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ONTOLOGY REPORT - ANNOTATIONS


Term:28,29-dihydroxyfriedelan-3-one
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Accession:CHEBI:65788 term browser browse the term
Definition:A pentacyclic triterpenoid that is friedelane substituted by hydroxy groups at positions 28 and 29 and an oxo group at position 3. Isolated from the stems of Maytenus diversifolia, it exhibits potent cytotoxicity against the A-549 lung carcinoma cells.
Synonyms:exact_synonym: (4R,4aS,6aS,6bR,8aR,11R,12aS,12bS,14aS,14bS)-8a,11-bis(hydroxymethyl)-4,4a,6b,11,12b,14a-hexamethylicosahydropicen-3(2H)-one
 related_synonym: 28,29-dihydroxy-D:A-friedooleanan-3-one;   Formula=C30H50O3;   InChI=1S/C30H50O3/c1-20-21(33)7-8-22-26(20,3)10-9-23-27(22,4)12-13-29(6)24-17-25(2,18-31)11-15-30(24,19-32)16-14-28(23,29)5/h20,22-24,31-32H,7-19H2,1-6H3/t20-,22+,23-,24-,25+,26+,27-,28+,29-,30+/m0/s1;   InChIKey=ZMSNKXDPESNSSS-CUKXIHTOSA-N;   SMILES=[H][C@@]12CCC(=O)[C@H](C)[C@@]1(C)CC[C@@]1([H])[C@@]2(C)CC[C@@]2(C)[C@]3([H])C[C@](C)(CO)CC[C@]3(CO)CC[C@]12C
 xref: Chemspider:10270945;   PMID:12713415;   PMID:2095372;   Reaxys:5139108


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Term Annotations click to browse term
  CHEBI ontology 24146
    role 24039
      biological role 24005
        biochemical role 23267
          metabolite 23169
            28,29-dihydroxyfriedelan-3-one 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 24146
    subatomic particle 24100
      composite particle 24100
        hadron 24100
          baryon 24100
            nucleon 24100
              atomic nucleus 24100
                atom 24100
                  main group element atom 23929
                    p-block element atom 23929
                      carbon group element atom 23662
                        carbon atom 23618
                          organic molecular entity 23618
                            organic group 22089
                              organic divalent group 22063
                                organodiyl group 22063
                                  carbonyl group 22038
                                    carbonyl compound 22038
                                      ketone 18150
                                        cyclic ketone 14548
                                          alicyclic ketone 1047
                                            cyclic terpene ketone 132
                                              28,29-dihydroxyfriedelan-3-one 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.