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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor
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Accession:CHEBI:64964 term browser browse the term
Definition:A lipoxygenase inhibitor that interferes with the action of arachidonate 5-lipoxygenase (EC 1.13.11.34).
Synonyms:related_synonym: 5-LOX inhibitor;   5-LOX inhibitors;   5-lipoxygenase inhibitor;   5-lipoxygenase inhibitors;   5delta-lipoxygenase inhibitor;   5delta-lipoxygenase inhibitors;   C-5-lipoxygenase inhibitor;   C-5-lipoxygenase inhibitors;   EC 1.13.11.34 inhibitor;   EC 1.13.11.34 inhibitors;   LTA synthase inhibitor;   LTA synthase inhibitors;   arachidonate 5-lipoxygenase (EC 1.13.11.34) inhibitors;   arachidonate 5-lipoxygenase inhibitor;   arachidonate 5-lipoxygenase inhibitors;   arachidonic 5-lipoxygenase inhibitor;   arachidonic 5-lipoxygenase inhibitors;   arachidonic acid 5-lipoxygenase inhibitor;   arachidonic acid 5-lipoxygenase inhibitors;   delta(5)-lipoxygenase inhibitor;   delta(5)-lipoxygenase inhibitors;   leukotriene A4 synthase inhibitors;   leukotriene-A4 synthase inhibitor


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3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcd2 ATP binding cassette subfamily D member 2 increases expression ISO MK-886 results in increased expression of ABCD2 mRNA CTD PMID:18292206 NCBI chr 7:122,263,034...122,311,642
Ensembl chr 7:122,263,032...122,311,642 		JBrowse link
G Acmsd aminocarboxymuconate semialdehyde decarboxylase multiple interactions EXP MK-886 inhibits the reaction [pirinixic acid results in decreased expression of ACMSD mRNA] CTD PMID:18320257 NCBI chr13:39,200,486...39,244,337
Ensembl chr13:39,200,314...39,245,209 		JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions
increases expression		 EXP
ISO		 MK-886 inhibits the reaction [pirinixic acid results in increased expression of ACOX1 mRNA]
MK-886 results in increased expression of ACOX1 mRNA		 CTD PMID:18292206 PMID:18320257 NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO MK-886 inhibits the reaction [Arsenic Trioxide results in increased expression of ACTA2 protein] CTD PMID:30677399 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase decreases activity
multiple interactions		 EXP
ISO		 MK-886 results in decreased activity of ALOX5 protein
EPHX2 gene mutant form promotes the reaction [MK-886 inhibits the reaction [Lipopolysaccharides results in increased expression of ALOX5 protein]]; MK-886 inhibits the reaction [Lipopolysaccharides results in increased expression of ALOX5 protein]
MK-886 inhibits the reaction [ALOX5 protein results in increased metabolism of Hydroxyeicosatetraenoic Acids metabolite]; MK-886 inhibits the reaction [Nicotine results in increased expression of ALOX5 protein]		 CTD PMID:9445378 PMID:11861792 PMID:14726295 PMID:19896470 PMID:20061081 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein multiple interactions
decreases activity		 ISO
EXP		 [MK-886 results in decreased activity of ALOX5AP protein] which results in decreased abundance of Leukotriene C4; MK-886 binds to and results in decreased activity of ALOX5AP protein; MK-886 inhibits the reaction [ALOX5AP protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]] CTD PMID:7990266 PMID:8058773 PMID:8666909 PMID:9113110 PMID:9609743 More... NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986 		JBrowse link
G Apoa1 apolipoprotein A1 decreases expression
multiple interactions		 ISO MK-886 results in decreased expression of APOA1 protein
MK-886 inhibits the reaction [TNF protein results in decreased expression of APOA1 mRNA]		 CTD PMID:19883121 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO MK-886 inhibits the reaction [Nicotine results in decreased expression of BAX protein] CTD PMID:20061081 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO MK-886 inhibits the reaction [Nicotine results in increased expression of BCL2 protein] CTD PMID:20061081 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO MK-886 inhibits the reaction [Nicotine results in decreased expression of CASP3 protein]
MK-886 results in increased activity of CASP3 protein		 CTD PMID:20061081 PMID:22308955 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP [13-hydroperoxy-9,11-octadecadienoic acid co-treated with MK-886] results in increased expression of CCL2 mRNA; [13-hydroperoxy-9,11-octadecadienoic acid co-treated with MK-886] results in increased expression of CCL2 protein CTD PMID:22135674 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO MK-886 inhibits the reaction [Nicotine results in increased expression of CCND1 mRNA]; MK-886 inhibits the reaction [Nicotine results in increased expression of CCND1 protein] CTD PMID:20061081 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccne1 cyclin E1 multiple interactions ISO MK-886 inhibits the reaction [Nicotine results in increased expression of CCNE1 protein] CTD PMID:20061081 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO [MK-886 binds to and results in decreased activity of PPARA protein] inhibits the reaction [perfluorooctanoic acid results in decreased expression of CDH1 protein]; MK-886 inhibits the reaction [Nicotine results in decreased expression of CDH1 mRNA] CTD PMID:20061081 PMID:23978332 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO [MK-886 binds to and results in decreased activity of PPARA protein] inhibits the reaction [perfluorooctanoic acid results in decreased expression of CTNNB1 protein] CTD PMID:23978332 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO MK-886 promotes the reaction [Dronabinol results in increased expression of CYP1A1 mRNA] CTD PMID:25291031 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions ISO MK-886 inhibits the reaction [Nicotine results in increased expression of E2F1 protein] CTD PMID:20061081 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G Egr1 early growth response 1 multiple interactions EXP [13-hydroperoxy-9,11-octadecadienoic acid co-treated with MK-886] results in increased expression of EGR1 mRNA; [13-hydroperoxy-9,11-octadecadienoic acid co-treated with MK-886] results in increased expression of EGR1 protein CTD PMID:22135674 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Ephx2 epoxide hydrolase 2 multiple interactions ISO EPHX2 gene mutant form promotes the reaction [[Lipopolysaccharides co-treated with MK-886] results in decreased abundance of 11,12-dihydroxyeicosatrienoic acid]; EPHX2 gene mutant form promotes the reaction [[Lipopolysaccharides co-treated with MK-886] results in decreased abundance of 14,15-dihydroxyeicosatrienoic acid]; EPHX2 gene mutant form promotes the reaction [MK-886 inhibits the reaction [Lipopolysaccharides results in increased abundance of 5-hydroxy-6,8,11,14-eicosatetraenoic acid]]; EPHX2 gene mutant form promotes the reaction [MK-886 inhibits the reaction [Lipopolysaccharides results in increased expression of ALOX5 protein]]; MK-886 promotes the reaction [EPHX2 gene mutant form results in decreased susceptibility to Lipopolysaccharides] CTD PMID:19896470 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615 		JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO MK-886 inhibits the reaction [3-((O-6-deoxymannopyranosyl-1-2-O-(xylopyranosyl-1-3)arabinopyranosyl)oxy)-21-glucopyranosyloxy-20-hydroxydammar-24-en-19-al inhibits the reaction [Lipopolysaccharides results in increased activity of F3 protein]]; MK-886 inhibits the reaction [pirinixic acid inhibits the reaction [Lipopolysaccharides results in increased activity of F3 protein]] CTD PMID:17141290 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Fa2h fatty acid 2-hydroxylase multiple interactions ISO MK-886 inhibits the reaction [Dronabinol results in increased expression of FA2H mRNA]; MK-886 promotes the reaction [Dronabinol results in increased expression of FA2H mRNA] CTD PMID:23535410 PMID:25291031 NCBI chr19:39,312,904...39,364,153
Ensembl chr19:39,312,906...39,364,153 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO MK-886 inhibits the reaction [Zymosan results in increased secretion of IL10 protein] CTD PMID:16313356 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO MK-886 promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:19896470 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Lpl lipoprotein lipase multiple interactions ISO MK-886 inhibits the reaction [mangiferin results in increased activity of LPL protein]; MK-886 inhibits the reaction [mangiferin results in increased expression of LPL mRNA]; MK-886 inhibits the reaction [Plant Extracts results in increased activity of LPL protein]; MK-886 inhibits the reaction [Plant Extracts results in increased expression of LPL mRNA] CTD PMID:15975614 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249 		JBrowse link
G Ltb4r leukotriene B4 receptor multiple interactions EXP MK-886 binds to and results in decreased activity of LTB4R protein; MK-886 inhibits the reaction [LTB4R protein results in increased susceptibility to Formaldehyde] CTD PMID:19835937 NCBI chr15:29,263,126...29,265,716 JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO MK-886 inhibits the reaction [Arsenic Trioxide results in increased cleavage of MAP1LC3B protein] CTD PMID:30677399 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Mmp7 matrix metallopeptidase 7 multiple interactions ISO MK-886 inhibits the reaction [Nicotine results in increased expression of MMP7 mRNA] CTD PMID:20061081 NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO MK-886 inhibits the reaction [Nicotine results in increased expression of MMP9 mRNA]
MK-886 inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of MMP9 protein]		 CTD PMID:19837106 PMID:20061081 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO [fulvestrant co-treated with MK-886] inhibits the reaction [resveratrol results in increased expression of NOS3 mRNA] CTD PMID:21791144 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 multiple interactions ISO MK-886 inhibits the reaction [Bezafibrate results in increased expression of PDK4 mRNA]; MK-886 inhibits the reaction [Bezafibrate results in increased expression of PDK4 protein] CTD PMID:19683050 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850 		JBrowse link
G Pla2g4a phospholipase A2 group IVA multiple interactions ISO MK-886 inhibits the reaction [Histamine results in increased expression of PLA2G4A mRNA] CTD PMID:9609743 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266 		JBrowse link
G Plau plasminogen activator, urokinase multiple interactions ISO MK-886 inhibits the reaction [Nicotine results in increased expression of PLAU mRNA] CTD PMID:20061081 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Plaur plasminogen activator, urokinase receptor multiple interactions ISO MK-886 inhibits the reaction [Nicotine results in increased expression of PLAUR mRNA] CTD PMID:20061081 NCBI chr 1:80,053,441...80,068,384
Ensembl chr 1:80,050,324...80,068,595 		JBrowse link
G Poli DNA polymerase iota decreases activity ISO MK-886 results in decreased activity of POLI protein CTD PMID:23305233 NCBI chr18:64,116,774...64,134,373
Ensembl chr18:64,116,774...64,163,418 		JBrowse link
G Polk DNA polymerase kappa decreases activity ISO MK-886 results in decreased activity of POLK protein CTD PMID:23305233 NCBI chr 2:27,822,228...27,882,331
Ensembl chr 2:27,822,679...27,882,313 		JBrowse link
G Polm DNA polymerase mu decreases activity ISO MK-886 results in decreased activity of POLM protein CTD PMID:23305233 NCBI chr14:80,707,075...80,716,677
Ensembl chr14:80,706,345...80,717,086 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
increases expression		 ISO
EXP		 [MK-886 binds to and results in decreased activity of PPARA protein] inhibits the reaction [perfluorooctanoic acid results in decreased expression of CDH1 protein]; [MK-886 binds to and results in decreased activity of PPARA protein] inhibits the reaction [perfluorooctanoic acid results in decreased expression of CTNNB1 protein]; [MK-886 binds to and results in decreased activity of PPARA protein] which results in decreased susceptibility to perfluorooctanoic acid; MK-886 binds to and results in decreased activity of PPARA protein; MK-886 inhibits the reaction [Arsenic Trioxide results in increased expression of PPARA protein]; MK-886 inhibits the reaction [Bezafibrate results in increased expression of PPARA mRNA]; MK-886 inhibits the reaction [mangiferin results in increased activity of PPARA protein]; MK-886 inhibits the reaction [perfluorooctane sulfonic acid results in increased activity of PPARA protein]; MK-886 inhibits the reaction [perfluorooctanoic acid results in increased activity of PPARA protein]; MK-886 inhibits the reaction [Plant Extracts results in increased activity of PPARA protein]; MK-886 promotes the reaction [Dronabinol results in increased expression of PPARA mRNA]
MK-886 binds to and results in decreased activity of PPARA protein; MK-886 inhibits the reaction [perfluorooctane sulfonic acid results in increased activity of PPARA protein]; MK-886 inhibits the reaction [perfluorooctanoic acid results in increased activity of PPARA protein]
[MK-886 binds to and results in decreased activity of PPARA protein] which results in decreased susceptibility to palmidrol analog; MK-886 binds to and results in decreased activity of PPARA protein
MK-886 results in increased expression of PPARA mRNA		 CTD PMID:15899809 PMID:15975614 PMID:17047030 PMID:17558434 PMID:18292206 More... NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases activity
increases expression
affects localization
multiple interactions		 ISO MK-886 results in increased activity of PPARG protein
MK-886 results in increased expression of PPARG mRNA
MK-886 affects the localization of PPARG protein
[Indomethacin co-treated with MK-886] affects the localization of PPARG protein; Indomethacin promotes the reaction [MK-886 results in increased activity of PPARG protein]		 CTD PMID:15899809 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ptges prostaglandin E synthase decreases activity ISO MK-886 results in decreased activity of PTGES protein CTD PMID:20933508 PMID:25451575 NCBI chr 3:14,177,892...14,189,236 JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO MK-886 inhibits the reaction [Nicotine results in increased expression of RB1 protein modified form] CTD PMID:20061081 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO MK-886 inhibits the reaction [pirinixic acid results in decreased phosphorylation of RELA protein] CTD PMID:17371993 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rxra retinoid X receptor alpha multiple interactions
increases expression		 ISO [MK-886 co-treated with Indomethacin] results in increased expression of RXRA mRNA
MK-886 results in increased expression of RXRA mRNA		 CTD PMID:15899809 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712 		JBrowse link
G S100b S100 calcium binding protein B multiple interactions EXP MK-886 inhibits the reaction [pirinixic acid affects the expression of S100B protein] CTD PMID:16863991 NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743 		JBrowse link
G Selp selectin P multiple interactions ISO MK-886 inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein] CTD PMID:11116075 NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO MK-886 promotes the reaction [SOD2 gene mutant form results in decreased abundance of Adenosine Triphosphate]; MK-886 promotes the reaction [SOD2 gene mutant form results in increased abundance of Lactic Acid] CTD PMID:25362851 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Tfdp1 transcription factor Dp-1 multiple interactions ISO MK-886 inhibits the reaction [Nicotine results in increased expression of TFDP1 protein] CTD PMID:20061081 NCBI chr16:76,162,040...76,200,871
Ensembl chr16:76,162,043...76,200,817 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Ovalbumin co-treated with MK-886] results in increased expression of TNF protein; MK-886 inhibits the reaction [TNF protein results in decreased expression of APOA1 mRNA]; monascin inhibits the reaction [[Ovalbumin co-treated with MK-886] results in increased expression of TNF protein] CTD PMID:19883121 PMID:22381257 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions EXP MK-886 inhibits the reaction [pirinixic acid results in increased expression of UCP2 mRNA]; MK-886 inhibits the reaction [pirinixic acid results in increased expression of UCP2 protein] CTD PMID:16782780 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611 		JBrowse link
acteoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle decreases expression ISO acteoside results in decreased expression of ACTA2 protein CTD PMID:33522686 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Ager advanced glycosylation end product-specific receptor decreases expression ISO acteoside results in decreased expression of AGER protein CTD PMID:33522686 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
decreases localization		 ISO acteoside promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased localization of AHR protein]
acteoside results in decreased localization of AHR protein		 CTD PMID:21756928 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator increases localization ISO acteoside results in increased localization of ARNT protein CTD PMID:21756928 NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression
multiple interactions
decreases secretion		 ISO acteoside results in decreased expression of CCL2 mRNA
acteoside inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 mRNA]
acteoside results in decreased secretion of CCL2 protein		 CTD PMID:21756928 PMID:21967610 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO acteoside results in decreased expression of CCND1 protein CTD PMID:17634406 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccnd2 cyclin D2 decreases expression ISO acteoside results in decreased expression of CCND2 protein CTD PMID:17634406 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495 		JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO acteoside results in decreased expression of CCND3 protein CTD PMID:17634406 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371 		JBrowse link
G Ccne1 cyclin E1 decreases expression ISO acteoside results in decreased expression of CCNE1 protein CTD PMID:17634406 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cdh1 cadherin 1 increases expression ISO acteoside results in increased expression of CDH1 protein CTD PMID:33522686 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO acteoside results in decreased expression of and results in decreased activity of CDK2 protein CTD PMID:17634406 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions
decreases activity		 ISO acteoside promotes the reaction [CDKN1A protein binds to CDK4 protein]; acteoside promotes the reaction [CDKN1B protein binds to CDK4 protein]
acteoside results in decreased activity of CDK4 protein		 CTD PMID:17634406 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 multiple interactions ISO acteoside promotes the reaction [CDKN1A protein binds to CDK6 protein]; acteoside promotes the reaction [CDKN1B protein binds to CDK6 protein]; acteoside results in decreased expression of and results in decreased activity of CDK6 protein CTD PMID:17634406 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions		 ISO acteoside results in increased expression of CDKN1A mRNA; acteoside results in increased expression of CDKN1A protein
acteoside promotes the reaction [CDKN1A protein binds to CDK4 protein]; acteoside promotes the reaction [CDKN1A protein binds to CDK6 protein]		 CTD PMID:17634406 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions
increases expression		 ISO acteoside promotes the reaction [CDKN1B protein binds to CDK4 protein]; acteoside promotes the reaction [CDKN1B protein binds to CDK6 protein]
acteoside results in increased expression of CDKN1B mRNA; acteoside results in increased expression of CDKN1B protein		 CTD PMID:17634406 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases secretion
decreases expression
multiple interactions		 ISO acteoside results in decreased secretion of CXCL10 protein
acteoside results in decreased expression of CXCL10 mRNA
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; acteoside inhibits the reaction [PD168393 results in increased secretion of CXCL10 protein]; acteoside promotes the reaction [leptomycin B results in decreased secretion of CXCL10 protein]		 CTD PMID:21756928 PMID:21967610 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO acteoside results in increased expression of CYP1A1 mRNA CTD PMID:21756928 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP acteoside inhibits the reaction [Carbon Tetrachloride results in increased expression of and results in increased activity of CYP2E1 protein] CTD PMID:14672760 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions ISO [acteoside results in decreased phosphorylation of RB1 protein] promotes the reaction [RB1 protein binds to E2F1 protein] CTD PMID:17634406 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G Egfr epidermal growth factor receptor decreases phosphorylation
multiple interactions		 ISO acteoside results in decreased phosphorylation of EGFR protein
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of EGFR protein]; acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein modified form]; acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein]		 CTD PMID:21756928 PMID:21967610 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Hmgb1 high mobility group box 1 decreases expression ISO acteoside results in decreased expression of HMGB1 protein CTD PMID:33522686 NCBI chr12:5,973,062...5,978,565
Ensembl chr12:5,901,586...5,978,565 		JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO acteoside results in decreased expression of ICAM1 mRNA CTD PMID:21371465 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ifng interferon gamma decreases expression
multiple interactions		 ISO acteoside results in decreased expression of IFNG mRNA
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of EGFR protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL8 protein]		 CTD PMID:21371465 PMID:21756928 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression		 ISO acteoside inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]
acteoside results in decreased expression of IL6 mRNA		 CTD PMID:21756928 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itgb2 integrin subunit beta 2 multiple interactions ISO acteoside inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGB2 protein]; acteoside inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB2 protein] CTD PMID:16393473 NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
increases phosphorylation		 ISO acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]
acteoside results in decreased phosphorylation of MAPK1 protein
acteoside results in increased phosphorylation of MAPK1 protein		 CTD PMID:21756928 PMID:23527233 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
decreases phosphorylation		 ISO acteoside results in increased phosphorylation of MAPK3 protein
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]
acteoside results in decreased phosphorylation of MAPK3 protein		 CTD PMID:21756928 PMID:23527233 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Nox1 NADPH oxidase 1 decreases activity ISO acteoside results in decreased activity of NOX1 protein CTD PMID:16393473 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236 		JBrowse link
G Ptgds prostaglandin D2 synthase affects binding ISO acteoside binds to PTGDS protein CTD PMID:26456343 NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [acteoside co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of PTGS2 mRNA CTD PMID:21756928 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rac1 Rac family small GTPase 1 decreases expression ISO Verbascoside decreases expression of RAC1 mRNA in colon cancer cells RGD PMID:29886834 RGD:153298971 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation
multiple interactions		 ISO acteoside results in decreased phosphorylation of RB1 protein
[acteoside results in decreased phosphorylation of RB1 protein] promotes the reaction [RB1 protein binds to E2F1 protein]		 CTD PMID:17634406 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases phosphorylation
multiple interactions
decreases phosphorylation		 ISO acteoside results in increased phosphorylation of RELA protein
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; acteoside inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RELA protein]
acteoside results in decreased phosphorylation of RELA protein		 CTD PMID:21756928 PMID:23527233 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Smad2 SMAD family member 2 increases phosphorylation ISO acteoside results in increased phosphorylation of SMAD2 protein CTD PMID:17634406 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323 		JBrowse link
G Smad3 SMAD family member 3 increases phosphorylation ISO acteoside results in increased phosphorylation of SMAD3 protein CTD PMID:17634406 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Smad7 SMAD family member 7 increases expression ISO acteoside results in increased expression of SMAD7 protein CTD PMID:33522686 NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765 		JBrowse link
G Snai1 snail family transcriptional repressor 1 decreases expression ISO acteoside results in decreased expression of SNAI1 protein CTD PMID:33522686 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969 		JBrowse link
G Snai2 snail family transcriptional repressor 2 decreases expression ISO acteoside results in decreased expression of SNAI2 protein CTD PMID:33522686 NCBI chr11:86,183,800...86,186,109
Ensembl chr11:86,181,909...86,186,200 		JBrowse link
G Sod2 superoxide dismutase 2 decreases expression ISO acteoside results in decreased expression of SOD2 mRNA CTD PMID:21371465 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Tgfa transforming growth factor alpha multiple interactions ISO [acteoside co-treated with TGFA protein] results in increased expression of CXCL8 mRNA; acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein modified form]; acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein] CTD PMID:21756928 PMID:21967610 NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO acteoside results in increased expression of TGFB1 mRNA CTD PMID:17634406 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 decreases expression ISO acteoside results in decreased expression of TGFBR1 protein CTD PMID:33522686 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 decreases expression ISO acteoside results in decreased expression of TGFBR2 protein CTD PMID:33522686 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of EGFR protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL8 protein] CTD PMID:21756928 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression ISO acteoside results in decreased expression of VCAM1 mRNA CTD PMID:21371465 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
azelastine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity
multiple interactions		 ISO azelastine results in decreased activity of ABCB1 protein
azelastine inhibits the reaction [ABCB1 protein results in increased transport of Daunorubicin]; azelastine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]		 CTD PMID:11231118 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Ache acetylcholinesterase decreases activity ISO azelastine results in decreased activity of ACHE protein CTD PMID:33844597 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO azelastine results in decreased expression of COL1A1 mRNA CTD PMID:8919039 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col3a1 collagen type III alpha 1 chain decreases expression ISO azelastine results in decreased expression of COL3A1 mRNA CTD PMID:8919039 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Col6a1 collagen type VI alpha 1 chain decreases expression ISO azelastine results in decreased expression of COL6A1 mRNA CTD PMID:8919039 NCBI chr20:11,906,105...11,924,599
Ensembl chr20:11,905,957...11,924,597 		JBrowse link
G Hrh1 histamine receptor H 1 affects binding ISO azelastine binds to HRH1 protein CTD PMID:2540229 NCBI chr 4:147,564,781...147,649,353
Ensembl chr 4:147,645,995...147,647,455 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO azelastine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO azelastine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
benoxaprofen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin decreases response to substance ISO ALB protein results in decreased susceptibility to benoxaprofen CTD PMID:6699424 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Alox12 arachidonate 12-lipoxygenase, 12S type decreases activity EXP benoxaprofen results in decreased activity of ALOX12 protein CTD PMID:3928952 NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase decreases activity
multiple interactions		 ISO
EXP		 benoxaprofen results in decreased activity of ALOX5 protein
[benoxaprofen results in decreased activity of ALOX5 protein] which results in decreased chemical synthesis of Leukotriene B4; [benoxaprofen results in decreased activity of ALOX5 protein] which results in increased abundance of 15-hydroxy-5,8,11,13-eicosatetraenoic acid		 CTD PMID:2724698 PMID:2849922 PMID:3020588 PMID:3928952 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
decreases activity		 EXP
ISO		 benoxaprofen results in increased expression of CYP1A1 protein
benoxaprofen results in decreased activity of CYP1A1 protein		 CTD PMID:2069584 PMID:33814510 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression EXP benoxaprofen results in increased expression of CYP1A2 protein CTD PMID:2069584 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO benoxaprofen results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 increases expression EXP benoxaprofen results in increased expression of CYP4A1 protein CTD PMID:2069584 NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464 		JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase increases expression EXP benoxaprofen results in increased expression of EHHADH protein CTD PMID:2069584 NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188 		JBrowse link
G Gusb glucuronidase, beta increases secretion ISO benoxaprofen results in increased secretion of GUSB protein CTD PMID:6737371 NCBI chr12:26,701,191...26,714,718
Ensembl chr12:26,697,951...26,726,905 		JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP benoxaprofen inhibits the reaction [LHB protein results in increased abundance of Pregnenolone]; benoxaprofen inhibits the reaction [LHB protein results in increased abundance of Testosterone] CTD PMID:6430271 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 affects response to substance ISO UGT1A3 affects the susceptibility to benoxaprofen CTD PMID:17880178 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 affects response to substance ISO UGT1A9 affects the susceptibility to benoxaprofen CTD PMID:17880178 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation
affects response to substance		 ISO UGT2B7 protein alternative form results in increased glucuronidation of benoxaprofen
UGT2B7 affects the susceptibility to benoxaprofen		 CTD PMID:8423545 PMID:17880178 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
chlorogenic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of ABCC1 protein] CTD PMID:25043994 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of ABCC2 protein] CTD PMID:25043994 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Ache acetylcholinesterase decreases activity ISO Chlorogenic Acid results in decreased activity of ACHE protein CTD PMID:20854806 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Acly ATP citrate lyase increases expression ISO Chlorogenic Acid results in increased expression of ACLY mRNA CTD PMID:20706672 NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] CTD PMID:23146752 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Alb albumin multiple interactions EXP
ISO		 Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of ALB protein]
Chlorogenic Acid affects the reaction [2,2'-azobis(2-amidinopropane) results in increased degradation of ALB protein]		 CTD PMID:11322927 PMID:23146752 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Aqp1 aquaporin 1 increases expression ISO Chlorogenic Acid results in increased expression of AQP1 mRNA CTD PMID:20706672 NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690 		JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) increases expression ISO Chlorogenic Acid results in increased expression of AQP3 mRNA CTD PMID:20706672 NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720 		JBrowse link
G Ar androgen receptor decreases expression ISO Chlorogenic Acid results in decreased expression of AR mRNA CTD PMID:20706672 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Atf4 activating transcription factor 4 multiple interactions EXP Chlorogenic Acid inhibits the reaction [Glucose results in increased expression of ATF4 protein] CTD PMID:34801538 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Atf6 activating transcription factor 6 multiple interactions EXP Chlorogenic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Fructose] results in increased expression of ATF6 protein]; Chlorogenic Acid inhibits the reaction [Glucose results in increased expression of ATF6 protein] CTD PMID:34801538 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G Bambi BMP and activin membrane-bound inhibitor multiple interactions EXP Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of BAMBI mRNA]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of BAMBI protein] CTD PMID:23146752 NCBI chr17:54,121,251...54,125,816
Ensembl chr17:54,121,255...54,126,060 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 ISO
EXP		 Chlorogenic Acid inhibits the reaction [Aluminum Chloride results in increased expression of BAX protein]; Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of BAX protein]; Chlorogenic Acid inhibits the reaction [sodium arsenite results in increased expression of BAX mRNA]
Chlorogenic Acid results in increased expression of BAX mRNA; Chlorogenic Acid results in increased expression of BAX protein
Chlorogenic Acid inhibits the reaction [Methotrexate results in increased expression of BAX protein]		 CTD PMID:25043994 PMID:28479099 PMID:28623112 PMID:33058431 PMID:33242462 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 EXP
ISO		 Chlorogenic Acid inhibits the reaction [Glucose results in decreased expression of BCL2 protein]; Chlorogenic Acid inhibits the reaction [Methotrexate results in decreased expression of BCL2 protein]
Chlorogenic Acid results in decreased expression of BCL2 mRNA; Chlorogenic Acid results in decreased expression of BCL2 protein
Chlorogenic Acid inhibits the reaction [Aluminum Chloride results in decreased expression of BCL2 protein]; Chlorogenic Acid inhibits the reaction [sodium arsenite results in decreased expression of BCL2 mRNA]		 CTD PMID:28479099 PMID:28623112 PMID:33058431 PMID:33242462 PMID:34801538 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Canx calnexin multiple interactions EXP Chlorogenic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Fructose] results in increased expression of CANX protein]; Chlorogenic Acid inhibits the reaction [Glucose results in increased expression of CANX protein] CTD PMID:34801538 NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821 		JBrowse link
G Casp12 caspase 12 multiple interactions EXP Chlorogenic Acid inhibits the reaction [Glucose results in increased expression of CASP12 protein] CTD PMID:34801538 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression		 ISO
EXP		 Chlorogenic Acid inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Chlorogenic Acid inhibits the reaction [sodium arsenite results in increased expression of CASP3 mRNA]; Chlorogenic Acid inhibits the reaction [sodium arsenite results in increased expression of CASP3 protein]
Chlorogenic Acid results in increased expression of CASP3 mRNA
Chlorogenic Acid inhibits the reaction [Glucose results in increased activity of CASP3 protein]; Chlorogenic Acid inhibits the reaction [Methotrexate results in increased activity of CASP3 protein]		 CTD PMID:25043994 PMID:28479099 PMID:33058431 PMID:33242462 PMID:34801538 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO Chlorogenic Acid inhibits the reaction [aluminum chloride results in increased expression of CASP8 protein] CTD PMID:28623112 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions EXP Chlorogenic Acid inhibits the reaction [Methotrexate results in increased activity of CASP9 protein] CTD PMID:28479099 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions EXP
ISO		 Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased activity of CAT protein]; Chlorogenic Acid inhibits the reaction [Methotrexate results in decreased activity of CAT protein]
Chlorogenic Acid inhibits the reaction [Aluminum Chloride results in decreased activity of CAT protein]; Chlorogenic Acid inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Chlorogenic Acid inhibits the reaction [sodium arsenite results in decreased expression of CAT mRNA]		 CTD PMID:28479099 PMID:28623112 PMID:31390532 PMID:33242462 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of CCL2 mRNA]; Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased secretion of CCL2 protein]; Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein] CTD PMID:26079055 PMID:31306686 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of CCND1 protein] CTD PMID:25043994 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cd44 CD44 molecule (Indian blood group) increases expression ISO Chlorogenic Acid results in increased expression of CD44 mRNA CTD PMID:20706672 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Cdh1 cadherin 1 increases expression ISO Chlorogenic Acid results in increased expression of CDH1 mRNA CTD PMID:20706672 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression
multiple interactions		 ISO
EXP		 Chlorogenic Acid results in increased expression of COL1A1 mRNA
Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]		 CTD PMID:20706672 PMID:23146752 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Amino Acids]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pantothenic Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of phenylpyruvic acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Allantoin]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Amino Acids]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Carnitine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Citric Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatinine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of phenylacetylglycine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Succinic Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uric Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uridine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased secretion of IL1B protein] CTD PMID:24709313 NCBI chr 7:129,098,489...129,127,620
Ensembl chr 7:129,098,786...129,127,546 		JBrowse link
G Cs citrate synthase increases activity ISO Chlorogenic Acid results in increased activity of CS protein CTD PMID:31306686 NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of CXCL1 mRNA]; Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased secretion of CXCL1 protein] CTD PMID:26079055 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Cygb cytoglobin decreases expression ISO Chlorogenic Acid results in decreased expression of CYGB mRNA CTD PMID:20706672 NCBI chr10:101,877,675...101,887,442
Ensembl chr10:101,877,676...101,887,442 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression EXP Chlorogenic Acid results in increased expression of CYP19A1 protein CTD PMID:29899696 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of CYP2E1 protein] CTD PMID:25043994 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions EXP Chlorogenic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Fructose] results in increased expression of DDIT3 protein]; Chlorogenic Acid inhibits the reaction [Glucose results in increased expression of DDIT3 protein] CTD PMID:34801538 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dsg3 desmoglein 3 decreases expression ISO Chlorogenic Acid results in decreased expression of DSG3 mRNA CTD PMID:20706672 NCBI chr18:11,798,905...11,833,415
Ensembl chr18:11,798,900...11,830,818 		JBrowse link
G Egf epidermal growth factor decreases expression ISO Chlorogenic Acid results in decreased expression of EGF mRNA CTD PMID:20706672 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions EXP Chlorogenic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Fructose] results in increased expression of EIF2AK3 protein]; Chlorogenic Acid inhibits the reaction [Glucose results in increased phosphorylation of EIF2AK3 protein] CTD PMID:34801538 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions EXP Chlorogenic Acid inhibits the reaction [Glucose results in increased phosphorylation of EIF2S1 protein] CTD PMID:34801538 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions EXP Chlorogenic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Fructose] results in increased expression of ERN1 protein]; Chlorogenic Acid inhibits the reaction [Glucose results in increased phosphorylation of ERN1 protein] CTD PMID:34801538 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha multiple interactions EXP Chlorogenic Acid inhibits the reaction [Glucose results in increased expression of ERO1A protein] CTD PMID:34801538 NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478 		JBrowse link
G Esr1 estrogen receptor 1 decreases expression EXP Chlorogenic Acid results in decreased expression of ESR1 protein CTD PMID:29899696 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 increases expression EXP Chlorogenic Acid results in increased expression of ESR2 protein CTD PMID:29899696 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G F10 coagulation factor X decreases activity ISO Chlorogenic Acid results in decreased activity of F10 protein CTD PMID:27704645 NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141 		JBrowse link
G F2 coagulation factor II decreases activity ISO Chlorogenic Acid results in decreased activity of F2 protein CTD PMID:27704645 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G Fasn fatty acid synthase decreases expression ISO Chlorogenic Acid results in decreased expression of FASN mRNA CTD PMID:21870829 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fbn1 fibrillin 1 decreases expression ISO Chlorogenic Acid results in decreased expression of FBN1 mRNA CTD PMID:20706672 NCBI chr 3:112,554,257...112,750,835
Ensembl chr 3:112,554,925...112,750,889 		JBrowse link
G Fbn2 fibrillin 2 decreases expression ISO Chlorogenic Acid results in decreased expression of FBN2 mRNA CTD PMID:20706672 NCBI chr18:51,499,737...51,703,976
Ensembl chr18:51,499,737...51,703,976 		JBrowse link
G Fgf1 fibroblast growth factor 1 increases expression ISO Chlorogenic Acid results in increased expression of FGF1 mRNA CTD PMID:20706672 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357 		JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO Chlorogenic Acid inhibits the reaction [sodium arsenite results in decreased expression of FSHB protein] CTD PMID:33242462 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Fshr follicle stimulating hormone receptor increases expression EXP Chlorogenic Acid results in increased expression of FSHR protein CTD PMID:29899696 NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions		 ISO Chlorogenic Acid results in increased expression of GCLC mRNA
Chlorogenic Acid promotes the reaction [Acetaminophen results in increased expression of GCLC mRNA]		 CTD PMID:29136249 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Chlorogenic Acid results in increased expression of GCLM mRNA CTD PMID:29136249 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
decreases expression		 EXP
ISO		 Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased activity of GPT protein]; Chlorogenic Acid inhibits the reaction [Methotrexate results in increased activity of GPT protein]
Chlorogenic Acid results in decreased expression of GPT protein
Chlorogenic Acid inhibits the reaction [aluminum chloride results in increased activity of GPT protein]		 CTD PMID:28479099 PMID:28623112 PMID:31390532 PMID:33058431 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO Chlorogenic Acid inhibits the reaction [sodium arsenite results in decreased expression of GPX1 mRNA] CTD PMID:33242462 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Grn granulin precursor increases expression ISO Chlorogenic Acid results in increased expression of GRN mRNA CTD PMID:20706672 NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP
ISO		 Chlorogenic Acid inhibits the reaction [Methotrexate results in decreased activity of GSR protein]
Chlorogenic Acid inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]; Chlorogenic Acid inhibits the reaction [sodium arsenite results in decreased expression of GSR mRNA]		 CTD PMID:28479099 PMID:33242462 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases activity ISO Chlorogenic Acid results in increased activity of GSTA1 protein CTD PMID:15944151 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472 		JBrowse link
G Has1 hyaluronan synthase 1 increases expression ISO Chlorogenic Acid results in increased expression of HAS1 mRNA CTD PMID:20706672 NCBI chr 1:58,693,411...58,705,653
Ensembl chr 1:58,693,411...58,705,397 		JBrowse link
G Hlcs holocarboxylase synthetase decreases activity ISO Chlorogenic Acid results in decreased activity of HLCS protein CTD PMID:26303405 NCBI chr11:33,455,806...33,635,197
Ensembl chr11:33,455,809...33,624,222 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases expression
multiple interactions		 ISO
EXP		 Chlorogenic Acid results in decreased expression of HMGCR mRNA
[tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein]; Chlorogenic Acid results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein]		 CTD PMID:20696151 PMID:21870829 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of HMOX1 protein]
Chlorogenic Acid results in increased expression of HMOX1 mRNA
Chlorogenic Acid inhibits the reaction [Acetaminophen results in decreased expression of HMOX1 mRNA]; Chlorogenic Acid inhibits the reaction [Acetaminophen results in decreased expression of HMOX1 protein]		 CTD PMID:25043994 PMID:29136249 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Chlorogenic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Fructose] results in increased expression of HSPA5 protein]; Chlorogenic Acid inhibits the reaction [Glucose results in increased expression of HSPA5 protein] CTD PMID:34801538 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression ISO Chlorogenic Acid results in increased expression of HSPB1 mRNA CTD PMID:20706672 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743 		JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO Chlorogenic Acid results in decreased expression of IL1A mRNA CTD PMID:20706672 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP
ISO		 [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased secretion of IL1B protein]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B mRNA]
Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of IL1B mRNA]; Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased secretion of IL1B protein]; Chlorogenic Acid inhibits the reaction [sodium arsenite results in increased expression of IL1B protein]		 CTD PMID:23146752 PMID:24709313 PMID:26079055 PMID:33242462 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions		 ISO
EXP		 Chlorogenic Acid results in increased expression of IL6 mRNA
Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of IL6 mRNA]; Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased secretion of IL6 protein]; Chlorogenic Acid inhibits the reaction [sodium arsenite results in increased expression of IL6 protein]
Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL6 protein]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]		 CTD PMID:21870829 PMID:23146752 PMID:26079055 PMID:31390532 PMID:33242462 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itgb2 integrin subunit beta 2 decreases expression
multiple interactions		 EXP Chlorogenic Acid results in decreased expression of ITGB2 protein
Chlorogenic Acid inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of ITGB2 protein]		 CTD PMID:21414398 NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of JUN protein] CTD PMID:15944151 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Krt5 keratin 5 increases expression ISO Chlorogenic Acid results in increased expression of KRT5 mRNA CTD PMID:20706672 NCBI chr 7:132,846,355...132,851,986
Ensembl chr 7:132,846,136...132,851,850 		JBrowse link
G Lcat lecithin cholesterol acyltransferase multiple interactions EXP [tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LCAT protein]; Chlorogenic Acid results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LCAT protein] CTD PMID:20696151 NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231 		JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions ISO Chlorogenic Acid inhibits the reaction [sodium arsenite results in decreased expression of LHB protein] CTD PMID:33242462 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Lpl lipoprotein lipase multiple interactions EXP [tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LPL protein]; Chlorogenic Acid results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LPL protein] CTD PMID:20696151 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249 		JBrowse link
G Maoa monoamine oxidase A decreases activity ISO Chlorogenic Acid results in decreased activity of MAOA protein CTD PMID:27270453 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593 		JBrowse link
G Maob monoamine oxidase B decreases activity ISO Chlorogenic Acid results in decreased activity of MAOB protein CTD PMID:27270453 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003 		JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAP2K4 protein] CTD PMID:15944151 NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]
Chlorogenic Acid promotes the reaction [Acetaminophen results in increased phosphorylation of MAPK1 protein]		 CTD PMID:15944151 PMID:29136249 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK14 protein] CTD PMID:15944151 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Chlorogenic Acid promotes the reaction [Acetaminophen results in increased phosphorylation of MAPK3 protein]
Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]		 CTD PMID:15944151 PMID:29136249 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP Chlorogenic Acid inhibits the reaction [Glucose results in increased phosphorylation of MAPK8 protein] CTD PMID:34801538 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mc1r melanocortin 1 receptor increases expression ISO Chlorogenic Acid results in increased expression of MC1R mRNA CTD PMID:20706672 NCBI chr19:51,452,448...51,455,375
Ensembl chr19:51,453,239...51,454,192 		JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 decreases activity EXP Chlorogenic Acid results in decreased activity of MGST1 protein CTD PMID:16125204 NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of MPO protein] CTD PMID:26079055 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I increases expression ISO Chlorogenic Acid results in increased expression of COX1 mRNA CTD PMID:20706672 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867 		JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II multiple interactions ISO [Chlorogenic Acid co-treated with Zymosan] results in decreased expression of COX2 protein; Chlorogenic Acid inhibits the reaction [Zymosan results in increased expression of COX2 protein] CTD PMID:30481570 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions EXP
ISO		 Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of MYD88 mRNA]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of MYD88 protein]
Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of MYD88 protein]		 CTD PMID:23146752 PMID:26079055 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases response to substance
multiple interactions
increases response to substance
affects localization
increases localization		 ISO NFE2L2 gene mutant form results in decreased susceptibility to Chlorogenic Acid
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Chlorogenic Acid co-treated with Acetaminophen] results in increased phosphorylation of and affects the localization of and results in increased activity of NFE2L2 protein]; [Chlorogenic Acid co-treated with Acetaminophen] results in increased activity of and affects the localization of NFE2L2 protein; [Chlorogenic Acid co-treated with Acetaminophen] results in increased phosphorylation of and affects the localization of and results in increased activity of NFE2L2 protein; U 0126 inhibits the reaction [[Chlorogenic Acid co-treated with Acetaminophen] results in increased phosphorylation of and affects the localization of and results in increased activity of NFE2L2 protein]
[Chlorogenic Acid co-treated with Acetaminophen] affects the localization of and results in increased activity of NFE2L2 protein; Chlorogenic Acid inhibits the reaction [sodium arsenite results in decreased expression of NFE2L2 mRNA]
NFE2L2 results in increased susceptibility to Chlorogenic Acid
Chlorogenic Acid affects the localization of NFE2L2 protein
Chlorogenic Acid results in increased localization of NFE2L2 protein		 CTD PMID:15944151 PMID:29136249 PMID:33242462 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO
EXP		 Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein]
Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of and results in increased phosphorylation of NFKBIA protein]		 CTD PMID:20026373 PMID:23146752 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nfkbib NFKB inhibitor beta multiple interactions ISO Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of NFKBIB protein] CTD PMID:20026373 NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP
ISO		 Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; Chlorogenic Acid inhibits the reaction [Methotrexate results in increased expression of NOS2 protein]
Chlorogenic Acid inhibits the reaction [[Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Chlorogenic Acid inhibits the reaction [sodium arsenite results in increased expression of NOS2 mRNA]; Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein]		 CTD PMID:20026373 PMID:23146752 PMID:28479099 PMID:31306686 PMID:33242462 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 increases expression ISO Chlorogenic Acid results in increased expression of NOS3 mRNA CTD PMID:20706672 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nppb natriuretic peptide B multiple interactions EXP Chlorogenic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Fructose] results in increased expression of NPPB protein] CTD PMID:34801538 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
increases activity		 ISO Chlorogenic Acid inhibits the reaction [Acetaminophen results in decreased expression of NQO1 mRNA]; Chlorogenic Acid inhibits the reaction [Acetaminophen results in decreased expression of NQO1 protein]
Chlorogenic Acid results in increased expression of NQO1 mRNA
Chlorogenic Acid results in increased activity of NQO1 protein		 CTD PMID:15944151 PMID:29136249 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Ocln occludin multiple interactions EXP Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of OCLN mRNA]; Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of OCLN protein] CTD PMID:31390532 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150 		JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta multiple interactions EXP Chlorogenic Acid inhibits the reaction [Glucose results in increased expression of P4HB protein] CTD PMID:34801538 NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO Chlorogenic Acid promotes the reaction [Cisplatin results in increased expression of PCNA protein] CTD PMID:25043994 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 multiple interactions EXP Chlorogenic Acid inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of PECAM1 protein] CTD PMID:21414398 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116 		JBrowse link
G Pgr progesterone receptor decreases expression
increases expression		 ISO Chlorogenic Acid results in decreased expression of PGR mRNA
Chlorogenic Acid results in increased expression of PGR mRNA		 CTD PMID:20706672 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 increases expression ISO Chlorogenic Acid results in increased expression of PIK3R1 mRNA CTD PMID:21870829 NCBI chr 2:32,878,942...32,963,611
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Plod3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 increases expression ISO Chlorogenic Acid results in increased expression of PLOD3 mRNA CTD PMID:20706672 NCBI chr12:19,676,384...19,686,945
Ensembl chr12:19,676,386...19,686,960 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
decreases expression		 ISO Chlorogenic Acid results in increased expression of PPARG mRNA
Chlorogenic Acid results in decreased expression of PPARG mRNA		 CTD PMID:20706672 PMID:21870829 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha multiple interactions ISO [Chlorogenic Acid co-treated with Acetaminophen] results in decreased expression of PPP2R1A protein CTD PMID:29136249 NCBI chr 1:60,540,223...60,559,467
Ensembl chr 1:60,540,194...60,560,129 		JBrowse link
G Ppp5c protein phosphatase 5, catalytic subunit multiple interactions ISO [Chlorogenic Acid co-treated with Acetaminophen] results in decreased expression of PPP5C protein CTD PMID:29136249 NCBI chr 1:77,690,203...77,714,507
Ensembl chr 1:77,690,208...77,714,456 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP		 Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of PTGS2 protein]; Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of and results in increased expression of PTGS2 protein]
Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 mRNA]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]; Chlorogenic Acid inhibits the reaction [Methotrexate results in increased expression of PTGS2 protein]		 CTD PMID:20026373 PMID:23146752 PMID:25043994 PMID:28479099 PMID:31306686 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rad23a RAD23 homolog A, nucleotide excision repair protein decreases expression ISO Chlorogenic Acid results in decreased expression of RAD23A mRNA CTD PMID:20706672 NCBI chr19:23,313,563...23,320,702
Ensembl chr19:23,314,797...23,320,695 		JBrowse link
G Rara retinoic acid receptor, alpha increases expression ISO Chlorogenic Acid results in increased expression of RARA mRNA CTD PMID:20706672 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of and results in increased phosphorylation of and affects the localization of RELA protein]; Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of RELA protein] CTD PMID:20026373 PMID:26079055 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Retreg1 reticulophagy regulator 1 multiple interactions EXP Chlorogenic Acid inhibits the reaction [Glucose results in decreased expression of RETREG1 protein] CTD PMID:34801538 NCBI chr 2:76,335,609...76,474,817
Ensembl chr 2:76,335,609...76,493,898 		JBrowse link
G Rtn3 reticulon 3 multiple interactions EXP Chlorogenic Acid inhibits the reaction [Glucose results in increased expression of RTN3 protein] CTD PMID:34801538 NCBI chr 1:204,612,675...204,669,212
Ensembl chr 1:204,612,675...204,669,275 		JBrowse link
G Rxra retinoid X receptor alpha decreases expression ISO Chlorogenic Acid results in decreased expression of RXRA mRNA CTD PMID:20706672 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712 		JBrowse link
G Sec62 SEC62 homolog, preprotein translocation factor multiple interactions EXP Chlorogenic Acid inhibits the reaction [Glucose results in increased expression of SEC62 protein] CTD PMID:34801538 NCBI chr 2:112,570,810...112,607,576
Ensembl chr 2:112,570,819...112,601,814 		JBrowse link
G Sell selectin L multiple interactions EXP [Chlorogenic Acid co-treated with lipopolysaccharide, E. coli O26-B6] results in increased expression of SELL protein; Chlorogenic Acid inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in decreased expression of SELL protein] CTD PMID:21414398 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456 		JBrowse link
G Slc11a2 solute carrier family 11 member 2 multiple interactions EXP Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SLC11A2 mRNA]; Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SLC11A2 protein] CTD PMID:31390532 NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Cisplatin results in decreased expression of SLC22A2 protein] CTD PMID:25043994 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression ISO Chlorogenic Acid results in increased expression of SLC2A4 mRNA CTD PMID:21870829 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression
multiple interactions		 ISO Chlorogenic Acid results in increased expression of SOD2 mRNA
Chlorogenic Acid inhibits the reaction [sodium arsenite results in decreased expression of SOD2 mRNA]		 CTD PMID:33242462 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sod3 superoxide dismutase 3 decreases expression ISO Chlorogenic Acid results in decreased expression of SOD3 mRNA CTD PMID:20706672 NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Acetaminophen results in decreased expression of SQSTM1 protein] CTD PMID:29136249 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 decreases expression ISO Chlorogenic Acid results in decreased expression of SRD5A2 mRNA CTD PMID:20706672 NCBI chr 6:21,426,225...21,465,727
Ensembl chr 6:21,426,215...21,462,112 		JBrowse link
G Star steroidogenic acute regulatory protein increases expression EXP Chlorogenic Acid results in increased expression of STAR protein CTD PMID:29899696 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Tjp1 tight junction protein 1 multiple interactions EXP Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of TJP1 mRNA]; Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of TJP1 protein] CTD PMID:31390532 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Tlr3 toll-like receptor 3 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of TLR3 protein] CTD PMID:26079055 NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP
ISO		 Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR4 mRNA]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR4 protein]
Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of TLR4 protein]		 CTD PMID:23146752 PMID:26079055 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 ISO
EXP		 Chlorogenic Acid results in increased expression of TNF mRNA
Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TNF protein]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]
Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of TNF mRNA]; Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased secretion of TNF protein]; Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of TNF protein]; Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Chlorogenic Acid inhibits the reaction [sodium arsenite results in increased expression of TNF protein]		 CTD PMID:21870829 PMID:23146752 PMID:25043994 PMID:26079055 PMID:31306686 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression		 ISO Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of TRP53 protein]
Chlorogenic Acid results in increased expression of TRP53 mRNA		 CTD PMID:25043994 PMID:33058431 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tpt1 tumor protein, translationally-controlled 1 increases expression ISO Chlorogenic Acid results in increased expression of TPT1 mRNA CTD PMID:20706672 NCBI chr15:51,156,728...51,159,629
Ensembl chr15:51,146,154...51,159,625 		JBrowse link
G Traf2 Tnf receptor-associated factor 2 multiple interactions EXP Chlorogenic Acid inhibits the reaction [Glucose results in increased expression of TRAF2 protein] CTD PMID:34801538 NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538 		JBrowse link
G Txn1 thioredoxin 1 increases expression ISO Chlorogenic Acid results in increased expression of TXN mRNA CTD PMID:20706672 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629 		JBrowse link
G Tyr tyrosinase increases oxidation
multiple interactions		 ISO TYR protein results in increased oxidation of Chlorogenic Acid
[TYR protein results in increased oxidation of Chlorogenic Acid] which results in decreased abundance of Glutathione		 CTD PMID:20685355 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207 		JBrowse link
G Tyrp1 tyrosinase-related protein 1 decreases expression ISO Chlorogenic Acid results in decreased expression of TYRP1 mRNA CTD PMID:20706672 NCBI chr 5:95,280,982...95,299,516
Ensembl chr 5:95,280,982...95,299,516 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Chlorogenic Acid CTD PMID:15117964 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions EXP Chlorogenic Acid inhibits the reaction [Glucose results in increased expression of XBP1 mRNA] CTD PMID:34801538 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
cis-caffeic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO caffeic acid results in increased phosphorylation of and results in decreased activity of ACACA protein CTD PMID:28576465 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457 		JBrowse link
G Ache acetylcholinesterase decreases activity
multiple interactions		 EXP caffeic acid results in decreased activity of ACHE protein
caffeic acid inhibits the reaction [Caffeine results in decreased activity of ACHE protein]; Caffeine promotes the reaction [caffeic acid results in decreased activity of ACHE protein]		 CTD PMID:28465162 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Acly ATP citrate lyase multiple interactions ISO [Metformin co-treated with caffeic acid] results in decreased expression of ACLY protein CTD PMID:28576465 NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase multiple interactions
decreases activity		 ISO [caffeic acid results in decreased activity of ALOX15 protein] inhibits the reaction [vorinostat results in increased activity of CASP3 protein]; [caffeic acid results in decreased activity of ALOX15 protein] which results in decreased chemical synthesis of 13-hydroxy-9,11-octadecadienoic acid; [caffeic acid results in decreased activity of ALOX15 protein] which results in increased abundance of 13-hydroxy-9,11-octadecadienoic acid; caffeic acid inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased activity of ALOX15 protein] CTD PMID:10904086 PMID:11406566 PMID:15574791 NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions EXP
ISO		 caffeic acid inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] affects the localization of ALOX5 protein]; caffeic acid inhibits the reaction [Aluminum results in increased expression of ALOX5 mRNA]; caffeic acid inhibits the reaction [Aluminum results in increased expression of ALOX5 protein]; caffeic acid inhibits the reaction [Hydrogen Peroxide affects the localization of ALOX5 protein]
caffeic acid inhibits the reaction [aluminum chloride results in increased expression of ALOX5 mRNA]; caffeic acid inhibits the reaction [aluminum chloride results in increased expression of ALOX5 protein]		 CTD PMID:18482095 PMID:18951527 PMID:27368151 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO caffeic acid inhibits the reaction [aluminum chloride results in increased expression of APP protein modified form]; caffeic acid inhibits the reaction [aluminum chloride results in increased expression of APP protein] CTD PMID:18482095 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Arg1 arginase 1 decreases activity ISO caffeic acid results in decreased activity of ARG1 protein CTD PMID:27378625 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422 		JBrowse link
G Atp6v0d2 ATPase H+ transporting V0 subunit D2 multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in decreased expression of ATP6V0D2 mRNA] CTD PMID:19442820 NCBI chr 5:33,336,257...33,385,354
Ensembl chr 5:33,336,264...33,385,354 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP		 [caffeic acid results in decreased activity of ALOX15 protein] inhibits the reaction [vorinostat results in increased activity of CASP3 protein]
caffeic acid inhibits the reaction [Valproic Acid results in increased expression of CASP3 protein]		 CTD PMID:15574791 PMID:29968957 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions
increases activity		 EXP
ISO		 caffeic acid inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; caffeic acid inhibits the reaction [Nickel results in decreased activity of CAT protein]
caffeic acid results in increased activity of CAT protein
caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate inhibits the reaction [CAT protein results in increased metabolism of Hydrogen Peroxide]]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of CAT protein]		 CTD PMID:18405891 PMID:21640567 PMID:22036979 PMID:27378625 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO [Resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCL2 mRNA; caffeic acid inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein] CTD PMID:16806235 PMID:31306686 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO [resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCL3 mRNA CTD PMID:16806235 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 multiple interactions ISO [resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCL4 mRNA CTD PMID:16806235 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231 		JBrowse link
G Ccr1 C-C motif chemokine receptor 1 multiple interactions ISO [resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCR1 mRNA CTD PMID:16806235 NCBI chr 8:123,556,286...123,561,841 JBrowse link
G Ccr2 C-C motif chemokine receptor 2 multiple interactions ISO [resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCR2 mRNA CTD PMID:16806235 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100 		JBrowse link
G Ccr4 C-C motif chemokine receptor 4 multiple interactions ISO [resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCR4 mRNA CTD PMID:16806235 NCBI chr 8:114,176,256...114,182,155
Ensembl chr 8:114,176,974...114,178,056 		JBrowse link
G Cd4 Cd4 molecule multiple interactions ISO [resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CD4 mRNA CTD PMID:16806235 NCBI chr 4:157,668,878...157,695,366 JBrowse link
G Cd68 Cd68 molecule multiple interactions ISO [resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CD68 mRNA CTD PMID:16806235 NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697 		JBrowse link
G Cdc20 cell division cycle 20 multiple interactions ISO [Thapsigargin co-treated with caffeic acid] results in increased expression of CDC20 mRNA CTD PMID:19442820 NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512 		JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in increased expression of CDK2 mRNA] CTD PMID:19442820 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Chat choline O-acetyltransferase multiple interactions ISO caffeic acid inhibits the reaction [aluminum chloride results in decreased expression of CHAT protein] CTD PMID:18482095 NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093 		JBrowse link
G Comt catechol-O-methyltransferase increases methylation ISO COMT protein results in increased methylation of caffeic acid CTD PMID:11160877 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Crh corticotropin releasing hormone multiple interactions EXP caffeic acid inhibits the reaction [Malathion results in decreased expression of CRH mRNA] CTD PMID:25404496 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919 		JBrowse link
G Ctf1 cardiotrophin 1 multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in decreased expression of CTF1 mRNA] CTD PMID:19442820 NCBI chr 1:182,328,035...182,336,346
Ensembl chr 1:182,328,090...182,333,335 		JBrowse link
G Ctsb cathepsin B multiple interactions EXP caffeic acid inhibits the reaction [Isoproterenol results in increased activity of CTSB protein] CTD PMID:20391626 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500 		JBrowse link
G Ctsd cathepsin D multiple interactions EXP caffeic acid inhibits the reaction [Isoproterenol affects the activity of CTSD protein] CTD PMID:20391626 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in decreased expression of CXCL2 mRNA] CTD PMID:19442820 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP caffeic acid inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine] CTD PMID:7710944 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Dap death-associated protein multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in decreased expression of DAP mRNA] CTD PMID:19442820 NCBI chr 2:82,199,206...82,251,771
Ensembl chr 2:82,199,280...82,251,752 		JBrowse link
G Dnajb11 DnaJ heat shock protein family (Hsp40) member B11 multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in decreased expression of DNAJB11 mRNA] CTD PMID:19442820 NCBI chr11:78,151,750...78,168,259
Ensembl chr11:78,150,429...78,180,407 		JBrowse link
G Dpysl4 dihydropyrimidinase-like 4 multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in increased expression of DPYSL4 mRNA] CTD PMID:19442820 NCBI chr 1:193,883,039...193,898,916
Ensembl chr 1:193,883,106...193,898,914 		JBrowse link
G Edn1 endothelin 1 multiple interactions ISO [resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of EDN1 mRNA CTD PMID:16806235 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Egr1 early growth response 1 multiple interactions ISO caffeic acid affects the reaction [Acetaminophen results in increased expression of and affects the localization of EGR1 protein]; caffeic acid inhibits the reaction [Acetaminophen results in increased expression of EGR1 mRNA] CTD PMID:27720869 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Elmo2 engulfment and cell motility 2 multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in decreased expression of ELMO2 mRNA] CTD PMID:19442820 NCBI chr 3:154,023,661...154,061,259
Ensembl chr 3:154,023,661...154,061,185 		JBrowse link
G Erf Ets2 repressor factor multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in increased expression of ERF mRNA] CTD PMID:19442820 NCBI chr 1:80,829,935...80,838,388
Ensembl chr 1:80,829,935...80,838,388 		JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO caffeic acid inhibits the reaction [Acetaminophen results in increased expression of F3 protein] CTD PMID:27720869 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Fasn fatty acid synthase decreases expression
multiple interactions		 ISO caffeic acid results in decreased expression of FASN mRNA
[Metformin co-treated with caffeic acid] results in decreased expression of FASN protein		 CTD PMID:21870829 PMID:28576465 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Flrt2 fibronectin leucine rich transmembrane protein 2 multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in decreased expression of FLRT2 mRNA] CTD PMID:19442820 NCBI chr 6:114,777,547...114,872,688
Ensembl chr 6:114,777,599...114,872,785 		JBrowse link
G Flt4 Fms related receptor tyrosine kinase 4 multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in decreased expression of FLT4 mRNA] CTD PMID:19442820 NCBI chr10:33,913,725...33,954,770
Ensembl chr10:33,913,608...33,954,770 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases activity ISO caffeic acid results in decreased activity of G6PD protein CTD PMID:25130191 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions ISO caffeic acid inhibits the reaction [Acetaminophen results in increased expression of GADD45A mRNA]; caffeic acid inhibits the reaction [Acetaminophen results in increased expression of GADD45A protein] CTD PMID:27720869 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Glb1 galactosidase, beta 1 multiple interactions EXP caffeic acid inhibits the reaction [Isoproterenol affects the activity of GLB1 protein] CTD PMID:20391626 NCBI chr 8:114,085,508...114,158,127
Ensembl chr 8:114,085,508...114,158,127 		JBrowse link
G Gls glutaminase increases expression ISO caffeic acid results in increased expression of GLS protein CTD PMID:28576465 NCBI chr 9:49,344,616...49,416,900
Ensembl chr 9:49,344,781...49,416,900 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 multiple interactions EXP caffeic acid inhibits the reaction [tert-Butylhydroperoxide results in increased activity of GOT1 protein] CTD PMID:15212457 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP
ISO		 caffeic acid inhibits the reaction [tert-Butylhydroperoxide results in increased activity of GPT protein]
caffeic acid inhibits the reaction [Acetaminophen results in increased activity of GPT protein]		 CTD PMID:15212457 PMID:27720869 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP
ISO		 caffeic acid inhibits the reaction [Cisplatin results in decreased activity of GSR protein]
caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate inhibits the reaction [GSR protein results in increased oxidation of NADP]]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of GSR protein]
caffeic acid promotes the reaction [Thapsigargin results in decreased expression of GSR mRNA]		 CTD PMID:19442820 PMID:21640567 PMID:22036979 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases activity EXP caffeic acid results in decreased activity of GSTM1 protein CTD PMID:8340025 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 decreases activity EXP caffeic acid results in decreased activity of GSTM2 protein CTD PMID:8340025 NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases activity EXP caffeic acid results in decreased activity of GSTP1 protein CTD PMID:8340025 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Gusb glucuronidase, beta multiple interactions EXP caffeic acid inhibits the reaction [Isoproterenol results in increased activity of GUSB protein] CTD PMID:20391626 NCBI chr12:26,701,191...26,714,718
Ensembl chr12:26,697,951...26,726,905 		JBrowse link
G H6pd hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) multiple interactions EXP caffeic acid inhibits the reaction [Cisplatin results in decreased activity of H6PD protein] CTD PMID:21640567 NCBI chr 5:160,434,499...160,470,203
Ensembl chr 5:160,438,697...160,470,171 		JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 multiple interactions ISO [resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of HAVCR2 mRNA CTD PMID:16806235 NCBI chr10:30,882,484...30,914,018
Ensembl chr10:30,882,606...30,909,137 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 multiple interactions EXP caffeic acid inhibits the reaction [Valproic Acid results in increased expression of HES1 mRNA] CTD PMID:29968957 NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192 		JBrowse link
G Hlcs holocarboxylase synthetase decreases activity ISO caffeic acid results in decreased activity of HLCS protein CTD PMID:26303405 NCBI chr11:33,455,806...33,635,197
Ensembl chr11:33,455,809...33,624,222 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases expression ISO caffeic acid results in decreased expression of HMGCR mRNA CTD PMID:21870829 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in decreased expression of HSP90B1 mRNA] CTD PMID:19442820 NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788 		JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in increased expression of HSPE1 mRNA] CTD PMID:19442820 NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089 		JBrowse link
G Ifng interferon gamma increases expression
multiple interactions		 ISO
EXP		 caffeic acid results in increased expression of IFNG protein
caffeic acid inhibits the reaction [Valproic Acid results in increased expression of IFNG protein]		 CTD PMID:27378625 PMID:29968957 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 decreases expression ISO caffeic acid results in decreased expression of IL10 protein CTD PMID:27378625 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP		 caffeic acid inhibits the reaction [Acetaminophen results in increased expression of IL1B protein]
caffeic acid inhibits the reaction [Aluminum results in increased expression of IL1B protein]		 CTD PMID:27368151 PMID:27720869 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 increases expression ISO caffeic acid results in increased expression of IL2 protein CTD PMID:27378625 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il21r interleukin 21 receptor multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in decreased expression of IL21R mRNA] CTD PMID:19442820 NCBI chr 1:180,168,028...180,195,690
Ensembl chr 1:180,168,097...180,195,522 		JBrowse link
G Il4 interleukin 4 decreases expression ISO caffeic acid results in decreased expression of IL4 protein CTD PMID:27378625 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions		 ISO
EXP		 caffeic acid results in increased expression of IL6 mRNA
caffeic acid inhibits the reaction [Aluminum results in increased expression of IL6 protein]
caffeic acid inhibits the reaction [Acetaminophen results in increased expression of IL6 protein]		 CTD PMID:21870829 PMID:27368151 PMID:27720869 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Kif15 kinesin family member 15 multiple interactions ISO [Thapsigargin co-treated with caffeic acid] results in increased expression of KIF15 mRNA CTD PMID:19442820 NCBI chr 8:122,601,888...122,672,750
Ensembl chr 8:122,601,897...122,672,750 		JBrowse link
G Kif20b kinesin family member 20B multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in increased expression of KIF20B mRNA] CTD PMID:19442820 NCBI chr 1:232,428,293...232,483,798
Ensembl chr 1:232,428,371...232,483,787 		JBrowse link
G Kif2c kinesin family member 2C multiple interactions ISO caffeic acid inhibits the reaction [Thapsigargin results in increased expression of KIF2C mRNA] CTD PMID:19442820 NCBI chr 5:130,637,347...130,662,680
Ensembl chr 5:130,637,347...130,662,637 		JBrowse link
G Ldha lactate dehydrogenase A multiple interactions EXP caffeic acid inhibits the reaction [Isoproterenol results in increased expression of LDHA protein] CTD PMID:21472895 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Ldhb lactate dehydrogenase B multiple interactions EXP caffeic acid inhibits the reaction [Isoproterenol results in increased expression of LDHB protein] CTD PMID:21472895 NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403 		JBrowse link
G Maoa monoamine oxidase A decreases activity ISO caffeic acid results in decreased activity of MAOA protein CTD PMID:27270453 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593 		JBrowse link
G Maob monoamine oxidase B decreases activity ISO caffeic acid results in decreased activity of MAOB protein CTD PMID:27270453 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003 		JBrowse link
G Map2k5 mitogen activated protein kinase kinase 5 multiple interactions ISO [Thapsigargin co-treated with caffeic acid] results in decreased expression of MAP2K5 mRNA CTD PMID:19442820 NCBI chr 8:63,625,220...63,852,090
Ensembl chr 8:63,625,221...63,851,983 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO caffeic acid inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK1 protein] CTD PMID:27720869 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO caffeic acid inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK3 protein] CTD PMID:27720869 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mfn1 mitofusin 1 multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in decreased expression of MFN1 mRNA] CTD PMID:19442820 NCBI chr 2:115,313,380...115,359,651
Ensembl chr 2:115,313,401...115,359,640 		JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 increases activity EXP caffeic acid results in increased activity of MGST1 protein CTD PMID:16125204 NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892 		JBrowse link
G Mpo myeloperoxidase multiple interactions
decreases activity		 ISO
EXP		 caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [MPO protein results in increased metabolism of Hydrogen Peroxide]]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MPO protein]
caffeic acid inhibits the reaction [Ethanol results in increased activity of MPO protein]; NG-Nitroarginine Methyl Ester inhibits the reaction [caffeic acid inhibits the reaction [Ethanol results in increased activity of MPO protein]]
caffeic acid results in decreased activity of MPO protein		 CTD PMID:22036979 PMID:24060682 PMID:33301711 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mrpl45 mitochondrial ribosomal protein L45 multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in decreased expression of MRPL45 mRNA] CTD PMID:19442820 NCBI chr10:82,308,650...82,320,474
Ensembl chr10:82,308,427...82,320,474 		JBrowse link
G Mrrf mitochondrial ribosome recycling factor multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in decreased expression of MRRF mRNA] CTD PMID:19442820 NCBI chr 3:19,487,124...19,543,911
Ensembl chr 3:19,487,182...19,543,908 		JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II multiple interactions ISO [caffeic acid co-treated with Zymosan] results in increased expression of COX2 protein; caffeic acid inhibits the reaction [Zymosan results in increased expression of COX2 protein] CTD PMID:30481570 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689 		JBrowse link
G Ndp norrin cystine knot growth factor NDP increases expression ISO caffeic acid results in increased expression of NDP mRNA CTD PMID:19442820 NCBI chr  X:5,796,487...5,820,934
Ensembl chr  X:5,796,487...5,820,934 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP		 caffeic acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
caffeic acid inhibits the reaction [Valproic Acid results in increased expression of NOS2 protein]		 CTD PMID:29968957 PMID:31306686 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 increases expression ISO caffeic acid results in increased expression of NOS3 mRNA CTD PMID:15740983 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Notch1 notch receptor 1 multiple interactions EXP caffeic acid inhibits the reaction [Valproic Acid results in increased expression of NOTCH1 mRNA] CTD PMID:29968957 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Nt5e 5' nucleotidase, ecto multiple interactions
decreases activity		 EXP caffeic acid inhibits the reaction [Caffeine results in decreased activity of NT5E protein]; Caffeine promotes the reaction [caffeic acid results in decreased activity of NT5E protein] CTD PMID:28465162 NCBI chr 8:89,271,046...89,314,918
Ensembl chr 8:89,270,696...89,314,881 		JBrowse link
G Pdcd10 programmed cell death 10 multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in decreased expression of PDCD10 mRNA] CTD PMID:19442820 NCBI chr 2:160,303,465...160,346,086
Ensembl chr 2:160,303,449...160,346,018 		JBrowse link
G Pgd phosphogluconate dehydrogenase decreases activity ISO caffeic acid results in decreased activity of PGD protein CTD PMID:25130191 NCBI chr 5:159,582,746...159,598,945
Ensembl chr 5:159,561,271...159,742,778 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 increases expression ISO caffeic acid results in increased expression of PIK3R1 mRNA CTD PMID:21870829 NCBI chr 2:32,878,942...32,963,611
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Plk1 polo-like kinase 1 multiple interactions ISO [Thapsigargin co-treated with caffeic acid] results in increased expression of PLK1 mRNA CTD PMID:19442820 NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400 		JBrowse link
G Plk4 polo-like kinase 4 multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in increased expression of PLK4 mRNA] CTD PMID:19442820 NCBI chr 2:123,802,512...123,820,942
Ensembl chr 2:123,802,512...123,820,942 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression ISO caffeic acid results in increased expression of PPARG mRNA CTD PMID:21870829 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Prdx5 peroxiredoxin 5 multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in decreased expression of PRDX5 mRNA] CTD PMID:19442820 NCBI chr 1:204,099,826...204,103,589
Ensembl chr 1:204,099,826...204,114,268 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO caffeic acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]
caffeic acid promotes the reaction [Thapsigargin results in decreased expression of PTGS2 mRNA]		 CTD PMID:19442820 PMID:22036979 PMID:31306686 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptx3 pentraxin 3 multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in decreased expression of PTX3 mRNA] CTD PMID:19442820 NCBI chr 2:150,487,513...150,493,323
Ensembl chr 2:150,487,513...150,493,323 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO caffeic acid inhibits the reaction [Acetaminophen results in increased phosphorylation of RAF1 protein] CTD PMID:27720869 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP caffeic acid inhibits the reaction [Valproic Acid results in increased expression of RELA protein] CTD PMID:29968957 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO [Metformin co-treated with caffeic acid] results in decreased expression of SCD1 protein CTD PMID:28576465 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO caffeic acid inhibits the reaction [Acetaminophen results in increased expression of SERPINE1 protein] CTD PMID:27720869 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Sfxn4 sideroflexin 4 multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in decreased expression of SFXN4 mRNA] CTD PMID:19442820 NCBI chr 1:259,976,480...259,998,778
Ensembl chr 1:259,976,481...259,998,754 		JBrowse link
G Slc2a2 solute carrier family 2 member 2 increases expression ISO caffeic acid results in increased expression of SLC2A2 mRNA CTD PMID:33493636 NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression ISO caffeic acid results in increased expression of SLC2A4 mRNA CTD PMID:21870829 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Slc5a1 solute carrier family 5 member 1 increases expression ISO caffeic acid results in increased expression of SLC5A1 mRNA CTD PMID:33493636 NCBI chr14:77,553,990...77,618,589
Ensembl chr14:77,553,843...77,618,547 		JBrowse link
G Snca synuclein alpha multiple interactions ISO caffeic acid inhibits the reaction [SNCA protein binds to SNCA protein] CTD PMID:20150427 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO [Metformin co-treated with caffeic acid] results in decreased expression of SREBF1 protein CTD PMID:28576465 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Stk32a serine/threonine kinase 32A multiple interactions ISO [Thapsigargin co-treated with caffeic acid] results in decreased expression of STK32A mRNA CTD PMID:19442820 NCBI chr18:35,258,865...35,374,985
Ensembl chr18:35,259,052...35,369,451 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases sulfation ISO SULT1A1 protein results in increased sulfation of caffeic acid CTD PMID:17433394 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
G Sult1c2a sulfotransferase family 1C member 2A increases sulfation ISO SULT1C2 protein results in increased sulfation of caffeic acid CTD PMID:17433394 NCBI chr 9:6,873,697...6,904,736
Ensembl chr 9:6,874,249...6,904,734 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 ISO
EXP		 caffeic acid results in increased expression of TNF mRNA
caffeic acid inhibits the reaction [Aluminum results in increased expression of TNF protein]; caffeic acid inhibits the reaction [Valproic Acid results in increased expression of TNF protein]
caffeic acid inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TNF protein]		 CTD PMID:21870829 PMID:22036979 PMID:27368151 PMID:29968957 PMID:31306686 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 affects expression
multiple interactions		 ISO caffeic acid affects the expression of TP53 protein
caffeic acid promotes the reaction [Thapsigargin results in decreased expression of TP53 mRNA]		 CTD PMID:11522280 PMID:19442820 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tyr tyrosinase increases oxidation
multiple interactions		 ISO TYR protein results in increased oxidation of caffeic acid
[TYR protein results in increased oxidation of caffeic acid] which results in decreased abundance of Glutathione		 CTD PMID:20685355 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207 		JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in increased expression of UBE2C mRNA] CTD PMID:19442820 NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of caffeic acid CTD PMID:15117964 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases secretion ISO caffeic acid results in decreased secretion of VEGFA protein CTD PMID:27378625 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Xdh xanthine dehydrogenase multiple interactions ISO caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [XDH protein results in increased chemical synthesis of Uric Acid]]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of XDH protein] CTD PMID:22036979 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
docebenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox12 arachidonate 12-lipoxygenase, 12S type decreases activity ISO 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in decreased activity of ALOX12 protein CTD PMID:23238474 NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase decreases activity ISO
EXP		 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in decreased activity of ALOX5 protein CTD PMID:2724698 PMID:7812673 PMID:25432964 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]]
2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in increased activity of CASP3 protein		 CTD PMID:22308955 PMID:25432964 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP8 protein]] CTD PMID:25432964 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 increases activity
multiple interactions		 ISO 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in increased activity of HSD11B2 protein
[2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone co-treated with Leukotriene B4] results in decreased expression of HSD11B2 protein; Leukotriene B4 inhibits the reaction [2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in increased activity of HSD11B2 protein]		 CTD PMID:18032417 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899 		JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression		 ISO [2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone co-treated with 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide] results in decreased expression of IL6 mRNA
2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in decreased expression of IL6 mRNA		 CTD PMID:17766677 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MPO protein] CTD PMID:7812673 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Osmr oncostatin M receptor multiple interactions ISO 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of OSMR mRNA]] CTD PMID:25432964 NCBI chr 2:55,907,119...55,961,373
Ensembl chr 2:55,907,132...55,961,262 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions ISO 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of OSMR mRNA]]; 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of STAT3 protein]]; 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]]; 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP8 protein]]; 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of TNF protein]] CTD PMID:25432964 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [acenaphthenequinone results in increased expression of RELA protein] CTD PMID:17925309 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [Arachidonic Acid results in decreased activity of SOD1 protein] CTD PMID:16982041 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [Arachidonic Acid results in increased activity of SOD2 protein] CTD PMID:16982041 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of STAT3 protein]] CTD PMID:25432964 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [endotoxin, Escherichia coli results in increased secretion of TNF protein]; 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of TNF protein]]; 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone promotes the reaction [endotoxin, Escherichia coli results in increased expression of TNF mRNA]; 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in increased stability of and affects the expression of TNF mRNA CTD PMID:15060681 PMID:25432964 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 decreases activity ISO 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in decreased activity of TRPC6 protein CTD PMID:22308955 NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092 		JBrowse link
E3040 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO [SLCO1B1 protein co-treated with ABCC2 protein] results in increased transport of E 3040 analog CTD PMID:19628752 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 affects export ISO ABCG2 protein affects the export of E 3040 analog CTD PMID:15598971 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions ISO E 3040 inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid] CTD PMID:21272127 NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555 		JBrowse link
ebselen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO ebselen inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:16757516 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Adam9 ADAM metallopeptidase domain 9 multiple interactions ISO ebselen inhibits the reaction [Hydrogen Peroxide results in increased expression of ADAM9 protein] CTD PMID:17018608 NCBI chr16:67,022,538...67,101,647
Ensembl chr16:67,022,655...67,100,917 		JBrowse link
G Afp alpha-fetoprotein multiple interactions EXP ebselen inhibits the reaction [Aflatoxin B1 results in increased expression of AFP mRNA] CTD PMID:11133813 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480 		JBrowse link
G Alad aminolevulinate dehydratase decreases activity
multiple interactions		 EXP
ISO		 ebselen results in decreased activity of ALAD protein
ebselen inhibits the reaction [Cadmium Chloride results in decreased activity of ALAD protein]
Dithiothreitol inhibits the reaction [ebselen results in decreased activity of ALAD protein]		 CTD PMID:14630126 PMID:17624921 PMID:23933410 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase decreases activity ISO ebselen results in decreased activity of ALOX5 protein CTD PMID:7590103 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP ebselen inhibits the reaction [sodium arsenite results in increased expression of BAX protein] CTD PMID:30558456 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP ebselen inhibits the reaction [sodium arsenite results in decreased expression of BCL2 protein] CTD PMID:30558456 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO
EXP		 ebselen inhibits the reaction [Mechlorethamine results in increased activity of CASP3 protein]
ebselen results in increased activity of CASP3 protein
ebselen inhibits the reaction [Methylmercury Compounds results in increased activity of CASP3 protein]; ebselen inhibits the reaction [sodium arsenite results in increased expression of CASP3 protein]		 CTD PMID:21300091 PMID:23649643 PMID:25068500 PMID:30558456 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 multiple interactions EXP
ISO		 ebselen inhibits the reaction [Cadmium Chloride results in increased activity of CASP9 protein]
ebselen inhibits the reaction [Mechlorethamine results in increased activity of CASP9 protein]		 CTD PMID:18629305 PMID:23649643 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase increases activity
multiple interactions		 EXP ebselen results in increased activity of CAT protein
ebselen inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]		 CTD PMID:27282967 PMID:30558456 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4i1 increases expression ISO ebselen results in increased expression of COX4I1 protein CTD PMID:27385396 NCBI chr19:48,721,680...48,727,920
Ensembl chr19:48,721,199...48,727,921 		JBrowse link
G Cs citrate synthase multiple interactions ISO
EXP		 ebselen inhibits the reaction [FMR1 5' UTR mutant form results in decreased activity of CS protein]
ebselen inhibits the reaction [Cisplatin results in decreased activity of CS protein]		 CTD PMID:27385396 PMID:32860823 NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP ebselen inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 mRNA] CTD PMID:11903743 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation EXP ebselen results in increased phosphorylation of EIF2S1 protein CTD PMID:27282967 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Ephx2 epoxide hydrolase 2 multiple interactions ISO ebselen binds to and results in decreased activity of EPHX2 protein CTD PMID:23219563 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615 		JBrowse link
G Fmr1 fragile X messenger ribonucleoprotein 1 multiple interactions ISO ebselen inhibits the reaction [FMR1 5' UTR mutant form results in decreased activity of CS protein] CTD PMID:27385396 NCBI chr  X:147,240,239...147,278,057
Ensembl chr  X:147,240,301...147,278,050 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO ebselen inhibits the reaction [Lipopolysaccharides affects the localization of and affects the activity of FOS protein]; ebselen inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of FOS protein] CTD PMID:14572605 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions EXP ebselen inhibits the reaction [Cisplatin results in increased activity of G6PC1 protein] CTD PMID:32860823 NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804 		JBrowse link
G Gck glucokinase multiple interactions ISO [ebselen co-treated with Glucose] results in increased activity of GCK protein CTD PMID:23795780 NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995 		JBrowse link
G Gfap glial fibrillary acidic protein increases phosphorylation EXP ebselen results in increased phosphorylation of GFAP protein CTD PMID:27282967 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP ebselen inhibits the reaction [Oxygen deficiency results in increased expression of GJA1 mRNA]; ebselen inhibits the reaction [Oxygen deficiency results in increased expression of GJA1 protein] CTD PMID:12958040 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO ebselen inhibits the reaction [GPX1 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]]
ebselen inhibits the reaction [Methylmercury Compounds results in decreased activity of GPX1 protein]		 CTD PMID:23795780 PMID:28383113 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gsr glutathione-disulfide reductase increases activity
multiple interactions		 EXP ebselen results in increased activity of GSR protein
ebselen inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]		 CTD PMID:27282967 PMID:30558456 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions EXP ebselen binds to and results in decreased activity of [GSTA1 protein binds to GSTA3 protein] CTD PMID:8147899 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121 		JBrowse link
G Gsta3 glutathione S-transferase alpha 3 multiple interactions EXP ebselen binds to and results in decreased activity of [GSTA1 protein binds to GSTA3 protein]; ebselen binds to and results in decreased activity of GSTA3 protein CTD PMID:8147899 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions EXP ebselen binds to and results in decreased activity of [GSTM1 protein binds to GSTM2 protein] CTD PMID:8147899 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 multiple interactions EXP ebselen binds to and results in decreased activity of [GSTM1 protein binds to GSTM2 protein] CTD PMID:8147899 NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions EXP ebselen binds to and results in decreased activity of GSTP1 protein CTD PMID:8147899 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO ebselen inhibits the reaction [Acetylcysteine inhibits the reaction [Oxygen deficiency results in increased activity of HIF1A protein]]; ebselen inhibits the reaction [Acetylcysteine inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA]]; ebselen inhibits the reaction [glutathione glycylethyl ester inhibits the reaction [Oxygen deficiency results in increased activity of HIF1A protein]]; ebselen inhibits the reaction [glutathione glycylethyl ester inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA]] CTD PMID:19374849 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP [ebselen affects the abundance of Reactive Oxygen Species] which results in decreased expression of HMOX1 protein; [ebselen affects the abundance of Reactive Oxygen Species] which results in increased activity of HMOX1 protein CTD PMID:16959961 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hpgds hematopoietic prostaglandin D synthase increases expression ISO ebselen results in increased expression of HPGDS mRNA CTD PMID:21669866 NCBI chr 4:94,368,426...94,397,931
Ensembl chr 4:94,373,342...94,397,883 		JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO ebselen results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Ifng interferon gamma multiple interactions ISO ebselen inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; ebselen inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein] CTD PMID:12794164 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP ebselen inhibits the reaction [sodium arsenite results in increased expression of IL6 protein] CTD PMID:30558456 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
increases activity		 EXP
ISO		 ebselen analog results in increased phosphorylation of MAPK1 protein; ebselen results in increased phosphorylation of MAPK1 protein
ebselen inhibits the reaction [NGF protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]
ebselen results in increased activity of MAPK1 protein
ebselen inhibits the reaction [Methylmercury Compounds results in increased phosphorylation of MAPK1 protein]; ebselen inhibits the reaction [SOD2 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; ebselen inhibits the reaction [tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex results in increased phosphorylation of and results in increased activity of MAPK1 protein]		 CTD PMID:20495008 PMID:21300091 PMID:21960664 PMID:22001386 PMID:27282967 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases activity
increases phosphorylation		 ISO
EXP		 ebselen inhibits the reaction [NGF protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]
ebselen results in increased activity of MAPK3 protein
ebselen analog results in increased phosphorylation of MAPK3 protein; ebselen results in increased phosphorylation of MAPK3 protein
ebselen inhibits the reaction [Methylmercury Compounds results in increased phosphorylation of MAPK3 protein]; ebselen inhibits the reaction [SOD2 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; ebselen inhibits the reaction [tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex results in increased phosphorylation of and results in increased activity of MAPK3 protein]		 CTD PMID:20495008 PMID:21300091 PMID:21960664 PMID:22001386 PMID:27282967 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation EXP ebselen results in increased phosphorylation of MAPK9 protein CTD PMID:27282967 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions EXP ebselen inhibits the reaction [Carbon Tetrachloride results in decreased expression of MMP13 mRNA] CTD PMID:11903743 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239 		JBrowse link
G Ngf nerve growth factor multiple interactions ISO ebselen inhibits the reaction [NGF protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; ebselen inhibits the reaction [NGF protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:20495008 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Nos2 nitric oxide synthase 2 decreases activity
multiple interactions		 EXP
ISO		 ebselen results in decreased activity of NOS2 protein
ebselen inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; ebselen inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]		 CTD PMID:7590103 PMID:12794164 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 decreases activity EXP ebselen results in decreased activity of NQO1 protein CTD PMID:7590103 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 multiple interactions ISO [ebselen co-treated with Glucose] results in increased expression of PDX1 protein CTD PMID:23795780 NCBI chr12:7,757,865...7,763,064
Ensembl chr12:7,757,865...7,763,064 		JBrowse link
G Phospho1 phosphoethanolamine/phosphocholine phosphatase 1 decreases activity ISO ebselen results in decreased activity of PHOSPHO1 protein CTD PMID:17227223 NCBI chr10:80,762,062...80,769,596
Ensembl chr10:80,760,792...80,770,342 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO ebselen inhibits the reaction [Lipopolysaccharides affects the localization of and affects the activity of RELA protein]; ebselen inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of RELA protein] CTD PMID:14572605 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Slc11a2 solute carrier family 11 member 2 multiple interactions ISO ebselen inhibits the reaction [SLC11A2 protein results in increased uptake of Iron] CTD PMID:16984886 NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145 		JBrowse link
G Slc2a2 solute carrier family 2 member 2 multiple interactions ISO
EXP		 [ebselen co-treated with Glucose] results in increased expression of SLC2A2 protein
ebselen inhibits the reaction [Cisplatin results in increased expression of SLC2A2 protein]		 CTD PMID:23795780 PMID:32860823 NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO ebselen inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:21131394 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Sod1 superoxide dismutase 1 decreases response to substance
multiple interactions		 ISO ebselen results in decreased susceptibility to SOD1 protein mutant form
ebselen inhibits the reaction [SOD1 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]]		 CTD PMID:16702190 PMID:23795780 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP ebselen inhibits the reaction [SOD2 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; ebselen inhibits the reaction [SOD2 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:20495008 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Tat tyrosine aminotransferase multiple interactions EXP ebselen inhibits the reaction [Cisplatin results in increased activity of TAT protein] CTD PMID:32860823 NCBI chr19:37,947,153...37,957,717
Ensembl chr19:37,947,112...37,958,031 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO
EXP		 ebselen inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; ebselen inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]
ebselen inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]		 CTD PMID:11903743 PMID:16757516 PMID:21131394 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP ebselen inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 mRNA] CTD PMID:11903743 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP ebselen inhibits the reaction [sodium arsenite results in increased expression of TNF protein] CTD PMID:30558456 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions ISO ebselen results in increased expression of and results in increased activity of TXNRD1 protein CTD PMID:28383113 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions ISO [ebselen co-treated with Glucose] results in decreased expression of UCP2 protein CTD PMID:23795780 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611 		JBrowse link
G Xbp1 X-box binding protein 1 increases phosphorylation EXP ebselen results in increased phosphorylation of XBP1 protein CTD PMID:27282967 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
G Xpa XPA, DNA damage recognition and repair factor multiple interactions ISO ebselen inhibits the reaction [Zinc binds to XPA protein] CTD PMID:15265038 NCBI chr 5:60,431,673...60,476,438
Ensembl chr 5:60,431,673...60,475,726 		JBrowse link
ethyl trans-caffeate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO ethyl caffeate affects the phosphorylation of and affects the activity of AKT1 protein CTD PMID:24892518 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Cdh2 cadherin 2 affects expression ISO ethyl caffeate affects the expression of CDH2 protein CTD PMID:24892518 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Cdk2 cyclin dependent kinase 2 affects expression ISO ethyl caffeate affects the expression of CDK2 protein CTD PMID:24892518 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 affects expression ISO ethyl caffeate affects the expression of CDK4 protein CTD PMID:24892518 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 affects expression
multiple interactions		 ISO ethyl caffeate affects the expression of ERBB2 protein
ethyl caffeate affects the phosphorylation of and affects the activity of ERBB2 protein		 CTD PMID:24892518 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 affects expression ISO ethyl caffeate affects the expression of FGFR1 protein CTD PMID:24892518 NCBI chr16:66,492,445...66,546,731
Ensembl chr16:66,494,042...66,547,350 		JBrowse link
G Ilk integrin-linked kinase affects expression ISO ethyl caffeate affects the expression of ILK protein CTD PMID:24892518 NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140 		JBrowse link
G Itga3 integrin subunit alpha 3 multiple interactions ISO ethyl caffeate affects the expression of [ITGA3 protein binds to ITGB1 protein] CTD PMID:24892518 NCBI chr10:79,990,160...80,022,206
Ensembl chr10:79,990,161...80,022,118 		JBrowse link
G Itgb1 integrin subunit beta 1 multiple interactions ISO ethyl caffeate affects the expression of [ITGA3 protein binds to ITGB1 protein] CTD PMID:24892518 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195 		JBrowse link
G Kdr kinase insert domain receptor affects expression ISO ethyl caffeate affects the expression of KDR protein CTD PMID:24892518 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO ethyl caffeate affects the phosphorylation of and affects the activity of MAPK1 protein CTD PMID:24892518 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO ethyl caffeate affects the phosphorylation of and affects the activity of MAPK3 protein CTD PMID:24892518 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Rb1 RB transcriptional corepressor 1 affects phosphorylation ISO ethyl caffeate affects the phosphorylation of RB1 protein CTD PMID:24892518 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
eupatilin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CCL2 mRNA] CTD PMID:21565208 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases activity		 ISO [[eupatilin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [eupatilin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam CTD PMID:31756459 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL1B mRNA] CTD PMID:21565208 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 mRNA] CTD PMID:21565208 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:21565208 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of NOS2 mRNA]; eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of NOS2 protein] CTD PMID:21565208 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of PTGS2 mRNA]; eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of PTGS2 protein] CTD PMID:21565208 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 affects the localization of RELA protein] CTD PMID:21565208 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF mRNA] CTD PMID:21565208 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
ginkgetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO ginkgetin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]
ginkgetin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BAX protein]		 CTD PMID:25968939 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO ginkgetin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]
ginkgetin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of BCL2 protein]		 CTD PMID:25968939 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO ginkgetin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased cleavage of CASP3 protein] CTD PMID:25968939 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ftl1 ferritin light chain 1 decreases expression ISO ginkgetin results in decreased expression of FTL protein
ginkgetin results in decreased expression of FTL1 protein		 CTD PMID:25968939 NCBI chr 1:95,936,390...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725 		JBrowse link
G Tfrc transferrin receptor increases expression ISO ginkgetin results in increased expression of TFRC protein CTD PMID:25968939 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO ginkgetin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein] CTD PMID:25968939 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
meclofenamic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c1 aldo-keto reductase family 1, member C1 decreases activity ISO Meclofenamic Acid results in decreased activity of AKR1C1 protein CTD PMID:19010312 PMID:26362498 PMID:27163852 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO Meclofenamic Acid results in decreased activity of AKR1C2 protein CTD PMID:19010312 PMID:26362498 PMID:27163852 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO Meclofenamic Acid results in decreased activity of AKR1C3 protein CTD PMID:19010312 PMID:26362498 PMID:27163852 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase decreases activity ISO Meclofenamic Acid results in decreased activity of ALOX5 protein CTD PMID:3020588 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G Ren renin multiple interactions EXP Meclofenamic Acid inhibits the reaction [Yohimbine results in increased expression of REN protein] CTD PMID:6323192 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Sell selectin L decreases expression ISO Meclofenamic Acid results in decreased expression of SELL protein CTD PMID:12147693 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456 		JBrowse link
G Slc16a2 solute carrier family 16 member 2 multiple interactions ISO Meclofenamic Acid inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine] CTD PMID:28119167 NCBI chr  X:68,725,365...68,848,572
Ensembl chr  X:68,723,261...68,848,771 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases activity ISO Meclofenamic Acid results in decreased activity of SULT1A1 protein CTD PMID:17073578 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 decreases activity ISO Meclofenamic Acid results in decreased activity of SULT1E1 protein CTD PMID:17073578 NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Meclofenamic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:10328874 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions ISO Meclofenamic Acid inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Meclofenamic Acid inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone] CTD PMID:19740398 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
methyl caffeate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO methyl caffeate analog results in decreased phosphorylation of AKT1 protein CTD PMID:25481497 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO methyl caffeate results in increased expression of BAX protein CTD PMID:26415618 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO methyl caffeate binds to and results in decreased expression of BCL2 protein CTD PMID:26415618 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bid BH3 interacting domain death agonist increases expression ISO methyl caffeate results in increased expression of BID protein CTD PMID:26415618 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Casp3 caspase 3 increases activity ISO methyl caffeate results in increased activity of CASP3 protein CTD PMID:26415618 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO methyl caffeate analog results in increased expression of CDKN1A protein CTD PMID:25481497 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Kdr kinase insert domain receptor decreases expression ISO methyl caffeate analog results in decreased expression of KDR protein CTD PMID:25481497 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO methyl caffeate analog results in decreased phosphorylation of MAPK1 protein CTD PMID:25481497 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO methyl caffeate analog results in decreased phosphorylation of MAPK3 protein CTD PMID:25481497 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mdm2 MDM2 proto-oncogene affects binding ISO methyl caffeate binds to MDM2 protein CTD PMID:26415618 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO methyl caffeate analog results in decreased expression of and results in decreased activity of MMP2 protein CTD PMID:25481497 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO methyl caffeate analog results in decreased expression of and results in decreased activity of MMP9 protein CTD PMID:25481497 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO methyl caffeate analog results in decreased phosphorylation of MTOR protein CTD PMID:25481497 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO methyl caffeate binds to and results in increased activity of PARP1 protein CTD PMID:26415618 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO methyl caffeate analog results in increased expression of TP53 protein CTD PMID:25481497 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO methyl caffeate analog results in decreased expression of and results in decreased secretion of VEGFA protein CTD PMID:25481497 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
phenethyl caffeate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin multiple interactions EXP caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in decreased expression of A2M mRNA] CTD PMID:20360939 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786 		JBrowse link
G Aanat aralkylamine N-acetyltransferase multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of AANAT mRNA CTD PMID:20360939 NCBI chr10:101,827,072...101,831,805
Ensembl chr10:101,827,301...101,831,801 		JBrowse link
G Abca5 ATP binding cassette subfamily A member 5 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ABCA5 mRNA CTD PMID:20360939 NCBI chr10:95,240,159...95,309,195
Ensembl chr10:95,240,154...95,308,976 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 decreases activity ISO caffeic acid phenethyl ester metabolite results in decreased activity of ABCC1 protein CTD PMID:15885658 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ABCC3 mRNA CTD PMID:20360939 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Acan aggrecan multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ACAN mRNA CTD PMID:20360939 NCBI chr 1:132,981,034...133,044,416
Ensembl chr 1:132,981,582...133,043,627 		JBrowse link
G Acot2 acyl-CoA thioesterase 2 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ACOT2 mRNA CTD PMID:20360939 NCBI chr 6:103,611,744...103,619,404
Ensembl chr 6:103,611,544...103,619,245 		JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions EXP caffeic acid phenethyl ester inhibits the reaction [Dexamethasone results in increased activity of ACP5 protein] CTD PMID:28363435 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929 		JBrowse link
G Ada adenosine deaminase multiple interactions EXP caffeic acid phenethyl ester inhibits the reaction [Methotrexate results in increased activity of ADA protein] CTD PMID:16325979 NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088 		JBrowse link
G Adam7 ADAM metallopeptidase domain 7 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ADAM7 mRNA CTD PMID:20360939 NCBI chr15:42,833,796...42,882,201
Ensembl chr15:42,833,796...42,882,201 		JBrowse link
G Adcy2 adenylate cyclase 2 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ADCY2 mRNA CTD PMID:20360939 NCBI chr 1:34,375,639...34,822,237
Ensembl chr 1:34,375,895...34,822,236 		JBrowse link
G Adra1d adrenoceptor alpha 1D multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ADRA1D mRNA CTD PMID:20360939 NCBI chr 3:118,793,356...118,809,354
Ensembl chr 3:118,793,346...118,809,354 		JBrowse link
G Agap2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of AGAP2 mRNA CTD PMID:20360939 NCBI chr 7:62,897,282...62,914,295
Ensembl chr 7:62,897,282...62,914,295 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO caffeic acid phenethyl ester promotes the reaction [Nitrogen Mustard Compounds results in decreased expression of AHR protein] CTD PMID:17204746 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Aimp1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 multiple interactions ISO caffeic acid phenethyl ester inhibits the reaction [AIMP1 protein results in increased expression of IL12B mRNA] CTD PMID:16365417 NCBI chr 2:221,151,907...221,175,458
Ensembl chr 2:221,151,904...221,175,728 		JBrowse link
G Akap9 A-kinase anchoring protein 9 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of AKAP9 mRNA CTD PMID:20360939 NCBI chr 4:30,056,738...30,192,716
Ensembl chr 4:30,056,738...30,192,606 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 decreases activity ISO caffeic acid phenethyl ester results in decreased activity of AKR1B1 protein CTD PMID:27163852 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 decreases activity ISO caffeic acid phenethyl ester results in decreased activity of AKR1B10 protein CTD PMID:27163852 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852 		JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 decreases activity ISO caffeic acid phenethyl ester results in decreased activity of AKR1C1 protein CTD PMID:27163852 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO caffeic acid phenethyl ester results in decreased activity of AKR1C2 protein CTD PMID:27163852 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO caffeic acid phenethyl ester results in decreased activity of AKR1C3 protein CTD PMID:27163852 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 affects phosphorylation ISO caffeic acid phenethyl ester analog affects the phosphorylation of AKT1 protein CTD PMID:32125059 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ALDH1A2 mRNA CTD PMID:20360939 NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO
EXP		 caffeic acid phenethyl ester inhibits the reaction [Carbon Tetrachloride results in increased activity of ALPL protein]
caffeic acid phenethyl ester inhibits the reaction [Dexamethasone results in decreased expression of ALPL protein]		 CTD PMID:18436364 PMID:28363435 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G Ankrd17 ankyrin repeat domain 17 multiple interactions EXP caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of ANKRD17 mRNA] CTD PMID:20360939 NCBI chr14:17,723,239...17,862,625
Ensembl chr14:17,721,932...17,862,617 		JBrowse link
G Arrb1 arrestin, beta 1 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ARRB1 mRNA CTD PMID:20360939 NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061 		JBrowse link
G Atf6 activating transcription factor 6 multiple interactions ISO [caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of ATF6 mRNA; GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of ATF6 mRNA] CTD PMID:28223344 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G Atox1 antioxidant 1 copper chaperone multiple interactions EXP caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of ATOX1 mRNA] CTD PMID:20360939 NCBI chr10:39,564,855...39,579,892
Ensembl chr10:39,564,857...39,579,950 		JBrowse link
G Axl Axl receptor tyrosine kinase multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of AXL mRNA CTD PMID:20360939 NCBI chr 1:81,265,656...81,296,278
Ensembl chr 1:81,265,088...81,296,265 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [Benzo(a)pyrene co-treated with caffeic acid phenethyl ester] results in increased expression of BAX mRNA CTD PMID:24289642 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member decreases phosphorylation ISO caffeic acid phenethyl ester results in decreased phosphorylation of BCAR1 protein CTD PMID:10741720 NCBI chr19:39,679,218...39,713,952
Ensembl chr19:39,679,204...39,713,907 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO caffeic acid phenethyl ester inhibits the reaction [Cadmium Chloride results in decreased expression of BCL2 protein] CTD PMID:34743973 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bgn biglycan multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of BGN mRNA CTD PMID:20360939 NCBI chr  X:151,197,296...151,209,458
Ensembl chr  X:151,197,273...151,209,461 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases expression ISO caffeic acid phenethyl ester results in decreased expression of BIRC2 protein CTD PMID:15291876 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression ISO caffeic acid phenethyl ester results in decreased expression of BIRC3 protein CTD PMID:15291876 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Cacna1a calcium voltage-gated channel subunit alpha1 A multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CACNA1A mRNA CTD PMID:20360939 NCBI chr19:23,520,741...23,819,971
Ensembl chr19:23,520,741...23,823,225 		JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CACNA1H mRNA CTD PMID:20360939 NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376 		JBrowse link
G Camk2d calcium/calmodulin-dependent protein kinase II delta multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CAMK2D mRNA CTD PMID:20360939 NCBI chr 2:215,023,785...215,287,351
Ensembl chr 2:215,024,004...215,286,178 		JBrowse link
G Capn8 calpain 8 multiple interactions EXP caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in decreased expression of CAPN8 mRNA] CTD PMID:20360939 NCBI chr13:94,252,218...94,316,146
Ensembl chr13:94,253,054...94,316,146 		JBrowse link
G Car3 carbonic anhydrase 3 multiple interactions EXP caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in decreased expression of CAR3 mRNA] CTD PMID:20360939 NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280 		JBrowse link
G Car4 carbonic anhydrase 4 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CAR4 mRNA CTD PMID:20360939 NCBI chr10:69,827,945...69,836,501
Ensembl chr10:69,827,945...69,836,501 		JBrowse link
G Casp1 caspase 1 decreases expression EXP caffeic acid phenethyl ester results in decreased expression of CASP1 protein CTD PMID:15469948 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 decreases activity
multiple interactions
increases activity		 EXP
ISO		 caffeic acid phenethyl ester results in decreased activity of CASP3 protein
caffeic acid phenethyl ester inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased activity of CASP3 protein]; caffeic acid phenethyl ester inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP3 protein]
caffeic acid phenethyl ester inhibits the reaction [Dexamethasone results in increased activity of CASP3 protein]
caffeic acid phenethyl ester analog results in increased activity of CASP3 protein		 CTD PMID:15469948 PMID:18436364 PMID:28363435 PMID:32125059 PMID:34743973 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO caffeic acid phenethyl ester inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP8 protein] CTD PMID:18436364 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO caffeic acid phenethyl ester inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased activity of CASP9 protein] CTD PMID:34743973 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions EXP
ISO		 caffeic acid phenethyl ester inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]; caffeic acid phenethyl ester promotes the reaction [Doxorubicin results in increased activity of CAT protein]
caffeic acid phenethyl ester inhibits the reaction [Bleomycin results in decreased expression of CAT protein]; caffeic acid phenethyl ester inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]		 CTD PMID:14745846 PMID:15369732 PMID:18436364 PMID:23570914 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO caffeic acid phenethyl ester inhibits the reaction [arsenite results in decreased expression of CCL2 mRNA] CTD PMID:16085347 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CCL5 mRNA CTD PMID:20360939 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO caffeic acid phenethyl ester results in decreased expression of CCNB1 protein CTD PMID:16085347 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO [Benzo(a)pyrene co-treated with caffeic acid phenethyl ester] results in decreased expression of CCND1 mRNA; caffeic acid phenethyl ester inhibits the reaction [sodium arsenite results in increased expression of CCND1 protein] CTD PMID:20420878 PMID:24289642 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccne1 cyclin E1 multiple interactions EXP
ISO		 caffeic acid phenethyl ester inhibits the reaction [CDK2 protein binds to CCNE1 protein]
[Tretinoin co-treated with caffeic acid phenethyl ester] inhibits the reaction [CDK2 protein binds to CCNE1 protein]		 CTD PMID:15885897 PMID:16766008 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cd14 CD14 molecule multiple interactions
increases expression		 EXP
ISO		 [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CD14 mRNA
caffeic acid phenethyl ester results in increased expression of CD14 protein
caffeic acid phenethyl ester promotes the reaction [Tretinoin results in increased expression of CD14 protein]		 CTD PMID:16766008 PMID:20360939 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261 		JBrowse link
G Cd151 CD151 molecule (Raph blood group) multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CD151 mRNA CTD PMID:20360939 NCBI chr 1:196,564,744...196,568,753
Ensembl chr 1:196,565,181...196,568,753 		JBrowse link
G Cd86 CD86 molecule multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CD86 mRNA CTD PMID:20360939 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO caffeic acid phenethyl ester results in decreased expression of CDK1 protein CTD PMID:16085347 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions EXP
ISO		 caffeic acid phenethyl ester inhibits the reaction [CDK2 protein binds to CCNE1 protein]
[Tretinoin co-treated with caffeic acid phenethyl ester] inhibits the reaction [CDK2 protein binds to CCNE1 protein]		 CTD PMID:15885897 PMID:16766008 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions		 ISO
EXP		 caffeic acid phenethyl ester results in increased expression of CDKN1A protein
[Benzo(a)pyrene co-treated with caffeic acid phenethyl ester] results in increased expression of CDKN1A mRNA; caffeic acid phenethyl ester inhibits the reaction [Folic Acid results in increased expression of CDKN1A protein]; Tretinoin promotes the reaction [caffeic acid phenethyl ester results in increased expression of CDKN1A protein]		 CTD PMID:15885897 PMID:16766008 PMID:24289642 PMID:26056802 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression
multiple interactions		 EXP
ISO		 caffeic acid phenethyl ester results in increased expression of CDKN1B protein
caffeic acid phenethyl ester inhibits the reaction [Folic Acid results in increased expression of CDKN1B protein]		 CTD PMID:15885897 PMID:26056802 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression
multiple interactions		 EXP caffeic acid phenethyl ester results in increased expression of CDKN2A protein
caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in decreased expression of CDKN2A mRNA]		 CTD PMID:15885897 PMID:20360939 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CDKN2C mRNA CTD PMID:20360939 NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278 		JBrowse link
G Ceacam4 CEA cell adhesion molecule 4 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of CEACAM10 mRNA CTD PMID:20360939 NCBI chr 1:80,376,667...80,382,943
Ensembl chr 1:80,376,648...80,382,915 		JBrowse link
G Cebpe CCAAT/enhancer binding protein epsilon multiple interactions
increases expression		 ISO Tretinoin promotes the reaction [caffeic acid phenethyl ester results in increased expression of CEBPE protein] CTD PMID:16766008 NCBI chr15:28,169,885...28,171,283
Ensembl chr15:28,169,704...28,171,814 		JBrowse link
G Cers2 ceramide synthase 2 multiple interactions ISO [caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of CERS2 mRNA; GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of CERS2 mRNA]; NR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of CERS2 mRNA] CTD PMID:28223344 NCBI chr 2:182,890,527...182,898,805
Ensembl chr 2:182,890,493...182,933,314 		JBrowse link
G Cers4 ceramide synthase 4 multiple interactions ISO [caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of CERS4 mRNA; GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of CERS4 mRNA]; NR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of CERS4 mRNA] CTD PMID:28223344 NCBI chr12:2,851,784...2,890,244
Ensembl chr12:2,851,784...2,886,828 		JBrowse link
G Cgm4 carcinoembryonic antigen gene family 4 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CGM4 mRNA CTD PMID:20360939 NCBI chr 1:77,776,447...77,789,408
Ensembl chr 1:77,776,447...77,789,396 		JBrowse link
G Chrna2 cholinergic receptor nicotinic alpha 2 subunit multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CHRNA2 mRNA CTD PMID:20360939 NCBI chr15:40,342,317...40,358,601
Ensembl chr15:40,342,317...40,358,601 		JBrowse link
G Chrne cholinergic receptor nicotinic epsilon subunit multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of CHRNE mRNA CTD PMID:20360939 NCBI chr10:55,331,211...55,339,923
Ensembl chr10:55,331,212...55,335,530 		JBrowse link
G Clcn1 chloride voltage-gated channel 1 multiple interactions EXP caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of CLCN1 mRNA] CTD PMID:20360939 NCBI chr 4:71,171,949...71,201,483
Ensembl chr 4:71,172,547...71,199,984 		JBrowse link
G Cldn2 claudin 2 decreases expression
multiple interactions		 ISO caffeic acid phenethyl ester results in decreased expression of CLDN2 mRNA; caffeic acid phenethyl ester results in decreased expression of CLDN2 protein
Cantharidin inhibits the reaction [caffeic acid phenethyl ester results in decreased expression of CLDN2 protein]; Chloroquine inhibits the reaction [caffeic acid phenethyl ester results in decreased expression of CLDN2 protein]; CLDN2 protein inhibits the reaction [caffeic acid phenethyl ester results in increased susceptibility to and results in increased activity of Doxorubicin]		 CTD PMID:29597147 NCBI chr  X:103,459,870...103,473,794
Ensembl chr  X:103,459,780...103,474,838 		JBrowse link
G Cldn7 claudin 7 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CLDN7 mRNA CTD PMID:20360939 NCBI chr10:54,689,684...54,692,177
Ensembl chr10:54,689,987...54,692,171 		JBrowse link
G Clic5 chloride intracellular channel 5 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CLIC5 mRNA CTD PMID:20360939 NCBI chr 9:16,710,980...16,813,427
Ensembl chr 9:16,710,980...16,813,427 		JBrowse link
G Clock clock circadian regulator multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CLOCK mRNA CTD PMID:20360939 NCBI chr14:31,908,542...31,992,673
Ensembl chr14:31,908,566...31,990,400 		JBrowse link
G Col18a1 collagen type XVIII alpha 1 chain increases expression ISO caffeic acid phenethyl ester results in increased expression of COL18A1 protein CTD PMID:20433813 NCBI chr20:11,474,104...11,582,593
Ensembl chr20:11,474,104...11,582,593 		JBrowse link
G Cox4i2 cytochrome c oxidase subunit 4i2 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of COX4I2 mRNA CTD PMID:20360939 NCBI chr 3:141,228,443...141,239,337
Ensembl chr 3:141,228,443...141,239,331 		JBrowse link
G Cox6a2 cytochrome c oxidase subunit 6A2 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of COX6A2 mRNA CTD PMID:20360939 NCBI chr 1:182,788,528...182,790,746
Ensembl chr 1:182,788,528...182,789,274 		JBrowse link
G Cox7a2 cytochrome c oxidase subunit 7A2 multiple interactions EXP caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of COX7A2 mRNA] CTD PMID:20360939 NCBI chr 8:80,716,824...80,720,922
Ensembl chr14:51,301,168...51,301,633 		JBrowse link
G Crmp1 collapsin response mediator protein 1 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CRMP1 mRNA CTD PMID:20360939 NCBI chr14:73,509,933...73,556,192
Ensembl chr14:73,509,933...73,556,177 		JBrowse link
G Cs citrate synthase multiple interactions ISO [caffeic acid phenethyl ester co-treated with Dietary Fats] results in increased activity of CS protein; [caffeic acid phenethyl ester co-treated with Dietary Fats] results in increased expression of CS mRNA; NR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in increased activity of CS protein]; NR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in increased expression of CS mRNA] CTD PMID:28223344 NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421 		JBrowse link
G Csk C-terminal Src kinase multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CSK mRNA CTD PMID:20360939 NCBI chr 8:58,029,748...58,048,742
Ensembl chr 8:58,029,749...58,048,292 		JBrowse link
G Cspg4 chondroitin sulfate proteoglycan 4 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CSPG4 mRNA CTD PMID:20360939 NCBI chr 8:57,264,962...57,300,010
Ensembl chr 8:57,264,962...57,300,010 		JBrowse link
G Ctnnb1 catenin beta 1 decreases expression ISO caffeic acid phenethyl ester results in decreased expression of CTNNB1 protein CTD PMID:10783313 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Ctsk cathepsin K multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CTSK mRNA CTD PMID:20360939 NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550 		JBrowse link
G Ctsm cathepsin M multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of CTSM mRNA CTD PMID:20360939 NCBI chr17:3,236,848...3,242,265
Ensembl chr17:3,236,859...3,242,265 		JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CXCR3 mRNA CTD PMID:20360939 NCBI chr  X:66,844,318...66,846,969
Ensembl chr  X:66,844,318...66,846,969 		JBrowse link
G Cyb5a cytochrome b5 type A multiple interactions EXP caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in decreased expression of CYB5A mRNA] CTD PMID:20360939 NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535
Ensembl chr18:78,202,342...78,258,535 		JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions EXP caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of CYBA mRNA] CTD PMID:20360939 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP caffeic acid phenethyl ester inhibits the reaction [Calcium results in increased secretion of CYCS protein] CTD PMID:15469948 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases expression		 EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CYP1A2 mRNA
caffeic acid phenethyl ester results in decreased expression of CYP1A2 protein		 CTD PMID:20360939 PMID:22291063 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2a2 cytochrome P450, family 2, subfamily a, polypeptide 2 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CYP2A2 mRNA CTD PMID:20360939 NCBI chr 1:82,263,833...82,289,487
Ensembl chr 1:82,263,833...82,289,487 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions
decreases expression		 EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CYP2B1 mRNA
caffeic acid phenethyl ester results in decreased expression of CYP2B1 protein		 CTD PMID:20360939 PMID:22291063 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 decreases expression EXP caffeic acid phenethyl ester results in decreased expression of CYP2B2 protein CTD PMID:22291063 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566 		JBrowse link
G Cyp2c13 cytochrome P450, family 2, subfamily c, polypeptide 13 multiple interactions EXP caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in decreased expression of CYP2C13 mRNA] CTD PMID:20360939 NCBI chr 1:238,786,764...238,867,195
Ensembl chr 1:238,786,765...238,867,191 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP
ISO		 [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CYP2E1 mRNA
caffeic acid phenethyl ester inhibits the reaction [CYP2E1 protein results in increased hydroxylation of aniline]		 CTD PMID:18436364 PMID:20360939 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a18 cytochrome P450, family 3, subfamily a, polypeptide 18 multiple interactions EXP caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in decreased expression of CYP3A18 mRNA] CTD PMID:20360939 NCBI chr12:8,880,528...8,930,382
Ensembl chr12:8,880,528...8,930,381 		JBrowse link
G Cyth2 cytohesin 2 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of CYTH2 mRNA CTD PMID:20360939 NCBI chr 1:96,284,252...96,291,090
Ensembl chr 1:96,284,252...96,291,092 		JBrowse link
G Dbn1 drebrin 1 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of DBN1 mRNA CTD PMID:20360939 NCBI chr17:9,150,608...9,164,982
Ensembl chr17:9,150,659...9,164,984 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO [caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of DDIT3 mRNA; GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of DDIT3 mRNA]; NR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of DDIT3 mRNA] CTD PMID:28223344 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Deaf1 DEAF1 transcription factor multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of DEAF1 mRNA CTD PMID:20360939 NCBI chr 1:196,401,857...196,435,541
Ensembl chr 1:196,401,857...196,435,541 		JBrowse link
G Degs1 delta(4)-desaturase, sphingolipid 1 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of DEGS1 mRNA CTD PMID:20360939 NCBI chr13:93,946,154...93,953,677
Ensembl chr13:93,946,157...93,953,664 		JBrowse link
G Degs2 delta(4)-desaturase, sphingolipid 2 multiple interactions ISO [caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of DEGS2 mRNA; GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of DEGS2 mRNA]; NR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of DEGS2 mRNA] CTD PMID:28223344 NCBI chr 6:127,596,063...127,613,293
Ensembl chr 6:127,596,071...127,613,293 		JBrowse link
G Dgkb diacylglycerol kinase, beta multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of DGKB mRNA CTD PMID:20360939 NCBI chr 6:54,640,948...55,397,210
Ensembl chr 6:54,641,614...55,397,043 		JBrowse link
G Dhfr dihydrofolate reductase multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of DHFR mRNA CTD PMID:20360939 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713 		JBrowse link
G Disc1 DISC1 scaffold protein multiple interactions EXP caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of DISC1 mRNA] CTD PMID:20360939 NCBI chr19:53,014,201...53,223,617
Ensembl chr19:53,014,616...53,219,778 		JBrowse link
G Dmrt1 doublesex and mab-3 related transcription factor 1 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of DMRT1 mRNA CTD PMID:20360939 NCBI chr 1:223,142,859...223,241,333
Ensembl chr 1:223,142,859...223,241,333 		JBrowse link
G Dnah10 dynein, axonemal, heavy chain 10 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of DNAH10 mRNA CTD PMID:20360939 NCBI chr12:31,823,451...31,946,857
Ensembl chr12:31,822,733...32,007,069 		JBrowse link
G Dnah5 dynein, axonemal, heavy chain 5 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of DNAH5 mRNA CTD PMID:20360939 NCBI chr 2:78,937,788...79,255,551
Ensembl chr 2:78,937,800...79,254,890 		JBrowse link
G Dpys dihydropyrimidinase multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of DPYS mRNA CTD PMID:20360939 NCBI chr 7:70,822,648...70,929,255
Ensembl chr 7:70,835,789...70,929,231 		JBrowse link
G Dusp6 dual specificity phosphatase 6 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of DUSP6 mRNA CTD PMID:20360939 NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185 		JBrowse link
G E2f6 E2F transcription factor 6 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of E2F6 mRNA CTD PMID:20360939 NCBI chr 6:39,592,224...39,608,685
Ensembl chr 6:39,592,228...39,608,683 		JBrowse link
G Echs1 enoyl-CoA hydratase, short chain 1 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ECHS1 mRNA CTD PMID:20360939 NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884 		JBrowse link
G Edn1 endothelin 1 multiple interactions ISO caffeic acid phenethyl ester inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 mRNA]; caffeic acid phenethyl ester inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 protein] CTD PMID:21926265 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Ets1 ETS proto-oncogene 1, transcription factor multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ETS1 mRNA CTD PMID:20360939 NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010 		JBrowse link
G Fabp7 fatty acid binding protein 7 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of FABP7 mRNA CTD PMID:20360939 NCBI chr20:37,123,193...37,126,725
Ensembl chr20:37,123,193...37,126,880 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO caffeic acid phenethyl ester inhibits the reaction [Carbon Tetrachloride results in increased expression of FAS protein] CTD PMID:18436364 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand multiple interactions ISO caffeic acid phenethyl ester inhibits the reaction [Carbon Tetrachloride results in increased expression of FASL protein] CTD PMID:18436364 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fgf19 fibroblast growth factor 19 multiple interactions ISO [caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of FGF15 mRNA; GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of FGF15 mRNA] CTD PMID:28223344 NCBI chr 1:200,056,656...200,059,944
Ensembl chr 1:200,056,644...200,060,287 		JBrowse link
G Fgf7 fibroblast growth factor 7 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of FGF7 mRNA CTD PMID:20360939 NCBI chr 3:113,280,448...113,333,279
Ensembl chr 3:113,281,283...113,332,929 		JBrowse link
G Fgg fibrinogen gamma chain multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of FGG mRNA CTD PMID:20360939 NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322 		JBrowse link
G Fmo2 flavin containing dimethylaniline monoxygenase 2 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of FMO2 mRNA CTD PMID:20360939 NCBI chr13:75,221,149...75,244,377
Ensembl chr13:75,224,402...75,244,308 		JBrowse link
G Foxc2 forkhead box C2 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of FOXC2 mRNA CTD PMID:20360939 NCBI chr19:49,186,034...49,188,736
Ensembl chr19:49,185,662...49,188,737 		JBrowse link
G Foxd1 forkhead box D1 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of FOXD1 mRNA CTD PMID:20360939 NCBI chr 2:29,702,558...29,704,978
Ensembl chr 2:29,702,558...29,704,978 		JBrowse link
G Frmd6 FERM domain containing 6 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of FRMD6 mRNA CTD PMID:20360939 NCBI chr 6:89,345,975...89,419,579
Ensembl chr 6:89,346,035...89,419,579 		JBrowse link
G Ftl1 ferritin light chain 1 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of FTL mRNA CTD PMID:20360939 NCBI chr 1:95,936,390...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725 		JBrowse link
G Fut2 fucosyltransferase 2 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of FUT2 mRNA CTD PMID:20360939 NCBI chr 1:96,119,549...96,139,567
Ensembl chr 1:96,119,371...96,140,360 		JBrowse link
G Gas6 growth arrest specific 6 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of GAS6 mRNA CTD PMID:20360939 NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904 		JBrowse link
G Gc GC, vitamin D binding protein multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of GC mRNA CTD PMID:20360939 NCBI chr14:18,632,146...18,667,563
Ensembl chr14:18,632,135...18,667,567 		JBrowse link
G Gch1 GTP cyclohydrolase 1 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of GCH1 mRNA CTD PMID:20360939 NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO caffeic acid phenethyl ester inhibits the reaction [Bleomycin results in decreased expression of GCLC protein] CTD PMID:23570914 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gdnf glial cell derived neurotrophic factor multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of GDNF mRNA CTD PMID:20360939 NCBI chr 2:56,893,992...56,919,935
Ensembl chr 2:56,895,010...56,917,209 		JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions
increases expression		 EXP NGFR protein affects the susceptibility to [caffeic acid phenethyl ester results in increased expression of GFAP protein] CTD PMID:20836997 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Gfer growth factor, augmenter of liver regeneration multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of GFER mRNA CTD PMID:20360939 NCBI chr10:13,718,489...13,721,782
Ensembl chr10:13,718,489...13,720,869 		JBrowse link
G Gfra4 GDNF family receptor alpha 4 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of GFRA4 mRNA CTD PMID:20360939 NCBI chr 3:118,254,937...118,262,252
Ensembl chr 3:118,255,402...118,258,329 		JBrowse link
G Ghr growth hormone receptor multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of GHR mRNA CTD PMID:20360939 NCBI chr 2:52,541,452...52,804,960
Ensembl chr 2:52,542,594...52,804,735 		JBrowse link
G Gjb1 gap junction protein, beta 1 multiple interactions EXP caffeic acid phenethyl ester inhibits the reaction [GJB1 protein results in decreased expression of IL1B mRNA]; caffeic acid phenethyl ester inhibits the reaction [GJB1 protein results in decreased expression of IL1B protein] CTD PMID:15350541 NCBI chr  X:66,501,848...66,509,783
Ensembl chr  X:66,501,820...66,509,925 		JBrowse link
G Gjc2 gap junction protein, gamma 2 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of GJC2 mRNA CTD PMID:20360939 NCBI chr10:43,962,642...43,971,358
Ensembl chr10:43,962,642...43,970,467 		JBrowse link
G Gls glutaminase multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of GLS mRNA CTD PMID:20360939 NCBI chr 9:49,344,616...49,416,900
Ensembl chr 9:49,344,781...49,416,900 		JBrowse link
G Gnal G protein subunit alpha L multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of GNAL mRNA CTD PMID:20360939 NCBI chr18:60,622,311...60,762,599
Ensembl chr18:60,622,311...60,762,599 		JBrowse link
G Golga2 golgin A2 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of GOLGA2 mRNA CTD PMID:20360939 NCBI chr 3:15,583,862...15,604,279
Ensembl chr 3:15,584,039...15,604,279 		JBrowse link
G Gpr19 G protein-coupled receptor 19 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of GPR19 mRNA CTD PMID:20360939 NCBI chr 4:167,710,944...167,739,232
Ensembl chr 4:167,710,666...167,741,036 		JBrowse link
G Grik2 glutamate ionotropic receptor kainate type subunit 2 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of GRIK2 mRNA CTD PMID:20360939 NCBI chr20:52,135,325...52,833,061
Ensembl chr20:52,133,851...52,838,375 		JBrowse link
G Grik5 glutamate ionotropic receptor kainate type subunit 5 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of GRIK5 mRNA CTD PMID:20360939 NCBI chr 1:80,605,878...80,667,896
Ensembl chr 1:80,605,892...80,667,125 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of GSR mRNA CTD PMID:20360939 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gstk1 glutathione S-transferase kappa 1 multiple interactions EXP caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of GSTK1 mRNA] CTD PMID:20360939 NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases expression EXP caffeic acid phenethyl ester results in decreased expression of GSTP1 protein CTD PMID:17106925 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Gstt2 glutathione S-transferase theta 2 multiple interactions EXP caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of GSTT2 mRNA] CTD PMID:20360939 NCBI chr20:12,819,617...12,823,288
Ensembl chr20:12,819,170...12,823,288 		JBrowse link
G Gyg1 glycogenin 1 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of GYG1 mRNA CTD PMID:20360939 NCBI chr 2:102,611,888...102,653,916
Ensembl chr 2:102,598,496...102,653,797 		JBrowse link
G H2ac1 H2A clustered histone 1 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of H2AC1 mRNA CTD PMID:20360939 NCBI chr17:41,171,384...41,171,776
Ensembl chr17:41,135,489...41,172,022 		JBrowse link
G Hamp hepcidin antimicrobial peptide multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of HAMP mRNA CTD PMID:20360939 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891 		JBrowse link
G Hdgf heparin binding growth factor multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of HDGF mRNA CTD PMID:20360939 NCBI chr 2:173,370,147...173,379,756
Ensembl chr 2:173,370,465...173,379,747 		JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 multiple interactions EXP caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in decreased expression of HMGCS2 mRNA] CTD PMID:20360939 NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 ISO
EXP		 caffeic acid phenethyl ester results in increased expression of HMOX1 protein
caffeic acid phenethyl ester analog results in increased expression of HMOX1 mRNA; caffeic acid phenethyl ester analog results in increased expression of HMOX1 protein; caffeic acid phenethyl ester results in increased expression of HMOX1 mRNA; caffeic acid phenethyl ester results in increased expression of HMOX1 protein
caffeic acid phenethyl ester inhibits the reaction [Fructose results in increased expression of HMOX1 protein]; caffeic acid phenethyl ester inhibits the reaction [Streptozocin results in increased expression of HMOX1 protein]		 CTD PMID:20226179 PMID:20950636 PMID:21472898 PMID:23942037 PMID:24508943 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hnrnpr heterogeneous nuclear ribonucleoprotein R multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of HNRNPR mRNA CTD PMID:20360939 NCBI chr 5:148,542,999...148,574,888
Ensembl chr 5:148,543,044...148,574,867 		JBrowse link
G Hpcal4 hippocalcin-like 4 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of HPCAL4 mRNA CTD PMID:20360939 NCBI chr 5:135,454,477...135,466,417
Ensembl chr 5:135,454,540...135,466,416 		JBrowse link
G Hspa2 heat shock protein family A (Hsp70) member 2 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of HSPA2 mRNA CTD PMID:20360939 NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO [caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of HSPA5 mRNA; GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of HSPA5 mRNA]; NR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of HSPA5 mRNA] CTD PMID:28223344 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of HSPB1 mRNA CTD PMID:20360939 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743 		JBrowse link
G Hspb2 heat shock protein family B (small) member 2 multiple interactions EXP [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of HSPB2 mRNA CTD PMID:20360939 NCBI chr 8:51,093,267...51,094,864
Ensembl chr 8:51,081,342...51,094,533 		JBrowse link
G Idh3a isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha multiple interactions ISO [caffeic acid phenethyl ester co-treated with Dietary Fats] results in increased expression of IDH3A mRNA; NR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in increased expression of IDH3A mRNA] CTD PMID:28223344 NCBI chr 8:54,971,694...54,991,085
Ensembl chr 8:54,971,740...54,991,084