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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:eckol
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Accession:CHEBI:65819 term browser browse the term
Definition:A phlorotannin that is oxanthrene-1,3,6,8-tetrol substituted by a 3,5-dihydroxyphenoxy moiety at position 4. Isolated from the marine brown alga, Ecklonia cava, it exhibits antioxidant activity.
Synonyms:exact_synonym: 4-(3,5-dihydroxyphenoxy)oxanthrene-1,3,6,8-tetrol
 related_synonym: 1-(3,5-dihydroxyphenoxy)-2,4,7,9-tetrahydroxydibenzo-1,4-dioxin;   4-(3,5-dihydroxyphenoxy)-dibenzo(b,e)(1,4)dioxin-1,3,6,8-tetrol;   4-(3,5-dihydroxyphenoxy)dibenzo-p-dioxin-1,3,6,8-tetrol;   Formula=C18H12O9;   InChI=1S/C18H12O9/c19-7-1-8(20)3-10(2-7)25-16-12(23)6-13(24)17-18(16)27-15-11(22)4-9(21)5-14(15)26-17/h1-6,19-24H;   InChIKey=PCZZRBGISTUIOA-UHFFFAOYSA-N;   SMILES=Oc1cc(O)cc(Oc2c(O)cc(O)c3Oc4cc(O)cc(O)c4Oc23)c1
 xref: CAS:88798-74-7
 xref_mesh: MESH:C060311
 xref: PMID:17886227;   PMID:19201199;   PMID:19931411;   PMID:21514314;   PMID:22687478;   Reaxys:3635964;   Wikipedia:Eckol



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eckol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO eckol results in decreased phosphorylation of and results in decreased activity of AKT1 protein CTD PMID:21514314 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [eckol co-treated with temozolomide] results in increased cleavage of CASP8 protein CTD PMID:21514314 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Ctnnb1 catenin beta 1 decreases expression ISO eckol results in decreased expression of CTNNB1 protein CTD PMID:21514314 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Cybb cytochrome b-245 beta chain decreases expression ISO eckol results in decreased expression of CYBB protein CTD PMID:21514314 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Foxo3 forkhead box O3 increases phosphorylation
multiple interactions
ISO eckol results in increased phosphorylation of FOXO3 protein
FOXO3 mutant form inhibits the reaction [eckol results in increased expression of SOD2 protein]
CTD PMID:24700636 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO eckol results in decreased phosphorylation of and results in decreased activity of MAPK1 protein CTD PMID:21514314 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO eckol results in decreased phosphorylation of and results in decreased activity of MAPK3 protein CTD PMID:21514314 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Msi1 musashi RNA-binding protein 1 decreases expression ISO eckol results in decreased expression of MSI1 protein CTD PMID:21514314 NCBI chr12:41,158,301...41,251,134
Ensembl chr12:41,158,599...41,191,076
JBrowse link
G Nes nestin decreases expression ISO eckol results in decreased expression of NES protein CTD PMID:21514314 NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777
JBrowse link
G Prom1 prominin 1 decreases expression ISO eckol results in decreased expression of PROM1 protein CTD PMID:21514314 NCBI chr14:66,989,545...67,094,534
Ensembl chr14:66,990,160...67,094,527
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase decreases activity ISO eckol results in decreased activity of RAF1 protein CTD PMID:21514314 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression
ISO eckol inhibits the reaction [Hydrogen Peroxide results in decreased expression of and results in decreased activity of SOD2 protein]; FOXO3 mutant form inhibits the reaction [eckol results in increased expression of SOD2 protein]
eckol results in increased expression of SOD2 mRNA; eckol results in increased expression of SOD2 protein
CTD PMID:24700636 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sox2 SRY-box transcription factor 2 decreases expression ISO eckol results in decreased expression of SOX2 protein CTD PMID:21514314 NCBI chr 2:117,536,929...117,539,340
Ensembl chr 2:117,536,929...117,539,338
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19918
    role 19894
      chemical role 19512
        antioxidant 16062
          eckol 13
            7-phloroeckol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19811
                        carbon atom 19806
                          organic molecular entity 19806
                            organic molecule 19758
                              organic cyclic compound 19565
                                organic aromatic compound 19430
                                  phenols 18684
                                    polyphenol 9433
                                      tannin 303
                                        phlorotannin 49
                                          eckol 13
                                            7-phloroeckol 0
paths to the root