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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:bellidin
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Accession:CHEBI:65480 term browser browse the term
Definition:A member of the class of xanthones that is xanthone which is substituted by hydroxy groups at positions 1, 3, 5, and 8. A natural product found particularly in Iris nigricans and Gentiana campestris.
Synonyms:exact_synonym: 1,3,5,8-tetrahydroxy-9H-xanthen-9-one
 related_synonym: 1,3,5,8-Tetrahydroxyxanthone;   1,3,5,8-tetrahydroxyxanthen-9-one;   DMB;   Demethylbellidifolin;   Desmethylbellidifolin;   Formula=C13H8O6;   InChI=1S/C13H8O6/c14-5-3-8(17)10-9(4-5)19-13-7(16)2-1-6(15)11(13)12(10)18/h1-4,14-17H;   InChIKey=MPXAWSABMVLIBU-UHFFFAOYSA-N;   SMILES=Oc1cc(O)c2c(c1)oc1c(O)ccc(O)c1c2=O
 xref: CAS:2980-32-7;   KEGG:C10056;   KNApSAcK:C00002946;   PMID:1133711;   PMID:12221593;   PMID:14750034;   PMID:15234768;   PMID:15490334;   PMID:17127518;   PMID:19533580;   PMID:21675853;   PMID:3174858;   PMID:3889613;   PMID:4712626;   Reaxys:286545


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bellidifolin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAM17 ADAM metallopeptidase domain 17 multiple interactions ISO bellidifolin inhibits the reaction [Isoproterenol results in increased expression of ADAM17 mRNA] CTD PMID:37528096 NCBI chr 2:9,488,486...9,555,830
Ensembl chr 2:9,488,486...9,556,732 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions ISO bellidifolin inhibits the reaction [Hydrogen Peroxide results in increased expression of AKT1 mRNA]; bellidifolin inhibits the reaction [Hydrogen Peroxide results in increased expression of and results in increased phosphorylation of AKT1 protein] CTD PMID:36518482 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751 		JBrowse link
G BRD4 bromodomain containing 4 multiple interactions ISO bellidifolin inhibits the reaction [Isoproterenol results in increased expression of BRD4 mRNA]; bellidifolin inhibits the reaction [Isoproterenol results in increased expression of BRD4 protein] CTD PMID:37528096 NCBI chr19:15,235,519...15,332,539
Ensembl chr19:15,235,519...15,332,545 		JBrowse link
G CASP1 caspase 1 multiple interactions EXP bellidifolin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CASP1 protein] CTD PMID:37127800 NCBI chr11:105,025,443...105,036,686
Ensembl chr11:105,025,397...105,035,250 		JBrowse link
G CASP3 caspase 3 increases expression EXP bellidifolin results in increased expression of CASP3 protein CTD PMID:33299414 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP8 caspase 8 increases expression EXP bellidifolin results in increased expression of CASP8 protein CTD PMID:33299414 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836 		JBrowse link
G CEBPB CCAAT enhancer binding protein beta decreases expression EXP bellidifolin results in decreased expression of CEBPB mRNA CTD PMID:33299414 NCBI chr20:50,190,583...50,192,690
Ensembl chr20:50,190,830...50,192,668 		JBrowse link
G GCK glucokinase decreases activity ISO bellidifolin results in decreased activity of GCK protein CTD PMID:19962285 NCBI chr 7:44,143,213...44,189,439
Ensembl chr 7:44,143,213...44,198,170 		JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit increases expression ISO bellidifolin results in increased expression of GCLC mRNA; bellidifolin results in increased expression of GCLC protein CTD PMID:30800665 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970 		JBrowse link
G GSDMD gasdermin D multiple interactions EXP bellidifolin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] affects the localization of GSDMD protein alternative form]; bellidifolin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of GSDMD protein] CTD PMID:37127800 NCBI chr 8:143,553,387...143,563,062
Ensembl chr 8:143,553,207...143,563,062 		JBrowse link
G GSK3B glycogen synthase kinase 3 beta multiple interactions ISO bellidifolin inhibits the reaction [Hydrogen Peroxide results in increased expression of GSK3B mRNA]; bellidifolin inhibits the reaction [Hydrogen Peroxide results in increased expression of GSK3B protein] CTD PMID:36518482 NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994 		JBrowse link
G HMOX1 heme oxygenase 1 increases expression ISO bellidifolin results in increased expression of HMOX1 mRNA; bellidifolin results in increased expression of HMOX1 protein CTD PMID:30800665 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G IL18 interleukin 18 multiple interactions EXP bellidifolin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased secretion of IL18 protein] CTD PMID:37127800 NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,253...112,164,096 		JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP bellidifolin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased secretion of IL1B protein] CTD PMID:37127800 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G INSR insulin receptor increases expression ISO bellidifolin results in increased expression of INSR CTD PMID:19962285 NCBI chr19:7,112,265...7,294,414
Ensembl chr19:7,112,255...7,294,414 		JBrowse link
G IRS1 insulin receptor substrate 1 increases expression ISO bellidifolin results in increased expression of IRS1 CTD PMID:19962285 NCBI chr 2:226,731,312...226,799,820
Ensembl chr 2:226,731,312...226,799,820 		JBrowse link
G MYH7 myosin heavy chain 7 multiple interactions ISO bellidifolin inhibits the reaction [Isoproterenol results in increased expression of MYH7 protein] CTD PMID:37528096 NCBI chr14:23,412,740...23,435,660
Ensembl chr14:23,412,740...23,435,660 		JBrowse link
G NLRP3 NLR family pyrin domain containing 3 multiple interactions EXP bellidifolin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of NLRP3 protein] CTD PMID:37127800 NCBI chr 1:247,416,077...247,448,817
Ensembl chr 1:247,416,156...247,449,108 		JBrowse link
G NOX4 NADPH oxidase 4 multiple interactions ISO bellidifolin inhibits the reaction [Isoproterenol results in increased expression of NOX4 mRNA]; bellidifolin inhibits the reaction [Isoproterenol results in increased expression of NOX4 protein] CTD PMID:37528096 NCBI chr11:89,324,353...89,589,557
Ensembl chr11:89,324,353...89,498,187 		JBrowse link
G NPPA natriuretic peptide A multiple interactions ISO bellidifolin inhibits the reaction [Isoproterenol results in increased expression of NPPA protein] CTD PMID:37528096 NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345 		JBrowse link
G NPPB natriuretic peptide B multiple interactions ISO bellidifolin inhibits the reaction [Isoproterenol results in increased expression of NPPB protein] CTD PMID:37528096 NCBI chr 1:11,857,464...11,858,945
Ensembl chr 1:11,857,464...11,858,945 		JBrowse link
G NR4A1 nuclear receptor subfamily 4 group A member 1 multiple interactions ISO bellidifolin inhibits the reaction [TGFB1 protein results in increased phosphorylation of and affects the localization of NR4A1 protein] CTD PMID:33995055 NCBI chr12:52,022,832...52,059,503
Ensembl chr12:52,022,832...52,059,507 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 decreases expression EXP bellidifolin results in decreased expression of PARP1 protein CTD PMID:33299414 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154 		JBrowse link
G PTGER2 prostaglandin E receptor 2 decreases expression EXP bellidifolin results in decreased expression of PTGER2 mRNA CTD PMID:33299414 NCBI chr14:52,314,312...52,328,598
Ensembl chr14:52,314,305...52,328,598 		JBrowse link
G PTGER4 prostaglandin E receptor 4 decreases expression EXP bellidifolin results in decreased expression of PTGER4 mRNA CTD PMID:33299414 NCBI chr 5:40,679,915...40,746,800
Ensembl chr 5:40,679,915...40,693,735 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 decreases expression EXP bellidifolin results in decreased expression of PTGS2 protein CTD PMID:33299414 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G PYCARD PYD and CARD domain containing multiple interactions EXP bellidifolin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of PYCARD protein] CTD PMID:37127800 NCBI chr16:31,201,486...31,202,760
Ensembl chr16:31,201,486...31,203,450 		JBrowse link
G SMAD2 SMAD family member 2 multiple interactions ISO bellidifolin inhibits the reaction [TGFB1 protein results in increased expression of and results in increased phosphorylation of SMAD2 protein] CTD PMID:33995055 NCBI chr18:47,808,957...47,930,872
Ensembl chr18:47,808,957...47,931,146 		JBrowse link
G SMAD3 SMAD family member 3 multiple interactions ISO
EXP		 bellidifolin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:33995055 PMID:35586685 NCBI chr15:67,065,602...67,195,169
Ensembl chr15:67,063,763...67,195,173 		JBrowse link
G SMAD4 SMAD family member 4 multiple interactions ISO bellidifolin inhibits the reaction [TGFB1 protein results in increased expression of SMAD4 protein] CTD PMID:33995055 NCBI chr18:51,030,213...51,085,042
Ensembl chr18:51,028,528...51,085,045 		JBrowse link
G SOX9 SRY-box transcription factor 9 multiple interactions ISO
EXP		 bellidifolin inhibits the reaction [Isoproterenol results in increased expression of SOX9 protein]
bellidifolin inhibits the reaction [TGFB1 protein results in increased expression of SOX9 protein]		 CTD PMID:35586685 NCBI chr17:72,121,020...72,126,416
Ensembl chr17:72,121,020...72,126,416 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 decreases expression
multiple interactions		 EXP bellidifolin results in decreased expression of STAT3 mRNA
bellidifolin results in decreased expression of and results in decreased phosphorylation of STAT3 protein		 CTD PMID:33299414 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568 		JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions EXP
ISO		 bellidifolin inhibits the reaction [TGFB1 protein results in increased expression of SOX9 protein]; bellidifolin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]
bellidifolin inhibits the reaction [TGFB1 protein results in increased expression of and results in increased phosphorylation of SMAD2 protein]; bellidifolin inhibits the reaction [TGFB1 protein results in increased expression of and results in increased phosphorylation of TGFBR1 protein]; bellidifolin inhibits the reaction [TGFB1 protein results in increased expression of and results in increased phosphorylation of TGFBR2 protein]; bellidifolin inhibits the reaction [TGFB1 protein results in increased expression of SMAD4 protein]; bellidifolin inhibits the reaction [TGFB1 protein results in increased phosphorylation of and affects the localization of NR4A1 protein]; bellidifolin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]
bellidifolin inhibits the reaction [TGFB1 protein results in increased expression of SMAD4 protein]; bellidifolin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]		 CTD PMID:33995055 PMID:35586685 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TGFBR1 transforming growth factor beta receptor 1 multiple interactions ISO bellidifolin inhibits the reaction [TGFB1 protein results in increased expression of and results in increased phosphorylation of TGFBR1 protein] CTD PMID:33995055 NCBI chr 9:99,103,647...99,154,192
Ensembl chr 9:99,104,038...99,154,192 		JBrowse link
G TGFBR2 transforming growth factor beta receptor 2 multiple interactions ISO bellidifolin inhibits the reaction [TGFB1 protein results in increased expression of and results in increased phosphorylation of TGFBR2 protein] CTD PMID:33995055 NCBI chr 3:30,606,356...30,694,142
Ensembl chr 3:30,606,601...30,694,142 		JBrowse link
G TNF tumor necrosis factor multiple interactions ISO bellidifolin inhibits the reaction [Isoproterenol results in increased expression of TNF mRNA] CTD PMID:37528096 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
norswertianolin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GCLC glutamate-cysteine ligase catalytic subunit increases expression ISO norswertianolin results in increased expression of GCLC mRNA; norswertianolin results in increased expression of GCLC protein CTD PMID:30800665 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970 		JBrowse link
G HMOX1 heme oxygenase 1 increases expression ISO norswertianolin results in increased expression of HMOX1 mRNA; norswertianolin results in increased expression of HMOX1 protein CTD PMID:30800665 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26034
    role 25961
      chemical role 24242
        antioxidant 17487
          bellidin 36
            bellidifolin + 36
            norswertianolin 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    p-block element atom 25834
                      carbon group element atom 25434
                        carbon atom 25403
                          organic molecular entity 25392
                            organic molecule 25222
                              organic cyclic compound 24274
                                organic heterocyclic compound 22328
                                  oxacycle 19986
                                    dibenzopyran 288
                                      xanthenes 282
                                        xanthones 212
                                          xanthone 187
                                            bellidin 36
                                              bellidifolin + 36
                                              norswertianolin 2
paths to the root