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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:jaspamide
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Accession:CHEBI:66104 term browser browse the term
Definition:A cyclodepsipeptide isolated from Jaspis splendens and has been shown to exhibit antineoplastic activity. It is an actin polymerization and stabilization inducer.
Synonyms:exact_synonym: (4R,7R,10S,13S,15E,17R,19S)-7-[(2-bromo-1H-indol-3-yl)methyl]-4-(4-hydroxyphenyl)-8,10,13,15,17,19-hexamethyl-1-oxa-5,8,11-triazacyclononadec-15-ene-2,6,9,12-tetrone
 related_synonym: Formula=C36H45BrN4O6;   InChI=1S/C36H45BrN4O6/c1-20-15-21(2)17-23(4)47-32(43)19-30(25-11-13-26(42)14-12-25)40-35(45)31(18-28-27-9-7-8-10-29(27)39-33(28)37)41(6)36(46)24(5)38-34(44)22(3)16-20/h7-15,21-24,30-31,39,42H,16-19H2,1-6H3,(H,38,44)(H,40,45)/b20-15+/t21-,22-,23-,24-,30+,31+/m0/s1;   InChIKey=GQWYWHOHRVVHAP-DHKPLNAMSA-N;   Jasplakinolide;   SMILES=C[C@H]1C[C@@H](C)\\C=C(C)\\C[C@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc2c(Br)[nH]c3ccccc23)C(=O)N[C@H](CC(=O)O1)c1ccc(O)cc1;   beta-Alanine, N-(2-bromo-N-(N-(8-hydroxy-2,4,6-trimethyl-1-oxo-4-nonenyl)-L-alanyl)-N-methyl-D-tryptophyl)-L-3-(4-hydroxyphenyl)-, p-lactone, (2S-(2R*,4E,6S*,8R*))-
 xref: CAS:102396-24-7;   KEGG:C16883;   KNApSAcK:C00026975
 xref_mesh: MESH:C057531
 xref: PMID:10339509;   PMID:11154977;   PMID:20678932;   PMID:21241058;   PMID:22115418;   PMID:23261645;   PMID:30736370;   PMID:3190203;   PMID:32084355;   PMID:33353294;   PMID:33515365;   PMID:34105487;   Patent:KR20030085421;   Reaxys:4649870


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jaspamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle, aorta increases expression ISO jasplakinolide results in increased expression of ACTA2 protein
jasplakinolide results in increased expression of ACTA2 mRNA		 CTD PMID:11035001 PMID:23517783 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990 		JBrowse link
G Actg1 actin, gamma, cytoplasmic 1 multiple interactions ISO jasplakinolide inhibits the reaction [UPF1 protein binds to ACTG1 protein]; jasplakinolide inhibits the reaction [UPF2 protein binds to ACTG1 protein]; jasplakinolide inhibits the reaction [UPF3B protein binds to ACTG1 protein] CTD PMID:28743738 NCBI chr11:120,236,513...120,239,321
Ensembl chr11:120,236,516...120,239,368 		JBrowse link
G Ahnak AHNAK nucleoprotein multiple interactions ISO jasplakinolide inhibits the reaction [AHNAK protein affects the expression of CDH1 protein]; jasplakinolide inhibits the reaction [AHNAK protein affects the expression of CDH2 protein]; jasplakinolide inhibits the reaction [AHNAK protein affects the expression of VIM protein]; jasplakinolide inhibits the reaction [AHNAK protein affects the localization of SNAI1 protein] CTD PMID:20388789 NCBI chr19:8,966,640...9,054,299
Ensembl chr19:8,966,648...9,054,278 		JBrowse link
G Ccn1 cellular communication network factor 1 multiple interactions
increases expression		 ISO jasplakinolide results in increased expression of and results in increased secretion of CCN1 protein; YAP1 protein affects the reaction [jasplakinolide results in increased expression of CCN1 protein]
jasplakinolide results in increased expression of CCN1 mRNA		 CTD PMID:24040060 NCBI chr 3:145,352,726...145,355,740
Ensembl chr 3:145,352,731...145,355,736 		JBrowse link
G Ccn2 cellular communication network factor 2 increases expression
multiple interactions		 ISO
EXP		 jasplakinolide results in increased expression of CCN2 mRNA
jasplakinolide results in increased expression of and results in increased secretion of CCN2 protein; YAP1 protein affects the reaction [jasplakinolide results in increased expression of CCN2 protein]		 CTD PMID:24040060 PMID:25690654 NCBI chr10:24,471,340...24,474,581
Ensembl chr10:24,471,340...24,474,581 		JBrowse link
G Cdh1 cadherin 1 decreases expression
multiple interactions		 ISO jasplakinolide results in decreased expression of CDH1 protein
jasplakinolide inhibits the reaction [AHNAK protein affects the expression of CDH1 protein]; jasplakinolide inhibits the reaction [EIF4E protein affects the expression of CDH1 protein]; jasplakinolide inhibits the reaction [S100A1 protein affects the expression of CDH1 protein]; jasplakinolide inhibits the reaction [SEPTIN9 protein affects the expression of CDH1 protein]		 CTD PMID:20388789 PMID:25756282 NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878 		JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO jasplakinolide inhibits the reaction [AHNAK protein affects the expression of CDH2 protein]; jasplakinolide inhibits the reaction [EIF4E protein affects the expression of CDH2 protein]; jasplakinolide inhibits the reaction [S100A1 protein affects the expression of CDH2 protein]; jasplakinolide inhibits the reaction [SEPTIN9 protein affects the expression of CDH2 protein] CTD PMID:20388789 NCBI chr18:16,721,934...16,942,303
Ensembl chr18:16,721,934...16,942,303 		JBrowse link
G Cdh5 cadherin 5 multiple interactions ISO jasplakinolide inhibits the reaction [Ethanol results in increased uptake of CDH5 protein] CTD PMID:22331491 NCBI chr 8:104,828,247...104,871,136
Ensembl chr 8:104,828,257...104,871,143 		JBrowse link
G Ctnna1 catenin alpha 1 multiple interactions ISO jasplakinolide affects the reaction [CTNNA1 protein affects the susceptibility to Cisplatin] CTD PMID:27989596 NCBI chr18:35,251,955...35,387,829
Ensembl chr18:35,251,912...35,387,832 		JBrowse link
G Diaph1 diaphanous related formin 1 affects localization EXP jasplakinolide affects the localization of DIAPH1 protein CTD PMID:22918941 NCBI chr18:37,976,654...38,068,573
Ensembl chr18:37,976,654...38,068,529 		JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions ISO jasplakinolide inhibits the reaction [EIF4E protein affects the expression of CDH1 protein]; jasplakinolide inhibits the reaction [EIF4E protein affects the expression of CDH2 protein]; jasplakinolide inhibits the reaction [EIF4E protein affects the expression of VIM protein]; jasplakinolide inhibits the reaction [EIF4E protein affects the localization of SNAI1 protein] CTD PMID:20388789 NCBI chr 3:138,231,952...138,265,457
Ensembl chr 3:138,231,940...138,265,457 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression
multiple interactions		 ISO jasplakinolide results in increased expression of GDF15 mRNA; jasplakinolide results in increased expression of GDF15 protein
[SB 203580 co-treated with 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine] inhibits the reaction [jasplakinolide results in increased expression of GDF15 protein]		 CTD PMID:23996089 NCBI chr 8:71,082,043...71,085,106
Ensembl chr 8:71,082,043...71,085,106 		JBrowse link
G Gpx1 glutathione peroxidase 1 affects localization ISO jasplakinolide affects the localization of GPX1 mRNA mutant form CTD PMID:28743738 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO jasplakinolide inhibits the reaction [TNF protein affects the localization of ICAM1 protein] CTD PMID:15034928 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Ifng interferon gamma multiple interactions ISO jasplakinolide promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA] CTD PMID:12799187 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO jasplakinolide promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]
jasplakinolide inhibits the reaction [latrunculin B promotes the reaction [IL1B protein results in increased expression of NOS2 protein]]		 CTD PMID:11502570 PMID:12799187 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Mrtfa myocardin related transcription factor A affects localization ISO jasplakinolide affects the localization of MRTFA protein CTD PMID:23517783 NCBI chr15:80,896,482...81,074,937
Ensembl chr15:80,896,482...81,074,958 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO jasplakinolide promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]
jasplakinolide inhibits the reaction [latrunculin B promotes the reaction [IL1B protein results in increased expression of NOS2 protein]]		 CTD PMID:11502570 PMID:12799187 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G P2rx1 purinergic receptor P2X, ligand-gated ion channel, 1 affects localization
multiple interactions		 ISO jasplakinolide affects the localization of P2RX1 protein
jasplakinolide inhibits the reaction [Cholesterol deficiency results in decreased activity of P2RX1 protein]		 CTD PMID:21757694 NCBI chr11:72,889,882...72,906,026
Ensembl chr11:72,889,929...72,906,026 		JBrowse link
G Rs1 retinoschisis (X-linked, juvenile) 1 (human) decreases secretion ISO jasplakinolide results in decreased secretion of RS1 protein CTD PMID:21738583 NCBI chr  X:159,548,815...159,584,800
Ensembl chr  X:159,551,009...159,582,659 		JBrowse link
G S100a1 S100 calcium binding protein A1 multiple interactions ISO jasplakinolide inhibits the reaction [S100A1 protein affects the expression of CDH1 protein]; jasplakinolide inhibits the reaction [S100A1 protein affects the expression of CDH2 protein]; jasplakinolide inhibits the reaction [S100A1 protein affects the expression of VIM protein]; jasplakinolide inhibits the reaction [S100A1 protein affects the localization of SNAI1 protein] CTD PMID:20388789 NCBI chr 3:90,418,341...90,421,637
Ensembl chr 3:90,418,341...90,421,699 		JBrowse link
G Septin9 septin 9 multiple interactions ISO jasplakinolide inhibits the reaction [SEPTIN9 protein affects the expression of CDH1 protein]; jasplakinolide inhibits the reaction [SEPTIN9 protein affects the expression of CDH2 protein]; jasplakinolide inhibits the reaction [SEPTIN9 protein affects the expression of VIM protein]; jasplakinolide inhibits the reaction [SEPTIN9 protein affects the localization of SNAI1 protein] CTD PMID:20388789 NCBI chr11:117,090,487...117,253,151
Ensembl chr11:117,090,487...117,253,151 		JBrowse link
G Snai1 snail family zinc finger 1 multiple interactions ISO jasplakinolide inhibits the reaction [AHNAK protein affects the localization of SNAI1 protein]; jasplakinolide inhibits the reaction [EIF4E protein affects the localization of SNAI1 protein]; jasplakinolide inhibits the reaction [S100A1 protein affects the localization of SNAI1 protein]; jasplakinolide inhibits the reaction [SEPTIN9 protein affects the localization of SNAI1 protein] CTD PMID:20388789 NCBI chr 2:167,380,115...167,384,734
Ensembl chr 2:167,380,115...167,384,734 		JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression ISO jasplakinolide results in decreased expression of SPP1 protein CTD PMID:19026636 NCBI chr 5:104,582,977...104,588,919
Ensembl chr 5:104,582,984...104,588,916 		JBrowse link
G Srf serum response factor increases activity ISO jasplakinolide results in increased activity of SRF protein CTD PMID:11502570 NCBI chr17:46,857,764...46,869,194
Ensembl chr17:46,859,255...46,867,101 		JBrowse link
G Tagln transgelin increases expression EXP
ISO		 jasplakinolide results in increased expression of TAGLN protein
jasplakinolide results in increased expression of TAGLN mRNA		 CTD PMID:11035001 PMID:15184395 NCBI chr 9:45,840,926...45,847,356
Ensembl chr 9:45,840,917...45,847,356 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO jasplakinolide inhibits the reaction [TNF protein affects the localization of ICAM1 protein]; jasplakinolide inhibits the reaction [TNF protein affects the localization of VCAM1 protein]; jasplakinolide promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA] CTD PMID:12799187 PMID:15034928 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Upf1 UPF1 RNA helicase and ATPase multiple interactions
affects localization		 ISO jasplakinolide inhibits the reaction [UPF1 protein binds to ACTG1 protein]
jasplakinolide affects the localization of UPF1 protein		 CTD PMID:28743738 NCBI chr 8:70,784,143...70,806,418
Ensembl chr 8:70,784,175...70,805,928 		JBrowse link
G Upf2 UPF2 regulator of nonsense transcripts homolog (yeast) multiple interactions ISO jasplakinolide inhibits the reaction [UPF2 protein binds to ACTG1 protein] CTD PMID:28743738 NCBI chr 2:5,956,218...6,061,514
Ensembl chr 2:5,956,280...6,061,514 		JBrowse link
G Upf3b UPF3 regulator of nonsense transcripts homolog B (yeast) multiple interactions
affects localization		 ISO jasplakinolide inhibits the reaction [UPF3B protein binds to ACTG1 protein]
jasplakinolide affects the localization of UPF3B protein		 CTD PMID:28743738 NCBI chr  X:36,355,331...36,374,124
Ensembl chr  X:36,355,331...36,373,975 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO jasplakinolide inhibits the reaction [TNF protein affects the localization of VCAM1 protein] CTD PMID:15034928 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337 		JBrowse link
G Vim vimentin multiple interactions ISO jasplakinolide inhibits the reaction [AHNAK protein affects the expression of VIM protein]; jasplakinolide inhibits the reaction [EIF4E protein affects the expression of VIM protein]; jasplakinolide inhibits the reaction [S100A1 protein affects the expression of VIM protein]; jasplakinolide inhibits the reaction [SEPTIN9 protein affects the expression of VIM protein] CTD PMID:20388789 NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637 		JBrowse link
G Yap1 yes-associated protein 1 multiple interactions ISO jasplakinolide results in decreased phosphorylation of and affects the localization of YAP1 protein; YAP1 protein affects the reaction [jasplakinolide results in increased expression of CCN1 protein]; YAP1 protein affects the reaction [jasplakinolide results in increased expression of CCN2 protein] CTD PMID:24040060 NCBI chr 9:7,932,000...8,004,890
Ensembl chr 9:7,932,000...8,004,597 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22194
    role 22179
      biological role 22178
        biochemical role 21449
          actin polymerisation inducer 33
            jaspamide 33
Path 2
Term Annotations click to browse term
  CHEBI ontology 22194
    subatomic particle 22186
      composite particle 22186
        hadron 22186
          baryon 22186
            nucleon 22186
              atomic nucleus 22186
                atom 22186
                  main group element atom 22120
                    p-block element atom 22120
                      carbon group element atom 21920
                        carbon atom 21846
                          organic molecular entity 21846
                            heteroorganic entity 21500
                              organochalcogen compound 20983
                                organooxygen compound 20824
                                  carbon oxoacid 19606
                                    carboxylic acid 19602
                                      carboacyl group 18299
                                        univalent carboacyl group 18299
                                          carbamoyl group 18110
                                            carboxamide 18110
                                              peptide 11233
                                                depsipeptide 4573
                                                  cyclodepsipeptide 4561
                                                    jaspamide 33
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