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ONTOLOGY REPORT - ANNOTATIONS


Term:lipoxin A4
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Accession:CHEBI:6498 term browser browse the term
Definition:A C20 hydroxy fatty acid having (5S)-, (6R)- and (15S)-hydroxy groups as well as (7E)- (9E)-, (11Z)- and (13E)-double bonds.
Synonyms:related_synonym: (5S,6R,7E,9E,11Z,13E,15S)-5,6,15-trihydroxy-7,9,11,13-eicosatetraenoic acid;   (5S,6R,7E,9E,11Z,13E,15S)-5,6,15-trihydroxyeicosa-7,9,11,13-tetraenoic acid;   (7E,9E,11Z,13E)-(5S,6R,15S)-5,6,15-Trihydroxyicosa-7,9,11,13-tetraenoic acid;   5(S),6(R),15(S)-trihydroxyeicosa-7E,9E,11Z,13E-tetraenoic acid;   5S,6R,15S-Trihydroxy-7E,9E,11Z,13E-eicosatetraenoic acid;   5S,6R,15S-trihydroxy-7,9,13-trans-11-cis-eicosatetraenoic acid;   5S,6R-LipoxinA4;   6R-LXA4;   Formula=C20H32O5;   InChI=1S/C20H32O5/c1-2-3-8-12-17(21)13-9-6-4-5-7-10-14-18(22)19(23)15-11-16-20(24)25/h4-7,9-10,13-14,17-19,21-23H,2-3,8,11-12,15-16H2,1H3,(H,24,25)/b6-4-,7-5+,13-9+,14-10+/t17-,18+,19-/m0/s1;   InChIKey=IXAQOQZEOGMIQS-SSQFXEBMSA-N;   LXA4;   SMILES=CCCCC[C@H](O)\\C=C\\C=C/C=C/C=C/[C@@H](O)[C@@H](O)CCCC(O)=O
 xref: HMDB:HMDB0004385;   KEGG:C06314;   LIPID_MAPS_instance:LMFA03040001 "LIPID MAPS"
 xref_mesh: MESH:C040527
 xref: PMID:20435922 "Europe PMC";   PMID:20802423 "Europe PMC";   PMID:20833483 "Europe PMC";   PMID:20950211 "Europe PMC";   PMID:20959513 "Europe PMC";   PMID:21263017 "Europe PMC";   PMID:8690917 "Europe PMC";   Reaxys:4698639 "Reaxys"
 cyclic_relationship: is_conjugate_acid_of CHEBI:67026


show annotations for term's descendants       view all columns           Sort by:
 
lipoxin A4 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AHR aryl hydrocarbon receptor JBrowse link 7 17,298,652 17,346,147 RGD:6480464
G ALOX5 arachidonate 5-lipoxygenase JBrowse link 10 45,374,166 45,446,121 RGD:6480464
G BAX BCL2 associated X, apoptosis regulator JBrowse link 19 48,954,825 48,961,798 RGD:6480464
G BCL2 BCL2 apoptosis regulator JBrowse link 18 63,123,346 63,320,280 RGD:6480464
G CXCL2 C-X-C motif chemokine ligand 2 JBrowse link 4 74,097,040 74,099,195 RGD:6480464
G CXCL8 C-X-C motif chemokine ligand 8 JBrowse link 4 73,740,569 73,743,716 RGD:6480464
G FPR2 formyl peptide receptor 2 JBrowse link 19 51,752,026 51,770,531 RGD:6480464
G HMOX1 heme oxygenase 1 JBrowse link 22 35,381,096 35,394,207 RGD:6480464
G ICAM1 intercellular adhesion molecule 1 JBrowse link 19 10,271,120 10,286,615 RGD:6480464
G IL1B interleukin 1 beta JBrowse link 2 112,829,751 112,836,843 RGD:6480464
G IL4 interleukin 4 JBrowse link 5 132,673,986 132,682,678 RGD:6480464
G IL6 interleukin 6 JBrowse link 7 22,725,889 22,732,002 RGD:6480464
G MAPK1 mitogen-activated protein kinase 1 JBrowse link 22 21,759,657 21,867,680 RGD:6480464
G MAPK3 mitogen-activated protein kinase 3 JBrowse link 16 30,114,105 30,123,309 RGD:6480464
G NFE2L2 nuclear factor, erythroid 2 like 2 JBrowse link 2 177,230,303 177,265,131 RGD:6480464
G NFKBIA NFKB inhibitor alpha JBrowse link 14 35,401,510 35,404,754 RGD:6480464
G NOS2 nitric oxide synthase 2 JBrowse link 17 27,756,766 27,800,529 RGD:6480464
G PDGFB platelet derived growth factor subunit B JBrowse link 22 39,223,359 39,244,982 RGD:6480464
G PDGFRB platelet derived growth factor receptor beta JBrowse link 5 150,113,839 150,155,845 RGD:6480464
G PPARG peroxisome proliferator activated receptor gamma JBrowse link 3 12,287,485 12,434,356 RGD:6480464
G PTAFR platelet activating factor receptor JBrowse link 1 28,147,166 28,193,936 RGD:6480464
G PTGS2 prostaglandin-endoperoxide synthase 2 JBrowse link 1 186,671,791 186,680,423 RGD:6480464
G RELA RELA proto-oncogene, NF-kB subunit JBrowse link 11 65,653,596 65,662,972 RGD:6480464
G SELP selectin P JBrowse link 1 169,588,849 169,630,125 RGD:6480464
G SOCS2 suppressor of cytokine signaling 2 JBrowse link 12 93,569,849 93,626,236 RGD:6480464
G TNF tumor necrosis factor JBrowse link 6 31,575,565 31,578,336 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 23677
    role 23565
      biological role 23526
        biochemical role 22882
          metabolite 22770
            lipoxin A4 26
              20-hydroxylipoxin A4 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 23677
    subatomic particle 23624
      composite particle 23624
        hadron 23624
          baryon 23624
            nucleon 23624
              atomic nucleus 23624
                atom 23624
                  main group element atom 23441
                    p-block element atom 23441
                      carbon group element atom 23142
                        carbon atom 23118
                          organic molecular entity 23118
                            organic group 21814
                              organic divalent group 21784
                                organodiyl group 21784
                                  carbonyl group 21756
                                    carbonyl compound 21756
                                      carboxylic acid 20776
                                        monocarboxylic acid 19753
                                          fatty acid 18115
                                            unsaturated fatty acid 910
                                              polyunsaturated fatty acid 662
                                                fatty acid 20:4 315
                                                  icosatetraenoic acid 315
                                                    icosa-5,8,11,14-tetraenoic acid 266
                                                      arachidonic acid 266
                                                        lipoxin 26
                                                          lipoxin A4 26
                                                            20-hydroxylipoxin A4 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.