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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:6550 term browser browse the term
Definition:A triazole that consists of 1,2,4-triazole bearing a methyl substituent at position 1, a hydroxymethyl substituent at position 3 and a {3-[3-(piperidin-1-ylmethyl)phenoxy]propyl}amino group at position 5. A highly potent and selective H2-receptor antagonist.
Synonyms:exact_synonym: [1-methyl-5-({3-[3-(piperidin-1-ylmethyl)phenoxy]propyl}amino)-1H-1,2,4-triazol-3-yl]methanol
 related_synonym: Formula=C19H29N5O2;   InChI=1S/C19H29N5O2/c1-23-19(21-18(15-25)22-23)20-9-6-12-26-17-8-5-7-16(13-17)14-24-10-3-2-4-11-24/h5,7-8,13,25H,2-4,6,9-12,14-15H2,1H3,(H,20,21,22);   InChIKey=VTLNPNNUIJHJQB-UHFFFAOYSA-N;   Lavoltidine;   Loxtidina;   Loxtidinum;   SMILES=Cn1nc(CO)nc1NCCCOc1cccc(CN2CCCCC2)c1;   lavoltidina;   lavoltidinum
 xref: CAS:76956-02-0;   KEGG:C11805
 xref_mesh: MESH:C039993
 xref: PMID:10219966;   PMID:11025361;   PMID:15940630;   PMID:1600050;   PMID:2038267;   PMID:2568467;   PMID:2883848;   PMID:2895888;   PMID:4041682;   PMID:6145595;   PMID:7605857;   PMID:8026255;   PMID:9131722;   Reaxys:6876968;   Wikipedia:Loxtidine

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loxtidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Areg amphiregulin multiple interactions
decreases expression
ISO [YF 476 co-treated with loxtidine] results in decreased expression of AREG mRNA
loxtidine results in decreased expression of AREG mRNA
CTD PMID:15940630 NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179
JBrowse link
G Reg1a regenerating family member 1 alpha decreases expression
multiple interactions
ISO loxtidine results in decreased expression of REG1 mRNA
[YF 476 co-treated with loxtidine] results in decreased expression of REG1 mRNA
CTD PMID:15940630 NCBI chr 4:109,497,962...109,500,626
Ensembl chr 4:109,497,962...109,501,082
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        pharmacological role 18797
          antagonist 16197
            histamine antagonist 4603
              H2-receptor antagonist 210
                loxtidine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic heterocyclic compound 18410
                                  heteroarene 16447
                                    monocyclic heteroarene 13303
                                      azole 12471
                                        triazoles 3636
                                          loxtidine 2
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