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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:benzochromenone
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Accession:CHEBI:64986 term browser browse the term
Definition:A benzochromene in which the heterotricyclic ring system is substituted by an oxo group.
Synonyms:related_synonym: benzochromenones


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alternariol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor affects response to substance
multiple interactions
ISO AHR protein affects the susceptibility to alternariol
AHR protein affects the reaction [alternariol results in increased expression of CYP1A1 protein]
CTD PMID:22120949 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Alpp alkaline phosphatase, placental increases expression ISO alternariol results in increased expression of ALPP mRNA CTD PMID:32328700 NCBI chr 9:94,189,961...94,193,054
Ensembl chr 9:94,190,067...94,192,813
JBrowse link
G Ar androgen receptor decreases activity ISO alternariol results in decreased activity of AR protein CTD PMID:27481073 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions
affects response to substance
ISO ARNT protein affects the reaction [alternariol results in increased expression of CYP1A1 protein]
ARNT protein affects the susceptibility to alternariol
CTD PMID:22120949 NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179
JBrowse link
G Casp3 caspase 3 increases activity ISO alternariol results in increased activity of CASP3 protein CTD PMID:22542754 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 increases activity ISO alternariol results in increased activity of CASP9 protein CTD PMID:22542754 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccnd1 cyclin D1 increases expression
multiple interactions
ISO alternariol results in increased expression of CCND1 protein
6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [alternariol results in increased expression of CCND1 protein]; butaprost promotes the reaction [alternariol results in increased expression of CCND1 protein]
CTD PMID:30503586 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cd68 Cd68 molecule increases expression ISO alternariol results in increased expression of CD68 protein CTD PMID:26341179 NCBI chr10:56,268,726...56,270,605
Ensembl chr10:56,268,720...56,270,640
JBrowse link
G Cd83 CD83 molecule increases expression ISO alternariol results in increased expression of CD83 protein CTD PMID:26341179 NCBI chr17:24,416,651...24,435,790
Ensembl chr17:24,416,651...24,435,790
JBrowse link
G Cd86 CD86 molecule increases expression ISO alternariol results in increased expression of CD86 protein CTD PMID:26341179 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression
multiple interactions
ISO alternariol results in increased expression of CREB1 protein modified form
6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [alternariol results in increased expression of CREB1 protein modified form]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [alternariol results in increased expression of CREB1 protein modified form]
CTD PMID:30503586 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 decreases activity ISO alternariol results in decreased activity of CSNK2A1 protein CTD PMID:32328700 NCBI chr 3:147,713,808...147,760,375
Ensembl chr 3:147,713,821...147,757,862
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 increases expression ISO alternariol results in increased expression of CYP11B2 mRNA CTD PMID:23665424 NCBI chr 7:116,155,928...116,161,781
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression ISO alternariol results in increased expression of CYP17A1 mRNA CTD PMID:23665424 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression ISO alternariol results in increased expression of CYP19A1 mRNA CTD PMID:23665424 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
affects expression
affects activity
increases expression
ISO AHR protein affects the reaction [alternariol results in increased expression of CYP1A1 protein]; ARNT protein affects the reaction [alternariol results in increased expression of CYP1A1 protein]
alternariol affects the expression of CYP1A1 mRNA
alternariol affects the activity of CYP1A1 protein
alternariol results in increased expression of CYP1A1 mRNA
CTD PMID:22120949 PMID:23665424 PMID:26474839 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity ISO alternariol results in decreased activity of GSR protein CTD PMID:25827405 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 affects localization ISO alternariol affects the localization of GSTA1 mRNA CTD PMID:23154127 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 affects localization ISO alternariol affects the localization of GSTA2 mRNA CTD PMID:23154127 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G H2ax H2A.X variant histone increases expression ISO alternariol results in increased expression of H2AX protein modified form CTD PMID:26341179 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 increases expression ISO alternariol results in increased expression of HSD3B2 mRNA CTD PMID:23665424 NCBI chr 2:200,712,895...200,722,429
Ensembl chr 2:202,341,422...202,350,929
JBrowse link
G Il6 interleukin 6 increases expression
increases secretion
ISO alternariol results in increased expression of IL6 mRNA
alternariol results in increased secretion of IL6 protein
CTD PMID:26341179 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itgam integrin subunit alpha M increases expression ISO alternariol results in increased expression of ITGAM protein CTD PMID:26341179 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Mc2r melanocortin 2 receptor increases expression ISO alternariol results in increased expression of MC2R mRNA CTD PMID:23665424 NCBI chr18:64,166,959...64,178,729
Ensembl chr18:64,167,191...64,177,729
JBrowse link
G Mir192 microRNA 192 multiple interactions ISO [altertoxin II co-treated with alternariol] results in decreased expression of MIR192 mRNA CTD PMID:28007639 NCBI chr 1:221,634,971...221,635,080
Ensembl chr 1:221,634,971...221,635,080
JBrowse link
G Mir224 microRNA 224 multiple interactions ISO [altertoxin II co-treated with alternariol] results in increased expression of MIR224 mRNA CTD PMID:28007639 NCBI chr  X:152,223,754...152,223,835
Ensembl chr  X:152,223,754...152,223,835
JBrowse link
G Mir29a microRNA 29a increases expression ISO alternariol results in increased expression of MIR29A mRNA CTD PMID:28007639 NCBI chr 4:58,343,931...58,344,018 JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO alternariol results in decreased phosphorylation of MTOR protein CTD PMID:25456271 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects localization ISO alternariol affects the localization of NFE2L2 protein CTD PMID:23154127 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nr0b1 nuclear receptor subfamily 0, group B, member 1 decreases expression ISO alternariol results in decreased expression of NR0B1 mRNA CTD PMID:23665424 NCBI chr  X:54,734,385...54,738,513
Ensembl chr  X:54,734,385...54,738,513
JBrowse link
G Pgr progesterone receptor increases expression
multiple interactions
ISO alternariol results in increased expression of PGR protein
fulvestrant inhibits the reaction [alternariol results in increased expression of PGR protein]
CTD PMID:23665424 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Ptger2 prostaglandin E receptor 2 increases expression
multiple interactions
ISO alternariol results in increased expression of PTGER2 protein
6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [alternariol results in increased expression of PTGER2 protein]; butaprost promotes the reaction [alternariol results in increased expression of PTGER2 protein]
CTD PMID:30503586 NCBI chr15:19,336,029...19,349,759
Ensembl chr15:19,338,175...19,350,210
JBrowse link
G Ptger4 prostaglandin E receptor 4 multiple interactions
increases expression
ISO L-161982 inhibits the reaction [alternariol results in increased expression of PTGER4 protein] CTD PMID:30503586 NCBI chr 2:54,951,625...54,966,470
Ensembl chr 2:54,952,821...54,963,448
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO 6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [alternariol results in increased expression of PTGS2 protein]; butaprost promotes the reaction [alternariol results in increased expression of PTGS2 protein] CTD PMID:30503586 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO alternariol results in decreased phosphorylation of RPS6KB1 protein CTD PMID:25456271 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Sesn2 sestrin 2 increases expression ISO alternariol results in increased expression of SESN2 protein CTD PMID:25456271 NCBI chr 5:150,684,891...150,703,846
Ensembl chr 5:150,684,133...150,704,117
JBrowse link
G Tnf tumor necrosis factor increases secretion
increases expression
ISO alternariol results in increased secretion of TNF protein
alternariol results in increased expression of TNF mRNA
CTD PMID:26341179 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Top2a DNA topoisomerase II alpha decreases activity ISO alternariol metabolite results in decreased activity of TOP2A protein; alternariol results in decreased activity of TOP2A protein CTD PMID:27422292 PMID:27682608 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link
G Top2b DNA topoisomerase II beta decreases activity ISO alternariol metabolite results in decreased activity of TOP2B protein; alternariol results in decreased activity of TOP2B protein CTD PMID:27422292 NCBI chr15:10,262,972...10,319,741
Ensembl chr15:10,262,651...10,320,233
JBrowse link
G Tp53 tumor protein p53 increases expression ISO alternariol results in increased expression of TP53 protein CTD PMID:22542754 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
beta-lapachone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg7 autophagy related 7 affects response to substance ISO ATG7 protein affects the susceptibility to beta-lapachone CTD PMID:21035436 NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124
JBrowse link
G Becn1 beclin 1 affects response to substance ISO BECN1 protein affects the susceptibility to beta-lapachone CTD PMID:21035436 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO beta-lapachone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GSTP1 mRNA]; beta-lapachone inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA] CTD PMID:15313406 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO beta-lapachone affects the localization of and results in increased metabolism of MAP1LC3B protein CTD PMID:21035436 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases reduction ISO NQO1 protein results in increased reduction of beta-lapachone CTD PMID:24552538 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO beta-lapachone inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA] CTD PMID:15313406 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
splitomicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO [splitomicin results in decreased activity of SIRT1 protein] inhibits the reaction [6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one results in increased phosphorylation of ACACA protein]; [splitomicin results in decreased activity of SIRT1 protein] inhibits the reaction [resveratrol results in increased phosphorylation of ACACA protein] CTD PMID:18482975 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Casp3 caspase 3 multiple interactions ISO splitomicin promotes the reaction [Antimycin A results in increased cleavage of CASP3 protein] CTD PMID:24040102 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G F2 coagulation factor II multiple interactions ISO splitomicin promotes the reaction [F2 protein results in increased expression of F3 protein] CTD PMID:20978007 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO [Histamine co-treated with splitomicin] results in increased expression of F3 protein; splitomicin promotes the reaction [F2 protein results in increased expression of F3 protein]; splitomicin promotes the reaction [TNF protein results in increased expression of F3 mRNA]; splitomicin promotes the reaction [TNF protein results in increased expression of F3 protein] CTD PMID:20978007 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO splitomicin promotes the reaction [resveratrol results in decreased expression of FABP4 mRNA]; splitomicin promotes the reaction [resveratrol results in decreased expression of FABP4 protein] CTD PMID:23525482 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Kcna5 potassium voltage-gated channel subfamily A member 5 decreases expression EXP splitomicin results in decreased expression of KCNA5 mRNA CTD PMID:25447406 NCBI chr 4:159,077,195...159,079,003
Ensembl chr 4:159,077,195...159,079,003
JBrowse link
G Klkb1 kallikrein B1 increases response to substance
multiple interactions
ISO KLKB1 gene mutant form results in increased susceptibility to splitomicin
splitomicin inhibits the reaction [KLKB1 gene mutant form results in decreased susceptibility to Rose Bengal]
CTD PMID:25339356 NCBI chr16:50,151,127...50,175,407
Ensembl chr16:50,152,008...50,175,458
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO splitomicin promotes the reaction [resveratrol results in decreased expression of PPARG mRNA]; splitomicin promotes the reaction [resveratrol results in decreased expression of PPARG protein] CTD PMID:23525482 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions EXP splitomicin inhibits the reaction [[Nitrites co-treated with Oxygen deficiency] results in increased expression of PPARGC1A mRNA] CTD PMID:22892143 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO splitomicin promotes the reaction [TNF protein results in increased localization of and results in decreased acetylation of and results in increased activity of RELA protein] CTD PMID:20978007 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sirt1 sirtuin 1 decreases activity
multiple interactions
decreases expression
ISO
EXP
splitomicin results in decreased activity of SIRT1 protein
[splitomicin results in decreased activity of SIRT1 protein] inhibits the reaction [6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one results in increased phosphorylation of ACACA protein]; [splitomicin results in decreased activity of SIRT1 protein] inhibits the reaction [resveratrol results in increased phosphorylation of ACACA protein]
splitomicin results in decreased expression of SIRT1 mRNA
CTD PMID:18482975 PMID:20978007 PMID:25447406 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Tf transferrin increases activity ISO splitomicin results in increased activity of TF protein CTD PMID:20978007 NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO splitomicin promotes the reaction [TNF protein results in increased expression of F3 mRNA]; splitomicin promotes the reaction [TNF protein results in increased expression of F3 protein]; splitomicin promotes the reaction [TNF protein results in increased localization of and results in decreased acetylation of and results in increased activity of RELA protein] CTD PMID:20978007 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19883
    chemical entity 19883
      atom 19881
        nonmetal atom 19760
          oxygen atom 19425
            oxygen molecular entity 19425
              organooxygen compound 18886
                oxacycle 17299
                  benzochromene 74
                    benzochromenone 56
                      2,2,2-Trifluoro-N-(6-oxo-6H-dibenzo[b,d]pyran-2-yl)acetamide 0
                      3-bromo-beta-lapachone 0
                      6H-dibenzo[b,d]pyran-6-one + 0
                      Chartreusin 0
                      N-(6-Oxo-6H-dibenzo[b,d]pyran-3-yl)-2,2,2-trifluoroacetamide 0
                      Palmatoside G 0
                      altenuene 0
                      alternariol + 40
                      beta-lapachone 6
                      chaetochromin A 0
                      chaetochromin B 0
                      chaetochromin C 0
                      chaetochromin D 0
                      djalonensone 0
                      hyalodendriol C 0
                      nigerone 0
                      norrubrofusarin 0
                      palmariol B 0
                      rubrofusarin + 0
                      rubrofusarin B 0
                      splitomicin 13
                      urolithin A 3-O-glucuronide 0
                      urolithin A 8-O-glucuronide 0
                      ustilaginoidin A 0
                      viridaphin A1 glucoside 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19883
    subatomic particle 19881
      composite particle 19881
        hadron 19881
          baryon 19881
            nucleon 19881
              atomic nucleus 19881
                atom 19881
                  main group element atom 19771
                    p-block element atom 19771
                      carbon group element atom 19679
                        carbon atom 19668
                          organic molecular entity 19668
                            organic molecule 19596
                              organic cyclic compound 19407
                                organic heterocyclic compound 18517
                                  organic heteropolycyclic compound 17907
                                    organic heterotricyclic compound 14607
                                      benzochromene 74
                                        benzochromenone 56
                                          2,2,2-Trifluoro-N-(6-oxo-6H-dibenzo[b,d]pyran-2-yl)acetamide 0
                                          3-bromo-beta-lapachone 0
                                          6H-dibenzo[b,d]pyran-6-one + 0
                                          Chartreusin 0
                                          N-(6-Oxo-6H-dibenzo[b,d]pyran-3-yl)-2,2,2-trifluoroacetamide 0
                                          Palmatoside G 0
                                          altenuene 0
                                          alternariol + 40
                                          beta-lapachone 6
                                          chaetochromin A 0
                                          chaetochromin B 0
                                          chaetochromin C 0
                                          chaetochromin D 0
                                          djalonensone 0
                                          hyalodendriol C 0
                                          nigerone 0
                                          norrubrofusarin 0
                                          palmariol B 0
                                          rubrofusarin + 0
                                          rubrofusarin B 0
                                          splitomicin 13
                                          urolithin A 3-O-glucuronide 0
                                          urolithin A 8-O-glucuronide 0
                                          ustilaginoidin A 0
                                          viridaphin A1 glucoside 0
paths to the root