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ONTOLOGY REPORT - ANNOTATIONS


Term:28,29-dihydroxyfriedelan-3-one
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Accession:CHEBI:65788 term browser browse the term
Definition:A pentacyclic triterpenoid that is friedelane substituted by hydroxy groups at positions 28 and 29 and an oxo group at position 3. Isolated from the stems of Maytenus diversifolia, it exhibits potent cytotoxicity against the A-549 lung carcinoma cells.
Synonyms:exact_synonym: (4R,4aS,6aS,6bR,8aR,11R,12aS,12bS,14aS,14bS)-8a,11-bis(hydroxymethyl)-4,4a,6b,11,12b,14a-hexamethylicosahydropicen-3(2H)-one
 related_synonym: 28,29-dihydroxy-D:A-friedooleanan-3-one;   Formula=C30H50O3;   InChI=1S/C30H50O3/c1-20-21(33)7-8-22-26(20,3)10-9-23-27(22,4)12-13-29(6)24-17-25(2,18-31)11-15-30(24,19-32)16-14-28(23,29)5/h20,22-24,31-32H,7-19H2,1-6H3/t20-,22+,23-,24-,25+,26+,27-,28+,29-,30+/m0/s1;   InChIKey=ZMSNKXDPESNSSS-CUKXIHTOSA-N;   SMILES=[H][C@@]12CCC(=O)[C@H](C)[C@@]1(C)CC[C@@]1([H])[C@@]2(C)CC[C@@]2(C)[C@]3([H])C[C@](C)(CO)CC[C@]3(CO)CC[C@]12C
 xref: Chemspider:10270945;   PMID:12713415;   PMID:2095372;   Reaxys:5139108


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Term Annotations click to browse term
  CHEBI ontology 19790
    role 19738
      biological role 19737
        biochemical role 19232
          metabolite 19208
            28,29-dihydroxyfriedelan-3-one 0
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Term Annotations click to browse term
  CHEBI ontology 19790
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19674
                    p-block element atom 19674
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18475
                              organic divalent group 18468
                                organodiyl group 18468
                                  carbonyl group 18366
                                    carbonyl compound 18366
                                      ketone 16011
                                        cyclic ketone 13487
                                          alicyclic ketone 1049
                                            cyclic terpene ketone 128
                                              28,29-dihydroxyfriedelan-3-one 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.