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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:andrographolide
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Accession:CHEBI:65408 term browser browse the term
Definition:A labdane diterpenoid isolated from the leaves and roots of Andrographis paniculata that exhibits anti-HIV, anti-inflammatory and antineoplastic properties.
Synonyms:exact_synonym: (3E,4S)-4-hydroxy-3-{2-[(1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidenedecahydronaphthalen-1-yl]ethylidene}dihydrofuran-2(3H)-one
 related_synonym: (1R-(1-alpha(E(S)),4abeta,5alpha,6alpha,8aalpha))-3-(2-(decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl)ethylidene)dihydro-4-hydroxy-2(3H)-furanone;   3-(2-(decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenenaphthyl)ethylidene)dihydro-4-hydroxyfuran-2(3H)-one;   3alpha,14,15,18-tetrahydroxy-5b,9bH,10a-labda-8(20),12-dien-16-oic acid gamma-Lactone;   Formula=C20H30O5;   InChI=1S/C20H30O5/c1-12-4-7-16-19(2,9-8-17(23)20(16,3)11-21)14(12)6-5-13-15(22)10-25-18(13)24/h5,14-17,21-23H,1,4,6-11H2,2-3H3/b13-5+/t14-,15-,16+,17-,19+,20+/m1/s1;   InChIKey=BOJKULTULYSRAS-OTESTREVSA-N;   SMILES=[H][C@]12CCC(=C)[C@@H](C\\C=C3/[C@H](O)COC3=O)[C@]1(C)CC[C@@H](O)[C@@]2(C)CO
 xref: CAS:5508-58-7;   KEGG:C20214
 xref_mesh: MESH:C030419
 xref: PMID:15894448;   PMID:18464090;   PMID:19110075;   PMID:22026410;   PMID:22512591;   PMID:22858223;   Patent:CN102397273;   Patent:EP2411004;   Reaxys:5609598;   Wikipedia:Andrographolide


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andrographolide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of ABCC4 mRNA CTD PMID:19737545 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression
multiple interactions
EXP
ISO
andrographolide results in decreased expression of ACTA2 mRNA; andrographolide results in decreased expression of ACTA2 protein
andrographolide inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]
andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of ACTA2 mRNA]; andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of ACTA2 protein]; andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of ACTA2 protein]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of ACTA2 protein]]
andrographolide inhibits the reaction [Acetaminophen results in increased expression of ACTA2 mRNA]; andrographolide inhibits the reaction [Acetaminophen results in increased expression of ACTA2 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of ACTA2 protein]; NFE2L2 gene mutant form inhibits the reaction [andrographolide inhibits the reaction [Acetaminophen results in increased expression of ACTA2 protein]]
CTD PMID:29355602, PMID:31128153, PMID:31706003 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of ADH7 mRNA CTD PMID:19737545 NCBI chr 2:243,500,540...243,516,865
Ensembl chr 2:243,502,073...243,516,532
JBrowse link
G Ankrd1 ankyrin repeat domain 1 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of ANKRD1 mRNA CTD PMID:19737545 NCBI chr 1:254,726,985...254,745,673
Ensembl chr 1:254,726,969...254,735,548
JBrowse link
G Atf2 activating transcription factor 2 multiple interactions ISO andrographolide inhibits the reaction [cobaltous chloride results in increased expression of ATF2 protein modified form]; DUSP10 protein promotes the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of ATF2 protein modified form]] CTD PMID:29165873 NCBI chr 3:60,721,137...60,795,951
Ensembl chr 3:60,721,135...60,795,951
JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects folding
increases expression
multiple interactions
ISO andrographolide affects the folding of BAX protein
andrographolide results in increased expression of BAX mRNA; andrographolide results in increased expression of BAX protein
[andrographolide co-treated with Cisplatin] results in increased expression of BAX mRNA; andrographolide promotes the reaction [Cisplatin results in increased expression of BAX protein]; Fluorouracil promotes the reaction [andrographolide affects the folding of BAX protein]
CTD PMID:19097688, PMID:23845849, PMID:24563380 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO andrographolide results in decreased expression of BCL2 protein
[andrographolide co-treated with Cisplatin] results in decreased expression of BCL2 mRNA
CTD PMID:23845849, PMID:24563380 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bhmt betaine-homocysteine S-methyltransferase multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of BHMT mRNA CTD PMID:19737545 NCBI chr 2:23,236,573...23,256,158
Ensembl chr 2:23,236,575...23,256,158
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
increases expression
EXP
ISO
andrographolide inhibits the reaction [Copper Sulfate results in decreased expression of and results in increased cleavage of BID protein]; andrographolide promotes the reaction [Penicillamine inhibits the reaction [Copper Sulfate results in decreased expression of and results in increased cleavage of BID protein]]; Penicillamine promotes the reaction [andrographolide inhibits the reaction [Copper Sulfate results in decreased expression of and results in increased cleavage of BID protein]]
[andrographolide co-treated with Cisplatin] results in increased expression of BID mRNA
andrographolide results in increased expression of BID mRNA; andrographolide results in increased expression of BID protein
CTD PMID:20946909, PMID:24563380 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO andrographolide results in decreased expression of BIRC5 protein CTD PMID:23845849 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Blvrb biliverdin reductase B multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of BLVRB mRNA CTD PMID:19737545 NCBI chr 1:84,256,063...84,273,726
Ensembl chr 1:84,256,159...84,274,075
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases expression
ISO
EXP
andrographolide results in increased activity of CASP3 protein
andrographolide inhibits the reaction [TGFB1 protein results in decreased cleavage of CASP3 protein]
andrographolide results in increased expression of CASP3 mRNA
[andrographolide co-treated with Cisplatin] results in increased expression of CASP3 mRNA; CASP8 affects the reaction [Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP3 protein]]; Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP3 protein]
andrographolide inhibits the reaction [Copper Sulfate results in increased cleavage of CASP3 protein]; andrographolide promotes the reaction [Penicillamine inhibits the reaction [Copper Sulfate results in increased cleavage of CASP3 protein]]; Penicillamine promotes the reaction [andrographolide inhibits the reaction [Copper Sulfate results in increased cleavage of CASP3 protein]]
CTD PMID:19097688, PMID:20946909, PMID:24563380, PMID:31706003 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases activity
increases expression
multiple interactions
ISO
EXP
andrographolide results in increased activity of CASP8 protein
andrographolide results in increased expression of CASP8 mRNA
[andrographolide co-treated with Cisplatin] results in increased expression of CASP8 mRNA; CASP8 affects the reaction [Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP3 protein]]; CASP8 affects the reaction [Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP9 protein]]; CASP8 results in increased susceptibility to [andrographolide co-treated with Fluorouracil]; Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP8 protein]
andrographolide inhibits the reaction [Copper Sulfate results in increased activity of CASP8 protein]
CTD PMID:19097688, PMID:20946909, PMID:24563380 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases activity
increases expression
multiple interactions
ISO
EXP
andrographolide results in increased activity of CASP9 protein
andrographolide results in increased expression of CASP9 mRNA
andrographolide inhibits the reaction [Copper Sulfate results in increased activity of CASP9 protein]; andrographolide promotes the reaction [Penicillamine inhibits the reaction [Copper Sulfate results in increased activity of CASP9 protein]]; Penicillamine promotes the reaction [andrographolide inhibits the reaction [Copper Sulfate results in increased activity of CASP9 protein]]
[andrographolide co-treated with Cisplatin] results in increased expression of CASP9 mRNA; CASP8 affects the reaction [Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP9 protein]]; Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP9 protein]
CTD PMID:19097688, PMID:20946909, PMID:24563380 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions ISO
EXP
[andrographolide co-treated with Polylactic Acid-Polyglycolic Acid Copolymer] inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; andrographolide inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]
andrographolide inhibits the reaction [Freund's Adjuvant results in decreased activity of CAT protein]
CTD PMID:26485141, PMID:32061742 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cbr1 carbonyl reductase 1 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of CBR1 mRNA CTD PMID:19737545 NCBI chr11:33,813,041...33,815,418
Ensembl chr11:33,845,463...33,847,793
JBrowse link
G Cbr3 carbonyl reductase 3 multiple interactions
increases expression
ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of CBR3 mRNA
andrographolide results in increased expression of CBR3 mRNA
CTD PMID:19737545 NCBI chr11:33,909,417...33,917,674
Ensembl chr11:33,909,439...33,917,674
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CCL2 mRNA CTD PMID:19737545 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CCN2 mRNA CTD PMID:19737545 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Ccna2 cyclin A2 multiple interactions
decreases expression
ISO andrographolide inhibits the reaction [CCNA2 protein binds to CDK2 protein]
andrographolide results in decreased expression of CCNA2 protein
CTD PMID:18619950 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO andrographolide inhibits the reaction [CCND1 protein binds to CDK4 protein]
andrographolide results in decreased expression of CCND1 protein
CTD PMID:18619950, PMID:23845849 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccne1 cyclin E1 decreases expression
multiple interactions
ISO andrographolide results in decreased expression of CCNE1 protein
andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCNE1 protein]
CTD PMID:23845849, PMID:27475717 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO andrographolide inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 protein]
andrographolide inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 protein]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 protein]]
CTD PMID:31128153 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdh17 cadherin 17 decreases expression
multiple interactions
ISO andrographolide results in decreased expression of CDH17 mRNA
[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CDH17 mRNA
CTD PMID:19737545 NCBI chr 5:25,354,187...25,443,675
Ensembl chr 5:25,391,115...25,443,718
JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 protein]
andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 protein]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 protein]]
CTD PMID:31128153 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression
multiple interactions
ISO andrographolide results in decreased expression of CDK2 protein
andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CDK2 protein]
andrographolide inhibits the reaction [CCNA2 protein binds to CDK2 protein]
CTD PMID:18619950, PMID:27475717 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions
decreases expression
ISO andrographolide inhibits the reaction [CCND1 protein binds to CDK4 protein]
andrographolide results in decreased expression of CDK4 protein
CTD PMID:18619950 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO andrographolide results in increased expression of CDKN1A protein CTD PMID:18619950, PMID:23845849 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO andrographolide affects the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] affects the expression of CEBPA mRNA]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CEBPA protein] CTD PMID:27475717 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions ISO andrographolide affects the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] affects the expression of CEBPB mRNA]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of and results in increased phosphorylation of CEBPB protein] CTD PMID:27475717 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Ces3a carboxylesterase 3a multiple interactions
increases expression
ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of CES3 mRNA
andrographolide results in increased expression of CES3 mRNA
CTD PMID:19737545 NCBI chr19:37,070,705...37,079,411 JBrowse link
G Cish cytokine inducible SH2-containing protein multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CISH mRNA CTD PMID:19737545 NCBI chr 8:116,054,547...116,059,494
Ensembl chr 8:116,054,465...116,060,723
JBrowse link
G Cnn2 calponin 2 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CNN2 mRNA CTD PMID:19737545 NCBI chr 7:12,782,459...12,787,977
Ensembl chr 7:12,782,491...12,787,750
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
decreases expression
ISO
EXP
andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of COL1A1 mRNA]
andrographolide inhibits the reaction [Acetaminophen results in increased expression of COL1A1 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]
andrographolide results in decreased expression of COL1A1 mRNA
CTD PMID:29355602, PMID:31706003 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col1a2 collagen type I alpha 2 chain decreases expression
multiple interactions
ISO
EXP
andrographolide results in decreased expression of COL1A2 mRNA
andrographolide inhibits the reaction [Acetaminophen results in increased expression of COL1A2 mRNA]
CTD PMID:29355602 NCBI chr 4:31,534,225...31,569,152
Ensembl chr 4:31,534,225...31,569,151
JBrowse link
G Col3a1 collagen type III alpha 1 chain decreases expression
multiple interactions
EXP
ISO
andrographolide results in decreased expression of COL3A1 mRNA
andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of COL3A1 mRNA]
andrographolide inhibits the reaction [Acetaminophen results in increased expression of COL3A1 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 protein]
CTD PMID:29355602, PMID:31706003 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Crct1 cysteine-rich C-terminal 1 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CRCT1 mRNA CTD PMID:19737545 Ensembl chr 2:193,330,397...193,330,699 JBrowse link
G Cxcl13 C-X-C motif chemokine ligand 13 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CXCL13 mRNA CTD PMID:19737545 NCBI chr14:15,253,146...15,258,221
Ensembl chr14:15,253,125...15,258,207
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions EXP andrographolide inhibits the reaction [Freund's Adjuvant results in increased expression of CXCL2 protein] CTD PMID:32061742 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CYP17A1 mRNA CTD PMID:19737545 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
increases activity
ISO [andrographolide co-treated with benz(a)anthracene] results in increased expression of CYP1A1 mRNA; [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of CYP1A1 mRNA; [andrographolide co-treated with Tetrachlorodibenzodioxin] results in increased expression of CYP1A1 mRNA; Acetylcysteine affects the reaction [andrographolide affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]]; andrographolide affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; andrographolide promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Ascorbic Acid affects the reaction [andrographolide affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]]; beta-Naphthoflavone promotes the reaction [andrographolide results in increased expression of CYP1A1 mRNA]; Buthionine Sulfoximine promotes the reaction [andrographolide affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]]; Glutathione affects the reaction [andrographolide affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]]; Hydrogen Peroxide promotes the reaction [andrographolide affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]]; resveratrol inhibits the reaction [[andrographolide co-treated with benz(a)anthracene] results in increased expression of CYP1A1 mRNA]
andrographolide results in increased activity of CYP1A1 protein
CTD PMID:17825862, PMID:19737545, PMID:21094198, PMID:21963808 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases expression
multiple interactions
increases expression
ISO
EXP
andrographolide results in decreased expression of CYP1A2 mRNA
andrographolide affects the reaction [CYP1A2 protein results in increased metabolism of Theophylline]
andrographolide results in increased expression of CYP1A2 mRNA
[andrographolide co-treated with benz(a)anthracene] results in increased expression of CYP1A2 mRNA; [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of CYP1A2 mRNA
CTD PMID:17825862, PMID:19041297, PMID:19737545, PMID:20096675 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO [andrographolide co-treated with benz(a)anthracene] results in increased expression of CYP1B1 mRNA; andrographolide promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1B1 mRNA] CTD PMID:17825862, PMID:19737545 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases activity
increases expression
multiple interactions
ISO andrographolide results in increased activity of CYP2B10 protein
andrographolide results in increased expression of CYP2B10 mRNA
[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of CYP2B10 mRNA
CTD PMID:19737545, PMID:21094198 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases expression
ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of CYP2B9 mRNA
andrographolide results in increased expression of CYP2B9 mRNA
CTD PMID:19737545 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases expression EXP andrographolide results in decreased expression of CYP2C11 mRNA; andrographolide results in decreased expression of CYP2C11 protein CTD PMID:19041297 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 decreases expression EXP andrographolide results in decreased expression of CYP3A23-3A1 mRNA CTD PMID:19041297 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 increases expression ISO andrographolide results in increased expression of CYP8B1 mRNA CTD PMID:19737545 NCBI chr 8:130,548,418...130,550,388
Ensembl chr 8:130,548,418...130,550,388
JBrowse link
G Ddc dopa decarboxylase multiple interactions
increases expression
ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of DDC mRNA
andrographolide results in increased expression of DDC mRNA
CTD PMID:19737545 NCBI chr14:91,905,919...91,996,816
Ensembl chr14:91,905,919...91,996,774
JBrowse link
G Dusp10 dual specificity phosphatase 10 increases expression
multiple interactions
ISO andrographolide results in increased expression of DUSP10 mRNA; andrographolide results in increased expression of DUSP10 protein
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [andrographolide results in increased expression of DUSP10 mRNA]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [andrographolide results in increased expression of DUSP10 protein]; DUSP10 protein promotes the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of ATF2 protein modified form]]; DUSP10 protein promotes the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]]; HMOX1 protein promotes the reaction [andrographolide results in increased expression of DUSP10 protein]; zinc protoporphyrin inhibits the reaction [andrographolide results in increased expression of DUSP10 mRNA]; zinc protoporphyrin inhibits the reaction [andrographolide results in increased expression of DUSP10 protein]
CTD PMID:29165873 NCBI chr13:104,284,660...104,321,455
Ensembl chr13:104,284,660...104,321,455
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO andrographolide inhibits the reaction [cobaltous chloride results in increased expression of EDN1 mRNA]; andrographolide inhibits the reaction [cobaltous chloride results in increased expression of EDN1 protein]; Vanadates inhibits the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of EDN1 mRNA]]; Vanadates inhibits the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of EDN1 protein]] CTD PMID:27297870, PMID:29165873 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 multiple interactions
increases expression
ISO EGLN1 mutant form inhibits the reaction [andrographolide results in decreased expression of HIF1A protein]; EGLN1 mutant form inhibits the reaction [andrographolide results in decreased expression of VEGFA protein]; TGFB1 protein inhibits the reaction [andrographolide results in increased expression of EGLN1 mRNA]; TGFB1 protein inhibits the reaction [andrographolide results in increased expression of EGLN1 protein]
andrographolide results in increased expression of EGLN1 mRNA; andrographolide results in increased expression of EGLN1 protein
CTD PMID:21134392, PMID:27297870 NCBI chr19:57,660,194...57,701,158
Ensembl chr19:57,662,278...57,699,113
JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 increases expression ISO andrographolide results in increased expression of EGLN3 protein CTD PMID:27297870 NCBI chr 6:75,050,329...75,075,795
Ensembl chr 6:75,050,329...75,075,795
JBrowse link
G Eid3 EP300 interacting inhibitor of differentiation 3 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of EID3 mRNA CTD PMID:19737545 NCBI chr 7:26,976,154...26,977,479 JBrowse link
G Elane elastase, neutrophil expressed multiple interactions EXP andrographolide inhibits the reaction [Freund's Adjuvant results in increased expression of ELANE protein] CTD PMID:32061742 NCBI chr 7:12,638,320...12,640,168
Ensembl chr 7:12,638,322...12,640,232
JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit multiple interactions ISO andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of EZH2 protein]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of EZH2 protein]] CTD PMID:31128153 NCBI chr 4:77,284,404...77,347,011
Ensembl chr 4:77,284,404...77,347,011
JBrowse link
G Fas Fas cell surface death receptor multiple interactions
increases expression
ISO [andrographolide co-treated with Cisplatin] promotes the reaction [FAS protein binds to FASLG protein]; [andrographolide co-treated with Cisplatin] results in increased expression of FAS mRNA; [andrographolide co-treated with Cisplatin] results in increased expression of FAS protein; andrographolide promotes the reaction [FAS protein binds to FASLG protein]
andrographolide results in increased expression of FAS mRNA; andrographolide results in increased expression of FAS protein
CTD PMID:24563380 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand multiple interactions
increases expression
ISO [andrographolide co-treated with Cisplatin] promotes the reaction [FAS protein binds to FASLG protein]; [andrographolide co-treated with Cisplatin] results in increased expression of FASLG mRNA; [andrographolide co-treated with Cisplatin] results in increased expression of FASLG protein; andrographolide promotes the reaction [FAS protein binds to FASLG protein]
andrographolide results in increased expression of FASLG mRNA; andrographolide results in increased expression of FASLG protein
CTD PMID:24563380 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of FASN mRNA]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of FASN protein] CTD PMID:27475717 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 decreases expression ISO andrographolide results in decreased expression of FLT1 mRNA CTD PMID:28651835 NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO andrographolide inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein] CTD PMID:31706003 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO andrographolide results in decreased localization of and results in decreased activity of FOS protein CTD PMID:19426720 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
EXP
ISO
andrographolide results in increased expression of GCLC mRNA; andrographolide results in increased expression of GCLC protein
andrographolide inhibits the reaction [Acetaminophen results in decreased expression of GCLC mRNA]
CTD PMID:25110055, PMID:29355602 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions
increases expression
ISO
EXP
[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of GCLM mRNA; andrographolide inhibits the reaction [Acetaminophen results in decreased expression of GCLM mRNA]
andrographolide results in increased expression of GCLM protein
andrographolide results in increased expression of GCLM mRNA; andrographolide results in increased expression of GCLM protein
CTD PMID:19737545, PMID:25110055, PMID:29355602 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO [polylactic acid-polyglycolic acid copolymer co-treated with andrographolide] inhibits the reaction [sodium arsenite results in increased activity of GPT protein] CTD PMID:26485141 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of GSK3B protein] CTD PMID:27475717 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gsr glutathione-disulfide reductase increases activity EXP andrographolide results in increased activity of GSR protein CTD PMID:25110055 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gstm2 glutathione S-transferase mu 2 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of GSTM2 mRNA CTD PMID:19737545 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Gstm4 glutathione S-transferase mu 4 increases expression
multiple interactions
ISO andrographolide results in increased expression of GSTM4 mRNA
[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of GSTM4 mRNA
CTD PMID:19737545 NCBI chr 2:210,834,013...210,839,242
Ensembl chr 2:210,833,884...210,839,295
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 increases expression
multiple interactions
ISO andrographolide results in increased expression of GSTM3 mRNA
[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of GSTM3 mRNA
CTD PMID:19737545 NCBI chr 2:210,685,338...210,688,133
Ensembl chr 2:210,685,197...210,688,272
JBrowse link
G Hdac1 histone deacetylase 1 decreases expression ISO andrographolide results in decreased expression of HDAC1 protein CTD PMID:28651835 NCBI chr 5:147,716,664...147,743,723
Ensembl chr 5:147,716,664...147,743,723
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
decreases expression
increases expression
ISO [andrographolide co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased ubiquitination of HIF1A protein; [andrographolide co-treated with cobaltous chloride] results in increased hydroxylation of HIF1A protein; andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]; andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; andrographolide inhibits the reaction [HIF1A protein binds to VEGFA promoter]; andrographolide results in decreased expression of and affects the localization of HIF1A protein; andrographolide results in decreased expression of and results in increased degradation of HIF1A protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [andrographolide results in decreased expression of HIF1A protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [andrographolide results in increased degradation of HIF1A protein]; DUSP10 protein promotes the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]]; EGLN1 mutant form inhibits the reaction [andrographolide results in decreased expression of HIF1A protein]; HMOX1 protein affects the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]]; NFE2L2 protein affects the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]]; pyrazolanthrone inhibits the reaction [andrographolide results in decreased expression of HIF1A protein]; Vanadates inhibits the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]]; Vanadates inhibits the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]]
andrographolide results in increased expression of HIF1A protein modified form
CTD PMID:21134392, PMID:27297870, PMID:28651835, PMID:29165873 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
EXP
ISO
andrographolide results in increased expression of HMOX1 mRNA; andrographolide results in increased expression of HMOX1 protein
andrographolide inhibits the reaction [Acetaminophen results in decreased expression of HMOX1 mRNA]
HMOX1 protein affects the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]]; HMOX1 protein promotes the reaction [andrographolide results in increased expression of DUSP10 protein]
CTD PMID:25110055, PMID:27297870, PMID:29165873, PMID:29355602 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hp haptoglobin multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of HP mRNA CTD PMID:19737545 NCBI chr19:42,096,255...42,100,805
Ensembl chr19:42,097,995...42,100,804
JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of HPGD mRNA CTD PMID:19737545 NCBI chr16:37,457,134...37,495,758
Ensembl chr16:37,457,135...37,495,758
JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of IKBKE mRNA CTD PMID:19737545 NCBI chr13:48,031,325...48,056,394
Ensembl chr13:48,031,410...48,056,394
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of IL6 protein]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 protein]]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of ACTA2 protein]]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 protein]]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of EZH2 protein]]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of HOTAIR mRNA]]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of VIM protein]]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of STAT3 protein]]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of IL6 protein]]
andrographolide inhibits the reaction [Freund's Adjuvant results in increased expression of IL6 protein]
andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of IL6 mRNA]; andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of IL6 protein]
CTD PMID:31128153, PMID:32061742 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO andrographolide results in decreased localization of and results in decreased activity of JUN protein CTD PMID:19426720 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kdr kinase insert domain receptor multiple interactions
decreases expression
ISO [andrographolide co-treated with KDR protein] inhibits the reaction [VEGFA protein binds to KDR protein]; andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein]
andrographolide results in decreased expression of KDR mRNA
CTD PMID:24814888, PMID:28651835 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 decreases expression ISO andrographolide results in decreased expression of KEAP1 protein CTD PMID:29355602 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G LOC102551453 keratin, type II cytoskeletal 5-like multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of KRT5 mRNA CTD PMID:19737545 NCBI chr 7:143,290,296...143,317,563
Ensembl chr 7:143,312,546...143,317,707
JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 multiple interactions ISO andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAP2K4 protein] CTD PMID:24814888 NCBI chr10:52,196,121...52,301,887
Ensembl chr10:52,196,124...52,290,657
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 multiple interactions ISO andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAP2K6 protein] CTD PMID:24814888 NCBI chr10:98,707,160...98,823,054
Ensembl chr10:98,706,960...98,823,287
JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 multiple interactions ISO andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAP2K7 protein] CTD PMID:24814888 NCBI chr12:2,546,278...2,555,310
Ensembl chr12:2,548,218...2,555,164
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 multiple interactions ISO andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAP3K5 protein] CTD PMID:24814888 NCBI chr 1:15,412,603...15,613,752
Ensembl chr 1:15,412,603...15,613,746
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK1 protein]
andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of MAPK1 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]
CTD PMID:24814888, PMID:27475717, PMID:31706003 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK3 protein]
andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of MAPK3 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein]
CTD PMID:24814888, PMID:27475717, PMID:31706003 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO andrographolide inhibits the reaction [TGFB1 protein results in increased expression of MMP2 mRNA] CTD PMID:31706003 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp7 matrix metallopeptidase 7 decreases expression
multiple interactions
ISO andrographolide results in decreased expression of MMP7 mRNA
andrographolide results in decreased expression of and results in decreased activity of MMP7 protein
CTD PMID:19426720 NCBI chr 8:5,893,253...5,900,965
Ensembl chr 8:5,893,249...5,901,049
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO andrographolide inhibits the reaction [TGFB1 protein results in increased expression of MMP9 mRNA] CTD PMID:31706003 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP andrographolide inhibits the reaction [Freund's Adjuvant results in increased expression of MPO protein] CTD PMID:32061742 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mta1 metastasis associated 1 decreases expression ISO andrographolide results in decreased expression of MTA1 mRNA; andrographolide results in decreased expression of MTA1 protein CTD PMID:28651835 NCBI chr 6:137,911,302...137,950,066
Ensembl chr 6:137,924,293...137,950,075
JBrowse link
G Myo18b myosin XVIIIb decreases expression ISO andrographolide results in decreased expression of MYO18B mRNA CTD PMID:19737545 NCBI chr12:49,761,100...49,979,745
Ensembl chr12:49,761,120...49,979,758
JBrowse link
G Necab1 N-terminal EF-hand calcium binding protein 1 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of NECAB1 mRNA CTD PMID:19737545 NCBI chr 5:28,507,596...28,737,556
Ensembl chr 5:28,504,558...28,737,719
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases activity
decreases response to substance
multiple interactions
EXP
ISO
andrographolide results in increased activity of NFE2L2 protein
NFE2L2 gene mutant form results in decreased susceptibility to andrographolide
NFE2L2 gene mutant form inhibits the reaction [andrographolide inhibits the reaction [Acetaminophen results in increased expression of ACTA2 protein]]
NFE2L2 protein affects the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]]
CTD PMID:25110055, PMID:27297870, PMID:29355602 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Ngb neuroglobin multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of NGB mRNA CTD PMID:19737545 NCBI chr 6:111,126,259...111,131,699
Ensembl chr 6:111,126,261...111,132,320
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
ISO
EXP
andrographolide results in increased expression of NQO1 mRNA
andrographolide results in increased expression of NQO1 protein
[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of NQO1 mRNA; andrographolide promotes the reaction [Acetaminophen results in increased expression of NQO1 mRNA]
CTD PMID:19737545, PMID:29355602 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Olr878 olfactory receptor 878 decreases expression ISO andrographolide results in decreased expression of OLFR767 mRNA CTD PMID:19737545 NCBI chr 7:3,498,768...3,499,697
Ensembl chr 7:3,498,768...3,499,697
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO andrographolide inhibits the reaction [TGFB1 protein results in increased expression of PCNA protein] CTD PMID:31706003 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pdzrn3 PDZ domain containing RING finger 3 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of PDZRN3 mRNA CTD PMID:19737545 NCBI chr 4:133,717,139...133,951,282
Ensembl chr 4:133,717,139...133,951,264
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 decreases expression ISO andrographolide results in decreased expression of PECAM1 protein CTD PMID:28651835 NCBI chr10:94,850,971...94,913,202 JBrowse link
G Phospho1 phosphoethanolamine/phosphocholine phosphatase 1 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of PHOSPHO1 mRNA CTD PMID:19737545 NCBI chr10:83,635,557...83,643,862
Ensembl chr10:83,636,518...83,643,859
JBrowse link
G Plscr1 phospholipid scramblase 1 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of PLSCR1 mRNA CTD PMID:19737545 NCBI chr 8:99,625,523...99,645,882
Ensembl chr 8:99,625,545...99,725,217
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of POR mRNA CTD PMID:19737545 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARG protein] CTD PMID:27475717 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ptgr1 prostaglandin reductase 1 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of LTB4DH mRNA CTD PMID:19737545 NCBI chr 5:76,110,746...76,129,361
Ensembl chr 5:76,110,738...76,129,441
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of RAF1 protein] CTD PMID:24814888 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO andrographolide results in decreased phosphorylation of RB1 protein CTD PMID:18619950 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G S100a4 S100 calcium-binding protein A4 multiple interactions EXP andrographolide inhibits the reaction [Bleomycin results in increased expression of S100A4 protein] CTD PMID:31706003 NCBI chr 2:189,997,278...189,999,587
Ensembl chr 2:189,997,129...189,999,604
JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of SCD1 mRNA]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of SCD1 protein] CTD PMID:27475717 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Serpina7 serpin family A member 7 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of SERPINA7 mRNA CTD PMID:19737545 NCBI chr  X:110,226,565...110,232,202
Ensembl chr  X:110,226,572...110,232,179
JBrowse link
G Slc1a4 solute carrier family 1 member 4 multiple interactions
increases expression
ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of SLC1A4 mRNA
andrographolide results in increased expression of SLC1A4 mRNA
CTD PMID:19737545 NCBI chr14:104,582,884...104,612,417
Ensembl chr14:104,581,190...104,612,597
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO andrographolide results in increased expression of SLC7A11 mRNA CTD PMID:19737545 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO andrographolide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] CTD PMID:31706003 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO andrographolide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:31706003 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Sod1 superoxide dismutase 1 increases expression EXP andrographolide results in increased expression of SOD1 mRNA; andrographolide results in increased expression of SOD1 protein CTD PMID:25110055 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of SPP1 mRNA CTD PMID:19737545 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO andrographolide results in increased expression of SQSTM1 protein CTD PMID:29355602 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Srxn1 sulfiredoxin 1 multiple interactions
increases expression
ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of SRXN1 mRNA
andrographolide results in increased expression of SRXN1 mRNA
CTD PMID:19737545 NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801
JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases activity
multiple interactions
ISO andrographolide results in decreased activity of STAT3 protein
andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of STAT3 protein]
andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of STAT3 protein]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of STAT3 protein]]
CTD PMID:23845849, PMID:31128153 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Steap4 STEAP4 metalloreductase multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of STEAP4 mRNA CTD PMID:19737545 NCBI chr 4:23,112,682...23,135,354
Ensembl chr 4:23,090,029...23,135,354
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase multiple interactions
increases expression
ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of TDO2 mRNA
andrographolide results in increased expression of TDO2 mRNA
CTD PMID:19737545 NCBI chr 2:180,897,059...180,914,919
Ensembl chr 2:180,897,011...180,914,940
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression
multiple interactions
ISO
EXP
andrographolide results in decreased expression of TGFB1 protein
andrographolide inhibits the reaction [TGFB1 protein results in decreased cleavage of CASP3 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of MMP2 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of MMP9 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of PCNA protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of TIMP1 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]
andrographolide inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]
TGFB1 protein inhibits the reaction [andrographolide results in increased expression of EGLN1 mRNA]; TGFB1 protein inhibits the reaction [andrographolide results in increased expression of EGLN1 protein]
CTD PMID:21134392, PMID:31706003 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Thbs1 thrombospondin 1 multiple interactions
decreases expression
ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of THBS1 mRNA
andrographolide results in decreased expression of THBS1 mRNA
CTD PMID:19737545 NCBI chr 3:109,862,120...109,873,466
Ensembl chr 3:109,862,117...109,873,466
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO andrographolide inhibits the reaction [TGFB1 protein results in increased expression of TIMP1 mRNA] CTD PMID:31706003 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tmprss11f transmembrane serine protease 11F multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of TMPRSS11F mRNA CTD PMID:19737545 NCBI chr14:23,982,415...24,080,477
Ensembl chr14:23,981,219...24,080,470
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP andrographolide inhibits the reaction [Copper Sulfate results in increased expression of TNF protein]; andrographolide inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein] CTD PMID:20946909, PMID:32061742 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO andrographolide results in increased expression of and results in increased phosphorylation of TP53 protein; Fluorouracil promotes the reaction [andrographolide results in increased expression of TP53] CTD PMID:18619950, PMID:19097688 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 multiple interactions
increases expression
ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of UGT1A6 mRNA
andrographolide results in increased expression of UGT1A6 mRNA
CTD PMID:19737545 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of VCAM1 mRNA CTD PMID:19737545 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression
ISO [andrographolide co-treated with KDR protein] inhibits the reaction [VEGFA protein binds to KDR protein]; andrographolide inhibits the reaction [HIF1A protein binds to VEGFA promoter]; andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein]; andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAP2K4 protein]; andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAP2K6 protein]; andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAP2K7 protein]; andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAP3K5 protein]; andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK1 protein]; andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK3 protein]; andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of RAF1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [andrographolide results in decreased expression of VEGFA mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [andrographolide results in decreased expression of VEGFA protein]; EGLN1 mutant form inhibits the reaction [andrographolide results in decreased expression of VEGFA protein]; pyrazolanthrone inhibits the reaction [andrographolide results in decreased expression of VEGFA mRNA]; pyrazolanthrone inhibits the reaction [andrographolide results in decreased expression of VEGFA protein]
andrographolide results in decreased expression of VEGFA mRNA; andrographolide results in decreased expression of VEGFA protein
CTD PMID:21134392, PMID:24814888, PMID:28651835 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vil1 villin 1 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of VIL1 mRNA CTD PMID:19737545 NCBI chr 9:81,689,802...81,717,623
Ensembl chr 9:81,689,802...81,717,621
JBrowse link
G Vim vimentin multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of VIM mRNA; andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of VIM protein]
andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of VIM protein]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of VIM protein]]
CTD PMID:19737545, PMID:31128153 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO andrographolide results in decreased expression of XIAP protein CTD PMID:23845849 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link
G Zg16b zymogen granule protein 16B multiple interactions
decreases expression
ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of SBPL mRNA
andrographolide results in decreased expression of SBPL mRNA
CTD PMID:19737545 NCBI chr10:13,320,716...13,325,134
Ensembl chr10:13,311,789...13,324,536
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        biochemical role 19281
          metabolite 19262
            andrographolide 135
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic ester 14073
                                        lactone 5978
                                          gamma-lactone 1214
                                            andrographolide 135
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.