CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: first generation antipsychotic
Accession: CHEBI:65190
browse the term
Definition: Antipsychotic drugs which can have different modes of action but which tend to be more likely than second generation antipsychotics to cause extrapyramidal motor control disabilities such as body rigidity or Parkinson's disease-type movements; such body movements can become permanent even after treatment has ceased.
Synonyms: related_synonym: first generation antipsychotic agent; first generation antipsychotic agents; first generation antipsychotic drug; first generation antipsychotic drugs; first generation antipsychotics; typical antipsychotic; typical antipsychotic agent; typical antipsychotic agents; typical antipsychotic drug; typical antipsychotic drugs; typical antipsychotics
xref: Wikipedia:Typical_antipsychotic
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Htr1a
5-hydroxytryptamine receptor 1A
multiple interactions
ISO
Chlorprothixene inhibits the reaction [(2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane binds to HTR1A protein]
CTD
PMID:2891550
NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442
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Kcnh2
potassium voltage-gated channel subfamily H member 2
decreases activity
ISO
Chlorprothixene results in decreased activity of KCNH2 protein
CTD
PMID:28551711
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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Prl
prolactin
increases secretion
ISO
Chlorprothixene results in increased secretion of PRL protein
CTD
PMID:10525070
NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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Ache
acetylcholinesterase
increases activity
ISO
Acepromazine results in increased activity of ACHE protein
CTD
PMID:29614332
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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Ar
androgen receptor
multiple interactions
ISO
acetophenazine binds to and results in decreased activity of AR protein
CTD
PMID:17606915
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Abcb11
ATP binding cassette subfamily B member 11
multiple interactions decreases expression
ISO EXP
[Chlorpromazine co-treated with Cholic Acids] affects the expression of ABCB11 mRNA Chlorpromazine results in decreased expression of ABCB11 mRNA; Chlorpromazine results in decreased expression of ABCB11 protein
CTD
PMID:27344345 PMID:27765674 PMID:28391356 PMID:35708773
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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Abcb1a
ATP binding cassette subfamily B member 1A
increases expression decreases activity
ISO
Chlorpromazine analog results in increased expression of ABCB1 mRNA Chlorpromazine results in decreased activity of ABCB1 protein
CTD
PMID:15924885 PMID:16810505
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Abcb1b
ATP-binding cassette, sub-family B member 1B
affects activity
EXP
Chlorpromazine affects the activity of ABCB1B protein
CTD
PMID:12626638
NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
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Abcb4
ATP binding cassette subfamily B member 4
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of ABCB4 mRNA
CTD
PMID:27344345
NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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Abcb6
ATP binding cassette subfamily B member 6
decreases expression
EXP
Chlorpromazine results in decreased expression of ABCB6 mRNA
CTD
PMID:25596134
NCBI chr 9:76,668,554...76,677,263
Ensembl chr 9:76,668,554...76,676,924
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Abcb9
ATP binding cassette subfamily B member 9
increases expression
EXP
Chlorpromazine results in increased expression of ABCB9 mRNA
CTD
PMID:25596134
NCBI chr12:32,499,213...32,531,932
Ensembl chr12:32,499,225...32,531,931
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Abcc2
ATP binding cassette subfamily C member 2
increases expression multiple interactions
EXP ISO
Chlorpromazine results in increased expression of ABCC2 mRNA [Bile Acids and Salts co-treated with Chlorpromazine] results in decreased expression of ABCC2 mRNA
CTD
PMID:27765674 PMID:35708773
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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Abcc3
ATP binding cassette subfamily C member 3
increases expression multiple interactions decreases expression
ISO EXP
Chlorpromazine analog results in increased expression of ABCC3 mRNA [Bile Acids and Salts co-treated with Chlorpromazine] results in decreased expression of ABCC3 mRNA Chlorpromazine results in decreased expression of ABCC3 mRNA
CTD
PMID:15924885 PMID:25596134 PMID:35708773
NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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Abcc4
ATP binding cassette subfamily C member 4
increases expression
ISO
Chlorpromazine results in increased expression of ABCC4 mRNA
CTD
PMID:35708773
NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
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Abcg2
ATP binding cassette subfamily G member 2
multiple interactions
ISO
Chlorpromazine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]
CTD
PMID:18834354
NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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Abcg8
ATP binding cassette subfamily G member 8
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of ABCG8 mRNA
CTD
PMID:27344345
NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912
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Acaca
acetyl-CoA carboxylase alpha
decreases phosphorylation
EXP
Chlorpromazine results in decreased phosphorylation of ACACA protein
CTD
PMID:17512020
NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
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Ace2
angiotensin converting enzyme 2
decreases expression
ISO
Chlorpromazine results in decreased expression of ACE2 mRNA
CTD
PMID:32808185
NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
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Ache
acetylcholinesterase
decreases activity increases activity multiple interactions
ISO
Chlorpromazine results in decreased activity of ACHE protein Chlorpromazine results in increased activity of ACHE protein Dichlorvos promotes the reaction [Chlorpromazine results in decreased activity of ACHE protein]
CTD
PMID:4859365 PMID:29614332
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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Acp5
acid phosphatase 5, tartrate resistant
multiple interactions
ISO
Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]
CTD
PMID:21869564
NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929
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Adra1a
adrenoceptor alpha 1A
decreases activity
EXP
Chlorpromazine results in decreased activity of ADRA1A protein
CTD
PMID:23611293
NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500
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Adra1b
adrenoceptor alpha 1B
decreases activity
EXP
Chlorpromazine results in decreased activity of ADRA1B protein
CTD
PMID:23611293
NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919
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Afp
alpha-fetoprotein
decreases expression
ISO
Chlorpromazine analog results in decreased expression of AFP mRNA
CTD
PMID:15924885
NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
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Agrn
agrin
decreases expression
EXP
Chlorpromazine results in decreased expression of AGRN mRNA
CTD
PMID:25596134
NCBI chr 5:166,749,306...166,782,212
Ensembl chr 5:166,749,310...166,786,003
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Ahr
aryl hydrocarbon receptor
affects activity
EXP
Chlorpromazine affects the activity of AHR protein
CTD
PMID:25596134
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Ak3
adenylate kinase 3
decreases expression
EXP
Chlorpromazine results in decreased expression of AK3 mRNA
CTD
PMID:25596134
NCBI chr 1:226,737,472...226,764,647
Ensembl chr 1:226,739,318...226,764,625
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Akt1
AKT serine/threonine kinase 1
decreases phosphorylation
EXP
Chlorpromazine results in decreased phosphorylation of AKT1 protein
CTD
PMID:17512020
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Aldh1a1
aldehyde dehydrogenase 1 family, member A1
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of ALDH1A1 mRNA
CTD
PMID:27344345
NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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Aldoa
aldolase, fructose-bisphosphate A
increases expression
EXP
Chlorpromazine results in increased expression of ALDOA mRNA
CTD
PMID:25596134
NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182
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Alpp
alkaline phosphatase, placental
multiple interactions
ISO
Chlorpromazine inhibits the reaction [Colforsin results in increased expression of ALPP mRNA]; Chlorpromazine inhibits the reaction [Isoproterenol results in increased expression of ALPP mRNA]
CTD
PMID:16036225
NCBI chr 9:87,765,846...87,768,606
Ensembl chr 9:87,765,860...87,768,606
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Ap1s1
adaptor related protein complex 1 subunit sigma 1
decreases expression
ISO
Chlorpromazine results in decreased expression of AP1S1 mRNA
CTD
PMID:17175557
NCBI chr12:19,625,267...19,635,792
Ensembl chr12:19,625,332...19,756,713
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Apoc4
apolipoprotein C4
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of APOC4 mRNA
CTD
PMID:27344345
NCBI chr 1:79,335,745...79,339,942
Ensembl chr 1:79,335,745...79,339,981
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Apof
apolipoprotein F
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of APOF mRNA
CTD
PMID:27344345
NCBI chr 7:700,688...702,130
Ensembl chr 7:700,762...701,946
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Areg
amphiregulin
decreases expression
ISO
Chlorpromazine results in decreased expression of AREG mRNA
CTD
PMID:15924885 PMID:30703373
NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535
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Arfgef2
ADP ribosylation factor guanine nucleotide exchange factor 2
increases expression
EXP
Chlorpromazine results in increased expression of ARFGEF2 mRNA
CTD
PMID:25596134
NCBI chr 3:155,547,504...155,633,652
Ensembl chr 3:155,547,538...155,630,856
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Arhgef10
Rho guanine nucleotide exchange factor 10
decreases expression
EXP
Chlorpromazine results in decreased expression of ARHGEF10 mRNA
CTD
PMID:25596134
NCBI chr16:74,647,147...74,738,784
Ensembl chr16:74,647,153...74,738,173
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Asah1
N-acylsphingosine amidohydrolase 1
increases expression
ISO
Chlorpromazine results in increased expression of ASAH1 mRNA
CTD
PMID:17175557
NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233
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Asns
asparagine synthetase (glutamine-hydrolyzing)
increases expression
ISO
Chlorpromazine results in increased expression of ASNS mRNA
CTD
PMID:17175557
NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
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Atf4
activating transcription factor 4
affects activity multiple interactions
EXP ISO
Chlorpromazine affects the activity of ATF4 protein [Chlorpromazine co-treated with Cholic Acids] affects the expression of ATF4 mRNA
CTD
PMID:25596134 PMID:27344345
NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
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Atp6v1b2
ATPase H+ transporting V1 subunit B2
decreases expression
EXP
Chlorpromazine results in decreased expression of ATP6V1B2 protein
CTD
PMID:19441803
NCBI chr16:20,617,515...20,641,651
Ensembl chr16:20,617,518...20,641,745
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Avp
arginine vasopressin
increases expression multiple interactions
ISO EXP
Chlorpromazine results in increased expression of AVP protein Chlorpromazine inhibits the reaction [Lithium results in increased expression of AVP protein]
CTD
PMID:3567260 PMID:3976404
NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
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Bag4
BAG cochaperone 4
decreases expression
ISO
Chlorpromazine analog results in decreased expression of BAG4 mRNA
CTD
PMID:15924885
NCBI chr16:66,288,678...66,305,893
Ensembl chr16:66,288,678...66,308,663
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Bcl2l1
Bcl2-like 1
increases expression
ISO
Chlorpromazine results in increased expression of BCL2L1 mRNA
CTD
PMID:21683644
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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Bdnf
brain-derived neurotrophic factor
affects response to substance affects expression
ISO EXP
BDNF affects the susceptibility to Chlorpromazine Chlorpromazine affects the expression of BDNF mRNA
CTD
PMID:18408624 PMID:31324950
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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Bhlhe40
basic helix-loop-helix family, member e40
increases expression
ISO
Chlorpromazine analog results in increased expression of BHLHE40 mRNA
CTD
PMID:15924885
NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774
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Birc2
baculoviral IAP repeat-containing 2
decreases expression
ISO
Chlorpromazine results in decreased expression of BIRC2 mRNA
CTD
PMID:30703373
NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
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Birc5
baculoviral IAP repeat-containing 5
decreases expression
ISO
Chlorpromazine analog results in decreased expression of BIRC5 mRNA; Chlorpromazine results in decreased expression of BIRC5 mRNA
CTD
PMID:15924885 PMID:30703373
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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Bnip3
BCL2 interacting protein 3
increases expression
EXP
Chlorpromazine results in increased expression of BNIP3 mRNA
CTD
PMID:25596134
NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
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Btg2
BTG anti-proliferation factor 2
increases expression
ISO
Chlorpromazine analog results in increased expression of BTG2 mRNA
CTD
PMID:15924885
NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
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Btg3
BTG anti-proliferation factor 3
increases expression
ISO
Chlorpromazine analog results in increased expression of BTG3 mRNA
CTD
PMID:15924885
NCBI chr11:17,030,156...17,046,069
Ensembl chr11:17,030,160...17,046,170
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C3
complement C3
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of C3 mRNA
CTD
PMID:27344345
NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
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C6
complement C6
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of C6 mRNA
CTD
PMID:27344345
NCBI chr 2:53,846,028...53,921,279
Ensembl chr 2:53,851,985...53,921,275
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Calcr
calcitonin receptor
multiple interactions
ISO
Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA]
CTD
PMID:21869564
NCBI chr 4:31,661,270...31,736,392
Ensembl chr 4:31,661,273...31,736,392
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Calr
calreticulin
decreases expression
EXP
Chlorpromazine results in decreased expression of CALR mRNA
CTD
PMID:18246545
NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414
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Car2
carbonic anhydrase 2
multiple interactions
ISO
Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of CAR2 mRNA]
CTD
PMID:21869564
NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
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Cat
catalase
multiple interactions decreases expression decreases activity
EXP ISO
carvedilol inhibits the reaction [Chlorpromazine results in decreased expression of CAT protein]; zolpidem inhibits the reaction [Chlorpromazine results in decreased activity of CAT]
CTD
PMID:12010767 PMID:17513028 PMID:25449126
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ccn2
cellular communication network factor 2
decreases expression
ISO
Chlorpromazine results in decreased expression of CCN2 mRNA; Chlorpromazine results in decreased expression of CCN2 protein
CTD
PMID:30703373
NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
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Ccn3
cellular communication network factor 3
affects expression
EXP
Chlorpromazine affects the expression of CCN3 mRNA
CTD
PMID:31324950
NCBI chr 7:86,094,000...86,101,022
Ensembl chr 7:86,094,000...86,101,019
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Ccnb2
cyclin B2
decreases expression
ISO
Chlorpromazine analog results in decreased expression of CCNB2 mRNA; Chlorpromazine results in decreased expression of CCNB2 mRNA
CTD
PMID:15924885
NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874
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Ccnd1
cyclin D1
decreases expression
EXP
Chlorpromazine results in decreased expression of CCND1 mRNA
CTD
PMID:17202759
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Ccnd3
cyclin D3
decreases expression
ISO
Chlorpromazine analog results in decreased expression of CCND3 mRNA
CTD
PMID:15924885
NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
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Ccnf
cyclin F
decreases expression
ISO
Chlorpromazine analog results in decreased expression of CCNF mRNA
CTD
PMID:15924885
NCBI chr10:13,253,073...13,279,140
Ensembl chr10:13,253,380...13,279,101
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Cd274
CD274 molecule
multiple interactions
ISO
Chlorpromazine inhibits the reaction [platycodin D results in decreased expression of and results in increased secretion of CD274 protein]
CTD
PMID:31150782
NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450
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Cd44
CD44 molecule
multiple interactions decreases expression
ISO
Chlorpromazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD44 protein] Chlorpromazine results in decreased expression of CD44 protein
CTD
PMID:9929743 PMID:30703373
NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
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Cd86
CD86 molecule
increases expression
ISO
Chlorpromazine results in increased expression of CD86 protein
CTD
PMID:19665512
NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
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Cdk5
cyclin-dependent kinase 5
decreases expression
ISO
Chlorpromazine analog results in decreased expression of CDK5 mRNA
CTD
PMID:15924885
NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112
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Cdk7
cyclin-dependent kinase 7
increases expression
ISO
Chlorpromazine analog results in increased expression of CDK7 mRNA
CTD
PMID:15924885
NCBI chr 2:31,840,558...31,865,422
Ensembl chr 2:31,840,558...31,865,383
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
multiple interactions increases expression
EXP
[EGR1 binds to CDKN1A promoter] promotes the reaction [Chlorpromazine results in increased expression of CDKN1A mRNA]; EGR1 promotes the reaction [Chlorpromazine results in increased expression of CDKN1A mRNA]
CTD
PMID:20368687
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cdkn2c
cyclin-dependent kinase inhibitor 2C
decreases expression
ISO
Chlorpromazine analog results in decreased expression of CDKN2C mRNA
CTD
PMID:15924885
NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278
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Ces2h
carboxylesterase 2H
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of CES2 mRNA
CTD
PMID:27344345
NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
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Cfh
complement factor H
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of CFH mRNA
CTD
PMID:27344345
NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838
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Cgref1
cell growth regulator with EF hand domain 1
decreases expression
EXP
Chlorpromazine results in decreased expression of CGREF1 mRNA
CTD
PMID:17202759
NCBI chr 6:25,431,846...25,443,853
Ensembl chr 6:25,431,799...25,443,852
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Chtf18
chromosome transmission fidelity factor 18
decreases expression
ISO
Chlorpromazine analog results in decreased expression of CHTF18 mRNA
CTD
PMID:15924885
NCBI chr10:14,743,006...14,751,044
Ensembl chr10:14,742,621...14,751,050
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Cited2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
decreases expression
EXP
Chlorpromazine results in decreased expression of CITED2 mRNA
CTD
PMID:18246545
NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897
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Cks2
CDC28 protein kinase regulatory subunit 2
decreases expression
ISO
Chlorpromazine analog results in decreased expression of CKS2 mRNA
CTD
PMID:15924885
NCBI chr17:13,570,611...13,575,770
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Clcf1
cardiotrophin-like cytokine factor 1
increases expression
ISO
Chlorpromazine results in increased expression of CLCF1 mRNA
CTD
PMID:21683644
NCBI chr 1:201,507,763...201,517,607
Ensembl chr 1:201,507,859...201,517,605
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Col18a1
collagen type XVIII alpha 1 chain
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of COL18A1 mRNA
CTD
PMID:27344345
NCBI chr20:11,474,104...11,582,593
Ensembl chr20:11,474,104...11,582,593
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Col1a1
collagen type I alpha 1 chain
increases expression
ISO
Chlorpromazine results in increased expression of COL1A1 mRNA
CTD
PMID:35708773
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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Col4a1
collagen type IV alpha 1 chain
decreases expression
EXP
Chlorpromazine results in decreased expression of COL4A1 mRNA
CTD
PMID:25596134
NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412
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Cort
cortistatin
affects expression
EXP
Chlorpromazine affects the expression of CORT mRNA
CTD
PMID:31324950
NCBI chr 5:159,560,591...159,562,032
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Cox8a
cytochrome c oxidase subunit 8A
affects expression increases expression
EXP
Chlorpromazine affects the expression of COX8A mRNA Chlorpromazine results in increased expression of COX8A mRNA
CTD
PMID:18246545
NCBI chr 1:204,402,118...204,404,439
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Crh
corticotropin releasing hormone
decreases expression
ISO
Chlorpromazine results in decreased expression of CRH mRNA
CTD
PMID:16205782
NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
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Cth
cystathionine gamma-lyase
decreases expression
EXP
Chlorpromazine results in decreased expression of CTH mRNA
CTD
PMID:25596134
NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234
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Ctsk
cathepsin K
multiple interactions
ISO
Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]
CTD
PMID:21869564
NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions decreases activity decreases response to substance increases expression
ISO EXP
[Filipin co-treated with Chlorpromazine co-treated with Wortmannin] inhibits the reaction [Particulate Matter results in increased expression of CYP1A1 mRNA]; Chlorpromazine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] Chlorpromazine results in decreased activity of CYP1A1 protein CYP1A1 protein results in decreased susceptibility to Chlorpromazine Chlorpromazine results in increased expression of CYP1A1 mRNA
CTD
PMID:17202759 PMID:18246545 PMID:18493746 PMID:25596134 PMID:26477383 PMID:29724254 PMID:33814510 More...
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
multiple interactions decreases response to substance increases expression increases oxidation affects expression decreases methylation
ISO EXP
[Chlorpromazine co-treated with Cholic Acids] affects the expression of CYP1A2 mRNA; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Chlorpromazine; Chlorpromazine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]; CYP1A2 protein results in increased metabolism of and results in increased activity of Chlorpromazine CYP1A2 protein results in decreased susceptibility to Chlorpromazine Chlorpromazine results in increased expression of CYP1A2 mRNA CYP1A2 protein results in increased oxidation of Chlorpromazine Chlorpromazine affects the expression of CYP1A2 mRNA CYP1A2 protein results in decreased methylation of Chlorpromazine
CTD
PMID:18246545 PMID:18493746 PMID:19482014 PMID:20615392 PMID:23397584 PMID:25596134 PMID:26477383 PMID:27344345 More...
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
decreases response to substance decreases activity multiple interactions
ISO
CYP1B1 protein results in decreased susceptibility to Chlorpromazine Chlorpromazine results in decreased activity of CYP1B1 protein [Filipin co-treated with Chlorpromazine co-treated with Wortmannin] inhibits the reaction [Particulate Matter results in increased expression of CYP1B1 mRNA]
CTD
PMID:26477383 PMID:29724254 PMID:33814510
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
multiple interactions decreases response to substance
ISO
[Chlorpromazine results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; Chlorpromazine inhibits the reaction [Androstenols inhibits the reaction [NR1I3 protein results in increased expression of CYP2B6 mRNA]] NR1I3 protein affects the reaction [Chlorpromazine results in increased expression of CYP2B10 mRNA] CYP2B6 protein results in decreased susceptibility to Chlorpromazine
CTD
PMID:10037683 PMID:12049174 PMID:17041008 PMID:26477383
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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Cyp2c11
cytochrome P450, subfamily 2, polypeptide 11
decreases expression decreases response to substance
EXP ISO
Chlorpromazine results in decreased expression of CYP2C mRNA; Chlorpromazine results in decreased expression of CYP2C11 mRNA CYP2C18 protein results in decreased susceptibility to Chlorpromazine
CTD
PMID:18246545 PMID:26477383
NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
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Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
multiple interactions decreases response to substance decreases activity affects methylation
ISO
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Chlorpromazine CYP2C19 protein results in decreased susceptibility to Chlorpromazine Chlorpromazine results in decreased activity of CYP2C19 protein CYP2C19 protein affects the methylation of Chlorpromazine
CTD
PMID:15135088 PMID:20615392 PMID:23397584 PMID:26477383
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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Cyp2c79
cytochrome P450, family 2, subfamily c, polypeptide 79
decreases response to substance
ISO
CYP2C8 protein results in decreased susceptibility to Chlorpromazine
CTD
PMID:26477383
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Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
multiple interactions decreases response to substance
ISO
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Chlorpromazine; CYP2D6 protein results in increased metabolism of and results in increased activity of Chlorpromazine CYP2D6 protein results in decreased susceptibility to Chlorpromazine
CTD
PMID:19482014 PMID:23397584 PMID:26477383
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
decreases activity decreases response to substance
ISO
Chlorpromazine results in decreased activity of CYP2E1 protein CYP2E1 protein results in decreased susceptibility to Chlorpromazine
CTD
PMID:15135088 PMID:26477383
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
affects methylation affects oxidation multiple interactions decreases response to substance decreases activity
ISO
CYP3A4 protein affects the methylation of Chlorpromazine CYP3A4 protein affects the oxidation of Chlorpromazine [Chlorpromazine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Chlorpromazine CYP3A4 protein results in decreased susceptibility to Chlorpromazine Chlorpromazine results in decreased activity of CYP3A4 protein
CTD
PMID:15135088 PMID:17041008 PMID:20615392 PMID:23397584 PMID:26477383
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Cyp3a9
cytochrome P450, family 3, subfamily a, polypeptide 9
decreases response to substance
ISO
CYP3A5 protein results in decreased susceptibility to Chlorpromazine
CTD
PMID:26477383
NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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Cyp8b1
cytochrome P450 family 8 subfamily B member 1
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of CYP8B1 mRNA
CTD
PMID:27344345
NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
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Dao
D-amino-acid oxidase
decreases activity
ISO
Chlorpromazine results in decreased activity of DAO protein
CTD
PMID:18615285
NCBI chr12:42,592,342...42,613,046
Ensembl chr12:42,592,343...42,612,741
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Dcstamp
dendrocyte expressed seven transmembrane protein
multiple interactions
ISO
Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA]
CTD
PMID:21869564
NCBI chr 7:70,807,455...70,822,067
Ensembl chr 7:70,807,581...70,822,078
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Ddit3
DNA-damage inducible transcript 3
increases expression
EXP
Chlorpromazine results in increased expression of DDIT3 mRNA
CTD
PMID:25596134
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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Depp1
DEPP autophagy regulator 1
increases expression
ISO
Chlorpromazine results in increased expression of DEPP1 mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542
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Drd1
dopamine receptor D1
decreases activity
ISO
Chlorpromazine results in decreased activity of DRD1 protein
CTD
PMID:23611293
NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
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Drd2
dopamine receptor D2
decreases response to substance decreases activity
ISO
DRD2 polymorphism results in decreased susceptibility to Chlorpromazine Chlorpromazine results in decreased activity of DRD2 protein
CTD
PMID:15694263 PMID:23611293
NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
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Dusp1
dual specificity phosphatase 1
increases expression affects expression
ISO
Chlorpromazine analog results in increased expression of DUSP1 mRNA Chlorpromazine affects the expression of DUSP1 mRNA
CTD
PMID:15924885 PMID:20843724
NCBI chr10:16,680,478...16,683,275
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Dusp9
dual specificity phosphatase 9
decreases expression
ISO
Chlorpromazine analog results in decreased expression of DUSP9 mRNA
CTD
PMID:15924885
NCBI chr X:151,351,897...151,355,822
Ensembl chr X:151,351,897...151,355,821
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E2f1
E2F transcription factor 1
decreases expression
ISO
Chlorpromazine analog results in decreased expression of E2F1 mRNA
CTD
PMID:15924885
NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
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Egr1
early growth response 1
increases expression multiple interactions
EXP
Chlorpromazine results in increased expression of EGR1 [EGR1 binds to CDKN1A promoter] promotes the reaction [Chlorpromazine results in increased expression of CDKN1A mRNA]; EGR1 promotes the reaction [Chlorpromazine results in increased expression of CDKN1A mRNA]; MAPK1 affects the reaction [Chlorpromazine results in increased expression of EGR1]; MAPK3 affects the reaction [Chlorpromazine results in increased expression of EGR1]
CTD
PMID:20368687
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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Eif1
eukaryotic translation initiation factor 1
increases expression
EXP
Chlorpromazine results in increased expression of EIF1 mRNA
CTD
PMID:25596134
NCBI chr10:85,246,751...85,248,842
Ensembl chr10:85,246,764...85,427,327
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Eno2
enolase 2
increases expression
EXP
Chlorpromazine results in increased expression of ENO2 mRNA
CTD
PMID:25596134
NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980
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Ero1a
endoplasmic reticulum oxidoreductase 1 alpha
increases expression
EXP
Chlorpromazine results in increased expression of ERO1A mRNA
CTD
PMID:25596134
NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478
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F2
coagulation factor II, thrombin
decreases expression
ISO
Chlorpromazine analog results in decreased expression of F2 mRNA
CTD
PMID:15924885
NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
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Fabp1
fatty acid binding protein 1
increases expression
ISO
Chlorpromazine results in increased expression of FABP1 mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
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Fas
Fas cell surface death receptor
increases expression
ISO
Chlorpromazine analog results in increased expression of FAS mRNA
CTD
PMID:15924885
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Fbp1
fructose-bisphosphatase 1
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of FBP1 mRNA
CTD
PMID:27344345
NCBI chr17:2,207,271...2,230,076
Ensembl chr17:2,208,031...2,230,071
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Fbxo22
F-box protein 22
decreases expression
EXP
Chlorpromazine results in decreased expression of FBXO22 mRNA
CTD
PMID:25596134
NCBI chr 8:55,579,906...55,595,981
Ensembl chr 8:55,579,891...55,596,148
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Fech
ferrochelatase
decreases expression
EXP
Chlorpromazine results in decreased expression of FECH mRNA
CTD
PMID:25596134
NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348
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Fetub
fetuin B
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of FETUB mRNA
CTD
PMID:27344345
NCBI chr11:78,082,158...78,093,022
Ensembl chr11:78,082,156...78,095,135
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Fga
fibrinogen alpha chain
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of FGA mRNA
CTD
PMID:27344345
NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528
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Fgf2
fibroblast growth factor 2
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of FGF2 mRNA
CTD
PMID:27344345
NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
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Fgfr1
Fibroblast growth factor receptor 1
decreases expression
ISO
Chlorpromazine analog results in decreased expression of FGFR1 mRNA
CTD
PMID:15924885
NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350
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Fgr
FGR proto-oncogene, Src family tyrosine kinase
decreases expression
EXP
Chlorpromazine results in decreased expression of FGR mRNA
CTD
PMID:25596134
NCBI chr 5:145,189,814...145,219,571
Ensembl chr 5:145,189,841...145,217,326
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Fkbp5
FKBP prolyl isomerase 5
multiple interactions
ISO
Chlorpromazine inhibits the reaction [Lipopolysaccharides results in decreased expression of FKBP5 protein]
CTD
PMID:21034739
NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674
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Fndc4
fibronectin type III domain containing 4
increases expression
ISO
Chlorpromazine results in increased expression of FNDC4 mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr 6:25,077,155...25,080,812
Ensembl chr 6:25,077,349...25,080,675
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
affects expression
ISO
Chlorpromazine affects the expression of FOS mRNA
CTD
PMID:20843724
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Fosb
FosB proto-oncogene, AP-1 transcription factor subunit
affects expression
ISO
Chlorpromazine affects the expression of FOSB mRNA
CTD
PMID:20843724
NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465
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Fosl1
FOS like 1, AP-1 transcription factor subunit
increases expression affects expression
ISO
Chlorpromazine analog results in increased expression of FOSL1 mRNA Chlorpromazine affects the expression of FOSL1 mRNA
CTD
PMID:15924885 PMID:20843724
NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
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Fosl2
FOS like 2, AP-1 transcription factor subunit
affects expression
ISO
Chlorpromazine affects the expression of FOSL2 mRNA
CTD
PMID:20843724
NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034
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Fth1
ferritin heavy chain 1
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of FTH1 mRNA
CTD
PMID:27344345
NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
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G6pd
glucose-6-phosphate dehydrogenase
decreases expression decreases activity multiple interactions
ISO EXP
Chlorpromazine analog results in decreased expression of G6PD mRNA Chlorpromazine results in decreased activity of G6PD protein [Taurine co-treated with coenzyme Q10] inhibits the reaction [Chlorpromazine results in decreased activity of G6PD protein]; coenzyme Q10 inhibits the reaction [Chlorpromazine results in decreased activity of G6PD protein]; Taurine inhibits the reaction [Chlorpromazine results in decreased activity of G6PD protein]
CTD
PMID:15924885 PMID:33548410
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
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Gad1
glutamate decarboxylase 1
decreases methylation multiple interactions
ISO
Chlorpromazine results in decreased methylation of GAD1 promoter Valproic Acid promotes the reaction [Chlorpromazine results in decreased methylation of GAD1 promoter]
CTD
PMID:19110320
NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
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Gcgr
glucagon receptor
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of GCGR mRNA
CTD
PMID:27344345
NCBI chr10:105,808,474...105,816,641
Ensembl chr10:105,808,473...105,816,640
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Gclc
glutamate-cysteine ligase, catalytic subunit
decreases expression
EXP
Chlorpromazine results in decreased expression of GCLC mRNA
CTD
PMID:25596134
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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Gdf15
growth differentiation factor 15
increases expression
EXP
Chlorpromazine results in increased expression of GDF15 mRNA
CTD
PMID:25596134
NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055
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Gdpd3
glycerophosphodiester phosphodiesterase domain containing 3
increases expression
ISO
Chlorpromazine results in increased expression of GDPD3 mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr 1:181,373,505...181,383,063
Ensembl chr 1:181,366,626...181,383,063
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Gfap
glial fibrillary acidic protein
affects expression
EXP
Chlorpromazine affects the expression of GFAP mRNA
CTD
PMID:31324950
NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
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Gpnmb
glycoprotein nmb
increases expression
EXP
Chlorpromazine results in increased expression of GPNMB mRNA
CTD
PMID:25596134
NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367
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Gpt
glutamic--pyruvic transaminase
increases expression
EXP
Chlorpromazine results in increased expression of GPT protein
CTD
PMID:35722787
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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Gsr
glutathione-disulfide reductase
decreases activity
EXP
Chlorpromazine results in decreased activity of GSR protein
CTD
PMID:6693892
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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Gsta1
glutathione S-transferase alpha 1
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of GSTA1 mRNA
CTD
PMID:27344345
NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
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Hif1a
hypoxia inducible factor 1 subunit alpha
affects activity
EXP
Chlorpromazine affects the activity of HIF1A protein
CTD
PMID:25596134
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
increases expression
ISO
Chlorpromazine results in increased expression of HMGCR mRNA
CTD
PMID:17052361
NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
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Hmgcs1
3-hydroxy-3-methylglutaryl-CoA synthase 1
increases expression
ISO
Chlorpromazine results in increased expression of HMGCS1 mRNA
CTD
PMID:17052361
NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
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Hmox1
heme oxygenase 1
increases expression affects expression
ISO EXP
Chlorpromazine results in increased expression of HMOX1 mRNA Chlorpromazine affects the expression of HMOX1 mRNA
CTD
PMID:15924885 PMID:25596134 PMID:31324950
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Hpn
hepsin
increases expression
ISO
Chlorpromazine results in increased expression of HPN mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811
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Hspa2
heat shock protein family A (Hsp70) member 2
increases expression decreases expression
EXP
Chlorpromazine results in increased expression of HSPA2 mRNA Chlorpromazine results in decreased expression of HSPA2 mRNA; Chlorpromazine results in decreased expression of HSPA2 protein
CTD
PMID:36751017
NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287
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Hspb1
heat shock protein family B (small) member 1
increases expression decreases expression
EXP
Chlorpromazine results in increased expression of HSPB1 mRNA Chlorpromazine results in decreased expression of HSPB1 mRNA
CTD
PMID:36751017
NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
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Hspd1
heat shock protein family D (Hsp60) member 1
increases expression
EXP
Chlorpromazine results in increased expression of HSPD1 mRNA
CTD
PMID:36751017
NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
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Hspe1
heat shock protein family E (Hsp10) member 1
increases expression
EXP
Chlorpromazine results in increased expression of HSPE1 mRNA
CTD
PMID:36751017
NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089
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Ibsp
integrin-binding sialoprotein
decreases expression multiple interactions
EXP
Chlorpromazine results in decreased expression of IBSP mRNA herbimycin inhibits the reaction [Chlorpromazine results in decreased expression of IBSP mRNA]; U 0126 inhibits the reaction [Chlorpromazine results in decreased expression of IBSP mRNA]
CTD
PMID:16294319
NCBI chr14:5,439,825...5,452,570
Ensembl chr14:5,439,829...5,452,693
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Ifnb1
interferon beta 1
multiple interactions
ISO
Chlorpromazine promotes the reaction [PAM2-CSK4 results in increased expression of IFNB1 mRNA]
CTD
PMID:32796029
NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523
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Ifng
interferon gamma
multiple interactions
ISO
[Chlorpromazine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA
CTD
PMID:29594315
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Ifnlr1
interferon, lambda receptor 1
increases expression
ISO
Chlorpromazine results in increased expression of IFNLR1 mRNA
CTD
PMID:21683644
NCBI chr 5:147,919,547...147,942,328
Ensembl chr 5:147,919,908...147,942,332
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Igfbp1
insulin-like growth factor binding protein 1
increases expression
ISO
Chlorpromazine results in increased expression of IGFBP1 mRNA
CTD
PMID:15924885
NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
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Ikbkg
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
increases expression
ISO
Chlorpromazine analog results in increased expression of IKBKG mRNA
CTD
PMID:15924885
NCBI chr X:152,216,485...152,241,476
Ensembl chr X:152,216,596...152,239,499
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Il1a
interleukin 1 alpha
multiple interactions
ISO
[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Chlorpromazine
CTD
PMID:19362101
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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Il1b
interleukin 1 beta
decreases expression
ISO
Chlorpromazine results in decreased expression of IL1B mRNA
CTD
PMID:29594315
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il2
interleukin 2
multiple interactions
ISO
[Chlorpromazine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA; Chlorpromazine inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK1 protein]; Chlorpromazine inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK3 protein]
CTD
PMID:11014349 PMID:29594315
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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Il6
interleukin 6
multiple interactions
ISO
[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Chlorpromazine
CTD
PMID:19362101
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Inhbe
inhibin subunit beta E
increases expression
ISO
Chlorpromazine results in increased expression of INHBE mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172
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Ins1
insulin 1
decreases secretion
EXP
Chlorpromazine results in decreased secretion of INS1 protein
CTD
PMID:18308779
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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Insig2
insulin induced gene 2
decreases expression
EXP
Chlorpromazine results in decreased expression of INSIG2 mRNA
CTD
PMID:25596134
NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923
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Irs2
insulin receptor substrate 2
multiple interactions
EXP
Chlorpromazine results in decreased expression of and results in decreased phosphorylation of IRS2 protein; Chlorpromazine results in decreased expression of and results in increased degradation of IRS2 protein
CTD
PMID:17512020 PMID:18308779
NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482
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Kcnh2
potassium voltage-gated channel subfamily H member 2
multiple interactions decreases activity
ISO
Chlorpromazine inhibits the reaction [KCNH2 protein results in increased transport of Thallium] Chlorpromazine results in decreased activity of KCNH2 protein
CTD
PMID:15071359 PMID:21158687 PMID:24052561
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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Kcnn2
potassium calcium-activated channel subfamily N member 2
decreases activity
EXP
Chlorpromazine results in decreased activity of KCNN2 protein
CTD
PMID:10915830
NCBI chr18:37,817,966...38,258,347
Ensembl chr18:37,817,957...38,258,347
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Klf4
KLF transcription factor 4
multiple interactions decreases expression
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of KLF4 mRNA Chlorpromazine results in decreased expression of KLF4 mRNA
CTD
PMID:27344345 PMID:30703373
NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602
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Klkb1
kallikrein B1
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of KLKB1 mRNA
CTD
PMID:27344345
NCBI chr16:46,958,634...46,982,054
Ensembl chr16:46,958,707...46,982,053
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Kng1
kininogen 1
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of KNG1 mRNA
CTD
PMID:27344345
NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555
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Lats1
large tumor suppressor kinase 1
increases phosphorylation
ISO
Chlorpromazine results in increased phosphorylation of LATS1 protein
CTD
PMID:30703373
NCBI chr 1:2,160,411...2,193,640
Ensembl chr 1:2,160,411...2,193,640
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Ldhc
lactate dehydrogenase C
decreases activity multiple interactions
EXP
Chlorpromazine results in decreased activity of LDHC protein [Taurine co-treated with coenzyme Q10] inhibits the reaction [Chlorpromazine results in decreased activity of LDHC protein]; coenzyme Q10 inhibits the reaction [Chlorpromazine results in decreased activity of LDHC protein]; Taurine inhibits the reaction [Chlorpromazine results in decreased activity of LDHC protein]
CTD
PMID:33548410
NCBI chr 1:97,385,984...97,403,382
Ensembl chr 1:97,382,379...97,403,378
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Ldlr
low density lipoprotein receptor
increases expression
ISO
Chlorpromazine results in increased expression of LDLR mRNA
CTD
PMID:17052361
NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
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Lep
leptin
increases expression
EXP
Chlorpromazine results in increased expression of LEP protein
CTD
PMID:17512020
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
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Lss
lanosterol synthase
increases expression
ISO
Chlorpromazine results in increased expression of LSS mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762
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Map2
microtubule-associated protein 2
increases expression
EXP
Chlorpromazine results in increased expression of MAP2 mRNA
CTD
PMID:15079866
NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809
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Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO EXP
Chlorpromazine inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK1 protein] MAPK1 affects the reaction [Chlorpromazine results in increased expression of EGR1]
CTD
PMID:11014349 PMID:20368687
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk14
mitogen activated protein kinase 14
decreases expression
ISO
Chlorpromazine analog results in decreased expression of MAPK14 mRNA
CTD
PMID:15924885
NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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Mapk3
mitogen activated protein kinase 3
decreases expression multiple interactions
ISO EXP
Chlorpromazine analog results in decreased expression of MAPK3 mRNA MAPK3 affects the reaction [Chlorpromazine results in increased expression of EGR1] Chlorpromazine inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK3 protein]
CTD
PMID:11014349 PMID:15924885 PMID:20368687
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mapk8
mitogen-activated protein kinase 8
multiple interactions
ISO
[Chlorpromazine co-treated with lipoteichoic acid] results in increased phosphorylation of MAPK8 protein; Chlorpromazine promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein]; TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipoteichoic acid] results in increased phosphorylation of MAPK8 protein]; TIRAP gene mutant form inhibits the reaction [Chlorpromazine promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein]]
CTD
PMID:23238562
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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Mapkapk2
MAPK activated protein kinase 2
increases expression
EXP
Chlorpromazine results in increased expression of MAPKAPK2 mRNA
CTD
PMID:19441803
NCBI chr13:42,513,762...42,560,061
Ensembl chr13:42,513,762...42,560,457
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Mcm3
minichromosome maintenance complex component 3
decreases expression
ISO
Chlorpromazine analog results in decreased expression of MCM3 mRNA
CTD
PMID:15924885
NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314
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Mcm5
minichromosome maintenance complex component 5
decreases expression
ISO
Chlorpromazine analog results in decreased expression of MCM5 mRNA
CTD
PMID:15924885
NCBI chr19:13,483,030...13,504,389
Ensembl chr19:13,483,066...13,504,389
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Mdm2
MDM2 proto-oncogene
increases expression
EXP
Chlorpromazine results in increased expression of MDM2 mRNA
CTD
PMID:25596134
NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
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Mitf
melanocyte inducing transcription factor
increases expression
ISO
Chlorpromazine results in increased expression of MITF protein
CTD
PMID:25449126
NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145
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Mki67
marker of proliferation Ki-67
decreases expression
ISO
Chlorpromazine analog results in decreased expression of MKI67 mRNA
CTD
PMID:15924885
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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Mmp9
matrix metallopeptidase 9
multiple interactions
ISO
Chlorpromazine inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased expression of MMP9 mRNA]; Chlorpromazine inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased secretion of MMP9 protein]
CTD
PMID:25200491
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Msc
musculin
decreases expression
EXP
Chlorpromazine results in decreased expression of MSC mRNA
CTD
PMID:25596134
NCBI chr 5:4,547,335...4,553,206
Ensembl chr 5:4,547,405...4,553,203
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Msh2
mutS homolog 2
decreases expression
ISO
Chlorpromazine results in decreased expression of MSH2 mRNA
CTD
PMID:15924885
NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938
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Mst1
macrophage stimulating 1
increases phosphorylation
ISO
Chlorpromazine results in increased phosphorylation of MST1 protein
CTD
PMID:30703373
NCBI chr 8:108,767,886...108,773,425
Ensembl chr 8:108,768,839...108,773,416
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Mt1
metallothionein 1
increases expression
EXP
Chlorpromazine results in increased expression of MT1A mRNA
CTD
PMID:8128501
NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049 Ensembl chr17:10,826,032...10,827,049
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Mybl2
MYB proto-oncogene like 2
decreases expression
ISO
Chlorpromazine analog results in decreased expression of MYBL2 mRNA
CTD
PMID:15924885
NCBI chr 3:151,705,254...151,733,714
Ensembl chr 3:151,705,288...151,733,708
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Myc
MYC proto-oncogene, bHLH transcription factor
decreases expression
ISO
Chlorpromazine results in decreased expression of MYC mRNA
CTD
PMID:30703373
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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Nampt
nicotinamide phosphoribosyltransferase
increases expression
EXP
Chlorpromazine results in increased expression of NAMPT mRNA
CTD
PMID:25596134
NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100
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Nanog
Nanog homeobox
decreases expression
ISO
Chlorpromazine results in decreased expression of NANOG mRNA
CTD
PMID:30703373
NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116
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Ndufs3
NADH:ubiquinone oxidoreductase core subunit S3
decreases expression
EXP
Chlorpromazine results in decreased expression of NDUFS3 protein
CTD
PMID:19441803
NCBI chr 3:76,876,646...76,883,824
Ensembl chr 3:76,876,646...76,883,824
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Nectin2
nectin cell adhesion molecule 2
multiple interactions
ISO
Chlorpromazine inhibits the reaction [Cadmium Chloride results in decreased expression of and affects the localization of NECTIN2 protein]
CTD
PMID:25046863
NCBI chr 1:79,372,123...79,407,379
Ensembl chr 1:79,372,119...79,407,360
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Nedd9
neural precursor cell expressed, developmentally down-regulated 9
decreases expression
EXP
Chlorpromazine results in decreased expression of NEDD9 mRNA
CTD
PMID:25596134
NCBI chr17:23,289,793...23,468,026
Ensembl chr17:23,282,326...23,468,019
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Nefh
neurofilament heavy chain
affects expression
EXP
Chlorpromazine affects the expression of NEFH mRNA
CTD
PMID:31324950
NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
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Nfatc1
nuclear factor of activated T-cells 1
multiple interactions
ISO
Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]
CTD
PMID:21869564
NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028
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Nfe2l2
NFE2 like bZIP transcription factor 2
decreases expression affects activity
EXP
Chlorpromazine results in decreased expression of NFE2L2 mRNA Chlorpromazine affects the activity of NFE2L2 protein
CTD
PMID:25596134
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Ninj1
ninjurin 1
increases expression
EXP
Chlorpromazine results in increased expression of NINJ1 mRNA
CTD
PMID:25596134
NCBI chr17:15,452,804...15,461,684
Ensembl chr17:15,452,813...15,461,704
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Nppb
natriuretic peptide B
increases expression
EXP
Chlorpromazine results in increased expression of NPPB protein
CTD
PMID:36751017
NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
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Nr0b2
nuclear receptor subfamily 0, group B, member 2
increases expression
ISO
Chlorpromazine results in increased expression of NR0B2 mRNA
CTD
PMID:17175557
NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
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Nr1h4
nuclear receptor subfamily 1, group H, member 4
decreases expression
EXP
Chlorpromazine results in decreased expression of NR1H4 mRNA
CTD
PMID:27765674 PMID:28391356
NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
increases expression multiple interactions
ISO
Chlorpromazine analog results in increased expression of NR1I2 mRNA [Chlorpromazine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CTD
PMID:15924885 PMID:17041008
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Nr1i3
nuclear receptor subfamily 1, group I, member 3
increases activity increases expression multiple interactions
ISO
Chlorpromazine results in increased activity of NR1I3 protein Chlorpromazine results in increased expression of NR1I3 mRNA [Chlorpromazine co-treated with Cholic Acids] affects the expression of NR1I3 mRNA; [Chlorpromazine results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; Chlorpromazine inhibits the reaction [Androstenols inhibits the reaction [NR1I3 protein results in increased expression of CYP2B6 mRNA]] NR1I3 protein affects the reaction [Chlorpromazine results in increased expression of CYP2B10 mRNA]; NR1I3 protein affects the reaction [Chlorpromazine results in increased expression of CYP3A11 mRNA]
CTD
PMID:10037683 PMID:12049174 PMID:12948398 PMID:17041008 PMID:22310298 PMID:27344345 More...
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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Nr3c1
nuclear receptor subfamily 3, group C, member 1
multiple interactions
ISO
Chlorpromazine inhibits the reaction [Corticosterone results in increased activity of NR3C1 protein]
CTD
PMID:16581232
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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Nupr1
nuclear protein 1, transcriptional regulator
increases expression
ISO
Chlorpromazine results in increased expression of NUPR1 mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281
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Orc1
origin recognition complex, subunit 1
decreases expression
ISO
Chlorpromazine analog results in decreased expression of ORC1 mRNA
CTD
PMID:15924885
NCBI chr 5:123,324,273...123,348,375
Ensembl chr 5:123,324,315...123,348,375
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Orm1
orosomucoid 1
affects binding multiple interactions
ISO
Chlorpromazine binds to ORM1 protein alternative form Chlorpromazine inhibits the reaction [Warfarin binds to ORM1 protein alternative form]
CTD
PMID:8946472
NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154
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Pdia2
protein disulfide isomerase family A, member 2
increases expression
ISO
Chlorpromazine analog results in increased expression of PDIA2 mRNA
CTD
PMID:15924885
NCBI chr10:15,215,824...15,218,937
Ensembl chr10:15,215,824...15,220,931
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Pdia5
protein disulfide isomerase family A, member 5
decreases expression
EXP
Chlorpromazine results in decreased expression of PDIA5 mRNA
CTD
PMID:25596134
NCBI chr11:65,272,152...65,359,087
Ensembl chr11:65,272,155...65,359,084
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Pdk1
pyruvate dehydrogenase kinase 1
increases expression
EXP
Chlorpromazine results in increased expression of PDK1 mRNA
CTD
PMID:25596134
NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038
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Pdk4
pyruvate dehydrogenase kinase 4
increases expression
EXP
Chlorpromazine results in increased expression of PDK4 mRNA
CTD
PMID:25596134
NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850
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Phyh
phytanoyl-CoA 2-hydroxylase
increases expression
ISO
Chlorpromazine results in increased expression of PHYH mRNA
CTD
PMID:15342952
NCBI chr17:73,329,461...73,346,359
Ensembl chr17:73,329,082...73,346,409
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Pias1
protein inhibitor of activated STAT, 1
increases expression
ISO
Chlorpromazine results in increased expression of PIAS1 mRNA
CTD
PMID:21683644
NCBI chr 8:63,338,150...63,451,670
Ensembl chr 8:63,338,150...63,438,905
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Pim1
Pim-1 proto-oncogene, serine/threonine kinase
increases expression
ISO
Chlorpromazine analog results in increased expression of PIM1 mRNA
CTD
PMID:15924885
NCBI chr20:7,554,921...7,559,174
Ensembl chr20:7,554,921...7,559,174
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Pir
pirin
decreases expression
EXP
Chlorpromazine results in decreased expression of PIR mRNA
CTD
PMID:25596134
NCBI chr X:30,108,536...30,219,269
Ensembl chr X:30,108,538...30,219,218
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Plin2
perilipin 2
increases expression
EXP
Chlorpromazine results in increased expression of PLIN2 mRNA
CTD
PMID:25596134
NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319
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Pmepa1
prostate transmembrane protein, androgen induced 1
decreases expression
EXP
Chlorpromazine results in decreased expression of PMEPA1 mRNA
CTD
PMID:25596134
NCBI chr 3:162,011,884...162,060,343
Ensembl chr 3:162,012,751...162,060,454
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Pola1
DNA polymerase alpha 1, catalytic subunit
decreases expression
ISO
Chlorpromazine analog results in decreased expression of POLA1 mRNA
CTD
PMID:15924885
NCBI chr X:58,034,617...58,348,612
Ensembl chr X:58,034,619...58,348,536
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Pold4
DNA polymerase delta 4, accessory subunit
increases expression
ISO
Chlorpromazine analog results in increased expression of POLD4 mRNA
CTD
PMID:15924885
NCBI chr 1:201,526,591...201,528,406
Ensembl chr 1:201,526,665...201,528,401
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Pou5f1
POU class 5 homeobox 1
decreases expression
ISO
Chlorpromazine results in decreased expression of POU5F1 mRNA
CTD
PMID:30703373
NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
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Pparg
peroxisome proliferator-activated receptor gamma
affects activity
EXP
Chlorpromazine affects the activity of PPARG protein
CTD
PMID:25596134
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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Ppp1r15a
protein phosphatase 1, regulatory subunit 15A
increases expression
EXP
Chlorpromazine results in increased expression of PPP1R15A mRNA
CTD
PMID:25596134
NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
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Prkaa1
protein kinase AMP-activated catalytic subunit alpha 1
decreases phosphorylation
EXP
Chlorpromazine results in decreased phosphorylation of PRKAA1 protein
CTD
PMID:17512020
NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
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Prl
prolactin
increases expression
ISO
Chlorpromazine results in increased expression of PRL protein
CTD
PMID:718334 PMID:996201
NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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Rara
retinoic acid receptor, alpha
decreases expression
EXP
Chlorpromazine results in decreased expression of RARA mRNA
CTD
PMID:18246545
NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
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Rnd1
Rho family GTPase 1
decreases expression
EXP
Chlorpromazine results in decreased expression of RND1 mRNA
CTD
PMID:25596134
NCBI chr 7:129,821,311...129,828,385
Ensembl chr 7:129,821,311...129,828,399
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Rnd3
Rho family GTPase 3
decreases expression
EXP
Chlorpromazine results in decreased expression of RND3 mRNA
CTD
PMID:25596134
NCBI chr 3:35,571,929...35,589,283
Ensembl chr 3:35,571,143...35,589,327
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Rnf121
ring finger protein 121
decreases expression
EXP
Chlorpromazine results in decreased expression of RNF121 mRNA
CTD
PMID:25596134
NCBI chr 1:156,377,368...156,439,936
Ensembl chr 1:156,377,364...156,446,826
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Runx1
RUNX family transcription factor 1
increases expression
EXP
Chlorpromazine results in increased expression of RUNX1 mRNA
CTD
PMID:25596134
NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542
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Rxrg
retinoid X receptor gamma
affects response to substance
ISO
RXRG protein affects the susceptibility to Chlorpromazine
CTD
PMID:10336693
NCBI chr13:79,743,430...79,785,173
Ensembl chr13:79,743,563...79,785,167
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Sat1
spermidine/spermine N1-acetyl transferase 1
increases expression
EXP
Chlorpromazine results in increased expression of SAT1 mRNA
CTD
PMID:25596134
NCBI chr X:40,158,354...40,161,641
Ensembl chr X:40,157,046...40,196,813
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Sc5d
sterol-C5-desaturase
increases expression
ISO
Chlorpromazine results in increased expression of SC5D mRNA
CTD
PMID:17052361
NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273
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Serpina3n
serine (or cysteine) peptidase inhibitor, clade A, member 3N
increases expression
ISO
Chlorpromazine results in increased expression of SERPINA3 mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433
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Serpinh1
serpin family H member 1
increases expression
ISO
Chlorpromazine results in increased expression of SERPINH1 mRNA
CTD
PMID:35708773
NCBI chr 1:153,643,500...153,650,853
Ensembl chr 1:153,643,510...153,650,801
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Sesn1
sestrin 1
decreases expression
EXP
Chlorpromazine results in decreased expression of SESN1 mRNA
CTD
PMID:25596134
NCBI chr20:45,294,876...45,387,698
Ensembl chr20:45,294,871...45,387,697
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Sik1
salt-inducible kinase 1
decreases expression
EXP
Chlorpromazine results in decreased expression of SIK1 mRNA
CTD
PMID:25596134
NCBI chr20:9,949,407...9,959,036
Ensembl chr20:9,947,396...9,958,991
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Slc10a1
solute carrier family 10 member 1
decreases expression increases expression
EXP ISO
Chlorpromazine results in decreased expression of SLC10A1 mRNA Chlorpromazine results in increased expression of SLC10A1 mRNA
CTD
PMID:27765674 PMID:28391356 PMID:35708773
NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
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Slc12a8
solute carrier family 12, member 8
increases expression
EXP
Chlorpromazine results in increased expression of SLC12A8 mRNA
CTD
PMID:25596134
NCBI chr11:67,116,876...67,266,548
Ensembl chr11:67,116,877...67,266,834
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Slc19a1
solute carrier family 19 member 1
multiple interactions decreases activity
EXP
Chlorpromazine inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate] Chlorpromazine results in decreased activity of SLC19A1 protein
CTD
PMID:17482559
NCBI chr20:11,584,410...11,602,429
Ensembl chr20:11,584,411...11,601,972
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Slc1a5
solute carrier family 1 member 5
increases expression
EXP
Chlorpromazine results in increased expression of SLC1A5 mRNA
CTD
PMID:25596134
NCBI chr 1:77,456,849...77,470,952
Ensembl chr 1:77,456,694...77,470,952
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Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Chlorpromazine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Slc22a7
solute carrier family 22 member 7
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of SLC22A7 mRNA
CTD
PMID:27344345
NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921
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Slc2a3
solute carrier family 2 member 3
decreases expression
ISO
Chlorpromazine results in decreased expression of SLC2A3 mRNA
CTD
PMID:15342952
NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472
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Slc31a1
solute carrier family 31 member 1
multiple interactions
ISO
Chlorpromazine inhibits the reaction [Copper affects the localization of SLC31A1 protein]
CTD
PMID:12501239
NCBI chr 5:75,814,744...75,844,241
Ensembl chr 5:75,814,743...75,844,228
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Slc3a2
solute carrier family 3 member 2
increases expression
EXP
Chlorpromazine results in increased expression of SLC3A2 mRNA
CTD
PMID:25596134
NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931
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Slc51b
SLC51 subunit beta
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of SLC51B mRNA
CTD
PMID:27344345
NCBI chr 8:65,931,891...65,939,953
Ensembl chr 8:65,931,890...65,940,145
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Slc6a6
solute carrier family 6 member 6
increases expression
EXP
Chlorpromazine results in increased expression of SLC6A6 mRNA
CTD
PMID:25596134
NCBI chr 4:124,195,186...124,268,880
Ensembl chr 4:124,195,218...124,268,875
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Slco2b1
solute carrier organic anion transporter family, member 2b1
decreases expression
EXP
Chlorpromazine results in decreased expression of SLCO2B1 mRNA
CTD
PMID:25596134
NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353
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Sod1
superoxide dismutase 1
multiple interactions
EXP
Chlorpromazine inhibits the reaction [Copper inhibits the reaction [Trientine results in decreased activity of SOD1 protein]]
CTD
PMID:22362149
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Sox2
SRY-box transcription factor 2
decreases expression
ISO
Chlorpromazine results in decreased expression of SOX2 mRNA
CTD
PMID:30703373
NCBI chr 2:117,536,929...117,539,340
Ensembl chr 2:117,536,929...117,539,338
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Spp1
secreted phosphoprotein 1
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of SPP1 mRNA
CTD
PMID:27344345
NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
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Spsb1
splA/ryanodine receptor domain and SOCS box containing 1
increases expression
EXP
Chlorpromazine results in increased expression of SPSB1 mRNA
CTD
PMID:25596134
NCBI chr 5:160,358,292...160,418,541
Ensembl chr 5:160,358,308...160,418,468
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Src
SRC proto-oncogene, non-receptor tyrosine kinase
multiple interactions
EXP
Chlorpromazine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased phosphorylation of SRC protein]
CTD
PMID:29702141
NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
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Srebf2
sterol regulatory element binding transcription factor 2
multiple interactions
ISO
Chlorpromazine results in increased cleavage of and results in increased activity of SREBF2 protein
CTD
PMID:17052361
NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848
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Strbp
spermatid perinuclear RNA binding protein
increases expression
EXP
Chlorpromazine results in increased expression of STRBP mRNA
CTD
PMID:25596134
NCBI chr 3:21,328,310...21,467,753
Ensembl chr 3:21,337,855...21,414,949
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Sts
steroid sulfatase
multiple interactions
ISO
Chlorpromazine inhibits the reaction [Tretinoin results in increased activity of STS protein]
CTD
PMID:16178010
NCBI chr X:42,225,131...42,233,403
Ensembl chr X:42,225,372...42,233,402
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Tagln
transgelin
decreases expression
ISO
Chlorpromazine results in decreased expression of TAGLN mRNA
CTD
PMID:17175557
NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668
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Tf
transferrin
affects localization
ISO
Chlorpromazine affects the localization of TF protein
CTD
PMID:12501239
NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
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Tfdp1
transcription factor Dp-1
decreases expression
ISO
Chlorpromazine analog results in decreased expression of TFDP1 mRNA
CTD
PMID:15924885
NCBI chr16:76,162,040...76,200,871
Ensembl chr16:76,162,043...76,200,817
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Tiparp
TCDD-inducible poly(ADP-ribose) polymerase
increases expression
EXP
Chlorpromazine results in increased expression of TIPARP mRNA
CTD
PMID:25596134
NCBI chr 2:149,753,682...149,780,327
Ensembl chr 2:149,753,682...149,780,327
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Tirap
TIR domain containing adaptor protein
multiple interactions
ISO
TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TNF protein]; TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipoteichoic acid] results in increased expression of TNF protein]; TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipoteichoic acid] results in increased phosphorylation of MAPK8 protein]; TIRAP gene mutant form inhibits the reaction [Chlorpromazine promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein]]; TIRAP protein results in increased susceptibility to [Chlorpromazine co-treated with lipopolysaccharide, Escherichia coli O111 B4]; TIRAP protein results in increased susceptibility to [Chlorpromazine co-treated with lipoteichoic acid]
CTD
PMID:23238562
NCBI chr 8:33,531,724...33,548,508
Ensembl chr 8:33,531,725...33,547,432
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Tnf
tumor necrosis factor
decreases expression increases response to substance multiple interactions
ISO
Chlorpromazine analog results in decreased expression of TNF protein; Chlorpromazine results in decreased expression of TNF mRNA TNF protein results in increased susceptibility to Chlorpromazine [Chlorpromazine co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TNF protein; [Chlorpromazine co-treated with lipoteichoic acid] results in increased expression of TNF protein; Chlorpromazine inhibits the reaction [[hydroquinone results in increased expression of TNF protein] which results in increased susceptibility to Methacholine Chloride]; Chlorpromazine inhibits the reaction [hydroquinone results in increased expression of TNF protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased susceptibility to Chlorpromazine]; TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TNF protein]; TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipoteichoic acid] results in increased expression of TNF protein] [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Chlorpromazine; Chlorpromazine results in decreased expression of and results in decreased activity of TNF protein
CTD
PMID:8550079 PMID:15052360 PMID:19362101 PMID:20371967 PMID:22414385 PMID:23238562 More...
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnfaip8
TNF alpha induced protein 8
increases expression
EXP
Chlorpromazine results in increased expression of TNFAIP8 mRNA
CTD
PMID:25596134
NCBI chr18:43,183,854...43,299,512
Ensembl chr18:43,183,916...43,299,517
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Tnfrsf14
TNF receptor superfamily member 14
increases expression
ISO
Chlorpromazine analog results in increased expression of TNFRSF14 mRNA
CTD
PMID:15924885
NCBI chr 5:165,486,069...165,494,421
Ensembl chr 5:165,484,262...165,493,703
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Tnfsf11
TNF superfamily member 11
decreases activity multiple interactions
ISO
Chlorpromazine results in decreased activity of TNFSF11; Chlorpromazine results in decreased activity of TNFSF11 protein Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]; Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA]; Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of CAR2 mRNA]; Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA]; Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]
CTD
PMID:21869564
NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445
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Tp53
tumor protein p53
affects activity
EXP
Chlorpromazine affects the activity of TP53 protein
CTD
PMID:25596134
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Trafd1
TRAF type zinc finger domain containing 1
decreases expression
EXP
Chlorpromazine results in decreased expression of TRAFD1 mRNA
CTD
PMID:25596134
NCBI chr12:35,165,606...35,179,525
Ensembl chr12:35,165,606...35,179,525
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Tuba1a
tubulin, alpha 1A
decreases expression
ISO
Chlorpromazine results in decreased expression of TUBA1A mRNA
CTD
PMID:27015953
NCBI chr 7:130,113,214...130,116,880
Ensembl chr 7:130,081,032...130,196,186
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Txn1
thioredoxin 1
decreases expression
EXP
Chlorpromazine results in decreased expression of TXN1 mRNA
CTD
PMID:25596134
NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
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Txnrd1
thioredoxin reductase 1
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of TXNRD1 mRNA
CTD
PMID:27344345
NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
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Tyr
tyrosinase
increases expression
ISO
Chlorpromazine results in increased expression of TYR protein
CTD
PMID:25449126
NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207
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Ung
uracil-DNA glycosylase
decreases expression
ISO
Chlorpromazine analog results in decreased expression of UNG mRNA
CTD
PMID:15924885
NCBI chr12:42,485,276...42,494,217
Ensembl chr12:42,485,276...42,494,206
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Unkl
unk like zinc finger
decreases expression
EXP
Chlorpromazine results in decreased expression of UNKL mRNA
CTD
PMID:25596134
NCBI chr10:14,206,125...14,252,226
Ensembl chr10:14,206,189...14,252,225
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Vegfa
vascular endothelial growth factor A
increases expression
ISO
Chlorpromazine analog results in increased expression of VEGFA mRNA
CTD
PMID:15924885
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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Vegfb
vascular endothelial growth factor B
increases expression
EXP
Chlorpromazine results in increased expression of VEGFB mRNA
CTD
PMID:25596134
NCBI chr 1:204,172,297...204,178,046
Ensembl chr 1:204,172,225...204,177,944
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Wars1
tryptophanyl-tRNA synthetase 1
increases expression
EXP
Chlorpromazine results in increased expression of WARS1 mRNA
CTD
PMID:25596134
NCBI chr 6:127,776,088...127,807,273
Ensembl chr 6:127,776,090...127,807,269
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Wipi1
WD repeat domain, phosphoinositide interacting 1
increases expression
ISO
Chlorpromazine results in increased expression of WIPI1 mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr10:94,542,946...94,580,174
Ensembl chr10:94,542,946...94,579,846
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Xbp1
X-box binding protein 1
affects activity decreases expression
EXP
Chlorpromazine affects the activity of XBP1 protein Chlorpromazine results in decreased expression of XBP1 mRNA
CTD
PMID:25596134
NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
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Xpc
XPC complex subunit, DNA damage recognition and repair factor
decreases expression
EXP
Chlorpromazine results in decreased expression of XPC mRNA
CTD
PMID:25596134
NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010
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Xrcc4
X-ray repair cross complementing 4
decreases expression
ISO
Chlorpromazine results in decreased expression of XRCC4 mRNA
CTD
PMID:15924885
NCBI chr 2:20,948,464...21,197,705
Ensembl chr 2:20,951,200...21,197,808
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Yap1
Yes1 associated transcriptional regulator
multiple interactions
ISO
Chlorpromazine results in decreased expression of and results in increased phosphorylation of and affects the localization of YAP1 protein
CTD
PMID:30703373
NCBI chr 8:5,095,705...5,166,808
Ensembl chr 8:5,095,722...5,167,010
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Kcnh2
potassium voltage-gated channel subfamily H member 2
decreases activity
ISO
Clopenthixol results in decreased activity of KCNH2 protein
CTD
PMID:28551711
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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Kcnh2
potassium voltage-gated channel subfamily H member 2
decreases activity multiple interactions
ISO
Droperidol results in decreased activity of KCNH2 protein Droperidol inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
CTD
PMID:16757186 PMID:21158687 PMID:28551711
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Droperidol inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Abcb1a
ATP binding cassette subfamily B member 1A
multiple interactions decreases activity
ISO
Flupenthixol analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]; Flupenthixol analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vincristine] Flupenthixol analog results in decreased activity of ABCB1 protein; Flupenthixol analog results in decreased activity of ABCB1 protein mutant form
CTD
PMID:7905786 PMID:12711602
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Drd1
dopamine receptor D1
affects binding
ISO
Flupenthixol binds to DRD1 protein
CTD
PMID:1352677
NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
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Kcnh2
potassium voltage-gated channel subfamily H member 2
decreases activity
ISO
Flupenthixol results in decreased activity of KCNH2 protein
CTD
PMID:28551711
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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Ptgs1
prostaglandin-endoperoxide synthase 1
decreases expression
ISO
Flupenthixol results in decreased expression of PTGS1 protein
CTD
PMID:8897462
NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
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Ptgs2
prostaglandin-endoperoxide synthase 2
decreases expression
ISO
Flupenthixol results in decreased expression of PTGS2 protein
CTD
PMID:8897462
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Alad
aminolevulinate dehydratase
multiple interactions decreases activity
EXP
[Fluphenazine co-treated with diphenyldiselenide] results in decreased activity of ALAD protein Fluphenazine results in decreased activity of ALAD protein
CTD
PMID:19486337
NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
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Ar
androgen receptor
multiple interactions
ISO
Fluphenazine binds to and results in decreased activity of AR protein
CTD
PMID:17606915
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Cat
catalase
multiple interactions increases activity
EXP
diphenyldiselenide inhibits the reaction [Fluphenazine results in increased activity of CAT protein]
CTD
PMID:19486337
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
decreases activity
ISO
Fluphenazine results in decreased activity of CYP2C19 protein
CTD
PMID:15135088
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
decreases activity
ISO
Fluphenazine results in decreased activity of CYP2E1 protein
CTD
PMID:15135088
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
decreases activity
ISO
Fluphenazine results in decreased activity of CYP3A4 protein
CTD
PMID:15135088
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Drd2
dopamine receptor D2
affects binding
ISO
Fluphenazine binds to DRD2 protein
CTD
PMID:17606915
NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
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Htr2a
5-hydroxytryptamine receptor 2A
affects binding
ISO
Fluphenazine binds to HTR2A protein
CTD
PMID:17606915
NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
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Htr2c
5-hydroxytryptamine receptor 2C
affects binding
ISO
Fluphenazine binds to HTR2C protein
CTD
PMID:17606915
NCBI chr X:110,640,777...110,870,288
Ensembl chr X:110,641,153...110,870,287
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Ngf
nerve growth factor
multiple interactions
EXP
Fluphenazine inhibits the reaction [NGF protein results in increased uptake of Calcium]
CTD
PMID:1374475
NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
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Prl
prolactin
increases secretion
ISO
Fluphenazine results in increased secretion of PRL protein
CTD
PMID:9989566
NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Fluphenazine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Tac1
tachykinin, precursor 1
decreases expression
ISO
Fluphenazine results in decreased expression of TAC1 mRNA
CTD
PMID:15845098
NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
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Tfeb
transcription factor EB
affects localization
ISO
Fluphenazine affects the localization of TFEB protein
CTD
PMID:28366621
NCBI chr 9:13,198,890...13,254,726
Ensembl chr 9:13,198,891...13,254,714
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Tmprss2
transmembrane serine protease 2
increases expression
EXP
Fluphenazine results in increased expression of TMPRSS2 mRNA
CTD
PMID:32808185
NCBI chr11:36,934,306...36,973,779
Ensembl chr11:36,934,306...36,973,715
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Abcb1a
ATP binding cassette subfamily B member 1A
multiple interactions decreases expression decreases activity
ISO
Haloperidol inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin] Haloperidol results in decreased expression of ABCB1 mRNA Haloperidol results in decreased activity of ABCB1 protein
CTD
PMID:15946544 PMID:16810505
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Abcc1
ATP binding cassette subfamily C member 1
multiple interactions decreases expression
ISO
Haloperidol inhibits the reaction [ABCC1 protein results in decreased susceptibility to Doxorubicin] Haloperidol results in decreased expression of ABCC1 mRNA
CTD
PMID:15946544
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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Abcg2
ATP binding cassette subfamily G member 2
multiple interactions
ISO
Haloperidol inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]
CTD
PMID:18834354
NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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Acadvl
acyl-CoA dehydrogenase, very long chain
decreases expression
ISO
Haloperidol results in decreased expression of ACADVL protein
CTD
PMID:34122009
NCBI chr10:54,732,875...54,738,102
Ensembl chr10:54,732,469...54,738,075
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Acat1
acetyl-CoA acetyltransferase 1
decreases expression
ISO
Haloperidol results in decreased expression of ACAT1 protein
CTD
PMID:34122009
NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855
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Acsl3
acyl-CoA synthetase long-chain family member 3
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of ACSL3 protein
CTD
PMID:34122009
NCBI chr 9:80,115,164...80,164,636
Ensembl chr 9:80,115,112...80,164,627
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Adam1a
ADAM metallopeptidase domain 1a
decreases expression
EXP
Haloperidol results in decreased expression of ADAM1A mRNA
CTD
PMID:16715494
NCBI chr12:35,017,433...35,020,300
Ensembl chr12:35,017,315...35,020,311
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Adcy5
adenylate cyclase 5
affects response to substance multiple interactions
ISO
ADCY5 protein affects the susceptibility to Haloperidol SCH 23390 inhibits the reaction [ADCY5 protein affects the susceptibility to Haloperidol]
CTD
PMID:12223546
NCBI chr11:65,471,612...65,618,877
Ensembl chr11:65,471,612...65,618,974
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Adcyap1r1
ADCYAP receptor type I
affects expression
ISO
Haloperidol affects the expression of ADCYAP1R1 mRNA
CTD
PMID:27900577
NCBI chr 4:84,593,558...84,642,700
Ensembl chr 4:84,593,892...84,642,700
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Adora2a
adenosine A2a receptor
affects response to substance
ISO
ADORA2A protein affects the susceptibility to Haloperidol
CTD
PMID:11172060
NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
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Adsl
adenylosuccinate lyase
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of ADSL protein
CTD
PMID:34122009
NCBI chr 7:112,479,256...112,503,439
Ensembl chr 7:112,479,271...112,503,760
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Agpat1
1-acylglycerol-3-phosphate O-acyltransferase 1
decreases expression
ISO
Haloperidol results in decreased expression of AGPAT1 mRNA
CTD
PMID:14647396
NCBI chr20:4,135,955...4,144,880
Ensembl chr20:4,135,957...4,145,278
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Agps
alkylglycerone phosphate synthase
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of AGPS protein
CTD
PMID:34122009
NCBI chr 3:60,747,323...60,845,831
Ensembl chr 3:60,747,323...60,845,830
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Ak4
adenylate kinase 4
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of AK4 protein
CTD
PMID:34122009
NCBI chr 5:116,039,222...116,099,064
Ensembl chr 5:116,039,616...116,098,618
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Akt1
AKT serine/threonine kinase 1
decreases expression
EXP
Haloperidol results in decreased expression of AKT1 mRNA
CTD
PMID:15860345
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Akt2
AKT serine/threonine kinase 2
increases expression
EXP
Haloperidol results in increased expression of AKT2 mRNA
CTD
PMID:15860345
NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
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Aldh18a1
aldehyde dehydrogenase 18 family, member A1
decreases expression
ISO
Haloperidol results in decreased expression of ALDH18A1 protein
CTD
PMID:34122009
NCBI chr 1:239,375,657...239,407,956
Ensembl chr 1:239,375,669...239,407,890
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Aldoa
aldolase, fructose-bisphosphate A
increases expression
EXP
Haloperidol results in increased expression of ALDOA mRNA
CTD
PMID:15860345
NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182
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Aldoc
aldolase, fructose-bisphosphate C
increases expression
EXP
Haloperidol results in increased expression of ALDOC mRNA
CTD
PMID:15860345
NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066
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Ankhd1
ankyrin repeat and KH domain containing 1
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of ANKHD1 protein
CTD
PMID:34122009
NCBI chr18:28,161,882...28,260,917
Ensembl chr18:28,162,311...28,268,024
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Ap2a2
adaptor related protein complex 2 subunit alpha 2
decreases expression
EXP
Haloperidol results in decreased expression of AP2A2 mRNA
CTD
PMID:15860345
NCBI chr 1:196,652,315...196,725,609
Ensembl chr 1:196,652,337...196,725,603
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Ap2b1
adaptor related protein complex 2 subunit beta 1
affects expression
EXP
Haloperidol affects the expression of AP2B1 mRNA
CTD
PMID:15860345
NCBI chr10:68,099,397...68,205,023
Ensembl chr10:68,099,547...68,205,013
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Ap2m1
adaptor related protein complex 2 subunit mu 1
increases expression
ISO
Haloperidol results in increased expression of AP2M1 protein
CTD
PMID:34122009
NCBI chr11:80,355,307...80,364,218
Ensembl chr11:80,328,041...80,364,140
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Ap3b1
adaptor related protein complex 3 subunit beta 1
increases expression
ISO
Haloperidol results in increased expression of AP3B1 protein
CTD
PMID:34122009
NCBI chr 2:25,600,069...25,800,937
Ensembl chr 2:25,600,040...25,800,935
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Apod
apolipoprotein D
increases expression
ISO
Haloperidol results in increased expression of APOD mRNA
CTD
PMID:14647396
NCBI chr11:69,431,261...69,452,306
Ensembl chr11:69,431,260...69,452,305
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Appl1
adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of APPL1 protein
CTD
PMID:34122009
NCBI chr16:2,118,503...2,166,741
Ensembl chr16:2,121,255...2,166,692
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Arc
activity-regulated cytoskeleton-associated protein
increases expression multiple interactions
EXP
Haloperidol results in increased expression of ARC mRNA 8-Hydroxy-2-(di-n-propylamino)tetralin inhibits the reaction [Haloperidol results in increased expression of ARC mRNA]
CTD
PMID:18208916 PMID:19695244
NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378
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Arf1
ADP-ribosylation factor 1
decreases expression
EXP
Haloperidol results in decreased expression of ARF1 mRNA
CTD
PMID:15860345
NCBI chr10:43,997,983...44,014,461
Ensembl chr10:43,997,986...44,014,434
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Arf3
ADP-ribosylation factor 3
decreases expression
EXP
Haloperidol results in decreased expression of ARF3 mRNA
CTD
PMID:15860345
NCBI chr 7:129,886,082...129,912,022
Ensembl chr 7:129,886,082...129,912,002
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Arl3
ADP ribosylation factor like GTPase 3
decreases expression
EXP
Haloperidol results in decreased expression of ARL3 mRNA
CTD
PMID:15860345
NCBI chr 1:245,400,659...245,446,673
Ensembl chr 1:245,400,550...245,446,820
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Arl5a
ADP-ribosylation factor like GTPase 5A
decreases expression
EXP
Haloperidol results in decreased expression of ARL5A mRNA
CTD
PMID:15860345
NCBI chr 3:36,878,461...36,903,362
Ensembl chr 3:36,880,712...36,903,211
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Arpc4
actin related protein 2/3 complex, subunit 4
increases expression
ISO
Haloperidol results in increased expression of ARPC4 mRNA
CTD
PMID:14647396
NCBI chr 4:146,522,255...146,532,784
Ensembl chr 4:146,522,176...146,532,785
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Asns
asparagine synthetase (glutamine-hydrolyzing)
decreases expression
ISO
Haloperidol results in decreased expression of ASNS mRNA
CTD
PMID:17175557
NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
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Asph
aspartate-beta-hydroxylase
increases expression
ISO
Haloperidol results in increased expression of ASPH protein
CTD
PMID:34122009
NCBI chr 5:22,601,581...22,814,107
Ensembl chr 5:22,603,486...22,813,876
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Atp1a1
ATPase Na+/K+ transporting subunit alpha 1
decreases expression
EXP
Haloperidol results in decreased expression of ATP1A1 mRNA
CTD
PMID:15860345
NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837
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Atp1a3
ATPase Na+/K+ transporting subunit alpha 3
decreases expression
EXP
Haloperidol results in decreased expression of ATP1A3 mRNA
CTD
PMID:15860345
NCBI chr 1:80,572,790...80,601,936
Ensembl chr 1:80,572,796...80,601,918
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Atp1b1
ATPase Na+/K+ transporting subunit beta 1
increases expression
EXP
Haloperidol results in increased expression of ATP1B1 mRNA
CTD
PMID:15860345
NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459
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Atp1b2
ATPase Na+/K+ transporting subunit beta 2
decreases expression
EXP
Haloperidol results in decreased expression of ATP1B2 mRNA
CTD
PMID:15860345
NCBI chr10:54,318,698...54,324,933
Ensembl chr10:54,318,701...54,324,933
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Atp1b3
ATPase Na+/K+ transporting subunit beta 3
increases expression
EXP
Haloperidol results in increased expression of ATP1B3 mRNA
CTD
PMID:15860345
NCBI chr 8:96,910,265...96,941,592
Ensembl chr 8:96,910,309...96,941,598
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Atp2a3
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of ATP2A3 protein
CTD
PMID:34122009
NCBI chr10:57,581,742...57,612,758
Ensembl chr10:57,582,128...57,612,748
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Atp6v1b1
ATPase H+ transporting V1 subunit B1
decreases expression
ISO
Haloperidol results in decreased expression of ATP6V1B1 protein
CTD
PMID:34122009
NCBI chr 4:116,223,799...116,242,475
Ensembl chr 4:116,223,799...116,242,475
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Atp6v1b2
ATPase H+ transporting V1 subunit B2
decreases expression
ISO
Haloperidol results in decreased expression of ATP6V1B2 mRNA
CTD
PMID:16465460
NCBI chr16:20,617,515...20,641,651
Ensembl chr16:20,617,518...20,641,745
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Axin2
axin 2
decreases expression
EXP
Haloperidol results in decreased expression of AXIN2 mRNA
CTD
PMID:16715494
NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231
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Bax
BCL2 associated X, apoptosis regulator
decreases expression increases expression
EXP
Haloperidol results in decreased expression of BAX protein Haloperidol results in increased expression of BAX mRNA; Haloperidol results in increased expression of BAX protein
CTD
PMID:16462815 PMID:17069804
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcat2
branched chain amino acid transaminase 2
decreases expression
ISO
Haloperidol results in decreased expression of BCAT2 protein
CTD
PMID:34122009
NCBI chr 1:96,040,407...96,060,008
Ensembl chr 1:96,042,625...96,060,007
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Bcl2
BCL2, apoptosis regulator
increases expression
EXP
Haloperidol results in increased expression of BCL2 protein
CTD
PMID:17069804
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bcl2l1
Bcl2-like 1
multiple interactions increases expression decreases expression
EXP
EPO protein inhibits the reaction [Haloperidol results in decreased expression of BCL2L1 protein] Haloperidol results in increased expression of BCL2L1 protein
CTD
PMID:16462815 PMID:17805306
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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Bdnf
brain-derived neurotrophic factor
multiple interactions increases expression decreases expression
EXP ISO
BDNF protein inhibits the reaction [Haloperidol results in increased activity of CASP3 protein]; EPO protein inhibits the reaction [Haloperidol results in decreased expression of BDNF protein]; Haloperidol inhibits the reaction [Rotenone results in decreased expression of BDNF mRNA] Haloperidol results in increased expression of BDNF mRNA Haloperidol results in increased expression of BDNF protein Haloperidol inhibits the reaction [Cocaine results in decreased expression of BDNF protein] Haloperidol results in decreased expression of BDNF mRNA; Haloperidol results in decreased expression of BDNF protein
CTD
PMID:11488957 PMID:12393228 PMID:12478621 PMID:15168214 PMID:17442543 PMID:17805306 PMID:18208916 PMID:20554863 PMID:29182611 More...
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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Bet1l
Bet1 golgi vesicular membrane trafficking protein-like
affects expression
EXP
Haloperidol affects the expression of BET1L mRNA
CTD
PMID:15860345
NCBI chr 1:195,931,407...195,935,072
Ensembl chr 1:195,931,411...195,935,040
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Bop1
BOP1 ribosomal biogenesis factor
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of BOP1 protein
CTD
PMID:34122009
NCBI chr 7:108,172,062...108,195,875
Ensembl chr 7:108,172,066...108,195,931
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Bptf
bromodomain PHD finger transcription factor
decreases expression
ISO
Haloperidol results in decreased expression of BPTF mRNA
CTD
PMID:14647396
NCBI chr10:91,980,279...92,082,731
Ensembl chr10:91,982,758...92,082,769
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Cacna1a
calcium voltage-gated channel subunit alpha1 A
decreases expression
EXP ISO
Haloperidol results in decreased expression of CACNA1A mRNA
CTD
PMID:14647396 PMID:16715494
NCBI chr19:23,520,741...23,819,971
Ensembl chr19:23,520,741...23,823,225
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Calca
calcitonin-related polypeptide alpha
affects activity
EXP
Haloperidol affects the activity of CALCA protein
CTD
PMID:10075105
NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
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Calm2
calmodulin 2
increases expression
EXP
Haloperidol results in increased expression of CALM2 mRNA
CTD
PMID:19289156
NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287 Ensembl chr15:7,091,567...7,104,287
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Camk2a
calcium/calmodulin-dependent protein kinase II alpha
multiple interactions increases expression decreases expression
EXP
Haloperidol results in decreased expression of and results in decreased phosphorylation of CAMK2A protein Haloperidol results in increased expression of CAMK2A mRNA Haloperidol results in decreased expression of CAMK2A protein
CTD
PMID:15860345 PMID:18061412 PMID:19289156
NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
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Camk2b
calcium/calmodulin-dependent protein kinase II beta
decreases expression
EXP
Haloperidol results in decreased expression of CAMK2B mRNA
CTD
PMID:15860345
NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994
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Camk2d
calcium/calmodulin-dependent protein kinase II delta
decreases expression
EXP
Haloperidol results in decreased expression of CAMK2D mRNA
CTD
PMID:15860345
NCBI chr 2:215,023,785...215,287,351
Ensembl chr 2:215,024,004...215,286,178
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Camk4
calcium/calmodulin-dependent protein kinase IV
decreases expression increases expression
EXP
Haloperidol results in decreased expression of CAMK4 protein Haloperidol results in increased expression of CAMK4 mRNA
CTD
PMID:15860345 PMID:19289156
NCBI chr18:24,582,988...24,811,918
Ensembl chr18:24,585,269...24,802,487
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Camkk1
calcium/calmodulin-dependent protein kinase kinase 1
decreases expression
EXP
Haloperidol results in decreased expression of CAMKK1 protein
CTD
PMID:19289156
NCBI chr10:57,637,335...57,660,498
Ensembl chr10:57,637,391...57,660,498
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Camkk2
calcium/calmodulin-dependent protein kinase kinase 2
decreases expression
EXP
Haloperidol results in decreased expression of CAMKK2 protein
CTD
PMID:19289156
NCBI chr12:33,791,023...33,845,000
Ensembl chr12:33,791,052...33,843,279
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Cap1
cyclase associated actin cytoskeleton regulatory protein 1
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of CAP1 protein
CTD
PMID:34122009
NCBI chr 5:135,142,108...135,168,885
Ensembl chr 5:135,142,112...135,168,769
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Casp3
caspase 3
multiple interactions increases expression increases activity
EXP
BDNF protein inhibits the reaction [Haloperidol results in increased activity of CASP3 protein]; EPO protein inhibits the reaction [Haloperidol results in increased expression of CASP3 protein]
CTD
PMID:15168214 PMID:17805306 PMID:18590723
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cat
catalase
multiple interactions decreases activity decreases expression
EXP ISO
Carvedilol inhibits the reaction [Haloperidol results in decreased expression of CAT protein]; Haloperidol results in decreased activity of and results in decreased expression of CAT protein; Zolpidem inhibits the reaction [Haloperidol results in decreased activity of CAT] Haloperidol results in decreased activity of CAT protein Cannabidiol inhibits the reaction [Haloperidol results in decreased activity of CAT protein]
CTD
PMID:12010767 PMID:12482469 PMID:16564057 PMID:17513028 PMID:30217539
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Cbx5
chromobox 5
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of CBX5 protein
CTD
PMID:34122009
NCBI chr 7:134,333,165...134,376,102
Ensembl chr 7:134,331,335...134,375,022
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Ccdc121
coiled-coil domain containing 121
increases expression
ISO
Haloperidol results in increased expression of CCDC121 protein
CTD
PMID:34122009
NCBI chr 6:24,970,845...24,973,451
Ensembl chr 6:24,970,833...24,973,478
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Cck
cholecystokinin
increases expression
EXP
Haloperidol results in increased expression of CCK mRNA
CTD
PMID:10974607
NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084
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Ccnd1
cyclin D1
decreases expression
EXP
Haloperidol results in decreased expression of CCND1 mRNA
CTD
PMID:15860345
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Ccnd3
cyclin D3
increases expression
EXP
Haloperidol results in increased expression of CCND3 mRNA
CTD
PMID:15860345
NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
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Ccnl1
cyclin L1
increases expression
EXP
Haloperidol results in increased expression of CCNL1 mRNA
CTD
PMID:15860345
NCBI chr 2:150,184,865...150,199,524
Ensembl chr 2:150,184,798...150,197,368
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Cct8
chaperonin containing TCP1 subunit 8
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of CCT8 protein
CTD
PMID:34122009
NCBI chr11:26,710,370...26,722,079
Ensembl chr11:26,710,370...26,722,079
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Cdc42
cell division cycle 42
increases expression
EXP
Haloperidol results in increased expression of CDC42 mRNA
CTD
PMID:15860345
NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111
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Cdk4
cyclin-dependent kinase 4
increases expression
EXP
Haloperidol results in increased expression of CDK4 mRNA
CTD
PMID:15860345
NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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Cdk5
cyclin-dependent kinase 5
increases expression
EXP
Haloperidol results in increased expression of CDK5 mRNA
CTD
PMID:15860345
NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112
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Cfap161
cilia and flagella associated protein 161
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of CFAP161 protein
CTD
PMID:34122009
NCBI chr 1:137,743,783...137,768,685
Ensembl chr 1:137,743,784...137,768,730
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Cfdp1
craniofacial development protein 1
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of CFDP1 protein
CTD
PMID:34122009
NCBI chr19:39,718,313...39,823,824
Ensembl chr19:39,718,347...39,823,824
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Cfl1
cofilin 1
increases expression
ISO
Haloperidol results in increased expression of CFL1 protein
CTD
PMID:34122009
NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587
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Chl1
cell adhesion molecule L1-like
decreases expression
ISO
Haloperidol results in decreased expression of CHL1 mRNA
CTD
PMID:14647396
NCBI chr 4:136,291,504...136,505,830
Ensembl chr 4:136,291,463...136,503,265
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Chn1
chimerin 1
decreases expression
ISO
Haloperidol results in decreased expression of CHN1 mRNA
CTD
PMID:14647396
NCBI chr 3:58,509,822...58,676,462
Ensembl chr 3:58,510,536...58,676,490
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Chordc1
cysteine and histidine rich domain containing 1
increases expression
ISO
Haloperidol results in increased expression of CHORDC1 protein
CTD
PMID:34122009
NCBI chr 8:15,374,356...15,398,436
Ensembl chr 8:15,374,471...15,399,162
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Chrm4
cholinergic receptor, muscarinic 4
affects response to substance
ISO
CHRM4 affects the susceptibility to Haloperidol
CTD
PMID:21269601
NCBI chr 3:77,893,425...77,901,166
Ensembl chr 3:77,893,425...77,901,159
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Cldn11
claudin 11
decreases expression
ISO
Haloperidol results in decreased expression of CLDN11 mRNA
CTD
PMID:17177202
NCBI chr 2:112,207,745...112,221,050
Ensembl chr 2:112,207,745...112,221,050
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Clta
clathrin, light chain A
affects expression
EXP
Haloperidol affects the expression of CLTA mRNA
CTD
PMID:15860345
NCBI chr 5:58,244,253...58,263,480
Ensembl chr 5:58,245,442...58,263,472
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Cltb
clathrin, light chain B
decreases expression
EXP
Haloperidol results in decreased expression of CLTB mRNA
CTD
PMID:15860345
NCBI chr17:10,001,512...10,019,201
Ensembl chr17:10,001,513...10,019,169
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Cmya5
cardiomyopathy associated 5
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of CMYA5 protein
CTD
PMID:34122009
NCBI chr 2:24,279,520...24,378,253
Ensembl chr 2:24,279,528...24,378,364
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Cnot3
CCR4-NOT transcription complex, subunit 3
decreases expression
ISO
Haloperidol results in decreased expression of CNOT3 protein
CTD
PMID:34122009
NCBI chr 1:65,555,924...65,572,167
Ensembl chr 1:65,555,924...65,572,167
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Cnp
2',3'-cyclic nucleotide 3' phosphodiesterase
decreases expression
ISO
Haloperidol results in decreased expression of CNP mRNA
CTD
PMID:17177202
NCBI chr10:85,511,164...85,517,723
Ensembl chr10:85,511,160...85,517,720
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Cnr1
cannabinoid receptor 1
multiple interactions increases methylation
ISO EXP
CNR1 protein affects the reaction [[potassium perchlorate co-treated with 2-mercapto-1-methylimidazole] inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK1 protein]]; CNR1 protein affects the reaction [[potassium perchlorate co-treated with 2-mercapto-1-methylimidazole] inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK3 protein]] Haloperidol results in increased methylation of CNR1 promoter Haloperidol inhibits the reaction [Methylazoxymethanol Acetate results in decreased methylation of CNR1 promoter]
CTD
PMID:28017790 PMID:30496751
NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
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Coil
coilin
increases expression
EXP
Haloperidol results in increased expression of COIL mRNA
CTD
PMID:16715494
NCBI chr10:73,789,077...73,810,378
Ensembl chr10:73,789,488...73,810,393
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Cops3
COP9 signalosome subunit 3
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of COPS3 protein
CTD
PMID:34122009
NCBI chr10:44,618,115...44,652,807
Ensembl chr10:44,618,115...44,641,597
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Cops4
COP9 signalosome subunit 4
decreases expression
ISO
Haloperidol results in decreased expression of COPS4 protein
CTD
PMID:34122009
NCBI chr14:9,078,579...9,108,788
Ensembl chr14:9,078,576...9,108,887
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Cpn1
carboxypeptidase N subunit 1
increases expression
EXP
Haloperidol results in increased expression of CPN1 mRNA
CTD
PMID:16715494
NCBI chr 1:242,844,575...242,873,465
Ensembl chr 1:242,844,212...242,873,465
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Cpne3
copine 3
decreases expression
ISO
Haloperidol results in decreased expression of CPNE3 protein
CTD
PMID:34122009
NCBI chr 5:33,014,658...33,063,934
Ensembl chr 5:33,016,307...33,063,934
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Creb1
cAMP responsive element binding protein 1
multiple interactions increases activity increases phosphorylation
ISO EXP
Clozapine inhibits the reaction [Haloperidol results in increased phosphorylation of CREB1 protein] Amphetamine affects the reaction [Haloperidol results in increased activity of CREB1 protein modified form]
CTD
PMID:12125044 PMID:12871586
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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Crh
corticotropin releasing hormone
decreases expression
ISO
Haloperidol results in decreased expression of CRH mRNA
CTD
PMID:16205782
NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
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Crhbp
corticotropin releasing hormone binding protein
decreases expression
EXP
Haloperidol results in decreased expression of CRHBP mRNA
CTD
PMID:16715494
NCBI chr 2:26,692,403...26,704,710
Ensembl chr 2:26,692,403...26,704,710
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Cry1
cryptochrome circadian regulator 1
decreases expression
ISO
Haloperidol results in decreased expression of CRY1 mRNA
CTD
PMID:27746588
NCBI chr 7:18,529,823...18,594,092
Ensembl chr 7:18,529,823...18,594,091
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Csnk2a1
casein kinase 2 alpha 1
decreases expression
EXP
Haloperidol results in decreased expression of CSNK2A1 mRNA
CTD
PMID:16715494
NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696
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Cst3
cystatin C
increases expression
ISO
Haloperidol results in increased expression of CST3 mRNA
CTD
PMID:14647396
NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:136,336,920...136,340,822
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Ctnna1
catenin alpha 1
decreases expression
ISO
Haloperidol results in decreased expression of CTNNA1 protein
CTD
PMID:34122009
NCBI chr18:26,728,246...26,860,911
Ensembl chr18:26,728,485...26,860,910
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Ctnnb1
catenin beta 1
decreases expression increases expression multiple interactions
ISO EXP
Haloperidol results in decreased expression of CTNNB1 mRNA Haloperidol results in increased expression of CTNNB1 protein DRD2 protein affects the reaction [Haloperidol results in increased expression of CTNNB1 protein]
CTD
PMID:16144542 PMID:18797397
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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Ctrl
chymotrypsin-like
increases expression
EXP
Haloperidol results in increased expression of CTRL mRNA
CTD
PMID:16715494
NCBI chr19:33,827,279...33,829,129
Ensembl chr19:33,827,229...33,833,626
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Ctsk
cathepsin K
increases expression
EXP
Haloperidol results in increased expression of CTSK mRNA
CTD
PMID:16715494
NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550
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Cyb5r1
cytochrome b5 reductase 1
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of CYB5R1 protein
CTD
PMID:34122009
NCBI chr13:45,849,017...45,855,458
Ensembl chr13:45,849,091...45,855,458
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Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
affects response to substance
ISO
CYP2D6 protein polymorphism affects the susceptibility to Haloperidol
CTD
PMID:15538130
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions
ISO
CYP3A4 protein results in increased oxidation of and results in increased activity of Haloperidol; Fluoxetine inhibits the reaction [CYP3A4 protein results in increased oxidation of and results in increased activity of Haloperidol]; Fluvoxamine inhibits the reaction [CYP3A4 protein results in increased oxidation of and results in increased activity of Haloperidol]; nefazodone inhibits the reaction [CYP3A4 protein results in increased oxidation of and results in increased activity of Haloperidol]; norfluoxetine inhibits the reaction [CYP3A4 protein results in increased oxidation of and results in increased activity of Haloperidol]; Trazodone inhibits the reaction [CYP3A4 protein results in increased oxidation of and results in increased activity of Haloperidol]
CTD
PMID:12584149
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Cyp3a9
cytochrome P450, family 3, subfamily a, polypeptide 9
multiple interactions
ISO
CYP3A5 protein results in increased oxidation of and results in increased activity of Haloperidol; Fluoxetine inhibits the reaction [CYP3A5 protein results in increased oxidation of and results in increased activity of Haloperidol]; Fluvoxamine inhibits the reaction [CYP3A5 protein results in increased oxidation of and results in increased activity of Haloperidol]; nefazodone inhibits the reaction [CYP3A5 protein results in increased oxidation of and results in increased activity of Haloperidol]; norfluoxetine inhibits the reaction [CYP3A5 protein results in increased oxidation of and results in increased activity of Haloperidol]; Trazodone inhibits the reaction [CYP3A5 protein results in increased oxidation of and results in increased activity of Haloperidol]
CTD
PMID:12584149
NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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Dcaf6
DDB1 and CUL4 associated factor 6
decreases expression
ISO
Haloperidol results in decreased expression of DCAF6 mRNA
CTD
PMID:14647396
NCBI chr13:77,626,257...77,727,645
Ensembl chr13:77,626,307...77,727,512
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Dclk1
doublecortin-like kinase 1
increases expression
ISO EXP
Haloperidol results in increased expression of DCLK1 mRNA
CTD
PMID:15860345 PMID:18797397
NCBI chr 2:139,417,234...139,710,956
Ensembl chr 2:139,417,163...139,710,956
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Ddx27
DEAD-box helicase 27
increases expression
ISO
Haloperidol results in increased expression of DDX27 protein
CTD
PMID:34122009
NCBI chr 3:155,744,182...155,763,380
Ensembl chr 3:155,744,150...155,763,372
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Ddx46
DEAD-box helicase 46
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of DDX46 protein
CTD
PMID:34122009
NCBI chr17:8,942,070...8,988,440
Ensembl chr17:8,944,454...8,988,439
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Ddx5
DEAD-box helicase 5
decreases expression
ISO
Haloperidol results in decreased expression of DDX5 protein
CTD
PMID:34122009
NCBI chr10:91,723,508...91,732,210
Ensembl chr10:91,723,508...91,732,283
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Dennd10
DENN domain containing 10
increases expression
EXP
Haloperidol results in increased expression of DENND10 mRNA
CTD
PMID:16715494
NCBI chr 1:259,950,955...259,974,459
Ensembl chr 1:259,950,866...259,974,455
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Depp1
DEPP autophagy regulator 1
increases expression
ISO
Haloperidol results in increased expression of DEPP1 mRNA
CTD
PMID:17175557
NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542
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Dgka
diacylglycerol kinase, alpha
decreases expression
EXP
Haloperidol results in decreased expression of DGKA mRNA
CTD
PMID:15860345
NCBI chr 7:1,148,734...1,175,324
Ensembl chr 7:1,148,735...1,175,110
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Dhx36
DEAH-box helicase 36
decreases expression
ISO
Haloperidol results in decreased expression of DHX36 protein
CTD
PMID:34122009
NCBI chr 2:146,856,469...146,894,577
Ensembl chr 2:146,856,469...146,894,572
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Dhx38
DEAH-box helicase 38
decreases expression
ISO
Haloperidol results in decreased expression of DHX38 protein
CTD
PMID:34122009
NCBI chr19:37,512,893...37,530,135
Ensembl chr19:37,512,891...37,530,140
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Dlat
dihydrolipoamide S-acetyltransferase
decreases expression
EXP
Haloperidol results in decreased expression of DLAT mRNA
CTD
PMID:15860345
NCBI chr 8:50,979,151...51,004,435
Ensembl chr 8:50,978,051...51,004,479
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Dlg2
discs large MAGUK scaffold protein 2
increases expression
ISO
Haloperidol results in increased expression of DLG2 protein
CTD
PMID:34122009
NCBI chr 1:144,451,653...146,503,949
Ensembl chr 1:144,451,472...146,499,475
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Dnah1
dynein, axonemal, heavy chain 1
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of DNAH1 protein
CTD
PMID:34122009
NCBI chr16:6,455,514...6,517,103
Ensembl chr16:6,456,002...6,518,350
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Dnah3
dynein, axonemal, heavy chain 3
increases expression
ISO
Haloperidol results in increased expression of DNAH3 protein
CTD
PMID:34122009
NCBI chr 1:174,305,929...174,479,490
Ensembl chr 1:174,306,644...174,479,474
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Dnajb1
DnaJ heat shock protein family (Hsp40) member B1
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of DNAJB1 protein
CTD
PMID:34122009
NCBI chr19:24,522,731...24,526,419
Ensembl chr19:24,522,717...24,526,458
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Dnajb11
DnaJ heat shock protein family (Hsp40) member B11
multiple interactions increases expression
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of DNAJB11 protein Haloperidol results in increased expression of DNAJB11 protein
CTD
PMID:34122009
NCBI chr11:78,151,750...78,168,259
Ensembl chr11:78,150,429...78,180,407
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Dpf1
double PHD fingers 1
increases expression
ISO
Haloperidol results in increased expression of DPF1 mRNA
CTD
PMID:14647396
NCBI chr 1:84,602,212...84,615,954
Ensembl chr 1:84,602,336...84,615,950
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Dr1
down-regulator of transcription 1
decreases expression
ISO
Haloperidol results in decreased expression of DR1 protein
CTD
PMID:34122009
NCBI chr14:1,458,223...1,469,578
Ensembl chr14:1,458,223...1,469,638
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Drd1
dopamine receptor D1
affects binding increases expression decreases expression affects activity
ISO EXP
Haloperidol binds to DRD1 protein Haloperidol results in increased expression of DRD1 protein Haloperidol results in decreased expression of DRD1 mRNA Haloperidol affects the activity of DRD1 protein
CTD
PMID:8750706 PMID:8794996 PMID:12887421 PMID:16983399 PMID:23611293
NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
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Drd2
dopamine receptor D2
affects binding affects activity multiple interactions increases expression affects response to substance
ISO EXP
DRD2 protein binds to Haloperidol; DRD2 protein binds to Haloperidol analog; Haloperidol binds to DRD2 protein Haloperidol affects the activity of DRD2 protein [Haloperidol binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein; cyclo(leucylglycine) inhibits the reaction [Haloperidol results in increased expression of DRD2 protein]; DRD2 protein affects the reaction [Haloperidol results in increased expression of CTNNB1 protein]; DRD2 protein affects the reaction [Haloperidol results in increased expression of DVL3 protein]; DRD2 protein affects the reaction [Haloperidol results in increased expression of GSK3A protein]; DRD2 protein affects the reaction [Haloperidol results in increased expression of GSK3B protein]; felbamate inhibits the reaction [Haloperidol affects the activity of DRD2 protein]; Haloperidol binds to and results in decreased activity of DRD2 protein; Haloperidol inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]; Haloperidol inhibits the reaction [iodosulpride binds to DRD2 protein]; Haloperidol inhibits the reaction [Spiperone binds to DRD2 protein]; Haloperidol promotes the reaction [Dopamine binds to DRD2 protein]; zinc chloride inhibits the reaction [Haloperidol binds to DRD2 protein] Haloperidol results in increased expression of DRD2; Haloperidol results in increased expression of DRD2 mRNA; Haloperidol results in increased expression of DRD2 protein Haloperidol binds to DRD2; Haloperidol binds to DRD2 protein; Haloperidol binds to DRD2 protein alternative form [Haloperidol binds to and results in decreased activity of DRD2 protein] which results in decreased susceptibility to Ethanol; [Haloperidol results in increased expression of DRD2 protein] which results in decreased susceptibility to Pentobarbital; Haloperidol binds to and results in decreased activity of DRD2 protein DRD2 affects the susceptibility to Haloperidol; DRD2 protein affects the susceptibility to Haloperidol Thioctic Acid inhibits the reaction [Haloperidol results in increased expression of DRD2 mRNA]; Thioctic Acid inhibits the reaction [Haloperidol results in increased expression of DRD2 protein]
CTD
PMID:1351265 PMID:1361536 PMID:1380082 PMID:2945998 PMID:7845605 PMID:7878047 PMID:8115415 PMID:8200438 PMID:8794996 PMID:9109525 PMID:9808703 PMID:10720636 PMID:10936494 PMID:11172060 PMID:11927170 PMID:11997696 PMID:12191584 PMID:12476322 PMID:14552778 PMID:15716360 PMID:16033416 PMID:16144542 PMID:18295747 PMID:19120057 PMID:20361897 PMID:20730801 PMID:23611293 More...
NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
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Drd3
dopamine receptor D3
affects binding multiple interactions
ISO EXP
DRD3 protein binds to Haloperidol analog Haloperidol affects the reaction [Methylazoxymethanol Acetate results in increased expression of DRD3 mRNA]
CTD
PMID:14552778 PMID:32360362
NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596
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Drd4
dopamine receptor D4
affects activity affects binding
ISO EXP
Haloperidol affects the activity of DRD4 protein Haloperidol binds to Drd4 protein
CTD RGD
PMID:23611293 PMID:8078498
RGD:7248459
NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553
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Drp2
dystrophin related protein 2
increases expression
EXP
Haloperidol results in increased expression of DRP2 mRNA alternative form
CTD
PMID:16715494
NCBI chr X:97,607,577...97,658,117
Ensembl chr X:97,607,719...97,655,684
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Dtnbp1
dystrobrevin binding protein 1
increases response to substance affects response to substance
ISO
DTNBP1 gene polymorphism results in increased susceptibility to Haloperidol DTNBP1 protein affects the susceptibility to Haloperidol
CTD
PMID:19369910
NCBI chr17:19,685,218...19,776,668
Ensembl chr17:19,685,215...19,776,661
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Dusp1
dual specificity phosphatase 1
decreases expression
EXP
Haloperidol results in decreased expression of DUSP1 mRNA
CTD
PMID:15860345
NCBI chr10:16,680,478...16,683,275
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Dusp6
dual specificity phosphatase 6
decreases expression
EXP
Haloperidol results in decreased expression of DUSP6 mRNA
CTD
PMID:15860345
NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185
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Dvl3
dishevelled segment polarity protein 3
multiple interactions increases expression
EXP
DRD2 protein affects the reaction [Haloperidol results in increased expression of DVL3 protein]
CTD
PMID:16144542
NCBI chr11:80,365,446...80,382,641
Ensembl chr11:80,366,117...80,382,462
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Eef1g
eukaryotic translation elongation factor 1 gamma
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of EEF1G protein
CTD
PMID:34122009
NCBI chr 1:205,860,713...205,871,319
Ensembl chr 1:205,860,698...205,872,382
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Egr1
early growth response 1
affects expression multiple interactions increases expression
EXP ISO
Haloperidol affects the expression of EGR1 protein Haloperidol inhibits the reaction [Methamphetamine results in increased expression of EGR1 mRNA]; OPRM1 protein inhibits the reaction [Haloperidol inhibits the reaction [Methamphetamine results in increased expression of EGR1 mRNA]] Haloperidol results in increased expression of EGR1 mRNA; Haloperidol results in increased expression of EGR1 protein
CTD
PMID:12243769 PMID:16452686 PMID:17028028 PMID:17913375 PMID:18208916 PMID:19695244 PMID:20184921 More...
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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Egr2
early growth response 2
affects expression increases expression decreases expression
ISO EXP
Haloperidol affects the expression of EGR2 mRNA Haloperidol results in increased expression of EGR2 mRNA Haloperidol results in decreased expression of EGR2 protein
CTD
PMID:17028028 PMID:18208916 PMID:19401217
NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562
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Eif2b5
eukaryotic translation initiation factor 2B subunit epsilon
increases expression
ISO
Haloperidol results in increased expression of EIF2B5 protein
CTD
PMID:34122009
NCBI chr11:80,394,433...80,404,468
Ensembl chr11:80,394,433...80,404,419
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Eif5a
eukaryotic translation initiation factor 5A
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of EIF5A protein
CTD
PMID:34122009
NCBI chr10:54,640,104...54,644,845
Ensembl chr10:54,640,024...54,644,656
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Elk1
ETS transcription factor ELK1
increases phosphorylation multiple interactions
ISO EXP
Haloperidol results in increased phosphorylation of ELK1 protein Nifedipine affects the reaction [Haloperidol results in increased phosphorylation of ELK1 protein] SL 327 inhibits the reaction [Haloperidol results in increased phosphorylation of ELK1 protein]
CTD
PMID:12871586 PMID:17913375
NCBI chr X:1,138,826...1,155,713
Ensembl chr X:1,139,756...1,155,713
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Eno1
enolase 1
increases expression
EXP
Haloperidol results in increased expression of ENO1 mRNA
CTD
PMID:15860345
NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
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Epo
erythropoietin
multiple interactions
EXP
EPO protein inhibits the reaction [Haloperidol results in decreased expression of BCL2L1 protein]; EPO protein inhibits the reaction [Haloperidol results in decreased expression of BDNF protein]; EPO protein inhibits the reaction [Haloperidol results in increased expression of CASP3 protein]
CTD
PMID:17805306
NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
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Erap1
endoplasmic reticulum aminopeptidase 1
decreases expression
ISO
Haloperidol results in decreased expression of ERAP1 protein
CTD
PMID:34122009
NCBI chr 2:3,931,817...3,970,735
Ensembl chr 2:3,931,904...3,972,447
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Erbb2
erb-b2 receptor tyrosine kinase 2
multiple interactions
EXP
Haloperidol results in increased expression of and results in increased phosphorylation of ERBB2 protein
CTD
PMID:26961615
NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
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Erbb4
erb-b2 receptor tyrosine kinase 4
increases expression multiple interactions
EXP
Haloperidol results in increased expression of ERBB4 protein Haloperidol results in increased expression of and results in increased phosphorylation of ERBB4 protein
CTD
PMID:18184445 PMID:26961615
NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595
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Ergic1
endoplasmic reticulum-golgi intermediate compartment 1
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of ERGIC1 protein
CTD
PMID:34122009
NCBI chr10:16,531,192...16,626,974
Ensembl chr10:16,531,194...16,626,957
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Ezr
ezrin
decreases expression
ISO
Haloperidol results in decreased expression of EZR protein
CTD
PMID:34122009
NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505
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Fabp3
fatty acid binding protein 3
affects response to substance increases expression
ISO
FABP3 affects the susceptibility to Haloperidol Haloperidol results in increased expression of FABP3 protein
CTD
PMID:20181611 PMID:34122009
NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718
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Fasn
fatty acid synthase
increases expression
ISO
Haloperidol results in increased expression of FASN mRNA
CTD
PMID:16027736
NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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Flt1
Fms related receptor tyrosine kinase 1
decreases expression
ISO
Haloperidol results in decreased expression of FLT1 protein
CTD
PMID:34122009
NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626
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Fndc4
fibronectin type III domain containing 4
increases expression
ISO
Haloperidol results in increased expression of FNDC4 mRNA
CTD
PMID:17175557
NCBI chr 6:25,077,155...25,080,812
Ensembl chr 6:25,077,349...25,080,675
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions increases expression decreases expression
ISO EXP
8-Hydroxy-2-(di-n-propylamino)tetralin affects the reaction [Haloperidol results in increased expression of FOS protein]; Dizocilpine Maleate inhibits the reaction [Haloperidol results in increased expression of FOS protein]; ifenprodil inhibits the reaction [Haloperidol results in increased expression of FOS protein]; tandospirone inhibits the reaction [Haloperidol results in increased expression of FOS protein]; traxoprodil mesylate inhibits the reaction [Haloperidol results in increased expression of FOS protein]; WAY 100135 inhibits the reaction [tandospirone inhibits the reaction [Haloperidol results in increased expression of FOS protein]] Haloperidol results in increased expression of FOS mRNA; Haloperidol results in increased expression of FOS protein Haloperidol results in decreased expression of FOS mRNA; Haloperidol results in decreased expression of FOS protein 8-(3-chlorostyryl)caffeine inhibits the reaction [Haloperidol results in increased expression of FOS mRNA]; 8-Hydroxy-2-(di-n-propylamino)tetralin inhibits the reaction [Haloperidol results in increased expression of FOS mRNA]; Clozapine affects the reaction [Haloperidol results in increased expression of FOS protein]; Dronabinol promotes the reaction [Haloperidol results in increased expression of FOS protein]; Nifedipine affects the reaction [Haloperidol results in increased expression of FOS protein]; Nimodipine affects the reaction [Haloperidol results in increased expression of FOS protein]; Propranolol inhibits the reaction [Haloperidol results in increased expression of FOS protein]; Scopolamine inhibits the reaction [Haloperidol results in increased expression of FOS protein]; Theophylline inhibits the reaction [Haloperidol results in increased expression of FOS mRNA]
CTD
PMID:1393566 PMID:9571656 PMID:9748542 PMID:10199625 PMID:10435392 PMID:11166331 PMID:11409749 PMID:11440804 PMID:11516571 PMID:11602683 PMID:11997696 PMID:12093589 PMID:12125044 PMID:12243769 PMID:12464447 PMID:15120589 PMID:15140647 PMID:17028028 PMID:17913375 PMID:18208916 PMID:18295747 PMID:18521575 PMID:18585397 PMID:18789920 PMID:19352073 PMID:19695244 More...
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Fosb
FosB proto-oncogene, AP-1 transcription factor subunit
increases expression multiple interactions
ISO EXP
Haloperidol results in increased expression of FOSB protein alternative form Haloperidol results in increased expression of FOSB modified form; Haloperidol results in increased expression of FOSB mRNA; Haloperidol results in increased expression of FOSB protein 8-Hydroxy-2-(di-n-propylamino)tetralin inhibits the reaction [Haloperidol results in increased expression of FOSB mRNA]
CTD
PMID:8714707 PMID:11180499 PMID:12243769 PMID:15579174 PMID:19695244 PMID:24067299 More...
NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465
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Fosl1
FOS like 1, AP-1 transcription factor subunit
multiple interactions increases expression
EXP
Amphetamine affects the reaction [Haloperidol results in increased expression of FOSL1 protein] Haloperidol results in increased expression of FOSL1 mRNA; Haloperidol results in increased expression of FOSL1 protein
CTD
PMID:12125044 PMID:18208916
NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
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Fosl2
FOS like 2, AP-1 transcription factor subunit
increases expression
EXP
Haloperidol results in increased expression of FOSL2 mRNA
CTD
PMID:12243769
NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034
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Fyn
FYN proto-oncogene, Src family tyrosine kinase
multiple interactions increases phosphorylation affects response to substance
ISO
FYN gene mutant form inhibits the reaction [Haloperidol results in increased phosphorylation of GRIN2B protein] Haloperidol results in increased phosphorylation of FYN protein FYN protein affects the susceptibility to Haloperidol
CTD
PMID:16407246
NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911
G
Gabra1
gamma-aminobutyric acid type A receptor subunit alpha 1
decreases expression
ISO
Haloperidol results in decreased expression of GABRA1 mRNA
CTD
PMID:18797397
NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
G
Gabrb3
gamma-aminobutyric acid type A receptor subunit beta 3
increases expression
EXP
Haloperidol results in increased expression of GABRB3 mRNA
CTD
PMID:18923069
NCBI chr 1:108,467,047...108,702,522
Ensembl chr 1:108,296,124...108,698,961
G
Gad1
glutamate decarboxylase 1
multiple interactions increases expression decreases expression
EXP
[Haloperidol co-treated with Fluvoxamine] affects the expression of GAD1 protein Haloperidol results in increased expression of GAD1 mRNA Haloperidol results in decreased expression of GAD1 mRNA; Haloperidol results in decreased expression of GAD1 protein
CTD
PMID:12887421 PMID:14519413 PMID:15061247 PMID:15967061 PMID:18923069 PMID:19359144 More...
NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
G
Gad2
glutamate decarboxylase 2
decreases expression increases expression
EXP
Haloperidol results in decreased expression of GAD2 mRNA; Haloperidol results in decreased expression of GAD2 protein Haloperidol results in increased expression of GAD2 mRNA
CTD
PMID:18923069 PMID:19359144
NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155
G
Galnt2
polypeptide N-acetylgalactosaminyltransferase 2
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of GALNT2 protein
CTD
PMID:34122009
NCBI chr19:52,213,226...52,324,816
Ensembl chr19:52,213,351...52,324,813
G
Gapdh
glyceraldehyde-3-phosphate dehydrogenase
increases expression
EXP
Haloperidol results in increased expression of GAPDH mRNA
CTD
PMID:15860345
NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
G
Gda
guanine deaminase
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of GDA protein
CTD
PMID:34122009
NCBI chr 1:218,903,045...218,982,360
Ensembl chr 1:218,906,815...218,982,416
G
Gdpd3
glycerophosphodiester phosphodiesterase domain containing 3
increases expression
ISO
Haloperidol results in increased expression of GDPD3 mRNA
CTD
PMID:17175557
NCBI chr 1:181,373,505...181,383,063
Ensembl chr 1:181,366,626...181,383,063
G
Gfap
glial fibrillary acidic protein
decreases expression
ISO
Haloperidol results in decreased expression of GFAP protein
CTD
PMID:34122009
NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
G
Gimap5
GTPase, IMAP family member 5
decreases expression
EXP
Haloperidol results in decreased expression of GIMAP5 mRNA
CTD
PMID:16715494
NCBI chr 4:77,693,417...77,701,025
Ensembl chr 4:77,687,564...77,703,086
G
Gja1
gap junction protein, alpha 1
decreases expression
EXP
Haloperidol results in decreased expression of GJA1 protein
CTD
PMID:18585900
NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
G
Glo1
glyoxalase 1
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of GLO1 protein
CTD
PMID:34122009
NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649
G
Glul
glutamate-ammonia ligase
decreases expression
EXP
Haloperidol results in decreased expression of GLUL mRNA
CTD
PMID:15860345
NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108
G
Gna12
G protein subunit alpha 12
decreases expression
EXP
Haloperidol results in decreased expression of GNA12 mRNA
CTD
PMID:15860345
NCBI chr12:13,805,580...13,886,255
Ensembl chr12:13,805,698...13,886,255
G
Gnai1
G protein subunit alpha i1
decreases expression
EXP
Haloperidol results in decreased expression of GNAI1 mRNA
CTD
PMID:15860345
NCBI chr 4:16,814,000...16,898,119
Ensembl chr 4:16,814,001...16,896,417
G
Gnai2
G protein subunit alpha i2
decreases expression
EXP
Haloperidol results in decreased expression of GNAI2 mRNA
CTD
PMID:15860345
NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979
G
Gnai3
G protein subunit alpha i3
decreases expression
EXP
Haloperidol results in decreased expression of GNAI3 mRNA
CTD
PMID:15860345
NCBI chr 2:195,742,765...195,780,720
Ensembl chr 2:195,742,642...195,780,742
G
Gnao1
G protein subunit alpha o1
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of GNAO1 protein
CTD
PMID:34122009
NCBI chr19:11,034,874...11,192,531
Ensembl chr19:11,035,956...11,192,493
G
Gnas
GNAS complex locus
decreases expression
EXP
Haloperidol results in decreased expression of GNAS mRNA
CTD
PMID:15860345
NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262 Ensembl chr 3:163,071,417...163,127,262
G
Gnrh1
gonadotropin releasing hormone 1
multiple interactions
EXP
Haloperidol inhibits the reaction [manganese chloride results in increased secretion of GNRH1 protein]
CTD
PMID:18603625
NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581 Ensembl chr15:41,972,905...41,973,581
G
Got2
glutamic-oxaloacetic transaminase 2
affects expression multiple interactions
EXP ISO
Haloperidol affects the expression of GOT2 mRNA [Cuprizone co-treated with Haloperidol] results in increased expression of GOT2 protein
CTD
PMID:15860345 PMID:34122009
NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994
G
Gpx1
glutathione peroxidase 1
increases expression
ISO
Haloperidol results in increased expression of GPX1 mRNA
CTD
PMID:14647396
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
G
Gria1
glutamate ionotropic receptor AMPA type subunit 1
decreases expression
EXP
Haloperidol results in decreased expression of GRIA1 mRNA
CTD
PMID:15860345
NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283
G
Grik2
glutamate ionotropic receptor kainate type subunit 2
increases expression
EXP
Haloperidol results in increased expression of GRIK2 mRNA
CTD
PMID:18923069
NCBI chr20:52,135,325...52,833,061
Ensembl chr20:52,133,851...52,838,375
G
Grik4
glutamate ionotropic receptor kainate type subunit 4
increases expression
EXP
Haloperidol results in increased expression of GRIK4 mRNA
CTD
PMID:15860345
NCBI chr 8:42,903,043...43,331,990
Ensembl chr 8:42,905,056...43,193,751
G
Grik5
glutamate ionotropic receptor kainate type subunit 5
increases expression
ISO EXP
Haloperidol results in increased expression of GRIK5 mRNA
CTD
PMID:14647396 PMID:15860345
NCBI chr 1:80,605,878...80,667,896
Ensembl chr 1:80,605,892...80,667,125
G
Grin1
glutamate ionotropic receptor NMDA type subunit 1
decreases expression increases expression
EXP
Haloperidol results in decreased expression of GRIN1 mRNA Haloperidol results in increased expression of GRIN1 mRNA
CTD
PMID:12020038
NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
G
Grin2a
glutamate ionotropic receptor NMDA type subunit 2A
decreases expression
EXP
Haloperidol results in decreased expression of GRIN2A mRNA; Haloperidol results in decreased expression of GRIN2A protein
CTD
PMID:12608697 PMID:15860345 PMID:18061412
NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637
G
Grin2b
glutamate ionotropic receptor NMDA type subunit 2B
multiple interactions increases phosphorylation
ISO
FYN gene mutant form inhibits the reaction [Haloperidol results in increased phosphorylation of GRIN2B protein]
CTD
PMID:16407246
NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
G
Grin2c
glutamate ionotropic receptor NMDA type subunit 2C
increases expression
EXP
Haloperidol results in increased expression of GRIN2C mRNA
CTD
PMID:15860345
NCBI chr10:100,488,430...100,507,083
Ensembl chr10:100,488,431...100,506,427
G
Grin2d
glutamate ionotropic receptor NMDA type subunit 2D
decreases expression
EXP
Haloperidol results in decreased expression of GRIN2D mRNA
CTD
PMID:18923069
NCBI chr 1:96,306,871...96,346,994
Ensembl chr 1:96,308,365...96,344,793
G
Grin3b
glutamate ionotropic receptor NMDA type subunit 3B
increases expression
EXP
Haloperidol results in increased expression of GRIN3B mRNA
CTD
PMID:15860345
NCBI chr 7:9,730,861...9,737,183
Ensembl chr 7:9,730,862...9,737,183
G
Grk6
G protein-coupled receptor kinase 6
decreases expression
EXP
Haloperidol results in decreased expression of GRK6 mRNA
CTD
PMID:16715494
NCBI chr17:9,177,018...9,192,813
Ensembl chr17:9,177,019...9,192,644
G
Grm1
glutamate metabotropic receptor 1
increases expression
EXP
Haloperidol results in increased expression of GRM1 mRNA
CTD
PMID:15860345
NCBI chr 1:5,058,285...5,453,170
Ensembl chr 1:5,058,292...5,453,170
G
Grm2
glutamate metabotropic receptor 2
increases expression
EXP
Haloperidol results in increased expression of GRM2 mRNA
CTD
PMID:18923069
NCBI chr 8:107,280,099...107,293,159
Ensembl chr 8:107,280,099...107,293,146
G
Gsk3a
glycogen synthase kinase 3 alpha
increases expression multiple interactions
EXP
Haloperidol results in increased expression of GSK3A protein DRD2 protein affects the reaction [Haloperidol results in increased expression of GSK3A protein]
CTD
PMID:16144542
NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802
G
Gsk3b
glycogen synthase kinase 3 beta
multiple interactions increases expression
EXP
DRD2 protein affects the reaction [Haloperidol results in increased expression of GSK3B protein] Haloperidol results in increased expression of GSK3B mRNA; Haloperidol results in increased expression of GSK3B protein
CTD
PMID:16144542 PMID:19359144
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
G
Gstm1
glutathione S-transferase mu 1
increases expression
EXP
Haloperidol results in increased expression of GSTM1 mRNA
CTD
PMID:15860345
NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
G
Gstm2
glutathione S-transferase mu 2
decreases expression
EXP
Haloperidol results in decreased expression of GSTM2 mRNA
CTD
PMID:15860345
NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
G
Gstp1
glutathione S-transferase pi 1
multiple interactions decreases expression
ISO
Haloperidol inhibits the reaction [GSTP1 protein results in decreased susceptibility to Doxorubicin] Haloperidol results in decreased expression of GSTP1 mRNA
CTD
PMID:15946544
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
G
Gtf2e1
general transcription factor IIE subunit 1
decreases expression
ISO
Haloperidol results in decreased expression of GTF2E1 protein
CTD
PMID:34122009
NCBI chr11:63,182,073...63,215,349
Ensembl chr11:63,182,349...63,213,942
G
H2ac18
H2A clustered histone 18
increases expression
ISO
Haloperidol results in increased expression of H2AC18 mRNA
CTD
PMID:14647396
NCBI chr 2:183,808,398...183,808,992
G
H2ac20
H2A clustered histone 20
increases expression
ISO
Haloperidol results in increased expression of H2AC20 protein
CTD
PMID:34122009
NCBI chr 2:183,779,879...183,780,357
G
H2aj
H2A.J histone
increases expression
ISO
Haloperidol results in increased expression of H2AJ protein
CTD
PMID:34122009
NCBI chr 4:169,675,718...169,676,202
Ensembl chr 4:169,675,752...169,677,006
G
Hadhb
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of HADHB protein
CTD
PMID:34122009
NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869
G
Hars1
histidyl-tRNA synthetase 1
increases expression
ISO
Haloperidol results in increased expression of HARS1 protein
CTD
PMID:34122009
NCBI chr18:28,381,649...28,398,699
Ensembl chr18:28,381,655...28,398,740
G
Hcfc1
host cell factor C1
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of HCFC1 protein
CTD
PMID:34122009
NCBI chr X:151,687,779...151,712,688
Ensembl chr X:151,687,779...151,712,638
G
Higd1a
HIG1 hypoxia inducible domain family, member 1A
increases expression
ISO
Haloperidol results in increased expression of HIGD1A mRNA
CTD
PMID:14647396
NCBI chr 8:121,514,152...121,523,382
Ensembl chr 8:121,514,156...121,523,443
G
Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
increases activity increases expression multiple interactions
ISO
Haloperidol results in increased activity of HMGCR protein Haloperidol results in increased expression of HMGCR mRNA [Haloperidol results in increased activity of HMGCR protein] which results in increased abundance of Cholesterol; [Haloperidol results in increased activity of HMGCR protein] which results in increased abundance of Triglycerides
CTD
PMID:16027736 PMID:17052361
NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
G
Hmgcs1
3-hydroxy-3-methylglutaryl-CoA synthase 1
increases expression
ISO
Haloperidol results in increased expression of HMGCS1 mRNA
CTD
PMID:16027736 PMID:17052361
NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
G
Hnrnpc
heterogeneous nuclear ribonucleoprotein C
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of HNRNPC protein
CTD
PMID:34122009
NCBI chr15:24,779,593...24,809,213
Ensembl chr15:24,779,450...24,809,183
G
Hnrnpk
heterogeneous nuclear ribonucleoprotein K
decreases expression
ISO
Haloperidol results in decreased expression of HNRNPK protein
CTD
PMID:34122009
NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997
G
Homer1
homer scaffold protein 1
multiple interactions increases expression
EXP
Cycloserine inhibits the reaction [Haloperidol results in increased expression of HOMER1 mRNA]
CTD
PMID:12464447 PMID:15860345 PMID:20147574
NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785
G
Hpcal4
hippocalcin-like 4
decreases expression
EXP
Haloperidol results in decreased expression of HPCAL4 mRNA
CTD
PMID:12437575
NCBI chr 5:135,454,477...135,466,417
Ensembl chr 5:135,454,540...135,466,416
G
Hsd17b4
hydroxysteroid (17-beta) dehydrogenase 4
decreases expression
ISO
Haloperidol results in decreased expression of HSD17B4 protein
CTD
PMID:34122009
NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952
G
Hspg2
heparan sulfate proteoglycan 2
decreases expression multiple interactions
ISO
Haloperidol results in decreased expression of HSPG2 mRNA HSPG2 gene results in increased susceptibility to [Haloperidol co-treated with Reserpine]
CTD
PMID:20072119
NCBI chr 5:149,677,437...149,778,594
Ensembl chr 5:149,677,476...149,778,594
G
Hsph1
heat shock protein family H (Hsp110) member 1
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of HSPH1 protein
CTD
PMID:34122009
NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224
G
Htr1d
5-hydroxytryptamine receptor 1D
decreases expression
EXP
Haloperidol results in decreased expression of HTR1D mRNA
CTD
PMID:16715494
NCBI chr 5:148,656,252...148,676,532
Ensembl chr 5:148,674,495...148,675,619
G
Htr2a
5-hydroxytryptamine receptor 2A
affects binding multiple interactions
EXP ISO
Haloperidol binds to HTR2A protein [Phencyclidine co-treated with Haloperidol] affects the activity of HTR2A protein
CTD
PMID:7520908 PMID:12191584 PMID:15380371
NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
G
Htr2c
5-hydroxytryptamine receptor 2C
decreases expression
EXP
Haloperidol results in decreased expression of HTR2C mRNA
CTD
PMID:17868938
NCBI chr X:110,640,777...110,870,288
Ensembl chr X:110,641,153...110,870,287
G
Id2
inhibitor of DNA binding 2
decreases expression increases expression
EXP
Haloperidol results in decreased expression of ID2 mRNA Haloperidol results in increased expression of ID2 mRNA
CTD
PMID:12437575
NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
G
Ikbip
IKBKB interacting protein
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of IKBIP protein
CTD
PMID:34122009
NCBI chr 7:25,579,865...25,598,548
Ensembl chr 7:25,579,832...25,605,162
G
Il10
interleukin 10
multiple interactions
ISO
[Cannabidiol co-treated with Haloperidol] results in increased expression of IL10 protein
CTD
PMID:30217539
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
G
Il1b
interleukin 1 beta
multiple interactions increases expression
ISO
Cannabidiol inhibits the reaction [Haloperidol results in increased expression of IL1B protein]
CTD
PMID:30217539
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il6
interleukin 6
increases expression multiple interactions
ISO
Haloperidol results in increased expression of IL6 mRNA Cannabidiol inhibits the reaction [Haloperidol results in increased expression of IL6 mRNA]
CTD
PMID:30217539
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Ilkap
ILK associated serine/threonine phosphatase
decreases expression
EXP
Haloperidol results in decreased expression of ILKAP mRNA
CTD
PMID:15860345
NCBI chr 9:91,966,440...91,988,791
Ensembl chr 9:91,966,441...91,988,892
G
Impdh1
inosine monophosphate dehydrogenase 1
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of IMPDH1 protein
CTD
PMID:34122009
NCBI chr 4:57,801,842...57,817,434
Ensembl chr 4:57,801,831...57,819,076
G
Inha
inhibin subunit alpha
decreases expression
EXP
Haloperidol results in decreased expression of INHA mRNA
CTD
PMID:16715494
NCBI chr 9:76,994,465...76,997,366
Ensembl chr 9:76,993,589...76,997,248
G
Inhbe
inhibin subunit beta E
increases expression
ISO
Haloperidol results in increased expression of INHBE mRNA
CTD
PMID:17175557
NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172
G
Jun
Jun proto-oncogene, AP-1 transcription factor subunit
increases expression decreases expression
EXP
Haloperidol results in increased expression of JUN mRNA; Haloperidol results in increased expression of JUN protein Haloperidol results in decreased expression of JUN mRNA
CTD
PMID:12093589 PMID:12125044 PMID:15860345 PMID:18208916
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
G
Junb
JunB proto-oncogene, AP-1 transcription factor subunit
multiple interactions increases expression decreases expression
EXP
8-Hydroxy-2-(di-n-propylamino)tetralin inhibits the reaction [Haloperidol results in increased expression of JUNB mRNA] Haloperidol results in decreased expression of JUNB mRNA
CTD
PMID:12093589 PMID:19695244
NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
G
Kcna1
potassium voltage-gated channel subfamily A member 1
increases expression
ISO
Haloperidol results in increased expression of KCNA1 mRNA; Haloperidol results in increased expression of KCNA1 protein
CTD
PMID:18797397
NCBI chr 4:159,464,223...159,472,905
Ensembl chr 4:159,464,188...159,472,682
G
Kcnab1
potassium voltage-gated channel subfamily A regulatory beta subunit 1
decreases expression
ISO
Haloperidol results in decreased expression of KCNAB1 mRNA
CTD
PMID:18797397
NCBI chr 2:149,137,025...149,603,540
Ensembl chr 2:149,137,041...149,603,534
G
Kcnh2
potassium voltage-gated channel subfamily H member 2
multiple interactions decreases activity
ISO
Haloperidol inhibits the reaction [KCNH2 protein results in increased transport of Thallium] Haloperidol results in decreased activity of KCNH2 protein
CTD
PMID:15671647 PMID:16278312 PMID:16494862 PMID:19583963 PMID:21158687
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
G
Kcnip3
potassium voltage-gated channel interacting protein 3
decreases expression
ISO
Haloperidol results in decreased expression of KCNIP3 mRNA; Haloperidol results in decreased expression of KCNIP3 protein
CTD
PMID:18797397
NCBI chr 3:114,677,027...114,742,923
Ensembl chr 3:114,677,030...114,743,556
G
Kdm1a
lysine demethylase 1A
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of KDM1A protein
CTD
PMID:34122009
NCBI chr 5:148,782,976...148,838,319
Ensembl chr 5:148,782,976...148,838,319
G
Kdr
kinase insert domain receptor
increases expression
ISO
Haloperidol results in increased expression of KDR protein
CTD
PMID:34122009
NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
G
Kif5c
kinesin family member 5C
decreases expression
ISO
Haloperidol results in decreased expression of KIF5C protein
CTD
PMID:34122009
NCBI chr 3:34,032,082...34,185,597
Ensembl chr 3:34,032,105...34,182,413
G
Kiz
kizuna centrosomal protein
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of KIZ protein
CTD
PMID:34122009
NCBI chr 3:134,277,631...134,385,260
Ensembl chr 3:134,277,687...134,385,190
G
Klc1
kinesin light chain 1
decreases expression
ISO
Haloperidol results in decreased expression of KLC1 mRNA
CTD
PMID:18797397
NCBI chr 6:130,823,416...130,866,729
Ensembl chr 6:130,823,419...130,867,031
G
Klc4
kinesin light chain 4
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of KLC4 protein
CTD
PMID:34122009
NCBI chr 9:14,337,164...14,351,075
Ensembl chr 9:14,337,534...14,351,066
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Klhdc2
kelch domain containing 2
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of KLHDC2 protein
CTD
PMID:34122009
NCBI chr 6:87,777,183...87,791,609
Ensembl chr 6:87,777,183...87,804,187
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Kmt2a
lysine methyltransferase 2A
decreases expression
ISO
Haloperidol results in decreased expression of KMT2A mRNA
CTD
PMID:14647396
NCBI chr 8:45,116,763...45,193,320
Ensembl chr 8:45,118,814...45,193,181
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Kpna4
karyopherin subunit alpha 4
increases expression
ISO
Haloperidol results in increased expression of KPNA4 protein
CTD
PMID:34122009
NCBI chr 2:153,319,380...153,381,085
Ensembl chr 2:153,324,273...153,381,081
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Kras
KRAS proto-oncogene, GTPase
increases expression
EXP
Haloperidol results in increased expression of KRAS mRNA
CTD
PMID:15860345
NCBI chr 4:178,185,418...178,218,484
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Kremen1
kringle containing transmembrane protein 1
multiple interactions increases expression
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of KREMEN1 protein Haloperidol results in increased expression of KREMEN1 protein
CTD
PMID:34122009
NCBI chr14:80,081,870...80,147,489
Ensembl chr14:80,084,403...80,147,516
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Lamtor3
late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
increases expression
ISO
Haloperidol results in increased expression of LAMTOR3 mRNA
CTD
PMID:14647396
NCBI chr 2:226,411,389...226,423,612
Ensembl chr 2:226,411,400...226,423,607
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Ldhb
lactate dehydrogenase B
decreases expression increases expression
ISO EXP
Haloperidol results in decreased expression of LDHB mRNA Haloperidol results in increased expression of LDHB mRNA
CTD
PMID:15860345 PMID:16465460
NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403
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Ldlr
low density lipoprotein receptor
increases expression
ISO
Haloperidol results in increased expression of LDLR mRNA
CTD
PMID:17052361
NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
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Lgals1
galectin 1
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of LGALS1 protein
CTD
PMID:34122009
NCBI chr 7:110,485,239...110,488,345
Ensembl chr 7:110,481,392...110,488,345
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Lipa
lipase A, lysosomal acid type
increases expression
ISO
Haloperidol results in increased expression of LIPA protein
CTD
PMID:34122009
NCBI chr 1:232,024,351...232,057,735
Ensembl chr 1:232,024,356...232,057,633
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Mag
myelin-associated glycoprotein
decreases expression
ISO
Haloperidol results in decreased expression of MAG mRNA
CTD
PMID:17177202
NCBI chr 1:86,148,227...86,163,726
Ensembl chr 1:86,148,228...86,163,656
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Map1a
microtubule-associated protein 1A
increases expression decreases expression
EXP ISO
Haloperidol results in increased expression of MAP1A mRNA Haloperidol results in decreased expression of MAP1A protein
CTD
PMID:15860345 PMID:34122009
NCBI chr 3:108,263,217...108,283,936
Ensembl chr 3:108,263,151...108,282,899
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Map2
microtubule-associated protein 2
increases expression
EXP
Haloperidol results in increased expression of MAP2 mRNA
CTD
PMID:15079866
NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809
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Map2k1
mitogen activated protein kinase kinase 1
decreases expression
EXP
Haloperidol results in decreased expression of MAP2K1 mRNA
CTD
PMID:15860345
NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
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Map2k2
mitogen activated protein kinase kinase 2
decreases expression increases expression
EXP ISO
Haloperidol results in decreased expression of MAP2K2 mRNA Haloperidol results in increased expression of MAP2K2 mRNA
CTD
PMID:14647396 PMID:15860345
NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
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Map2k5
mitogen activated protein kinase kinase 5
decreases expression
EXP
Haloperidol results in decreased expression of MAP2K5 mRNA
CTD
PMID:15860345
NCBI chr 8:63,625,220...63,852,090
Ensembl chr 8:63,625,221...63,851,983
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Map3k1
mitogen-activated protein kinase kinase kinase 1
increases expression
EXP
Haloperidol results in increased expression of MAP3K1 mRNA
CTD
PMID:15860345
NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463
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Map3k12
mitogen activated protein kinase kinase kinase 12
increases expression
EXP
Haloperidol results in increased expression of MAP3K12 mRNA
CTD
PMID:15860345
NCBI chr 7:133,630,267...133,648,464
Ensembl chr 7:133,630,835...133,640,789
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Mapk1
mitogen activated protein kinase 1
increases phosphorylation decreases expression multiple interactions
ISO EXP
Haloperidol results in increased phosphorylation of MAPK1 protein Haloperidol results in decreased expression of MAPK1 mRNA [potassium perchlorate co-treated with 2-mercapto-1-methylimidazole] inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK1 protein]; Clozapine inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK1 protein]; CNR1 protein affects the reaction [[potassium perchlorate co-treated with 2-mercapto-1-methylimidazole] inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK1 protein]]; SL 327 inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK1 protein]
CTD
PMID:12871586 PMID:15860345 PMID:28017790
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk14
mitogen activated protein kinase 14
affects expression
EXP
Haloperidol affects the expression of MAPK14 mRNA
CTD
PMID:15860345
NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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Mapk3
mitogen activated protein kinase 3
increases phosphorylation multiple interactions
ISO
Haloperidol results in increased phosphorylation of MAPK3 protein [potassium perchlorate co-treated with 2-mercapto-1-methylimidazole] inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK3 protein]; Clozapine inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK3 protein]; CNR1 protein affects the reaction [[potassium perchlorate co-treated with 2-mercapto-1-methylimidazole] inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK3 protein]]; SL 327 inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK3 protein]
CTD
PMID:12871586 PMID:28017790
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mapk6
mitogen-activated protein kinase 6
affects expression
EXP
Haloperidol affects the expression of MAPK6 mRNA
CTD
PMID:15860345
NCBI chr 8:76,146,650...76,169,767
Ensembl chr 8:76,146,690...76,169,720
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Mapk8
mitogen-activated protein kinase 8
increases phosphorylation
EXP
Haloperidol results in increased phosphorylation of MAPK8 protein
CTD
PMID:17092607
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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Mapk9
mitogen-activated protein kinase 9
affects expression
EXP
Haloperidol affects the expression of MAPK9 mRNA
CTD
PMID:15860345
NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
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Mapre1
microtubule-associated protein, RP/EB family, member 1
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of MAPRE1 protein
CTD
PMID:34122009
NCBI chr 3:142,218,846...142,246,990
Ensembl chr 3:142,212,955...142,246,983
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Mas1
MAS1 proto-oncogene, G protein-coupled receptor
decreases expression
EXP
Haloperidol results in decreased expression of MAS1 mRNA
CTD
PMID:16715494
NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709
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Mbp
myelin basic protein
decreases expression
ISO
Haloperidol results in decreased expression of MBP mRNA
CTD
PMID:17177202
NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404
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Mcam
melanoma cell adhesion molecule
increases expression
ISO
Haloperidol results in increased expression of MCAM protein
CTD
PMID:34122009
NCBI chr 8:44,479,391...44,487,575
Ensembl chr 8:44,479,376...44,487,571
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Mchr1
melanin-concentrating hormone receptor 1
affects binding
ISO
Haloperidol binds to MCHR1 protein
CTD
PMID:16983399
NCBI chr 7:112,761,554...112,764,746
Ensembl chr 7:112,761,554...112,764,032
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Mmp10
matrix metallopeptidase 10
decreases expression
ISO
Haloperidol results in decreased expression of MMP10 protein
CTD
PMID:34122009
NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748
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Mog
myelin oligodendrocyte glycoprotein
decreases expression
ISO
Haloperidol results in decreased expression of MOG mRNA
CTD
PMID:17177202
NCBI chr20:1,513,137...1,523,473
Ensembl chr20:1,513,239...1,523,474
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Mrps31
mitochondrial ribosomal protein S31
increases expression
ISO
Haloperidol results in increased expression of MRPS31 protein
CTD
PMID:34122009
NCBI chr16:69,601,349...69,621,609
Ensembl chr16:69,601,349...69,630,654
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Myadm
myeloid-associated differentiation marker
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of MYADM protein
CTD
PMID:34122009
NCBI chr 1:65,864,180...65,874,701
Ensembl chr 1:65,864,173...65,874,035
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Myo5b
myosin Vb
decreases expression
ISO
Haloperidol results in decreased expression of MYO5B protein
CTD
PMID:34122009
NCBI chr18:68,038,759...68,341,568
Ensembl chr18:68,038,759...68,338,745
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Nap1l3
nucleosome assembly protein 1-like 3
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of NAP1L3 protein
CTD
PMID:34122009
NCBI chr X:88,347,595...88,350,393
Ensembl chr X:88,347,598...88,350,393
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Ncan
neurocan
decreases expression
ISO
Haloperidol results in decreased expression of NCAN mRNA
CTD
PMID:18797397
NCBI chr16:19,301,969...19,328,436
Ensembl chr16:19,301,969...19,328,436
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Ncaph
non-SMC condensin I complex, subunit H
decreases expression
ISO
Haloperidol results in decreased expression of NCAPH protein
CTD
PMID:34122009
NCBI chr 3:114,371,937...114,399,178
Ensembl chr 3:114,371,941...114,399,180
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Ncl
nucleolin
increases expression
ISO
Haloperidol results in increased expression of NCL mRNA
CTD
PMID:14647396
NCBI chr 9:86,999,588...87,008,112
Ensembl chr 9:86,998,019...87,008,136
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Ndufv1
NADH:ubiquinone oxidoreductase core subunit V1
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of NDUFV1 protein
CTD
PMID:34122009
NCBI chr 1:201,300,365...201,305,461
Ensembl chr 1:201,299,985...201,305,466
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Nedd4
NEDD4 E3 ubiquitin protein ligase
decreases expression
ISO
Haloperidol results in decreased expression of NEDD4 mRNA
CTD
PMID:18797397
NCBI chr 8:73,384,095...73,468,951
Ensembl chr 8:73,383,695...73,468,951
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Nfkb1
nuclear factor kappa B subunit 1
decreases expression
EXP
Haloperidol results in decreased expression of NFKB1 protein
CTD
PMID:16500086
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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Ngfr
nerve growth factor receptor
decreases expression
EXP
Haloperidol results in decreased expression of NGFR mRNA
CTD
PMID:16513140
NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
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Nifk
nucleolar protein interacting with the FHA domain of MKI67
decreases expression
ISO
Haloperidol results in decreased expression of NIFK protein
CTD
PMID:34122009
NCBI chr13:29,393,303...29,403,387
Ensembl chr13:29,393,286...29,405,896
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Nop14
NOP14 nucleolar protein
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of NOP14 protein
CTD
PMID:34122009
NCBI chr14:76,081,313...76,102,454
Ensembl chr14:76,080,793...76,102,453
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Nop53
NOP53 ribosome biogenesis factor
increases expression
ISO
Haloperidol results in increased expression of NOP53 mRNA
CTD
PMID:14647396
NCBI chr 1:76,629,084...76,636,902
Ensembl chr 1:76,629,069...76,636,902
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Nos2
nitric oxide synthase 2
multiple interactions increases expression
ISO
Cannabidiol inhibits the reaction [Haloperidol results in increased expression of NOS2 mRNA]
CTD
PMID:30217539
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Nppa
natriuretic peptide A
affects activity
EXP
Haloperidol affects the activity of NPPA protein modified form
CTD
PMID:1363893
NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
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Nptx2
neuronal pentraxin 2
decreases expression
EXP
Haloperidol results in decreased expression of NPTX2 mRNA
CTD
PMID:18208916
NCBI chr12:10,037,435...10,048,345
Ensembl chr12:10,037,435...10,048,345
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Npy
neuropeptide Y
multiple interactions increases expression decreases expression
EXP
Haloperidol promotes the reaction [Amphetamine results in decreased expression of NPY protein] Haloperidol results in increased expression of NPY protein Haloperidol results in decreased expression of NPY mRNA
CTD
PMID:7644023 PMID:15985714 PMID:16516965
NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
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Nqo1
NAD(P)H quinone dehydrogenase 1
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of NQO1 protein
CTD
PMID:34122009
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Nr0b2
nuclear receptor subfamily 0, group B, member 2
increases expression
ISO
Haloperidol results in increased expression of NR0B2 mRNA
CTD
PMID:17175557
NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
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Nr1d1
nuclear receptor subfamily 1, group D, member 1
increases expression
EXP
Haloperidol results in increased expression of NR1D1 mRNA
CTD
PMID:11564422
NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705
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Nr4a1
nuclear receptor subfamily 4, group A, member 1
affects response to substance multiple interactions increases expression decreases expression
ISO EXP
NR4A1 affects the susceptibility to Haloperidol 8-Hydroxy-2-(di-n-propylamino)tetralin inhibits the reaction [Haloperidol results in increased expression of NR4A1 mRNA] Haloperidol results in decreased expression of NR4A1 mRNA
CTD
PMID:10987852 PMID:11564422 PMID:14603264 PMID:19695244
NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
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Nr4a3
nuclear receptor subfamily 4, group A, member 3
increases expression
EXP
Haloperidol results in increased expression of NR4A3 mRNA
CTD
PMID:19695244
NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733
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Nrg1
neuregulin 1
increases expression
EXP
Haloperidol results in increased expression of NRG1 protein
CTD
PMID:18184445 PMID:26961615
NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884
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Nsf
N-ethylmaleimide sensitive factor, vesicle fusing ATPase
decreases expression
EXP ISO
Haloperidol results in decreased expression of NSF mRNA Haloperidol results in decreased expression of NSF protein
CTD
PMID:15860345 PMID:34122009
NCBI chr10:88,727,912...88,857,375
Ensembl chr10:88,727,912...88,857,386
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Nts
neurotensin
multiple interactions increases expression
ISO EXP
SLC6A3 protein promotes the reaction [Haloperidol results in increased expression of NTS mRNA] Haloperidol results in increased expression of NTS mRNA; Haloperidol results in increased expression of NTS protein 8-(3-chlorostyryl)caffeine inhibits the reaction [Haloperidol results in increased expression of NTS mRNA]; Theophylline inhibits the reaction [Haloperidol results in increased expression of NTS mRNA]
CTD
PMID:10199625 PMID:11120399 PMID:11602683 PMID:12887421 PMID:14603264 PMID:14698760 More...
NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423
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Numbl
NUMB-like, endocytic adaptor protein
decreases expression
ISO
Haloperidol results in decreased expression of NUMBL mRNA
CTD
PMID:18797397
NCBI chr 1:82,549,814...82,573,788
Ensembl chr 1:82,550,054...82,573,776
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Nup54
nucleoporin 54
decreases expression
ISO
Haloperidol results in decreased expression of NUP54 protein
CTD
PMID:34122009
NCBI chr14:15,617,630...15,636,029
Ensembl chr14:15,617,679...15,636,028
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Nupr1
nuclear protein 1, transcriptional regulator
increases expression
ISO
Haloperidol results in increased expression of NUPR1 mRNA
CTD
PMID:17175557
NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281
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Oat
ornithine aminotransferase
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of OAT protein
CTD
PMID:34122009
NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682
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Oprl1
opioid related nociceptin receptor 1
affects response to substance
ISO
OPRL1 affects the susceptibility to Haloperidol
CTD
PMID:16237164
NCBI chr 3:168,831,934...168,839,920
Ensembl chr 3:168,834,003...168,839,920
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Oprm1
opioid receptor, mu 1
multiple interactions
ISO
OPRM1 protein inhibits the reaction [Haloperidol inhibits the reaction [Methamphetamine results in increased expression of EGR1 mRNA]]
CTD
PMID:20184921
NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
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Osbpl8
oxysterol binding protein-like 8
increases expression
ISO
Haloperidol results in increased expression of OSBPL8 mRNA
CTD
PMID:14647396
NCBI chr 7:46,596,944...46,749,888
Ensembl chr 7:46,596,983...46,749,888
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Park7
Parkinsonism associated deglycase
increases expression
ISO
Haloperidol results in increased expression of PARK7 mRNA
CTD
PMID:14647396
NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
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Pcmt1
protein-L-isoaspartate (D-aspartate) O-methyltransferase 1
decreases expression
ISO
Haloperidol results in decreased expression of PCMT1 protein
CTD
PMID:34122009
NCBI chr 1:2,111,756...2,160,354
Ensembl chr 1:2,111,763...2,159,201
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Pcsk1n
proprotein convertase subtilisin/kexin type 1 inhibitor
increases expression
ISO
Haloperidol results in increased expression of PCSK1N mRNA
CTD
PMID:14647396
NCBI chr X:14,580,036...14,583,478
Ensembl chr X:14,580,038...14,583,566
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Pde10a
phosphodiesterase 10A
increases expression
EXP
Haloperidol results in increased expression of PDE10A mRNA; Haloperidol results in increased expression of PDE10A protein
CTD
PMID:18222493
NCBI chr 1:51,765,743...52,218,086
Ensembl chr 1:51,770,132...52,216,563
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Pde1b
phosphodiesterase 1B
increases expression
EXP ISO
Haloperidol results in increased expression of PDE1B mRNA; Haloperidol results in increased expression of PDE1B protein
CTD
PMID:14647396 PMID:18222493
NCBI chr 7:134,627,378...134,654,581
Ensembl chr 7:134,627,322...134,654,580
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Pde4a
phosphodiesterase 4A
decreases expression
EXP
Haloperidol results in decreased expression of PDE4A protein
CTD
PMID:20222156
NCBI chr 8:19,690,816...19,753,538
Ensembl chr 8:19,703,290...19,751,961
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Pdlim5
PDZ and LIM domain 5
decreases expression
ISO
Haloperidol results in decreased expression of PDLIM5 protein
CTD
PMID:34122009
NCBI chr 2:230,952,251...231,120,329
Ensembl chr 2:230,952,248...231,120,275
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Pdzrn3
PDZ domain containing RING finger 3
decreases expression
ISO
Haloperidol results in decreased expression of PDZRN3 protein
CTD
PMID:34122009
NCBI chr 4:133,770,736...133,996,959
Ensembl chr 4:133,770,736...133,996,959
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Penk
proenkephalin
multiple interactions increases expression
ISO EXP
3,4-dicarboxyphenylglycine promotes the reaction [Haloperidol results in increased expression of PENK mRNA]; Docosahexaenoic Acids inhibits the reaction [Haloperidol results in increased expression of PENK mRNA]; Tretinoin inhibits the reaction [Haloperidol results in increased expression of PENK mRNA] Haloperidol results in increased expression of PENK mRNA; Haloperidol results in increased expression of PENK protein 1-aminocyclopentane-1,2,4-tricarboxylic acid inhibits the reaction [Haloperidol results in increased expression of PENK mRNA]; 1-aminoindan-1,5-dicarboxylic acid inhibits the reaction [Haloperidol results in increased expression of PENK mRNA]; 2-(2,3-dicarboxycyclopropyl)glycine promotes the reaction [Haloperidol results in increased expression of PENK mRNA]; 5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine inhibits the reaction [Haloperidol results in increased expression of PENK mRNA]; 6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Haloperidol results in increased expression of PENK mRNA]; Memantine inhibits the reaction [Haloperidol results in increased expression of PENK mRNA]; Scopolamine inhibits the reaction [Haloperidol results in increased expression of PENK mRNA]
CTD
PMID:3838946 PMID:7637876 PMID:12373537 PMID:12727308 PMID:12834887 PMID:12887421 PMID:14603264 PMID:14642644 PMID:15215559 PMID:17224239 More...
NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129
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Per1
period circadian regulator 1
increases expression
ISO
Haloperidol results in increased expression of PER1 mRNA
CTD
PMID:27746588
NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431
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Pfdn5
prefoldin subunit 5
increases expression
ISO
Haloperidol results in increased expression of PFDN5 mRNA
CTD
PMID:14647396
NCBI chr 7:133,451,778...133,456,516
Ensembl chr 7:133,451,453...133,456,516
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Pfkp
phosphofructokinase, platelet
increases expression multiple interactions
EXP ISO
Haloperidol results in increased expression of PFKP mRNA [Cuprizone co-treated with Haloperidol] results in increased expression of PFKP protein
CTD
PMID:15860345 PMID:34122009
NCBI chr17:63,729,743...63,794,026
Ensembl chr17:63,729,780...63,794,018
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Pfn1
profilin 1
increases expression
ISO
Haloperidol results in increased expression of PFN1 protein
CTD
PMID:34122009
NCBI chr10:55,365,263...55,367,968
Ensembl chr10:55,365,262...55,527,631
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Pgk1
phosphoglycerate kinase 1
increases expression
EXP
Haloperidol results in increased expression of PGK1 mRNA
CTD
PMID:15860345
NCBI chr X:71,271,454...71,287,429
Ensembl chr X:71,271,440...71,287,418
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Phactr1
phosphatase and actin regulator 1
increases expression
ISO
Haloperidol results in increased expression of PHACTR1 mRNA
CTD
PMID:14647396
NCBI chr17:21,560,364...22,040,166
Ensembl chr17:21,562,721...22,039,831
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Picalm
phosphatidylinositol binding clathrin assembly protein
decreases expression
EXP
Haloperidol results in decreased expression of PICALM mRNA
CTD
PMID:15860345
NCBI chr 1:144,056,415...144,138,045
Ensembl chr 1:144,056,721...144,137,557
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Pik3r3
phosphoinositide-3-kinase regulatory subunit 3
decreases expression
EXP
Haloperidol results in decreased expression of PIK3R3 mRNA
CTD
PMID:16715494
NCBI chr 5:129,700,925...129,772,591
Ensembl chr 5:129,701,229...129,772,583
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Pkib
cAMP-dependent protein kinase inhibitor beta
decreases expression
EXP
Haloperidol results in decreased expression of PKIB mRNA
CTD
PMID:15860345
NCBI chr20:36,965,172...37,062,190
Ensembl chr20:36,905,340...37,062,187
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Pkm
pyruvate kinase M1/2
increases expression
EXP
Haloperidol results in increased expression of PKM mRNA
CTD
PMID:15860345
NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
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Plp1
proteolipid protein 1
decreases expression
ISO
Haloperidol results in decreased expression of PLP1 mRNA
CTD
PMID:17177202 PMID:18797397
NCBI chr X:100,184,039...100,201,035
Ensembl chr X:100,185,767...100,201,032
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Plpbp
pyridoxal phosphate binding protein
increases expression
ISO
Haloperidol results in increased expression of PLPBP protein
CTD
PMID:34122009
NCBI chr16:65,003,292...65,014,886
Ensembl chr16:65,002,223...65,014,886
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Pls3
plastin 3
decreases expression
ISO
Haloperidol results in decreased expression of PLS3 protein
CTD
PMID:34122009
NCBI chr X:111,589,193...111,683,908
Ensembl chr X:111,589,254...111,683,891
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Pmpca
peptidase, mitochondrial processing subunit alpha
increases expression
ISO
Haloperidol results in increased expression of PMPCA protein
CTD
PMID:34122009
NCBI chr 3:9,207,731...9,216,846
Ensembl chr 3:9,207,717...9,216,844
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Ppa1
inorganic pyrophosphatase 1
increases expression
ISO
Haloperidol results in increased expression of PPA1 protein
CTD
PMID:34122009
NCBI chr20:29,590,733...29,617,711
Ensembl chr20:29,590,707...29,619,215
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Ppargc1a
PPARG coactivator 1 alpha
multiple interactions
ISO
[Cannabidiol co-treated with Haloperidol] results in increased expression of PPARGC1A protein
CTD
PMID:30217539
NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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Ppm1a
protein phosphatase, Mg2+/Mn2+ dependent, 1A
decreases expression
EXP
Haloperidol results in decreased expression of PPM1A mRNA
CTD
PMID:15860345
NCBI chr 6:91,439,094...91,486,139
Ensembl chr 6:91,438,834...91,480,697
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Ppm1b
protein phosphatase, Mg2+/Mn2+ dependent, 1B
decreases expression
EXP
Haloperidol results in decreased expression of PPM1B mRNA
CTD
PMID:15860345
NCBI chr 6:9,646,695...9,707,471
Ensembl chr 6:9,655,765...9,707,974
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Ppm1f
protein phosphatase, Mg2+/Mn2+ dependent, 1F
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of PPM1F protein
CTD
PMID:34122009
NCBI chr11:84,064,422...84,094,410
Ensembl chr11:84,064,420...84,094,340
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Ppp1cb
protein phosphatase 1 catalytic subunit beta
decreases expression
EXP
Haloperidol results in decreased expression of PPP1CB mRNA
CTD
PMID:15860345
NCBI chr 6:23,958,813...23,992,841
Ensembl chr 6:23,960,998...23,992,824
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Ppp1cc
protein phosphatase 1 catalytic subunit gamma
decreases expression
EXP
Haloperidol results in decreased expression of PPP1CC mRNA
CTD
PMID:15860345
NCBI chr12:34,383,072...34,400,553
Ensembl chr12:34,383,072...34,400,553
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Ppp1r14b
protein phosphatase 1, regulatory (inhibitor) subunit 14B
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of PPP1R14B protein
CTD
PMID:34122009
NCBI chr 1:204,165,210...204,167,320
Ensembl chr 1:204,163,299...204,167,319
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Ppp1r1a
protein phosphatase 1, regulatory (inhibitor) subunit 1A
decreases expression
EXP
Haloperidol results in decreased expression of PPP1R1A mRNA
CTD
PMID:15860345
NCBI chr 7:134,654,578...134,662,236
Ensembl chr 7:134,654,579...134,662,230
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Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
increases phosphorylation
ISO
Haloperidol results in increased phosphorylation of PPP1R1B protein
CTD
PMID:12871586
NCBI chr10:83,347,731...83,356,775
Ensembl chr10:83,347,731...83,356,775
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Ppp1r2
protein phosphatase 1, regulatory (inhibitor) subunit 2
decreases expression
EXP
Haloperidol results in decreased expression of PPP1R2 mRNA
CTD
PMID:15860345
NCBI chr11:69,472,676...69,494,468
Ensembl chr11:69,472,555...69,494,463
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Ppp1r9b
protein phosphatase 1, regulatory subunit 9B
decreases expression
EXP
Haloperidol results in decreased expression of PPP1R9B protein
CTD
PMID:16844384
NCBI chr10:79,938,055...79,954,085
Ensembl chr10:79,938,066...79,954,083
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Ppp2ca
protein phosphatase 2 catalytic subunit alpha
decreases expression
EXP
Haloperidol results in decreased expression of PPP2CA mRNA
CTD
PMID:15860345
NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862
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Ppp2cb
protein phosphatase 2 catalytic subunit beta
decreases expression
EXP
Haloperidol results in decreased expression of PPP2CB mRNA
CTD
PMID:15860345
NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576
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Ppp2r1a
protein phosphatase 2 scaffold subunit A alpha
increases expression
EXP
Haloperidol results in increased expression of PPP2R1A mRNA
CTD
PMID:15860345
NCBI chr 1:60,540,223...60,559,467
Ensembl chr 1:60,540,194...60,560,129
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Ppp2r2a
protein phosphatase 2, regulatory subunit B, alpha
decreases expression
EXP
Haloperidol results in decreased expression of PPP2R2A mRNA
CTD
PMID:15860345
NCBI chr15:41,204,659...41,263,924
Ensembl chr15:41,204,200...41,263,924
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Ppp3ca
protein phosphatase 3 catalytic subunit alpha
multiple interactions decreases expression
EXP
[Haloperidol binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein Haloperidol results in decreased expression of PPP3CA mRNA; Haloperidol results in decreased expression of PPP3CA protein
CTD
PMID:16033416
NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974
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Ppp5c
protein phosphatase 5, catalytic subunit
decreases expression multiple interactions
ISO
Haloperidol results in decreased expression of PPP5C mRNA [Cuprizone co-treated with Haloperidol] results in decreased expression of PPP5C protein
CTD
PMID:14647396 PMID:34122009
NCBI chr 1:77,690,203...77,714,507
Ensembl chr 1:77,690,208...77,714,456
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Prkaca
protein kinase cAMP-activated catalytic subunit alpha
increases expression
EXP
Haloperidol results in increased expression of PRKACA mRNA
CTD
PMID:15860345
NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430
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Prkacb
protein kinase cAMP-activated catalytic subunit beta
increases expression
EXP
Haloperidol results in increased expression of PRKACB mRNA
CTD
PMID:15860345
NCBI chr 2:235,636,878...235,726,928
Ensembl chr 2:235,636,885...235,726,198
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Prkar2a
protein kinase cAMP-dependent type II regulatory subunit alpha
multiple interactions increases expression
EXP ISO
Haloperidol promotes the reaction [Cyclic AMP binds to PRKAR2A protein] [Cuprizone co-treated with Haloperidol] results in decreased expression of PRKAR2A protein Haloperidol results in increased expression of PRKAR2A mRNA; Haloperidol results in increased expression of PRKAR2A protein
CTD
PMID:11907174 PMID:34122009
NCBI chr 8:109,393,189...109,458,832
Ensembl chr 8:109,395,833...109,455,628
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Prkar2b
protein kinase cAMP-dependent type II regulatory subunit beta
multiple interactions increases expression decreases expression
EXP
Haloperidol promotes the reaction [Cyclic AMP binds to PRKAR2B protein] Haloperidol results in increased expression of PRKAR2B mRNA; Haloperidol results in increased expression of PRKAR2B protein Haloperidol results in decreased expression of PRKAR2B mRNA
CTD
PMID:11907174 PMID:15860345
NCBI chr 6:48,563,659...48,653,933
Ensembl chr 6:48,563,662...48,653,933
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Prkcb
protein kinase C, beta
multiple interactions increases expression
EXP
[Haloperidol co-treated with Fluvoxamine] affects the expression of PRKCB protein Haloperidol results in increased expression of PRKCB mRNA
CTD
PMID:15860345 PMID:15967061
NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
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Prkce
protein kinase C, epsilon
increases expression
EXP
Haloperidol results in increased expression of PRKCE mRNA
CTD
PMID:15860345
NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719
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Prkcsh
PRKCSH beta subunit of glucosidase II
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of PRKCSH protein
CTD
PMID:34122009
NCBI chr 8:20,534,787...20,546,493
Ensembl chr 8:20,534,880...20,546,492
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Prkcz
protein kinase C, zeta
increases expression
EXP
Haloperidol results in increased expression of PRKCZ mRNA
CTD
PMID:15860345
NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367
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Prl
prolactin
affects expression increases secretion multiple interactions increases expression
ISO EXP
Haloperidol affects the expression of PRL protein Haloperidol results in increased secretion of PRL protein Haloperidol inhibits the reaction [Aripiprazole results in decreased secretion of PRL protein]; Haloperidol inhibits the reaction [Bromocriptine results in decreased secretion of PRL protein]; Haloperidol inhibits the reaction [cabergoline results in decreased secretion of PRL protein]; Haloperidol inhibits the reaction [Dopamine results in decreased secretion of PRL protein]; Haloperidol inhibits the reaction [talipexole results in decreased secretion of PRL protein]; LHRH, N-acetyl-(4-chlorophenylalanyl)(1)-(4-chlorophenylalanyl)(2)-tryptophyl(3)-arginyl(6)-alanine(10)- inhibits the reaction [Haloperidol results in increased expression of PRL protein]; Triptorelin Pamoate inhibits the reaction [Haloperidol results in increased expression of PRL protein]
CTD
PMID:1304992 PMID:1380082 PMID:2136057 PMID:3019639 PMID:3158510 PMID:3883215 PMID:3906589 PMID:7018927 PMID:7214106 PMID:7348089 PMID:7670571 PMID:8613910 PMID:8915564 PMID:9090331 PMID:9128918 PMID:9265911 PMID:9265916 PMID:9376336 PMID:9572212 PMID:10661492 PMID:11048906 PMID:11071396 PMID:11997696 PMID:15289996 PMID:15638391 PMID:16282852 PMID:18521575 More...
NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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Prpf19
pre-mRNA processing factor 19
increases expression
ISO
Haloperidol results in increased expression of PRPF19 protein
CTD
PMID:34122009
NCBI chr 1:207,541,582...207,552,664
Ensembl chr 1:207,541,595...207,552,662
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Prpf38b
pre-mRNA processing factor 38B
decreases expression
ISO
Haloperidol results in decreased expression of PRPF38B mRNA
CTD
PMID:14647396
NCBI chr 2:196,553,224...196,562,271
Ensembl chr 2:196,553,225...196,562,250
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Prrc2a
proline-rich coiled-coil 2A
decreases expression
ISO
Haloperidol results in decreased expression of PRRC2A mRNA
CTD
PMID:18797397
NCBI chr20:3,658,391...3,674,143
Ensembl chr20:3,658,695...3,674,130
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Prxl2a
peroxiredoxin like 2A
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of PRXL2A protein
CTD
PMID:34122009
NCBI chr16:16,866,601...16,886,378
Ensembl chr16:16,866,603...16,886,433
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Psmb9
proteasome 20S subunit beta 9
decreases expression
EXP
Haloperidol results in decreased expression of PSMB9 mRNA
CTD
PMID:16452686
NCBI chr20:4,667,044...4,672,512
Ensembl chr20:4,666,046...4,672,512
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Psmd12
proteasome 26S subunit, non-ATPase 12
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of PSMD12 protein
CTD
PMID:34122009
NCBI chr10:92,438,223...92,457,323
Ensembl chr10:92,438,298...92,457,287
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Ptgs2
prostaglandin-endoperoxide synthase 2
increases expression
ISO
Haloperidol results in increased expression of PTGS2 mRNA
CTD
PMID:30217539
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Ptma
prothymosin alpha
increases expression
ISO
Haloperidol results in increased expression of PTMA protein
CTD
PMID:34122009
NCBI chr 9:87,176,251...87,180,333
Ensembl chr 9:87,176,230...87,180,333
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Ptms
parathymosin
increases expression
ISO
Haloperidol results in increased expression of PTMS mRNA
CTD
PMID:14647396
NCBI chr 4:157,722,384...157,726,575
Ensembl chr 4:157,722,386...157,727,009
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Pura
purine rich element binding protein A
increases expression
ISO
Haloperidol results in increased expression of PURA protein
CTD
PMID:34122009
NCBI chr18:27,885,071...27,905,509
Ensembl chr18:27,884,556...27,905,513
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Purb
purine rich element binding protein B
decreases expression
ISO
Haloperidol results in decreased expression of PURB protein
CTD
PMID:34122009
NCBI chr14:81,342,374...81,344,857
Ensembl chr14:81,336,448...81,351,432
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Pvalb
parvalbumin
multiple interactions
EXP
Haloperidol inhibits the reaction [Phencyclidine results in decreased expression of PVALB mRNA]
CTD
PMID:12589379
NCBI chr 7:109,772,939...109,787,954
Ensembl chr 7:109,772,593...109,784,561
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Pycr1
pyrroline-5-carboxylate reductase 1
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of PYCR1 protein
CTD
PMID:34122009
NCBI chr10:105,917,732...105,922,658
Ensembl chr10:105,917,680...105,922,549
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Pygm
glycogen phosphorylase, muscle associated
decreases expression
ISO
Haloperidol results in decreased expression of PYGM protein
CTD
PMID:34122009
NCBI chr 1:203,690,550...203,705,369
Ensembl chr 1:203,690,533...203,705,368
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Qki
QKI, KH domain containing RNA binding
increases expression
ISO
Haloperidol results in increased expression of QKI mRNA alternative form
CTD
PMID:19335891
NCBI chr 1:50,387,716...50,501,568
Ensembl chr 1:50,387,698...50,498,831
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Rab10
RAB10, member RAS oncogene family
increases expression
EXP
Haloperidol results in increased expression of RAB10 mRNA
CTD
PMID:15860345
NCBI chr 6:26,267,081...26,319,739
Ensembl chr 6:26,266,859...26,320,193
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Rab11a
RAB11a, member RAS oncogene family
increases expression
EXP
Haloperidol results in increased expression of RAB11A mRNA
CTD
PMID:15860345
NCBI chr 8:65,223,698...65,246,461
Ensembl chr 8:65,222,949...65,246,525
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Rab12
RAB12, member RAS oncogene family
increases expression
EXP
Haloperidol results in increased expression of RAB12 mRNA
CTD
PMID:12437575
NCBI chr 9:106,480,301...106,506,895
Ensembl chr 9:106,480,301...106,506,910
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Rab28
RAB28, member RAS oncogene family
increases expression
EXP
Haloperidol results in increased expression of RAB28 mRNA
CTD
PMID:15860345
NCBI chr14:69,245,846...69,322,968
Ensembl chr14:69,245,854...69,322,967
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Rab4a
RAB4A, member RAS oncogene family
decreases expression
EXP
Haloperidol results in decreased expression of RAB4A mRNA
CTD
PMID:15860345
NCBI chr19:51,795,613...51,822,706
Ensembl chr19:51,795,613...51,822,703
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Rab5a
RAB5A, member RAS oncogene family
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of RAB5A protein
CTD
PMID:34122009
NCBI chr 9:6,483,906...6,512,877
Ensembl chr 9:6,484,469...6,512,873
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Rab6a
RAB6A, member RAS oncogene family
increases expression
EXP
Haloperidol results in increased expression of RAB6A mRNA
CTD
PMID:15860345
NCBI chr 1:154,957,870...155,008,922
Ensembl chr 1:154,958,189...154,996,715
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Rab7a
RAB7A, member RAS oncogene family
decreases expression
EXP
Haloperidol results in decreased expression of RAB7A mRNA
CTD
PMID:15860345
NCBI chr 4:120,461,966...120,510,756
Ensembl chr 4:120,461,963...120,506,889
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Rab8a
RAB8A, member RAS oncogene family
decreases expression
EXP
Haloperidol results in decreased expression of RAB8A mRNA
CTD
PMID:15860345
NCBI chr16:17,654,027...17,675,385
Ensembl chr16:17,654,034...17,675,678
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Rac1
Rac family small GTPase 1
increases expression
EXP
Haloperidol results in increased expression of RAC1 mRNA
CTD
PMID:15860345
NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
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Rala
RAS like proto-oncogene A
increases expression
EXP
Haloperidol results in increased expression of RALA mRNA
CTD
PMID:15860345
NCBI chr17:47,092,163...47,145,192
Ensembl chr17:47,092,207...47,144,063
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Ralb
RAS like proto-oncogene B
increases expression
EXP
Haloperidol results in increased expression of RALB mRNA
CTD
PMID:15860345
NCBI chr13:30,588,036...30,624,199
Ensembl chr13:30,588,033...30,624,202
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Ranbp3
RAN binding protein 3
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of RANBP3 protein
CTD
PMID:34122009
NCBI chr 9:1,507,233...1,544,460
Ensembl chr 9:1,507,361...1,544,460
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Rap1b
RAP1B, member of RAS oncogene family
increases expression
EXP
Haloperidol results in increased expression of RAP1B mRNA
CTD
PMID:15860345
NCBI chr 7:53,423,039...53,456,349
Ensembl chr 7:53,423,130...53,456,370
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Rapgef4
Rap guanine nucleotide exchange factor 4
decreases expression
ISO
Haloperidol results in decreased expression of RAPGEF4 mRNA
CTD
PMID:18797397
NCBI chr 3:56,809,388...57,101,332
Ensembl chr 3:56,809,270...57,102,316
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Rarb
retinoic acid receptor, beta
increases expression
EXP
Haloperidol results in increased expression of RARB mRNA alternative form
CTD
PMID:11564422
NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288
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Rasgrf1
RAS protein-specific guanine nucleotide-releasing factor 1
affects localization
EXP
Haloperidol affects the localization of RASGRF1 protein
CTD
PMID:17092607
NCBI chr 8:90,445,154...90,574,274
Ensembl chr 8:90,445,154...90,574,269
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Rasgrp1
RAS guanyl releasing protein 1
decreases expression
EXP
Haloperidol results in decreased expression of RASGRP1 mRNA
CTD
PMID:15860345
NCBI chr 3:104,168,549...104,230,107
Ensembl chr 3:104,170,013...104,230,056
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Rcn1
reticulocalbin 1
multiple interactions decreases expression
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of RCN1 protein Haloperidol results in decreased expression of RCN1 protein
CTD
PMID:34122009
NCBI chr 3:91,841,052...91,855,295
Ensembl chr 3:91,841,052...91,855,295
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Rdh11
retinol dehydrogenase 11
decreases expression
ISO
Haloperidol results in decreased expression of RDH11 protein
CTD
PMID:34122009
NCBI chr 6:97,979,377...97,995,252
Ensembl chr 6:97,979,378...97,995,252
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Rdx
radixin
decreases expression
ISO
Haloperidol results in decreased expression of RDX protein
CTD
PMID:34122009
NCBI chr 8:52,379,494...52,437,673
Ensembl chr 8:52,379,494...52,437,678
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Rela
RELA proto-oncogene, NF-kB subunit
increases expression
EXP
Haloperidol results in increased expression of RELA protein
CTD
PMID:18554768 PMID:18590723
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Reln
reelin
decreases expression
EXP
Haloperidol results in decreased expression of RELN mRNA; Haloperidol results in decreased expression of RELN protein
CTD
PMID:19359144
NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211
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Rgs2
regulator of G-protein signaling 2
increases expression
EXP
Haloperidol results in increased expression of RGS2 mRNA
CTD
PMID:11409749 PMID:11516571
NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385
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Rgs4
regulator of G-protein signaling 4
increases expression
EXP
Haloperidol results in increased expression of RGS4 mRNA
CTD
PMID:15860345
NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068
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Rgs8
regulator of G-protein signaling 8
increases expression
EXP
Haloperidol results in increased expression of RGS8 mRNA
CTD
PMID:15860345
NCBI chr13:65,804,703...65,848,955
Ensembl chr13:65,804,797...65,846,807
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Rgs9
regulator of G-protein signaling 9
affects response to substance
ISO
RGS9 affects the susceptibility to Haloperidol
CTD
PMID:15728856
NCBI chr10:94,195,265...94,270,892
Ensembl chr10:94,197,054...94,270,892
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Rhoa
ras homolog family member A
decreases expression
EXP
Haloperidol results in decreased expression of RHOA mRNA
CTD
PMID:15860345
NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
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Rims1
regulating synaptic membrane exocytosis 1
decreases expression
EXP
Haloperidol results in decreased expression of RIMS1 mRNA
CTD
PMID:15860345
NCBI chr 9:24,696,959...25,196,404
Ensembl chr 9:24,698,854...25,196,631
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Rorb
RAR-related orphan receptor B
decreases expression
EXP
Haloperidol results in decreased expression of RORB mRNA
CTD
PMID:11564422
NCBI chr 1:216,363,629...216,544,390
Ensembl chr 1:216,363,629...216,544,390
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Rpl13
ribosomal protein L13
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of RPL13 protein
CTD
PMID:34122009
NCBI chr19:51,153,990...51,156,541
Ensembl chr19:51,153,924...51,163,014
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Rpl18a
ribosomal protein L18A
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of RPL18A protein
CTD
PMID:34122009
NCBI chr16:18,542,555...18,544,578
Ensembl chr16:18,542,566...18,545,546
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Rpl19
ribosomal protein L19
decreases expression multiple interactions
ISO
Haloperidol results in decreased expression of RPL19 protein [Cuprizone co-treated with Haloperidol] results in increased expression of RPL19 protein
CTD
PMID:34122009
NCBI chr10:83,022,503...83,026,030
Ensembl chr10:83,019,257...83,052,112
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Rpl30
ribosomal protein L30
increases expression
ISO
Haloperidol results in increased expression of RPL30 protein
CTD
PMID:34122009
NCBI chr 7:65,648,266...65,651,401
Ensembl chr 7:65,645,991...65,651,363 Ensembl chr10:65,645,991...65,651,363 Ensembl chr10:65,645,991...65,651,363
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Rpl6
ribosomal protein L6
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of RPL6 protein
CTD
PMID:34122009
NCBI chr12:35,347,493...35,352,011
Ensembl chr12:35,347,497...35,351,921
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Rpl8
ribosomal protein L8
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of RPL8 protein
CTD
PMID:34122009
NCBI chr 7:108,626,194...108,628,485
Ensembl chr 7:108,622,324...108,628,482 Ensembl chr 3:108,622,324...108,628,482
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Rplp0l1
ribosomal protein lateral stalk subunit P0 like 1
decreases expression
ISO
Haloperidol results in decreased expression of RPLP0P6 protein
CTD
PMID:34122009
NCBI chr 2:191,921,503...191,922,661
Ensembl chr 2:191,921,574...191,922,646
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Rplp2
ribosomal protein lateral stalk subunit P2
increases expression
ISO
Haloperidol results in increased expression of RPLP2 mRNA
CTD
PMID:14647396
NCBI chr 1:196,546,086...196,548,636
Ensembl chr 1:196,546,352...196,548,645
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Rps10
ribosomal protein S10
increases expression
ISO
Haloperidol results in increased expression of RPS10 mRNA
CTD
PMID:14647396
NCBI chr20:5,694,313...5,698,922
Ensembl chr20:5,694,313...5,699,044 Ensembl chr 6:5,694,313...5,699,044
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Rps16
ribosomal protein S16
decreases expression
ISO
Haloperidol results in decreased expression of RPS16 protein
CTD
PMID:34122009
NCBI chr 1:83,643,066...83,646,056
Ensembl chr 1:83,643,130...83,646,206
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Rps27
ribosomal protein S27
increases expression
ISO
Haloperidol results in increased expression of RPS27 protein
CTD
PMID:34122009
NCBI chr 2:175,665,858...175,666,963
Ensembl chr 2:175,665,853...175,666,964
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Rps27a
ribosomal protein S27a
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of RPS27A protein
CTD
PMID:34122009
NCBI chr14:103,285,734...103,288,011
Ensembl chr14:103,285,734...103,288,011 Ensembl chr 5:103,285,734...103,288,011
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Rps9
ribosomal protein S9
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of RPS9 protein
CTD
PMID:34122009
NCBI chr 1:65,511,723...65,515,076
Ensembl chr 1:65,511,723...65,515,123
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Rrad
RRAD, Ras related glycolysis inhibitor and calcium channel regulator
increases expression
EXP
Haloperidol results in increased expression of RRAD mRNA
CTD
PMID:15860345
NCBI chr19:354,184...357,424
Ensembl chr19:354,198...357,417
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Rrbp1
ribosome binding protein 1
decreases expression
ISO
Haloperidol results in decreased expression of RRBP1 protein
CTD
PMID:34122009
NCBI chr 3:131,314,996...131,376,930
Ensembl chr 3:131,314,998...131,376,981
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Rsf1
remodeling and spacing factor 1
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of RSF1 protein
CTD
PMID:34122009
NCBI chr 1:151,892,055...152,015,089
Ensembl chr 1:151,892,434...152,009,051
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Rtn4
reticulon 4
decreases expression
ISO
Haloperidol results in decreased expression of RTN4 mRNA
CTD
PMID:18797397
NCBI chr14:103,450,074...103,497,687
Ensembl chr14:103,449,930...103,497,686
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Rxrg
retinoid X receptor gamma
affects response to substance increases expression
ISO EXP
RXRG protein affects the susceptibility to Haloperidol Haloperidol results in increased expression of RXRG mRNA alternative form
CTD
PMID:10336693 PMID:11564422
NCBI chr13:79,743,430...79,785,173
Ensembl chr13:79,743,563...79,785,167
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S100a9
S100 calcium binding protein A9
decreases expression
ISO
Haloperidol results in decreased expression of S100A9 mRNA
CTD
PMID:18797397
NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
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Sae1
SUMO1 activating enzyme subunit 1
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of SAE1 protein
CTD
PMID:34122009
NCBI chr 1:77,030,961...77,086,937
Ensembl chr 1:77,030,965...77,086,986
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Sars1
seryl-tRNA synthetase 1
decreases expression
ISO
Haloperidol results in decreased expression of SARS1 protein
CTD
PMID:34122009
NCBI chr 2:196,065,543...196,081,240
Ensembl chr 2:196,065,430...196,081,277
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Satb2
SATB homeobox 2
decreases expression
ISO
Haloperidol results in decreased expression of SATB2 protein
CTD
PMID:34122009
NCBI chr 9:58,348,027...58,534,256
Ensembl chr 9:58,350,246...58,530,707
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Sbds
Sbds, ribosome maturation factor
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of SBDS protein
CTD
PMID:34122009
NCBI chr12:26,420,410...26,429,650
Ensembl chr12:26,420,414...26,429,649
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Sc5d
sterol-C5-desaturase
increases expression
ISO
Haloperidol results in increased expression of SC5D mRNA
CTD
PMID:17052361
NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273
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Scd
stearoyl-CoA desaturase
increases expression
ISO
Haloperidol results in increased expression of SCD mRNA
CTD
PMID:16027736
NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
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Sec61a1
SEC61 translocon subunit alpha 1
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of SEC61A1 protein
CTD
PMID:34122009
NCBI chr 4:120,973,519...120,987,871
Ensembl chr 4:120,960,626...120,987,925
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Sec63
SEC63 homolog, protein translocation regulator
increases expression
ISO
Haloperidol results in increased expression of SEC63 protein
CTD
PMID:34122009
NCBI chr20:46,245,101...46,314,055
Ensembl chr20:46,245,101...46,314,055
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Serpina3n
serine (or cysteine) peptidase inhibitor, clade A, member 3N
increases expression
ISO
Haloperidol results in increased expression of SERPINA3 mRNA; Haloperidol results in increased expression of SERPINA3 protein
CTD
PMID:17175557 PMID:34122009
NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433
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Serpini1
serpin family I member 1
decreases expression
ISO
Haloperidol results in decreased expression of SERPINI1 mRNA
CTD
PMID:18797397
NCBI chr 2:160,346,403...160,433,135
Ensembl chr 2:160,346,758...160,433,135
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Sf3b4
splicing factor 3B subunit 4
decreases expression
ISO
Haloperidol results in decreased expression of SF3B4 protein
CTD
PMID:34122009
NCBI chr 2:183,732,791...183,737,545
Ensembl chr 2:183,732,754...183,737,959
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Sgcd
sarcoglycan, delta
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of SGCD protein
CTD
PMID:34122009
NCBI chr10:31,346,480...32,328,364
Ensembl chr10:31,280,511...31,724,840
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Sgk1
serum/glucocorticoid regulated kinase 1
increases expression
EXP
Haloperidol results in increased expression of SGK1 mRNA
CTD
PMID:16452686
NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
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Sh3kbp1
SH3 domain-containing kinase-binding protein 1
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of SH3KBP1 protein
CTD
PMID:34122009
NCBI chr X:34,877,862...35,223,013
Ensembl chr X:34,877,866...35,222,747
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Sh3pxd2b
SH3 and PX domains 2B
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of SH3PXD2B protein
CTD
PMID:34122009
NCBI chr10:16,918,611...17,027,499
Ensembl chr10:16,918,679...17,005,170
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Slc17a6
solute carrier family 17 member 6
increases expression
ISO
Haloperidol results in increased expression of SLC17A6 mRNA; Haloperidol results in increased expression of SLC17A6 protein
CTD
PMID:18155072
NCBI chr 1:101,212,489...101,252,543
Ensembl chr 1:101,212,489...101,252,542
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Slc17a8
solute carrier family 17 member 8
affects response to substance
ISO
SLC17A8 protein affects the susceptibility to Haloperidol
CTD
PMID:18278042
NCBI chr 7:23,994,212...24,049,498
Ensembl chr 7:23,994,217...24,048,079
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Slc18a2
solute carrier family 18 member A2
affects binding
ISO
Haloperidol binds to SLC18A2 protein
CTD
PMID:7912402
NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325
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Slc1a1
solute carrier family 1 member 1
decreases expression
EXP
Haloperidol results in decreased expression of SLC1A1 mRNA
CTD
PMID:12873733
NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402
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Slc1a2
solute carrier family 1 member 2
decreases expression
EXP
Haloperidol results in decreased expression of SLC1A2 mRNA
CTD
PMID:12873733
NCBI chr 3:89,005,129...89,135,469
Ensembl chr 3:89,005,129...89,126,498
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Slc1a3
solute carrier family 1 member 3
decreases expression
EXP
Haloperidol results in decreased expression of SLC1A3 mRNA
CTD
PMID:15860345
NCBI chr 2:57,755,495...57,830,605
Ensembl chr 2:57,755,497...57,830,605
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Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Haloperidol inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]
CTD
PMID:23770354
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Slc25a3
solute carrier family 25 member 3
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of SLC25A3 protein
CTD
PMID:34122009
NCBI chr 7:25,611,937...25,619,401
Ensembl chr 7:25,586,725...25,667,727
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Slc2a4
solute carrier family 2 member 4
increases expression
ISO
Haloperidol results in increased expression of SLC2A4 mRNA
CTD
PMID:16002093
NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
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Slc39a7
solute carrier family 39 member 7
increases expression
ISO
Haloperidol results in increased expression of SLC39A7 mRNA
CTD
PMID:14647396
NCBI chr20:4,823,166...4,826,538
Ensembl chr20:4,822,012...4,826,537
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Slc6a3
solute carrier family 6 member 3
multiple interactions increases expression
ISO EXP
SLC6A3 protein promotes the reaction [Haloperidol results in increased expression of NTS mRNA] Haloperidol results in increased expression of SLC6A3 protein
CTD
PMID:14698760 PMID:17069804
NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
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Slc6a4
solute carrier family 6 member 4
increases expression
EXP
Haloperidol results in increased expression of SLC6A4
CTD
PMID:12007678
NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
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Snap25
synaptosome associated protein 25
affects response to substance affects expression
ISO EXP
SNAP25 gene SNP affects the susceptibility to Haloperidol Haloperidol affects the expression of SNAP25 mRNA
CTD
PMID:15823421 PMID:15860345
NCBI chr 3:124,041,898...124,123,761
Ensembl chr 3:124,041,898...124,123,760
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Snrpd2
small nuclear ribonucleoprotein D2 polypeptide
increases expression
ISO
Haloperidol results in increased expression of SNRPD2 mRNA
CTD
PMID:14647396
NCBI chr 1:78,798,377...78,801,227
Ensembl chr 1:78,798,377...78,803,351
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Sod1
superoxide dismutase 1
increases expression decreases expression multiple interactions
EXP
Haloperidol results in increased expression of SOD1 mRNA Haloperidol results in decreased expression of SOD1 protein Clozapine inhibits the reaction [Haloperidol results in decreased expression of SOD1 protein]; Haloperidol results in decreased activity of and results in decreased expression of SOD1 protein; olanzapine inhibits the reaction [Haloperidol results in decreased expression of SOD1 protein]; Risperidone inhibits the reaction [Haloperidol results in decreased expression of SOD1 protein]
CTD
PMID:12482469 PMID:12752374 PMID:16564057
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Sod2
superoxide dismutase 2
decreases expression multiple interactions
EXP
Haloperidol results in decreased expression of SOD2 mRNA; Haloperidol results in decreased expression of SOD2 protein Haloperidol results in decreased activity of and results in decreased expression of SOD2 protein
CTD
PMID:12482469 PMID:15860345 PMID:16564057
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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Sod3
superoxide dismutase 3
increases expression
EXP
Haloperidol results in increased expression of SOD3 mRNA
CTD
PMID:15860345
NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990
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Speg
striated muscle enriched protein kinase
increases expression
ISO
Haloperidol results in increased expression of SPEG protein
CTD
PMID:34122009
NCBI chr 9:76,865,714...76,923,170
Ensembl chr 9:76,865,754...76,923,144
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Srebf2
sterol regulatory element binding transcription factor 2
multiple interactions
ISO
Haloperidol results in increased cleavage of and results in increased activity of SREBF2 protein
CTD
PMID:17052361
NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848
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Srpra
SRP receptor subunit alpha
decreases expression
ISO
Haloperidol results in decreased expression of SRPRA protein
CTD
PMID:34122009
NCBI chr 8:33,560,365...33,566,458
Ensembl chr 8:33,560,348...33,566,470
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Srsf2
serine and arginine rich splicing factor 2
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of SRSF2 protein
CTD
PMID:34122009
NCBI chr10:102,052,158...102,055,365
Ensembl chr10:102,052,314...102,055,338
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Srsf5
serine and arginine rich splicing factor 5
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of SRSF5 protein
CTD
PMID:34122009
NCBI chr 6:100,605,165...100,610,192
Ensembl chr 6:100,605,456...100,610,177
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Stip1
stress-induced phosphoprotein 1
decreases expression
ISO
Haloperidol results in decreased expression of STIP1 protein
CTD
PMID:34122009
NCBI chr 1:204,209,433...204,228,452
Ensembl chr 1:204,178,932...204,228,476
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Strn4
striatin 4
increases expression
ISO
Haloperidol results in increased expression of STRN4 mRNA
CTD
PMID:14647396
NCBI chr 1:77,482,267...77,511,862
Ensembl chr 1:77,482,094...77,511,858
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Stt3a
STT3 oligosaccharyltransferase complex catalytic subunit A
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of STT3A protein
CTD
PMID:34122009
NCBI chr 8:36,443,623...36,483,111
Ensembl chr 8:36,446,788...36,483,293
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Stx1a
syntaxin 1A
increases expression
EXP
Haloperidol results in increased expression of STX1A mRNA
CTD
PMID:15860345
NCBI chr12:21,641,971...21,670,022
Ensembl chr12:21,641,969...21,669,930
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Stx1b
syntaxin 1B
affects expression
EXP
Haloperidol affects the expression of STX1B mRNA
CTD
PMID:15860345
NCBI chr 1:182,415,544...182,434,385
Ensembl chr 1:182,415,546...182,441,280
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Stx4
syntaxin 4
increases expression
EXP
Haloperidol results in increased expression of STX4 mRNA
CTD
PMID:15860345
NCBI chr 1:182,451,108...182,459,701
Ensembl chr 1:182,451,117...182,459,979
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Stx5
syntaxin 5
decreases expression
EXP
Haloperidol results in decreased expression of STX5 mRNA
CTD
PMID:15860345
NCBI chr 1:205,637,401...205,653,563
Ensembl chr 1:205,637,413...205,653,563
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Stx7
syntaxin 7
decreases expression
EXP
Haloperidol results in decreased expression of STX7 mRNA
CTD
PMID:15860345
NCBI chr 1:21,197,075...21,237,320
Ensembl chr 1:21,197,075...21,237,279
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Stx8
syntaxin 8
affects expression
EXP
Haloperidol affects the expression of STX8 mRNA
CTD
PMID:15860345
NCBI chr10:52,655,643...52,900,048
Ensembl chr10:52,654,990...52,894,993
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Supt3h
SPT3 homolog, SAGA and STAGA complex component
increases expression
EXP
Haloperidol results in increased expression of SUPT3H mRNA
CTD
PMID:16715494
NCBI chr 9:15,878,296...16,206,768
Ensembl chr 9:15,868,287...16,206,706
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Syn2
synapsin II
increases expression
EXP
Haloperidol results in increased expression of SYN2 mRNA
CTD
PMID:15860345
NCBI chr 4:148,178,846...148,347,010
Ensembl chr 4:148,186,270...148,344,192
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Sypl1
synaptophysin-like 1
decreases expression
ISO
Haloperidol results in decreased expression of SYPL1 mRNA
CTD
PMID:18797397
NCBI chr 6:49,565,111...49,585,205
Ensembl chr 6:49,565,154...49,585,330
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Syt11
synaptotagmin 11
increases expression
EXP
Haloperidol results in increased expression of SYT11 mRNA
CTD
PMID:15860345
NCBI chr 2:174,206,032...174,232,540
Ensembl chr 2:174,206,191...174,231,964
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Syt3
synaptotagmin 3
decreases expression
EXP
Haloperidol results in decreased expression of SYT3 mRNA
CTD
PMID:15860345
NCBI chr 1:94,880,835...94,895,518
Ensembl chr 1:94,881,247...94,895,246
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Syt4
synaptotagmin 4
affects expression
EXP
Haloperidol affects the expression of SYT4 mRNA
CTD
PMID:15860345
NCBI chr18:23,036,973...23,046,380
Ensembl chr18:23,038,378...23,046,332
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Tac1
tachykinin, precursor 1
increases expression
EXP
Haloperidol results in increased expression of TAC1 mRNA
CTD
PMID:10974607
NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
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Tagln
transgelin
decreases expression
ISO
Haloperidol results in decreased expression of TAGLN mRNA
CTD
PMID:17175557
NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668
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Tagln2
transgelin 2
decreases expression
ISO
Haloperidol results in decreased expression of TAGLN2 protein
CTD
PMID:34122009
NCBI chr13:84,966,980...84,973,973
Ensembl chr13:84,967,009...84,973,972
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Tap1
transporter 1, ATP binding cassette subfamily B member
decreases expression
EXP
Haloperidol results in decreased expression of TAP1 mRNA
CTD
PMID:16452686
NCBI chr20:4,656,262...4,666,634
Ensembl chr20:4,656,263...4,666,901
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Tatdn1
TatD DNase domain containing 1
increases expression
ISO
Haloperidol results in increased expression of TATDN1 mRNA
CTD
PMID:14647396
NCBI chr 7:90,449,979...90,481,000
Ensembl chr 7:90,441,079...90,481,133
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Tcaf1
TRPM8 channel-associated factor 1
decreases expression
ISO
Haloperidol results in decreased expression of TCAF1 protein
CTD
PMID:34122009
NCBI chr 4:71,589,674...71,639,274
Ensembl chr 4:71,591,200...71,613,309
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Tcerg1
transcription elongation regulator 1
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of TCERG1 protein
CTD
PMID:34122009
NCBI chr18:34,505,708...34,566,470
Ensembl chr18:34,505,751...34,566,470
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Tf
transferrin
decreases expression
ISO
Haloperidol results in decreased expression of TRF mRNA
CTD
PMID:17177202
NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
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Tgoln2
trans-golgi network protein 2
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of TGOLN2 protein
CTD
PMID:34122009
NCBI chr 4:104,663,356...104,671,208
Ensembl chr 4:104,663,353...104,671,164
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Th
tyrosine hydroxylase
increases expression
EXP
Haloperidol results in increased expression of TH protein
CTD
PMID:17028028
NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
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Thra
thyroid hormone receptor alpha
decreases expression increases expression
EXP
Haloperidol results in decreased expression of THRA mRNA alternative form Haloperidol results in increased expression of THRA mRNA alternative form
CTD
PMID:11564422
NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
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Tln2
talin 2
decreases expression
ISO
Haloperidol results in decreased expression of TLN2 protein
CTD
PMID:34122009
NCBI chr 8:67,830,920...68,252,240
Ensembl chr 8:67,834,326...68,252,219
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Tm9sf2
transmembrane 9 superfamily member 2
decreases expression
ISO
Haloperidol results in decreased expression of TM9SF2 protein
CTD
PMID:34122009
NCBI chr15:99,201,556...99,254,054
Ensembl chr15:99,201,489...99,254,049
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Tmem109
transmembrane protein 109
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of TMEM109 protein
CTD
PMID:34122009
NCBI chr 1:207,519,628...207,530,245
Ensembl chr 1:207,519,624...207,530,215
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Tmod3
tropomodulin 3
decreases expression
ISO
Haloperidol results in decreased expression of TMOD3 protein
CTD
PMID:34122009
NCBI chr 8:76,248,978...76,310,855
Ensembl chr 8:76,248,979...76,310,977
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Tmprss2
transmembrane serine protease 2
increases expression
EXP
Haloperidol results in increased expression of TMPRSS2 mRNA
CTD
PMID:32808185
NCBI chr11:36,934,306...36,973,779
Ensembl chr11:36,934,306...36,973,715
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Tnf
tumor necrosis factor
multiple interactions increases expression
EXP ISO
Haloperidol affects the reaction [Phencyclidine affects the expression of TNF mRNA] Cannabidiol inhibits the reaction [Haloperidol results in increased expression of TNF mRNA] Haloperidol results in increased expression of TNF protein
CTD
PMID:16478754 PMID:18554768 PMID:18590723 PMID:30217539
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnik
TRAF2 and NCK interacting kinase
decreases expression
ISO
Haloperidol results in decreased expression of TNIK mRNA
CTD
PMID:14647396
NCBI chr 2:111,184,352...111,587,993
Ensembl chr 2:111,184,387...111,580,750
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Tor1a
torsin family 1, member A
affects response to substance
ISO
TOR1A gene mutant form affects the susceptibility to Haloperidol
CTD
PMID:20227500
NCBI chr 3:14,250,667...14,257,704
Ensembl chr 3:14,250,676...14,257,691
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Tp53
tumor protein p53
increases expression
EXP
Haloperidol results in increased expression of TP53 mRNA; Haloperidol results in increased expression of TP53 protein
CTD
PMID:16462815
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Tpi1
triosephosphate isomerase 1
increases expression
EXP
Haloperidol results in increased expression of TPI1 mRNA
CTD
PMID:15860345
NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541
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Trim2
tripartite motif-containing 2
decreases expression
ISO
Haloperidol results in decreased expression of TRIM2 mRNA
CTD
PMID:14647396
NCBI chr 2:169,500,628...169,652,855
Ensembl chr 2:169,500,634...169,652,927
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Trim23
tripartite motif-containing 23
decreases expression
EXP
Haloperidol results in decreased expression of TRIM23 mRNA
CTD
PMID:15860345
NCBI chr 2:35,302,405...35,335,746
Ensembl chr 2:35,302,409...35,335,743
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Trim28
tripartite motif-containing 28
decreases expression
ISO
Haloperidol results in decreased expression of TRIM28 protein
CTD
PMID:34122009
NCBI chr 1:73,652,441...73,659,388
Ensembl chr 1:73,652,709...73,659,380
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Trmt13
tRNA methyltransferase 13 homolog
decreases expression
ISO
Haloperidol results in decreased expression of TRMT13 protein
CTD
PMID:34122009
NCBI chr 2:204,533,630...204,547,711
Ensembl chr 2:204,533,632...204,546,843
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Trpv5
transient receptor potential cation channel, subfamily V, member 5
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of TRPV5 protein
CTD
PMID:34122009
NCBI chr 4:70,536,432...70,562,743
Ensembl chr 4:70,536,440...70,562,745
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Ttbk1
tau tubulin kinase 1
increases expression
ISO
Haloperidol results in increased expression of TTBK1 protein
CTD
PMID:34122009
NCBI chr 9:14,493,166...14,538,372
Ensembl chr 9:14,493,389...14,535,774
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Tubb4b
tubulin, beta 4B class IVb
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of TUBB4B protein
CTD
PMID:34122009
NCBI chr 3:8,037,838...8,040,294
Ensembl chr 3:8,037,799...8,040,296
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Txlna
taxilin alpha
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of TXLNA protein
CTD
PMID:34122009
NCBI chr 5:141,969,337...141,985,054
Ensembl chr 5:141,969,346...141,984,583
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Uba52
ubiquitin A-52 residue ribosomal protein fusion product 1
increases expression
ISO
Haloperidol results in increased expression of UBA52 mRNA
CTD
PMID:14647396
NCBI chr16:18,918,614...18,920,807
Ensembl chr16:18,900,616...18,920,807
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Ubc
ubiquitin C
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of UBC protein
CTD
PMID:34122009
NCBI chr12:31,239,149...31,243,924
Ensembl chr12:31,239,152...31,243,925
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Ube2r2
ubiquitin-conjugating enzyme E2R 2
increases expression
ISO
Haloperidol results in increased expression of UBE2R2 mRNA
CTD
PMID:14647396
NCBI chr 5:56,286,604...56,345,160
Ensembl chr 5:56,286,725...56,345,513
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Ubqln4
ubiquilin 4
decreases expression
ISO
Haloperidol results in decreased expression of UBQLN4 protein
CTD
PMID:34122009
NCBI chr 2:174,012,726...174,028,062
Ensembl chr 2:174,012,777...174,028,059
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Ubtf
upstream binding transcription factor
decreases expression
ISO
Haloperidol results in decreased expression of UBTF protein
CTD
PMID:34122009
NCBI chr10:87,258,217...87,274,291
Ensembl chr10:87,258,217...87,272,969
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Ugp2
UDP-glucose pyrophosphorylase 2
increases expression
ISO
Haloperidol results in increased expression of UGP2 protein
CTD
PMID:34122009
NCBI chr14:95,456,330...95,497,483
Ensembl chr14:95,456,330...95,496,830
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Ugt8
UDP glycosyltransferase 8
decreases expression
ISO
Haloperidol results in decreased expression of UGT8A mRNA
CTD
PMID:17177202
NCBI chr 2:214,264,483...214,332,769
Ensembl chr 2:214,264,483...214,332,660
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Unc13a
unc-13 homolog A
decreases expression
EXP
Haloperidol results in decreased expression of UNC13A mRNA
CTD
PMID:15860345
NCBI chr16:18,333,910...18,381,813
Ensembl chr16:18,336,229...18,381,872
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Uqcr11
ubiquinol-cytochrome c reductase, complex III subunit XI
increases expression
ISO
Haloperidol results in increased expression of UQCR11 mRNA
CTD
PMID:14647396
NCBI chr 7:9,305,042...9,309,753
Ensembl chr 7:9,305,058...9,309,750
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Uso1
USO1 vesicle transport factor
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of USO1 protein
CTD
PMID:34122009
NCBI chr14:15,866,638...15,932,185
Ensembl chr14:15,866,638...15,932,171
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Usp5
ubiquitin specific peptidase 5
multiple interactions increases expression
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of USP5 protein Haloperidol results in increased expression of USP5 protein
CTD
PMID:34122009
NCBI chr 4:157,619,663...157,634,681
Ensembl chr 4:157,619,643...157,634,711
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Usp7
ubiquitin specific peptidase 7
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in increased expression of USP7 protein
CTD
PMID:34122009
NCBI chr10:6,880,684...6,925,355
Ensembl chr10:6,828,795...6,925,355
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Vamp1
vesicle-associated membrane protein 1
decreases expression increases expression
EXP
Haloperidol results in decreased expression of VAMP1 mRNA Haloperidol results in increased expression of VAMP1 mRNA
CTD
PMID:15860345
NCBI chr 4:158,012,634...158,019,350
Ensembl chr 4:158,012,663...158,019,349
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Vamp2
vesicle-associated membrane protein 2
decreases expression increases expression
EXP
Haloperidol results in decreased expression of VAMP2 mRNA Haloperidol results in increased expression of VAMP2 mRNA
CTD
PMID:15860345
NCBI chr10:53,793,581...53,797,815
Ensembl chr10:53,793,923...53,797,809
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Vipr2
vasoactive intestinal peptide receptor 2
decreases expression
ISO
Haloperidol results in decreased expression of VIPR2 mRNA
CTD
PMID:27900577
NCBI chr 6:136,996,664...137,070,599
Ensembl chr 6:137,001,511...137,070,597
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Vldlr
very low density lipoprotein receptor
increases expression
EXP
Haloperidol results in increased expression of VLDLR protein
CTD
PMID:19359144
NCBI chr 1:224,813,539...224,850,400
Ensembl chr 1:224,814,377...224,845,920
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Vsnl1
visinin-like 1
decreases expression
EXP
Haloperidol results in decreased expression of VSNL1 mRNA
CTD
PMID:12437575
NCBI chr 6:34,038,641...34,159,479
Ensembl chr 6:34,038,642...34,159,479
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Wars1
tryptophanyl-tRNA synthetase 1
multiple interactions
ISO
[Cuprizone co-treated with Haloperidol] results in decreased expression of WARS1 protein
CTD
PMID:34122009
NCBI chr 6:127,776,088...127,807,273
Ensembl chr 6:127,776,090...127,807,269
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Wbp1l
WW domain binding protein 1-like
decreases expression
ISO
Haloperidol results in decreased expression of WBP1L mRNA
CTD
PMID:14647396
NCBI chr 1:245,472,292...245,528,627
Ensembl chr 1:245,472,296...245,528,627
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Wdr12
WD repeat domain 12
decreases expression
ISO
Haloperidol results in decreased expression of WDR12 protein
CTD
PMID:34122009
NCBI chr 9:61,475,498...61,502,762
Ensembl chr 9:61,475,517...61,502,469
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Wipi1
WD repeat domain, phosphoinositide interacting 1
increases expression
ISO
Haloperidol results in increased expression of WIPI1 mRNA
CTD
PMID:17175557
NCBI chr10:94,542,946...94,580,174
Ensembl chr10:94,542,946...94,579,846
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Wwc3
WWC family member 3
decreases expression
ISO
Haloperidol results in decreased expression of WWC3 protein
CTD
PMID:34122009
NCBI chr X:23,584,204...23,701,864
Ensembl chr X:23,584,424...23,700,513
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Xirp2
xin actin-binding repeat containing 2
decreases expression
ISO
Haloperidol results in decreased expression of XIRP2 protein
CTD
PMID:34122009
NCBI chr 3:52,126,213...52,213,094
Ensembl chr 3:51,870,092...52,213,091
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Xpnpep1
X-prolyl aminopeptidase 1
increases expression
ISO
Haloperidol results in increased expression of XPNPEP1 protein
CTD
PMID:34122009
NCBI chr 1:252,001,366...252,052,077
Ensembl chr 1:252,001,367...252,051,479
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Zfr
zinc finger RNA binding protein
decreases expression
ISO
Haloperidol results in decreased expression of ZFR protein
CTD
PMID:34122009
NCBI chr 2:61,137,611...61,200,322
Ensembl chr 2:61,137,611...61,200,322
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Kcnh2
potassium voltage-gated channel subfamily H member 2
decreases activity
ISO
Mesoridazine results in decreased activity of KCNH2 protein
CTD
PMID:17042915
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
decreases methylation
ISO
CYP3A4 protein results in decreased methylation of Perazine
CTD
PMID:11026737
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Fmo3
flavin containing dimethylaniline monoxygenase 3
increases oxidation
ISO
FMO3 protein results in increased oxidation of Perazine
CTD
PMID:11026737
NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028
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Ar
androgen receptor
multiple interactions
ISO
periciazine binds to and results in decreased activity of AR protein
CTD
PMID:17606915
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Kcnh2
potassium voltage-gated channel subfamily H member 2
decreases activity
ISO
periciazine results in decreased activity of KCNH2 protein
CTD
PMID:28551711
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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Ces1d
carboxylesterase 1D
multiple interactions
ISO
Perphenazine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-nitrophenyl acetate]; Perphenazine inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]
CTD
PMID:20097249
NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions
ISO EXP
Perphenazine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
CTD
PMID:18493746
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Fshb
follicle stimulating hormone subunit beta
decreases expression
EXP
Perphenazine results in decreased expression of FSHB protein
CTD
PMID:6770916
NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
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Kcnh2
potassium voltage-gated channel subfamily H member 2
multiple interactions decreases activity
ISO
Perphenazine inhibits the reaction [KCNH2 protein results in increased transport of Thallium] Perphenazine results in decreased activity of KCNH2 protein
CTD
PMID:21158687 PMID:28551711
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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Lhb
luteinizing hormone subunit beta
decreases expression
EXP
Perphenazine results in decreased expression of LHB protein
CTD
PMID:6770916
NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
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Prl
prolactin
increases expression
ISO EXP
Perphenazine results in increased expression of PRL protein
CTD
PMID:6770916 PMID:7262630 PMID:17335319
NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Perphenazine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Tnni3
troponin I3, cardiac type
increases expression
ISO
Perphenazine results in increased expression of TNNI3 protein
CTD
PMID:14742781
NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580
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Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
Pimozide results in decreased expression of BCL2 mRNA
CTD
PMID:12130671
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions increases expression
EXP
istradefylline inhibits the reaction [Pimozide results in increased expression of FOS protein]; Tropicamide promotes the reaction [Pimozide results in increased expression of FOS protein]
CTD
PMID:19467297
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Kcna10
potassium voltage-gated channel subfamily A member 10
multiple interactions
ISO
Pimozide inhibits the reaction [KCNA10 protein results in increased transport of Potassium]
CTD
PMID:10836990
NCBI chr 2:194,786,500...194,798,575
Ensembl chr 2:194,786,500...194,798,575
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Kcnh2
potassium voltage-gated channel subfamily H member 2
multiple interactions decreases activity
ISO
Pimozide inhibits the reaction [KCNH2 protein results in increased transport of Thallium] Pimozide results in decreased activity of KCNH2 protein
CTD
PMID:15671647 PMID:19583963 PMID:21158687 PMID:24052561
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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Lhb
luteinizing hormone subunit beta
multiple interactions
EXP
Pimozide results in decreased secretion of and results in decreased glycosylation of LHB protein
CTD
PMID:3896764
NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
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Prl
prolactin
increases expression
ISO
Pimozide results in increased expression of PRL protein
CTD
PMID:8915564
NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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Ache
acetylcholinesterase
increases activity
ISO
Prochlorperazine results in increased activity of ACHE protein
CTD
PMID:29614332
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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Esr1
estrogen receptor 1
multiple interactions
ISO
Prochlorperazine binds to and results in increased activity of ESR1 protein
CTD
PMID:25752796
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Tfeb
transcription factor EB
affects localization
ISO
Prochlorperazine affects the localization of TFEB protein
CTD
PMID:28366621
NCBI chr 9:13,198,890...13,254,726
Ensembl chr 9:13,198,891...13,254,714
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Bche
butyrylcholinesterase
decreases activity
ISO
Promazine results in decreased activity of BCHE protein
CTD
PMID:236606
NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
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Crh
corticotropin releasing hormone
decreases expression
ISO
Promazine results in decreased expression of CRH mRNA
CTD
PMID:16205782
NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
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Kcnh2
potassium voltage-gated channel subfamily H member 2
decreases activity
ISO
Promazine results in decreased activity of KCNH2 protein
CTD
PMID:28551711
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Promazine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Abcb11
ATP binding cassette subfamily B member 11
multiple interactions decreases activity
ISO
Reserpine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid] Reserpine results in decreased activity of ABCB11 protein
CTD
PMID:20829430 PMID:23956101 PMID:24014644
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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Abcb1a
ATP binding cassette subfamily B member 1A
multiple interactions increases expression decreases activity
ISO
Cycloheximide promotes the reaction [Reserpine results in increased expression of ABCB1 mRNA]; Reserpine inhibits the reaction [ABCB1 protein affects the export of calcein AM]; Reserpine inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Reserpine inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine] Reserpine inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon] Reserpine results in increased expression of ABCB1 mRNA; Reserpine results in increased expression of ABCB1 protein Reserpine results in decreased activity of ABCB1 protein
CTD
PMID:7476894 PMID:8632764 PMID:10617675 PMID:12235267 PMID:19528478
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Abcg2
ATP binding cassette subfamily G member 2
multiple interactions
ISO
Reserpine inhibits the reaction [ABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; Reserpine inhibits the reaction [ABCG2 protein results in increased transport of Irinotecan]
CTD
PMID:12869632
NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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Ache
acetylcholinesterase
multiple interactions affects activity
EXP
[Plant Extracts results in increased abundance of Dronabinol] inhibits the reaction [Reserpine affects the activity of ACHE protein]
CTD
PMID:28212939
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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Adra1d
adrenoceptor alpha 1D
increases response to substance increases expression
EXP
ADRA1D protein results in increased susceptibility to Reserpine Reserpine results in increased expression of ADRA1D mRNA
CTD
PMID:15159276 PMID:17676312
NCBI chr 3:118,793,356...118,809,354
Ensembl chr 3:118,793,346...118,809,354
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Adra2a
adrenoceptor alpha 2A
increases expression
EXP
Reserpine results in increased expression of ADRA2A mRNA
CTD
PMID:11264240
NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365
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Adrb1
adrenoceptor beta 1
increases expression increases stability
EXP
Reserpine results in increased expression of ADRB1 mRNA; Reserpine results in increased expression of ADRB1 protein Reserpine results in increased stability of ADRB1 mRNA
CTD
PMID:1336118
NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259
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Adrb2
adrenoceptor beta 2
increases expression
EXP
Reserpine results in increased expression of ADRB2 mRNA
CTD
PMID:1664493
NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
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Agtr2
angiotensin II receptor, type 2
increases expression
EXP
Reserpine results in increased expression of AGTR2 mRNA; Reserpine results in increased expression of AGTR2 protein
CTD
PMID:20964730
NCBI chr X:112,119,876...112,124,060
Ensembl chr X:112,120,228...112,124,057
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Akr1b10
aldo-keto reductase family 1 member B10
increases expression
ISO
Reserpine results in increased expression of AKR1B10 mRNA
CTD
PMID:26198647
NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
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Akt1
AKT serine/threonine kinase 1
decreases phosphorylation multiple interactions
ISO
Reserpine results in decreased phosphorylation of AKT1 protein arsenic trioxide promotes the reaction [Reserpine results in decreased phosphorylation of AKT1 protein]
CTD
PMID:26114099
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Amd1
adenosylmethionine decarboxylase 1
multiple interactions
ISO
Reserpine inhibits the reaction [Folic Acid results in increased activity of AMD1 protein]
CTD
PMID:17371283
NCBI chr20:43,695,783...43,711,476
Ensembl chr20:43,697,237...43,711,476
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Ar
androgen receptor
multiple interactions
ISO
Reserpine inhibits the reaction [Stanozolol binds to and results in increased activity of AR protein]
CTD
PMID:29162470
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Arc
activity-regulated cytoskeleton-associated protein
multiple interactions
EXP
Reserpine inhibits the reaction [Cocaine results in increased expression of ARC mRNA]
CTD
PMID:7722525
NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions increases expression
EXP
IAPP protein inhibits the reaction [Reserpine results in increased expression of BAX protein]
CTD
PMID:19463876
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
multiple interactions decreases expression
EXP
IAPP protein inhibits the reaction [Reserpine results in decreased expression of BCL2 protein]
CTD
PMID:19463876
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bdnf
brain-derived neurotrophic factor
decreases expression multiple interactions
ISO EXP
Reserpine results in decreased expression of BDNF protein cerebrolysin inhibits the reaction [Reserpine results in decreased expression of BDNF protein]; Fluoxetine inhibits the reaction [Reserpine results in decreased expression of BDNF protein] arsenic trioxide promotes the reaction [Reserpine results in decreased expression of BDNF protein]
CTD
PMID:26114099 PMID:33279466
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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Birc5
baculoviral IAP repeat-containing 5
affects binding
ISO
Reserpine binds to BIRC5 promoter
CTD
PMID:17968851
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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C3
complement C3
affects expression
EXP
Reserpine affects the expression of C3 mRNA
CTD
PMID:18363858
NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
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Casp3
caspase 3
multiple interactions increases activity
EXP
IAPP protein inhibits the reaction [Reserpine results in increased activity of CASP3 protein]
CTD
PMID:19463876
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp8
caspase 8
multiple interactions increases activity
EXP
IAPP protein inhibits the reaction [Reserpine results in increased activity of CASP8 protein]
CTD
PMID:19463876
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Cat
catalase
multiple interactions decreases expression increases expression
EXP
Plant Extracts inhibits the reaction [Reserpine results in decreased expression of CAT protein]; Quercetin inhibits the reaction [Reserpine results in decreased expression of CAT protein] Reserpine results in increased expression of CAT protein
CTD
PMID:14685008 PMID:16444668 PMID:19109989 PMID:19761039 PMID:20628966
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ccnd1
cyclin D1
decreases expression
ISO
Reserpine results in decreased expression of CCND1 mRNA; Reserpine results in decreased expression of CCND1 protein
CTD
PMID:19607803
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
G
Cdkn1b
cyclin-dependent kinase inhibitor 1B
multiple interactions
EXP
[troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of CDKN1B protein
CTD
PMID:11318962
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
G
Cdkn2a
cyclin-dependent kinase inhibitor 2A
multiple interactions
EXP
[Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine] inhibits the reaction [Desoxycorticosterone Acetate affects the localization of CDKN2A protein]; [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine] inhibits the reaction [Desoxycorticosterone Acetate results in increased expression of CDKN2A mRNA]
CTD
PMID:18504326
NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
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Chga
chromogranin A
multiple interactions increases expression increases activity
ISO EXP
CHGA protein alternative form inhibits the reaction [Reserpine results in increased activity of CHGA promoter]; Chlorisondamine inhibits the reaction [Reserpine results in increased activity of CHGA promoter] Reserpine results in increased expression of CHGA mRNA
CTD
PMID:1907749 PMID:8189248 PMID:12799369
NCBI chr 6:121,696,051...121,707,399
Ensembl chr 6:121,696,051...121,707,398
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Chgb
chromogranin B
increases expression
EXP
Reserpine results in increased expression of CHGB mRNA; Reserpine results in increased expression of CHGB protein
CTD
PMID:1907749 PMID:8189248 PMID:8361347
NCBI chr 3:120,043,824...120,057,169
Ensembl chr 3:120,043,738...120,057,166
G
Chrm1
cholinergic receptor, muscarinic 1
increases expression decreases expression
EXP
Reserpine results in increased expression of CHRM1 mRNA Reserpine results in decreased expression of CHRM1 protein
CTD
PMID:1506860
NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356
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Cnr1
cannabinoid receptor 1
decreases expression
EXP
Reserpine results in decreased expression of CNR1 mRNA
CTD
PMID:11358453
NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
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Cpe
carboxypeptidase E
increases expression
EXP
Reserpine results in increased expression of CPE mRNA
CTD
PMID:8189248
NCBI chr16:25,030,276...25,142,231
Ensembl chr16:25,030,276...25,142,233
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Crem
cAMP responsive element modulator
multiple interactions increases expression
EXP
Reserpine promotes the reaction [CREM protein binds to TH promoter] Reserpine results in increased expression of CREM mRNA alternative form; Reserpine results in increased expression of CREM protein; Reserpine results in increased expression of CREM protein alternative form
CTD
PMID:8810303 PMID:11438978
NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989
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Crh
corticotropin releasing hormone
increases expression
EXP
Reserpine results in increased expression of CRH mRNA; Reserpine results in increased expression of CRH protein
CTD
PMID:1850078
NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions
ISO
Reserpine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Reserpine promotes the reaction [Benzo(a)pyrene results in increased expression of and results in increased activity of CYP1A1 protein]; Reserpine promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]
CTD
PMID:15627480 PMID:18493746
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
multiple interactions
EXP
[Reserpine results in decreased abundance of Catecholamines] promotes the reaction [Benzo(a)pyrene results in increased expression of and results in increased activity of CYP1A2 protein]; [Reserpine results in decreased abundance of Catecholamines] promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]; Reserpine promotes the reaction [Benzo(a)pyrene results in increased expression of and results in increased activity of CYP1A2 protein]; Reserpine promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]
CTD
PMID:16510159
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
multiple interactions
ISO
[Reserpine results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA
CTD
PMID:17041008
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases expression multiple interactions
ISO
Reserpine results in increased expression of CYP3A4 mRNA; Reserpine results in increased expression of CYP3A4 protein [Reserpine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; Reserpine inhibits the reaction [Calcitriol results in increased expression of CYP3A4 protein]
CTD
PMID:8632764 PMID:16837568 PMID:17041008 PMID:29782822
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Cyp3a9
cytochrome P450, family 3, subfamily a, polypeptide 9
increases expression
ISO
Reserpine results in increased expression of CYP3A5 protein
CTD
PMID:8632764
NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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Cyss
cystatin S
multiple interactions
EXP
Reserpine inhibits the reaction [Isoproterenol results in increased expression of CYSS mRNA]
CTD
PMID:9447264
NCBI chr 3:137,432,049...137,436,654
Ensembl chr 3:137,432,049...137,436,610
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Dbh
dopamine beta-hydroxylase
decreases activity increases expression increases stability increases activity
EXP
Reserpine results in decreased activity of DBH protein Reserpine results in increased expression of DBH mRNA Reserpine results in increased stability of DBH protein Reserpine results in increased activity of DBH protein
CTD
PMID:1359376 PMID:2325165 PMID:7984052 PMID:8189248
NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248
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Ddc
dopa decarboxylase
increases expression
EXP
Reserpine results in increased expression of DDC mRNA
CTD
PMID:1359376
NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208
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Drd1
dopamine receptor D1
increases expression
EXP
Reserpine results in increased expression of DRD1 mRNA
CTD
PMID:8419537
NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
G
Drd2
dopamine receptor D2
multiple interactions increases expression
ISO EXP
DRD2 protein affects the susceptibility to [8-(3-chlorostyryl)caffeine co-treated with Reserpine] Reserpine results in increased expression of DRD2 mRNA; Reserpine results in increased expression of DRD2 mRNA alternative form
CTD
PMID:1331675 PMID:8419537 PMID:11172060
NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
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Egr1
early growth response 1
multiple interactions increases expression
EXP
[Reserpine co-treated with Levodopa] results in increased expression of EGR1 mRNA; eticlopride inhibits the reaction [[Reserpine co-treated with Levodopa] results in increased expression of EGR1 mRNA]; Quinpirole inhibits the reaction [Reserpine results in increased expression of EGR1 mRNA]; Reserpine promotes the reaction [Dextroamphetamine results in increased expression of EGR1 mRNA]; SCH 23390 inhibits the reaction [[Reserpine co-treated with Levodopa] results in increased expression of EGR1 mRNA]; SCH 23390 inhibits the reaction [Reserpine promotes the reaction [Dextroamphetamine results in increased expression of EGR1 mRNA]] Reserpine results in increased expression of EGR1 mRNA; Reserpine results in increased expression of EGR1 protein
CTD
PMID:1347779 PMID:8063705 PMID:9729266 PMID:9890435
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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Erbb2
erb-b2 receptor tyrosine kinase 2
increases response to substance
EXP
ERBB2 protein results in increased susceptibility to Reserpine
CTD
PMID:8093862
NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
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Fabp7
fatty acid binding protein 7
affects expression
EXP
Reserpine affects the expression of FABP7 mRNA
CTD
PMID:18363858
NCBI chr20:37,123,193...37,126,725
Ensembl chr20:37,123,193...37,126,880
G
Fos
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions increases expression increases phosphorylation
EXP
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine promotes the reaction [Reserpine results in increased expression of FOS protein]; 3,7-dimethyl-1-propargylxanthine inhibits the reaction [Reserpine results in increased expression of FOS protein]; 8-(3-chlorostyryl)caffeine promotes the reaction [Quinpirole inhibits the reaction [Reserpine results in increased expression of FOS protein]]; Quinpirole inhibits the reaction [Reserpine results in increased expression of FOS protein]; Quinpirole promotes the reaction [Reserpine results in increased expression of FOS protein]; Reserpine inhibits the reaction [[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Quinpirole] results in increased expression of FOS protein]; Reserpine inhibits the reaction [Cocaine results in increased expression of FOS protein]; Reserpine promotes the reaction [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of FOS protein]; Reserpine promotes the reaction [Amphetamine results in increased expression of FOS protein]; Reserpine promotes the reaction [Quinpirole results in increased expression of FOS protein]; Theophylline inhibits the reaction [Reserpine results in increased expression of FOS protein] Reserpine results in increased expression of FOS mRNA; Reserpine results in increased expression of FOS protein Reserpine results in increased phosphorylation of FOS protein
CTD
PMID:1359376 PMID:1686849 PMID:2118661 PMID:7845612 PMID:7914358 PMID:8100600 PMID:8102797 PMID:8577368 PMID:8864302 PMID:9210518 More...
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Gad1
glutamate decarboxylase 1
increases expression multiple interactions
EXP
Reserpine results in increased expression of GAD1 mRNA Clenbuterol inhibits the reaction [Reserpine results in increased expression of GAD1 mRNA]
CTD
PMID:8774452
NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
G
Gal
galanin and GMAP prepropeptide
decreases expression increases expression multiple interactions
EXP
Reserpine results in decreased expression of GAL mRNA Reserpine results in increased expression of GAL mRNA Desipramine inhibits the reaction [Reserpine results in increased expression of GAL mRNA]
CTD
PMID:1279347 PMID:1698642 PMID:1705056 PMID:1717808 PMID:9512271 PMID:19598284 More...
NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959
G
Gast
gastrin
multiple interactions
EXP
Reserpine inhibits the reaction [Levodopa results in decreased cleavage of GAST protein]
CTD
PMID:10332097
NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496
G
Gch1
GTP cyclohydrolase 1
increases expression
EXP
Reserpine results in increased expression of GCH1 mRNA; Reserpine results in increased expression of GCH1 mRNA alternative form
CTD
PMID:8103077
NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698
G
Gcnt3
glucosaminyl (N-acetyl) transferase 3, mucin type
increases expression
ISO
Reserpine results in increased expression of GCNT3 mRNA
CTD
PMID:26198647
NCBI chr 8:70,689,173...70,696,476
Ensembl chr 8:70,686,844...70,699,562
G
Gnai1
G protein subunit alpha i1
increases expression
EXP
Reserpine results in increased expression of GNAI1 protein
CTD
PMID:11264240
NCBI chr 4:16,814,000...16,898,119
Ensembl chr 4:16,814,001...16,896,417
G
Gnai2
G protein subunit alpha i2
increases expression
EXP
Reserpine results in increased expression of GNAI2 mRNA; Reserpine results in increased expression of GNAI2 protein
CTD
PMID:8419537 PMID:11264240
NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979
G
Gnai3
G protein subunit alpha i3
increases expression
EXP
Reserpine results in increased expression of GNAI3 protein
CTD
PMID:11264240
NCBI chr 2:195,742,765...195,780,720
Ensembl chr 2:195,742,642...195,780,742
G
Gnao1
G protein subunit alpha o1
increases expression
EXP
Reserpine results in increased expression of GNAO1 mRNA; Reserpine results in increased expression of GNAO1 protein
CTD
PMID:8419537 PMID:11264240
NCBI chr19:11,034,874...11,192,531
Ensembl chr19:11,035,956...11,192,493
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Gnas
GNAS complex locus
increases expression decreases expression
EXP
Reserpine results in increased expression of GNAS mRNA; Reserpine results in increased expression of GNAS protein Reserpine results in decreased expression of GNAS protein alternative form
CTD
PMID:1336118 PMID:8419537 PMID:11264240
NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262 Ensembl chr 3:163,071,417...163,127,262
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Grm5
glutamate metabotropic receptor 5
decreases expression increases expression
EXP
Reserpine results in decreased expression of GRM5 mRNA Reserpine results in increased expression of GRM5 protein
CTD
PMID:16890937
NCBI chr 1:141,310,069...141,884,980
Ensembl chr 1:141,312,368...141,882,274
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Hgf
hepatocyte growth factor
increases expression
EXP
Reserpine results in increased expression of HGF protein
CTD
PMID:16081063
NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
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Hspg2
heparan sulfate proteoglycan 2
multiple interactions
ISO
HSPG2 gene results in increased susceptibility to [Haloperidol co-treated with Reserpine]
CTD
PMID:20072119
NCBI chr 5:149,677,437...149,778,594
Ensembl chr 5:149,677,476...149,778,594
G
Htr1a
5-hydroxytryptamine receptor 1A
decreases expression
ISO
Reserpine results in decreased expression of HTR1A protein
CTD
PMID:26114099
NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442
G
Iapp
islet amyloid polypeptide
multiple interactions
EXP
IAPP protein inhibits the reaction [Reserpine results in decreased expression of BCL2 protein]; IAPP protein inhibits the reaction [Reserpine results in increased activity of CASP3 protein]; IAPP protein inhibits the reaction [Reserpine results in increased activity of CASP8 protein]; IAPP protein inhibits the reaction [Reserpine results in increased expression of BAX protein]; IAPP protein inhibits the reaction [Reserpine results in increased expression of TNFSF10 protein]
CTD
PMID:19463876
NCBI chr 4:175,237,107...175,244,373
Ensembl chr 4:175,237,115...175,242,920
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Il10
interleukin 10
decreases expression multiple interactions
ISO
Reserpine results in decreased expression of IL10 mRNA; Reserpine results in decreased expression of IL10 protein SCH 23390 inhibits the reaction [Reserpine results in decreased expression of IL10 mRNA]; SCH 23390 inhibits the reaction [Reserpine results in decreased expression of IL10 protein]
CTD
PMID:16985181
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il18
interleukin 18
increases expression
EXP
Reserpine results in increased expression of IL18 mRNA
CTD
PMID:8999896
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
G
Jun
Jun proto-oncogene, AP-1 transcription factor subunit
increases expression
EXP
Reserpine results in increased expression of JUN mRNA
CTD
PMID:1359376
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
G
Junb
JunB proto-oncogene, AP-1 transcription factor subunit
multiple interactions
EXP
Reserpine promotes the reaction [Dextroamphetamine results in increased expression of JUNB mRNA]; SCH 23390 inhibits the reaction [Reserpine promotes the reaction [Dextroamphetamine results in increased expression of JUNB mRNA]]
CTD
PMID:1347779
NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
G
Kcna3
potassium voltage-gated channel subfamily A member 3
decreases activity multiple interactions
ISO
Reserpine results in decreased activity of KCNA3 protein [Reserpine results in decreased activity of KCNA3 protein] which results in decreased import of Thallium
CTD
PMID:21362439
NCBI chr 2:194,632,106...194,634,059
Ensembl chr 2:194,632,196...194,650,138
G
Kcna5
potassium voltage-gated channel subfamily A member 5
increases expression
EXP
Reserpine results in increased expression of KCNA5 mRNA
CTD
PMID:12606256
NCBI chr 4:159,354,689...159,358,173
Ensembl chr 4:159,350,097...159,357,697
G
Kcnd2
potassium voltage-gated channel subfamily D member 2
decreases expression
EXP
Reserpine results in decreased expression of KCND2 mRNA
CTD
PMID:12606256
NCBI chr 4:49,775,812...50,277,746
Ensembl chr 4:49,776,246...50,277,728
G
Kcnd3
potassium voltage-gated channel subfamily D member 3
decreases expression
EXP
Reserpine results in decreased expression of KCND3 mRNA
CTD
PMID:12606256
NCBI chr 2:192,937,950...193,155,345
Ensembl chr 2:192,937,950...193,155,345
G
Kcnh2
potassium voltage-gated channel subfamily H member 2
decreases activity multiple interactions
ISO
Reserpine results in decreased activity of KCNH2 protein [Reserpine results in decreased activity of KCNH2 protein] which results in decreased import of Thallium
CTD
PMID:21362439 PMID:28551711
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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Lep
leptin
increases expression
ISO
Reserpine results in increased expression of LEP mRNA
CTD
PMID:10050748
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
G
Myc
MYC proto-oncogene, bHLH transcription factor
increases response to substance decreases expression
ISO
MYC protein results in increased susceptibility to Reserpine Reserpine results in decreased expression of MYC protein
CTD
PMID:8093862 PMID:19607803
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
G
Ncf1
neutrophil cytosolic factor 1
increases expression
EXP
Reserpine results in increased expression of NCF1 mRNA; Reserpine results in increased expression of NCF1 protein
CTD
PMID:20964730
NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
G
Nfe2l2
NFE2 like bZIP transcription factor 2
decreases activity
ISO
Reserpine results in decreased activity of NFE2L2 protein
CTD
PMID:30203046
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
G
Ngf
nerve growth factor
increases expression
EXP
Reserpine results in increased expression of NGF mRNA; Reserpine results in increased expression of NGF protein
CTD
PMID:1996081 PMID:8593794
NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
G
Nos1
nitric oxide synthase 1
increases expression
EXP
Reserpine results in increased expression of NOS1 mRNA; Reserpine results in increased expression of NOS1 protein
CTD
PMID:7533141
NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
G
Npy
neuropeptide Y
multiple interactions increases expression decreases expression
EXP
Chlorisondamine inhibits the reaction [Reserpine results in increased expression of NPY mRNA]; Chlorisondamine promotes the reaction [Reserpine results in increased expression of NPY mRNA]; Dexamethasone inhibits the reaction [Reserpine results in increased expression of NPY mRNA] Reserpine results in increased expression of NPY mRNA; Reserpine results in increased expression of NPY protein Reserpine results in decreased expression of NPY mRNA; Reserpine results in decreased expression of NPY protein
CTD
PMID:1671012 PMID:1676830 PMID:1687976 PMID:1698642 PMID:1713314 PMID:1714554 PMID:1878751 PMID:1907749 PMID:2233698 PMID:2897091 PMID:2903502 PMID:3215285 PMID:3805164 PMID:7644023 PMID:7911764 PMID:8189248 PMID:20504635 More...
NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
G
Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions
ISO
[Reserpine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CTD
PMID:17041008
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Nr1i3
nuclear receptor subfamily 1, group I, member 3
multiple interactions decreases activity
ISO
[Reserpine results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA Reserpine results in decreased activity of NR1I3 protein
CTD
PMID:17041008 PMID:30203046
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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Nr3c1
nuclear receptor subfamily 3, group C, member 1
increases expression
EXP
Reserpine results in increased expression of NR3C1 mRNA
CTD
PMID:7984052
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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Ntrk2
neurotrophic receptor tyrosine kinase 2
multiple interactions decreases expression
ISO
arsenic trioxide promotes the reaction [Reserpine results in decreased expression of NTRK2 protein]
CTD
PMID:26114099
NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
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Nts
neurotensin
increases expression
EXP
Reserpine results in increased expression of NTS mRNA
CTD
PMID:1850078
NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423
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Odc1
ornithine decarboxylase 1
decreases expression multiple interactions
EXP ISO
Reserpine results in decreased expression of ODC1 protein Reserpine inhibits the reaction [CB 3717 results in increased activity of ODC1 protein]; Reserpine inhibits the reaction [CB 3717 results in increased expression of ODC1 mRNA]; Reserpine inhibits the reaction [Testosterone results in increased activity of ODC1 protein]; Reserpine inhibits the reaction [Testosterone results in increased expression of ODC1 mRNA]
CTD
PMID:6519379 PMID:9194572 PMID:10354516 PMID:17371283
NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
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Pam
peptidylglycine alpha-amidating monooxygenase
increases expression
EXP
Reserpine results in increased expression of PAM mRNA
CTD
PMID:8189248
NCBI chr 9:97,998,581...98,271,966
Ensembl chr 9:98,122,916...98,271,965
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Pcna
proliferating cell nuclear antigen
multiple interactions
EXP
[troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of PCNA protein
CTD
PMID:11318962
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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Pcsk2
proprotein convertase subtilisin/kexin type 2
increases expression
EXP
Reserpine results in increased expression of PCSK2 mRNA
CTD
PMID:8189248
NCBI chr 3:130,880,422...131,183,127
Ensembl chr 3:130,880,422...131,183,127
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Penk
proenkephalin
multiple interactions increases expression decreases expression
EXP
Apomorphine inhibits the reaction [Reserpine results in increased expression of PENK mRNA] Reserpine results in increased expression of PENK mRNA; Reserpine results in increased expression of PENK protein Reserpine results in decreased expression of PENK mRNA
CTD
PMID:1331675 PMID:1850078 PMID:3188958 PMID:3838946 PMID:4078631 PMID:7494455 PMID:17719177 More...
NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129
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Pnmt
phenylethanolamine-N-methyltransferase
multiple interactions increases expression decreases expression
EXP
Chlorisondamine inhibits the reaction [Reserpine results in decreased expression of PNMT mRNA]; Dexamethasone inhibits the reaction [Reserpine results in decreased expression of PNMT mRNA]; POMC protein alternative form inhibits the reaction [Reserpine results in decreased expression of PNMT mRNA]; Reserpine results in increased expression of and results in increased activity of PNMT protein Reserpine results in increased expression of PNMT mRNA
CTD
PMID:1359376 PMID:1687976 PMID:1714554 PMID:2903502 PMID:8063705 PMID:8479280 PMID:20504635 More...
NCBI chr10:83,383,019...83,386,557
Ensembl chr10:83,384,923...83,386,556
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Pomc
proopiomelanocortin
increases expression multiple interactions
EXP
Reserpine results in increased expression of POMC mRNA; Reserpine results in increased expression of POMC protein alternative form POMC protein alternative form inhibits the reaction [Reserpine results in decreased expression of PNMT mRNA]
CTD
PMID:8479280 PMID:20504635
NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
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Prkaca
protein kinase cAMP-activated catalytic subunit alpha
decreases expression
ISO
Reserpine results in decreased expression of PRKACA protein
CTD
PMID:26114099
NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430
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Prl
prolactin
increases expression
EXP
Reserpine results in increased expression of PRL protein
CTD
PMID:11071396
NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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Prss1
serine protease 1
decreases expression increases expression
EXP
Reserpine results in decreased expression of PRSS1 protein Reserpine results in increased expression of PRSS1 protein
CTD
PMID:8625754
NCBI chr 4:70,364,589...70,367,792
Ensembl chr 4:70,364,586...70,367,792
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Ptgs2
prostaglandin-endoperoxide synthase 2
increases expression
EXP
Reserpine results in increased expression of PTGS2 protein
CTD
PMID:16081063
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Pts
6-pyruvoyl-tetrahydropterin synthase
increases expression
EXP
Reserpine results in increased expression of PTS mRNA
CTD
PMID:7545485
NCBI chr 8:50,870,838...50,877,869
Ensembl chr 8:50,870,841...50,877,869
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Rasd2
RASD family, member 2
decreases expression
EXP
Reserpine results in decreased expression of RASD2 mRNA
CTD
PMID:16352400
NCBI chr19:13,594,291...13,605,016
Ensembl chr19:13,594,291...13,605,016
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Rgs10
regulator of G-protein signaling 10
decreases expression
EXP
Reserpine results in decreased expression of RGS10 mRNA
CTD
PMID:14505795
NCBI chr 1:182,946,334...182,987,729
Ensembl chr 1:182,946,336...182,987,697
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Rgs2
regulator of G-protein signaling 2
decreases expression
EXP
Reserpine results in decreased expression of RGS2 mRNA
CTD
PMID:14505795
NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385
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Rgs4
regulator of G-protein signaling 4
decreases expression
EXP
Reserpine results in decreased expression of RGS4 mRNA
CTD
PMID:14505795
NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068
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Rgs5
regulator of G-protein signaling 5
decreases expression
EXP
Reserpine results in decreased expression of RGS5 mRNA
CTD
PMID:14505795
NCBI chr13:81,848,254...81,885,053
Ensembl chr13:81,836,304...81,885,518
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Rgs8
regulator of G-protein signaling 8
decreases expression
EXP
Reserpine results in decreased expression of RGS8 mRNA
CTD
PMID:14505795
NCBI chr13:65,804,703...65,848,955
Ensembl chr13:65,804,797...65,846,807
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Rgs9
regulator of G-protein signaling 9
affects response to substance decreases expression
ISO EXP
RGS9 affects the susceptibility to Reserpine Reserpine results in decreased expression of RGS9 mRNA
CTD
PMID:14505795 PMID:15728856
NCBI chr10:94,195,265...94,270,892
Ensembl chr10:94,197,054...94,270,892
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Scg2
secretogranin II
increases expression
EXP
Reserpine results in increased expression of SCG2 mRNA
CTD
PMID:1907749 PMID:8189248 PMID:8361347
NCBI chr 9:80,803,074...80,808,646
Ensembl chr 9:80,803,075...80,821,097
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Serpine1
serpin family E member 1
multiple interactions
EXP
[troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of SERPINE1 mRNA; [troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of SERPINE1 protein
CTD
PMID:11318962
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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Siah1
siah E3 ubiquitin protein ligase 1
increases expression
ISO
Reserpine results in increased expression of SIAH1 mRNA
CTD
PMID:19607803
NCBI chr19:20,378,908...20,402,512
Ensembl chr19:20,378,439...20,403,808
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Slc18a1
solute carrier family 18 member A1
decreases activity multiple interactions
ISO
Reserpine results in decreased activity of SLC18A1 protein Reserpine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin]
CTD
PMID:8245983 PMID:21712771
NCBI chr16:20,653,268...20,687,051
Ensembl chr16:20,653,508...20,687,051
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Slc18a2
solute carrier family 18 member A2
affects binding multiple interactions decreases activity increases expression affects response to substance decreases response to substance
ISO EXP
Reserpine binds to SLC18A2 protein Reserpine inhibits the reaction [SLC18A2 protein results in increased uptake of Dopamine] Reserpine results in decreased activity of SLC18A2 protein SLC18A2 protein binds to Reserpine Reserpine results in increased expression of SLC18A2 mRNA SLC18A2 affects the susceptibility to Reserpine Reserpine inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; Serotonin inhibits the reaction [SLC18A2 protein binds to Reserpine] SLC18A2 gene SNP results in decreased susceptibility to Reserpine
CTD
PMID:1438304 PMID:7912402 PMID:8189248 PMID:9038139 PMID:15475732 PMID:17664021 PMID:18287335 PMID:29908239 PMID:33378168 More...
NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325
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Slc6a2
solute carrier family 6 member 2
decreases expression
EXP
Reserpine results in decreased expression of SLC6A2 mRNA
CTD
PMID:7478180 PMID:7616203
NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357
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Slc6a3
solute carrier family 6 member 3
decreases activity affects response to substance
ISO
Reserpine results in decreased activity of SLC6A3 protein SLC6A3 gene mutant form affects the susceptibility to Reserpine
CTD
PMID:17664021 PMID:19615345
NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
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Slc6a4
solute carrier family 6 member 4
decreases expression
EXP
Reserpine results in decreased expression of SLC6A4 mRNA
CTD
PMID:10027743
NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
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Snca
synuclein alpha
affects response to substance
ISO
SNCA protein mutant form affects the susceptibility to Reserpine
CTD
PMID:18622040
NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
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Sqstm1
sequestosome 1
increases expression
ISO
Reserpine results in increased expression of SQSTM1 mRNA
CTD
PMID:26198647
NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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Syt7
synaptotagmin 7
multiple interactions
EXP
[Reserpine co-treated with Apomorphine] results in increased expression of SYT7 mRNA
CTD
PMID:17719177
NCBI chr 1:207,031,359...207,093,787
Ensembl chr 1:207,031,592...207,089,026
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Tac1
tachykinin, precursor 1
multiple interactions increases expression
EXP
[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Reserpine co-treated with Quinpirole] results in increased expression of TAC1 mRNA; [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Reserpine] results in increased expression of TAC1 mRNA; Apomorphine promotes the reaction [Reserpine results in increased expression of TAC1 mRNA]
CTD
PMID:9751140 PMID:17719177
NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
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Tff1
trefoil factor 1
increases expression
ISO
Reserpine results in increased expression of TFF1 mRNA
CTD
PMID:35307500
NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
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Th
tyrosine hydroxylase
increases expression increases activity decreases expression affects activity increases stability multiple interactions
ISO EXP
Reserpine results in increased expression of TH mRNA Reserpine results in increased activity of TH protein Reserpine results in increased expression of TH mRNA; Reserpine results in increased expression of TH protein Reserpine results in decreased expression of TH mRNA Reserpine affects the activity of TH protein Reserpine results in increased stability of TH mRNA Bicuculline promotes the reaction [Reserpine affects the activity of TH protein]; Bicuculline promotes the reaction [Reserpine results in increased expression of TH mRNA]; Chlorisondamine inhibits the reaction [Reserpine results in increased expression of TH mRNA]; Chlorisondamine promotes the reaction [Reserpine results in increased expression of TH mRNA]; Desipramine inhibits the reaction [Reserpine results in increased expression of TH mRNA]; Reserpine promotes the reaction [CREM protein binds to TH promoter]; Reserpine results in increased expression of and results in increased activity of TH protein
CTD
PMID:1350653 PMID:1359376 PMID:1676830 PMID:1687822 PMID:1687976 PMID:1698642 PMID:1705056 PMID:1714554 PMID:1717808 PMID:1970845 PMID:1976760 PMID:1978789 PMID:1981253 PMID:2568627 PMID:2862954 PMID:2863328 PMID:2872048 PMID:2881815 PMID:2882513 PMID:2883324 PMID:2903502 PMID:7478180 PMID:7532593 PMID:7545485 PMID:7616203 PMID:7911764 PMID:8369965 PMID:8666980 PMID:9210518 PMID:9691425 PMID:11161478 PMID:11438978 PMID:20504635 More...
NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
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Tnf
tumor necrosis factor
increases expression multiple interactions
EXP
Reserpine results in increased expression of TNF protein cerebrolysin inhibits the reaction [Reserpine results in increased expression of TNF protein]; Fluoxetine inhibits the reaction [Reserpine results in increased expression of TNF protein]
CTD
PMID:33279466
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnfsf10
TNF superfamily member 10
multiple interactions increases expression
EXP
IAPP protein inhibits the reaction [Reserpine results in increased expression of TNFSF10 protein]
CTD
PMID:19463876
NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
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Tph1
tryptophan hydroxylase 1
increases activity decreases activity
EXP
Reserpine results in increased activity of TPH1 protein Reserpine results in decreased activity of TPH1 protein
CTD
PMID:8369965
NCBI chr 1:97,157,375...97,178,415
Ensembl chr 1:97,157,409...97,178,344
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Vgf
VGF nerve growth factor inducible
increases expression
EXP
Reserpine results in increased expression of VGF mRNA
CTD
PMID:8189248
NCBI chr12:19,637,313...19,645,123
Ensembl chr12:19,637,320...19,640,341
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Vip
vasoactive intestinal peptide
increases expression
EXP
Reserpine results in increased expression of VIP mRNA
CTD
PMID:1850078
NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216
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Abcc1
ATP binding cassette subfamily C member 1
multiple interactions
ISO
[Thiethylperazine results in increased activity of ABCC1 protein] which results in increased export of APP protein
CTD
PMID:21881209
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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App
amyloid beta precursor protein
multiple interactions
ISO
[Thiethylperazine results in increased activity of ABCC1 protein] which results in increased export of APP protein
CTD
PMID:21881209
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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Ap1s1
adaptor related protein complex 1 subunit sigma 1
decreases expression
ISO
Thioridazine results in decreased expression of AP1S1 mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr12:19,625,267...19,635,792
Ensembl chr12:19,625,332...19,756,713
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Asah1
N-acylsphingosine amidohydrolase 1
increases expression
ISO
Thioridazine results in increased expression of ASAH1 mRNA
CTD
PMID:17175557
NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233
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Asns
asparagine synthetase (glutamine-hydrolyzing)
increases expression
ISO
Thioridazine results in increased expression of ASNS mRNA
CTD
PMID:17175557
NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
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Casp3
caspase 3
increases activity
ISO
Thioridazine results in increased activity of CASP3 protein
CTD
PMID:21035837
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Ccnd1
cyclin D1
decreases expression
ISO
Thioridazine results in decreased expression of CCND1 protein
CTD
PMID:21035837
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Cdc25a
cell division cycle 25A
increases phosphorylation
ISO
Thioridazine results in increased phosphorylation of CDC25A protein
CTD
PMID:21035837
NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701
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Cdk4
cyclin-dependent kinase 4
decreases expression
ISO
Thioridazine results in decreased expression of CDK4 protein
CTD
PMID:21035837
NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression
ISO
Thioridazine results in increased expression of CDKN1A protein
CTD
PMID:21035837
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cdkn2a
cyclin-dependent kinase inhibitor 2A
increases expression
ISO
Thioridazine results in increased expression of CDKN2A protein
CTD
PMID:21035837
NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
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Ces1d
carboxylesterase 1D
multiple interactions
ISO
Thioridazine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-nitrophenyl acetate]; Thioridazine inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]
CTD
PMID:20097249
NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
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Crh
corticotropin releasing hormone
decreases expression
ISO
Thioridazine results in decreased expression of CRH mRNA
CTD
PMID:16205782
NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
multiple interactions
ISO
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Thioridazine; CYP1A2 protein results in increased metabolism of and results in increased activity of Thioridazine
CTD
PMID:19482014 PMID:23397584
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
multiple interactions decreases activity
ISO
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Thioridazine Thioridazine results in decreased activity of CYP2C19 protein
CTD
PMID:15135088 PMID:23397584
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
multiple interactions
ISO
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Thioridazine; CYP2D6 protein results in increased metabolism of and results in increased activity of Thioridazine
CTD
PMID:19482014 PMID:23397584
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
decreases activity
ISO
Thioridazine results in decreased activity of CYP2E1 protein
CTD
PMID:15135088
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions decreases activity
ISO
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Thioridazine Thioridazine results in decreased activity of CYP3A4 protein
CTD
PMID:15135088 PMID:23397584
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Depp1
DEPP autophagy regulator 1
increases expression
ISO
Thioridazine results in increased expression of DEPP1 mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542
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Eif4ebp1
eukaryotic translation initiation factor 4E binding protein 1
decreases phosphorylation
ISO
Thioridazine results in decreased phosphorylation of EIF4EBP1 protein
CTD
PMID:21035837
NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
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Fabp1
fatty acid binding protein 1
increases expression
ISO
Thioridazine results in increased expression of FABP1 mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
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Fndc4
fibronectin type III domain containing 4
increases expression
ISO
Thioridazine results in increased expression of FNDC4 mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr 6:25,077,155...25,080,812
Ensembl chr 6:25,077,349...25,080,675
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Gdpd3
glycerophosphodiester phosphodiesterase domain containing 3
increases expression
ISO
Thioridazine results in increased expression of GDPD3 mRNA
CTD
PMID:17175557
NCBI chr 1:181,373,505...181,383,063
Ensembl chr 1:181,366,626...181,383,063
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Hpn
hepsin
increases expression
ISO
Thioridazine results in increased expression of HPN mRNA
CTD
PMID:15342952
NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811
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Inhbe
inhibin subunit beta E
increases expression
ISO
Thioridazine results in increased expression of INHBE mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172
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Kcnh2
potassium voltage-gated channel subfamily H member 2
multiple interactions decreases activity
ISO
Thioridazine inhibits the reaction [KCNH2 protein results in increased transport of Thallium] Thioridazine results in decreased activity of KCNH2 protein
CTD
PMID:15671647 PMID:16278312 PMID:21158687 PMID:24052561
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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Lss
lanosterol synthase
increases expression
ISO
Thioridazine results in increased expression of LSS mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762
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Nr0b2
nuclear receptor subfamily 0, group B, member 2
increases expression
ISO
Thioridazine results in increased expression of NR0B2 mRNA
CTD
PMID:17175557
NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
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Nupr1
nuclear protein 1, transcriptional regulator
increases expression
ISO
Thioridazine results in increased expression of NUPR1 mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281
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Phyh
phytanoyl-CoA 2-hydroxylase
increases expression
ISO
Thioridazine results in increased expression of PHYH mRNA
CTD
PMID:15342952
NCBI chr17:73,329,461...73,346,359
Ensembl chr17:73,329,082...73,346,409
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Prl
prolactin
increases expression
ISO
Thioridazine results in increased expression of PRL protein
CTD
PMID:4065553
NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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Serpina3n
serine (or cysteine) peptidase inhibitor, clade A, member 3N
increases expression
ISO
Thioridazine results in increased expression of SERPINA3 mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433
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Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Thioridazine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Slc2a3
solute carrier family 2 member 3
decreases expression
ISO
Thioridazine results in decreased expression of SLC2A3 mRNA
CTD
PMID:15342952
NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472
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Tagln
transgelin
decreases expression
ISO
Thioridazine results in decreased expression of TAGLN mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668
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Tp53
tumor protein p53
affects activity
ISO
Thioridazine affects the activity of TP53 protein
CTD
PMID:35435491
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Wipi1
WD repeat domain, phosphoinositide interacting 1
increases expression
ISO
Thioridazine results in increased expression of WIPI1 mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr10:94,542,946...94,580,174
Ensembl chr10:94,542,946...94,579,846
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Abcb1a
ATP binding cassette subfamily B member 1A
increases activity
ISO
Trifluoperazine results in increased activity of ABCB1 protein
CTD
PMID:2900677
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Ache
acetylcholinesterase
multiple interactions increases activity decreases expression
EXP ISO
energostim inhibits the reaction [Trifluoperazine results in decreased expression of ACHE protein] Trifluoperazine results in increased activity of ACHE protein
CTD
PMID:15232633 PMID:29614332
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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Akt1
AKT serine/threonine kinase 1
multiple interactions
EXP ISO
Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of AKT1 protein]
CTD
PMID:19233221 PMID:21544200
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Atp6v1h
ATPase H+ transporting V1 subunit H
multiple interactions
ISO
[PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of ATP6V1H mRNA
CTD
PMID:28366621
NCBI chr 5:14,379,029...14,484,703
Ensembl chr 5:14,378,257...14,537,962
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Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
Trifluoperazine results in increased expression of BAX protein
CTD
PMID:21475906
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
Trifluoperazine results in decreased expression of BCL2 protein
CTD
PMID:21475906
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Camk2a
calcium/calmodulin-dependent protein kinase II alpha
multiple interactions
EXP
Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of CAMK2A protein]
CTD
PMID:19233221
NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
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Casp3
caspase 3
multiple interactions
EXP ISO
Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased cleavage of and results in increased activity of CASP3 protein]
CTD
PMID:21544200
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cd44
CD44 molecule
multiple interactions
ISO
Trifluoperazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD44 protein]
CTD
PMID:9929743
NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
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Eif4ebp1
eukaryotic translation initiation factor 4E binding protein 1
multiple interactions
EXP ISO
Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of EIF4EBP1 protein]
CTD
PMID:21544200
NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
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Fmo2
flavin containing dimethylaniline monoxygenase 2
increases oxidation
ISO
FMO2 protein results in increased oxidation of Trifluoperazine
CTD
PMID:26062974
NCBI chr13:75,221,149...75,244,377
Ensembl chr13:75,224,402...75,244,308
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Gabbr1
gamma-aminobutyric acid type B receptor subunit 1
multiple interactions
ISO
Trifluoperazine inhibits the reaction [2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]]
CTD
PMID:15627515
NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994
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Gabbr2
gamma-aminobutyric acid type B receptor subunit 2
multiple interactions
ISO
Trifluoperazine inhibits the reaction [2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]]
CTD
PMID:15627515
NCBI chr 5:60,947,517...61,288,104
Ensembl chr 5:60,947,526...61,288,104
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Hif1a
hypoxia inducible factor 1 subunit alpha
decreases expression
ISO
Trifluoperazine results in decreased expression of HIF1A protein
CTD
PMID:18822394
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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Il12b
interleukin 12B
multiple interactions
ISO
Trifluoperazine inhibits the reaction [Hydrogen Peroxide results in decreased expression of IL12B protein]
CTD
PMID:16249388
NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
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Kcnh2
potassium voltage-gated channel subfamily H member 2
multiple interactions
ISO
Trifluoperazine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
CTD
PMID:21158687
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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Kcnn2
potassium calcium-activated channel subfamily N member 2
decreases activity
EXP
Trifluoperazine results in decreased activity of KCNN2 protein
CTD
PMID:10915830
NCBI chr18:37,817,966...38,258,347
Ensembl chr18:37,817,957...38,258,347
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Lamp1
lysosomal-associated membrane protein 1
multiple interactions
ISO
[PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of LAMP1 mRNA
CTD
PMID:28366621
NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883
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Mapk1
mitogen activated protein kinase 1
multiple interactions
EXP ISO
Trifluoperazine inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK1 protein]; Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Trifluoperazine inhibits the reaction [Dinoprost results in increased activity of MAPK1 protein]
CTD
PMID:11914123 PMID:21544200
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk14
mitogen activated protein kinase 14
multiple interactions
ISO EXP
Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK14 protein]
CTD
PMID:21544200
NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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Mapk3
mitogen activated protein kinase 3
multiple interactions
EXP ISO
Trifluoperazine inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK3 protein]; Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Trifluoperazine inhibits the reaction [Dinoprost results in increased activity of MAPK3 protein]
CTD
PMID:11914123 PMID:21544200
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mapk8
mitogen-activated protein kinase 8
multiple interactions
ISO EXP
Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK8 protein]
CTD
PMID:21544200
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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Mapk9
mitogen-activated protein kinase 9
multiple interactions
ISO EXP
Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK9 protein]
CTD
PMID:21544200
NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
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Mt1
metallothionein 1
increases expression
EXP
Trifluoperazine results in increased expression of MT1A mRNA
CTD
PMID:8128501
NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049 Ensembl chr17:10,826,032...10,827,049
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Mtor
mechanistic target of rapamycin kinase
multiple interactions decreases phosphorylation
EXP ISO
Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MTOR protein] Trifluoperazine analog results in decreased phosphorylation of MTOR protein STON2 protein inhibits the reaction [Trifluoperazine analog results in decreased phosphorylation of MTOR protein]
CTD
PMID:21544200 PMID:36702439
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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Myl9
myosin light chain 9
multiple interactions
EXP
Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MYL9 protein]; Trifluoperazine inhibits the reaction [Ionomycin results in increased phosphorylation of MYL9 protein]
CTD
PMID:19233221
NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333
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Nefl
neurofilament light chain
multiple interactions
EXP
Trifluoperazine inhibits the reaction [Rotenone results in decreased expression of NEFL mRNA]
CTD
PMID:31969611
NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793
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Nr3c1
nuclear receptor subfamily 3, group C, member 1
decreases activity
ISO
Trifluoperazine results in decreased activity of NR3C1 protein
CTD
PMID:7887964
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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Parp1
poly (ADP-ribose) polymerase 1
multiple interactions
EXP ISO
Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased cleavage of PARP1 protein]
CTD
PMID:21544200
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Pink1
PTEN induced kinase 1
multiple interactions
ISO
[PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of ATP6V1H mRNA; [PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of LAMP1 mRNA; [PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of TFEB mRNA; PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]; Trifluoperazine affects the reaction [PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] affects the localization of TFEB protein]]
CTD
PMID:28366621
NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635
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Prkn
parkin RBR E3 ubiquitin protein ligase
affects localization multiple interactions
ISO
Trifluoperazine affects the localization of PRKN protein PRKN protein affects the reaction [Trifluoperazine affects the localization of PRKN protein]
CTD
PMID:28366621
NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555
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Prl
prolactin
increases expression
ISO
Trifluoperazine results in increased expression of PRL protein
CTD
PMID:2136057
NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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Rel
REL proto-oncogene, NF-kB subunit
multiple interactions
ISO
Trifluoperazine inhibits the reaction [Hydrogen Peroxide results in decreased localization of REL protein]
CTD
PMID:16249388
NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892
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Rps6kb1
ribosomal protein S6 kinase B1
multiple interactions
EXP ISO
Trifluoperazine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]
CTD
PMID:21544200
NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
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Slc5a6
solute carrier family 5 member 6
multiple interactions
ISO
Trifluoperazine inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]
CTD
PMID:15561972
NCBI chr 6:25,319,187...25,331,713
Ensembl chr 6:25,320,442...25,331,712
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Ston2
stonin 2
decreases expression multiple interactions
ISO
Trifluoperazine analog results in decreased expression of STON2 protein STON2 protein inhibits the reaction [Trifluoperazine analog results in decreased phosphorylation of MTOR protein]
CTD
PMID:36702439
NCBI chr 6:110,567,485...110,676,376
Ensembl chr 6:110,567,485...110,676,376
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Tfeb
transcription factor EB
multiple interactions
ISO
[PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of TFEB mRNA; Trifluoperazine affects the reaction [PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] affects the localization of TFEB protein]]
CTD
PMID:28366621
NCBI chr 9:13,198,890...13,254,726
Ensembl chr 9:13,198,891...13,254,714
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Tnfsf11
TNF superfamily member 11
decreases activity
ISO
Trifluoperazine results in decreased activity of TNFSF11
CTD
PMID:21869564
NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445
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Ugt1a5
UDP glucuronosyltransferase family 1 member A5
increases glucuronidation multiple interactions increases activity
ISO
UGT1A4 protein results in increased glucuronidation of Trifluoperazine Finasteride inhibits the reaction [UGT1A4 protein results in increased glucuronidation of Trifluoperazine]; hecogenin inhibits the reaction [UGT1A4 protein results in increased glucuronidation of Trifluoperazine]; licochalcone A inhibits the reaction [Trifluoperazine results in increased activity of UGT1A4 protein]; Trifluoperazine inhibits the reaction [UGT1A4 protein results in increased glucuronidation of afloqualone]
CTD
PMID:15135306 PMID:15475412 PMID:25393417 PMID:25448279 PMID:26875642 PMID:33290829 More...
NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Kcnh2
potassium voltage-gated channel subfamily H member 2
decreases activity
ISO
Triflupromazine results in decreased activity of KCNH2 protein
CTD
PMID:28551711
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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