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G |
Ahr |
aryl hydrocarbon receptor |
affects response to substance multiple interactions |
ISO |
AHR protein affects the susceptibility to alternariol AHR protein affects the reaction [alternariol results in increased expression of CYP1A1 protein] |
CTD |
PMID:22120949 |
|
NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
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G |
Alpp |
alkaline phosphatase, placental |
increases expression |
ISO |
alternariol results in increased expression of ALPP mRNA |
CTD |
PMID:32328700 |
|
NCBI chr 9:94,189,961...94,193,054
Ensembl chr 9:94,190,067...94,192,813
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G |
Ar |
androgen receptor |
decreases activity |
ISO |
alternariol results in decreased activity of AR protein |
CTD |
PMID:27481073 |
|
NCBI chr X:67,656,253...67,828,998
Ensembl chr X:67,656,253...67,829,026
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|
G |
Arnt |
aryl hydrocarbon receptor nuclear translocator |
multiple interactions affects response to substance |
ISO |
ARNT protein affects the reaction [alternariol results in increased expression of CYP1A1 protein] ARNT protein affects the susceptibility to alternariol |
CTD |
PMID:22120949 |
|
NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179
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|
G |
Casp3 |
caspase 3 |
increases activity |
ISO |
alternariol results in increased activity of CASP3 protein |
CTD |
PMID:22542754 |
|
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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G |
Casp9 |
caspase 9 |
increases activity |
ISO |
alternariol results in increased activity of CASP9 protein |
CTD |
PMID:22542754 |
|
NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
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G |
Ccnd1 |
cyclin D1 |
increases expression multiple interactions |
ISO |
alternariol results in increased expression of CCND1 protein 6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [alternariol results in increased expression of CCND1 protein]; butaprost promotes the reaction [alternariol results in increased expression of CCND1 protein] |
CTD |
PMID:30503586 |
|
NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
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|
G |
Cd68 |
Cd68 molecule |
increases expression |
ISO |
alternariol results in increased expression of CD68 protein |
CTD |
PMID:26341179 |
|
NCBI chr10:56,268,726...56,270,605
Ensembl chr10:56,268,720...56,270,640
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|
G |
Cd83 |
CD83 molecule |
increases expression |
ISO |
alternariol results in increased expression of CD83 protein |
CTD |
PMID:26341179 |
|
NCBI chr17:24,416,651...24,435,790
Ensembl chr17:24,416,651...24,435,790
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|
G |
Cd86 |
CD86 molecule |
increases expression |
ISO |
alternariol results in increased expression of CD86 protein |
CTD |
PMID:26341179 |
|
NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
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|
G |
Creb1 |
cAMP responsive element binding protein 1 |
increases expression multiple interactions |
ISO |
alternariol results in increased expression of CREB1 protein modified form 6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [alternariol results in increased expression of CREB1 protein modified form]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [alternariol results in increased expression of CREB1 protein modified form] |
CTD |
PMID:30503586 |
|
NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
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|
G |
Csnk2a1 |
casein kinase 2 alpha 1 |
decreases activity |
ISO |
alternariol results in decreased activity of CSNK2A1 protein |
CTD |
PMID:32328700 |
|
NCBI chr 3:147,713,808...147,760,375
Ensembl chr 3:147,713,821...147,757,862
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|
G |
Cyp11b3 |
cytochrome P450, family 11, subfamily b, polypeptide 3 |
increases expression |
ISO |
alternariol results in increased expression of CYP11B2 mRNA |
CTD |
PMID:23665424 |
|
NCBI chr 7:116,155,928...116,161,781
Ensembl chr 7:116,156,219...116,255,167
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|
G |
Cyp17a1 |
cytochrome P450, family 17, subfamily a, polypeptide 1 |
increases expression |
ISO |
alternariol results in increased expression of CYP17A1 mRNA |
CTD |
PMID:23665424 |
|
NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
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|
G |
Cyp19a1 |
cytochrome P450, family 19, subfamily a, polypeptide 1 |
increases expression |
ISO |
alternariol results in increased expression of CYP19A1 mRNA |
CTD |
PMID:23665424 |
|
NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions affects expression affects activity increases expression |
ISO |
AHR protein affects the reaction [alternariol results in increased expression of CYP1A1 protein]; ARNT protein affects the reaction [alternariol results in increased expression of CYP1A1 protein] alternariol affects the expression of CYP1A1 mRNA alternariol affects the activity of CYP1A1 protein alternariol results in increased expression of CYP1A1 mRNA |
CTD |
PMID:22120949 PMID:23665424 PMID:26474839 |
|
NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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|
G |
Gsr |
glutathione-disulfide reductase |
decreases activity |
ISO |
alternariol results in decreased activity of GSR protein |
CTD |
PMID:25827405 |
|
NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
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G |
Gsta1 |
glutathione S-transferase alpha 1 |
affects localization |
ISO |
alternariol affects the localization of GSTA1 mRNA |
CTD |
PMID:23154127 |
|
NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
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G |
Gsta2 |
glutathione S-transferase alpha 2 |
affects localization |
ISO |
alternariol affects the localization of GSTA2 mRNA |
CTD |
PMID:23154127 |
|
NCBI chr 8:85,640,081...85,645,621
|
|
G |
H2ax |
H2A.X variant histone |
increases expression |
ISO |
alternariol results in increased expression of H2AX protein modified form |
CTD |
PMID:26341179 |
|
NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
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G |
Hsd3b2 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 |
increases expression |
ISO |
alternariol results in increased expression of HSD3B2 mRNA |
CTD |
PMID:23665424 |
|
NCBI chr 2:200,712,895...200,722,429
Ensembl chr 2:202,341,422...202,350,929
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G |
Il6 |
interleukin 6 |
increases expression increases secretion |
ISO |
alternariol results in increased expression of IL6 mRNA alternariol results in increased secretion of IL6 protein |
CTD |
PMID:26341179 |
|
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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|
G |
Itgam |
integrin subunit alpha M |
increases expression |
ISO |
alternariol results in increased expression of ITGAM protein |
CTD |
PMID:26341179 |
|
NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
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G |
Mc2r |
melanocortin 2 receptor |
increases expression |
ISO |
alternariol results in increased expression of MC2R mRNA |
CTD |
PMID:23665424 |
|
NCBI chr18:64,166,959...64,178,729
Ensembl chr18:64,167,191...64,177,729
|
|
G |
Mir192 |
microRNA 192 |
multiple interactions |
ISO |
[altertoxin II co-treated with alternariol] results in decreased expression of MIR192 mRNA |
CTD |
PMID:28007639 |
|
NCBI chr 1:221,634,971...221,635,080
Ensembl chr 1:221,634,971...221,635,080
|
|
G |
Mir224 |
microRNA 224 |
multiple interactions |
ISO |
[altertoxin II co-treated with alternariol] results in increased expression of MIR224 mRNA |
CTD |
PMID:28007639 |
|
NCBI chr X:152,223,754...152,223,835
Ensembl chr X:152,223,754...152,223,835
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|
G |
Mir29a |
microRNA 29a |
increases expression |
ISO |
alternariol results in increased expression of MIR29A mRNA |
CTD |
PMID:28007639 |
|
NCBI chr 4:58,343,931...58,344,018
|
|
G |
Mtor |
mechanistic target of rapamycin kinase |
decreases phosphorylation |
ISO |
alternariol results in decreased phosphorylation of MTOR protein |
CTD |
PMID:25456271 |
|
NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
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|
G |
Nfe2l2 |
nuclear factor, erythroid 2-like 2 |
affects localization |
ISO |
alternariol affects the localization of NFE2L2 protein |
CTD |
PMID:23154127 |
|
NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
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|
G |
Nr0b1 |
nuclear receptor subfamily 0, group B, member 1 |
decreases expression |
ISO |
alternariol results in decreased expression of NR0B1 mRNA |
CTD |
PMID:23665424 |
|
NCBI chr X:54,734,385...54,738,513
Ensembl chr X:54,734,385...54,738,513
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|
G |
Pgr |
progesterone receptor |
increases expression multiple interactions |
ISO |
alternariol results in increased expression of PGR protein fulvestrant inhibits the reaction [alternariol results in increased expression of PGR protein] |
CTD |
PMID:23665424 |
|
NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
|
|
G |
Ptger2 |
prostaglandin E receptor 2 |
increases expression multiple interactions |
ISO |
alternariol results in increased expression of PTGER2 protein 6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [alternariol results in increased expression of PTGER2 protein]; butaprost promotes the reaction [alternariol results in increased expression of PTGER2 protein] |
CTD |
PMID:30503586 |
|
NCBI chr15:19,336,029...19,349,759
Ensembl chr15:19,338,175...19,350,210
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|
G |
Ptger4 |
prostaglandin E receptor 4 |
multiple interactions increases expression |
ISO |
L-161982 inhibits the reaction [alternariol results in increased expression of PTGER4 protein] |
CTD |
PMID:30503586 |
|
NCBI chr 2:54,951,625...54,966,470
Ensembl chr 2:54,952,821...54,963,448
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions increases expression |
ISO |
6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [alternariol results in increased expression of PTGS2 protein]; butaprost promotes the reaction [alternariol results in increased expression of PTGS2 protein] |
CTD |
PMID:30503586 |
|
NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
|
|
G |
Rps6kb1 |
ribosomal protein S6 kinase B1 |
decreases phosphorylation |
ISO |
alternariol results in decreased phosphorylation of RPS6KB1 protein |
CTD |
PMID:25456271 |
|
NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
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|
G |
Sesn2 |
sestrin 2 |
increases expression |
ISO |
alternariol results in increased expression of SESN2 protein |
CTD |
PMID:25456271 |
|
NCBI chr 5:150,684,891...150,703,846
Ensembl chr 5:150,684,133...150,704,117
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|
G |
Tnf |
tumor necrosis factor |
increases secretion increases expression |
ISO |
alternariol results in increased secretion of TNF protein alternariol results in increased expression of TNF mRNA |
CTD |
PMID:26341179 |
|
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
|
|
G |
Top2a |
DNA topoisomerase II alpha |
decreases activity |
ISO |
alternariol metabolite results in decreased activity of TOP2A protein; alternariol results in decreased activity of TOP2A protein |
CTD |
PMID:27422292 PMID:27682608 |
|
NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
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G |
Top2b |
DNA topoisomerase II beta |
decreases activity |
ISO |
alternariol metabolite results in decreased activity of TOP2B protein; alternariol results in decreased activity of TOP2B protein |
CTD |
PMID:27422292 |
|
NCBI chr15:10,262,972...10,319,741
Ensembl chr15:10,262,651...10,320,233
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G |
Tp53 |
tumor protein p53 |
increases expression |
ISO |
alternariol results in increased expression of TP53 protein |
CTD |
PMID:22542754 |
|
NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
|
|
|
G |
Atg7 |
autophagy related 7 |
affects response to substance |
ISO |
ATG7 protein affects the susceptibility to beta-lapachone |
CTD |
PMID:21035436 |
|
NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124
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G |
Becn1 |
beclin 1 |
affects response to substance |
ISO |
BECN1 protein affects the susceptibility to beta-lapachone |
CTD |
PMID:21035436 |
|
NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
|
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G |
Gstp1 |
glutathione S-transferase pi 1 |
multiple interactions |
ISO |
beta-lapachone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GSTP1 mRNA]; beta-lapachone inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA] |
CTD |
PMID:15313406 |
|
NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
|
|
G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
multiple interactions |
ISO |
beta-lapachone affects the localization of and results in increased metabolism of MAP1LC3B protein |
CTD |
PMID:21035436 |
|
NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
|
|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases reduction |
ISO |
NQO1 protein results in increased reduction of beta-lapachone |
CTD |
PMID:24552538 |
|
NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
beta-lapachone inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA] |
CTD |
PMID:15313406 |
|
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
|
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|
G |
Acaca |
acetyl-CoA carboxylase alpha |
multiple interactions |
ISO |
[splitomicin results in decreased activity of SIRT1 protein] inhibits the reaction [6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one results in increased phosphorylation of ACACA protein]; [splitomicin results in decreased activity of SIRT1 protein] inhibits the reaction [resveratrol results in increased phosphorylation of ACACA protein] |
CTD |
PMID:18482975 |
|
NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
|
|
G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
splitomicin promotes the reaction [Antimycin A results in increased cleavage of CASP3 protein] |
CTD |
PMID:24040102 |
|
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
|
|
G |
F2 |
coagulation factor II |
multiple interactions |
ISO |
splitomicin promotes the reaction [F2 protein results in increased expression of F3 protein] |
CTD |
PMID:20978007 |
|
NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
|
|
G |
F3 |
coagulation factor III, tissue factor |
multiple interactions |
ISO |
[Histamine co-treated with splitomicin] results in increased expression of F3 protein; splitomicin promotes the reaction [F2 protein results in increased expression of F3 protein]; splitomicin promotes the reaction [TNF protein results in increased expression of F3 mRNA]; splitomicin promotes the reaction [TNF protein results in increased expression of F3 protein] |
CTD |
PMID:20978007 |
|
NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
|
|
G |
Fabp4 |
fatty acid binding protein 4 |
multiple interactions |
ISO |
splitomicin promotes the reaction [resveratrol results in decreased expression of FABP4 mRNA]; splitomicin promotes the reaction [resveratrol results in decreased expression of FABP4 protein] |
CTD |
PMID:23525482 |
|
NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
|
|
G |
Kcna5 |
potassium voltage-gated channel subfamily A member 5 |
decreases expression |
EXP |
splitomicin results in decreased expression of KCNA5 mRNA |
CTD |
PMID:25447406 |
|
NCBI chr 4:159,077,195...159,079,003
Ensembl chr 4:159,077,195...159,079,003
|
|
G |
Klkb1 |
kallikrein B1 |
increases response to substance multiple interactions |
ISO |
KLKB1 gene mutant form results in increased susceptibility to splitomicin splitomicin inhibits the reaction [KLKB1 gene mutant form results in decreased susceptibility to Rose Bengal] |
CTD |
PMID:25339356 |
|
NCBI chr16:50,151,127...50,175,407
Ensembl chr16:50,152,008...50,175,458
|
|
G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions |
ISO |
splitomicin promotes the reaction [resveratrol results in decreased expression of PPARG mRNA]; splitomicin promotes the reaction [resveratrol results in decreased expression of PPARG protein] |
CTD |
PMID:23525482 |
|
NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
|
|
G |
Ppargc1a |
PPARG coactivator 1 alpha |
multiple interactions |
EXP |
splitomicin inhibits the reaction [[Nitrites co-treated with Oxygen deficiency] results in increased expression of PPARGC1A mRNA] |
CTD |
PMID:22892143 |
|
NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
splitomicin promotes the reaction [TNF protein results in increased localization of and results in decreased acetylation of and results in increased activity of RELA protein] |
CTD |
PMID:20978007 |
|
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
|
|
G |
Sirt1 |
sirtuin 1 |
decreases activity multiple interactions decreases expression |
ISO EXP |
splitomicin results in decreased activity of SIRT1 protein [splitomicin results in decreased activity of SIRT1 protein] inhibits the reaction [6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one results in increased phosphorylation of ACACA protein]; [splitomicin results in decreased activity of SIRT1 protein] inhibits the reaction [resveratrol results in increased phosphorylation of ACACA protein] splitomicin results in decreased expression of SIRT1 mRNA |
CTD |
PMID:18482975 PMID:20978007 PMID:25447406 |
|
NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
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|
G |
Tf |
transferrin |
increases activity |
ISO |
splitomicin results in increased activity of TF protein |
CTD |
PMID:20978007 |
|
NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
splitomicin promotes the reaction [TNF protein results in increased expression of F3 mRNA]; splitomicin promotes the reaction [TNF protein results in increased expression of F3 protein]; splitomicin promotes the reaction [TNF protein results in increased localization of and results in decreased acetylation of and results in increased activity of RELA protein] |
CTD |
PMID:20978007 |
|
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
|
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