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Pathways

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 3.1.1.3 (triacylglycerol lipase) inhibitor
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Accession:CHEBI:65001 term browser browse the term
Definition:Any EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that inhibits the action of triacylglycerol lipase (EC 3.1.1.3).
Synonyms:related_synonym: EC 3.1.1.3 (triacylglycerol lipase) inhibitors;   EC 3.1.1.3 inhibitor;   EC 3.1.1.3 inhibitors;   GEH inhibitor;   GEH inhibitors;   PPL inhibitor;   PPL inhibitors;   Tween hydrolase inhibitor;   Tween hydrolase inhibitors;   Tweenase inhibitor;   Tweenase inhibitors;   Tweenesterase inhibitor;   Tweenesterase inhibitors;   butyrinase inhibitor;   butyrinase inhibitors;   cacordase inhibitor;   cacordase inhibitors;   capalase L inhibitor;   capalase L inhibitors;   glycerol-ester hydrolase inhibitor;   glycerol-ester hydrolase inhibitors;   heparin releasable hepatic lipase inhibitor;   heparin releasable hepatic lipase inhibitors;   hepatic lipase inhibitor;   hepatic lipase inhibitors;   hepatic monoacylglycerol acyltransferase inhibitor;   hepatic monoacylglycerol acyltransferase inhibitors;   lipase inhibitor;   lipase inhibitors;   lipazin inhibitor;   lipazin inhibitors;   liver lipase inhibitor;   liver lipase inhibitors;   pancreatic lipase inhibitor;   pancreatic lipase inhibitors;   pancreatic triacylglycerol lipase inhibitor;   pancreatic triacylglycerol lipase inhibitors;   post-heparin plasma protamine-resistant lipase inhibitor;   post-heparin plasma protamine-resistant lipase inhibitors;   salt-resistant post-heparin lipase inhibitor;   salt-resistant post-heparin lipase inhibitors;   steapsin inhibitor;   steapsin inhibitors;   triacetinase inhibitor;   triacetinase inhibitors;   triacylglycerol ester hydrolase inhibitor;   triacylglycerol ester hydrolase inhibitors;   triacylglycerol lipase inhibitor;   triacylglycerol lipase inhibitors;   tributyrase inhibitor;   tributyrase inhibitors;   tributyrin esterase inhibitor;   tributyrin esterase inhibitors;   tributyrinase inhibitor;   tributyrinase inhibitors;   triglyceridase inhibitor;   triglyceridase inhibitors;   triglyceride hydrolase inhibitor;   triglyceride hydrolase inhibitors;   triglyceride lipase inhibitor;   triglyceride lipase inhibitors;   triolein hydrolase inhibitor;   triolein hydrolase inhibitors;   tween-hydrolysing esterase inhibitor;   tween-hydrolyzing esterase inhibitors



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benzaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b15 aldo-keto reductase family 1 member B15 multiple interactions EXP [AKR1B8 protein co-treated with NADP] affects the reduction of benzaldehyde CTD PMID:18845131 NCBI chr 4:63,964,421...63,976,995
Ensembl chr 4:63,960,880...63,978,349
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases oxidation
increases metabolic processing
EXP
ISO
ALDH1A1 protein results in increased oxidation of benzaldehyde
ALDH1A1 protein results in increased metabolism of benzaldehyde
CTD PMID:10998257 PMID:21256123 NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:227,427,070...227,579,500
JBrowse link
G Aldh1a7 aldehyde dehydrogenase family 1, subfamily A7 increases oxidation EXP ALDH1A7 protein results in increased oxidation of benzaldehyde CTD PMID:10998257 NCBI chr 1:227,627,977...227,667,877
Ensembl chr 1:227,627,448...227,672,523
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member increases metabolic processing
multiple interactions
ISO ALDH2 protein results in increased metabolism of benzaldehyde
benzaldehyde inhibits the reaction [4-dimethylaminocinnamaldehyde binds to ALDH2 protein]
CTD PMID:10609638 PMID:11744614 NCBI chr12:40,610,244...40,643,220
Ensembl chr12:40,610,224...40,643,219
JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 multiple interactions
increases oxidation
increases metabolic processing
ISO [ALDH3A1 protein co-treated with NAD] results in increased oxidation of benzaldehyde; [ALDH3A1 protein co-treated with NADP] results in increased oxidation of benzaldehyde; Cimetidine inhibits the reaction [ALDH3A1 protein results in increased oxidation of benzaldehyde]
ALDH3A1 protein results in increased metabolism of benzaldehyde
CTD PMID:10856427 PMID:21256123 PMID:21349255 PMID:23220590 PMID:25512087 NCBI chr10:46,392,464...46,402,151
Ensembl chr10:46,392,411...46,402,151
JBrowse link
G Aldh3b1 aldehyde dehydrogenase 3 family, member B1 affects binding ISO benzaldehyde binds to ALDH3B1 protein CTD PMID:20699116 NCBI chr 1:210,574,545...210,605,188
Ensembl chr 1:210,573,661...210,610,538
JBrowse link
G Ar androgen receptor multiple interactions EXP benzaldehyde inhibits the reaction [Metribolone binds to AR protein] CTD PMID:3695475 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:67,135,317...67,304,467
JBrowse link
G Or8a1b olfactory receptor family 8 subfamily A member 1B multiple interactions ISO benzaldehyde binds to and results in increased activity of OR8A1 protein CTD PMID:11943806 NCBI chr 8:45,623,650...45,624,579
Ensembl chr 8:45,623,650...45,624,579
JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases activity
multiple interactions
ISO benzaldehyde results in increased activity of SLC2A1 protein
[benzaldehyde co-treated with Glucose deficiency] results in decreased activity of SLC2A1 protein
CTD PMID:20955755 NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:138,002,522...138,030,742
JBrowse link
benzoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp1 acid phosphatase 1 decreases activity
multiple interactions
ISO Benzoic Acid analog results in decreased activity of ACP1 protein
Benzoic Acid analog inhibits the reaction [ACP1 protein results in increased hydrolysis of nitrophenylphosphate]
CTD PMID:24287560 NCBI chr 6:53,233,937...53,249,576
Ensembl chr 6:53,233,948...53,251,959
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 increases expression ISO Benzoic Acid results in increased expression of AKR1B1 mRNA CTD PMID:20566472 NCBI chr 4:63,899,222...63,913,315
Ensembl chr 4:63,899,222...63,913,315
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO Benzoic Acid results in increased expression of AKR1B10 mRNA CTD PMID:20566472 NCBI chr 4:64,005,632...64,027,860
Ensembl chr 4:64,007,420...64,020,847
JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 increases expression ISO Benzoic Acid results in increased expression of AKR1C1 mRNA CTD PMID:20566472 NCBI chr17:70,720,397...70,747,285
Ensembl chr17:70,720,398...70,747,247
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases expression ISO Benzoic Acid results in increased expression of AKR1C3 mRNA CTD PMID:20566472 NCBI chr17:71,020,884...71,037,779
Ensembl chr17:70,970,900...71,048,438
JBrowse link
G Bche butyrylcholinesterase increases abundance
increases chemical synthesis
multiple interactions
ISO BCHE protein mutant form results in increased abundance of Benzoic Acid
BCHE protein mutant form results in increased chemical synthesis of Benzoic Acid
[BCHE protein mutant form results in increased metabolism of Cocaine] which results in increased chemical synthesis of Benzoic Acid
[BCHE protein mutant form results in increased hydrolysis of Cocaine] which results in increased abundance of Benzoic Acid
CTD PMID:25814464 PMID:30080993 NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO Benzoic Acid analog inhibits the reaction [STAT3 protein binds to BCL2 promoter] CTD PMID:26088127 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO Benzoic Acid analog inhibits the reaction [STAT3 protein binds to BIRC5 promoter] CTD PMID:26088127 NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155
JBrowse link
G Cat catalase multiple interactions
decreases activity
ISO Quercetin inhibits the reaction [Benzoic Acid results in decreased activity of CAT protein] CTD PMID:24745150 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Benzoic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL2 protein] CTD PMID:36416909 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO Benzoic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL3 protein] CTD PMID:36416909 NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO Benzoic Acid analog results in decreased activity of [CCND1 protein binds to CDK4 protein]
Benzoic Acid analog results in decreased expression of CCND1 protein
CTD PMID:10403840 PMID:26088127 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810
JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions ISO Benzoic Acid analog results in decreased activity of [CCND1 protein binds to CDK4 protein] CTD PMID:10403840 NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163
JBrowse link
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP [COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Benzoic Acid CTD PMID:24709313 NCBI chr 7:130,977,561...131,006,627
Ensembl chr 7:130,977,561...131,006,627
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [Amiodarone co-treated with Benzoic Acid co-treated with cyproconazole co-treated with flusilazole co-treated with enilconazole co-treated with prochloraz co-treated with propiconazole co-treated with tebuconazole] results in increased expression of CYP3A4 protein CTD PMID:34273450 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
JBrowse link
G Egf epidermal growth factor multiple interactions ISO Benzoic Acid analog inhibits the reaction [EGF protein promotes the reaction [STAT3 protein binds to EGFR protein]]; Benzoic Acid analog inhibits the reaction [EGF protein results in increased phosphorylation of STAT3 protein] CTD PMID:26088127 NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:220,893,660...220,976,297
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Benzoic Acid analog inhibits the reaction [EGF protein promotes the reaction [STAT3 protein binds to EGFR protein]] CTD PMID:26088127 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358
JBrowse link
G Epha4 Eph receptor A4 multiple interactions ISO Benzoic Acid analog inhibits the reaction [Adenosine Diphosphate results in increased phosphorylation of EPHA4 protein]; Benzoic Acid analog inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY results in increased phosphorylation of EPHA4 protein] CTD PMID:22273509 NCBI chr 9:86,263,982...86,406,744
Ensembl chr 9:86,263,982...86,406,755
JBrowse link
G Fech ferrochelatase increases expression ISO Benzoic Acid results in increased expression of FECH mRNA CTD PMID:20566472 NCBI chr18:60,215,325...60,248,525
Ensembl chr18:60,215,325...60,249,546
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO Benzoic Acid results in increased expression of FOSL1 protein CTD PMID:20025956 NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:212,183,833...212,192,391
JBrowse link
G Ftl1 ferritin light chain 1 increases expression ISO Benzoic Acid results in increased expression of FTL mRNA CTD PMID:20566472 NCBI chr 1:105,072,858...105,074,705
Ensembl chr  X:45,399,355...45,399,915
Ensembl chr 2:45,399,355...45,399,915
Ensembl chr 1:45,399,355...45,399,915
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases expression ISO Benzoic Acid results in increased expression of G6PD mRNA CTD PMID:20566472 NCBI chr  X:157,352,364...157,372,144
Ensembl chr  X:157,352,373...157,372,144
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO Benzoic Acid results in increased expression of GCLC mRNA CTD PMID:20566472 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Benzoic Acid results in increased expression of GCLM mRNA CTD PMID:20566472 NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003
JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity EXP Benzoic Acid results in increased activity of GPT protein CTD PMID:29981020 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160
JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO Benzoic Acid results in increased expression of GSR mRNA CTD PMID:20566472 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 increases activity ISO Benzoic Acid results in increased activity of GSTA1 protein mutant form CTD PMID:10329179 NCBI chr 9:31,199,887...31,216,606
Ensembl chr 9:31,199,888...31,211,528
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Benzoic Acid results in increased expression of HMOX1 mRNA CTD PMID:20566472 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818
JBrowse link
G Il12b interleukin 12B multiple interactions ISO Benzoic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL12B protein] CTD PMID:36416909 NCBI chr10:29,390,300...29,405,194
Ensembl chr10:29,389,905...29,405,194
JBrowse link
G Il1a interleukin 1 alpha increases expression
increases secretion
ISO Benzoic Acid results in increased expression of IL1A mRNA
Benzoic Acid results in increased secretion of IL1A protein
CTD PMID:12781210 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 increases expression ISO Benzoic Acid results in increased expression of IL1RL1 protein CTD PMID:20025956 NCBI chr 9:50,157,326...50,222,888
Ensembl chr 9:50,204,551...50,222,891
JBrowse link
G Il4i1 interleukin 4 induced 1 decreases activity ISO Benzoic Acid results in decreased activity of IL4I1 protein CTD PMID:15383589 NCBI chr 1:104,435,540...104,461,049
Ensembl chr 1:104,435,981...104,461,053
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Benzoic Acid analog inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein] CTD PMID:26088127 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
JBrowse link
G Insr insulin receptor increases phosphorylation ISO Benzoic Acid analog results in increased phosphorylation of INSR protein CTD PMID:24287560 NCBI chr12:5,991,135...6,129,275
Ensembl chr12:5,981,835...6,128,803
JBrowse link
G Mafg MAF bZIP transcription factor G increases expression ISO Benzoic Acid results in increased expression of MAFG mRNA CTD PMID:20566472 NCBI chr10:106,401,633...106,410,159 JBrowse link
G Me1 malic enzyme 1 increases expression ISO Benzoic Acid results in increased expression of ME1 mRNA CTD PMID:20566472 NCBI chr 8:96,429,057...96,540,244
Ensembl chr 8:96,429,057...96,540,275
JBrowse link
G Mpo myeloperoxidase increases activity ISO Benzoic Acid results in increased activity of MPO protein CTD PMID:24060682 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056
JBrowse link
G Mt1a metallothionein 1A increases expression ISO Benzoic Acid results in increased expression of MT1A mRNA CTD PMID:20491607 NCBI chr19:10,831,959...10,832,975
Ensembl chr17:79,695,809...79,696,200
Ensembl chr  X:79,695,809...79,696,200
Ensembl chr19:79,695,809...79,696,200
JBrowse link
G Mt2 metallothionein 2 increases expression ISO Benzoic Acid results in increased expression of MT2A mRNA CTD PMID:20491607 NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,837,927...10,838,709
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
decreases expression
ISO [MYC protein results in increased expression of SLC16A1 protein] which results in increased import of Benzoic Acid
Benzoic Acid analog results in decreased expression of MYC protein
CTD PMID:19239227 PMID:26088127 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Benzoic Acid analog inhibits the reaction [STAT3 protein binds to NOS2 promoter] CTD PMID:26088127 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
JBrowse link
G Nos3 nitric oxide synthase 3 increases expression ISO Benzoic Acid results in increased expression of NOS3 mRNA CTD PMID:15740983 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO Benzoic Acid results in increased expression of NQO1 mRNA CTD PMID:20566472 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260
JBrowse link
G Pf4 platelet factor 4 multiple interactions ISO Benzoic Acid analog inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY results in increased secretion of PF4 protein] CTD PMID:22273509 NCBI chr14:17,582,477...17,583,392
Ensembl chr14:17,582,477...17,583,392
JBrowse link
G Pgd phosphogluconate dehydrogenase increases expression ISO Benzoic Acid results in increased expression of PGD mRNA CTD PMID:20566472 NCBI chr 5:164,865,830...164,882,029
Ensembl chr 5:164,865,830...164,882,029
JBrowse link
G Ptgr1 prostaglandin reductase 1 increases expression ISO Benzoic Acid results in increased expression of PTGR1 mRNA CTD PMID:20566472 NCBI chr 5:78,579,060...78,597,671
Ensembl chr 5:78,579,057...78,597,811
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases activity
ISO Benzoic Acid inhibits the reaction [PTGS2 protein results in increased metabolism of Arachidonic Acid]
Benzoic Acid results in decreased activity of PTGS2 protein
CTD PMID:12538810 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 multiple interactions
decreases activity
ISO Benzoic Acid analog inhibits the reaction [PTPN1 protein results in increased hydrolysis of nitrophenylphosphate]
Benzoic Acid analog results in decreased activity of PTPN1 protein
CTD PMID:24287560 NCBI chr 3:177,056,588...177,106,424
Ensembl chr 3:177,057,659...177,106,416
JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 multiple interactions
decreases activity
ISO Benzoic Acid analog inhibits the reaction [PTPN2 protein results in increased hydrolysis of nitrophenylphosphate]
Benzoic Acid analog results in decreased activity of PTPN2 protein
CTD PMID:24287560 NCBI chr18:63,498,890...63,564,571
Ensembl chr18:63,498,890...63,564,481
JBrowse link
G Slc15a1 solute carrier family 15 member 1 affects binding ISO Benzoic Acid analog binds to SLC15A1 protein CTD PMID:21147219 NCBI chr15:104,944,461...104,991,316
Ensembl chr15:104,944,463...104,989,369
JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions
increases transport
increases import
increases export
increases uptake
ISO
EXP
[MYC protein results in increased expression of SLC16A1 protein] which results in increased import of Benzoic Acid; Benzoic Acid inhibits the reaction [SLC16A1 protein results in increased uptake of Lactic Acid]; morin inhibits the reaction [SLC16A1 protein results in increased uptake of Benzoic Acid]; naringenin inhibits the reaction [SLC16A1 protein results in increased uptake of Benzoic Acid]; Quercetin inhibits the reaction [SLC16A1 protein results in increased uptake of Benzoic Acid]; silybin inhibits the reaction [SLC16A1 protein results in increased uptake of Benzoic Acid]
SLC16A1 protein results in increased transport of Benzoic Acid
SLC16A1 protein results in increased import of Benzoic Acid
SLC16A1 protein results in increased export of Benzoic Acid
Acetic Acid inhibits the reaction [SLC16A1 protein results in increased transport of Benzoic Acid]; Butyric Acid inhibits the reaction [SLC16A1 protein results in increased transport of Benzoic Acid]; Foscarnet inhibits the reaction [SLC16A1 protein results in increased transport of Benzoic Acid]; mandelic acid inhibits the reaction [SLC16A1 protein results in increased transport of Benzoic Acid]; propionic acid inhibits the reaction [SLC16A1 protein results in increased transport of Benzoic Acid]; Protons inhibits the reaction [SLC16A1 protein results in increased export of Benzoic Acid]; Protons promotes the reaction [SLC16A1 protein results in increased import of Benzoic Acid]; Salicylic Acid inhibits the reaction [SLC16A1 protein results in increased transport of Benzoic Acid]
CTD PMID:10579682 PMID:10714609 PMID:15804185 PMID:17976262 PMID:19239227 NCBI chr 2:194,805,556...194,832,966
Ensembl chr 2:194,812,502...194,832,977
JBrowse link
G Slc22a7 solute carrier family 22 member 7 multiple interactions ISO
EXP
[Orotic Acid co-treated with Benzoic Acid] promotes the reaction [SLC22A7 protein results in increased export of Orotic Acid]; Benzoic Acid promotes the reaction [SLC22A7 protein results in increased export of Orotic Acid] CTD PMID:22981274 NCBI chr 9:22,044,672...22,052,051
Ensembl chr 9:22,045,435...22,051,681
JBrowse link
G Slc4a2 solute carrier family 4 member 2 multiple interactions
increases uptake
ISO 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [SLC4A2 protein results in increased uptake of Benzoic Acid]; Bicarbonates inhibits the reaction [SLC4A2 protein results in increased uptake of Benzoic Acid]; Chlorides inhibits the reaction [SLC4A2 protein results in increased uptake of Benzoic Acid] CTD PMID:9563070 NCBI chr 4:11,628,860...11,646,961
Ensembl chr 4:11,628,862...11,645,402
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Benzoic Acid results in increased expression of SRXN1 mRNA CTD PMID:20566472 NCBI chr 3:161,064,812...161,070,372
Ensembl chr 3:161,059,931...161,088,765
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Benzoic Acid analog inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]; Benzoic Acid analog inhibits the reaction [STAT3 protein binds to BCL2 promoter]; Benzoic Acid analog inhibits the reaction [STAT3 protein binds to BIRC5 promoter]; Benzoic Acid analog inhibits the reaction [STAT3 protein binds to NOS2 promoter]; Benzoic Acid analog results in decreased phosphorylation of and results in decreased activity of STAT3 protein
Benzoic Acid analog inhibits the reaction [EGF protein promotes the reaction [STAT3 protein binds to EGFR protein]]; Benzoic Acid analog inhibits the reaction [EGF protein results in increased phosphorylation of STAT3 protein]; Benzoic Acid analog results in decreased phosphorylation of and results in decreased activity of STAT3 protein
CTD PMID:26088127 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Benzoic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein] CTD PMID:36416909 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
G Txn1 thioredoxin 1 increases expression ISO Benzoic Acid results in increased expression of TXN mRNA CTD PMID:20491607 NCBI chr 5:77,507,455...77,519,685
Ensembl chr 5:77,507,321...77,520,307
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO Benzoic Acid results in increased expression of TXNRD1 mRNA CTD PMID:20566472 NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:22,719,317...22,739,817
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO Benzoic Acid results in increased expression of VEGFA protein CTD PMID:20025956 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194
JBrowse link
carboxy-PTIO term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 increases expression
multiple interactions
ISO 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole results in increased expression of ATF4 mRNA
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of ATF4 mRNA]
CTD PMID:21703327 NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Nitric Oxide results in increased nitrosation of and results in decreased degradation of BCL2 protein]; 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole results in decreased nitrosation of and results in increased ubiquitination of and results in increased degradation of BCL2 protein; [1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole results in decreased nitrosation of and results in increased ubiquitination of and results in increased degradation of BCL2 protein] which results in increased susceptibility to Chromates CTD PMID:16980304 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate results in decreased expression of BIRC5 protein] CTD PMID:35985571 NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155
JBrowse link
G Casp3 caspase 3 multiple interactions ISO 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Bortezomib results in increased cleavage of CASP3 protein]; 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Chloroquine results in increased cleavage of CASP3 protein]; 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Nitroprusside results in increased cleavage of CASP3 protein] CTD PMID:30482226 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
JBrowse link
G Cav1 caveolin 1 decreases expression ISO 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole results in decreased expression of CAV1 protein CTD PMID:19706615 NCBI chr 4:46,606,538...46,639,616
Ensembl chr 4:46,600,738...46,639,740
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate results in decreased expression of CCND1 protein] CTD PMID:35985571 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810
JBrowse link
G Cd28 Cd28 molecule multiple interactions ISO 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [CD28 protein results in increased abundance of Calcium]; 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [CD28 protein results in increased abundance of Nitric Oxide]; 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [CD28 protein results in increased abundance of Reactive Oxygen Species] CTD PMID:14607919 NCBI chr 9:69,660,316...69,689,192
Ensembl chr 9:69,545,326...69,689,192
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate results in increased expression of CDH1 protein] CTD PMID:35985571 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions ISO 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CEBPB protein alternative form]; 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Nitroprusside results in increased expression of CEBPB protein alternative form]
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of CEBPB protein alternative form]; 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Nitroprusside results in increased expression of CEBPB protein alternative form]
CTD PMID:30482226 NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:176,816,859...176,838,072
JBrowse link
G Cldn5 claudin 5 multiple interactions ISO 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [9,10-phenanthrenequinone results in decreased expression of CLDN5 protein] CTD PMID:34391839 NCBI chr11:95,717,172...95,718,598
Ensembl chr11:95,717,176...95,719,322
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate results in decreased expression of and results in increased phosphorylation of CTNNB1 protein] CTD PMID:35985571 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions
ISO 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole results in increased expression of DDIT3 mRNA
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Nitroprusside results in increased expression of DDIT3 protein]
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Nitroprusside results in increased expression of DDIT3 protein]; 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of DDIT3 mRNA]
CTD PMID:21703327 PMID:30482226 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate results in decreased phosphorylation of GSK3B protein] CTD PMID:35985571 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate results in decreased expression of MYC protein] CTD PMID:35985571 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028
JBrowse link
G Ptgis prostaglandin I2 synthase decreases activity EXP cPTIO decreases activity of Ptgis protein in the aorta RGD PMID:12964126 RGD:401960074 NCBI chr 3:176,347,589...176,383,251
Ensembl chr 3:176,335,437...176,407,650
JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions ISO 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate results in decreased expression of SNAI1 protein] CTD PMID:35985571 NCBI chr 3:176,667,476...176,671,965 JBrowse link
G Snai2 snail family transcriptional repressor 2 multiple interactions ISO 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate results in decreased expression of SNAI2 protein] CTD PMID:35985571 NCBI chr11:99,686,934...99,690,349
Ensembl chr11:99,686,934...99,690,349
JBrowse link
G Tnfsf10 TNF superfamily member 10 decreases response to substance
multiple interactions
ISO 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole results in decreased susceptibility to TNFSF10 protein
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [TNFSF10 protein results in increased abundance of Reactive Nitrogen Species]
CTD PMID:20971099 NCBI chr 2:112,136,550...112,155,903 JBrowse link
G Trib3 tribbles pseudokinase 3 multiple interactions ISO 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of TRIB3 protein]; 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Nitroprusside results in increased expression of TRIB3 protein] CTD PMID:30482226 NCBI chr 3:161,269,939...161,275,533
Ensembl chr 3:161,269,955...161,274,802
JBrowse link
G Vim vimentin multiple interactions ISO 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate results in decreased expression of VIM protein] CTD PMID:35985571 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746
JBrowse link
galangin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
increases activity
multiple interactions
ISO galangin results in increased expression of ABCB1 mRNA; galangin results in increased expression of ABCB1 protein
galangin results in increased activity of ABCB1 protein
galangin inhibits the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]]; Verapamil promotes the reaction [galangin results in increased activity of ABCB1 protein]
CTD PMID:26238175 PMID:34217736 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 decreases activity ISO galangin results in decreased activity of ABCC1 protein CTD PMID:15670588 NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404
JBrowse link
G Ache acetylcholinesterase decreases activity EXP galangin results in decreased activity of ACHE protein CTD PMID:20452337 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410
JBrowse link
G Ahr aryl hydrocarbon receptor increases activity
multiple interactions
affects localization
ISO galangin results in increased activity of AHR protein
galangin affects the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; galangin binds to and results in decreased activity of AHR protein; galangin binds to and results in increased activity of AHR protein; galangin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene affects the localization of AHR protein]; galangin inhibits the reaction [Benzo(a)pyrene affects the localization of AHR protein]; galangin inhibits the reaction [Benzo(a)pyrene results in increased expression of AHR mRNA]; galangin inhibits the reaction [Benzo(a)pyrene results in increased expression of AHR protein]; galangin inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of AHR protein]; galangin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; galangin inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of AHR protein]
galangin affects the localization of AHR protein
CTD PMID:10953044 PMID:14644660 PMID:17090139 PMID:20435555 PMID:20450880 More... NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO galangin results in decreased phosphorylation of AKT1 protein CTD PMID:18455702 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO galangin inhibits the reaction [Benzo(a)pyrene results in increased expression of ARNT mRNA]; galangin inhibits the reaction [Benzo(a)pyrene results in increased expression of ARNT protein] CTD PMID:33663268 NCBI chr 2:185,686,703...185,745,546
Ensembl chr 2:185,680,683...185,745,546
JBrowse link
G Atg12 autophagy related 12 increases expression
multiple interactions
ISO galangin results in increased expression of ATG12 mRNA; galangin results in increased expression of ATG12 protein
[ATG12 mutant form co-treated with galangin] results in decreased activity of CASP3 protein; LY2109761 inhibits the reaction [galangin results in increased expression of ATG12 protein]; SMAD4 mutant form inhibits the reaction [galangin results in increased expression of ATG12 protein]
CTD PMID:25268046 NCBI chr18:41,638,841...41,649,311
Ensembl chr18:41,635,835...41,649,261
JBrowse link
G Atg16l1 autophagy related 16-like 1 multiple interactions
increases expression
ISO [ATG16L1 mutant form co-treated with galangin] results in decreased activity of CASP3 protein; LY2109761 inhibits the reaction [galangin results in increased expression of ATG16L1 protein]; SMAD4 mutant form inhibits the reaction [galangin results in increased expression of ATG16L1 protein]
galangin results in increased expression of ATG16L1 mRNA; galangin results in increased expression of ATG16L1 protein
CTD PMID:25268046 NCBI chr 9:95,869,839...95,905,354
Ensembl chr 9:95,869,865...95,905,357
JBrowse link
G Atg3 autophagy related 3 multiple interactions
increases expression
ISO [ATG3 mutant form co-treated with galangin] results in decreased activity of CASP3 protein; LY2109761 inhibits the reaction [galangin results in increased expression of ATG3 protein]; SMAD4 mutant form inhibits the reaction [galangin results in increased expression of ATG3 protein]
galangin results in increased expression of ATG3 mRNA; galangin results in increased expression of ATG3 protein
CTD PMID:25268046 NCBI chr11:69,130,948...69,159,280
Ensembl chr11:69,121,952...69,159,280
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO galangin results in increased expression of BAX protein CTD PMID:25450235 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO galangin results in decreased expression of BCL2 protein CTD PMID:25450235 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO galangin results in decreased expression of BCL2L1 protein CTD PMID:25450235 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP galangin inhibits the reaction [Doxorubicin results in decreased expression of BDNF protein] CTD PMID:35843304 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657
JBrowse link
G Becn1 beclin 1 multiple interactions
increases expression
ISO [BECN1 mutant form co-treated with galangin] results in decreased activity of CASP3 protein; LY2109761 inhibits the reaction [galangin results in increased expression of BECN1 protein]; SMAD4 mutant form inhibits the reaction [galangin results in increased expression of BECN1 protein]
galangin results in increased expression of BECN1 mRNA; galangin results in increased expression of BECN1 protein
CTD PMID:25268046 NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,731,650...86,747,002
JBrowse link
G Casp1 caspase 1 multiple interactions ISO
EXP
galangin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased activity of CASP1 protein]
galangin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of and results in increased activity of CASP1 protein]
CTD PMID:23535185 PMID:35384154 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
ISO [ATG12 mutant form co-treated with galangin] results in decreased activity of CASP3 protein; [ATG16L1 mutant form co-treated with galangin] results in decreased activity of CASP3 protein; [ATG3 mutant form co-treated with galangin] results in decreased activity of CASP3 protein; [BECN1 mutant form co-treated with galangin] results in decreased activity of CASP3 protein
galangin results in increased cleavage of CASP3 protein
CTD PMID:25268046 PMID:25450235 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
JBrowse link
G Cat catalase multiple interactions EXP
ISO
galangin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased activity of CAT protein]
galangin inhibits the reaction [Benzo(a)pyrene results in decreased activity of CAT protein]
CTD PMID:33663268 PMID:35384154 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO galangin results in decreased expression of CCND1 protein CTD PMID:25450235 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO galangin results in decreased expression of CDK4 protein CTD PMID:25450235 NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163
JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO galangin results in decreased expression of CDK6 protein CTD PMID:25450235 NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:31,601,192...31,781,701
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO galangin results in increased expression of CDKN1A protein CTD PMID:25450235 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969
JBrowse link
G Cyb5a cytochrome b5 type A multiple interactions ISO galangin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYB5A protein] CTD PMID:33663268 NCBI chr18:80,487,923...80,520,544
Ensembl chr18:14,453,966...14,455,094
Ensembl chr18:14,453,966...14,455,094
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
decreases activity
ISO galangin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; galangin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]
galangin results in increased expression of CYP1A1 mRNA
galangin affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; galangin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; galangin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]
galangin results in decreased activity of CYP1A1 protein
CTD PMID:10953044 PMID:17090139 PMID:20930378 PMID:21053930 PMID:33663268 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity
ISO galangin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA]
galangin results in decreased activity of CYP1A2 protein
CTD PMID:17090139 PMID:20806393 PMID:21053930 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO galangin binds to and results in decreased activity of CYP1B1 protein
galangin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]
CTD PMID:21053930 PMID:33663268 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO galangin results in increased expression of CYP2B6 mRNA CTD PMID:25625231 NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
multiple interactions
increases activity
decreases activity
ISO galangin results in increased expression of CYP3A4 mRNA
[[galangin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [galangin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; galangin inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam]; galangin promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]
galangin results in decreased activity of CYP3A4 protein
CTD PMID:21053930 PMID:26238175 PMID:31756459 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
JBrowse link
G Egf epidermal growth factor multiple interactions ISO galangin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; galangin inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein] CTD PMID:25625231 NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:220,893,660...220,976,297
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO galangin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:25625231 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358
JBrowse link
G Elk1 ETS transcription factor ELK1 multiple interactions ISO galangin inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein] CTD PMID:25625231 NCBI chr  X:3,692,367...3,709,252
Ensembl chr  X:3,693,293...3,709,249
JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO galangin promotes the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]] CTD PMID:20153296 NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:114,946,982...115,058,574
JBrowse link
G Epas1 endothelial PAS domain protein 1 multiple interactions
increases expression
ISO ferrous sulfate inhibits the reaction [galangin results in increased expression of EPAS1 protein]; Iron inhibits the reaction [galangin results in increased expression of EPAS1 protein] CTD PMID:17973296 NCBI chr 6:13,543,252...13,626,147
Ensembl chr 6:13,544,389...13,624,729
JBrowse link
G Esr1 estrogen receptor 1 increases phosphorylation EXP galangin results in increased phosphorylation of ESR1 protein CTD PMID:17323972 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP galangin inhibits the reaction [Doxorubicin results in increased expression of GFAP protein] CTD PMID:35843304 NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685
JBrowse link
G Glo1 glyoxalase 1 multiple interactions ISO galangin results in decreased expression of and results in decreased activity of GLO1 protein CTD PMID:29113808 NCBI chr20:8,665,061...8,683,095
Ensembl chr20:8,665,061...8,683,191
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP galangin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased activity of GSR protein] CTD PMID:35384154 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases activity ISO galangin results in decreased activity of GSTP1 protein CTD PMID:15041478 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP galangin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HAVCR1 protein] CTD PMID:35384154 NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,619,897...31,653,268
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases expression
ISO ferrous sulfate inhibits the reaction [galangin results in increased expression of HIF1A protein]; galangin promotes the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]]; galangin promotes the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; Iron inhibits the reaction [galangin results in increased expression of HIF1A protein] CTD PMID:17973296 PMID:20153296 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP galangin inhibits the reaction [Doxorubicin results in increased expression of HMGB1 protein] CTD PMID:35843304 NCBI chr12:11,009,236...11,015,941
Ensembl chr16:39,039,050...39,041,327
Ensembl chr12:39,039,050...39,041,327
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP [Cadmium co-treated with galangin] results in increased expression of HMOX1 protein; galangin inhibits the reaction [Doxorubicin results in decreased expression of HMOX1 protein] CTD PMID:35384154 PMID:35843304 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818
JBrowse link
G Hrh1 histamine receptor H 1 decreases expression ISO galangin results in decreased expression of HRH1 mRNA CTD PMID:23535185 NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:149,120,039...149,208,248
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO galangin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:16987811 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
galangin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL1B mRNA]
galangin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL1B protein]; galangin inhibits the reaction [Doxorubicin results in increased expression of IL1B protein]
CTD PMID:23535185 PMID:35384154 PMID:35843304 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO
galangin inhibits the reaction [Doxorubicin results in increased expression of IL6 protein]; galangin inhibits the reaction [Fructose results in increased expression of IL6 protein]
galangin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL6 mRNA]
CTD PMID:21708140 PMID:23535185 PMID:35843304 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP galangin inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK1 protein] CTD PMID:35843304 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP galangin inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK3 protein] CTD PMID:35843304 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP galangin inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK8 protein] CTD PMID:35843304 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions EXP galangin inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK9 protein] CTD PMID:35843304 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228
JBrowse link
G Mlkl mixed lineage kinase domain like pseudokinase multiple interactions EXP galangin inhibits the reaction [Doxorubicin results in increased phosphorylation of MLKL protein] CTD PMID:35843304 NCBI chr19:56,186,860...56,213,886
Ensembl chr19:56,186,860...56,213,858
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO galangin inhibits the reaction [Benzo(a)pyrene results in increased expression of MMP2 mRNA] CTD PMID:33663268 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO galangin inhibits the reaction [Benzo(a)pyrene results in increased expression of MMP9 mRNA] CTD PMID:33663268 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO galangin results in decreased phosphorylation of MTOR protein CTD PMID:25450235 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO galangin inhibits the reaction [Benzo(a)pyrene results in increased expression of MYC mRNA] CTD PMID:33663268 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO galangin promotes the reaction [NCOA1 protein binds to NR1I2 protein]
galangin inhibits the reaction [Benzo(a)pyrene results in increased expression of NCOA1 mRNA]
CTD PMID:26238175 PMID:33663268 NCBI chr 6:32,952,090...33,229,829
Ensembl chr 6:32,952,090...33,195,924
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO galangin promotes the reaction [NCOA2 protein binds to NR1I2 protein] CTD PMID:26238175 NCBI chr 5:10,618,712...10,852,776
Ensembl chr 5:10,618,722...10,852,776
JBrowse link
G Ncoa3 nuclear receptor coactivator 3 multiple interactions ISO galangin promotes the reaction [NCOA3 protein binds to NR1I2 protein] CTD PMID:26238175 NCBI chr 3:175,157,824...175,237,831
Ensembl chr 3:175,157,821...175,240,631
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases expression
multiple interactions
ISO
EXP
galangin results in decreased expression of NFE2L2 protein
[Cadmium co-treated with galangin] results in increased expression of NFE2L2 protein; galangin inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]
CTD PMID:29113808 PMID:35384154 PMID:35843304 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO galangin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased degradation of NFKBIA protein] CTD PMID:23535185 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP galangin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NLRP3 protein] CTD PMID:35384154 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP
ISO
galangin inhibits the reaction [Doxorubicin results in increased expression of NOS2 protein]
galangin inhibits the reaction [Benzo(a)pyrene results in increased expression of NOS2 mRNA]
CTD PMID:33663268 PMID:35843304 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions EXP galangin inhibits the reaction [Doxorubicin results in increased expression of NOX1 protein] CTD PMID:35843304 NCBI chr  X:101,572,338...101,625,571
Ensembl chr  X:101,572,340...101,595,520
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP
ISO
[Cadmium co-treated with galangin] results in increased expression of NQO1 protein
galangin inhibits the reaction [Benzo(a)pyrene results in increased expression of NQO1 mRNA]
CTD PMID:33663268 PMID:35384154 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
ISO galangin binds to and results in increased activity of NR1I2 protein; galangin promotes the reaction [NCOA1 protein binds to NR1I2 protein]; galangin promotes the reaction [NCOA2 protein binds to NR1I2 protein]; galangin promotes the reaction [NCOA3 protein binds to NR1I2 protein]
galangin results in increased activity of NR1I2 protein
CTD PMID:26238175 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects localization
increases expression
ISO galangin affects the localization of NR1I3 protein
galangin results in increased expression of NR1I3 mRNA
CTD PMID:25625231 NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO galangin results in increased cleavage of PARP1 protein CTD PMID:18455702 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567
JBrowse link
G Pycard PYD and CARD domain containing multiple interactions EXP galangin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PYCARD protein] CTD PMID:35384154 NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:192,032,124...192,033,419
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO galangin results in decreased phosphorylation of RB1 protein CTD PMID:25450235 NCBI chr15:54,780,858...54,911,989
Ensembl chr15:54,780,858...54,911,857
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO
galangin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which affects the localization of RELA protein]; galangin inhibits the reaction [Doxorubicin results in increased expression of RELA protein modified form]; galangin inhibits the reaction [Fructose affects the localization of RELA protein]
galangin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] affects the localization of RELA protein]
CTD PMID:21708140 PMID:23535185 PMID:35384154 PMID:35843304 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 multiple interactions EXP galangin inhibits the reaction [Doxorubicin results in increased phosphorylation of RIPK1 protein] CTD PMID:35843304 NCBI chr17:31,044,983...31,077,167
Ensembl chr17:31,044,994...31,077,167
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 multiple interactions EXP galangin inhibits the reaction [Doxorubicin results in increased phosphorylation of RIPK3 protein] CTD PMID:35843304 NCBI chr15:33,253,071...33,262,025
Ensembl chr15:33,253,071...33,262,025
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO galangin results in decreased phosphorylation of RPS6KB1 protein CTD PMID:25450235 NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,815,614...71,865,238
JBrowse link
G Sele selectin E multiple interactions ISO galangin inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:16987811 NCBI chr13:78,935,997...78,945,905
Ensembl chr13:78,936,036...78,945,903
JBrowse link
G Smad1 SMAD family member 1 increases expression
multiple interactions
increases phosphorylation
ISO galangin results in increased expression of SMAD1 mRNA
LY2109761 inhibits the reaction [galangin results in increased phosphorylation of SMAD1 protein]
CTD PMID:25268046 NCBI chr19:45,417,430...45,477,962
Ensembl chr19:45,417,433...45,477,957
JBrowse link
G Smad2 SMAD family member 2 increases expression
multiple interactions
increases phosphorylation
ISO galangin results in increased expression of SMAD2 mRNA
LY2109761 inhibits the reaction [galangin results in increased phosphorylation of SMAD2 protein]
CTD PMID:25268046 NCBI chr18:72,124,792...72,193,345
Ensembl chr18:72,124,863...72,187,388
JBrowse link
G Smad3 SMAD family member 3 increases expression
multiple interactions
increases phosphorylation
ISO galangin results in increased expression of SMAD3 mRNA
LY2109761 inhibits the reaction [galangin results in increased phosphorylation of SMAD3 protein]
CTD PMID:25268046 NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:73,024,760...73,132,324
JBrowse link
G Smad4 SMAD family member 4 multiple interactions
increases expression
ISO SMAD4 mutant form inhibits the reaction [galangin results in increased expression of ATG12 protein]; SMAD4 mutant form inhibits the reaction [galangin results in increased expression of ATG16L1 protein]; SMAD4 mutant form inhibits the reaction [galangin results in increased expression of ATG3 protein]; SMAD4 mutant form inhibits the reaction [galangin results in increased expression of BECN1 protein]
galangin results in increased expression of SMAD4 mRNA
CTD PMID:25268046 NCBI chr18:69,518,988...69,549,684
Ensembl chr18:69,518,988...69,549,684
JBrowse link
G Smad6 SMAD family member 6 decreases expression ISO galangin results in decreased expression of SMAD6 mRNA CTD PMID:25268046 NCBI chr 8:73,345,457...73,414,985
Ensembl chr 8:73,345,460...73,414,149
JBrowse link
G Smad7 SMAD family member 7 decreases expression ISO galangin results in decreased expression of SMAD7 mRNA CTD PMID:25268046 NCBI chr18:71,263,508...71,291,849
Ensembl chr18:71,263,508...71,291,849
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO galangin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of STAT3 protein] CTD PMID:20153296 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP
ISO
galangin inhibits the reaction [Fructose results in increased expression of TGFB1 protein]
galangin inhibits the reaction [Benzo(a)pyrene results in increased expression of TGFB1 mRNA]
CTD PMID:21708140 PMID:33663268 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 increases expression ISO galangin results in increased expression of TGFBR1 mRNA CTD PMID:25268046 NCBI chr 5:66,449,348...66,506,371
Ensembl chr 5:66,449,293...66,527,260
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 increases expression ISO galangin results in increased expression of TGFBR2 mRNA CTD PMID:25268046 NCBI chr 8:124,672,677...124,761,741
Ensembl chr 8:124,674,986...124,761,469
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP galangin inhibits the reaction [Doxorubicin results in increased expression of TLR4 protein] CTD PMID:35843304 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
galangin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TNF protein]; galangin inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; galangin inhibits the reaction [Fructose results in increased expression of TNF mRNA]; galangin inhibits the reaction [Fructose results in increased expression of TNF protein]
galangin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNF mRNA]; galangin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; galangin inhibits the reaction [TNF protein results in increased expression of SELE protein]
CTD PMID:16987811 PMID:21708140 PMID:23535185 PMID:35384154 PMID:35843304 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
G Tyr tyrosinase increases expression ISO galangin results in increased expression of TYR mRNA CTD PMID:21071833 NCBI chr 1:150,527,687...150,622,857
Ensembl chr 1:150,527,687...150,622,857
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of galangin CTD PMID:14557274 NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 decreases activity ISO galangin results in decreased activity of UGT1A3 protein CTD PMID:35063619 NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:96,144,786...96,256,264
JBrowse link
G Ugt1a6a UDP glucuronosyltransferase family 1 member A6a decreases activity ISO galangin results in decreased activity of UGT1A6 protein CTD PMID:35063619 NCBI chr 9:96,195,018...96,256,264
Ensembl chr 9:96,144,786...96,256,264
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation
decreases activity
ISO UGT1A9 protein results in increased glucuronidation of galangin
galangin results in decreased activity of UGT1A9 protein
CTD PMID:14557274 PMID:35063619 NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 decreases activity ISO galangin results in decreased activity of UGT2B7 protein CTD PMID:35063619 NCBI chr14:21,251,535...21,274,451
Ensembl chr14:21,251,535...21,274,451
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO galangin promotes the reaction [Oxygen deficiency results in increased expression of and results in increased localization of VEGFA protein] CTD PMID:20153296 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194
JBrowse link
orlistat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd12 abhydrolase domain containing 12, lysophospholipase decreases activity ISO orlistat results in decreased activity of ABHD12 protein CTD PMID:18657971 NCBI chr 3:160,119,724...160,179,959
Ensembl chr 3:160,119,724...160,179,969
JBrowse link
G Abhd16a abhydrolase domain containing 16A, phospholipase decreases activity ISO orlistat results in decreased activity of ABHD16A protein CTD PMID:18657971 NCBI chr20:3,723,756...3,738,617
Ensembl chr20:3,723,757...3,738,736
JBrowse link
G Acaca acetyl-CoA carboxylase alpha multiple interactions
decreases expression
ISO Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ACACA mRNA]
Orlistat results in decreased expression of ACACA mRNA
CTD PMID:32347045 PMID:33476690 NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,511,857...69,773,888
JBrowse link
G Ache acetylcholinesterase decreases activity ISO Orlistat results in decreased activity of ACHE protein CTD PMID:33844597 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410
JBrowse link
G Acot8 acyl-CoA thioesterase 8 decreases expression ISO Orlistat results in decreased expression of ACOT8 protein CTD PMID:30667213 NCBI chr 3:173,950,530...173,962,188
Ensembl chr 3:173,950,531...173,962,570
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions EXP
ISO
orlistat inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ protein]
Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ADIPOQ protein]
CTD PMID:25087745 PMID:33476690 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in decreased expression of PTEN protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased abundance of Malondialdehyde]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased abundance of Triglycerides]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of CCND1 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of CD34 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of FASN protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of IL6 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of PCNA protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of PTGS2 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of SREBF1 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of TNF protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased phosphorylation of MAPK1 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased phosphorylation of MAPK3 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased phosphorylation of RPS6 protein] CTD PMID:32045588 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO [1,1,1,2,2-pentafluoro-7-phenylheptan-3-one co-treated with Orlistat] inhibits the reaction [APP protein modified form results in increased secretion of Arachidonic Acid] CTD PMID:28721267 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971
JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO orlistat results in increased expression of ATF4 mRNA CTD PMID:17283163 NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Orlistat inhibits the reaction [Dietary Fats results in increased expression of BAX mRNA] CTD PMID:32450208 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Orlistat inhibits the reaction [Dietary Fats results in decreased expression of BCL2 mRNA] CTD PMID:32450208 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage
multiple interactions
ISO
EXP
orlistat results in increased activity of CASP3 protein
orlistat results in increased cleavage of CASP3 protein
Orlistat inhibits the reaction [Dietary Fats results in increased expression of CASP3 mRNA]
CTD PMID:17283163 PMID:20805790 PMID:21723078 PMID:32450208 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
JBrowse link
G Casp8 caspase 8 multiple interactions ISO
EXP
orlistat analog results in increased cleavage of and results in increased activity of CASP8 protein; orlistat results in increased cleavage of and results in increased activity of CASP8 protein
Orlistat inhibits the reaction [Dietary Fats results in increased expression of CASP8 mRNA]
CTD PMID:18796435 PMID:20577697 PMID:32450208 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699
JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
ISO
EXP
orlistat results in increased activity of CASP9 protein
Orlistat inhibits the reaction [Dietary Fats results in increased expression of CASP9 mRNA]
CTD PMID:20805790 PMID:32450208 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase multiple interactions
decreases expression
EXP
ISO
Orlistat inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]; Orlistat inhibits the reaction [Dietary Fats results in decreased expression of CAT mRNA]; Orlistat inhibits the reaction [Dietary Fats results in decreased expression of CAT protein]
Orlistat results in decreased expression of CAT protein
CTD PMID:25087745 PMID:30667213 PMID:32450208 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
JBrowse link
G Cck cholecystokinin multiple interactions
decreases secretion
ISO [[orlistat results in decreased abundance of Fatty Acids, Nonesterified] which results in decreased secretion of CCK protein] which results in decreased secretion of PNLIP protein; orlistat inhibits the reaction [Fats results in increased secretion of CCK protein]; orlistat inhibits the reaction [Olive Oil results in increased secretion of CCK protein]
orlistat results in decreased secretion of CCK protein
CTD PMID:11408251 PMID:18303078 PMID:18647814 NCBI chr 8:130,031,012...130,037,702
Ensembl chr 8:130,031,013...130,037,686
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO Orlistat results in decreased expression of CCNA2 protein CTD PMID:30667213 NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:121,355,363...121,361,701
JBrowse link
G Ccnd1 cyclin D1 increases expression
multiple interactions
ISO Orlistat results in increased expression of CCND1 protein
Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of CCND1 protein]
CTD PMID:30667213 PMID:32045588 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810
JBrowse link
G Ccne1 cyclin E1 increases expression ISO Orlistat results in increased expression of CCNE1 protein CTD PMID:30667213 NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:99,918,674...99,927,822
JBrowse link
G Cd34 CD34 molecule multiple interactions ISO Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of CD34 protein] CTD PMID:32045588 NCBI chr13:109,008,786...109,029,317
Ensembl chr13:109,008,623...109,029,315
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO Orlistat results in decreased expression of CDK1 protein CTD PMID:30667213 NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO Orlistat results in decreased expression of CDK2 protein CTD PMID:30667213 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO Orlistat results in decreased expression of CDK4 protein CTD PMID:30667213 NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Orlistat results in increased expression of CDKN1A protein CTD PMID:30667213 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO orlistat results in increased expression of CDKN1B protein CTD PMID:15138278 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO Orlistat promotes the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of CEBPA protein] CTD PMID:33476690 NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:96,896,171...96,899,309
JBrowse link
G Cel carboxyl ester lipase decreases activity ISO orlistat results in decreased activity of CEL protein CTD PMID:11592731 PMID:12381337 NCBI chr 3:32,281,518...32,289,019
Ensembl chr 3:32,281,518...32,289,019
JBrowse link
G Clps colipase multiple interactions ISO orlistat inhibits the reaction [[PNLIP protein co-treated with CLPS protein] results in increased hydrolysis of Olive Oil] CTD PMID:15158758 NCBI chr20:6,622,234...6,624,414
Ensembl chr20:6,622,231...6,624,505
JBrowse link
G Cpb2 carboxypeptidase B2 decreases expression ISO orlistat results in decreased expression of CPB2 protein CTD PMID:16959692 NCBI chr15:56,967,128...57,015,964
Ensembl chr15:56,966,839...57,015,962
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression ISO Orlistat results in decreased expression of CPT1A protein CTD PMID:30667213 NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:209,993,875...210,056,326
JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 decreases expression ISO Orlistat results in decreased expression of CPT2 protein CTD PMID:30667213 NCBI chr 5:127,893,450...127,911,347
Ensembl chr 5:127,893,207...127,910,818
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO Orlistat results in increased expression of CYP3A4 mRNA; Orlistat results in increased expression of CYP3A4 protein CTD PMID:20599501 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
JBrowse link
G Dagla diacylglycerol lipase, alpha decreases activity ISO orlistat results in decreased activity of DAGLA protein CTD PMID:16466961 NCBI chr 1:216,315,515...216,372,219
Ensembl chr 1:216,315,516...216,372,111
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO orlistat results in increased expression of DDIT3 mRNA CTD PMID:17283163 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO orlistat results in increased expression of DDIT4 mRNA CTD PMID:18796435 NCBI chr20:28,434,938...28,437,037
Ensembl chr20:28,434,944...28,437,037
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases phosphorylation
multiple interactions
ISO orlistat results in increased phosphorylation of EIF2A protein
orlistat analog results in increased phosphorylation of EIF2A protein; orlistat results in increased phosphorylation of EIF2A protein
Cycloheximide inhibits the reaction [orlistat results in increased phosphorylation of EIF2A protein]
orlistat promotes the reaction [EIF2AK3 protein results in increased phosphorylation of EIF2A protein]
CTD PMID:17283163 PMID:20577697 NCBI chr 2:144,911,247...144,944,705
Ensembl chr 2:144,911,153...144,945,201
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases response to substance
multiple interactions
ISO EIF2AK3 gene mutant form results in increased susceptibility to orlistat
orlistat promotes the reaction [EIF2AK3 protein results in increased phosphorylation of EIF2A protein]
CTD PMID:17283163 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E increases phosphorylation ISO orlistat results in increased phosphorylation of EIF4E protein CTD PMID:18796435 NCBI chr 2:229,736,309...229,772,628
Ensembl chr 2:229,739,897...229,774,105
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 affects response to substance
decreases expression
affects localization
ISO ERBB2 protein affects the susceptibility to orlistat
orlistat results in decreased expression of ERBB2 mRNA; orlistat results in decreased expression of ERBB2 protein
orlistat affects the localization of ERBB2 protein
CTD PMID:15870086 NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,907,460...83,931,481
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO orlistat affects the reaction [ERN1 protein affects the splicing of XBP1 mRNA] CTD PMID:17283163 NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,830,428...91,920,791
JBrowse link
G Etv4 ETS variant transcription factor 4 increases expression ISO orlistat results in increased expression of ETV4 protein CTD PMID:15870086 NCBI chr10:87,206,977...87,222,202
Ensembl chr10:87,206,977...87,222,318
JBrowse link
G Fabp1 fatty acid binding protein 1 decreases expression ISO Orlistat results in decreased expression of FABP1 protein CTD PMID:30667213 NCBI chr 4:104,744,302...104,753,119
Ensembl chr 4:104,744,309...104,753,113
JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO Orlistat results in decreased expression of FAS mRNA CTD PMID:32347045 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104
JBrowse link
G Fasn fatty acid synthase affects binding
affects response to substance
multiple interactions
decreases activity
decreases expression
ISO orlistat analog binds to FASN protein
FASN protein affects the susceptibility to orlistat
[Orlistat results in decreased activity of FASN protein] which results in decreased abundance of Fatty Acids; [Orlistat results in decreased activity of FASN protein] which results in decreased abundance of Phosphatidylcholines; [Orlistat results in decreased activity of FASN protein] which results in decreased abundance of Phosphorylcholine; [Orlistat results in decreased activity of FASN protein] which results in decreased chemical synthesis of Fatty Acids; [Orlistat results in decreased activity of FASN protein] which results in decreased expression of SKP2 protein; Orlistat binds to and results in decreased activity of FASN protein; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of FASN protein]; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of FASN mRNA]; Orlistat inhibits the reaction [FASN protein results in decreased susceptibility to Doxorubicin]; Orlistat inhibits the reaction [FASN protein results in decreased susceptibility to Mitoxantrone]
orlistat analog results in decreased activity of FASN protein; orlistat results in decreased activity of FASN protein
[orlistat results in decreased activity of FASN protein] which affects the abundance of Fatty Acids, Nonesterified; orlistat inhibits the reaction [FASN protein results in increased chemical synthesis of Palmitic Acid]
Orlistat results in decreased expression of FASN protein
CTD PMID:15026345 PMID:15138278 PMID:15870086 PMID:17012255 PMID:17618296 More... NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583
JBrowse link
G Gcg glucagon multiple interactions
decreases expression
decreases secretion
ISO orlistat inhibits the reaction [Dietary Fats results in increased secretion of GCG protein]; orlistat inhibits the reaction [Olive Oil results in increased secretion of GCG protein]
orlistat results in decreased expression of GCG protein
orlistat results in decreased secretion of GCG protein
CTD PMID:12915676 PMID:18647814 PMID:19837920 NCBI chr 3:67,522,489...67,531,533
Ensembl chr 3:67,522,489...67,531,533
JBrowse link
G Ghrl ghrelin and obestatin prepropeptide multiple interactions ISO orlistat inhibits the reaction [Olive Oil results in decreased expression of GHRL protein]; orlistat inhibits the reaction [Triglycerides results in decreased secretion of GHRL protein] CTD PMID:15998659 PMID:17138722 NCBI chr 4:148,421,315...148,431,128
Ensembl chr 4:148,421,315...148,425,969
JBrowse link
G Gip gastric inhibitory polypeptide decreases expression ISO orlistat results in decreased expression of GIP protein CTD PMID:12915676 NCBI chr10:81,465,070...81,473,216
Ensembl chr10:81,465,062...81,473,216
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP orlistat inhibits the reaction [[Corn Oil co-treated with (5'-(4-amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido(4,5-b)(1,4)oxazin-6-yl)-2',3'-dihydrospiro(cyclohexane-1,1'-inden)-4-yl)acetic acid] results in increased activity of GPT protein] CTD PMID:29479035 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions EXP Orlistat inhibits the reaction [Dietary Fats results in decreased expression of GPX1 mRNA] CTD PMID:32450208 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581
JBrowse link
G Gpx8 glutathione peroxidase 8 increases expression ISO orlistat results in increased expression of GPX8 mRNA CTD PMID:18796435 NCBI chr 2:46,409,646...46,413,401
Ensembl chr 2:46,409,139...46,413,406
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP Orlistat inhibits the reaction [Dietary Fats results in decreased expression of GSR protein] CTD PMID:32450208 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394
JBrowse link
G Hba-a2 hemoglobin alpha, adult chain 2 decreases expression ISO orlistat results in decreased expression of HBA1 protein modified form CTD PMID:19207292 PMID:19461584 NCBI chr10:15,828,291...15,829,138
Ensembl chr10:15,828,377...15,829,141
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP orlistat inhibits the reaction [Dietary Fats results in increased expression of HMGCR protein] CTD PMID:25087745 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO orlistat results in increased expression of HSPA5 mRNA CTD PMID:17283163 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790
JBrowse link
G Il10 interleukin 10 increases expression EXP Orlistat results in increased expression of IL10 mRNA CTD PMID:32450208 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Orlistat inhibits the reaction [Dietary Fats results in increased expression of IL1B mRNA] CTD PMID:32450208 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of IL6 protein]; Orlistat inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]
Orlistat inhibits the reaction [Dietary Fats results in increased expression of IL6 protein]
CTD PMID:21088047 PMID:32045588 PMID:32735172 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
JBrowse link
G Ins1 insulin 1 multiple interactions EXP Orlistat inhibits the reaction [Dietary Fats results in increased expression of INS1 protein] CTD PMID:25087745 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682
JBrowse link
G Ins2 insulin 2 decreases expression
increases expression
affects expression
multiple interactions
ISO orlistat results in decreased expression of INS protein
orlistat results in increased expression of INS protein
orlistat affects the expression of INS protein
[Orlistat co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of NFE2L2 mRNA; [Orlistat co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of TGFB1 mRNA; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ACACA mRNA]; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ADIPOQ protein]; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of FASN mRNA]; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARD mRNA]; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of UCP1 mRNA]; Orlistat promotes the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of CEBPA protein]
CTD PMID:10095983 PMID:11274935 PMID:12915676 PMID:33476690 NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805
JBrowse link
G Kdelr3 KDEL endoplasmic reticulum protein retention receptor 3 increases expression ISO orlistat results in increased expression of KDELR3 mRNA CTD PMID:18796435 NCBI chr 7:112,959,632...112,969,858
Ensembl chr 7:112,959,718...112,969,858
JBrowse link
G Kdr kinase insert domain receptor decreases expression ISO orlistat results in decreased expression of KDR protein CTD PMID:17012255 NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,572,049...32,615,192
JBrowse link
G Krt81 keratin 81 increases expression ISO orlistat results in increased expression of KRT81 mRNA CTD PMID:18796435 NCBI chr 7:134,455,840...134,460,971
Ensembl chr 7:134,455,842...134,460,967
JBrowse link
G Lcat lecithin cholesterol acyltransferase multiple interactions EXP orlistat inhibits the reaction [Dietary Fats results in decreased expression of LCAT protein] CTD PMID:25087745 NCBI chr19:50,744,598...50,748,064
Ensembl chr19:50,744,601...50,748,081
JBrowse link
G Lep leptin multiple interactions ISO
EXP
orlistat inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:21332399 PMID:25087745 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661
JBrowse link
G Lipf lipase F, gastric type decreases activity ISO orlistat results in decreased activity of LIPF protein CTD PMID:11408251 PMID:12381337 NCBI chr 1:240,906,706...240,925,053
Ensembl chr 1:240,906,706...240,925,053
JBrowse link
G Lpl lipoprotein lipase decreases activity
multiple interactions
ISO
EXP
orlistat results in decreased activity of LPL protein
orlistat inhibits the reaction [Dietary Fats results in decreased expression of LPL protein]
orlistat inhibits the reaction [[LPL protein results in increased hydrolysis of Triglycerides] which results in increased uptake of Triglycerides]; orlistat inhibits the reaction [LPL protein results in decreased activity of TNF protein]; orlistat inhibits the reaction [very low density lipoprotein triglyceride results in increased activity of LPL protein]
[orlistat results in decreased activity of LPL protein] which affects the uptake of Triglycerides
CTD PMID:12388125 PMID:12573449 PMID:15910848 PMID:15994321 PMID:18698144 More... NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased phosphorylation of MAPK1 protein] CTD PMID:32045588 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased phosphorylation of MAPK3 protein] CTD PMID:32045588 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase multiple interactions ISO Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in decreased expression of PTEN protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased abundance of Malondialdehyde]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased abundance of Triglycerides]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of CCND1 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of CD34 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of FASN protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of IL6 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of PCNA protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of PTGS2 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of SREBF1 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of TNF protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased phosphorylation of MAPK1 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased phosphorylation of MAPK3 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased phosphorylation of RPS6 protein] CTD PMID:32045588 NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:46,756,506...46,870,821
JBrowse link
G Napepld N-acyl phosphatidylethanolamine phospholipase D decreases activity EXP orlistat results in decreased activity of NAPEPLD protein CTD PMID:16466961 NCBI chr 4:14,251,591...14,291,010
Ensembl chr 4:14,252,692...14,291,014
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP
ISO
Orlistat inhibits the reaction [Dietary Fats results in decreased expression of NFE2L2 mRNA]
[Orlistat co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of NFE2L2 mRNA
CTD PMID:32450208 PMID:33476690 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Orlistat inhibits the reaction [Dietary Fats results in increased expression of NOS2 mRNA]; Orlistat inhibits the reaction [Dietary Fats results in increased expression of NOS2 protein] CTD PMID:32450208 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
JBrowse link
G Npy neuropeptide Y increases expression ISO orlistat results in increased expression of NPY protein CTD PMID:15962606 NCBI chr 4:80,212,111...80,219,310
Ensembl chr 4:80,212,111...80,219,310
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO orlistat results in increased activity of NR1I2 protein CTD PMID:20599501 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO Orlistat binds to and results in increased activity of NR1I3 protein alternative form CTD PMID:31312845 NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370
JBrowse link
G Nts neurotensin multiple interactions ISO Orlistat inhibits the reaction [Fats results in increased secretion of NTS protein]; Orlistat inhibits the reaction [Olive Oil results in increased secretion of NTS protein] CTD PMID:18303078 NCBI chr 7:39,451,484...39,460,888
Ensembl chr 7:39,451,073...39,460,961
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO [orlistat co-treated with Thapsigargin] results in increased cleavage of PARP1 protein
orlistat results in increased cleavage of PARP1 protein
CTD PMID:15870086 PMID:17283163 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of PCNA protein] CTD PMID:32045588 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901
JBrowse link
G Pla2g7 phospholipase A2 group VII decreases activity
multiple interactions
ISO orlistat results in decreased activity of PLA2G7 protein
[orlistat co-treated with Ezetimibe] results in decreased activity of PLA2G7 protein; [orlistat co-treated with Fenofibrate] results in decreased activity of PLA2G7 protein
CTD PMID:16911813 PMID:18513463 PMID:18657971 NCBI chr 9:24,859,491...24,901,747
Ensembl chr 9:24,859,502...24,901,747
JBrowse link
G Pnlip pancreatic lipase decreases secretion
decreases activity
multiple interactions
affects folding
ISO
EXP
orlistat results in decreased secretion of PNLIP protein
orlistat results in decreased activity of PNLIP protein
orlistat inhibits the reaction [Taurocholic Acid results in increased activity of PNLIP protein]
orlistat affects the folding of PNLIP protein
[[orlistat results in decreased abundance of Fatty Acids, Nonesterified] which results in decreased secretion of CCK protein] which results in decreased secretion of PNLIP protein; orlistat inhibits the reaction [[PNLIP protein co-treated with CLPS protein] results in increased hydrolysis of Olive Oil]
CTD PMID:11408251 PMID:11668201 PMID:12381337 PMID:15158758 PMID:19346257 NCBI chr 1:267,760,073...267,797,797
Ensembl chr 1:267,784,724...267,797,795
JBrowse link
G Pnliprp2 pancreatic lipase related protein 2 decreases activity ISO
EXP
orlistat results in decreased activity of PNLIPRP2 protein
Orlistat results in decreased activity of PNLIPRP2 protein
CTD PMID:9822688 PMID:17401110 NCBI chr 1:267,883,906...267,902,572
Ensembl chr 1:267,883,906...267,902,572
JBrowse link
G Pon1 paraoxonase 1 increases activity ISO orlistat results in increased activity of PON1 protein CTD PMID:11820148 PMID:17134960 NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:34,261,289...34,287,924
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta multiple interactions ISO Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARD mRNA] CTD PMID:33476690 NCBI chr20:6,300,527...6,365,707
Ensembl chr20:6,352,183...6,365,707
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression ISO Orlistat results in increased expression of PPARG mRNA CTD PMID:32347045 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104
JBrowse link
G Ppt1 palmitoyl-protein thioesterase 1 decreases expression ISO Orlistat results in decreased expression of PPT1 protein CTD PMID:30667213 NCBI chr 5:140,406,318...140,427,201
Ensembl chr 5:140,406,214...140,427,200
JBrowse link
G Ppy pancreatic polypeptide multiple interactions ISO orlistat inhibits the reaction [Triglycerides results in increased secretion of PPY protein] CTD PMID:15998659 NCBI chr10:87,554,941...87,556,236
Ensembl chr10:87,554,950...87,556,719
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions EXP
ISO
orlistat inhibits the reaction [Isoproterenol results in increased phosphorylation of PRKAA1 protein]
orlistat inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased phosphorylation of and results in increased activity of PRKAA1 protein]; orlistat inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of PRKAA1 protein]
CTD PMID:18390901 PMID:19167487 NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:55,967,351...56,003,450
JBrowse link
G Pten phosphatase and tensin homolog increases expression
multiple interactions
ISO Orlistat results in increased expression of PTEN protein
Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in decreased expression of PTEN protein]
CTD PMID:32045588 NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of PTGS2 protein] CTD PMID:32045588 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
JBrowse link
G Pyy peptide YY decreases secretion
multiple interactions
ISO orlistat results in decreased secretion of PYY protein
orlistat inhibits the reaction [Olive Oil results in increased expression of PYY protein]; orlistat inhibits the reaction [Triglycerides results in increased secretion of PYY protein]
CTD PMID:15998659 PMID:17138722 PMID:18647814 NCBI chr10:87,561,347...87,562,470
Ensembl chr10:87,561,353...87,562,206
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO orlistat results in decreased phosphorylation of RB1 protein CTD PMID:15138278 NCBI chr15:54,780,858...54,911,989
Ensembl chr15:54,780,858...54,911,857
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Orlistat inhibits the reaction [Dietary Fats results in increased expression of RELA mRNA] CTD PMID:32450208 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
JBrowse link
G Rps6 ribosomal protein S6 multiple interactions ISO Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased phosphorylation of RPS6 protein] CTD PMID:32045588 NCBI chr 5:106,417,680...106,420,540
Ensembl chr 5:106,417,680...106,420,566
JBrowse link
G Sec24d SEC24 homolog D, COPII coat complex component increases expression ISO orlistat results in increased expression of SEC24D mRNA CTD PMID:18796435 NCBI chr 2:214,103,138...214,211,155
Ensembl chr 2:214,103,190...214,211,144
JBrowse link
G Skp2 S-phase kinase associated protein 2 multiple interactions
decreases expression
ISO [orlistat results in decreased activity of FASN protein] which results in decreased expression of SKP2 protein
orlistat results in decreased expression of SKP2 protein
CTD PMID:15138278 NCBI chr 2:59,888,406...59,916,471
Ensembl chr 2:59,888,413...59,916,438
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO orlistat inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions
decreases expression
ISO Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of SREBF1 protein]
Orlistat results in decreased expression of SREBF1 protein
CTD PMID:32045588 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164
JBrowse link
G Tf transferrin multiple interactions ISO [Orlistat co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of NFE2L2 mRNA; [Orlistat co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of TGFB1 mRNA; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ACACA mRNA]; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ADIPOQ protein]; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of FASN mRNA]; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARD mRNA]; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of UCP1 mRNA]; Orlistat promotes the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of CEBPA protein] CTD PMID:33476690 NCBI chr 8:112,668,667...112,695,376
Ensembl chr 8:112,647,642...112,695,400
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [Orlistat co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of TGFB1 mRNA CTD PMID:33476690 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Orlistat inhibits the reaction [Dietary Fats results in increased expression of TLR4 protein] CTD PMID:32735172 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of TNF protein]; Orlistat inhibits the reaction [LPL protein results in decreased activity of TNF protein]
Orlistat inhibits the reaction [Dietary Fats results in increased expression of TNF mRNA]
Orlistat inhibits the reaction [Dietary Fats results in increased expression of TNF protein]
CTD PMID:15994321 PMID:32045588 PMID:32450208 PMID:32735172 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
G Tnfsf10 TNF superfamily member 10 increases response to substance ISO orlistat results in increased susceptibility to TNFSF10 protein CTD PMID:18796435 PMID:21406729 NCBI chr 2:112,136,550...112,155,903 JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP Orlistat inhibits the reaction [Dietary Fats results in increased expression of TP53 mRNA] CTD PMID:32450208 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299
JBrowse link
G Ucp1 uncoupling protein 1 multiple interactions ISO Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of UCP1 mRNA] CTD PMID:33476690 NCBI chr19:41,713,350...41,721,421
Ensembl chr19:41,713,351...41,721,420
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO orlistat affects the reaction [ERN1 protein affects the splicing of XBP1 mRNA] CTD PMID:17283163 NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706
JBrowse link
sodium benzoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
increases expression
increases activity
EXP
ISO
Ascorbic Acid inhibits the reaction [Sodium Benzoate results in increased activity of ACHE protein]; Coconut Oil affects the reaction [Sodium Benzoate results in increased expression of ACHE mRNA]
Sodium Benzoate results in increased expression of ACHE protein
CTD PMID:30154464 PMID:35187746 PMID:36265761 PMID:38243570 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO Sodium Benzoate inhibits the reaction [arsenite results in increased expression of ACTA2 protein] CTD PMID:38703806 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503
JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 multiple interactions ISO Sodium Benzoate inhibits the reaction [Adenine results in increased expression of ADGRE1 mRNA] CTD PMID:36849798 NCBI chr 9:2,329,398...2,484,959
Ensembl chr 9:2,329,438...2,484,959
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO Sodium Benzoate inhibits the reaction [[DAO protein results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA] CTD PMID:19860415 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901
JBrowse link
G Aif1 allograft inflammatory factor 1 multiple interactions ISO Sodium Benzoate inhibits the reaction [Adenine results in increased expression of AIF1 mRNA] CTD PMID:36849798 NCBI chr20:3,651,435...3,657,341
Ensembl chr20:3,652,243...3,657,339
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated decreases expression EXP Sodium Benzoate results in decreased expression of ALPL protein CTD PMID:37045926 NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167
JBrowse link
G Ar androgen receptor decreases expression
multiple interactions
EXP Sodium Benzoate results in decreased expression of AR mRNA
[Zinc Sulfate results in increased abundance of Zinc] inhibits the reaction [Sodium Benzoate results in decreased expression of AR mRNA]
CTD PMID:39106537 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:67,135,317...67,304,467
JBrowse link
G Atf2 activating transcription factor 2 multiple interactions ISO Sodium Benzoate inhibits the reaction [amyloid beta-protein (1-42) results in increased expression of ATF2 protein] CTD PMID:32781134 NCBI chr 3:79,125,814...79,202,896
Ensembl chr 3:79,126,705...79,202,745
JBrowse link
G Bcl2l11 Bcl2-like 11 increases expression
multiple interactions
ISO Sodium Benzoate results in increased expression of BCL2L11 protein
3-(4-methylphenylsulfonyl)-2-propenenitrile affects the reaction [Sodium Benzoate results in increased expression of BCL2L11 protein]
CTD PMID:29565269 NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:135,817,562...135,960,695
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions EXP Sodium Benzoate promotes the reaction [Cocaine results in increased phosphorylation of and results in increased activity of CAMK2A protein] CTD PMID:17609678 NCBI chr18:56,648,779...56,711,505
Ensembl chr18:56,649,025...56,711,504
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases expression
ISO
EXP
3-(4-methylphenylsulfonyl)-2-propenenitrile affects the reaction [Sodium Benzoate results in increased activity of CASP3 protein]; Sodium Benzoate inhibits the reaction [Asbestos, Amosite results in increased activity of CASP3 protein]
Sodium Benzoate results in increased expression of CASP3 protein
[Zinc Sulfate results in increased abundance of Zinc] inhibits the reaction [Sodium Benzoate results in increased expression of CASP3 protein]; Ascorbic Acid inhibits the reaction [Sodium Benzoate results in increased expression of CASP3 protein]
CTD PMID:11329530 PMID:29565269 PMID:32911041 PMID:35187746 PMID:39106537 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Sodium Benzoate inhibits the reaction [Asbestos, Amosite results in increased activity of CASP9 protein] CTD PMID:12540492 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase decreases activity
decreases expression
multiple interactions
EXP Sodium Benzoate results in decreased activity of CAT protein
Sodium Benzoate results in decreased expression of CAT protein
[Zinc Sulfate results in increased abundance of Zinc] inhibits the reaction [Sodium Benzoate results in decreased activity of CAT protein]; [Zinc Sulfate results in increased abundance of Zinc] inhibits the reaction [Sodium Benzoate results in decreased expression of CAT protein]; Ascorbic Acid inhibits the reaction [Sodium Benzoate results in decreased activity of CAT protein]; Coconut Oil inhibits the reaction [Sodium Benzoate results in decreased expression of CAT protein]
CTD PMID:32911041 PMID:35187746 PMID:36265761 PMID:37045926 PMID:38243570 More... NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Sodium Benzoate inhibits the reaction [Adenine results in increased expression of CCL2 mRNA]
Sodium Benzoate inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; Sodium Benzoate inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]
CTD PMID:36849798 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875
JBrowse link
G Cd163 CD163 molecule multiple interactions ISO Sodium Benzoate inhibits the reaction [Adenine results in increased expression of CD163 mRNA] CTD PMID:36849798 NCBI chr 4:158,770,751...158,804,146
Ensembl chr 4:158,770,749...158,804,146
JBrowse link
G Cd80 Cd80 molecule multiple interactions ISO Sodium Benzoate inhibits the reaction [Adenine results in increased expression of CD80 mRNA] CTD PMID:36849798 NCBI chr11:75,760,073...75,798,978
Ensembl chr11:75,760,147...75,797,540
JBrowse link
G Cntf ciliary neurotrophic factor multiple interactions
increases expression
ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Sodium Benzoate results in increased expression of CNTF protein]; Sodium Benzoate results in increased expression of and results in increased secretion of CNTF protein
CREB1 affects the reaction [Sodium Benzoate results in increased expression of CNTF protein]; Sodium Benzoate promotes the reaction [CREB1 protein binds to CNTF promoter]; Sodium Benzoate promotes the reaction [CREBBP protein binds to CNTF promoter]
Sodium Benzoate results in increased expression of CNTF mRNA
CTD PMID:26399250 NCBI chr 1:219,312,512...219,314,535
Ensembl chr 1:219,312,512...219,314,488
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO Sodium Benzoate inhibits the reaction [arsenite results in increased expression of COL1A1 protein] CTD PMID:38703806 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions ISO Sodium Benzoate inhibits the reaction [arsenite results in increased expression of COL3A1 protein] CTD PMID:38703806 NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:54,866,632...54,903,232
JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 multiple interactions ISO Sodium Benzoate inhibits the reaction [arsenite results in increased expression of CPS1 protein] CTD PMID:38703806 NCBI chr 9:76,063,863...76,186,739
Ensembl chr 9:76,000,754...76,186,734
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
increases phosphorylation
ISO CREB1 protein promotes the reaction [Sodium Benzoate results in increased expression of GDNF mRNA]
Sodium Benzoate results in increased phosphorylation of CREB1 protein
CREB1 affects the reaction [Sodium Benzoate results in increased expression of CNTF protein]; CREB1 protein promotes the reaction [Sodium Benzoate results in increased expression of GDNF mRNA]; CREB1 protein promotes the reaction [Sodium Benzoate results in increased expression of TH protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Sodium Benzoate results in increased phosphorylation of CREB1 protein]; Sodium Benzoate promotes the reaction [CREB1 protein binds to CNTF promoter]
CTD PMID:26399250 PMID:31119595 PMID:34113786 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339
JBrowse link
G Crebbp CREB binding protein multiple interactions ISO Sodium Benzoate promotes the reaction [CREBBP protein binds to CNTF promoter] CTD PMID:26399250 NCBI chr10:11,842,307...11,968,266
Ensembl chr10:11,822,620...11,968,266
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Sodium Benzoate inhibits the reaction [[DAO protein results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA] CTD PMID:19860415 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 multiple interactions ISO Sodium Benzoate affects the reaction [Fructose affects the expression of CYP2A4 mRNA] CTD PMID:39519554 NCBI chr 1:91,299,584...91,307,650
Ensembl chr 1:91,299,561...91,307,649
JBrowse link
G Dao D-amino-acid oxidase multiple interactions
decreases activity
ISO
EXP
Sodium Benzoate inhibits the reaction [[DAO protein results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA]
Sodium Benzoate results in decreased activity of DAO protein
CTD PMID:19860415 PMID:20952482 PMID:36849798 NCBI chr12:48,252,900...48,275,964
Ensembl chr12:48,252,902...48,273,300
JBrowse link
G Esr1 estrogen receptor 1 decreases activity ISO Sodium Benzoate results in decreased activity of ESR1 protein CTD PMID:22562034 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354
JBrowse link
G Foxp3 forkhead box P3 increases expression
affects expression
ISO
EXP
Sodium Benzoate results in increased expression of FOXP3 mRNA
Sodium Benzoate affects the expression of FOXP3 mRNA
CTD PMID:27605008 PMID:32534510 NCBI chr  X:17,580,380...17,601,181
Ensembl chr  X:17,580,380...17,595,894
JBrowse link
G Fshb follicle stimulating hormone subunit beta increases expression EXP Sodium Benzoate results in increased expression of FSHB protein CTD PMID:32911041 NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:114,003,262...114,007,072
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions
decreases expression
ISO [Sodium Benzoate co-treated with Sorbic Acid] affects the expression of GADD45A mRNA
Sodium Benzoate results in decreased expression of GADD45A mRNA
CTD PMID:28229641 NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:97,484,502...97,486,807
JBrowse link
G Gbp4 guanylate binding protein 4 multiple interactions ISO Sodium Benzoate affects the reaction [Fructose affects the expression of GBP3 mRNA] CTD PMID:39519554 NCBI chr 2:233,978,163...233,992,124
Ensembl chr 2:233,978,486...233,992,120
JBrowse link
G Gdnf glial cell derived neurotrophic factor increases expression
multiple interactions
ISO Sodium Benzoate results in increased expression of GDNF mRNA; Sodium Benzoate results in increased expression of GDNF protein
CREB1 protein promotes the reaction [Sodium Benzoate results in increased expression of GDNF mRNA]
CREB1 protein promotes the reaction [Sodium Benzoate results in increased expression of GDNF mRNA]; GDNF protein promotes the reaction [Sodium Benzoate inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]]; Sodium Benzoate inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GDNF protein]
CTD PMID:31119595 NCBI chr 2:58,621,327...58,647,242
Ensembl chr 2:58,621,327...58,647,240
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO Sodium Benzoate inhibits the reaction [amyloid beta-protein (1-42) results in increased expression of GFAP protein] CTD PMID:32781134 NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 increases expression EXP Sodium Benzoate results in increased expression of GOT1 protein CTD PMID:37045926 NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871
JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression EXP Sodium Benzoate results in increased expression of GPT protein CTD PMID:37045926 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions ISO Sodium Benzoate inhibits the reaction [amyloid beta-protein (1-42) results in increased expression of GRIN1 protein] CTD PMID:32781134 NCBI chr 3:28,501,836...28,528,754
Ensembl chr 3:28,501,836...28,528,754
JBrowse link
G Hmox1 heme oxygenase 1 decreases expression
multiple interactions
EXP Sodium Benzoate results in decreased expression of HMOX1 protein
[Zinc Sulfate results in increased abundance of Zinc] inhibits the reaction [Sodium Benzoate results in decreased expression of HMOX1 protein]
CTD PMID:39106537 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818
JBrowse link
G Hnmt histamine N-methyltransferase multiple interactions ISO HNMT gene SNP affects the susceptibility to [6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt co-treated with azo rubin S co-treated with quinoline yellow co-treated with Allura Red AC Dye co-treated with Sodium Benzoate]; HNMT gene SNP affects the susceptibility to [6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt co-treated with azo rubin S co-treated with Tartrazine co-treated with ponceau 4R co-treated with Sodium Benzoate] CTD PMID:20551163 NCBI chr 3:26,978,274...27,010,291
Ensembl chr 3:26,977,933...27,010,482
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Sodium Benzoate inhibits the reaction [Adenine results in increased expression of ICAM1 mRNA] CTD PMID:36849798 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617
JBrowse link
G Ifng interferon gamma multiple interactions
affects expression
ISO
EXP
[Fructose co-treated with Sodium Benzoate] results in increased expression of IFNG protein; Sodium Benzoate inhibits the reaction [Lipopolysaccharides results in increased secretion of IFNG protein]
Sodium Benzoate affects the expression of IFNG mRNA
[Sodium Benzoate co-treated with MBP protein] results in decreased expression of IFNG mRNA; [Sodium Benzoate co-treated with MBP protein] results in decreased expression of IFNG protein
[Food Preservatives results in increased abundance of Sodium Benzoate] which results in increased expression of IFNG mRNA
CTD PMID:26706697 PMID:27611715 PMID:32179172 PMID:32534510 PMID:39519554 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216
JBrowse link
G Il10 interleukin 10 multiple interactions
affects expression
EXP [Food Preservatives results in increased abundance of Sodium Benzoate] which results in increased expression of IL10 mRNA
Sodium Benzoate affects the expression of IL10 mRNA
CTD PMID:32179172 PMID:32534510 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580
JBrowse link
G Il17a interleukin 17A multiple interactions ISO [Fructose co-treated with Sodium Benzoate] results in increased expression of IL17A protein CTD PMID:39519554 NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
EXP
ISO
[Food Preservatives results in increased abundance of Sodium Benzoate] which results in increased expression of IL1B mRNA; [Zinc Sulfate results in increased abundance of Zinc] inhibits the reaction [Sodium Benzoate results in increased expression of IL1B protein]; Coconut Oil inhibits the reaction [Sodium Benzoate results in increased expression of IL1B protein]
Sodium Benzoate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Sodium Benzoate inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]
Sodium Benzoate inhibits the reaction [Adenine results in increased expression of IL1B mRNA]
CTD PMID:32179172 PMID:36265761 PMID:36849798 PMID:38243570 PMID:39106537 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha increases expression ISO Sodium Benzoate results in increased expression of IL2RA mRNA CTD PMID:27605008 NCBI chr17:71,759,802...71,808,475
Ensembl chr17:71,759,802...71,808,507
JBrowse link
G Il4 interleukin 4 multiple interactions ISO [Sodium Benzoate co-treated with MBP protein] results in increased expression of IL4 mRNA; [Sodium Benzoate co-treated with MBP protein] results in increased expression of IL4 protein CTD PMID:27611715 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO
EXP
Sodium Benzoate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
[Food Preservatives results in increased abundance of Sodium Benzoate] which results in increased expression of IL6 mRNA
Sodium Benzoate results in increased expression of IL6 protein
CTD PMID:26706697 PMID:32179172 PMID:32911041 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Sodium Benzoate inhibits the reaction [amyloid beta-protein (1-42) results in increased phosphorylation of JUN protein] CTD PMID:32781134 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285
JBrowse link
G Lcn2 lipocalin 2 multiple interactions ISO Sodium Benzoate inhibits the reaction [Adenine results in increased expression of LCN2 mRNA] CTD PMID:36849798 NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:36,078,436...36,081,842
JBrowse link
G Ldha lactate dehydrogenase A multiple interactions ISO Sodium Benzoate inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of LDHA protein] CTD PMID:34113786 NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:106,502,182...106,517,521
JBrowse link
G Lhb luteinizing hormone subunit beta increases expression EXP Sodium Benzoate results in increased expression of LHB protein CTD PMID:32911041 NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:105,037,457...105,038,445
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Sodium Benzoate inhibits the reaction [Adenine results in increased phosphorylation of MAPK1 protein] CTD PMID:36849798 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Sodium Benzoate inhibits the reaction [Adenine results in increased phosphorylation of MAPK3 protein] CTD PMID:36849798 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
decreases expression
ISO [Sodium Benzoate co-treated with Sorbic Acid] results in increased expression of MAPK8 mRNA; Sodium Benzoate inhibits the reaction [Adenine results in increased phosphorylation of MAPK8 protein]; Sodium Benzoate inhibits the reaction [amyloid beta-protein (1-42) results in increased phosphorylation of MAPK8 protein]
Sodium Benzoate results in decreased expression of MAPK8 mRNA
Sodium Benzoate promotes the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]
CTD PMID:28229641 PMID:32781134 PMID:36849798 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427
JBrowse link
G Mbp myelin basic protein multiple interactions ISO [Sodium Benzoate co-treated with MBP protein] results in decreased expression of IFNG mRNA; [Sodium Benzoate co-treated with MBP protein] results in decreased expression of IFNG protein; [Sodium Benzoate co-treated with MBP protein] results in increased expression of IL4 mRNA; [Sodium Benzoate co-treated with MBP protein] results in increased expression of IL4 protein CTD PMID:27611715 NCBI chr18:78,130,652...78,241,174
Ensembl chr18:78,130,325...78,241,174
JBrowse link
G Mrc1 mannose receptor, C type 1 multiple interactions ISO Sodium Benzoate inhibits the reaction [Adenine results in increased expression of MRC1 mRNA] CTD PMID:36849798 NCBI chr17:82,157,725...82,239,411
Ensembl chr17:82,157,705...82,239,410
JBrowse link
G Msr1 macrophage scavenger receptor 1 multiple interactions ISO Sodium Benzoate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA alternative form]; Sodium Benzoate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA] CTD PMID:9614211 NCBI chr16:59,421,250...59,507,070
Ensembl chr16:59,421,057...59,507,070
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases expression
multiple interactions
EXP Sodium Benzoate results in decreased expression of NFE2L2 mRNA; Sodium Benzoate results in decreased expression of NFE2L2 protein
[Zinc Sulfate results in increased abundance of Zinc] inhibits the reaction [Sodium Benzoate results in decreased expression of NFE2L2 mRNA]; [Zinc Sulfate results in increased abundance of Zinc] inhibits the reaction [Sodium Benzoate results in decreased expression of NFE2L2 protein]; Coconut Oil inhibits the reaction [Sodium Benzoate results in decreased expression of NFE2L2 mRNA]
CTD PMID:36265761 PMID:38243570 PMID:39106537 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression
multiple interactions
EXP Sodium Benzoate results in increased expression of NFKB1 mRNA; Sodium Benzoate results in increased expression of NFKB1 protein
[Zinc Sulfate results in increased abundance of Zinc] inhibits the reaction [Sodium Benzoate results in increased expression of NFKB1 protein]; Coconut Oil affects the reaction [Sodium Benzoate results in increased expression of NFKB1 mRNA]
CTD PMID:37045926 PMID:38243570 PMID:39106537 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Sodium Benzoate inhibits the reaction [Adenine results in increased expression of NOS2 protein] CTD PMID:36849798 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
JBrowse link
G Nt5e 5' nucleotidase, ecto increases expression ISO Sodium Benzoate results in increased expression of NT5E mRNA CTD PMID:27605008 NCBI chr 8:98,150,925...98,195,646
Ensembl chr 8:98,150,900...98,195,645
JBrowse link
G Otc ornithine transcarbamylase multiple interactions ISO Sodium Benzoate affects the reaction [OTC gene mutant form affects the abundance of Hydroxyindoleacetic Acid]; Sodium Benzoate affects the reaction [OTC gene mutant form affects the metabolism of Glycine]; Sodium Benzoate affects the reaction [OTC gene mutant form affects the metabolism of Serotonin]; Sodium Benzoate affects the reaction [OTC gene mutant form results in increased abundance of Ammonium Compounds] CTD PMID:3091026 PMID:3374991 NCBI chr  X:15,126,358...15,202,473
Ensembl chr  X:15,126,358...15,239,555
JBrowse link
G Pla2g15 phospholipase A2, group XV increases expression ISO Sodium Benzoate results in increased expression of PLA2G15 protein CTD PMID:30154464 NCBI chr19:50,960,568...50,977,948
Ensembl chr19:50,960,598...50,977,946
JBrowse link
G Pla2g4c phospholipase A2 group IVC increases expression ISO Sodium Benzoate results in increased expression of PLA2G4C protein CTD PMID:30154464 NCBI chr 1:83,315,017...83,411,342
Ensembl chr 1:83,382,068...83,410,037
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO Sodium Benzoate results in increased expression of PTGS2 protein CTD PMID:30154464 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects localization
ISO Sodium Benzoate inhibits the reaction [Adenine results in increased phosphorylation of RELA protein]
Sodium Benzoate affects the localization of RELA protein
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Sodium Benzoate affects the localization of RELA protein]
CTD PMID:29565269 PMID:36849798 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit multiple interactions ISO Sodium Benzoate inhibits the reaction [Adenine results in increased expression of RELB mRNA]; Sodium Benzoate inhibits the reaction [Adenine results in increased expression of RELB protein]
Sodium Benzoate inhibits the reaction [Lipopolysaccharides results in increased expression of RELB mRNA]; Sodium Benzoate inhibits the reaction [Lipopolysaccharides results in increased expression of RELB protein]; Sodium Benzoate inhibits the reaction [TNF protein results in increased expression of RELB mRNA]
CTD PMID:36849798 NCBI chr 1:88,385,717...88,413,380
Ensembl chr 1:88,385,717...88,413,420
JBrowse link
G Sell selectin L increases expression ISO Sodium Benzoate results in increased expression of SELL mRNA CTD PMID:27605008 NCBI chr13:78,950,100...78,969,604
Ensembl chr13:78,950,015...78,969,600
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions ISO SLC6A3 gene SNP affects the susceptibility to [6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt co-treated with azo rubin S co-treated with quinoline yellow co-treated with Allura Red AC Dye co-treated with Sodium Benzoate]; SLC6A3 gene SNP affects the susceptibility to [6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt co-treated with azo rubin S co-treated with Tartrazine co-treated with ponceau 4R co-treated with Sodium Benzoate] CTD PMID:20551163 NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:31,537,990...31,578,962
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression EXP Sodium Benzoate results in decreased expression of SOD1 protein CTD PMID:37045926 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399
JBrowse link
G Stat6 signal transducer and activator of transcription 6 multiple interactions ISO Sodium Benzoate promotes the reaction [STAT6 protein binds to TGFB1 promoter]; Sodium Benzoate results in increased phosphorylation of and affects the localization of STAT6 protein CTD PMID:27605008 NCBI chr 7:65,365,505...65,382,825
Ensembl chr 7:65,365,306...65,383,795
JBrowse link
G Tbx21 T-box transcription factor 21 affects expression EXP Sodium Benzoate affects the expression of TBX21 mRNA CTD PMID:32534510 NCBI chr10:82,578,751...82,595,253
Ensembl chr10:82,578,751...82,595,253
JBrowse link
G Tfam transcription factor A, mitochondrial increases expression EXP Sodium Benzoate results in increased expression of TFAM protein CTD PMID:32911041 NCBI chr20:17,355,373...17,367,422
Ensembl chr20:17,355,363...17,369,877
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
affects expression
multiple interactions
ISO
EXP
Sodium Benzoate results in increased expression of TGFB1 mRNA
Sodium Benzoate affects the expression of TGFB1 mRNA
Sodium Benzoate inhibits the reaction [Adenine results in increased expression of TGFB1 mRNA]; Sodium Benzoate promotes the reaction [STAT6 protein binds to TGFB1 promoter]; Sodium Benzoate results in increased expression of and results in increased secretion of TGFB1 protein
CTD PMID:27605008 PMID:32534510 PMID:36849798 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899
JBrowse link
G Th tyrosine hydroxylase increases expression
multiple interactions
ISO Sodium Benzoate results in increased expression of TH mRNA; Sodium Benzoate results in increased expression of TH protein
CREB1 protein promotes the reaction [Sodium Benzoate results in increased expression of TH protein]; GDNF protein promotes the reaction [Sodium Benzoate inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]]; Sodium Benzoate inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]
CTD PMID:31119595 PMID:34113786 NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227
JBrowse link
G Tlr2 toll-like receptor 2 increases expression EXP Sodium Benzoate results in increased expression of TLR2 mRNA CTD PMID:37045926 NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194
JBrowse link
G Tlr4 toll-like receptor 4 increases expression EXP Sodium Benzoate results in increased expression of TLR4 mRNA CTD PMID:37045926 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007
JBrowse link
G Tnf tumor necrosis factor multiple interactions
affects expression
increases expression
ISO
EXP
[Fructose co-treated with Sodium Benzoate] results in increased expression of TNF protein; Sodium Benzoate inhibits the reaction [Adenine results in increased expression of TNF mRNA]; Sodium Benzoate inhibits the reaction [amyloid beta-protein (1-42) results in increased expression of TNF protein]; Sodium Benzoate inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Sodium Benzoate affects the expression of TNF mRNA
Sodium Benzoate inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Sodium Benzoate inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Sodium Benzoate inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]; Sodium Benzoate inhibits the reaction [TNF protein results in increased expression of RELB mRNA]; Sodium Benzoate inhibits the reaction [TNF protein results in increased expression of TNF mRNA]
[Food Preservatives results in increased abundance of Sodium Benzoate] which results in increased expression of TNF mRNA; [Zinc Sulfate results in increased abundance of Zinc] inhibits the reaction [Sodium Benzoate results in increased expression of TNF protein]; Ascorbic Acid inhibits the reaction [Sodium Benzoate results in increased expression of TNF protein]
Sodium Benzoate results in increased expression of TNF mRNA; Sodium Benzoate results in increased expression of TNF protein
CTD PMID:26706697 PMID:32179172 PMID:32534510 PMID:32781134 PMID:32911041 More... NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO
EXP
Sodium Benzoate inhibits the reaction [Asbestos, Amosite results in increased expression of TP53 mRNA]
Sodium Benzoate results in increased expression of TP53 protein
CTD PMID:16357363 PMID:32911041 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299
JBrowse link
G Ucp2 uncoupling protein 2 increases expression EXP Sodium Benzoate results in increased expression of UCP2 protein CTD PMID:32911041 NCBI chr 1:164,251,373...164,257,742
Ensembl chr 1:164,251,373...164,257,743
JBrowse link
G Vim vimentin multiple interactions ISO Sodium Benzoate inhibits the reaction [arsenite results in increased expression of VIM protein] CTD PMID:38703806 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746
JBrowse link
G Xdh xanthine dehydrogenase increases activity EXP Sodium Benzoate results in increased activity of XDH protein CTD PMID:32911041 NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:27,282,057...27,344,350
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      biological role 20831
        biochemical role 19888
          enzyme inhibitor 18710
            EC 3.* (hydrolase) inhibitor 17214
              EC 3.1.* (ester hydrolase) inhibitor 14877
                EC 3.1.1.* (carboxylic ester hydrolase) inhibitor 10677
                  EC 3.1.1.3 (triacylglycerol lipase) inhibitor 286
                    3-O-trans-p-coumaroyl actinidic acid 0
                    7-phloroeckol 0
                    atglistatin 0
                    benzaldehyde 9
                    benzoic acid + 75
                    galangin 92
                    gypsosaponin A 0
                    gypsosaponin B 0
                    gypsosaponin C 0
                    litseaefoloside C 0
                    orlistat 105
                    sodium benzoate + 80
paths to the root