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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:andrographolide
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Accession:CHEBI:65408 term browser browse the term
Definition:A labdane diterpenoid isolated from the leaves and roots of Andrographis paniculata that exhibits anti-HIV, anti-inflammatory and antineoplastic properties.
Synonyms:exact_synonym: (3E,4S)-4-hydroxy-3-{2-[(1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidenedecahydronaphthalen-1-yl]ethylidene}dihydrofuran-2(3H)-one
 related_synonym: (1R-(1-alpha(E(S)),4abeta,5alpha,6alpha,8aalpha))-3-(2-(decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl)ethylidene)dihydro-4-hydroxy-2(3H)-furanone;   3-(2-(decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenenaphthyl)ethylidene)dihydro-4-hydroxyfuran-2(3H)-one;   3alpha,14,15,18-tetrahydroxy-5b,9bH,10a-labda-8(20),12-dien-16-oic acid gamma-Lactone;   Formula=C20H30O5;   InChI=1S/C20H30O5/c1-12-4-7-16-19(2,9-8-17(23)20(16,3)11-21)14(12)6-5-13-15(22)10-25-18(13)24/h5,14-17,21-23H,1,4,6-11H2,2-3H3/b13-5+/t14-,15-,16+,17-,19+,20+/m1/s1;   InChIKey=BOJKULTULYSRAS-OTESTREVSA-N;   SMILES=[H][C@]12CCC(=C)[C@@H](C\\C=C3/[C@H](O)COC3=O)[C@]1(C)CC[C@@H](O)[C@@]2(C)CO
 xref: CAS:5508-58-7;   KEGG:C20214
 xref_mesh: MESH:C030419
 xref: PMID:15894448;   PMID:18464090;   PMID:19110075;   PMID:22026410;   PMID:22512591;   PMID:22858223;   Patent:CN102397273;   Patent:EP2411004;   Reaxys:5609598;   Wikipedia:Andrographolide


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andrographolide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of ABCC4 mRNA CTD PMID:19737545 NCBI chr15:101,948,387...102,182,912
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression
multiple interactions		 EXP
ISO		 andrographolide results in decreased expression of ACTA2 mRNA; andrographolide results in decreased expression of ACTA2 protein
andrographolide inhibits the reaction [Acetaminophen results in increased expression of ACTA2 mRNA]; andrographolide inhibits the reaction [Acetaminophen results in increased expression of ACTA2 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of ACTA2 protein]; NFE2L2 gene mutant form inhibits the reaction [andrographolide inhibits the reaction [Acetaminophen results in increased expression of ACTA2 protein]]
andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of ACTA2 mRNA]; andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of ACTA2 protein]; andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of ACTA2 protein]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of ACTA2 protein]]
andrographolide inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]		 CTD PMID:29355602 PMID:31128153 PMID:31706003 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of ADH7 mRNA CTD PMID:19737545 NCBI chr 2:226,748,724...226,763,183
Ensembl chr 2:226,741,788...226,763,182 		JBrowse link
G Ankrd1 ankyrin repeat domain 1 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of ANKRD1 mRNA CTD PMID:19737545 NCBI chr 1:243,228,460...243,237,014
Ensembl chr 1:233,815,851...233,834,919 		JBrowse link
G Atf2 activating transcription factor 2 multiple interactions ISO andrographolide inhibits the reaction [cobaltous chloride results in increased expression of ATF2 protein modified form]; DUSP10 protein promotes the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of ATF2 protein modified form]] CTD PMID:29165873 NCBI chr 3:79,125,814...79,202,896
Ensembl chr 3:58,718,332...58,795,236 		JBrowse link
G B4galt1 beta-1,4-galactosyltransferase 1 increases expression ISO andrographolide results in increased expression of B4GALT1 mRNA CTD PMID:35724838 NCBI chr 5:60,731,601...60,778,456
Ensembl chr 5:55,935,615...55,982,461 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO andrographolide results in increased expression of BAD protein CTD PMID:35917943 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects folding
multiple interactions
increases expression		 ISO andrographolide affects the folding of BAX protein
[andrographolide co-treated with Cisplatin] results in increased expression of BAX mRNA; andrographolide promotes the reaction [Cisplatin results in increased expression of BAX protein]; Fluorouracil promotes the reaction [andrographolide affects the folding of BAX protein]
andrographolide results in increased expression of BAX mRNA; andrographolide results in increased expression of BAX protein		 CTD PMID:19097688 PMID:23845849 PMID:24563380 PMID:35917943 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO andrographolide results in increased expression of BBC3 mRNA CTD PMID:35724838 NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO andrographolide results in decreased expression of BCL2 protein
[andrographolide co-treated with Cisplatin] results in decreased expression of BCL2 mRNA		 CTD PMID:23845849 PMID:24563380 PMID:35917943 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bhmt betaine-homocysteine S-methyltransferase multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of BHMT mRNA CTD PMID:19737545 NCBI chr 2:26,594,852...26,614,429
Ensembl chr 2:24,859,873...24,879,742 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
increases expression		 EXP
ISO		 andrographolide inhibits the reaction [Copper Sulfate results in decreased expression of and results in increased cleavage of BID protein]; andrographolide promotes the reaction [Penicillamine inhibits the reaction [Copper Sulfate results in decreased expression of and results in increased cleavage of BID protein]]; Penicillamine promotes the reaction [andrographolide inhibits the reaction [Copper Sulfate results in decreased expression of and results in increased cleavage of BID protein]]
andrographolide results in increased expression of BID mRNA; andrographolide results in increased expression of BID protein
[andrographolide co-treated with Cisplatin] results in increased expression of BID mRNA		 CTD PMID:20946909 PMID:24563380 NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 increases expression
multiple interactions		 ISO andrographolide results in increased expression of BIRC3 mRNA
[andrographolide co-treated with TNF protein] results in decreased expression of BIRC3 mRNA		 CTD PMID:35724838 NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO andrographolide results in decreased expression of BIRC5 protein CTD PMID:23845849 NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Blvrb biliverdin reductase B multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of BLVRB mRNA CTD PMID:19737545 NCBI chr 1:91,866,258...91,883,921
Ensembl chr 1:82,738,695...82,770,375 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases expression
increases cleavage		 ISO
EXP		 andrographolide results in increased activity of CASP3 protein
andrographolide inhibits the reaction [Copper Sulfate results in increased cleavage of CASP3 protein]; andrographolide promotes the reaction [Penicillamine inhibits the reaction [Copper Sulfate results in increased cleavage of CASP3 protein]]; Penicillamine promotes the reaction [andrographolide inhibits the reaction [Copper Sulfate results in increased cleavage of CASP3 protein]]
[andrographolide co-treated with Cisplatin] results in increased expression of CASP3 mRNA; CASP8 affects the reaction [Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP3 protein]]; Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP3 protein]
andrographolide results in increased expression of CASP3 mRNA
andrographolide inhibits the reaction [[Tobacco Smoke Pollution results in increased abundance of Particulate Matter] which results in increased cleavage of CASP3 protein]; andrographolide inhibits the reaction [TGFB1 protein results in decreased cleavage of CASP3 protein]
andrographolide results in increased cleavage of CASP3 protein		 CTD PMID:19097688 PMID:20946909 PMID:24563380 PMID:31706003 PMID:35917943 More... NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions
increases expression		 ISO
EXP		 andrographolide results in increased activity of CASP8 protein
andrographolide inhibits the reaction [Copper Sulfate results in increased activity of CASP8 protein]
[andrographolide co-treated with Cisplatin] results in increased expression of CASP8 mRNA; CASP8 affects the reaction [Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP3 protein]]; CASP8 affects the reaction [Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP9 protein]]; CASP8 results in increased susceptibility to [andrographolide co-treated with Fluorouracil]; Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP8 protein]
andrographolide results in increased expression of CASP8 mRNA		 CTD PMID:19097688 PMID:20946909 PMID:24563380 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
increases expression		 ISO
EXP		 andrographolide results in increased activity of CASP9 protein
[andrographolide co-treated with Cisplatin] results in increased expression of CASP9 mRNA; CASP8 affects the reaction [Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP9 protein]]; Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP9 protein]
andrographolide inhibits the reaction [Copper Sulfate results in increased activity of CASP9 protein]; andrographolide promotes the reaction [Penicillamine inhibits the reaction [Copper Sulfate results in increased activity of CASP9 protein]]; Penicillamine promotes the reaction [andrographolide inhibits the reaction [Copper Sulfate results in increased activity of CASP9 protein]]
andrographolide results in increased expression of CASP9 mRNA		 CTD PMID:19097688 PMID:20946909 PMID:24563380 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Cat catalase multiple interactions ISO
EXP		 [andrographolide co-treated with Polylactic Acid-Polyglycolic Acid Copolymer] inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; andrographolide inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]
andrographolide inhibits the reaction [Freund's Adjuvant results in decreased activity of CAT protein]		 CTD PMID:26485141 PMID:32061742 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cbr1 carbonyl reductase 1 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of CBR1 mRNA CTD PMID:19737545 NCBI chr11:46,346,405...46,348,815
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393 		JBrowse link
G Cbr3 carbonyl reductase 3 multiple interactions
increases expression		 ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of CBR3 mRNA
andrographolide results in increased expression of CBR3 mRNA		 CTD PMID:19737545 NCBI chr11:46,478,295...46,486,555
Ensembl chr11:33,008,615...33,016,875 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression		 ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CCL2 mRNA
andrographolide results in increased expression of CCL2 mRNA		 CTD PMID:19737545 PMID:35724838 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression ISO andrographolide results in increased expression of CCL20 mRNA CTD PMID:35724838 NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:84,388,904...84,391,629 		JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CCN2 mRNA CTD PMID:19737545 NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Ccna2 cyclin A2 multiple interactions
decreases expression		 ISO andrographolide inhibits the reaction [CCNA2 protein binds to CDK2 protein]
andrographolide results in decreased expression of CCNA2 protein		 CTD PMID:18619950 NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression		 ISO andrographolide inhibits the reaction [CCND1 protein binds to CDK4 protein]
andrographolide results in decreased expression of CCND1 protein		 CTD PMID:18619950 PMID:23845849 PMID:35917943 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccne1 cyclin E1 decreases expression
multiple interactions		 ISO andrographolide results in decreased expression of CCNE1 protein
andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCNE1 protein]		 CTD PMID:23845849 PMID:27475717 NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cdh1 cadherin 1 multiple interactions
increases expression		 ISO andrographolide inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 protein]
andrographolide inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 protein]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 protein]]
andrographolide results in increased expression of CDH1 protein		 CTD PMID:31128153 PMID:35917943 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdh17 cadherin 17 decreases expression
multiple interactions		 ISO andrographolide results in decreased expression of CDH17 mRNA
[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CDH17 mRNA		 CTD PMID:19737545 NCBI chr 5:30,024,544...30,112,226
Ensembl chr 5:25,262,758...25,314,884 		JBrowse link
G Cdh2 cadherin 2 multiple interactions
decreases expression		 ISO andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 protein]
andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 protein]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 protein]]
andrographolide results in decreased expression of CDH2 protein		 CTD PMID:31128153 PMID:35917943 NCBI chr18:8,051,097...8,265,288
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression
multiple interactions		 ISO andrographolide results in decreased expression of CDK2 protein
andrographolide inhibits the reaction [CCNA2 protein binds to CDK2 protein]
andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CDK2 protein]		 CTD PMID:18619950 PMID:27475717 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions
decreases expression		 ISO andrographolide inhibits the reaction [CCND1 protein binds to CDK4 protein]
andrographolide results in decreased expression of CDK4 protein		 CTD PMID:18619950 NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO andrographolide results in increased expression of CDKN1A protein CTD PMID:18619950 PMID:23845849 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO andrographolide affects the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] affects the expression of CEBPA mRNA]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CEBPA protein] CTD PMID:27475717 NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:87,759,433...87,762,412 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions ISO andrographolide affects the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] affects the expression of CEBPB mRNA]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of and results in increased phosphorylation of CEBPB protein] CTD PMID:27475717 NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:156,397,052...156,399,473 		JBrowse link
G Ces3a carboxylesterase 3a multiple interactions
increases expression		 ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of CES3 mRNA
andrographolide results in increased expression of CES3 mRNA		 CTD PMID:19737545 NCBI chr19:49,902,312...49,910,484 JBrowse link
G Cish cytokine inducible SH2-containing protein multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CISH mRNA CTD PMID:19737545 NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250 		JBrowse link
G Cnn2 calponin 2 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CNN2 mRNA CTD PMID:19737545 NCBI chr 7:10,363,141...10,370,312
Ensembl chr 7:9,712,516...9,719,656 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
decreases expression		 ISO
EXP		 andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of COL1A1 mRNA]
andrographolide results in decreased expression of COL1A1 mRNA
andrographolide inhibits the reaction [Acetaminophen results in increased expression of COL1A1 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]		 CTD PMID:29355602 PMID:31706003 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col1a2 collagen type I alpha 2 chain decreases expression
multiple interactions		 ISO
EXP		 andrographolide results in decreased expression of COL1A2 mRNA
andrographolide inhibits the reaction [Acetaminophen results in increased expression of COL1A2 mRNA]		 CTD PMID:29355602 NCBI chr 4:33,518,557...33,553,484
Ensembl chr 4:32,563,381...32,598,867 		JBrowse link
G Col3a1 collagen type III alpha 1 chain decreases expression
multiple interactions		 EXP
ISO		 andrographolide results in decreased expression of COL3A1 mRNA
andrographolide inhibits the reaction [Acetaminophen results in increased expression of COL3A1 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 protein]
andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of COL3A1 mRNA]		 CTD PMID:29355602 PMID:31706003 NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Crct1 cysteine-rich C-terminal 1 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CRCT1 mRNA CTD PMID:19737545 NCBI chr 2:178,633,789...178,635,274
Ensembl chr 2:178,634,092...178,634,394 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression		 ISO KYA1797K promotes the reaction [andrographolide results in decreased expression of CTNNB1 protein] CTD PMID:35917943 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions
increases expression		 ISO [andrographolide co-treated with TNF protein] results in decreased expression of CXCL1 mRNA
andrographolide results in increased expression of CXCL1 mRNA		 CTD PMID:35724838 NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cxcl13 C-X-C motif chemokine ligand 13 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CXCL13 mRNA CTD PMID:19737545 NCBI chr14:13,912,858...13,917,920
Ensembl chr14:13,608,902...13,613,933 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions
increases expression		 EXP
ISO		 andrographolide inhibits the reaction [Freund's Adjuvant results in increased expression of CXCL2 protein]
andrographolide results in increased expression of CXCL2 mRNA		 CTD PMID:32061742 PMID:35724838 NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions
increases expression		 ISO [andrographolide co-treated with TNF protein] results in decreased expression of CXCL1 mRNA
andrographolide results in increased expression of CXCL1 mRNA		 CTD PMID:35724838 NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CYP17A1 mRNA CTD PMID:19737545 NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases activity
increases expression		 ISO [andrographolide co-treated with benz(a)anthracene] results in increased expression of CYP1A1 mRNA; [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of CYP1A1 mRNA; [andrographolide co-treated with Tetrachlorodibenzodioxin] results in increased expression of CYP1A1 mRNA; Acetylcysteine affects the reaction [andrographolide affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]]; andrographolide affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; andrographolide promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Ascorbic Acid affects the reaction [andrographolide affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]]; beta-Naphthoflavone promotes the reaction [andrographolide results in increased expression of CYP1A1 mRNA]; Buthionine Sulfoximine promotes the reaction [andrographolide affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]]; Glutathione affects the reaction [andrographolide affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]]; Hydrogen Peroxide promotes the reaction [andrographolide affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]]; resveratrol inhibits the reaction [[andrographolide co-treated with benz(a)anthracene] results in increased expression of CYP1A1 mRNA]
andrographolide results in increased activity of CYP1A1 protein		 CTD PMID:17825862 PMID:19737545 PMID:21094198 PMID:21963808 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases expression
multiple interactions
increases expression		 ISO
EXP		 andrographolide results in decreased expression of CYP1A2 mRNA
[andrographolide co-treated with benz(a)anthracene] results in increased expression of CYP1A2 mRNA; [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of CYP1A2 mRNA
andrographolide results in increased expression of CYP1A2 mRNA
andrographolide affects the reaction [CYP1A2 protein results in increased metabolism of Theophylline]		 CTD PMID:17825862 PMID:19041297 PMID:19737545 PMID:20096675 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO [andrographolide co-treated with benz(a)anthracene] results in increased expression of CYP1B1 mRNA; andrographolide promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1B1 mRNA] CTD PMID:17825862 PMID:19737545 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 increases expression
multiple interactions		 ISO andrographolide results in increased expression of CYP2A4 mRNA
beta-Naphthoflavone promotes the reaction [andrographolide results in increased expression of CYP2A4 mRNA]		 CTD PMID:19737545 NCBI chr 1:91,299,584...91,307,650
Ensembl chr 1:82,169,949...82,179,979 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases activity
multiple interactions
increases expression		 ISO andrographolide results in increased activity of CYP2B10 protein
[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of CYP2B10 mRNA
andrographolide results in increased expression of CYP2B10 mRNA		 CTD PMID:19737545 PMID:21094198 NCBI chr 1:90,780,468...90,859,852
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases expression EXP andrographolide results in decreased expression of CYP2C11 mRNA; andrographolide results in decreased expression of CYP2C11 protein CTD PMID:19041297 NCBI chr 1:246,175,216...246,211,445
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases expression ISO andrographolide results in decreased expression of CYP3A4 mRNA CTD PMID:19041297 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 decreases expression EXP andrographolide results in decreased expression of CYP3A23-3A1 mRNA CTD PMID:19041297 NCBI chr12:14,369,950...14,398,803
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 increases expression ISO andrographolide results in increased expression of CYP8B1 mRNA CTD PMID:19737545 NCBI chr 8:130,455,622...130,457,592
Ensembl chr 8:121,557,062...121,580,166 		JBrowse link
G Ddc dopa decarboxylase multiple interactions
increases expression		 ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of DDC mRNA
andrographolide results in increased expression of DDC mRNA		 CTD PMID:19737545 NCBI chr14:90,592,304...90,682,830
Ensembl chr14:86,378,685...86,469,208 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO andrographolide results in increased expression of DDIT3 protein CTD PMID:35724838 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dusp10 dual specificity phosphatase 10 increases expression
multiple interactions		 ISO andrographolide results in increased expression of DUSP10 mRNA; andrographolide results in increased expression of DUSP10 protein
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [andrographolide results in increased expression of DUSP10 mRNA]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [andrographolide results in increased expression of DUSP10 protein]; DUSP10 protein promotes the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of ATF2 protein modified form]]; DUSP10 protein promotes the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]]; HMOX1 protein promotes the reaction [andrographolide results in increased expression of DUSP10 protein]; zinc protoporphyrin inhibits the reaction [andrographolide results in increased expression of DUSP10 mRNA]; zinc protoporphyrin inhibits the reaction [andrographolide results in increased expression of DUSP10 protein]		 CTD PMID:29165873 NCBI chr13:98,145,317...98,183,304
Ensembl chr13:95,614,292...95,651,716 		JBrowse link
G Edn1 endothelin 1 multiple interactions
increases expression		 ISO andrographolide inhibits the reaction [cobaltous chloride results in increased expression of EDN1 mRNA]; andrographolide inhibits the reaction [cobaltous chloride results in increased expression of EDN1 protein]; Vanadates inhibits the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of EDN1 mRNA]]; Vanadates inhibits the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of EDN1 protein]]
andrographolide results in increased expression of EDN1 mRNA		 CTD PMID:27297870 PMID:29165873 PMID:35724838 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 multiple interactions
increases expression		 ISO EGLN1 mutant form inhibits the reaction [andrographolide results in decreased expression of HIF1A protein]; EGLN1 mutant form inhibits the reaction [andrographolide results in decreased expression of VEGFA protein]; TGFB1 protein inhibits the reaction [andrographolide results in increased expression of EGLN1 mRNA]; TGFB1 protein inhibits the reaction [andrographolide results in increased expression of EGLN1 protein]
andrographolide results in increased expression of EGLN1 mRNA; andrographolide results in increased expression of EGLN1 protein		 CTD PMID:21134392 PMID:27297870 NCBI chr19:69,765,276...69,804,681
Ensembl chr19:52,869,486...52,907,777 		JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 increases expression ISO andrographolide results in increased expression of EGLN3 protein CTD PMID:27297870 NCBI chr 6:77,385,549...77,411,015
Ensembl chr 6:71,650,297...71,675,766 		JBrowse link
G Eid3 EP300 interacting inhibitor of differentiation 3 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of EID3 mRNA CTD PMID:19737545 NCBI chr 7:20,860,073...20,861,395 JBrowse link
G Elane elastase, neutrophil expressed multiple interactions EXP andrographolide inhibits the reaction [Freund's Adjuvant results in increased expression of ELANE protein] CTD PMID:32061742 NCBI chr 7:10,467,877...10,469,725
Ensembl chr 7:9,817,252...9,819,100 		JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit multiple interactions ISO andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of EZH2 protein]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of EZH2 protein]] CTD PMID:31128153 NCBI chr 4:77,624,223...77,698,598
Ensembl chr 4:76,624,399...76,687,362 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions
increases expression		 ISO [andrographolide co-treated with Cisplatin] promotes the reaction [FAS protein binds to FASLG protein]; [andrographolide co-treated with Cisplatin] results in increased expression of FAS mRNA; [andrographolide co-treated with Cisplatin] results in increased expression of FAS protein; andrographolide promotes the reaction [FAS protein binds to FASLG protein]
andrographolide results in increased expression of FAS mRNA; andrographolide results in increased expression of FAS protein		 CTD PMID:24563380 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand multiple interactions
increases expression		 ISO [andrographolide co-treated with Cisplatin] promotes the reaction [FAS protein binds to FASLG protein]; [andrographolide co-treated with Cisplatin] results in increased expression of FASLG mRNA; [andrographolide co-treated with Cisplatin] results in increased expression of FASLG protein; andrographolide promotes the reaction [FAS protein binds to FASLG protein]
andrographolide results in increased expression of FASLG mRNA; andrographolide results in increased expression of FASLG protein		 CTD PMID:24563380 NCBI chr13:76,680,885...76,706,042
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fasn fatty acid synthase multiple interactions ISO andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of FASN mRNA]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of FASN protein] CTD PMID:27475717 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 decreases expression ISO andrographolide results in decreased expression of FLT1 mRNA CTD PMID:28651835 NCBI chr12:12,333,050...12,504,750
Ensembl chr12:7,297,292...7,468,626 		JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO andrographolide inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein] CTD PMID:31706003 NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO andrographolide results in decreased localization of and results in decreased activity of FOS protein CTD PMID:19426720 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
decreases expression		 EXP
ISO		 andrographolide results in increased expression of GCLC mRNA; andrographolide results in increased expression of GCLC protein
andrographolide inhibits the reaction [Acetaminophen results in decreased expression of GCLC mRNA]
andrographolide results in decreased expression of GCLC mRNA
[andrographolide co-treated with TNF protein] results in increased expression of GCLC mRNA		 CTD PMID:25110055 PMID:29355602 PMID:35724838 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions
increases expression
decreases expression		 ISO
EXP		 [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of GCLM mRNA; andrographolide inhibits the reaction [Acetaminophen results in decreased expression of GCLM mRNA]
andrographolide results in increased expression of GCLM mRNA; andrographolide results in increased expression of GCLM protein
andrographolide results in decreased expression of GCLM mRNA
[andrographolide co-treated with TNF protein] results in increased expression of GCLM mRNA		 CTD PMID:19737545 PMID:25110055 PMID:29355602 PMID:35724838 NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO [polylactic acid-polyglycolic acid copolymer co-treated with andrographolide] inhibits the reaction [sodium arsenite results in increased activity of GPT protein] CTD PMID:26485141 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gsdmd gasdermin D multiple interactions ISO andrographolide inhibits the reaction [[Tobacco Smoke Pollution results in increased abundance of Particulate Matter] which results in increased cleavage of GSDMD protein] CTD PMID:37987454 NCBI chr 7:109,423,209...109,427,771
Ensembl chr 7:107,542,083...107,547,055 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
decreases phosphorylation		 ISO andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of GSK3B protein]
andrographolide results in decreased phosphorylation of GSK3B protein		 CTD PMID:27475717 PMID:35917943 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gsr glutathione-disulfide reductase increases activity EXP andrographolide results in increased activity of GSR protein CTD PMID:25110055 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of GSTM2 mRNA CTD PMID:19737545 NCBI chr 2:198,312,179...198,316,962
Ensembl chr 2:195,544,426...195,628,961 		JBrowse link
G Gstm4 glutathione S-transferase mu 4 increases expression
multiple interactions		 ISO andrographolide results in increased expression of GSTM4 mRNA
[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of GSTM4 mRNA		 CTD PMID:19737545 NCBI chr 2:198,356,114...198,373,487
Ensembl chr 2:195,680,004...195,685,323 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 increases expression
multiple interactions		 ISO andrographolide results in increased expression of GSTM3 mRNA
[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of GSTM3 mRNA		 CTD PMID:19737545 NCBI chr 2:198,219,769...198,222,732
Ensembl chr 2:195,531,495...195,534,553 		JBrowse link
G Hdac1 histone deacetylase 1 decreases expression ISO andrographolide results in decreased expression of HDAC1 protein CTD PMID:28651835 NCBI chr 5:147,138,328...147,165,387
Ensembl chr 5:141,853,989...141,881,111 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases expression
decreases expression		 ISO [andrographolide co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased ubiquitination of HIF1A protein; [andrographolide co-treated with cobaltous chloride] results in increased hydroxylation of HIF1A protein; andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]; andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; andrographolide inhibits the reaction [HIF1A protein binds to VEGFA promoter]; andrographolide results in decreased expression of and affects the localization of HIF1A protein; andrographolide results in decreased expression of and results in increased degradation of HIF1A protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [andrographolide results in decreased expression of HIF1A protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [andrographolide results in increased degradation of HIF1A protein]; DUSP10 protein promotes the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]]; EGLN1 mutant form inhibits the reaction [andrographolide results in decreased expression of HIF1A protein]; HMOX1 protein affects the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]]; NFE2L2 protein affects the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]]; pyrazolanthrone inhibits the reaction [andrographolide results in decreased expression of HIF1A protein]; Vanadates inhibits the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]]; Vanadates inhibits the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]]
andrographolide results in increased expression of HIF1A protein modified form		 CTD PMID:21134392 PMID:27297870 PMID:28651835 PMID:29165873 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
decreases expression		 EXP
ISO		 andrographolide results in increased expression of HMOX1 mRNA; andrographolide results in increased expression of HMOX1 protein
[andrographolide co-treated with TNF protein] results in increased expression of HMOX1 mRNA; HMOX1 protein affects the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]]; HMOX1 protein promotes the reaction [andrographolide results in increased expression of DUSP10 protein]
andrographolide inhibits the reaction [Acetaminophen results in decreased expression of HMOX1 mRNA]
andrographolide results in decreased expression of HMOX1 mRNA		 CTD PMID:25110055 PMID:27297870 PMID:29165873 PMID:29355602 PMID:35724838 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hp haptoglobin multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of HP mRNA CTD PMID:19737545 NCBI chr19:54,449,151...54,453,701
Ensembl chr19:37,539,627...37,544,523 		JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of HPGD mRNA CTD PMID:19737545 NCBI chr16:38,996,876...39,034,831
Ensembl chr16:33,986,266...34,024,228 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO [andrographolide co-treated with TNF protein] results in decreased expression of ICAM1 mRNA; andrographolide inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; andrographolide inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:35724838 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of IKBKE mRNA CTD PMID:19737545 NCBI chr13:45,264,404...45,290,737
Ensembl chr13:42,712,159...42,737,143 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO andrographolide inhibits the reaction [IL1B protein affects the localization of NFKBIA protein]; andrographolide inhibits the reaction [IL1B protein affects the localization of RELA protein]; andrographolide inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; andrographolide inhibits the reaction [IL1B protein results in increased expression of TNFAIP3 protein]
andrographolide inhibits the reaction [[Tobacco Smoke Pollution results in increased abundance of Particulate Matter] which results in increased secretion of IL1B protein]		 CTD PMID:35724838 PMID:37987454 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 multiple interactions EXP andrographolide inhibits the reaction [Lipopolysaccharides results in increased expression of IL2 protein] CTD PMID:38229310 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP		 andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of IL6 protein]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 protein]]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of ACTA2 protein]]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 protein]]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of EZH2 protein]]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of HOTAIR mRNA]]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of VIM protein]]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of STAT3 protein]]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of IL6 protein]]
andrographolide inhibits the reaction [[Tobacco Smoke Pollution results in increased abundance of Particulate Matter] which results in increased secretion of IL6 protein]; andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of IL6 mRNA]; andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of IL6 protein]
andrographolide inhibits the reaction [Freund's Adjuvant results in increased expression of IL6 protein]; andrographolide inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]		 CTD PMID:31128153 PMID:32061742 PMID:37987454 PMID:38229310 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins1 insulin 1 multiple interactions ISO andrographolide affects the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] affects the expression of CEBPA mRNA]; andrographolide affects the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] affects the expression of CEBPB mRNA]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of and results in increased phosphorylation of CEBPB protein]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCNE1 protein]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CDK2 protein]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CEBPA protein]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of FASN mRNA]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of FASN protein]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARG protein]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of SCD1 mRNA]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of SCD1 protein]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of GSK3B protein]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of MAPK1 protein]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of MAPK3 protein] CTD PMID:27475717 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO andrographolide results in decreased localization of and results in decreased activity of JUN protein CTD PMID:19426720 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kdr kinase insert domain receptor multiple interactions
decreases expression		 ISO [andrographolide co-treated with KDR protein] inhibits the reaction [VEGFA protein binds to KDR protein]; andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein]
andrographolide results in decreased expression of KDR mRNA		 CTD PMID:24814888 PMID:28651835 NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 decreases expression ISO andrographolide results in decreased expression of KEAP1 mRNA; andrographolide results in decreased expression of KEAP1 protein CTD PMID:29355602 PMID:35724838 NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Krt5 keratin 5 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of KRT5 mRNA CTD PMID:19737545 NCBI chr 7:134,724,840...134,730,569
Ensembl chr 7:132,846,136...132,851,850 		JBrowse link
G Mafg MAF bZIP transcription factor G decreases expression ISO andrographolide results in decreased expression of MAFG mRNA CTD PMID:35724838 NCBI chr10:106,401,633...106,410,159
Ensembl chr10:105,903,237...105,912,026 		JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 multiple interactions ISO andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAP2K4 protein] CTD PMID:24814888 NCBI chr10:50,842,348...50,947,063
Ensembl chr10:50,344,915...50,447,993 		JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 multiple interactions ISO andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAP2K6 protein] CTD PMID:24814888 NCBI chr10:95,872,747...95,987,747
Ensembl chr10:95,373,204...95,488,293 		JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 multiple interactions ISO andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAP2K7 protein] CTD PMID:24814888 NCBI chr12:7,389,032...7,398,377
Ensembl chr12:2,591,219...2,604,222 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 multiple interactions ISO andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAP3K5 protein] CTD PMID:24814888 NCBI chr 1:16,505,387...16,723,899
Ensembl chr 1:14,685,492...14,904,800 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK1 protein]
andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of MAPK1 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]		 CTD PMID:24814888 PMID:27475717 PMID:31706003 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK3 protein]
andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of MAPK3 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein]		 CTD PMID:24814888 PMID:27475717 PMID:31706003 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression		 ISO andrographolide inhibits the reaction [TGFB1 protein results in increased expression of MMP2 mRNA]
andrographolide results in decreased expression of MMP2 protein		 CTD PMID:31706003 PMID:35917943 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp7 matrix metallopeptidase 7 decreases expression
multiple interactions		 ISO andrographolide results in decreased expression of MMP7 mRNA; andrographolide results in decreased expression of MMP7 protein
andrographolide results in decreased expression of and results in decreased activity of MMP7 protein		 CTD PMID:19426720 PMID:35917943 NCBI chr 8:13,133,043...13,140,761
Ensembl chr 8:4,848,186...4,855,902 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression		 ISO andrographolide inhibits the reaction [TGFB1 protein results in increased expression of MMP9 mRNA]
andrographolide results in decreased expression of MMP9 protein		 CTD PMID:31706003 PMID:35917943 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP andrographolide inhibits the reaction [Freund's Adjuvant results in increased expression of MPO protein] CTD PMID:32061742 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mta1 metastasis associated 1 decreases expression ISO andrographolide results in decreased expression of MTA1 mRNA; andrographolide results in decreased expression of MTA1 protein CTD PMID:28651835 NCBI chr 6:137,999,845...138,038,696
Ensembl chr 6:132,178,853...132,217,641 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO andrographolide results in decreased expression of MYC protein CTD PMID:35917943 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Myo18b myosin XVIIIb decreases expression ISO andrographolide results in decreased expression of MYO18B mRNA CTD PMID:19737545 NCBI chr12:49,421,062...49,614,127
Ensembl chr12:43,747,010...43,953,695 		JBrowse link
G Necab1 N-terminal EF-hand calcium binding protein 1 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of NECAB1 mRNA CTD PMID:19737545 NCBI chr 5:33,155,078...33,375,707
Ensembl chr 5:28,357,859...28,578,642
Ensembl chr 5:28,357,859...28,578,642 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases activity
multiple interactions
decreases response to substance		 EXP
ISO		 andrographolide results in increased activity of NFE2L2 protein
andrographolide results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [andrographolide inhibits the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]]
NFE2L2 gene mutant form inhibits the reaction [andrographolide inhibits the reaction [Acetaminophen results in increased expression of ACTA2 protein]]
NFE2L2 gene mutant form results in decreased susceptibility to andrographolide		 CTD PMID:25110055 PMID:27297870 PMID:29355602 PMID:35724838 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO andrographolide inhibits the reaction [IL1B protein affects the localization of NFKBIA protein]; andrographolide inhibits the reaction [TNF protein affects the localization of NFKBIA protein] CTD PMID:35724838 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nfkbie NFKB inhibitor epsilon increases expression ISO andrographolide results in increased expression of NFKBIE mRNA CTD PMID:35724838 NCBI chr 9:22,941,037...22,947,872
Ensembl chr 9:15,436,941...15,450,437 		JBrowse link
G Ngb neuroglobin multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of NGB mRNA CTD PMID:19737545 NCBI chr 6:112,475,332...112,480,786
Ensembl chr 6:106,744,378...106,749,830 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO andrographolide inhibits the reaction [[Tobacco Smoke Pollution results in increased abundance of Particulate Matter] which results in increased expression of NLRP3 protein] CTD PMID:37987454 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP andrographolide inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein] CTD PMID:38229310 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP andrographolide inhibits the reaction [Lipopolysaccharides results in decreased activity of NOS3 protein] CTD PMID:38229310 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
decreases expression		 ISO
EXP		 andrographolide results in increased expression of NQO1 mRNA
[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of NQO1 mRNA; andrographolide promotes the reaction [Acetaminophen results in increased expression of NQO1 mRNA]
andrographolide results in increased expression of NQO1 protein
andrographolide results in decreased expression of NQO1 mRNA		 CTD PMID:19737545 PMID:29355602 PMID:35724838 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 increases expression ISO andrographolide results in increased expression of OLR1 mRNA CTD PMID:35724838 NCBI chr 4:164,612,460...164,635,082
Ensembl chr 4:162,926,439...162,948,523 		JBrowse link
G Or6c8 olfactory receptor family 6 subfamily C member 8 decreases expression ISO andrographolide results in decreased expression of OR6C8 mRNA CTD PMID:19737545 NCBI chr 7:2,086,602...2,087,531
Ensembl chr 7:1,501,940...1,507,336 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO andrographolide results in increased cleavage of PARP1 protein CTD PMID:35917943 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
decreases expression		 ISO andrographolide inhibits the reaction [TGFB1 protein results in increased expression of PCNA protein]
andrographolide results in decreased expression of PCNA protein		 CTD PMID:31706003 PMID:35917943 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pdgfb platelet derived growth factor subunit B increases expression ISO andrographolide results in increased expression of PDGFB mRNA CTD PMID:35724838 NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:111,540,345...111,557,984 		JBrowse link
G Pdzrn3 PDZ domain containing RING finger 3 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of PDZRN3 mRNA CTD PMID:19737545 NCBI chr 4:133,770,736...133,996,959
Ensembl chr 4:133,770,736...133,996,959 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 decreases expression ISO andrographolide results in decreased expression of PECAM1 protein CTD PMID:28651835 NCBI chr10:92,090,263...92,152,002
Ensembl chr10:91,590,521...91,652,116 		JBrowse link
G Phospho1 phosphoethanolamine/phosphocholine phosphatase 1 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of PHOSPHO1 mRNA CTD PMID:19737545 NCBI chr10:81,258,810...81,266,345
Ensembl chr10:80,760,792...80,770,342 		JBrowse link
G Plau plasminogen activator, urokinase increases expression ISO andrographolide results in increased expression of PLAU mRNA CTD PMID:35724838 NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Plscr1 phospholipid scramblase 1 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of PLSCR1 mRNA CTD PMID:19737545 NCBI chr 8:101,662,512...101,684,474
Ensembl chr 8:92,784,356...92,804,692 		JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of POR mRNA CTD PMID:19737545 NCBI chr12:26,587,674...26,655,612
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARG protein] CTD PMID:27475717 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Prkag2 protein kinase AMP-activated non-catalytic subunit gamma 2 increases expression ISO andrographolide results in increased expression of PRKAG2 mRNA CTD PMID:35724838 NCBI chr 4:10,744,695...10,985,939
Ensembl chr 4:10,010,890...10,252,142 		JBrowse link
G Ptgr1 prostaglandin reductase 1 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of PTGR1 mRNA CTD PMID:19737545 NCBI chr 5:78,579,060...78,597,671
Ensembl chr 5:73,784,009...73,802,666 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of RAF1 protein] CTD PMID:24814888 NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO andrographolide results in decreased phosphorylation of RB1 protein CTD PMID:18619950 NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO andrographolide inhibits the reaction [IL1B protein affects the localization of RELA protein]; andrographolide inhibits the reaction [TNF protein affects the localization of RELA protein]; andrographolide results in decreased expression of and results in decreased localization of RELA protein; pyrrolidine dithiocarbamic acid promotes the reaction [andrographolide results in decreased expression of and results in decreased localization of RELA protein] CTD PMID:35724838 PMID:35917943 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G S100a4 S100 calcium-binding protein A4 multiple interactions EXP andrographolide inhibits the reaction [Bleomycin results in increased expression of S100A4 protein] CTD PMID:31706003 NCBI chr 2:178,388,529...178,390,838
Ensembl chr 2:176,091,804...176,093,254 		JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of SCD1 mRNA]; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of SCD1 protein] CTD PMID:27475717 NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Serpina7 serpin family A member 7 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of SERPINA7 mRNA CTD PMID:19737545 NCBI chr  X:107,452,044...107,510,958
Ensembl chr  X:102,663,405...102,669,040 		JBrowse link
G Slc1a4 solute carrier family 1 member 4 multiple interactions
increases expression		 ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of SLC1A4 mRNA
andrographolide results in increased expression of SLC1A4 mRNA		 CTD PMID:19737545 NCBI chr14:98,718,646...98,761,672
Ensembl chr14:94,529,084...94,560,418 		JBrowse link
G Slc3a2 solute carrier family 3 member 2 decreases expression ISO andrographolide results in decreased expression of SLC3A2 mRNA CTD PMID:35724838 NCBI chr 1:215,033,601...215,048,064
Ensembl chr 1:205,604,468...205,618,931 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO andrographolide results in increased expression of SLC7A11 mRNA CTD PMID:19737545 NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO andrographolide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] CTD PMID:31706003 NCBI chr18:72,124,792...72,193,345
Ensembl chr18:69,850,377...69,912,323 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO andrographolide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:31706003 NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Snai1 snail family transcriptional repressor 1 decreases expression ISO andrographolide results in decreased expression of SNAI1 protein CTD PMID:35917943 NCBI chr 3:176,667,476...176,671,965
Ensembl chr 3:156,248,485...156,252,969 		JBrowse link
G Sod1 superoxide dismutase 1 increases expression EXP andrographolide results in increased expression of SOD1 mRNA; andrographolide results in increased expression of SOD1 protein CTD PMID:25110055 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of SPP1 mRNA CTD PMID:19737545 NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Sqstm1 sequestosome 1 increases expression
decreases expression		 ISO andrographolide results in increased expression of SQSTM1 protein
andrographolide results in decreased expression of SQSTM1 mRNA		 CTD PMID:29355602 PMID:35724838 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Srxn1 sulfiredoxin 1 multiple interactions
increases expression
decreases expression		 ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of SRXN1 mRNA
andrographolide results in increased expression of SRXN1 mRNA
andrographolide results in increased expression of SRXN1 protein
[andrographolide co-treated with TNF protein] results in increased expression of SRXN1 mRNA
andrographolide results in decreased expression of SRXN1 mRNA		 CTD PMID:19737545 PMID:35724838 NCBI chr 3:161,064,812...161,070,372
Ensembl chr 3:140,599,608...140,628,448 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases activity
multiple interactions		 ISO andrographolide results in decreased activity of STAT3 protein
andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of STAT3 protein]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of STAT3 protein]]		 CTD PMID:23845849 PMID:31128153 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Steap4 STEAP4 metalloreductase multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of STEAP4 mRNA CTD PMID:19737545 NCBI chr 4:27,032,096...27,054,769
Ensembl chr 4:26,054,671...26,099,859 		JBrowse link
G Tap1 transporter 1, ATP binding cassette subfamily B member increases expression ISO andrographolide results in increased expression of TAP1 mRNA CTD PMID:35724838 NCBI chr20:4,658,171...4,668,543
Ensembl chr20:4,656,263...4,666,901 		JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase multiple interactions
increases expression		 ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of TDO2 mRNA
andrographolide results in increased expression of TDO2 mRNA		 CTD PMID:19737545 NCBI chr 2:169,567,656...169,585,586
Ensembl chr 2:167,269,579...167,287,511 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression
multiple interactions		 ISO
EXP		 andrographolide results in decreased expression of TGFB1 protein
TGFB1 protein inhibits the reaction [andrographolide results in increased expression of EGLN1 mRNA]; TGFB1 protein inhibits the reaction [andrographolide results in increased expression of EGLN1 protein]
andrographolide inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]
andrographolide inhibits the reaction [TGFB1 protein results in decreased cleavage of CASP3 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of MMP2 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of MMP9 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of PCNA protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased expression of TIMP1 mRNA]; andrographolide inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]; andrographolide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]		 CTD PMID:21134392 PMID:31706003 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Thbs1 thrombospondin 1 multiple interactions
decreases expression		 ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of THBS1 mRNA
andrographolide results in decreased expression of THBS1 mRNA		 CTD PMID:19737545 NCBI chr 3:125,510,250...125,525,402
Ensembl chr 3:105,056,292...105,071,440 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO andrographolide inhibits the reaction [TGFB1 protein results in increased expression of TIMP1 mRNA] CTD PMID:31706003 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tmprss11f transmembrane serine protease 11F multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of TMPRSS11F mRNA CTD PMID:19737545 NCBI chr14:21,849,088...21,889,613
Ensembl chr14:21,429,418...21,534,809 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO		 andrographolide inhibits the reaction [Copper Sulfate results in increased expression of TNF protein]; andrographolide inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]; andrographolide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
[andrographolide co-treated with TNF protein] results in decreased expression of BIRC3 mRNA; [andrographolide co-treated with TNF protein] results in decreased expression of CXCL1 mRNA; [andrographolide co-treated with TNF protein] results in decreased expression of ICAM1 mRNA; [andrographolide co-treated with TNF protein] results in decreased expression of TNFAIP3 mRNA; [andrographolide co-treated with TNF protein] results in increased expression of GCLC mRNA; [andrographolide co-treated with TNF protein] results in increased expression of GCLM mRNA; [andrographolide co-treated with TNF protein] results in increased expression of HMOX1 mRNA; [andrographolide co-treated with TNF protein] results in increased expression of SRXN1 mRNA; andrographolide inhibits the reaction [TNF protein affects the localization of NFKBIA protein]; andrographolide inhibits the reaction [TNF protein affects the localization of RELA protein]; andrographolide inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; andrographolide inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]		 CTD PMID:20946909 PMID:32061742 PMID:35724838 PMID:38229310 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 increases expression
multiple interactions		 ISO andrographolide results in increased expression of TNFAIP3 mRNA; andrographolide results in increased expression of TNFAIP3 protein
[andrographolide co-treated with TNF protein] results in decreased expression of TNFAIP3 mRNA; andrographolide inhibits the reaction [IL1B protein results in increased expression of TNFAIP3 protein]; andrographolide inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]		 CTD PMID:35724838 NCBI chr 1:15,528,921...15,543,993
Ensembl chr 1:13,709,206...13,725,282 		JBrowse link
G Tnfrsf9 TNF receptor superfamily member 9 increases expression ISO andrographolide results in increased expression of TNFRSF9 mRNA CTD PMID:35724838 NCBI chr 5:166,664,494...166,690,834
Ensembl chr 5:161,381,662...161,408,000 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression		 ISO andrographolide results in increased expression of and results in increased phosphorylation of TP53 protein; Fluorouracil promotes the reaction [andrographolide results in increased expression of TP53] CTD PMID:18619950 PMID:19097688 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Trib3 tribbles pseudokinase 3 decreases expression ISO andrographolide results in decreased expression of TRIB3 mRNA CTD PMID:35724838 NCBI chr 3:161,269,939...161,275,533
Ensembl chr 3:140,809,043...140,814,497 		JBrowse link
G Txnip thioredoxin interacting protein multiple interactions ISO andrographolide inhibits the reaction [[Tobacco Smoke Pollution results in increased abundance of Particulate Matter] which results in increased expression of TXNIP protein] CTD PMID:37987454 NCBI chr 2:186,781,933...186,785,736
Ensembl chr 2:184,092,991...184,096,886 		JBrowse link
G Txnrd1 thioredoxin reductase 1 decreases expression ISO andrographolide results in decreased expression of TXNRD1 mRNA CTD PMID:35724838 NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 multiple interactions
increases expression		 ISO [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of UGT1A6 mRNA
andrographolide results in increased expression of UGT1A6 mRNA		 CTD PMID:19737545 NCBI chr 9:96,195,018...96,256,264
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions
increases expression		 ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of VCAM1 mRNA
andrographolide results in increased expression of VCAM1 mRNA		 CTD PMID:19737545 PMID:35724838 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression		 ISO [andrographolide co-treated with KDR protein] inhibits the reaction [VEGFA protein binds to KDR protein]; andrographolide inhibits the reaction [HIF1A protein binds to VEGFA promoter]; andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein]; andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAP2K4 protein]; andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAP2K6 protein]; andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAP2K7 protein]; andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAP3K5 protein]; andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK1 protein]; andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK3 protein]; andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of RAF1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [andrographolide results in decreased expression of VEGFA mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [andrographolide results in decreased expression of VEGFA protein]; EGLN1 mutant form inhibits the reaction [andrographolide results in decreased expression of VEGFA protein]; pyrazolanthrone inhibits the reaction [andrographolide results in decreased expression of VEGFA mRNA]; pyrazolanthrone inhibits the reaction [andrographolide results in decreased expression of VEGFA protein]
andrographolide results in decreased expression of VEGFA mRNA; andrographolide results in decreased expression of VEGFA protein		 CTD PMID:21134392 PMID:24814888 PMID:28651835 PMID:35724838 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vil1 villin 1 multiple interactions ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of VIL1 mRNA CTD PMID:19737545 NCBI chr 9:83,440,248...83,467,963
Ensembl chr 9:75,991,141...76,018,858 		JBrowse link
G Vim vimentin multiple interactions
decreases expression		 ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of VIM mRNA; andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of VIM protein]
andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of VIM protein]; IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of VIM protein]]
andrographolide results in decreased expression of VIM protein		 CTD PMID:19737545 PMID:31128153 PMID:35917943 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO andrographolide results in decreased expression of XIAP protein CTD PMID:23845849 NCBI chr  X:125,756,107...125,803,979
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
G Zfand2a zinc finger AN1-type containing 2A decreases expression ISO andrographolide results in decreased expression of ZFAND2A mRNA CTD PMID:35724838 NCBI chr12:20,275,435...20,286,513
Ensembl chr12:15,161,639...15,172,677 		JBrowse link
G Zg16b zymogen granule protein 16B multiple interactions
decreases expression		 ISO [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of SBPL mRNA
andrographolide results in decreased expression of SBPL mRNA		 CTD PMID:19737545 NCBI chr10:12,970,888...12,984,170
Ensembl chr10:12,979,020...12,983,572 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19887
    role 19858
      biological role 19856
        biochemical role 19566
          metabolite 19554
            andrographolide 172
Path 2
Term Annotations click to browse term
  CHEBI ontology 19887
    subatomic particle 19885
      composite particle 19885
        hadron 19885
          baryon 19885
            nucleon 19885
              atomic nucleus 19885
                atom 19885
                  main group element atom 19824
                    main group molecular entity 19824
                      s-block molecular entity 19658
                        hydrogen molecular entity 19640
                          hydrides 19145
                            organic hydride 18698
                              organic fundamental parent 18698
                                hydrocarbon 18446
                                  terpene 14074
                                    terpenoid 13774
                                      diterpenoid 13037
                                        labdane diterpenoid 193
                                          andrographolide 172
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