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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:jaspamide
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Accession:CHEBI:66104 term browser browse the term
Definition:A cyclodepsipeptide isolated from Jaspis splendens and has been shown to exhibit antineoplastic activity. It is an actin polymerization and stabilization inducer.
Synonyms:exact_synonym: (4R,7R,10S,13S,15E,17R,19S)-7-[(2-bromo-1H-indol-3-yl)methyl]-4-(4-hydroxyphenyl)-8,10,13,15,17,19-hexamethyl-1-oxa-5,8,11-triazacyclononadec-15-ene-2,6,9,12-tetrone
 related_synonym: Formula=C36H45BrN4O6;   InChI=1S/C36H45BrN4O6/c1-20-15-21(2)17-23(4)47-32(43)19-30(25-11-13-26(42)14-12-25)40-35(45)31(18-28-27-9-7-8-10-29(27)39-33(28)37)41(6)36(46)24(5)38-34(44)22(3)16-20/h7-15,21-24,30-31,39,42H,16-19H2,1-6H3,(H,38,44)(H,40,45)/b20-15+/t21-,22-,23-,24-,30+,31+/m0/s1;   InChIKey=GQWYWHOHRVVHAP-DHKPLNAMSA-N;   Jasplakinolide;   SMILES=C[C@H]1C[C@@H](C)\\C=C(C)\\C[C@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc2c(Br)[nH]c3ccccc23)C(=O)N[C@H](CC(=O)O1)c1ccc(O)cc1;   beta-Alanine, N-(2-bromo-N-(N-(8-hydroxy-2,4,6-trimethyl-1-oxo-4-nonenyl)-L-alanyl)-N-methyl-D-tryptophyl)-L-3-(4-hydroxyphenyl)-, p-lactone, (2S-(2R*,4E,6S*,8R*))-
 xref: CAS:102396-24-7;   KEGG:C16883;   KNApSAcK:C00026975
 xref_mesh: MESH:C057531
 xref: PMID:10339509;   PMID:11154977;   PMID:20678932;   PMID:21241058;   PMID:22115418;   PMID:23261645;   PMID:30736370;   PMID:3190203;   PMID:32084355;   PMID:33353294;   PMID:33515365;   PMID:34105487;   Patent:KR20030085421;   Reaxys:4649870


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jaspamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle increases expression ISO
EXP
jasplakinolide results in increased expression of ACTA2 protein
jasplakinolide results in increased expression of ACTA2 mRNA
CTD PMID:11035001 PMID:23517783 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Actg1 actin, gamma 1 multiple interactions ISO jasplakinolide inhibits the reaction [UPF1 protein binds to ACTG1 protein]; jasplakinolide inhibits the reaction [UPF2 protein binds to ACTG1 protein]; jasplakinolide inhibits the reaction [UPF3B protein binds to ACTG1 protein] CTD PMID:28743738 NCBI chr10:105,619,738...105,622,587
Ensembl chr10:105,619,737...105,624,232
JBrowse link
G Ahnak AHNAK nucleoprotein multiple interactions ISO jasplakinolide inhibits the reaction [AHNAK protein affects the expression of CDH1 protein]; jasplakinolide inhibits the reaction [AHNAK protein affects the expression of CDH2 protein]; jasplakinolide inhibits the reaction [AHNAK protein affects the expression of VIM protein]; jasplakinolide inhibits the reaction [AHNAK protein affects the localization of SNAI1 protein] CTD PMID:20388789 NCBI chr 1:205,882,223...205,970,934
Ensembl chr 1:205,882,273...205,970,926
JBrowse link
G Ccn1 cellular communication network factor 1 multiple interactions
increases expression
ISO jasplakinolide results in increased expression of and results in increased secretion of CCN1 protein; YAP1 protein affects the reaction [jasplakinolide results in increased expression of CCN1 protein]
jasplakinolide results in increased expression of CCN1 mRNA
CTD PMID:24040060 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
JBrowse link
G Ccn2 cellular communication network factor 2 increases expression
multiple interactions
ISO jasplakinolide results in increased expression of CCN2 mRNA
jasplakinolide results in increased expression of and results in increased secretion of CCN2 protein; YAP1 protein affects the reaction [jasplakinolide results in increased expression of CCN2 protein]
CTD PMID:24040060 PMID:25690654 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Cdh1 cadherin 1 decreases expression
multiple interactions
ISO jasplakinolide results in decreased expression of CDH1 protein
jasplakinolide inhibits the reaction [AHNAK protein affects the expression of CDH1 protein]; jasplakinolide inhibits the reaction [EIF4E protein affects the expression of CDH1 protein]; jasplakinolide inhibits the reaction [S100A1 protein affects the expression of CDH1 protein]; jasplakinolide inhibits the reaction [SEPTIN9 protein affects the expression of CDH1 protein]
CTD PMID:20388789 PMID:25756282 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO jasplakinolide inhibits the reaction [AHNAK protein affects the expression of CDH2 protein]; jasplakinolide inhibits the reaction [EIF4E protein affects the expression of CDH2 protein]; jasplakinolide inhibits the reaction [S100A1 protein affects the expression of CDH2 protein]; jasplakinolide inhibits the reaction [SEPTIN9 protein affects the expression of CDH2 protein] CTD PMID:20388789 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Cdh5 cadherin 5 multiple interactions ISO jasplakinolide inhibits the reaction [Ethanol results in increased uptake of CDH5 protein] CTD PMID:22331491 NCBI chr19:815,415...854,478
Ensembl chr19:815,411...854,368
JBrowse link
G Ctnna1 catenin alpha 1 multiple interactions EXP jasplakinolide affects the reaction [CTNNA1 protein affects the susceptibility to Cisplatin] CTD PMID:27989596 NCBI chr18:26,728,246...26,860,911
Ensembl chr18:26,728,485...26,860,910
JBrowse link
G Diaph1 diaphanous-related formin 1 affects localization ISO jasplakinolide affects the localization of DIAPH1 protein CTD PMID:22918941 NCBI chr18:29,669,659...29,769,044
Ensembl chr18:29,669,659...29,769,172
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions ISO jasplakinolide inhibits the reaction [EIF4E protein affects the expression of CDH1 protein]; jasplakinolide inhibits the reaction [EIF4E protein affects the expression of CDH2 protein]; jasplakinolide inhibits the reaction [EIF4E protein affects the expression of VIM protein]; jasplakinolide inhibits the reaction [EIF4E protein affects the localization of SNAI1 protein] CTD PMID:20388789 NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression
multiple interactions
ISO jasplakinolide results in increased expression of GDF15 mRNA; jasplakinolide results in increased expression of GDF15 protein
[SB 203580 co-treated with 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine] inhibits the reaction [jasplakinolide results in increased expression of GDF15 protein]
CTD PMID:23996089 NCBI chr16:18,805,312...18,807,893
Ensembl chr16:18,805,239...18,808,055
JBrowse link
G Gpx1 glutathione peroxidase 1 affects localization ISO jasplakinolide affects the localization of GPX1 mRNA mutant form CTD PMID:28743738 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO jasplakinolide inhibits the reaction [TNF protein affects the localization of ICAM1 protein] CTD PMID:15034928 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifng interferon gamma multiple interactions ISO jasplakinolide promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA] CTD PMID:12799187 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
jasplakinolide promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]
jasplakinolide inhibits the reaction [latrunculin B promotes the reaction [IL1B protein results in increased expression of NOS2 protein]]
CTD PMID:11502570 PMID:12799187 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Mrtfa myocardin related transcription factor A affects localization ISO jasplakinolide affects the localization of MRTFA protein CTD PMID:23517783 NCBI chr 7:112,544,312...112,714,431
Ensembl chr 7:112,544,312...112,714,418
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
jasplakinolide promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]
jasplakinolide inhibits the reaction [latrunculin B promotes the reaction [IL1B protein results in increased expression of NOS2 protein]]
CTD PMID:11502570 PMID:12799187 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G P2rx1 purinergic receptor P2X 1 multiple interactions
affects localization
ISO jasplakinolide inhibits the reaction [Cholesterol deficiency results in decreased activity of P2RX1 protein]
jasplakinolide affects the localization of P2RX1 protein
CTD PMID:21757694 NCBI chr10:57,618,586...57,633,648
Ensembl chr10:57,618,586...57,633,623
JBrowse link
G Rs1 retinoschisin 1 decreases secretion ISO jasplakinolide results in decreased secretion of RS1 protein CTD PMID:21738583 NCBI chr  X:33,963,657...33,992,115
Ensembl chr  X:33,963,657...33,992,115
JBrowse link
G S100a1 S100 calcium binding protein A1 multiple interactions ISO jasplakinolide inhibits the reaction [S100A1 protein affects the expression of CDH1 protein]; jasplakinolide inhibits the reaction [S100A1 protein affects the expression of CDH2 protein]; jasplakinolide inhibits the reaction [S100A1 protein affects the expression of VIM protein]; jasplakinolide inhibits the reaction [S100A1 protein affects the localization of SNAI1 protein] CTD PMID:20388789 NCBI chr 2:175,993,922...175,998,765
Ensembl chr 2:175,993,922...175,999,544
JBrowse link
G Septin9 septin 9 multiple interactions ISO jasplakinolide inhibits the reaction [SEPTIN9 protein affects the expression of CDH1 protein]; jasplakinolide inhibits the reaction [SEPTIN9 protein affects the expression of CDH2 protein]; jasplakinolide inhibits the reaction [SEPTIN9 protein affects the expression of VIM protein]; jasplakinolide inhibits the reaction [SEPTIN9 protein affects the localization of SNAI1 protein] CTD PMID:20388789 NCBI chr10:102,409,798...102,579,056
Ensembl chr10:102,409,711...102,579,055
JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions ISO jasplakinolide inhibits the reaction [AHNAK protein affects the localization of SNAI1 protein]; jasplakinolide inhibits the reaction [EIF4E protein affects the localization of SNAI1 protein]; jasplakinolide inhibits the reaction [S100A1 protein affects the localization of SNAI1 protein]; jasplakinolide inhibits the reaction [SEPTIN9 protein affects the localization of SNAI1 protein] CTD PMID:20388789 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression ISO jasplakinolide results in decreased expression of SPP1 protein CTD PMID:19026636 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Srf serum response factor increases activity ISO jasplakinolide results in increased activity of SRF protein CTD PMID:11502570 NCBI chr 9:14,426,453...14,435,734
Ensembl chr 9:14,426,472...14,435,733
JBrowse link
G Tagln transgelin increases expression ISO
EXP
jasplakinolide results in increased expression of TAGLN protein
jasplakinolide results in increased expression of TAGLN mRNA
CTD PMID:11035001 PMID:15184395 NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO jasplakinolide inhibits the reaction [TNF protein affects the localization of ICAM1 protein]; jasplakinolide inhibits the reaction [TNF protein affects the localization of VCAM1 protein]; jasplakinolide promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA] CTD PMID:12799187 PMID:15034928 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Upf1 UPF1, RNA helicase and ATPase affects localization
multiple interactions
ISO jasplakinolide affects the localization of UPF1 protein
jasplakinolide inhibits the reaction [UPF1 protein binds to ACTG1 protein]
CTD PMID:28743738 NCBI chr16:19,076,594...19,097,365
Ensembl chr16:19,076,322...19,096,568
JBrowse link
G Upf2 UPF2, regulator of nonsense mediated mRNA decay multiple interactions ISO jasplakinolide inhibits the reaction [UPF2 protein binds to ACTG1 protein] CTD PMID:28743738 NCBI chr17:72,224,575...72,335,896
Ensembl chr17:72,225,316...72,335,855
JBrowse link
G Upf3b UPF3B, regulator of nonsense mediated mRNA decay multiple interactions
affects localization
ISO jasplakinolide inhibits the reaction [UPF3B protein binds to ACTG1 protein]
jasplakinolide affects the localization of UPF3B protein
CTD PMID:28743738 NCBI chr  X:116,335,308...116,353,332
Ensembl chr  X:116,335,308...116,353,236
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO jasplakinolide inhibits the reaction [TNF protein affects the localization of VCAM1 protein] CTD PMID:15034928 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Vim vimentin multiple interactions ISO jasplakinolide inhibits the reaction [AHNAK protein affects the expression of VIM protein]; jasplakinolide inhibits the reaction [EIF4E protein affects the expression of VIM protein]; jasplakinolide inhibits the reaction [S100A1 protein affects the expression of VIM protein]; jasplakinolide inhibits the reaction [SEPTIN9 protein affects the expression of VIM protein] CTD PMID:20388789 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Yap1 Yes1 associated transcriptional regulator multiple interactions ISO jasplakinolide results in decreased phosphorylation of and affects the localization of YAP1 protein; YAP1 protein affects the reaction [jasplakinolide results in increased expression of CCN1 protein]; YAP1 protein affects the reaction [jasplakinolide results in increased expression of CCN2 protein] CTD PMID:24040060 NCBI chr 8:5,095,705...5,166,808
Ensembl chr 8:5,095,722...5,167,010
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        biochemical role 19381
          actin polymerisation inducer 33
            jaspamide 33
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic acid 18364
                                        carboacyl group 17482
                                          univalent carboacyl group 17482
                                            carbamoyl group 17298
                                              carboxamide 17298
                                                peptide 9444
                                                  depsipeptide 356
                                                    cyclodepsipeptide 337
                                                      jaspamide 33
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