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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:PX-866
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Accession:CHEBI:65345 term browser browse the term
Definition:An organic heterotetracyclic compound that is obtained from wortmanin via aminolysis of its furan ring by diallyl amine.
Synonyms:exact_synonym: (1E,4S,4aR,5R,6aS,9aR)-1-{[di(prop-2-en-1-yl)amino]methylidene}-11-hydroxy-4-(methoxymethyl)-4a,6a-dimethyl-2,7,10-trioxo-1,2,4,4a,5,6,6a,7,8,9,9a,10-dodecahydroindeno[4,5-h]isochromen-5-yl acetate
 related_synonym: Formula=C29H35NO8;   InChI=1S/C29H35NO8/c1-7-11-30(12-8-2)14-17-23-26(34)25(33)22-18-9-10-20(32)28(18,4)13-19(37-16(3)31)24(22)29(23,5)21(15-36-6)38-27(17)35/h7-8,14,18-19,21,34H,1-2,9-13,15H2,3-6H3/b17-14+/t18-,19+,21+,28-,29-/m0/s1;   InChIKey=QIUASFSNWYMDFS-NILGECQDSA-N;   SMILES=[H][C@@]12CCC(=O)[C@@]1(C)C[C@@H](OC(C)=O)C1=C2C(=O)C(O)=C2\\C(=C/N(CC=C)CC=C)C(=O)O[C@H](COC)[C@]12C
 xref_mesh: MESH:C496788
 xref: Reaxys:12534000


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PX-866 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
ISO PX-866 results in decreased phosphorylation of AKT1 protein
PX-866 inhibits the reaction [[Calcium co-treated with Ionomycin] results in increased phosphorylation of AKT1 protein]; PX-866 promotes the reaction [STO 609 results in decreased phosphorylation of AKT1 protein]; STO 609 promotes the reaction [PX-866 results in decreased phosphorylation of AKT1 protein]
CTD PMID:25805502 PMID:28634229 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bad BCL2-associated agonist of cell death decreases phosphorylation
multiple interactions
ISO PX-866 results in decreased phosphorylation of BAD protein
[PX-866 co-treated with BBR3610] results in decreased phosphorylation of BAD protein
CTD PMID:20473884 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2 affects response to substance ISO CAMKK2 protein affects the susceptibility to PX-866 CTD PMID:28634229 NCBI chr12:33,791,023...33,845,000
Ensembl chr12:33,791,052...33,843,279
JBrowse link
G Cd36 CD36 molecule multiple interactions ISO [PX-866 co-treated with SORT1 protein] results in decreased expression of CD36 mRNA CTD PMID:25805502 NCBI chr 4:17,317,343...17,410,084 JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions ISO [PX-866 co-treated with SORT1 protein] results in decreased expression of CYP7A1 mRNA CTD PMID:25805502 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO PX-866 promotes the reaction [SORT1 protein results in decreased expression of FASN mRNA] CTD PMID:25805502 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Mttp microsomal triglyceride transfer protein multiple interactions ISO PX-866 promotes the reaction [SORT1 protein results in decreased expression of MTTP mRNA] CTD PMID:25805502 NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239
JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO PX-866 promotes the reaction [SORT1 protein results in decreased expression of SCD1 mRNA] CTD PMID:25805502 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Sort1 sortilin 1 multiple interactions
decreases expression
ISO [PX-866 co-treated with SORT1 protein] results in decreased expression of CD36 mRNA; [PX-866 co-treated with SORT1 protein] results in decreased expression of CYP7A1 mRNA; PX-866 promotes the reaction [SORT1 protein results in decreased expression of FASN mRNA]; PX-866 promotes the reaction [SORT1 protein results in decreased expression of MTTP mRNA]; PX-866 promotes the reaction [SORT1 protein results in decreased expression of SCD1 mRNA]; SORT1 protein inhibits the reaction [PX-866 results in increased abundance of Triglycerides]
PX-866 results in decreased expression of SORT1 protein
CTD PMID:25805502 NCBI chr 2:195,924,033...196,002,354
Ensembl chr 2:195,924,099...196,002,354
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      application 19481
        food additive 15108
          food acidity regulator 11724
            acetic acid 10853
              acetate ester 3873
                PX-866 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic acid 18373
                                        monocarboxylic acid 17636
                                          acetic acid 10853
                                            acetate ester 3873
                                              wortmannin 266
                                                PX-866 9
paths to the root