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ONTOLOGY REPORT - ANNOTATIONS


Term:carfilzomib
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Accession:CHEBI:65347 term browser browse the term
Definition:A synthetic tetrapeptide consisting of morpholin-4-acetyl, L-2-amino-4-phenylbutanoyl, L-leucyl and L-phenylalanyl residues joined in sequence with the C-terminus connected to the amino group of (2S)-2-amino-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-1-one via an amide linkage. Used for the treatment of patients with multiple myeloma
Synonyms:exact_synonym: N-{(2S)-2-[(morpholin-4-ylacetyl)amino]-4-phenylbutanoyl}-L-leucyl-N-{(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl}-L-phenylalaninamide
 related_synonym: Formula=C40H57N5O7;   InChI=1S/C40H57N5O7/c1-27(2)22-32(36(47)40(5)26-52-40)42-39(50)34(24-30-14-10-7-11-15-30)44-38(49)33(23-28(3)4)43-37(48)31(17-16-29-12-8-6-9-13-29)41-35(46)25-45-18-20-51-21-19-45/h6-15,27-28,31-34H,16-26H2,1-5H3,(H,41,46)(H,42,50)(H,43,48)(H,44,49)/t31-,32-,33-,34-,40+/m0/s1;   InChIKey=BLMPQMFVWMYDKT-NZTKNTHTSA-N;   Kyprolis;   SMILES=C(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C([C@@]1(OC1)C)=O)CC(C)C)=O)CC2=CC=CC=C2)=O)CC(C)C)=O)CCC3=CC=CC=C3)=O)N4CCOCC4
 xref: CAS:868540-17-4 "ChemIDplus";   CAS:868540-17-4 "KEGG DRUG";   Drug_Central:4483 "DrugCentral";   KEGG:D08880
 xref_mesh: MESH:C524865
 xref: PMID:19348473 "Europe PMC";   PMID:20937826 "Europe PMC";   PMID:21905015 "Europe PMC";   PMID:22235146 "Europe PMC";   PMID:22411899 "Europe PMC";   PMID:22507794 "Europe PMC";   PMID:22507799 "Europe PMC";   PMID:22555973 "Europe PMC";   PMID:22621161 "Europe PMC";   PMID:22645181 "Europe PMC";   PMID:22665938 "Europe PMC";   PMID:22726549 "Europe PMC";   PMID:22727391 "Europe PMC";   PMID:22734651 "Europe PMC";   PMID:22761464 "Europe PMC";   PMID:22763387 "Europe PMC";   Reaxys:12488950 "Reaxys";   Wikipedia:Carfilzomib


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carfilzomib term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Afp alpha-fetoprotein JBrowse link 14 19,141,755 19,159,919 RGD:6480464
G Brca1 BRCA1, DNA repair associated JBrowse link 10 89,394,821 89,455,093 RGD:6480464
G Brd4 bromodomain containing 4 JBrowse link 7 14,222,101 14,303,055 RGD:6480464
G Gpt glutamic--pyruvic transaminase JBrowse link 7 117,759,083 117,761,932 RGD:6480464
G Mmp2 matrix metallopeptidase 2 JBrowse link 19 15,542,771 15,570,589 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Prkcsh protein kinase C substrate 80K-H JBrowse link 8 23,014,802 23,026,507 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Timp1 TIMP metallopeptidase inhibitor 1 JBrowse link X 1,364,771 1,369,451 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19662
    role 19606
      application 19232
        pharmaceutical 19094
          drug 19094
            antineoplastic agent 16568
              carfilzomib 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19662
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19658
                atom 19658
                  main group element atom 19539
                    p-block element atom 19539
                      carbon group element atom 19422
                        carbon atom 19414
                          organic molecular entity 19414
                            organic group 18340
                              organic divalent group 18330
                                organodiyl group 18330
                                  carbonyl group 18217
                                    carbonyl compound 18217
                                      carboxylic acid 17921
                                        carboacyl group 16944
                                          univalent carboacyl group 16944
                                            carbamoyl group 16623
                                              carboxamide 16623
                                                peptide 9295
                                                  oligopeptide 1073
                                                    tetrapeptide 12
                                                      carfilzomib 10
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.