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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ageladine A
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Accession:CHEBI:65373 term browser browse the term
Definition:An imidazopyridine that is 1H-imidazo[4,5-c]pyridin-2-amine substituted by a 4,5-dibromo-1H-pyrrol-2-yl group at position 4. It is an alkaloid isolated from a marine sponge Agelas nakamurai and acts as an inhibitor of the matrix metalloproteinases, the key enzymes involved in tumour growth, migration, angiogenesis, invasion and metastasis.
Synonyms:exact_synonym: 4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine
 related_synonym: Formula=C10H7Br2N5;   InChI=1S/C10H7Br2N5/c11-4-3-6(15-9(4)12)7-8-5(1-2-14-7)16-10(13)17-8/h1-3,15H,(H3,13,16,17);   InChIKey=QAKGJAQGTQLMFN-UHFFFAOYSA-N;   SMILES=Nc1nc2c(nccc2[nH]1)-c1cc(Br)c(Br)[nH]1
 xref_mesh: MESH:C482289
 xref: PMID:14677933;   PMID:16562912;   PMID:17261003;   PMID:19948404;   PMID:22363232;   Patent:WO2009152584;   Reaxys:9568941


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ageladine A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A decreases activity
multiple interactions		 EXP Ageladine A results in decreased activity of DYRK1A protein
Ageladine A analog binds to and results in decreased activity of DYRK1A protein		 CTD PMID:21413800 NCBI chr11:33,890,706...34,009,420
Ensembl chr11:33,890,490...34,009,420 		JBrowse link
G Mmp14 matrix metallopeptidase 14 decreases activity ISO Ageladine A results in decreased activity of MMP14 protein CTD PMID:21413800 NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases activity ISO Ageladine A results in decreased activity of MMP2 protein CTD PMID:21413800 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase decreases activity ISO Ageladine A results in decreased activity of PIM1 protein CTD PMID:21413800 NCBI chr20:7,554,921...7,559,174
Ensembl chr20:7,554,921...7,559,174 		JBrowse link
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Term Annotations click to browse term
  CHEBI ontology 19900
    role 19875
      biological role 19873
        biochemical role 19567
          metabolite 19552
            ageladine A 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19900
    subatomic particle 19898
      composite particle 19898
        hadron 19898
          baryon 19898
            nucleon 19898
              atomic nucleus 19898
                atom 19898
                  main group element atom 19845
                    p-block element atom 19845
                      carbon group element atom 19792
                        carbon atom 19787
                          organic molecular entity 19787
                            organic molecule 19744
                              organic cyclic compound 19549
                                organic heterocyclic compound 18888
                                  heteroarene 17153
                                    monocyclic heteroarene 14802
                                      azole 14287
                                        pyrroles 5927
                                          ageladine A 4
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