which results in decreased transport of benzoylhypaconine; [verlukast results in decreased activity of ABCC2 protein] which results in decreased transport of benzoylmesaconine; [verlukast results in decreased activity of ABCC2 protein] which results in decreased transport of hypaconitine; [verlukast results in decreased activity of ABCC2 protein] which results in decreased transport of mesaconitine; [verlukast results in decreased activity of ABCC2 protein] which results in increased uptake of Vinblastine; verlukast inhibits the reaction [[Adenosine Triphosphate co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide]; verlukast inhibits the reaction [ABCC2 protein results in increased export of calcein AM]; verlukast inhibits the reaction [ABCC2 protein results in increased export of Paclitaxel]; verlukast inhibits the reaction [ABCC2 protein results in increased export of Saquinavir]; verlukast inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; verlukast inhibits the reaction [ABCC2 protein results in increased transport of Leukotriene C4]; verlukast inhibits the reaction [ABCC2 protein results in increased transport of zearalenol]; verlukast inhibits the reaction [ABCC2 protein results in increased transport of Zearalenone]; verlukast inhibits the reaction [Bucladesine results in increased activity of ABCC2 protein]		 CTD PMID:15451006 PMID:15729621 PMID:15904671 PMID:16316932 PMID:19070657 More... NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO verlukast inhibits the reaction [ABCC3 protein results in increased transport of calcein AM]; verlukast inhibits the reaction [ABCC3 protein results in increased transport of Leukotriene C4]; verlukast inhibits the reaction [ABCC3 protein results in increased transport of zearalenol] CTD PMID:19647055 PMID:27676153 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions
decreases activity		 ISO verlukast inhibits the reaction [ABCC4 protein affects the export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; verlukast inhibits the reaction [ABCC4 protein results in decreased susceptibility to Thioguanine]; verlukast inhibits the reaction [Prostaglandins E results in increased activity of ABCC4 protein]; verlukast inhibits the reaction [Quercetin results in increased activity of ABCC4 protein]
verlukast results in decreased activity of ABCC4 protein		 CTD PMID:16004972 PMID:16156793 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 multiple interactions ISO verlukast inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein] CTD PMID:16156793 NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO verlukast inhibits the reaction [ABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloride] CTD PMID:12869632 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Ar androgen receptor multiple interactions ISO verlukast binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO verlukast promotes the reaction [benzyl isothiocyanate results in increased activity of and results in increased cleavage of CASP3 protein] CTD PMID:33880814 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccl11 C-C motif chemokine ligand 11 multiple interactions ISO verlukast inhibits the reaction [Ovalbumin results in increased expression of CCL11 mRNA] CTD PMID:12794006 NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926 		JBrowse link
G Ccl12 C-C motif chemokine ligand 12 multiple interactions ISO verlukast inhibits the reaction [Ovalbumin results in increased expression of CCL12 mRNA] CTD PMID:12794006 NCBI chr10:67,070,230...67,071,780
Ensembl chr10:67,070,230...67,071,780 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO verlukast inhibits the reaction [Ovalbumin results in increased expression of CCL2 mRNA] CTD PMID:12794006 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO verlukast promotes the reaction [arsenic trioxide results in decreased activity of CYP1A1 protein] CTD PMID:12490585 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cysltr1 cysteinyl leukotriene receptor 1 multiple interactions ISO alpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol inhibits the reaction [verlukast binds to and results in decreased activity of CYSLTR1 protein]; verlukast binds to and results in decreased activity of CYSLTR1 protein; verlukast inhibits the reaction [[Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]; verlukast inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]; verlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]
verlukast binds to and results in decreased activity of CYSLTR1 protein; verlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]		 CTD PMID:8014876 PMID:8384568 PMID:10391245 PMID:10851239 PMID:11432448 More... NCBI chr  X:71,661,421...71,690,012
Ensembl chr  X:71,663,821...71,690,121 		JBrowse link
G Cysltr2 cysteinyl leukotriene receptor 2 multiple interactions ISO verlukast binds to and results in decreased activity of CYSLTR2 protein; verlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR2 protein] CTD PMID:10851239 NCBI chr15:48,189,476...48,228,750
Ensembl chr15:48,189,073...48,304,136 		JBrowse link
G Epx eosinophil peroxidase multiple interactions ISO verlukast inhibits the reaction [Ovalbumin results in increased expression of EPX protein] CTD PMID:12794006 NCBI chr10:72,666,865...72,677,952
Ensembl chr10:72,666,865...72,677,952 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO verlukast binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO verlukast binds to and results in decreased activity of ESR2 protein CTD PMID:25752796 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Faslg Fas ligand multiple interactions ISO verlukast promotes the reaction [FASL protein results in decreased abundance of Glutathione] CTD PMID:17724027 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO [verlukast binds to and results in decreased activity of ABCC1 protein] inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein] CTD PMID:21728338 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO verlukast inhibits the reaction [GSTP1 protein results in decreased susceptibility to Etoposide] CTD PMID:15999103 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Il13 interleukin 13 multiple interactions ISO
EXP		 verlukast inhibits the reaction [Ovalbumin results in increased expression of IL13 mRNA]
verlukast inhibits the reaction [IL13 protein results in increased expression of MUC5AC protein]		 CTD PMID:12654629 PMID:12794006 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO verlukast inhibits the reaction [Bleomycin results in increased expression of IL1B protein] CTD PMID:17118201 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO verlukast inhibits the reaction [Ovalbumin results in increased expression of IL4 mRNA] CTD PMID:12794006 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO verlukast promotes the reaction [benzyl isothiocyanate results in increased phosphorylation of MAPK1 protein] CTD PMID:33880814 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO verlukast promotes the reaction [benzyl isothiocyanate results in increased phosphorylation of MAPK3 protein] CTD PMID:33880814 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO verlukast inhibits the reaction [Bleomycin results in increased activity of MPO protein]; verlukast inhibits the reaction [Ovalbumin results in increased expression of MPO protein] CTD PMID:12794006 PMID:17118201 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions ISO
EXP		 verlukast inhibits the reaction [Ovalbumin results in increased expression of MUC5AC mRNA]; verlukast inhibits the reaction [Ovalbumin results in increased expression of MUC5AC protein]
verlukast inhibits the reaction [IL13 protein results in increased expression of MUC5AC protein]; verlukast inhibits the reaction [Leukotriene D4 results in increased expression of MUC5AC mRNA]; verlukast inhibits the reaction [Leukotriene D4 results in increased expression of MUC5AC protein]		 CTD PMID:12654629 PMID:12794006 NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions ISO verlukast inhibits the reaction [SLC22A8 protein results in increased uptake of Enalaprilat] CTD PMID:33007874 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO verlukast inhibits the reaction [Bleomycin results in increased expression of TNF protein] CTD PMID:17118201 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions ISO verlukast inhibits the reaction [UGT1A1 protein results in increased glucuronidation of anhydroicaritin] CTD PMID:30237061 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    chemical entity 19909
      molecular entity 19880
        polyatomic entity 19862
          molecule 19752
            organic molecule 19737
              organic cyclic compound 19526
                organic aromatic compound 19390
                  quinolines 2665
                    MK 571 33
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      carbon group element atom 19766
                        carbon atom 19785
                          organic molecular entity 19785
                            organic molecule 19737
                              organic cyclic compound 19526
                                organic heterocyclic compound 18870
                                  organonitrogen heterocyclic compound 18174
                                    quinolines 2665
                                      MK 571 33
paths to the root