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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:9-hydroxycanthin-6-one
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Accession:CHEBI:66041 term browser browse the term
Definition:An indole alkaloid that is canthin-6-one substituted by a hydroxy group at position 9. Isolated from the roots of Eurycoma longifolia, it exhibits antineoplastic activity.
Synonyms:exact_synonym: 9-hydroxy-6H-indolo[3,2,1-de][1,5]naphthyridin-6-one
 related_synonym: Formula=C14H8N2O2;   InChI=1S/C14H8N2O2/c17-8-1-2-9-10-5-6-15-11-3-4-13(18)16(14(10)11)12(9)7-8/h1-7,17H;   InChIKey=JHPIJMUNSMWWAA-UHFFFAOYSA-N;   SMILES=Oc1ccc2c3ccnc4ccc(=O)n(c2c1)c34
 xref: Chemspider:23339751
 xref_mesh: MESH:C574274
 xref: PMID:11249106;   PMID:1800638;   PMID:21569213;   Reaxys:5340229



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9-hydroxycanthin-6-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases cleavage ISO 9-hydroxycanthin-6-one results in increased cleavage of CASP3 protein CTD PMID:29225138 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases cleavage ISO 9-hydroxycanthin-6-one results in increased cleavage of CASP8 protein CTD PMID:29225138 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases cleavage ISO 9-hydroxycanthin-6-one results in increased cleavage of CASP9 protein CTD PMID:29225138 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO 9-hydroxycanthin-6-one results in decreased expression of CCL2 mRNA CTD PMID:29225138 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO 9-hydroxycanthin-6-one results in decreased expression of CCL5 mRNA CTD PMID:29225138 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19759
      biological role 19759
        biochemical role 19379
          metabolite 19355
            9-hydroxycanthin-6-one 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19809
      composite particle 19809
        hadron 19809
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19706
                    p-block element atom 19706
                      carbon group element atom 19628
                        carbon atom 19618
                          organic molecular entity 19618
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18668
                                    carbonyl compound 18668
                                      ketone 16926
                                        alpha,beta-unsaturated ketone 9270
                                          enone 9270
                                            canthin-6-one 5
                                              9-hydroxycanthin-6-one 5
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