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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:isoimperatorin
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Accession:CHEBI:66071 term browser browse the term
Definition:A member of the class of psoralens that is psoralen substituted by a prenyloxy group at position 5. Isolated from Angelica dahurica and Angelica koreana, it acts as a acetylcholinesterase inhibitor.
Synonyms:exact_synonym: 4-[(3-methylbut-2-en-1-yl)oxy]-7H-furo[3,2-g]chromen-7-one
 related_synonym: 7,4-[(3-methyl-2-butenyl)oxy]-7H-furo[3,2-g]-1-benzopyran-7-one;   Formula=C16H14O4;   InChI=1S/C16H14O4/c1-10(2)5-7-19-16-11-3-4-15(17)20-14(11)9-13-12(16)6-8-18-13/h3-6,8-9H,7H2,1-2H3;   InChIKey=IGWDEVSBEKYORK-UHFFFAOYSA-N;   SMILES=CC(C)=CCOc1c2ccoc2cc2oc(=O)ccc12
 xref: CAS:482-45-1;   KEGG:C16976
 xref_mesh: MESH:C055542
 xref: PMID:12510838;   PMID:17396918;   PMID:20964319;   PMID:21627108;   Patent:CN102188464;   Reaxys:1291723


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isoimperatorin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP-binding cassette, sub-family C member 4 increases expression EXP isoimperatorin results in increased expression of ABCC4 mRNA CTD PMID:22173200 NCBI chr14:118,720,104...118,945,475
Ensembl chr14:118,720,104...118,943,631 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO isoimperatorin promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein] CTD PMID:16829687 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases oxidation ISO CYP1A2 protein results in increased oxidation of isoimperatorin CTD PMID:25500267 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
decreases activity		 ISO isoimperatorin inhibits the reaction [CYP1B1 protein results in increased oxidation of benzo(a)pyrene 7,8-dihydrodiol]
isoimperatorin results in decreased activity of CYP1B1 protein; isoimperatorin results in decreased activity of CYP1B1 protein polymorphism		 CTD PMID:15861043 NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490 		JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 increases oxidation
multiple interactions		 ISO CYP2B6 protein results in increased oxidation of isoimperatorin
[isoimperatorin co-treated with NADP] results in decreased activity of CYP2B6 protein; Mephenytoin inhibits the reaction [[isoimperatorin co-treated with NADP] results in decreased activity of CYP2B6 protein]		 CTD PMID:25500267 NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049 		JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 increases oxidation ISO CYP2D6 protein results in increased oxidation of isoimperatorin CTD PMID:25500267 NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461 		JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 increases expression EXP isoimperatorin results in increased expression of CYP3A11 protein CTD PMID:22173200 NCBI chr 5:145,791,417...145,816,664
Ensembl chr 5:145,791,236...145,816,774 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO isoimperatorin results in increased expression of HMOX1 CTD PMID:19642688 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 affects localization ISO isoimperatorin affects the localization of NFE2L2 protein CTD PMID:16829687 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Slc22a1 solute carrier family 22 (organic cation transporter), member 1 increases expression EXP isoimperatorin results in increased expression of SLC22A1 protein CTD PMID:22173200 NCBI chr17:12,867,761...12,894,725
Ensembl chr17:12,867,756...12,894,716 		JBrowse link
G Slc22a12 solute carrier family 22 (organic anion/cation transporter), member 12 decreases expression
increases expression		 EXP isoimperatorin results in decreased expression of SLC22A12 mRNA
isoimperatorin results in increased expression of SLC22A12 protein		 CTD PMID:22173200 NCBI chr19:6,585,884...6,593,100
Ensembl chr19:6,585,875...6,593,062 		JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 increases expression
decreases expression		 EXP isoimperatorin results in increased expression of SLC22A2 protein
isoimperatorin results in decreased expression of SLC22A2 mRNA		 CTD PMID:22173200 NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375 		JBrowse link
G Slc22a5 solute carrier family 22 (organic cation transporter), member 5 increases expression EXP isoimperatorin results in increased expression of SLC22A5 protein CTD PMID:22173200 NCBI chr11:53,755,368...53,782,609
Ensembl chr11:53,755,368...53,782,486 		JBrowse link
G Slc22a6 solute carrier family 22 (organic anion transporter), member 6 decreases expression EXP isoimperatorin results in decreased expression of SLC22A6 protein CTD PMID:22173200 NCBI chr19:8,595,360...8,605,663
Ensembl chr19:8,595,403...8,605,663 		JBrowse link
G Slc22a8 solute carrier family 22 (organic anion transporter), member 8 increases expression EXP isoimperatorin results in increased expression of SLC22A8 mRNA; isoimperatorin results in increased expression of SLC22A8 protein CTD PMID:22173200 NCBI chr19:8,568,576...8,589,199
Ensembl chr19:8,568,618...8,589,199 		JBrowse link
G Slc2a9 solute carrier family 2 (facilitated glucose transporter), member 9 increases expression
decreases expression		 EXP isoimperatorin results in increased expression of SLC2A9 mRNA
isoimperatorin results in decreased expression of SLC2A9 protein		 CTD PMID:22173200 NCBI chr 5:38,506,616...38,660,488
Ensembl chr 5:38,506,616...38,660,486 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    role 22194
      biological role 22162
        biochemical role 21431
          metabolite 21379
            isoimperatorin 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    p-block element atom 22104
                      carbon group element atom 21904
                        carbon atom 21859
                          organic molecular entity 21830
                            organic molecule 21647
                              organic cyclic compound 21252
                                organic heterocyclic compound 20352
                                  organic heteropolycyclic compound 19645
                                    organic heterotricyclic compound 16298
                                      furochromene 129
                                        furanocoumarin 129
                                          psoralens 117
                                            isoimperatorin 16
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