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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:eckol
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Accession:CHEBI:65819 term browser browse the term
Definition:A phlorotannin that is oxanthrene-1,3,6,8-tetrol substituted by a 3,5-dihydroxyphenoxy moiety at position 4. Isolated from the marine brown alga, Ecklonia cava, it exhibits antioxidant activity.
Synonyms:exact_synonym: 4-(3,5-dihydroxyphenoxy)oxanthrene-1,3,6,8-tetrol
 related_synonym: 1-(3,5-dihydroxyphenoxy)-2,4,7,9-tetrahydroxydibenzo-1,4-dioxin;   4-(3,5-dihydroxyphenoxy)-dibenzo(b,e)(1,4)dioxin-1,3,6,8-tetrol;   4-(3,5-dihydroxyphenoxy)dibenzo-p-dioxin-1,3,6,8-tetrol;   Formula=C18H12O9;   InChI=1S/C18H12O9/c19-7-1-8(20)3-10(2-7)25-16-12(23)6-13(24)17-18(16)27-15-11(22)4-9(21)5-14(15)26-17/h1-6,19-24H;   InChIKey=PCZZRBGISTUIOA-UHFFFAOYSA-N;   SMILES=Oc1cc(O)cc(Oc2c(O)cc(O)c3Oc4cc(O)cc(O)c4Oc23)c1
 xref: CAS:88798-74-7
 xref_mesh: MESH:C060311
 xref: PMID:17886227;   PMID:19201199;   PMID:19931411;   PMID:21514314;   PMID:22687478;   Reaxys:3635964;   Wikipedia:Eckol

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eckol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO eckol results in decreased phosphorylation of and results in decreased activity of AKT1 protein CTD PMID:21514314 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO [eckol co-treated with temozolomide] results in increased cleavage of CASP8 protein CTD PMID:21514314 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Ctnnb1 catenin beta 1 decreases expression ISO eckol results in decreased expression of CTNNB1 protein CTD PMID:21514314 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372 		JBrowse link
G Cybb cytochrome b-245 beta chain decreases expression ISO eckol results in decreased expression of CYBB protein CTD PMID:21514314 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547 		JBrowse link
G Foxo3 forkhead box O3 increases phosphorylation
multiple interactions		 ISO eckol results in increased phosphorylation of FOXO3 protein
FOXO3 mutant form inhibits the reaction [eckol results in increased expression of SOD2 protein]		 CTD PMID:24700636 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO eckol results in decreased phosphorylation of and results in decreased activity of MAPK1 protein CTD PMID:21514314 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO eckol results in decreased phosphorylation of and results in decreased activity of MAPK3 protein CTD PMID:21514314 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Msi1 musashi RNA-binding protein 1 decreases expression ISO eckol results in decreased expression of MSI1 protein CTD PMID:21514314 NCBI chr12:46,899,835...46,935,335
Ensembl chr12:46,895,447...46,920,952 		JBrowse link
G Nes nestin decreases expression ISO eckol results in decreased expression of NES protein CTD PMID:21514314 NCBI chr 2:187,343,109...187,352,972
Ensembl chr 2:187,344,056...187,352,969 		JBrowse link
G Prom1 prominin 1 decreases expression ISO eckol results in decreased expression of PROM1 protein CTD PMID:21514314 NCBI chr14:71,532,321...71,637,400
Ensembl chr14:71,533,063...71,637,417 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase decreases activity ISO eckol results in decreased activity of RAF1 protein CTD PMID:21514314 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression		 ISO eckol inhibits the reaction [Hydrogen Peroxide results in decreased expression of and results in decreased activity of SOD2 protein]; FOXO3 mutant form inhibits the reaction [eckol results in increased expression of SOD2 protein]
eckol results in increased expression of SOD2 mRNA; eckol results in increased expression of SOD2 protein		 CTD PMID:24700636 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G Sox2 SRY-box transcription factor 2 decreases expression ISO eckol results in decreased expression of SOX2 protein CTD PMID:21514314 NCBI chr 2:121,165,137...121,167,545
Ensembl chr 2:121,165,137...121,167,545 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19720
      chemical role 19260
        antioxidant 14254
          eckol 13
            7-phloroeckol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19580
                        carbon atom 19571
                          organic molecular entity 19571
                            organic molecule 19504
                              organic cyclic compound 19331
                                organic aromatic compound 19155
                                  phenols 18131
                                    polyphenol 6700
                                      tannin 217
                                        phlorotannin 41
                                          eckol 13
                                            7-phloroeckol 0
paths to the root