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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:lithium carbonate
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Accession:CHEBI:6504 term browser browse the term
Definition:A carbonate salt that has formula CO3.2Li.
Synonyms:exact_synonym: dilithium trioxidocarbonate
 related_synonym: Formula=CLi2O3;   Formula=CO3.2Li;   InChI=1S/CH2O3.2Li/c2-1(3)4;;/h(H2,2,3,4);;/q;2*+1/p-2;   InChIKey=XGZVUEUWXADBQD-UHFFFAOYSA-L;   Li2CO3;   SMILES=[Li+].[Li+].[O-]C([O-])=O;   carbonic acid, dilithium salt;   dilithium carbonate
 xref: Beilstein:3999191;   CAS:554-13-2;   Gmelin:1123452;   Gmelin:23965;   KEGG:C07964;   KEGG:D00801
 xref_mesh: MESH:D016651
 xref: Wikipedia:Lithium_Carbonate


show annotations for term's descendants           Sort by:
lithium carbonate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase multiple interactions
decreases activity		 EXP Lithium Carbonate promotes the reaction [sodium arsenite results in decreased activity of ALAD protein]; sodium arsenite promotes the reaction [Lithium Carbonate results in decreased activity of ALAD protein]; Zinc Sulfate inhibits the reaction [Lithium Carbonate results in decreased activity of ALAD protein] CTD PMID:19083387 PMID:28988373 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474 		JBrowse link
G Casp1 caspase 1 increases expression ISO Lithium Carbonate results in increased expression of CASP1 protein CTD PMID:34984798 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases expression		 EXP
ISO		 Lithium Carbonate results in increased activity of CASP3 protein
Butylated Hydroxytoluene inhibits the reaction [Lithium Carbonate results in increased activity of CASP3 protein]; Cyclosporine inhibits the reaction [Lithium Carbonate results in increased activity of CASP3 protein]
Lithium Carbonate results in increased expression of CASP3 protein		 CTD PMID:27588890 PMID:34984798 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp6 caspase 6 increases expression ISO Lithium Carbonate results in increased expression of CASP6 protein CTD PMID:34984798 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502 		JBrowse link
G Casp7 caspase 7 increases expression ISO Lithium Carbonate results in increased expression of CASP7 protein CTD PMID:34984798 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp9 caspase 9 increases expression ISO Lithium Carbonate results in increased expression of CASP9 protein CTD PMID:34984798 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase decreases activity
multiple interactions		 EXP
ISO		 Lithium Carbonate results in decreased activity of CAT protein
Lithium Carbonate promotes the reaction [sodium arsenite results in decreased activity of CAT protein]; sodium arsenite promotes the reaction [Lithium Carbonate results in decreased activity of CAT protein]		 CTD PMID:28988373 PMID:34984798 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
decreases activity		 EXP Lithium Carbonate promotes the reaction [sodium arsenite results in decreased activity of GSR protein]; sodium arsenite promotes the reaction [Lithium Carbonate results in decreased activity of GSR protein] CTD PMID:28988373 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Ifng interferon gamma multiple interactions ISO [Lithium Carbonate co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IFNG mRNA CTD PMID:29594315 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il1b interleukin 1 beta decreases expression
increases expression		 ISO Lithium Carbonate results in decreased expression of IL1B mRNA
Lithium Carbonate results in increased expression of IL1B mRNA; Lithium Carbonate results in increased expression of IL1B protein		 CTD PMID:29594315 PMID:34984798 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Lithium Carbonate co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA CTD PMID:29594315 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Ins1 insulin 1 decreases expression
multiple interactions		 EXP Lithium Carbonate results in decreased expression of INS1 protein
Lithium Carbonate inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]		 CTD PMID:10700396 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Nfkbia NFKB inhibitor alpha increases phosphorylation ISO Lithium Carbonate results in increased phosphorylation of NFKBIA protein CTD PMID:34984798 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 increases expression ISO Lithium Carbonate results in increased expression of NLRP3 protein CTD PMID:34984798 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Pfkfb2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 decreases activity
multiple interactions		 EXP Lithium Carbonate results in decreased activity of PFKFB2 protein
Lithium Carbonate inhibits the reaction [Streptozocin results in decreased activity of PFKFB2 protein]		 CTD PMID:10700396 NCBI chr13:42,147,473...42,174,699
Ensembl chr13:42,147,478...42,174,699 		JBrowse link
G Pla2g4a phospholipase A2 group IVA increases expression ISO Lithium Carbonate results in increased expression of PLA2G4A mRNA; Lithium Carbonate results in increased expression of PLA2G4A protein CTD PMID:17594078 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266 		JBrowse link
G Pth parathyroid hormone increases expression ISO Lithium Carbonate results in increased expression of PTH protein CTD PMID:3083797 PMID:18234408 NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530 		JBrowse link
G Pycard PYD and CARD domain containing increases expression ISO Lithium Carbonate results in increased expression of PYCARD protein CTD PMID:34984798 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases phosphorylation ISO Lithium Carbonate results in increased phosphorylation of RELA protein CTD PMID:34984798 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tnf tumor necrosis factor increases expression ISO Lithium Carbonate results in increased expression of TNF mRNA; Lithium Carbonate results in increased expression of TNF protein CTD PMID:34984798 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    chemical entity 19840
      atom 19809
        main group element atom 19759
          alkali metal atom 12811
            lithium atom 545
              lithium molecular entity 359
                lithium salt 358
                  lithium carbonate 20
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            heteroorganic entity 19459
                              organochalcogen compound 19222
                                organooxygen compound 19137
                                  carbon oxoacid 18597
                                    carbonic acid 5603
                                      carbonates 136
                                        carbonate salt 25
                                          lithium carbonate 20
paths to the root