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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ageladine A
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Accession:CHEBI:65373 term browser browse the term
Definition:An imidazopyridine that is 1H-imidazo[4,5-c]pyridin-2-amine substituted by a 4,5-dibromo-1H-pyrrol-2-yl group at position 4. It is an alkaloid isolated from a marine sponge Agelas nakamurai and acts as an inhibitor of the matrix metalloproteinases, the key enzymes involved in tumour growth, migration, angiogenesis, invasion and metastasis.
Synonyms:exact_synonym: 4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine
 related_synonym: Formula=C10H7Br2N5;   InChI=1S/C10H7Br2N5/c11-4-3-6(15-9(4)12)7-8-5(1-2-14-7)16-10(13)17-8/h1-3,15H,(H3,13,16,17);   InChIKey=QAKGJAQGTQLMFN-UHFFFAOYSA-N;   SMILES=Nc1nc2c(nccc2[nH]1)-c1cc(Br)c(Br)[nH]1
 xref_mesh: MESH:C482289
 xref: PMID:14677933;   PMID:16562912;   PMID:17261003;   PMID:19948404;   PMID:22363232;   Patent:WO2009152584;   Reaxys:9568941

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ageladine A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A decreases activity
multiple interactions
EXP Ageladine A results in decreased activity of DYRK1A protein
Ageladine A analog binds to and results in decreased activity of DYRK1A protein
CTD PMID:21413800 NCBI chr11:33,890,706...34,009,420
Ensembl chr11:33,890,490...34,009,420
JBrowse link
G Mmp14 matrix metallopeptidase 14 decreases activity ISO Ageladine A results in decreased activity of MMP14 protein CTD PMID:21413800 NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases activity ISO Ageladine A results in decreased activity of MMP2 protein CTD PMID:21413800 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase decreases activity ISO Ageladine A results in decreased activity of PIM1 protein CTD PMID:21413800 NCBI chr20:7,554,921...7,559,174
Ensembl chr20:7,554,921...7,559,174
JBrowse link

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  CHEBI ontology 19821
    role 19769
      biological role 19769
        biochemical role 19389
          metabolite 19364
            ageladine A 4
Path 2
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  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic molecule 19569
                              organic cyclic compound 19360
                                organic heterocyclic compound 18591
                                  heteroarene 16530
                                    monocyclic heteroarene 13437
                                      azole 12628
                                        pyrroles 5887
                                          ageladine A 4
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