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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ergosterol peroxide
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Accession:CHEBI:65858 term browser browse the term
Definition:An ergostanoid that is ergosta-6,22-dien-3-ol with a peroxy group between positions 5 and 8 (the 3beta,5alpha,8alpha,22E stereoisomer). Isolated from Ganoderma lucidum and Cordyceps sinensis, it exhibits antimycobacterial, trypanocidal and antineoplastic activities.
Synonyms:exact_synonym: (3S,5S,8S,9R,10R,13R,14R,17R)-17-[(2R,3E,5R)-5,6-dimethylhept-3-en-2-yl]-10,13-dimethyl-1,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-2H-5,8-epidioxycyclopenta[a]phenanthren-3-ol
 related_synonym: (22E,24R)-5alpha,8alpha-epidioxyergosta-6,22-dien-3beta-ol;   (24R)-5alpha,8alpha-epidioxy-24-methylcholesta-6,22-dien-3beta-ol;   (3beta,5alpha,8alpha,22E)-5,8-epidioxyergosta-6,22-dien-3-ol;   5alpha,8alpha-epidioxy-22E-ergosta-6,22-dien-3beta-ol;   Formula=C28H44O3;   InChI=1S/C28H44O3/c1-18(2)19(3)7-8-20(4)22-9-10-23-25(22,5)13-12-24-26(6)14-11-21(29)17-27(26)15-16-28(23,24)31-30-27/h7-8,15-16,18-24,29H,9-14,17H2,1-6H3/b8-7+/t19-,20+,21-,22+,23+,24+,25+,26+,27+,28-/m0/s1;   InChIKey=VXOZCESVZIRHCJ-KGHQQZOUSA-N;   SMILES=[H][C@@]1(CC[C@]2([H])[C@]1(C)CC[C@]1([H])[C@@]3(C)CC[C@H](O)C[C@@]33OO[C@@]21C=C3)[C@H](C)\\C=C\\[C@H](C)C(C)C;   ergosterol 5alpha,8alpha-epidioxide;   ergosterol endoperoxide;   ergosterol-5,8-peroxide;   peroxyergosterol
 xref: CAS:2061-64-5;   Chemspider:4508532
 xref_mesh: MESH:C036071
 xref: PMID:10423860;   PMID:11014261;   PMID:15665489;   PMID:21341709;   PMID:21428374;   PMID:21469696;   PMID:22083593;   PMID:9635497;   Reaxys:96852;   Wikipedia:Ergosterol_peroxide


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ergosterol peroxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO ergosterol-5,8-peroxide results in increased activity of CASP3 protein CTD PMID:20100469 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        biochemical role 19281
          metabolite 19262
            ergosterol peroxide 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                organic polycyclic compound 16384
                                  steroid 12788
                                    hydroxy steroid 12371
                                      3-hydroxy steroid 9999
                                        sterol 417
                                          phytosterols 68
                                            ergosterol 13
                                              ergosterol peroxide 1
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