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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ergosterol peroxide
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Accession:CHEBI:65858 term browser browse the term
Definition:An ergostanoid that is ergosta-6,22-dien-3-ol with a peroxy group between positions 5 and 8 (the 3beta,5alpha,8alpha,22E stereoisomer). Isolated from Ganoderma lucidum and Cordyceps sinensis, it exhibits antimycobacterial, trypanocidal and antineoplastic activities.
Synonyms:exact_synonym: (3S,5S,8S,9R,10R,13R,14R,17R)-17-[(2R,3E,5R)-5,6-dimethylhept-3-en-2-yl]-10,13-dimethyl-1,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-2H-5,8-epidioxycyclopenta[a]phenanthren-3-ol
 related_synonym: (22E,24R)-5alpha,8alpha-epidioxyergosta-6,22-dien-3beta-ol;   (24R)-5alpha,8alpha-epidioxy-24-methylcholesta-6,22-dien-3beta-ol;   (3beta,5alpha,8alpha,22E)-5,8-epidioxyergosta-6,22-dien-3-ol;   5alpha,8alpha-epidioxy-22E-ergosta-6,22-dien-3beta-ol;   Formula=C28H44O3;   InChI=1S/C28H44O3/c1-18(2)19(3)7-8-20(4)22-9-10-23-25(22,5)13-12-24-26(6)14-11-21(29)17-27(26)15-16-28(23,24)31-30-27/h7-8,15-16,18-24,29H,9-14,17H2,1-6H3/b8-7+/t19-,20+,21-,22+,23+,24+,25+,26+,27+,28-/m0/s1;   InChIKey=VXOZCESVZIRHCJ-KGHQQZOUSA-N;   SMILES=[H][C@@]1(CC[C@]2([H])[C@]1(C)CC[C@]1([H])[C@@]3(C)CC[C@H](O)C[C@@]33OO[C@@]21C=C3)[C@H](C)\\C=C\\[C@H](C)C(C)C;   ergosterol 5alpha,8alpha-epidioxide;   ergosterol endoperoxide;   ergosterol-5,8-peroxide;   peroxyergosterol
 xref: CAS:2061-64-5;   Chemspider:4508532
 xref_mesh: MESH:C036071
 xref: PMID:10423860;   PMID:11014261;   PMID:15665489;   PMID:21341709;   PMID:21428374;   PMID:21469696;   PMID:22083593;   PMID:9635497;   Reaxys:96852;   Wikipedia:Ergosterol_peroxide


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ergosterol peroxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO ergosterol-5,8-peroxide results in increased activity of CASP3 protein CTD PMID:20100469 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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  CHEBI ontology 19821
    role 19769
      biological role 19769
        biochemical role 19389
          metabolite 19364
            ergosterol peroxide 1
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  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic molecule 19569
                              organic cyclic compound 19360
                                organic polycyclic compound 16538
                                  steroid 13057
                                    hydroxy steroid 12658
                                      3-hydroxy steroid 10368
                                        sterol 439
                                          phytosterols 68
                                            ergosterol 13
                                              ergosterol peroxide 1
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