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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:bioconjugate
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Accession:CHEBI:64985 term browser browse the term
Definition:A molecular entity consisting of at least 2 biological molecules covalently linked together.
Synonyms:related_synonym: bio-conjugate;   bio-conjugates;   bioconjugates
 xref: Wikipedia:Bioconjugate


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Acetaminophen cystein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ggt1 gamma-glutamyltransferase 1 multiple interactions ISO GGT1 protein affects the reaction [acetaminophen cysteine results in decreased abundance of Glutathione] CTD PMID:15629191 NCBI chr20:13,074,141...13,103,551
Ensembl chr20:13,074,700...13,108,442 		JBrowse link
G Ptges prostaglandin E synthase multiple interactions ISO [PTGES protein affects the metabolism of Acetaminophen] which affects the abundance of acetaminophen cysteine; PTGES protein affects the reaction [Acetaminophen results in increased abundance of acetaminophen cysteine] CTD PMID:31444509 NCBI chr 3:34,575,643...34,586,987 JBrowse link
arachidonoyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO arachidonyl-coenzyme A binds to and results in increased activity of PPARA protein CTD PMID:11139385 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
palmitoyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acox1 acyl-CoA oxidase 1 increases metabolic processing
multiple interactions 		ISO ACOX1 protein results in increased metabolism of Palmitoyl Coenzyme A
[ACOX1 protein results in increased metabolism of Palmitoyl Coenzyme A] which results in increased chemical synthesis of Hydrogen Peroxide; benz(a)anthracene promotes the reaction [[ACOX1 protein results in increased metabolism of Palmitoyl Coenzyme A] which results in increased chemical synthesis of Hydrogen Peroxide]; Dehydroepiandrosterone promotes the reaction [[ACOX1 protein results in increased metabolism of Palmitoyl Coenzyme A] which results in increased chemical synthesis of Hydrogen Peroxide]; Tetrachlorodibenzodioxin promotes the reaction [[ACOX1 protein results in increased metabolism of Palmitoyl Coenzyme A] which results in increased chemical synthesis of Hydrogen Peroxide] 		CTD PMID:10497882 NCBI chr10:101,905,083...101,930,136
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Ces1d carboxylesterase 1D increases hydrolysis EXP CES1 protein results in increased hydrolysis of Palmitoyl Coenzyme A CTD PMID:8611161 NCBI chr19:30,046,494...30,085,039
Ensembl chr19:13,796,623...13,912,035 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions EXP valproyl-coenzyme A inhibits the reaction [CPT1A protein results in increased metabolism of Palmitoyl Coenzyme A] CTD PMID:19854160 NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 multiple interactions ISO DGAT1 protein results in increased metabolism of [Palmitoyl Coenzyme A co-treated with Vitamin A] CTD PMID:16214399 NCBI chr 7:110,104,514...110,119,091
Ensembl chr 7:108,218,524...108,234,299 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions ISO Palmitoyl Coenzyme A binds to and results in decreased activity of GSTA1 protein CTD PMID:10542059 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha decreases expression ISO Palmitoyl Coenzyme A results in decreased expression of HNF4A mRNA; Palmitoyl Coenzyme A results in decreased expression of HNF4A protein CTD PMID:17992261 NCBI chr 3:172,606,220...172,667,758
Ensembl chr 3:152,186,787...152,248,320 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO Palmitoyl Coenzyme A binds to and results in increased activity of PPARA protein
Acetylglucosamine inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Atorvastatin promotes the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Atropine inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Budesonide inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Enalapril inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Fenofibrate promotes the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; gamma-Aminobutyric Acid inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; gedunin inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]; Pravastatin promotes the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Pyrazinamide inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Saccharin inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; salicylamide inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Tolazoline inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Tolmetin inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]] 		CTD PMID:11139385 PMID:18812576 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO Palmitoyl Coenzyme A binds to and results in increased activity of PPARG protein CTD PMID:11139385 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Shbg sex hormone binding globulin decreases expression ISO Palmitoyl Coenzyme A results in decreased expression of SHBG mRNA; Palmitoyl Coenzyme A results in decreased expression of SHBG protein CTD PMID:17992261 NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057 		JBrowse link
S-(2,4-dinitrophenyl)glutathione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 affects export
affects transport
increases export
multiple interactions 		ISO ABCC1 protein affects the export of S-(2,4-dinitrophenyl)glutathione
ABCC1 protein affects the transport of S-(2,4-dinitrophenyl)glutathione
ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione
flavone inhibits the reaction [ABCC1 protein affects the export of S-(2,4-dinitrophenyl)glutathione]; hesperetin inhibits the reaction [ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]; Mefloquine inhibits the reaction [ABCC1 protein affects the transport of S-(2,4-dinitrophenyl)glutathione]; naringenin inhibits the reaction [ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]; Quercetin inhibits the reaction [ABCC1 protein affects the export of S-(2,4-dinitrophenyl)glutathione]; Quercetin inhibits the reaction [ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]; resveratrol inhibits the reaction [ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]; Silymarin inhibits the reaction [ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]; taxifolin inhibits the reaction [ABCC1 protein affects the export of S-(2,4-dinitrophenyl)glutathione]; verlukast inhibits the reaction [ABCC1 protein affects the transport of S-(2,4-dinitrophenyl)glutathione] 		CTD PMID:15041478 PMID:16004972 PMID:16156793 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
affects transport
increases export
increases transport 		EXP
ISO 		[Benzbromarone results in decreased activity of ABCC2 protein] inhibits the reaction [Glucose results in increased secretion of S-(2,4-dinitrophenyl)glutathione]; [Furosemide results in increased activity of ABCC2 protein] promotes the reaction [Glucose results in increased secretion of S-(2,4-dinitrophenyl)glutathione]; [Spironolactone results in increased expression of ABCC2 protein] which results in increased transport of S-(2,4-dinitrophenyl)glutathione; [sulfanitran results in increased activity of ABCC2 protein] promotes the reaction [Glucose results in increased secretion of S-(2,4-dinitrophenyl)glutathione]; Acetaminophen promotes the reaction [ABCC2 protein results in increased transport of S-(2,4-dinitrophenyl)glutathione]; S-(2,4-dinitrophenyl)glutathione inhibits the reaction [ABCC2 protein results in increased transport of temocaprilat]; temocaprilat inhibits the reaction [ABCC2 protein results in increased transport of S-(2,4-dinitrophenyl)glutathione]; Ursodeoxycholic Acid promotes the reaction [ABCC2 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]
ABCC2 protein affects the transport of S-(2,4-dinitrophenyl)glutathione 		CTD PMID:9067317 PMID:9430713 PMID:9525973 PMID:15276087 PMID:15652244 More... NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions ISO S-(2,4-dinitrophenyl)glutathione inhibits the reaction [ABCC4 protein results in increased transport of Methotrexate] CTD PMID:11856762 NCBI chr15:101,948,387...102,182,912
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20856
    chemical entity 20854
      atom 20854
        nonmetal atom 20762
          carbon atom 20704
            organic molecular entity 20704
              bioconjugate 14
                (8Z,11Z,14Z)-icosatrienoyl bioconjugate 0
                S-conjugate + 2
                alpha-linolenoyl bioconjugate + 0
                arachidonoyl bioconjugate + 1
                gamma-linolenoyl bioconjugate + 0
                glutathione conjugate + 3
                linoleoyl bioconjugate + 0
                omega-3-arachidonoyl bioconjugate 0
                palmitoyl bioconjugate + 9
                sapienoyl bioconjugate + 0
                stearidonoyl bioconjugate + 0
                timnodonoyl bioconjugate + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20856
    subatomic particle 20854
      composite particle 20854
        hadron 20854
          baryon 20854
            nucleon 20854
              atomic nucleus 20854
                atom 20854
                  main group element atom 20777
                    p-block element atom 20777
                      carbon group element atom 20710
                        carbon atom 20704
                          organic molecular entity 20704
                            bioconjugate 14
                              (8Z,11Z,14Z)-icosatrienoyl bioconjugate 0
                              S-conjugate + 2
                              alpha-linolenoyl bioconjugate + 0
                              arachidonoyl bioconjugate + 1
                              gamma-linolenoyl bioconjugate + 0
                              glutathione conjugate + 3
                              linoleoyl bioconjugate + 0
                              omega-3-arachidonoyl bioconjugate 0
                              palmitoyl bioconjugate + 9
                              sapienoyl bioconjugate + 0
                              stearidonoyl bioconjugate + 0
                              timnodonoyl bioconjugate + 0
paths to the root