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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:6550 term browser browse the term
Definition:A triazole that consists of 1,2,4-triazole bearing a methyl substituent at position 1, a hydroxymethyl substituent at position 3 and a {3-[3-(piperidin-1-ylmethyl)phenoxy]propyl}amino group at position 5. A highly potent and selective H2-receptor antagonist.
Synonyms:exact_synonym: [1-methyl-5-({3-[3-(piperidin-1-ylmethyl)phenoxy]propyl}amino)-1H-1,2,4-triazol-3-yl]methanol
 related_synonym: Formula=C19H29N5O2;   InChI=1S/C19H29N5O2/c1-23-19(21-18(15-25)22-23)20-9-6-12-26-17-8-5-7-16(13-17)14-24-10-3-2-4-11-24/h5,7-8,13,25H,2-4,6,9-12,14-15H2,1H3,(H,20,21,22);   InChIKey=VTLNPNNUIJHJQB-UHFFFAOYSA-N;   Lavoltidine;   Loxtidina;   Loxtidinum;   SMILES=Cn1nc(CO)nc1NCCCOc1cccc(CN2CCCCC2)c1;   lavoltidina;   lavoltidinum
 xref: CAS:76956-02-0;   KEGG:C11805
 xref_mesh: MESH:C039993
 xref: PMID:10219966;   PMID:11025361;   PMID:15940630;   PMID:1600050;   PMID:2038267;   PMID:2568467;   PMID:2883848;   PMID:2895888;   PMID:4041682;   PMID:6145595;   PMID:7605857;   PMID:8026255;   PMID:9131722;   Reaxys:6876968;   Wikipedia:Loxtidine

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loxtidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Areg amphiregulin multiple interactions
decreases expression
ISO [YF 476 co-treated with loxtidine] results in decreased expression of AREG mRNA
loxtidine results in decreased expression of AREG mRNA
CTD PMID:15940630 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535
JBrowse link
G Reg1a regenerating family member 1 alpha decreases expression
multiple interactions
ISO loxtidine results in decreased expression of REG1 mRNA
[YF 476 co-treated with loxtidine] results in decreased expression of REG1 mRNA
CTD PMID:15940630 NCBI chr 4:110,892,451...110,895,115
Ensembl chr 4:110,892,453...110,895,570
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        pharmacological role 18847
          antagonist 16277
            histamine antagonist 4616
              H2-receptor antagonist 211
                loxtidine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic molecule 19569
                              organic cyclic compound 19360
                                organic heterocyclic compound 18591
                                  heteroarene 16530
                                    monocyclic heteroarene 13437
                                      azole 12628
                                        triazoles 3664
                                          loxtidine 2
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