CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: eckol
Accession: CHEBI:65819
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Definition: A phlorotannin that is oxanthrene-1,3,6,8-tetrol substituted by a 3,5-dihydroxyphenoxy moiety at position 4. Isolated from the marine brown alga, Ecklonia cava, it exhibits antioxidant activity.
Synonyms: exact_synonym: 4-(3,5-dihydroxyphenoxy)oxanthrene-1,3,6,8-tetrol
related_synonym: 1-(3,5-dihydroxyphenoxy)-2,4,7,9-tetrahydroxydibenzo-1,4-dioxin; 4-(3,5-dihydroxyphenoxy)-dibenzo(b,e)(1,4)dioxin-1,3,6,8-tetrol; 4-(3,5-dihydroxyphenoxy)dibenzo-p-dioxin-1,3,6,8-tetrol; Formula=C18H12O9; InChI=1S/C18H12O9/c19-7-1-8(20)3-10(2-7)25-16-12(23)6-13(24)17-18(16)27-15-11(22)4-9(21)5-14(15)26-17/h1-6,19-24H; InChIKey=PCZZRBGISTUIOA-UHFFFAOYSA-N; SMILES=Oc1cc(O)cc(Oc2c(O)cc(O)c3Oc4cc(O)cc(O)c4Oc23)c1
xref: CAS:88798-74-7
xref_mesh: MESH:C060311
xref: PMID:17886227; PMID:19201199; PMID:19931411; PMID:21514314; PMID:22687478; Reaxys:3635964; Wikipedia:Eckol
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Akt1
AKT serine/threonine kinase 1
multiple interactions
ISO
eckol results in decreased phosphorylation of and results in decreased activity of AKT1 protein
CTD
PMID:21514314
NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
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Casp8
caspase 8
multiple interactions
ISO
[eckol co-treated with temozolomide] results in increased cleavage of CASP8 protein
CTD
PMID:21514314
NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
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Ctnnb1
catenin beta 1
decreases expression
ISO
eckol results in decreased expression of CTNNB1 protein
CTD
PMID:21514314
NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
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Cybb
cytochrome b-245 beta chain
decreases expression
ISO
eckol results in decreased expression of CYBB protein
CTD
PMID:21514314
NCBI chr X:14,578,330...14,610,049
Ensembl chr X:14,578,264...14,612,547
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Foxo3
forkhead box O3
increases phosphorylation multiple interactions
ISO
eckol results in increased phosphorylation of FOXO3 protein FOXO3 mutant form inhibits the reaction [eckol results in increased expression of SOD2 protein]
CTD
PMID:24700636
NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
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Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO
eckol results in decreased phosphorylation of and results in decreased activity of MAPK1 protein
CTD
PMID:21514314
NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
eckol results in decreased phosphorylation of and results in decreased activity of MAPK3 protein
CTD
PMID:21514314
NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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Msi1
musashi RNA-binding protein 1
decreases expression
ISO
eckol results in decreased expression of MSI1 protein
CTD
PMID:21514314
NCBI chr12:46,899,835...46,935,335
Ensembl chr12:46,895,447...46,920,952
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Nes
nestin
decreases expression
ISO
eckol results in decreased expression of NES protein
CTD
PMID:21514314
NCBI chr 2:187,343,109...187,352,972
Ensembl chr 2:187,344,056...187,352,969
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Prom1
prominin 1
decreases expression
ISO
eckol results in decreased expression of PROM1 protein
CTD
PMID:21514314
NCBI chr14:71,532,321...71,637,400
Ensembl chr14:71,533,063...71,637,417
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Raf1
Raf-1 proto-oncogene, serine/threonine kinase
decreases activity
ISO
eckol results in decreased activity of RAF1 protein
CTD
PMID:21514314
NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
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Sod2
superoxide dismutase 2
multiple interactions increases expression
ISO
eckol inhibits the reaction [Hydrogen Peroxide results in decreased expression of and results in decreased activity of SOD2 protein]; FOXO3 mutant form inhibits the reaction [eckol results in increased expression of SOD2 protein] eckol results in increased expression of SOD2 mRNA; eckol results in increased expression of SOD2 protein
CTD
PMID:24700636
NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
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Sox2
SRY-box transcription factor 2
decreases expression
ISO
eckol results in decreased expression of SOX2 protein
CTD
PMID:21514314
NCBI chr 2:121,165,137...121,167,545
Ensembl chr 2:121,165,137...121,167,545
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