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ONTOLOGY REPORT - ANNOTATIONS


Term:lipoxin A4
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Accession:CHEBI:6498 term browser browse the term
Definition:A C20 hydroxy fatty acid having (5S)-, (6R)- and (15S)-hydroxy groups as well as (7E)- (9E)-, (11Z)- and (13E)-double bonds.
Synonyms:related_synonym: (5S,6R,7E,9E,11Z,13E,15S)-5,6,15-trihydroxy-7,9,11,13-eicosatetraenoic acid;   (5S,6R,7E,9E,11Z,13E,15S)-5,6,15-trihydroxyeicosa-7,9,11,13-tetraenoic acid;   (7E,9E,11Z,13E)-(5S,6R,15S)-5,6,15-Trihydroxyicosa-7,9,11,13-tetraenoic acid;   5(S),6(R),15(S)-trihydroxyeicosa-7E,9E,11Z,13E-tetraenoic acid;   5S,6R,15S-Trihydroxy-7E,9E,11Z,13E-eicosatetraenoic acid;   5S,6R,15S-trihydroxy-7,9,13-trans-11-cis-eicosatetraenoic acid;   5S,6R-LipoxinA4;   6R-LXA4;   Formula=C20H32O5;   InChI=1S/C20H32O5/c1-2-3-8-12-17(21)13-9-6-4-5-7-10-14-18(22)19(23)15-11-16-20(24)25/h4-7,9-10,13-14,17-19,21-23H,2-3,8,11-12,15-16H2,1H3,(H,24,25)/b6-4-,7-5+,13-9+,14-10+/t17-,18+,19-/m0/s1;   InChIKey=IXAQOQZEOGMIQS-SSQFXEBMSA-N;   LXA4;   SMILES=CCCCC[C@H](O)\\C=C\\C=C/C=C/C=C/[C@@H](O)[C@@H](O)CCCC(O)=O
 xref: HMDB:HMDB0004385;   KEGG:C06314;   LIPID_MAPS_instance:LMFA03040001 "LIPID MAPS"
 xref_mesh: MESH:C040527
 xref: PMID:20435922 "Europe PMC";   PMID:20802423 "Europe PMC";   PMID:20833483 "Europe PMC";   PMID:20950211 "Europe PMC";   PMID:20959513 "Europe PMC";   PMID:21263017 "Europe PMC";   PMID:8690917 "Europe PMC";   Reaxys:4698639 "Reaxys"
 cyclic_relationship: is_conjugate_acid_of CHEBI:67026


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lipoxin A4 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ahr aryl-hydrocarbon receptor JBrowse link 12 35,497,979 35,534,989 RGD:6480464
G Alox5 arachidonate 5-lipoxygenase JBrowse link 6 116,410,071 116,461,178 RGD:6480464
G Bax BCL2-associated X protein JBrowse link 7 45,461,695 45,466,903 RGD:6480464
G Bcl2 B cell leukemia/lymphoma 2 JBrowse link 1 106,538,176 106,714,290 RGD:6480464
G Cxcl15 chemokine (C-X-C motif) ligand 15 JBrowse link 5 90,794,534 90,803,067 RGD:6480464
G Cxcl2 chemokine (C-X-C motif) ligand 2 JBrowse link 5 90,903,899 90,905,938 RGD:6480464
G Fpr2 formyl peptide receptor 2 JBrowse link 17 17,887,824 17,893,952 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 8 75,093,618 75,100,593 RGD:6480464
G Icam1 intercellular adhesion molecule 1 JBrowse link 9 21,015,940 21,028,814 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 2 129,364,569 129,371,164 RGD:6480464
G Il4 interleukin 4 JBrowse link 11 53,612,460 53,618,665 RGD:6480464
G Il6 interleukin 6 JBrowse link 5 30,013,114 30,019,975 RGD:6480464
G Mapk1 mitogen-activated protein kinase 1 JBrowse link 16 16,983,382 17,047,453 RGD:6480464
G Mapk3 mitogen-activated protein kinase 3 JBrowse link 7 126,759,626 126,765,816 RGD:6480464
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 JBrowse link 2 75,675,513 75,704,663 RGD:6480464
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha JBrowse link 12 55,489,409 55,492,647 RGD:6480464
G Nos2 nitric oxide synthase 2, inducible JBrowse link 11 78,920,787 78,960,226 RGD:6480464
G Pdgfb platelet derived growth factor, B polypeptide JBrowse link 15 79,995,865 80,024,614 RGD:6480464
G Pdgfrb platelet derived growth factor receptor, beta polypeptide JBrowse link 18 61,045,127 61,085,067 RGD:6480464
G Pparg peroxisome proliferator activated receptor gamma JBrowse link 6 115,360,879 115,490,404 RGD:6480464
G Ptafr platelet-activating factor receptor JBrowse link 4 132,564,067 132,582,683 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 1 150,100,031 150,108,234 RGD:6480464
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) JBrowse link 19 5,637,442 5,648,134 RGD:6480464
G Selp selectin, platelet JBrowse link 1 164,115,264 164,150,026 RGD:6480464
G Socs2 suppressor of cytokine signaling 2 JBrowse link 10 95,383,903 95,417,321 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 17 35,199,367 35,202,007 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20742
    role 20720
      biological role 20719
        biochemical role 19809
          metabolite 19732
            lipoxin A4 26
              20-hydroxylipoxin A4 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20742
    subatomic particle 20735
      composite particle 20735
        hadron 20735
          baryon 20735
            nucleon 20735
              atomic nucleus 20735
                atom 20735
                  main group element atom 20655
                    p-block element atom 20655
                      carbon group element atom 20391
                        carbon atom 20367
                          organic molecular entity 20367
                            organic group 19036
                              organic divalent group 19026
                                organodiyl group 19026
                                  carbonyl group 18997
                                    carbonyl compound 18997
                                      carboxylic acid 18668
                                        monocarboxylic acid 17887
                                          fatty acid 16343
                                            unsaturated fatty acid 899
                                              polyunsaturated fatty acid 653
                                                fatty acid 20:4 315
                                                  icosatetraenoic acid 315
                                                    icosa-5,8,11,14-tetraenoic acid 266
                                                      arachidonic acid 266
                                                        lipoxin 26
                                                          lipoxin A4 26
                                                            20-hydroxylipoxin A4 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.