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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Lorazepam
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Accession:CHEBI:6539 term browser browse the term
Synonyms:related_synonym: Formula=C15H10Cl2N2O2;   InChI=1S/C15H10Cl2N2O2/c16-8-5-6-12-10(7-8)13(19-15(21)14(20)18-12)9-3-1-2-4-11(9)17/h1-7,15,21H,(H,18,20);   InChIKey=DIWRORZWFLOCLC-UHFFFAOYSA-N;   SMILES=C1=CC=C(C(=C1)C2=NC(C(=O)NC3=C2C=C(C=C3)Cl)O)Cl;   Wy 4036;   ativan
 alt_id: CHEBI:94326
 xref: CAS:846-49-1;   Drug_Central:1606;   HMDB:HMDB0014332;   KEGG:D00365;   LINCS:LSM-4970
 xref_mesh: MESH:D008140


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Lorazepam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 decreases expression EXP Lorazepam results in decreased expression of GABRA1 mRNA CTD PMID:16107249 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864 		JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 affects expression EXP Lorazepam affects the expression of GABRA2 mRNA CTD PMID:16107249 NCBI chr14:37,097,251...37,230,030
Ensembl chr14:37,097,279...37,228,944 		JBrowse link
G Gabra3 gamma-aminobutyric acid type A receptor subunit alpha 3 increases expression EXP Lorazepam results in increased expression of GABRA3 mRNA CTD PMID:16107249 NCBI chr  X:150,244,745...150,501,566
Ensembl chr  X:150,261,607...150,501,559 		JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 affects expression
affects response to substance		 EXP Lorazepam affects the expression of GABRA4 mRNA
GABRA4 protein affects the susceptibility to Lorazepam		 CTD PMID:12522171 PMID:16107249 NCBI chr14:36,590,782...36,667,724
Ensembl chr14:36,590,782...36,665,844 		JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 decreases expression EXP Lorazepam results in decreased expression of GABRG2 mRNA alternative form CTD PMID:16107249 NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19932
    role 19904
      biological role 19902
        biophysical role 14077
          membrane transport modulator 13914
            GABA modulator 5122
              benzodiazepine 924
                Lorazepam 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19932
    subatomic particle 19930
      composite particle 19930
        hadron 19930
          baryon 19930
            nucleon 19930
              atomic nucleus 19930
                atom 19930
                  main group element atom 19876
                    p-block element atom 19876
                      carbon group element atom 19816
                        carbon atom 19812
                          organic molecular entity 19812
                            organic molecule 19764
                              organic cyclic compound 19553
                                organic heterocyclic compound 18905
                                  organonitrogen heterocyclic compound 18179
                                    benzodiazepine 924
                                      Lorazepam 5
paths to the root