The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
An enone that is cyclohex-2-en-1-one substituted by a hydroxy group at position 4, methoxy groups at positions 2 and 3, a methyl group at position 6 and a (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl group at position 5 (the 4R,5R,6R stereoisomer). It is isolated from the solid-state fermented mycelium of the fungus Antrodia camphorata and has been found to exhibit potent cytotoxicity against a number of human cancer cell lines. However, a synthesis-enabled biological re-examination published in 2016, revealed minimal in vitro and in vivo antitumour activity in preclinical models.
antroquinonol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUN protein] antroquinonol results in decreased expression of JUN protein
antroquinonol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein] antroquinonol results in decreased phosphorylation of MAPK1 protein
antroquinonol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein] antroquinonol results in decreased phosphorylation of MAPK3 protein
antroquinonol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]; antroquinonol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein]
antroquinonol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RELA protein] antroquinonol results in decreased phosphorylation of RELA protein
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