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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:lomustine
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Accession:CHEBI:6520 term browser browse the term
Definition:An N-nitrosourea that is urea in which one of the nitrogens is substituted by a 2-chloroethyl group and by a nitroso group, while the other nitrogen is substituted by a cyclohexyl group. An alkylating antineoplastic agent, it is used in the treatment of brain tumours, lung cancer, malignant melanoma and other solid tumours.
Synonyms:related_synonym: 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea;   1-(2-chloroethyl)-3-cyclohexylnitrosourea;   Belustine;   CCNU;   CINU;   Cecenu;   CeeNU;   Formula=C9H16ClN3O2;   InChI=1S/C9H16ClN3O2/c10-6-7-13(12-15)9(14)11-8-4-2-1-3-5-8/h8H,1-7H2,(H,11,14);   InChIKey=GQYIWUVLTXOXAJ-UHFFFAOYSA-N;   N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea;   SMILES=ClCCN(N=O)C(=O)NC1CCCCC1;   chloroethylcyclohexylnitrosourea;   cyclohexyl chloroethyl nitrosourea;   lomustina;   lomustinum
 xref: CAS:13010-47-4;   DrugBank:DB01206;   Drug_Central:1596;   HMDB:HMDB0015337;   KEGG:C07079;   KEGG:D00363
 xref_mesh: MESH:D008130
 xref: PMID:12153595;   PMID:19901016;   PMID:20719460;   PMID:22577051;   PMID:24293673;   PMID:24368412;   PMID:24516018;   PMID:6762924;   Reaxys:2125058;   Wikipedia:Lomustine


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lomustine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO Lomustine results in increased expression of ABCB1 protein CTD PMID:15239124 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Ace2 angiotensin I converting enzyme 2 decreases expression ISO Lomustine results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Lomustine results in increased expression of CDKN1A mRNA; Lomustine results in increased expression of CDKN1A protein CTD PMID:24211769 PMID:27358234 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Lomustine results in increased expression of DDIT3 protein CTD PMID:27358234 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Ina internexin neuronal intermediate filament protein, alpha multiple interactions ISO INA affects the susceptibility to [Procarbazine co-treated with Lomustine co-treated with Vincristine] CTD PMID:21246521 NCBI chr 1:245,896,775...245,908,330
Ensembl chr 1:245,896,775...245,908,330
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase multiple interactions
decreases response to substance
ISO MGMT protein affects the susceptibility to [Procarbazine co-treated with Lomustine co-treated with Vincristine]
MGMT mRNA results in decreased susceptibility to Lomustine
CTD PMID:15448748 PMID:16033832 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
JBrowse link
G Polh DNA polymerase eta increases expression
decreases response to substance
multiple interactions
ISO Lomustine results in increased expression of POLH mRNA; Lomustine results in increased expression of POLH protein
POLH protein results in decreased susceptibility to Lomustine
pifithrin inhibits the reaction [Lomustine results in increased expression of POLH protein]
CTD PMID:25125662 NCBI chr 9:14,778,355...14,813,210
Ensembl chr 9:14,777,888...14,812,723
JBrowse link
G Socs1 suppressor of cytokine signaling 1 decreases expression ISO Lomustine results in decreased expression of SOCS1 mRNA CTD PMID:17374387 NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Lomustine results in increased expression of SRXN1 protein CTD PMID:27358234 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
JBrowse link
G Stmn1 stathmin 1 affects response to substance ISO STMN1 mRNA affects the susceptibility to Lomustine CTD PMID:17440165 NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      application 19471
        pharmaceutical 19319
          drug 19319
            antineoplastic agent 17316
              lomustine 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic acid 18364
                                        carboacyl group 17482
                                          univalent carboacyl group 17482
                                            carbamoyl group 17298
                                              carboxamide 17298
                                                monocarboxylic acid amide 15014
                                                  urea 5112
                                                    ureas 5109
                                                      N-nitrosoureas 2044
                                                        lomustine 10
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