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Accession:CHEBI:65867 term browser browse the term
Definition:A naphthochromene that is 4H-naphtho[2,3-h]chromene which is substituted at position 2 by a (2R)-butan-2-yl group, at position 5 by a hydroxymethyl group, at position 11 by a hydroxy group, and at positions 4, 7, and 12 by oxogroups. An antibiotic isolated from Streptomyces sp. cu39, it exerts a potent protecting effect on neuronal cells through suppressing L-glutamate toxicity.
Synonyms:exact_synonym: 2-[(2R)-butan-2-yl]-11-hydroxy-5-(hydroxymethyl)-4H-naphtho[2,3-h]chromene-4,7,12-trione
 related_synonym: Formula=C22H18O6;   InChI=1S/C22H18O6/c1-3-10(2)16-8-15(25)17-11(9-23)7-13-19(22(17)28-16)21(27)18-12(20(13)26)5-4-6-14(18)24/h4-8,10,23-24H,3,9H2,1-2H3/t10-/m1/s1;   InChIKey=HXAZTNIVBVVFJS-SNVBAGLBSA-N;   SMILES=CC[C@@H](C)c1cc(=O)c2c(CO)cc3C(=O)c4cccc(O)c4C(=O)c3c2o1
 xref: PMID:8931733;   Reaxys:8804787

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  CHEBI ontology 856
    role 834
      biological role 834
        antimicrobial agent 216
          espicufolin 0
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    subatomic particle 841
      composite particle 841
        hadron 841
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              atomic nucleus 841
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                  main group element atom 829
                    p-block element atom 826
                      carbon group element atom 799
                        carbon atom 795
                          organic molecular entity 795
                            organic group 373
                              organic divalent group 371
                                organodiyl group 371
                                  carbonyl group 370
                                    carbonyl compound 370
                                      ketone 175
                                        cyclic ketone 159
                                          quinone 18
                                            p-quinones 18
                                              espicufolin 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.