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ONTOLOGY REPORT - ANNOTATIONS


Term:sappanchalcone
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Accession:CHEBI:66172 term browser browse the term
Definition:A member of the class of chalcones that consists of trans-chalcone substituted by hydroxy groups at positions 3, 4 and 4' and a methoxy group at position 2'. Isolated from Caesalpinia sappan, it exhibits neuroprotective and cytoprotective activity.
Synonyms:exact_synonym: (2E)-3-(3,4-dihydroxyphenyl)-1-(4-hydroxy-2-methoxyphenyl)prop-2-en-1-one
 related_synonym: 3,4,4'-trihydroxy-2'-methoxychalcone;   Formula=C16H14O5;   InChI=1S/C16H14O5/c1-21-16-9-11(17)4-5-12(16)13(18)6-2-10-3-7-14(19)15(20)8-10/h2-9,17,19-20H,1H3/b6-2+;   InChIKey=JVGNTXGHBHMJDO-QHHAFSJGSA-N;   SMILES=COc1cc(O)ccc1C(=O)\\C=C\\c1ccc(O)c(O)c1
 xref: CAS:94344-54-4;   LIPID_MAPS_instance:LMPK12120114
 xref_mesh: MESH:C044363
 xref: PMID:19173220;   PMID:19420770;   PMID:20621084;   PMID:21963806;   Patent:KR20070060715;   Patent:KR20120007809;   Patent:WO2007066928;   Reaxys:5968372


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sappanchalcone term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6480464
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6480464
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19790
    role 19738
      chemical role 19269
        antioxidant 14224
          sappanchalcone 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19790
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19674
                    p-block element atom 19674
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18475
                              organic divalent group 18468
                                organodiyl group 18468
                                  carbonyl group 18366
                                    carbonyl compound 18366
                                      ketone 16011
                                        alpha,beta-unsaturated ketone 8525
                                          enone 8525
                                            chalcones 146
                                              chalcone 100
                                                trans-chalcone 100
                                                  sappanchalcone 8
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.