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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:6550 term browser browse the term
Definition:A triazole that consists of 1,2,4-triazole bearing a methyl substituent at position 1, a hydroxymethyl substituent at position 3 and a {3-[3-(piperidin-1-ylmethyl)phenoxy]propyl}amino group at position 5. A highly potent and selective H2-receptor antagonist.
Synonyms:exact_synonym: [1-methyl-5-({3-[3-(piperidin-1-ylmethyl)phenoxy]propyl}amino)-1H-1,2,4-triazol-3-yl]methanol
 related_synonym: Formula=C19H29N5O2;   InChI=1S/C19H29N5O2/c1-23-19(21-18(15-25)22-23)20-9-6-12-26-17-8-5-7-16(13-17)14-24-10-3-2-4-11-24/h5,7-8,13,25H,2-4,6,9-12,14-15H2,1H3,(H,20,21,22);   InChIKey=VTLNPNNUIJHJQB-UHFFFAOYSA-N;   Lavoltidine;   Loxtidina;   Loxtidinum;   SMILES=Cn1nc(CO)nc1NCCCOc1cccc(CN2CCCCC2)c1;   lavoltidina;   lavoltidinum
 xref: CAS:76956-02-0;   KEGG:C11805
 xref_mesh: MESH:C039993
 xref: PMID:10219966;   PMID:11025361;   PMID:15940630;   PMID:1600050;   PMID:2038267;   PMID:2568467;   PMID:2883848;   PMID:2895888;   PMID:4041682;   PMID:6145595;   PMID:7605857;   PMID:8026255;   PMID:9131722;   Reaxys:6876968;   Wikipedia:Loxtidine

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loxtidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Areg amphiregulin multiple interactions
decreases expression
ISO [YF 476 co-treated with loxtidine] results in decreased expression of AREG mRNA
loxtidine results in decreased expression of AREG mRNA
CTD PMID:15940630 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535
JBrowse link
G Reg1a regenerating family member 1 alpha decreases expression
multiple interactions
ISO loxtidine results in decreased expression of REG1 mRNA
[YF 476 co-treated with loxtidine] results in decreased expression of REG1 mRNA
CTD PMID:15940630 NCBI chr 4:110,892,451...110,895,115
Ensembl chr 4:110,892,453...110,895,570
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      biological role 20011
        pharmacological role 19090
          antagonist 16737
            histamine antagonist 4861
              H2-receptor antagonist 211
                loxtidine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic molecule 19856
                              organic cyclic compound 19612
                                organic heterocyclic compound 18824
                                  heteroarene 16628
                                    monocyclic heteroarene 13606
                                      azole 12836
                                        triazoles 3700
                                          loxtidine 2
paths to the root