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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:triciribine
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Accession:CHEBI:65310 term browser browse the term
Definition:A nucleoside analogue in which the nucleobase portion is a 1,4,5,6,8-pentaazaacenaphthylene ring system substituted with an amino group at position 3, and a methyl group at position 5 and is bound to the beta-D-ribofuranosyl moiety by an N(1)-glycosidic linkage.
Synonyms:exact_synonym: 5-methyl-1-(beta-D-ribofuranosyl)-1,5-dihydro-1,4,5,6,8-pentaazaacenaphthylen-3-amine
 related_synonym: Formula=C13H16N6O4;   InChI=1S/C13H16N6O4/c1-18-11-7-5(10(14)17-18)2-19(12(7)16-4-15-11)13-9(22)8(21)6(3-20)23-13/h2,4,6,8-9,13,20-22H,3H2,1H3,(H2,14,17)/t6-,8-,9-,13-/m1/s1;   InChIKey=HOGVTUZUJGHKPL-HTVVRFAVSA-N;   SMILES=Cn1nc(N)c2cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c3ncnc1c23;   TCN
 xref: CAS:35943-35-2;   LINCS:LSM-3810
 xref_mesh: MESH:C023764
 xref: PMID:22075556;   PMID:22728437;   PMID:22773664;   Reaxys:1171593


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triciribine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO triciribine results in decreased phosphorylation of AKT1 protein CTD PMID:20857426 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Akt2 AKT serine/threonine kinase 2 decreases phosphorylation ISO triciribine results in decreased phosphorylation of AKT2 protein CTD PMID:20857426 NCBI chr 1:84,400,939...84,451,223
Ensembl chr 1:84,411,726...84,450,162
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO triciribine inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [Nitroprusside affects the localization of BAX protein]] CTD PMID:22178905 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
ISO triciribine promotes the reaction [[epothilone A co-treated with Metformin] results in increased expression of CASP3 mRNA]
triciribine results in increased expression of CASP3 mRNA
CTD PMID:29117515 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO triciribine inhibits the reaction [1-nitropyrene results in increased stability of CYP1A1 mRNA] CTD PMID:19961161 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Fshb follicle stimulating hormone subunit beta decreases activity ISO triciribine results in decreased activity of FSHB protein CTD PMID:23254195 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G H2ax H2A.X variant histone increases expression ISO triciribine results in increased expression of H2AX mRNA CTD PMID:29117515 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO triciribine inhibits the reaction [HRAS protein results in increased activity of MMP2 protein] CTD PMID:23877152 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
JBrowse link
G Ins2 insulin 2 multiple interactions ISO triciribine inhibits the reaction [INS protein results in decreased susceptibility to sodium arsenite] CTD PMID:25982963 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO triciribine inhibits the reaction [HRAS protein results in increased activity of MMP2 protein] CTD PMID:23877152 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP triciribine inhibits the reaction [Mevinphos results in increased expression of NOS2 protein] CTD PMID:24462917 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases expression
ISO triciribine inhibits the reaction [epothilone A results in increased expression of PARP1 mRNA]; triciribine promotes the reaction [[epothilone A co-treated with Metformin] results in increased expression of PARP1 mRNA]
triciribine results in increased expression of PARP1 mRNA
CTD PMID:29117515 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Phb prohibitin increases expression EXP triciribine results in increased expression of PHB protein CTD PMID:23254195 NCBI chr10:83,476,107...83,488,878
Ensembl chr10:83,476,107...83,488,878
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP triciribine inhibits the reaction [Mevinphos results in increased activity of RELA protein] CTD PMID:24462917 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19761
    role 19711
      biological role 19711
        inhibitor 18295
          enzyme inhibitor 18224
            EC 2.* (transferase) inhibitor 13866
              EC 2.7.* (P-containing group transferase) inhibitor 13538
                lipid kinase inhibitor 969
                  EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor 822
                    triciribine 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19761
    subatomic particle 19759
      composite particle 19759
        hadron 19759
          baryon 19759
            nucleon 19759
              atomic nucleus 19759
                atom 19759
                  main group element atom 19653
                    p-block element atom 19653
                      carbon group element atom 19569
                        carbon atom 19559
                          organic molecular entity 19559
                            heteroorganic entity 19195
                              organochalcogen compound 18941
                                organooxygen compound 18868
                                  carbohydrates and carbohydrate derivatives 12260
                                    carbohydrate 12260
                                      carbohydrate derivative 11888
                                        glycosyl compound 10962
                                          N-glycosyl compound 5484
                                            nucleoside analogue 710
                                              triciribine 14
paths to the root