The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
A pentacyclic triterpenoid that is lupane in which the hydrogen at the 3beta position is substituted by a hydroxy group. It occurs in the skin of lupin seeds, as well as in the latex of fig trees and of rubber plants. It is also found in many edible fruits and vegetables.
Synonyms:
exact_synonym:
(3beta)-lup-20(29)-en-3-ol
related_synonym:
Formula=C30H50O; InChI=1S/C30H50O/c1-19(2)20-11-14-27(5)17-18-29(7)21(25(20)27)9-10-23-28(6)15-13-24(31)26(3,4)22(28)12-16-30(23,29)8/h20-25,31H,1,9-18H2,2-8H3/t20-,21+,22-,23+,24-,25+,27+,28-,29+,30+/m0/s1; InChIKey=MQYXUWHLBZFQQO-QGTGJCAVSA-N; SMILES=[H][C@]12CC[C@]3([H])[C@@]4(C)CC[C@H](O)C(C)(C)[C@]4([H])CC[C@@]3(C)[C@]1(C)CC[C@@]1(C)CC[C@@H](C(C)=C)[C@]21[H]; beta-viscol; fagarasterol; monogynol B
lupeol inhibits the reaction [mancozeb results in increased expression of BAX mRNA] lupeol results in increased expression of BAX mRNA; lupeol results in increased expression of BAX protein lupeol inhibits the reaction [COL2A1 results in decreased expression of BAX protein]
lupeol inhibits the reaction [mancozeb results in decreased expression of BCL2 mRNA] lupeol results in decreased expression of BCL2 mRNA; lupeol results in decreased expression of BCL2 protein lupeol inhibits the reaction [COL2A1 results in increased expression of BCL2 protein]
lupeol results in increased expression of CASP3 mRNA; lupeol results in increased expression of CASP3 protein lupeol inhibits the reaction [COL2A1 results in decreased expression of CASP3 protein]
lupeol results in increased expression of CASP9 mRNA; lupeol results in increased expression of CASP9 protein lupeol inhibits the reaction [COL2A1 results in decreased expression of CASP9 protein]
lupeol inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in decreased activity of CAT protein]; lupeol inhibits the reaction [Sodium Selenite results in decreased activity of CAT protein] lupeol inhibits the reaction [mancozeb results in decreased activity of CAT protein]
lupeol results in decreased activity of CFLAR protein enzalutamide promotes the reaction [lupeol results in decreased activity of CFLAR protein]; lupeol promotes the reaction [enzalutamide results in decreased activity of CFLAR protein]
lupeol inhibits the reaction [COL2A1 protein results in increased secretion of Dinoprostone]; lupeol inhibits the reaction [COL2A1 protein results in increased secretion of IL6 protein]; lupeol inhibits the reaction [COL2A1 protein results in increased secretion of TNF protein]; lupeol inhibits the reaction [COL2A1 results in decreased expression of BAX protein]; lupeol inhibits the reaction [COL2A1 results in decreased expression of CASP3 protein]; lupeol inhibits the reaction [COL2A1 results in decreased expression of CASP9 protein]; lupeol inhibits the reaction [COL2A1 results in increased activity of ALOX5 protein]; lupeol inhibits the reaction [COL2A1 results in increased activity of MPO protein]; lupeol inhibits the reaction [COL2A1 results in increased activity of PTGS2 protein]; lupeol inhibits the reaction [COL2A1 results in increased expression of AKT1 protein]; lupeol inhibits the reaction [COL2A1 results in increased expression of BCL2 protein]; lupeol inhibits the reaction [COL2A1 results in increased secretion of CP protein]; lupeol inhibits the reaction [COL2A1 results in increased secretion of CRP protein]
lupeol results in decreased expression of CTNNB1 protein lupeol results in decreased localization of and results in decreased activity of CTNNB1 protein
[lupeol binds to stearic acid] inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of MPO protein] lupeol inhibits the reaction [COL2A1 results in increased activity of MPO protein]
lupeol results in decreased expression of MYC mRNA enzalutamide promotes the reaction [lupeol results in decreased activity of MYC protein]; lupeol promotes the reaction [enzalutamide results in decreased activity of MYC protein]
lupeol results in increased expression of PTEN protein PTEN protein results in increased susceptibility to lupeol lupeol inhibits the reaction [[Butylhydroxybutylnitrosamine co-treated with Cacodylic Acid] results in decreased expression of PTEN protein]
lupeol inhibits the reaction [[Butylhydroxybutylnitrosamine co-treated with Cacodylic Acid] results in increased expression of PTGS2 protein]; lupeol inhibits the reaction [COL2A1 results in increased activity of PTGS2 protein]
lupeol inhibits the reaction [mancozeb affects the localization of RELA protein] lupeol inhibits the reaction [[Butylhydroxybutylnitrosamine co-treated with Cacodylic Acid] results in increased phosphorylation of RELA protein]
lupeol results in decreased expression of TNF mRNA lupeol inhibits the reaction [[Butylhydroxybutylnitrosamine co-treated with Cacodylic Acid] results in increased expression of TNF protein]; lupeol inhibits the reaction [COL2A1 protein results in increased secretion of TNF protein]
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