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ONTOLOGY REPORT - ANNOTATIONS


Term:28,29-dihydroxyfriedelan-3-one
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Accession:CHEBI:65788 term browser browse the term
Definition:A pentacyclic triterpenoid that is friedelane substituted by hydroxy groups at positions 28 and 29 and an oxo group at position 3. Isolated from the stems of Maytenus diversifolia, it exhibits potent cytotoxicity against the A-549 lung carcinoma cells.
Synonyms:exact_synonym: (4R,4aS,6aS,6bR,8aR,11R,12aS,12bS,14aS,14bS)-8a,11-bis(hydroxymethyl)-4,4a,6b,11,12b,14a-hexamethylicosahydropicen-3(2H)-one
 related_synonym: 28,29-dihydroxy-D:A-friedooleanan-3-one;   Formula=C30H50O3;   InChI=1S/C30H50O3/c1-20-21(33)7-8-22-26(20,3)10-9-23-27(22,4)12-13-29(6)24-17-25(2,18-31)11-15-30(24,19-32)16-14-28(23,29)5/h20,22-24,31-32H,7-19H2,1-6H3/t20-,22+,23-,24-,25+,26+,27-,28+,29-,30+/m0/s1;   InChIKey=ZMSNKXDPESNSSS-CUKXIHTOSA-N;   SMILES=[H][C@@]12CCC(=O)[C@H](C)[C@@]1(C)CC[C@@]1([H])[C@@]2(C)CC[C@@]2(C)[C@]3([H])C[C@](C)(CO)CC[C@]3(CO)CC[C@]12C
 xref: Chemspider:10270945;   PMID:12713415;   PMID:2095372;   Reaxys:5139108


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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.