Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:MK 571
go back to main search page
Accession:CHEBI:6619 term browser browse the term
Definition:A quinoline that has formula C26H27ClN2O3S2.
Synonyms:related_synonym: Formula=C26H27ClN2O3S2;   InChI=1S/C26H27ClN2O3S2/c1-29(2)24(30)12-14-33-26(34-15-13-25(31)32)20-5-3-4-18(16-20)6-10-22-11-8-19-7-9-21(27)17-23(19)28-22/h3-11,16-17,26H,12-15H2,1-2H3,(H,31,32)/b10-6+;   InChIKey=AXUZQJFHDNNPFG-UXBLZVDNSA-N;   SMILES=CN(C)C(=O)CCSC(SCCC(O)=O)c1cccc(\\C=C\\c2ccc3ccc(Cl)cc3n2)c1;   Verlukast
 xref: CAS:115104-28-4;   KEGG:C11239
 xref_mesh: MESH:C059141


show annotations for term's descendants           Sort by:
 
MK 571 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca8 ATP binding cassette subfamily A member 8 multiple interactions ISO verlukast inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide] CTD PMID:12379217 NCBI chr10:98,236,919...98,308,288
Ensembl chr10:98,237,141...98,294,522
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions
ISO verlukast results in decreased activity of ABCB11 protein
verlukast inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
CTD PMID:20829430 PMID:23956101 PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity ISO verlukast results in decreased activity of ABCB1 protein CTD PMID:16316932 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions
decreases activity
ISO
EXP
[verlukast binds to and results in decreased activity of ABCC1 protein] inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]; [verlukast results in decreased activity of ABCC1 protein] which results in increased susceptibility to arsenic trioxide; verlukast inhibits the reaction [ABCC1 protein affects the export of fluorexon]; verlukast inhibits the reaction [ABCC1 protein affects the transport of Bilirubin]; verlukast inhibits the reaction [ABCC1 protein affects the transport of S-(2,4-dinitrophenyl)glutathione]; verlukast inhibits the reaction [ABCC1 protein mutant form results in increased transport of estradiol-17 beta-glucuronide]; verlukast inhibits the reaction [ABCC1 protein results in decreased susceptibility to Antimony Potassium Tartrate]; verlukast inhibits the reaction [ABCC1 protein results in decreased susceptibility to arsenic trioxide]; verlukast inhibits the reaction [ABCC1 protein results in decreased susceptibility to Doxorubicin]; verlukast inhibits the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; verlukast inhibits the reaction [ABCC1 protein results in decreased susceptibility to Mercuric Chloride]; verlukast inhibits the reaction [ABCC1 protein results in decreased susceptibility to sodium arsenate]; verlukast inhibits the reaction [ABCC1 protein results in decreased susceptibility to Vincristine]; verlukast inhibits the reaction [ABCC1 protein results in decreased uptake of and results in decreased susceptibility to arsenic trioxide]; verlukast inhibits the reaction [ABCC1 protein results in increased export of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein]; verlukast inhibits the reaction [ABCC1 protein results in increased export of fluorexon]; verlukast inhibits the reaction [ABCC1 protein results in increased secretion of Antimony Potassium Tartrate]; verlukast inhibits the reaction [ABCC1 protein results in increased transport of calcein AM]; verlukast inhibits the reaction [ABCC1 protein results in increased transport of estradiol-17 beta-glucuronide]; verlukast inhibits the reaction [ABCC1 protein results in increased transport of zearalenol]; verlukast inhibits the reaction [ABCC1 protein results in increased transport of Zearalenone]; verlukast inhibits the reaction [Prostaglandins E results in increased activity of ABCC1 protein]; verlukast inhibits the reaction [Quercetin results in increased activity of ABCC1 protein]
[Epinephrine co-treated with [verlukast results in decreased activity of ABCC1 protein]] results in increased abundance of Glutathione Disulfide; [verlukast results in decreased activity of ABCC1 protein] inhibits the reaction [Arsenates results in increased export of Glutathione]; [verlukast results in decreased activity of ABCC1 protein] which promotes the reaction and affects the abundance of Epinephrine metabolite; [verlukast results in decreased activity of ABCC1 protein] which results in increased uptake of Vincristine
CTD PMID:10025956 PMID:10685512 PMID:11331074 PMID:12893836 PMID:15041478 PMID:15180633 PMID:15245331 PMID:15451006 PMID:15694464 PMID:15804283 PMID:15916776 PMID:16004972 PMID:16049968 PMID:16101123 PMID:16156793 PMID:18336795 PMID:18633430 PMID:19053318 PMID:19647055 PMID:21728338 PMID:23052202 PMID:23542460 PMID:25058526 PMID:26454883 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases activity
multiple interactions
ISO
EXP
verlukast results in decreased activity of ABCC2 protein
[verlukast results in decreased activity of ABCC2 protein] which results in decreased export of Topotecan; [verlukast results in decreased activity of ABCC2 protein] which results in decreased transport of benzoylaconine; [verlukast results in decreased activity of ABCC2 protein] which results in decreased transport of benzoylhypaconine; [verlukast results in decreased activity of ABCC2 protein] which results in decreased transport of benzoylmesaconine; [verlukast results in decreased activity of ABCC2 protein] which results in decreased transport of hypaconitine; [verlukast results in decreased activity of ABCC2 protein] which results in decreased transport of mesaconitine; [verlukast results in decreased activity of ABCC2 protein] which results in increased uptake of Vinblastine; verlukast inhibits the reaction [[Adenosine Triphosphate co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide]; verlukast inhibits the reaction [ABCC2 protein results in increased export of calcein AM]; verlukast inhibits the reaction [ABCC2 protein results in increased export of Paclitaxel]; verlukast inhibits the reaction [ABCC2 protein results in increased export of Saquinavir]; verlukast inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; verlukast inhibits the reaction [ABCC2 protein results in increased transport of Leukotriene C4]; verlukast inhibits the reaction [ABCC2 protein results in increased transport of zearalenol]; verlukast inhibits the reaction [ABCC2 protein results in increased transport of Zearalenone]; verlukast inhibits the reaction [Bucladesine results in increased activity of ABCC2 protein]
verlukast results in decreased activity of ABCC2 protein; verlukast results in decreased activity of ABCC2 protein modified form
[verlukast results in decreased activity of ABCC2 protein] which results in decreased secretion of Resveratrol metabolite; ABCC2 protein affects the reaction [verlukast results in decreased secretion of Chenodeoxycholic Acid]
CTD PMID:15451006 PMID:15729621 PMID:15904671 PMID:16316932 PMID:19070657 PMID:19505989 PMID:19647055 PMID:19952419 PMID:20089784 PMID:20457140 PMID:21262925 PMID:23200901 PMID:25844889 PMID:27676153 PMID:29052767 PMID:32003934 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO verlukast inhibits the reaction [ABCC3 protein results in increased transport of calcein AM]; verlukast inhibits the reaction [ABCC3 protein results in increased transport of Leukotriene C4]; verlukast inhibits the reaction [ABCC3 protein results in increased transport of zearalenol] CTD PMID:19647055 PMID:27676153 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions
decreases activity
ISO verlukast inhibits the reaction [ABCC4 protein affects the export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; verlukast inhibits the reaction [ABCC4 protein results in decreased susceptibility to Thioguanine]; verlukast inhibits the reaction [Prostaglandins E results in increased activity of ABCC4 protein]; verlukast inhibits the reaction [Quercetin results in increased activity of ABCC4 protein]
verlukast results in decreased activity of ABCC4 protein
CTD PMID:16004972 PMID:16156793 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 multiple interactions ISO verlukast inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein] CTD PMID:16156793 NCBI chr11:84,395,982...84,490,215
Ensembl chr11:84,396,033...84,490,211
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO verlukast inhibits the reaction [ABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloride] CTD PMID:12869632 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Ar androgen receptor multiple interactions ISO verlukast binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 multiple interactions ISO verlukast inhibits the reaction [Ovalbumin results in increased expression of CCL11 mRNA] CTD PMID:12794006 NCBI chr10:69,434,965...69,439,566
Ensembl chr10:69,434,941...69,439,575
JBrowse link
G Ccl12 chemokine (C-C motif) ligand 12 multiple interactions ISO verlukast inhibits the reaction [Ovalbumin results in increased expression of CCL12 mRNA] CTD PMID:12794006 NCBI chr10:69,476,866...69,478,416
Ensembl chr10:69,476,775...69,478,462
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO verlukast inhibits the reaction [Ovalbumin results in increased expression of CCL2 mRNA] CTD PMID:12794006 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO verlukast promotes the reaction [arsenic trioxide results in decreased activity of CYP1A1 protein] CTD PMID:12490585 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cysltr1 cysteinyl leukotriene receptor 1 multiple interactions ISO alpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol inhibits the reaction [verlukast binds to and results in decreased activity of CYSLTR1 protein]; verlukast binds to and results in decreased activity of CYSLTR1 protein; verlukast inhibits the reaction [[Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]; verlukast inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]; verlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]
verlukast binds to and results in decreased activity of CYSLTR1 protein; verlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]
CTD PMID:8014876 PMID:8384568 PMID:10391245 PMID:10851239 PMID:11432448 PMID:11705452 PMID:12629151 PMID:14718577 NCBI chr  X:77,671,028...77,700,491
Ensembl chr  X:77,674,150...77,700,269
JBrowse link
G Cysltr2 cysteinyl leukotriene receptor 2 multiple interactions ISO verlukast binds to and results in decreased activity of CYSLTR2 protein; verlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR2 protein] CTD PMID:10851239 NCBI chr15:54,903,290...54,941,742
Ensembl chr15:54,905,274...54,906,203
JBrowse link
G Epx eosinophil peroxidase multiple interactions ISO verlukast inhibits the reaction [Ovalbumin results in increased expression of EPX protein] CTD PMID:12794006 NCBI chr10:75,160,690...75,171,774
Ensembl chr10:75,160,690...75,171,774
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO verlukast binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO verlukast binds to and results in decreased activity of ESR2 protein CTD PMID:25752796 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Faslg Fas ligand multiple interactions ISO verlukast promotes the reaction [FASL protein results in decreased abundance of Glutathione] CTD PMID:17724027 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO [verlukast binds to and results in decreased activity of ABCC1 protein] inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein] CTD PMID:21728338 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO verlukast inhibits the reaction [GSTP1 protein results in decreased susceptibility to Etoposide] CTD PMID:15999103 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Il13 interleukin 13 multiple interactions ISO
EXP
verlukast inhibits the reaction [Ovalbumin results in increased expression of IL13 mRNA]
verlukast inhibits the reaction [IL13 protein results in increased expression of MUC5AC protein]
CTD PMID:12654629 PMID:12794006 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO verlukast inhibits the reaction [Bleomycin results in increased expression of IL1B protein] CTD PMID:17118201 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il4 interleukin 4 multiple interactions ISO verlukast inhibits the reaction [Ovalbumin results in increased expression of IL4 mRNA] CTD PMID:12794006 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO verlukast inhibits the reaction [Bleomycin results in increased activity of MPO protein]; verlukast inhibits the reaction [Ovalbumin results in increased expression of MPO protein] CTD PMID:12794006 PMID:17118201 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions ISO
EXP
verlukast inhibits the reaction [Ovalbumin results in increased expression of MUC5AC mRNA]; verlukast inhibits the reaction [Ovalbumin results in increased expression of MUC5AC protein]
verlukast inhibits the reaction [IL13 protein results in increased expression of MUC5AC protein]; verlukast inhibits the reaction [Leukotriene D4 results in increased expression of MUC5AC mRNA]; verlukast inhibits the reaction [Leukotriene D4 results in increased expression of MUC5AC protein]
CTD PMID:12654629 PMID:12794006 NCBI chr 1:214,725,482...214,756,653 JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO verlukast inhibits the reaction [Bleomycin results in increased expression of TNF protein] CTD PMID:17118201 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions ISO verlukast inhibits the reaction [UGT1A1 protein results in increased glucuronidation of anhydroicaritin] CTD PMID:30237061 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    chemical entity 19810
      molecular entity 19808
        polyatomic entity 19721
          molecule 19545
            organic molecule 19514
              organic cyclic compound 19311
                organic aromatic compound 19146
                  quinolines 2569
                    MK 571 29
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic molecule 19514
                              organic cyclic compound 19311
                                organic heterocyclic compound 18425
                                  organonitrogen heterocyclic compound 17481
                                    quinolines 2569
                                      MK 571 29
paths to the root