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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:eurycomanone
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Accession:CHEBI:65887 term browser browse the term
Definition:A quassinoid isolated from Eurycoma longifolia and has been shown to exhibit antineoplastic and antimalarial activties.
Synonyms:exact_synonym: (1beta,11beta,12alpha,15beta)-1,11,12,14,15-pentahydroxy-11,20-epoxypicrasa-3,13(21)-diene-2,16-dione
 related_synonym: Formula=C20H24O9;   InChI=1S/C20H24O9/c1-7-4-10(21)13(23)17(3)9(7)5-11-18-6-28-20(27,16(17)18)12(22)8(2)19(18,26)14(24)15(25)29-11/h4,9,11-14,16,22-24,26-27H,2,5-6H2,1,3H3/t9-,11+,12+,13+,14-,16+,17+,18+,19-,20+/m0/s1;   InChIKey=UCUWZJWAQQRCOR-AIMGAIMTSA-N;   Pasakbumin-A;   Picrasa-3,13(21)-diene-2,16-dione,11,2O-epoxy-1,11,12,14,15-pentahydroxy-,(1beta,11beta,12alpha,15beta)-,dihydrate;   SMILES=[H][C@@]12C[C@@]3([H])C(C)=CC(=O)[C@@H](O)[C@]3(C)[C@@]3([H])[C@]4(O)OC[C@@]13[C@@](O)([C@@H](O)C(=O)O2)C(=C)[C@H]4O
 xref: CAS:84633-29-4
 xref_mesh: MESH:C506425
 xref: PMID:1800638;   Reaxys:3635742


show annotations for term's descendants           Sort by:
eurycomanone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 decreases expression ISO eurycomanone results in decreased expression of ANXA1 mRNA; eurycomanone results in decreased expression of ANXA1 protein CTD PMID:21903368 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343 		JBrowse link
G Erp29 endoplasmic reticulum protein 29 decreases expression ISO eurycomanone results in decreased expression of ERP29 mRNA; eurycomanone results in decreased expression of ERP29 protein CTD PMID:21903368 NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376 		JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 decreases expression ISO eurycomanone results in decreased expression of HNRNPA2B1 protein CTD PMID:21903368 NCBI chr 4:80,534,659...80,545,297
Ensembl chr 4:80,534,651...80,545,249 		JBrowse link
G Phb1 prohibitin 1 decreases expression ISO eurycomanone results in decreased expression of PHB1 protein CTD PMID:21903368 NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042 		JBrowse link
G Tp53 tumor protein p53 decreases expression ISO eurycomanone results in decreased expression of TP53 protein CTD PMID:21903368 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19818
    role 19790
      biological role 19788
        biochemical role 19501
          metabolite 19486
            eurycomanone 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19818
    subatomic particle 19816
      composite particle 19816
        hadron 19816
          baryon 19816
            nucleon 19816
              atomic nucleus 19816
                atom 19816
                  main group element atom 19761
                    p-block element atom 19761
                      carbon group element atom 19703
                        carbon atom 19698
                          organic molecular entity 19698
                            organic group 18905
                              organic divalent group 18887
                                organodiyl group 18887
                                  carbonyl group 18853
                                    carbonyl compound 18853
                                      ketone 17140
                                        oxyketone 8803
                                          alpha-oxyketone 8803
                                            alpha-hydroxy ketone 8803
                                              secondary alpha-hydroxy ketone 1011
                                                eurycomanone 5
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