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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ageladine A
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Accession:CHEBI:65373 term browser browse the term
Definition:An imidazopyridine that is 1H-imidazo[4,5-c]pyridin-2-amine substituted by a 4,5-dibromo-1H-pyrrol-2-yl group at position 4. It is an alkaloid isolated from a marine sponge Agelas nakamurai and acts as an inhibitor of the matrix metalloproteinases, the key enzymes involved in tumour growth, migration, angiogenesis, invasion and metastasis.
Synonyms:exact_synonym: 4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine
 related_synonym: Formula=C10H7Br2N5;   InChI=1S/C10H7Br2N5/c11-4-3-6(15-9(4)12)7-8-5(1-2-14-7)16-10(13)17-8/h1-3,15H,(H3,13,16,17);   InChIKey=QAKGJAQGTQLMFN-UHFFFAOYSA-N;   SMILES=Nc1nc2c(nccc2[nH]1)-c1cc(Br)c(Br)[nH]1
 xref_mesh: MESH:C482289
 xref: PMID:14677933;   PMID:16562912;   PMID:17261003;   PMID:19948404;   PMID:22363232;   Patent:WO2009152584;   Reaxys:9568941

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ageladine A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A decreases activity
multiple interactions
EXP Ageladine A results in decreased activity of DYRK1A protein
Ageladine A analog binds to and results in decreased activity of DYRK1A protein
CTD PMID:21413800 NCBI chr11:33,890,706...34,009,420
Ensembl chr11:33,890,490...34,009,420
JBrowse link
G Mmp14 matrix metallopeptidase 14 decreases activity ISO Ageladine A results in decreased activity of MMP14 protein CTD PMID:21413800 NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases activity ISO Ageladine A results in decreased activity of MMP2 protein CTD PMID:21413800 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase decreases activity ISO Ageladine A results in decreased activity of PIM1 protein CTD PMID:21413800 NCBI chr20:7,554,921...7,559,174
Ensembl chr20:7,554,921...7,559,174
JBrowse link

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  CHEBI ontology 20089
    role 20042
      biological role 20011
        biochemical role 19671
          metabolite 19631
            ageladine A 4
Path 2
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  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic molecule 19856
                              organic cyclic compound 19612
                                organic heterocyclic compound 18824
                                  heteroarene 16628
                                    monocyclic heteroarene 13606
                                      azole 12836
                                        pyrroles 5910
                                          ageladine A 4
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