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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:loratadine
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Accession:CHEBI:6538 term browser browse the term
Definition:A benzocycloheptapyridine that is 6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine substituted by a chloro group at position 8 and a 1-(ethoxycarbonyl)piperidin-4-ylidene group at position 11. It is a H1-receptor antagonist commonly employed in the treatment of allergic disorders.
Synonyms:exact_synonym: ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate
 related_synonym: 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic acid ethyl ester;   Aerotina;   Alarin;   Alavert;   Alerpriv;   Allerclear;   Civeran;   Claratyne;   Formula=C22H23ClN2O2;   InChI=1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3;   InChIKey=JCCNYMKQOSZNPW-UHFFFAOYSA-N;   Loradamed;   Lorastine;   SMILES=CCOC(=O)N1CCC(CC1)=C1C2=C(CCC3=C1N=CC=C3)C=C(Cl)C=C2;   Wal-itin;   claritin;   loracert;   loradex;   loratadina;   loratadinum;   loratyne
 alt_id: CHEBI:94763
 xref: CAS:79794-75-5;   Chemspider:3820;   DrugBank:DB00455;   Drug_Central:1605;   FooDB:FDB023577;   HMDB:HMDB0005000;   KEGG:D00364;   LINCS:LSM-5891
 xref_mesh: MESH:D017336
 xref: PMID:15627436;   PMID:24134630;   PMID:31315424;   PMID:31576110;   PMID:32312261;   PMID:32694422;   PMID:32877950;   PMID:33550204;   PMID:33673552;   PMID:33963858;   PMID:34121623;   PMID:34306392;   PMID:7522069;   Reaxys:4273483;   Wikipedia:Loratadine



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loratadine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions
ISO Loratadine results in decreased activity of ABCB11 protein
Loratadine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
CTD PMID:23956101 PMID:24014644 PMID:28437613 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects response to substance
increases export
ISO ABCB1A protein affects the susceptibility to Loratadine
ABCB1 protein results in increased export of Loratadine
CTD PMID:12584158 PMID:15502009 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B affects response to substance ISO ABCB1B protein affects the susceptibility to Loratadine CTD PMID:15502009 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Loratadine results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 decreases response to substance ISO ABCC1 protein results in decreased susceptibility to Loratadine CTD PMID:22095822 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO Loratadine inhibits the reaction [ABCC2 protein results in increased export of Fosinopril] CTD PMID:22095822 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Ace2 angiotensin I converting enzyme 2 affects binding ISO Loratadine binds to ACE2 protein CTD PMID:33609497 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Alox5 arachidonate 5-lipoxygenase decreases activity ISO Loratadine analog results in decreased activity of ALOX5 protein CTD PMID:15482930 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
JBrowse link
G Ap1s1 adaptor related protein complex 1 subunit sigma 1 decreases expression ISO Loratadine results in decreased expression of AP1S1 mRNA CTD PMID:17567588 NCBI chr12:19,625,267...19,635,792
Ensembl chr12:19,625,332...19,756,713
JBrowse link
G Ar androgen receptor increases expression ISO Loratadine results in increased expression of AR mRNA CTD PMID:16407038 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Loratadine results in increased expression of ASNS mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
JBrowse link
G Casp3 caspase 3 increases cleavage
increases activity
multiple interactions
ISO Loratadine results in increased cleavage of CASP3 protein
Loratadine results in increased activity of CASP3 protein
Dasatinib promotes the reaction [Loratadine results in increased activity of CASP3 protein]; midostaurin promotes the reaction [Loratadine results in increased activity of CASP3 protein]; Palmitic Acid promotes the reaction [Loratadine results in increased activity of CASP3 protein]
CTD PMID:20570632 PMID:22700542 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions
ISO Loratadine results in increased activity of CASP7 protein
Palmitic Acid promotes the reaction [Loratadine results in increased activity of CASP7 protein]
CTD PMID:22700542 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 increases cleavage ISO Loratadine results in increased cleavage of CASP8 protein CTD PMID:20570632 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases cleavage ISO Loratadine results in increased cleavage of CASP9 protein CTD PMID:20570632 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Loratadine results in decreased activity of CYP2C8 protein CTD PMID:15601807
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects metabolic processing ISO CYP2D6 gene polymorphism affects the metabolism of Loratadine; CYP2D6 protein affects the metabolism of Loratadine CTD PMID:15932952 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO Loratadine analog results in decreased activity of CYP3A4 protein; Loratadine results in decreased activity of CYP3A4 protein CTD PMID:15482930 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Esr1 estrogen receptor 1 increases expression ISO Loratadine results in increased expression of ESR1 mRNA CTD PMID:16407038 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO Loratadine results in increased expression of FABP1 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
JBrowse link
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 increases expression ISO Loratadine results in increased expression of GDPD3 mRNA CTD PMID:15342952 NCBI chr 1:181,373,505...181,383,063
Ensembl chr 1:181,366,626...181,383,063
JBrowse link
G Hpn hepsin increases expression ISO Loratadine results in increased expression of HPN mRNA CTD PMID:15342952 NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811
JBrowse link
G Hrh1 histamine receptor H 1 affects binding ISO Loratadine analog binds to HRH1 protein; Loratadine binds to HRH1 protein CTD PMID:15482930 NCBI chr 4:147,564,781...147,649,353
Ensembl chr 4:147,645,995...147,647,455
JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Loratadine results in increased expression of INHBE mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 7:63,177,558...63,178,983
Ensembl chr 7:63,176,219...63,179,172
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity
multiple interactions
affects activity
ISO Loratadine results in decreased activity of KCNH2 protein
[desloratadine co-treated with Loratadine] results in decreased activity of KCNH2 protein; [Ketoconazole co-treated with desloratadine co-treated with Loratadine] results in decreased activity of KCNH2 protein; [Ketoconazole co-treated with Loratadine] results in decreased activity of KCNH2 protein; Loratadine binds to and results in decreased activity of KCNH2 protein; Loratadine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Loratadine affects the activity of KCNH2 protein
CTD PMID:9658196 PMID:10604956 PMID:11705456 PMID:16278312 PMID:21158687 More... NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Lss lanosterol synthase increases expression ISO Loratadine results in increased expression of LSS mRNA CTD PMID:15342952 NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Loratadine results in increased expression of NR0B2 mRNA CTD PMID:15342952 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Loratadine results in increased expression of NUPR1 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 1:181,213,292...181,215,327 JBrowse link
G Rps6 ribosomal protein S6 decreases expression ISO Loratadine results in decreased expression of RPS6 protein modified form CTD PMID:20570632 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602
JBrowse link
G Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N increases expression ISO Loratadine results in increased expression of SERPINA3 mRNA CTD PMID:15342952 NCBI chr 6:123,323,632...123,331,166
Ensembl chr 6:123,323,629...123,332,433
JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression ISO Loratadine results in decreased expression of SLC2A3 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Loratadine results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
JBrowse link
G Tagln transgelin decreases expression ISO Loratadine results in decreased expression of TAGLN mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668
JBrowse link

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  CHEBI ontology 20056
    role 20008
      application 19745
        pharmaceutical 19618
          drug 19618
            anti-allergic agent 3916
              loratadine 33
Path 2
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  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19875
                          organic molecular entity 19875
                            organic group 18961
                              organic divalent group 18947
                                organodiyl group 18947
                                  carbonyl group 18900
                                    carbonyl compound 18900
                                      carboxylic acid 18594
                                        carboacyl group 17706
                                          univalent carboacyl group 17706
                                            carbamoyl group 17546
                                              carboxamide 17546
                                                tertiary carboxamide 212
                                                  loratadine 33
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