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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:corynoline
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Accession:CHEBI:65660 term browser browse the term
Definition:A benzophenanthridine alkaloid that is chelidonine substituted by a methyl group at position 13. Isolated from the aerial parts of Corydalis incisa, it acts as an acetylcholinesterase inhibitor and also exhibits antineoplastic and hepatoprotective activity.
Synonyms:exact_synonym: 13-methylchelidonine
 related_synonym: (11S,13R,14R)-corynoline;   (5bR,6S,12bR)-5b,13-dimethyl-5b,6,7,12b,13,14-hexahydro[1,3]benzodioxolo[5,6-c][1,3]dioxolo[4,5-i]phenanthridin-6-ol;   Formula=C21H21NO5;   InChI=1S/C21H21NO5/c1-21-14-3-4-15-19(27-10-24-15)13(14)8-22(2)20(21)12-7-17-16(25-9-26-17)5-11(12)6-18(21)23/h3-5,7,18,20,23H,6,8-10H2,1-2H3/t18-,20+,21-/m0/s1;   InChIKey=IQUGPRHKZNCHGC-TYPHKJRUSA-N;   SMILES=[H][C@]12N(C)Cc3c4OCOc4ccc3[C@@]1(C)[C@@H](O)Cc1cc3OCOc3cc21
 xref: CAS:18797-79-0
 xref_mesh: MESH:C487644
 xref: PMID:11156180;   PMID:11498866;   PMID:12510831;   PMID:15139147;   PMID:17366734;   PMID:20641061;   Reaxys:4275687



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corynoline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation ISO corynoline results in increased phosphorylation of GSK3B protein CTD PMID:34477289 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO corynoline promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMOX1 protein] CTD PMID:34477289 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO corynoline inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein] CTD PMID:34477289 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO corynoline inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of MPO protein] CTD PMID:34477289 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO corynoline promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NFE2L2 protein] CTD PMID:34477289 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO corynoline inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of NFKBIA protein] CTD PMID:34477289 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO corynoline inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RELA protein] CTD PMID:34477289 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO corynoline inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein] CTD PMID:34477289 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20069
    role 20021
      biological role 20020
        biochemical role 19656
          metabolite 19640
            corynoline 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 20069
    subatomic particle 20068
      composite particle 20068
        hadron 20068
          baryon 20068
            nucleon 20068
              atomic nucleus 20068
                atom 20068
                  main group element atom 19969
                    p-block element atom 19969
                      carbon group element atom 19892
                        carbon atom 19885
                          organic molecular entity 19885
                            organic molecule 19833
                              organic cyclic compound 19587
                                organic heterocyclic compound 18853
                                  organonitrogen heterocyclic compound 17949
                                    benzophenanthridine 127
                                      benzophenanthridine alkaloid 104
                                        chelidonine 18
                                          corynoline 8
paths to the root