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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pyrrolizidine
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Accession:CHEBI:64950 term browser browse the term
Definition:A bicyclic organonitrogen heterocyclic compound comprised of two ortho-fused pyrrolidine rings which share a common nitrogen atom.
Synonyms:exact_synonym: hexahydro-1H-pyrrolizine
 related_synonym: 1-azabicyclo[3.3.0]octane;   2,3,5,6,7,8-hexahydro-1H-pyrrolizine;   Formula=C7H13N;   Hexahydropyrrolizine;   InChI=1S/C7H13N/c1-3-7-4-2-6-8(7)5-1/h7H,1-6H2;   InChIKey=ADRDEXBBJTUCND-UHFFFAOYSA-N;   SMILES=C1CC2CCCN2C1
 xref: CAS:643-20-9;   Reaxys:103088;   Wikipedia:Pyrrolizidine



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monocrotaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abraxas1 abraxas 1, BRCA1 A complex subunit multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of ABRAXAS1 mRNA CTD PMID:33884520 NCBI chr14:8,796,281...8,810,625
Ensembl chr14:8,796,266...8,810,622
JBrowse link
G Ace angiotensin I converting enzyme increases expression
multiple interactions
EXP Monocrotaline results in increased expression of ACE mRNA; Monocrotaline results in increased expression of ACE protein
angiotensin I (1-7) inhibits the reaction [Monocrotaline results in increased expression of ACE mRNA]; magnolol inhibits the reaction [Monocrotaline results in increased expression of ACE protein]
CTD PMID:20581171 PMID:30466619 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Ace2 angiotensin I converting enzyme 2 decreases expression
multiple interactions
EXP Monocrotaline results in decreased expression of ACE2 protein
[Monocrotaline co-treated with angiotensin I (1-7)] results in increased expression of ACE2 mRNA; magnolol inhibits the reaction [Monocrotaline results in decreased expression of ACE2 protein]
CTD PMID:20581171 PMID:30466619 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Acta2 actin alpha 2, smooth muscle increases expression
multiple interactions
EXP Monocrotaline results in increased expression of ACTA2 protein
18alpha-glycyrrhetinic acid inhibits the reaction [Monocrotaline results in increased expression of ACTA2 protein]
CTD PMID:31325423 PMID:31734320 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Actb actin, beta multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of ACTB mRNA CTD PMID:33884520 NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877
JBrowse link
G Agt angiotensinogen increases expression
multiple interactions
EXP Monocrotaline results in increased expression of AGT protein
magnolol inhibits the reaction [Monocrotaline results in increased expression of AGT protein]
CTD PMID:16936438 PMID:30466619 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions
increases expression
EXP magnolol inhibits the reaction [Monocrotaline results in increased expression of AGTR1A protein] CTD PMID:30466619 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
increases phosphorylation
multiple interactions
EXP Monocrotaline results in decreased phosphorylation of AKT1 protein
Monocrotaline results in increased phosphorylation of AKT1 protein
magnolol inhibits the reaction [Monocrotaline results in increased phosphorylation of AKT1 protein]; Monocrotaline affects the expression of and affects the phosphorylation of AKT1 protein; Quercetin affects the reaction [Monocrotaline affects the expression of and affects the phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [Monocrotaline results in increased phosphorylation of AKT1 protein]
CTD PMID:18801959 PMID:25460361 PMID:30466619 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Anapc13 anaphase promoting complex subunit 13 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of ANAPC13 mRNA CTD PMID:33884520 NCBI chr 8:103,205,520...103,213,936
Ensembl chr 8:103,205,520...103,213,936
JBrowse link
G Anapc2 anaphase promoting complex subunit 2 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of ANAPC2 mRNA CTD PMID:33884520 NCBI chr 3:8,086,434...8,098,182
Ensembl chr 3:8,086,462...8,098,178
JBrowse link
G Anxa5 annexin A5 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of ANXA5 mRNA CTD PMID:21224054 NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369
JBrowse link
G Arid1a AT-rich interaction domain 1A multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of ARID1A mRNA CTD PMID:33884520 NCBI chr 5:145,908,181...145,981,609
Ensembl chr 5:145,908,181...145,985,564
JBrowse link
G Arid2 AT-rich interaction domain 2 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of ARID2 mRNA CTD PMID:33884520 NCBI chr 7:127,447,192...127,565,987
Ensembl chr 7:127,447,278...127,563,512
JBrowse link
G Atm ATM serine/threonine kinase multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM protein
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of ATM mRNA
CTD PMID:21224054 PMID:33884520 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Atp6v0e2 ATPase, H+ transporting V0 subunit e2 increases expression ISO Monocrotaline results in increased expression of ATP6V0E2 mRNA CTD PMID:28818515 NCBI chr 4:77,484,868...77,488,016
Ensembl chr 4:77,482,226...77,488,777
JBrowse link
G Aurka aurora kinase A multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of AURKA mRNA CTD PMID:33884520 NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390
JBrowse link
G Babam2 BRISC and BRCA1 A complex member 2 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of BABAM2 mRNA CTD PMID:33884520 NCBI chr 6:24,369,021...24,833,335
Ensembl chr 6:24,369,022...24,833,951
JBrowse link
G Bard1 BRCA1 associated RING domain 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of BARD1 mRNA CTD PMID:33884520 NCBI chr 9:72,616,070...72,694,553
Ensembl chr 9:72,623,155...72,694,265
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of BAX mRNA CTD PMID:21224054 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of BCL2L1 mRNA CTD PMID:21224054 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 increases expression
multiple interactions
EXP Monocrotaline results in increased expression of BIRC5 mRNA
Quercetin inhibits the reaction [Monocrotaline results in increased expression of BIRC5 mRNA]
CTD PMID:25460361 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Blm BLM RecQ like helicase multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of BLM mRNA CTD PMID:33884520 NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312
JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 multiple interactions
decreases expression
EXP Fluoxetine inhibits the reaction [Monocrotaline results in decreased expression of BMPR2 mRNA]
Monocrotaline results in decreased expression of BMPR2 mRNA; Monocrotaline results in decreased expression of BMPR2 protein
CTD PMID:20522807 PMID:21619414 PMID:25460361 NCBI chr 9:61,192,718...61,307,280
Ensembl chr 9:61,190,566...61,301,809
JBrowse link
G Brca2 BRCA2, DNA repair associated multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of BRCA2 mRNA CTD PMID:33884520 NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567
JBrowse link
G Brd7 bromodomain containing 7 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of BRD7 mRNA CTD PMID:33884520 NCBI chr19:18,708,792...18,737,500
Ensembl chr19:18,709,022...18,737,494
JBrowse link
G Brip1 BRCA1 interacting helicase 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of BRIP1 mRNA CTD PMID:33884520 NCBI chr10:70,907,266...71,031,502
Ensembl chr10:70,907,371...71,030,324
JBrowse link
G Casp3 caspase 3 increases expression
decreases expression
multiple interactions
EXP Monocrotaline results in increased expression of CASP3 mRNA
Monocrotaline results in decreased expression of CASP3 protein
Fluoxetine inhibits the reaction [Monocrotaline results in decreased expression of CASP3 protein]; Simvastatin inhibits the reaction [Monocrotaline results in increased expression of CASP3 mRNA]
CTD PMID:21619414 PMID:22022327 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase multiple interactions
increases activity
EXP Curcumin analog inhibits the reaction [Monocrotaline results in increased activity of CAT protein] CTD PMID:31407471 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cav1 caveolin 1 decreases expression
multiple interactions
EXP Monocrotaline results in decreased expression of CAV1 mRNA; Monocrotaline results in decreased expression of CAV1 protein
NCP-2454 inhibits the reaction [Monocrotaline results in decreased expression of CAV1 protein]
CTD PMID:24835767 PMID:25275723 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
JBrowse link
G Cav2 caveolin 2 decreases expression EXP Monocrotaline results in decreased expression of CAV2 mRNA; Monocrotaline results in decreased expression of CAV2 protein CTD PMID:24835767 NCBI chr 4:45,616,766...45,624,144
Ensembl chr 4:45,616,712...45,624,244
JBrowse link
G Cavin1 caveolae associated protein 1 decreases expression EXP Monocrotaline results in decreased expression of CAVIN1 mRNA; Monocrotaline results in decreased expression of CAVIN1 protein CTD PMID:24835767 NCBI chr10:85,884,100...85,896,136
Ensembl chr10:85,889,036...85,896,120
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
multiple interactions
EXP Monocrotaline results in increased expression of CCL2 mRNA; Monocrotaline results in increased expression of CCL2 protein
liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of CCL2 mRNA]; liquiritin inhibits the reaction [Monocrotaline results in increased expression of CCL2 mRNA]
CTD PMID:25051504 PMID:31589899 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 affects expression EXP Monocrotaline affects the expression of CCL5 protein CTD PMID:25051504 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CCNB1 mRNA CTD PMID:33884520 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnb2 cyclin B2 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CCNB2 mRNA CTD PMID:33884520 NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CCND1 mRNA CTD PMID:21224054 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccng1 cyclin G1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CCNG1 mRNA CTD PMID:21224054 NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641
JBrowse link
G Cdc20 cell division cycle 20 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of CDC20 mRNA CTD PMID:33884520 NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
JBrowse link
G Cdc25a cell division cycle 25A multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CDC25A mRNA CTD PMID:33884520 NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701
JBrowse link
G Cdc25b cell division cycle 25B multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CDC25B mRNA CTD PMID:33884520 NCBI chr 3:118,407,127...118,417,272
Ensembl chr 3:118,407,128...118,417,272
JBrowse link
G Cdc25c cell division cycle 25C multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CDC25C mRNA CTD PMID:33884520 NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
JBrowse link
G Cdc7 cell division cycle 7 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CDC7 mRNA CTD PMID:33884520 NCBI chr14:2,804,660...2,824,796
Ensembl chr14:2,804,661...2,824,778
JBrowse link
G Cdh2 cadherin 2 increases expression EXP Monocrotaline results in increased expression of CDH2 protein CTD PMID:31734320 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Cdh5 cadherin 5 decreases expression EXP Monocrotaline results in decreased expression of CDH5 protein CTD PMID:31734320 NCBI chr19:815,415...854,478
Ensembl chr19:815,411...854,368
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CDK1 mRNA CTD PMID:33884520 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CDK2 mRNA CTD PMID:33884520 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CDKN1A mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CDKN1A protein
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of CDKN1A mRNA
CTD PMID:21224054 PMID:33884520 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of CHEK1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CHEK1 mRNA CTD PMID:33884520 NCBI chr 8:36,420,565...36,443,477 JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CHEK2 mRNA CTD PMID:21224054 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
JBrowse link
G Clspn claspin multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CLSPN mRNA CTD PMID:33884520 NCBI chr 5:138,850,119...138,885,037
Ensembl chr 5:138,850,128...138,885,034
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP [Monocrotaline co-treated with LGALS3 protein] promotes the reaction [[Monocrotaline co-treated with TGFB1] results in increased expression of COL1A1 protein]; [Monocrotaline co-treated with LGALS3 protein] results in increased expression of COL1A1 protein; [Monocrotaline co-treated with TGFB1] results in increased expression of COL1A1 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[Monocrotaline co-treated with TGFB1] results in increased expression of COL1A1 protein] CTD PMID:27870162 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
increases expression
decreases expression
EXP Fluoxetine inhibits the reaction [Monocrotaline results in decreased expression of CTNNB1 protein]; magnolol inhibits the reaction [Monocrotaline results in increased expression of CTNNB1 protein] CTD PMID:21619414 PMID:30466619 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions
decreases expression
ISO
EXP
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CXCL10 mRNA
Monocrotaline results in decreased expression of CXCL10 protein
CTD PMID:21224054 PMID:25051504 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cxcl16 C-X-C motif chemokine ligand 16 multiple interactions ISO [Lipopolysaccharides co-treated with Monocrotaline] results in increased expression of CXCL16 protein; [Monocrotaline co-treated with Lipopolysaccharides] results in decreased expression of CXCL16 protein CTD PMID:21279329 PMID:21327618 NCBI chr10:55,166,721...55,171,316
Ensembl chr10:55,166,723...55,171,592
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO [Monocrotaline co-treated with Lipopolysaccharides] results in increased expression of CXCL1 protein; F3 protein promotes the reaction [[Monocrotaline co-treated with Lipopolysaccharides] results in increased expression of CXCL1 protein] CTD PMID:22407844 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cybb cytochrome b-245 beta chain increases expression EXP Monocrotaline results in increased expression of CYBB mRNA; Monocrotaline results in increased expression of CYBB protein CTD PMID:24835767 PMID:24947524 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP1B1 mRNA CTD PMID:21224054 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP2A5 mRNA CTD PMID:21224054 NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP2B10 mRNA CTD PMID:21224054 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP2B9 mRNA CTD PMID:21224054 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions ISO CYP2C19 protein results in increased metabolism of and results in increased activity of Monocrotaline CTD PMID:19818743 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing
increases expression
multiple interactions
ISO CYP3A4 protein results in increased metabolism of Monocrotaline
Monocrotaline results in increased expression of CYP3A4 mRNA
[CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of BRCA2 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of CDC20 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of CHEK1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of E2F8 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of KIF11 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of KIF23 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of PLK2 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of RFC5 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of ABRAXAS1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of ACTB mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of ANAPC2 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of ARID1A mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of ARID2 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of ATRIP mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of AURKA mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of BARD1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of BLM mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of BRD7 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of BRIP1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CCNB1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CCNB2 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CDC25A mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CDC25B mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CDC25C mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CDC7 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CDK1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CDK2 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CHEK1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CLSPN mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of E2F1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of E2F5 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of ESPL1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of FANCA mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of FANCB mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of FANCD2 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of FANCG mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of FBXO5 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of MDC1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of MRE11 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of MSH2 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of MSH6 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PHF10 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PKMYT1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PLK1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PLK4 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of POU2F1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PPM1J mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PPM1L mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PPP2R3B mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PRC1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PTTG1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RAD1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RAD21 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RBL1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RFC1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RFC2 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RFC3 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RFC4 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of SLC19A1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of SMARCB1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of SMARCC1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of SMC1A mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of SMC3 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of STAG2 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of TLK1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of ANAPC13 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of ATM mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of BABAM2 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of CDKN1A mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of GADD45A mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of MLH1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of PCNA mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of PLK3 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of PPP2CB mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of PPP2R5E mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of STAT1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of TOPBP1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of TP53 mRNA; [Monocrotaline results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; CYP3A4 protein results in increased metabolism of and results in increased activity of Monocrotaline; Dihydrotestosterone inhibits the reaction [[Monocrotaline results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA]; Flutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [[Monocrotaline results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA]]
CTD PMID:19818743 PMID:32682830 PMID:33884520 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP Monocrotaline results in increased expression of CYP3A23-3A1 mRNA CTD PMID:32682830 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP7A1 mRNA CTD PMID:21224054 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of DDIT3 mRNA CTD PMID:21224054 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of DNAJA1 mRNA CTD PMID:21224054 NCBI chr 5:55,842,414...55,853,326
Ensembl chr 5:55,842,426...55,853,967
JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of E2F1 mRNA
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of E2F1 mRNA
CTD PMID:21224054 PMID:33884520 NCBI chr 3:143,064,535...143,075,362 JBrowse link
G E2f5 E2F transcription factor 5 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of E2F5 mRNA CTD PMID:33884520 NCBI chr 2:86,997,331...87,012,901
Ensembl chr 2:86,997,332...87,012,990
JBrowse link
G E2f8 E2F transcription factor 8 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of E2F8 mRNA CTD PMID:33884520 NCBI chr 1:98,565,717...98,584,265
Ensembl chr 1:98,565,717...98,584,098
JBrowse link
G Edn1 endothelin 1 multiple interactions
increases expression
EXP 4-chlorobenzyltetrahydroberberine inhibits the reaction [Monocrotaline results in increased expression of EDN1 mRNA]; 4-chlorobenzyltetrahydroberberine inhibits the reaction [Monocrotaline results in increased expression of EDN1 protein]; Bosentan inhibits the reaction [Monocrotaline results in increased expression of EDN1 mRNA]; magnolol inhibits the reaction [Monocrotaline results in increased expression of EDN1 protein]; Simvastatin inhibits the reaction [Monocrotaline results in increased expression of EDN1 mRNA]
Monocrotaline results in increased expression of EDN1 mRNA; Monocrotaline results in increased expression of EDN1 protein
CTD PMID:16225752 PMID:20967148 PMID:22022327 PMID:30466619 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Ednra endothelin receptor type A multiple interactions
increases expression
EXP magnolol inhibits the reaction [Monocrotaline results in increased expression of EDNRA protein]; Simvastatin inhibits the reaction [Monocrotaline results in increased expression of EDNRA mRNA]
Monocrotaline results in increased expression of EDNRA mRNA; Monocrotaline results in increased expression of EDNRA protein
CTD PMID:20967148 PMID:22022327 PMID:30466619 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049
JBrowse link
G Egr1 early growth response 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of EGR1 mRNA CTD PMID:21224054 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Espl1 extra spindle pole bodies like 1, separase multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of ESPL1 mRNA CTD PMID:33884520 NCBI chr 7:133,424,027...133,450,984
Ensembl chr 7:133,424,130...133,450,984
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO [Monocrotaline co-treated with Lipopolysaccharides] results in increased expression of F3 protein; F3 protein promotes the reaction [[Monocrotaline co-treated with Lipopolysaccharides] results in increased expression of CXCL1 protein]; F3 protein results in increased susceptibility to [Monocrotaline co-treated with Lipopolysaccharides] CTD PMID:22407844 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Fanca FA complementation group A multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of FANCA mRNA CTD PMID:33884520 NCBI chr19:51,304,021...51,362,586
Ensembl chr19:51,304,021...51,362,527
JBrowse link
G Fancb FA complementation group B multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of FANCB mRNA CTD PMID:33884520 NCBI chr  X:29,403,771...29,420,484
Ensembl chr  X:29,403,771...29,420,192
JBrowse link
G Fancd2 FA complementation group D2 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of FANCD2 mRNA CTD PMID:33884520 NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412
JBrowse link
G Fancg FA complementation group G multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of FANCG mRNA CTD PMID:33884520 NCBI chr 5:57,230,287...57,240,067
Ensembl chr 5:57,231,685...57,240,029
JBrowse link
G Faslg Fas ligand multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FASL mRNA CTD PMID:21224054 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fbxo32 F-box protein 32 increases expression
multiple interactions
decreases expression
EXP Monocrotaline results in increased expression of FBXO32 mRNA
resveratrol inhibits the reaction [Monocrotaline results in decreased expression of FBXO32 mRNA]
CTD PMID:18801959 PMID:22146233 NCBI chr 7:89,731,626...89,764,761
Ensembl chr 7:89,730,232...89,765,436
JBrowse link
G Fbxo5 F-box protein 5 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of FBXO5 mRNA CTD PMID:33884520 NCBI chr 1:42,196,068...42,202,437
Ensembl chr 1:42,196,068...42,202,437
JBrowse link
G Flt4 Fms related receptor tyrosine kinase 4 decreases expression
multiple interactions
ISO Monocrotaline results in decreased expression of FLT4 mRNA
romiplostim inhibits the reaction [Monocrotaline results in decreased expression of FLT4 mRNA]; THPO protein inhibits the reaction [Monocrotaline results in decreased expression of FLT4 mRNA]
CTD PMID:33122006 NCBI chr10:33,913,725...33,954,770
Ensembl chr10:33,913,608...33,954,770
JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO1 mRNA CTD PMID:21224054 NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647
JBrowse link
G Fmo4 flavin containing dimethylaniline monoxygenase 4 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO4 mRNA CTD PMID:21224054 NCBI chr13:75,154,683...75,172,932
Ensembl chr13:75,154,684...75,172,874
JBrowse link
G Fn1 fibronectin 1 increases expression
multiple interactions
EXP Monocrotaline results in increased expression of FN1 protein
[Monocrotaline co-treated with TGFB1] results in increased expression of FN1 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[Monocrotaline co-treated with TGFB1] results in increased expression of FN1 protein]
CTD PMID:24947524 PMID:27870162 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Foxo3 forkhead box O3 decreases phosphorylation EXP Monocrotaline results in decreased phosphorylation of FOXO3 protein CTD PMID:18801959 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GADD45A mRNA
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of GADD45A mRNA
CTD PMID:21224054 PMID:33884520 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
decreases expression
EXP liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of GCLC mRNA]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of GCLC mRNA] CTD PMID:29908794 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions
decreases expression
EXP liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of GCLM mRNA]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of GCLM mRNA] CTD PMID:29908794 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gfap glial fibrillary acidic protein affects expression EXP Monocrotaline affects the expression of GFAP protein CTD PMID:21781985 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity
multiple interactions
EXP
ISO
Monocrotaline results in increased activity of GPT protein
liquiritigenin inhibits the reaction [Monocrotaline results in increased activity of GPT protein]; liquiritin inhibits the reaction [Monocrotaline results in increased activity of GPT protein]
[TBXA2R protein affects the susceptibility to Monocrotaline] which results in increased expression of ALT protein
CTD PMID:24418708 PMID:28818515 PMID:31470032 PMID:31589899 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GPX2 mRNA CTD PMID:21224054 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation
multiple interactions
EXP Monocrotaline results in increased phosphorylation of GSK3B protein
magnolol inhibits the reaction [Monocrotaline results in increased phosphorylation of GSK3B protein]
CTD PMID:30466619 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
increases activity
decreases expression
EXP Curcumin analog inhibits the reaction [Monocrotaline results in increased activity of GSR protein]; liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of GSR mRNA]; liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of GSR protein]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of GSR mRNA]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of GSR protein]
Monocrotaline results in decreased expression of GSR mRNA; Monocrotaline results in decreased expression of GSR protein
CTD PMID:29908794 PMID:31407471 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GSTM1 protein CTD PMID:21224054 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GSTM3 mRNA CTD PMID:21224054 NCBI chr 2:195,531,627...195,534,562
Ensembl chr 2:195,531,495...195,534,553
JBrowse link
G H2ax H2A.X variant histone increases expression ISO Monocrotaline results in increased expression of H2AX protein CTD PMID:31154085 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Hmgb1 high mobility group box 1 increases secretion ISO
EXP
Monocrotaline results in increased secretion of HMGB1 protein CTD PMID:31504964 NCBI chr12:5,973,062...5,978,565 JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO
EXP
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HMOX1 mRNA
Monocrotaline results in increased expression of HMOX1 mRNA
liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of HMOX1 mRNA]; liquiritin inhibits the reaction [Monocrotaline results in increased expression of HMOX1 mRNA]
CTD PMID:21224054 PMID:29908794 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPA1L mRNA CTD PMID:21224054 NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPA8 mRNA CTD PMID:21224054 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPB1 mRNA CTD PMID:21224054 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions
affects expression
increases secretion
ISO
EXP
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of HSPD1 mRNA
liquiritigenin inhibits the reaction [Monocrotaline affects the expression of HSPD1 protein]; liquiritin inhibits the reaction [Monocrotaline affects the expression of HSPD1 protein]
Monocrotaline results in increased secretion of HSPD1 protein
CTD PMID:21224054 PMID:31504964 PMID:31589899 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of HSPE1 mRNA CTD PMID:21224054 NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions
increases expression
EXP Quercetin inhibits the reaction [Monocrotaline results in increased expression of HTR2A mRNA] CTD PMID:25460361 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO [Monocrotaline co-treated with 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid] results in decreased expression of ICAM1 mRNA; [TBXA2R protein affects the susceptibility to Monocrotaline] which affects the expression of ICAM1 mRNA CTD PMID:31470032 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein decreases expression
multiple interactions
EXP Monocrotaline results in decreased expression of ID1 mRNA
treprostinil inhibits the reaction [Monocrotaline results in decreased expression of ID1 mRNA]
CTD PMID:20522807 NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419
JBrowse link
G Il10 interleukin 10 multiple interactions
decreases expression
ISO
EXP
[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of IL10 protein
Monocrotaline results in decreased expression of IL10 protein
CTD PMID:21327618 PMID:25051504 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il18 interleukin 18 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL18 mRNA CTD PMID:21224054 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1a interleukin 1 alpha decreases expression EXP Monocrotaline results in decreased expression of IL1A protein CTD PMID:25051504 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases secretion
increases expression
affects expression
ISO
EXP
[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of IL1B protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL1B mRNA
Monocrotaline results in increased secretion of IL1B protein
angiotensin I (1-7) inhibits the reaction [Monocrotaline results in increased expression of IL1B mRNA]; Curcumin analog inhibits the reaction [Monocrotaline results in increased expression of IL1B protein]
Monocrotaline results in increased expression of IL1B mRNA; Monocrotaline results in increased expression of IL1B protein
Monocrotaline affects the expression of IL1B mRNA
CTD PMID:20581171 PMID:21224054 PMID:21327618 PMID:25051504 PMID:31407471 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
increases secretion
decreases expression
ISO
EXP
[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of IL6 protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of IL6 mRNA; TF mRNA affects the reaction [[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of IL6 protein]
angiotensin I (1-7) inhibits the reaction [Monocrotaline results in increased expression of IL6 mRNA]; liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of IL6 mRNA]; liquiritin inhibits the reaction [Monocrotaline results in increased expression of IL6 mRNA]; NCP-2454 inhibits the reaction [Monocrotaline results in increased expression of IL6 protein]
Monocrotaline results in increased expression of IL6 mRNA; Monocrotaline results in increased expression of IL6 protein
Monocrotaline results in increased secretion of IL6 protein
Monocrotaline results in decreased expression of IL6 protein
CTD PMID:20581171 PMID:21224054 PMID:21327618 PMID:25051504 PMID:25275723 More... NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Itgb1 integrin subunit beta 1 increases expression ISO Monocrotaline results in increased expression of ITGB1 mRNA CTD PMID:28818515 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
JBrowse link
G Kcna5 potassium voltage-gated channel subfamily A member 5 decreases expression EXP Monocrotaline results in decreased expression of KCNA5 mRNA CTD PMID:25460361 NCBI chr 4:159,354,689...159,358,173
Ensembl chr 4:159,350,097...159,357,697
JBrowse link
G Kcnb1 potassium voltage-gated channel subfamily B member 1 decreases expression EXP Monocrotaline results in decreased expression of KCNB1 mRNA CTD PMID:25460361 NCBI chr 3:155,820,255...155,913,383
Ensembl chr 3:155,822,963...155,916,194
JBrowse link
G Kdr kinase insert domain receptor multiple interactions
decreases expression
ISO romiplostim inhibits the reaction [Monocrotaline results in decreased expression of KDR mRNA]; THPO protein inhibits the reaction [Monocrotaline results in decreased expression of KDR mRNA] CTD PMID:33122006 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Kif11 kinesin family member 11 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of KIF11 mRNA CTD PMID:33884520 NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766
JBrowse link
G Kif23 kinesin family member 23 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of KIF23 mRNA CTD PMID:33884520 NCBI chr 8:62,397,908...62,425,162
Ensembl chr 8:62,397,948...62,425,072
JBrowse link
G Lep leptin multiple interactions
affects expression
ISO
EXP
[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of LEP protein; TF mRNA affects the reaction [[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of LEP protein]
Monocrotaline affects the expression of LEP protein
CTD PMID:21327618 PMID:25051504 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Lgals3 galectin 3 multiple interactions EXP [Monocrotaline co-treated with LGALS3 protein] inhibits the reaction [[Monocrotaline co-treated with TGFB1] results in decreased expression of MMP9 protein]; [Monocrotaline co-treated with LGALS3 protein] promotes the reaction [[Monocrotaline co-treated with TGFB1] results in increased expression of COL1A1 protein]; [Monocrotaline co-treated with LGALS3 protein] results in decreased expression of MMP9 protein; [Monocrotaline co-treated with LGALS3 protein] results in increased expression of COL1A1 protein; [Monocrotaline co-treated with TGFB1] results in increased expression of LGALS3 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[Monocrotaline co-treated with TGFB1] results in increased expression of LGALS3 protein] CTD PMID:27870162 NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025
JBrowse link
G Limd2 LIM domain containing 2 increases expression ISO Monocrotaline results in increased expression of LIMD2 mRNA CTD PMID:28818515 NCBI chr10:91,090,279...91,092,772
Ensembl chr10:91,090,280...91,092,775
JBrowse link
G Lyve1 lymphatic vessel endothelial hyaluronan receptor 1 decreases expression ISO Monocrotaline results in decreased expression of LYVE1 protein CTD PMID:31470032 NCBI chr 1:164,962,872...164,976,309
Ensembl chr 1:164,962,872...164,976,309
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
EXP Monocrotaline results in increased phosphorylation of MAPK1 protein
magnolol inhibits the reaction [Monocrotaline results in increased phosphorylation of MAPK1 protein]
CTD PMID:30466619 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
EXP Monocrotaline results in increased phosphorylation of MAPK3 protein
magnolol inhibits the reaction [Monocrotaline results in increased phosphorylation of MAPK3 protein]
CTD PMID:30466619 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mdc1 mediator of DNA damage checkpoint 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of MDC1 mRNA CTD PMID:33884520 NCBI chr20:2,893,693...2,912,394
Ensembl chr20:2,895,505...2,910,240
JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of MDM2 mRNA CTD PMID:21224054 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Mgat5b alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B increases expression ISO Monocrotaline results in increased expression of MGAT5B mRNA CTD PMID:28818515 NCBI chr10:102,120,757...102,190,235
Ensembl chr10:102,120,445...102,190,233
JBrowse link
G Mir122 microRNA 122 increases expression ISO Monocrotaline results in increased expression of MIR122 mRNA CTD PMID:28844483 NCBI chr18:58,758,703...58,758,787 JBrowse link
G Mir132 microRNA 132 decreases expression ISO Monocrotaline results in decreased expression of MIR132 mRNA CTD PMID:28818515 NCBI chr10:60,023,696...60,023,796
Ensembl chr10:60,023,696...60,023,796
JBrowse link
G Mir138-1 microRNA 138-1 decreases expression ISO Monocrotaline results in decreased expression of MIR138-1 mRNA CTD PMID:28818515 NCBI chr 8:122,300,966...122,301,064
Ensembl chr 8:122,300,966...122,301,064
JBrowse link
G Mir2964 microRNA 2964 decreases expression ISO Monocrotaline results in decreased expression of MIR219B mRNA CTD PMID:28818515 NCBI chr 3:13,118,623...13,118,722
Ensembl chr 3:13,118,623...13,118,722
JBrowse link
G Mir301b microRNA 301b decreases expression ISO Monocrotaline results in decreased expression of MIR301B mRNA CTD PMID:28818515 NCBI chr11:83,879,816...83,879,893
Ensembl chr11:83,879,816...83,879,893
JBrowse link
G Mir370 microRNA 370 decreases expression ISO Monocrotaline results in decreased expression of MIR370 mRNA CTD PMID:28818515 NCBI chr 6:128,572,257...128,572,335
Ensembl chr 6:128,572,257...128,572,335
JBrowse link
G Mir410 microRNA 410 decreases expression ISO Monocrotaline results in decreased expression of MIR410 mRNA CTD PMID:28818515 NCBI chr 6:128,758,358...128,758,433
Ensembl chr 6:128,758,354...128,758,434
JBrowse link
G Mir489 microRNA 489 decreases expression ISO Monocrotaline results in decreased expression of MIR489 mRNA CTD PMID:28818515 NCBI chr 4:31,693,355...31,693,460
Ensembl chr 4:31,693,355...31,693,460
JBrowse link
G Mir500 microRNA 500 decreases expression ISO Monocrotaline results in decreased expression of MIR500 mRNA CTD PMID:28818515 NCBI chr  X:15,258,778...15,258,857
Ensembl chr  X:15,258,768...15,258,859
JBrowse link
G Mir551b microRNA 551b decreases expression ISO Monocrotaline results in decreased expression of MIR551B mRNA CTD PMID:28818515 NCBI chr 2:113,989,203...113,989,300
Ensembl chr 2:113,989,203...113,989,300
JBrowse link
G Mir93 microRNA 93 decreases expression ISO Monocrotaline results in decreased expression of MIR93 mRNA CTD PMID:28818515 NCBI chr12:17,043,135...17,043,221
Ensembl chr12:17,043,135...17,043,221
JBrowse link
G Mir98 microRNA 98 decreases expression ISO Monocrotaline results in decreased expression of MIR98 mRNA CTD PMID:28818515 NCBI chr  X:20,981,235...20,981,342
Ensembl chr  X:20,981,235...20,981,342
JBrowse link
G Mirlet7b microRNA let-7b decreases expression ISO Monocrotaline results in decreased expression of MIRLET7B mRNA CTD PMID:28818515 NCBI chr 7:116,804,186...116,804,270
Ensembl chr 7:116,804,186...116,804,270
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC gene mutant form] results in increased expression of MKI67 protein CTD PMID:21224054 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mlh1 mutL homolog 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of MLH1 mRNA CTD PMID:33884520 NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617
JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression
multiple interactions
EXP
ISO
Monocrotaline results in increased expression of MMP2 mRNA
[Monocrotaline co-treated with 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid] results in decreased expression of MMP2 mRNA; [TBXA2R protein affects the susceptibility to Monocrotaline] which affects the expression of MMP2 mRNA
Simvastatin inhibits the reaction [Monocrotaline results in increased expression of MMP2 mRNA]
CTD PMID:22022327 PMID:31470032 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
increases expression
EXP
ISO
[Monocrotaline co-treated with LGALS3 protein] inhibits the reaction [[Monocrotaline co-treated with TGFB1] results in decreased expression of MMP9 protein]; [Monocrotaline co-treated with LGALS3 protein] results in decreased expression of MMP9 protein; [Monocrotaline co-treated with TGFB1] results in decreased expression of MMP9 protein; liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of MMP9 protein]; liquiritin inhibits the reaction [Monocrotaline results in increased expression of MMP9 protein]
Monocrotaline results in increased expression of MMP9 mRNA; Monocrotaline results in increased expression of MMP9 protein
[TBXA2R protein affects the susceptibility to Monocrotaline] which affects the expression of MMP9 mRNA; romiplostim inhibits the reaction [Monocrotaline results in increased expression of MMP9 mRNA]; THPO protein inhibits the reaction [Monocrotaline results in increased expression of MMP9 mRNA]; TLR4 gene mutant form inhibits the reaction [Monocrotaline results in increased expression of MMP9 protein]
CTD PMID:27870162 PMID:29908794 PMID:31470032 PMID:31504964 PMID:31589899 More... NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpo myeloperoxidase increases activity
multiple interactions
EXP
ISO
Monocrotaline results in increased activity of MPO protein
liquiritigenin inhibits the reaction [Monocrotaline results in increased activity of MPO protein]; liquiritin inhibits the reaction [Monocrotaline results in increased activity of MPO protein]
TLR4 gene mutant form inhibits the reaction [Monocrotaline results in increased activity of MPO protein]
CTD PMID:31504964 PMID:31589899 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of MRE11 mRNA CTD PMID:33884520 NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279
JBrowse link
G Msh2 mutS homolog 2 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of MSH2 mRNA CTD PMID:33884520 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938
JBrowse link
G Msh6 mutS homolog 6 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of MSH6 mRNA CTD PMID:33884520 NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor decreases response to substance ISO MYD88 gene mutant form results in decreased susceptibility to Monocrotaline CTD PMID:31504964 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
JBrowse link
G Myh6 myosin heavy chain 6 decreases expression EXP Monocrotaline results in decreased expression of MYH6 mRNA CTD PMID:16936438 NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720
JBrowse link
G Myh7 myosin heavy chain 7 increases expression EXP Monocrotaline results in increased expression of MYH7 mRNA CTD PMID:16936438 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
affects response to substance
decreases expression
EXP
ISO
liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of NFE2L2 mRNA]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of NFE2L2 mRNA]
NFE2L2 gene mutant form affects the susceptibility to Monocrotaline
CTD PMID:29908794 PMID:31504964 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
ISO
EXP
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of NOS2 mRNA
4-chlorobenzyltetrahydroberberine inhibits the reaction [Monocrotaline results in increased expression of NOS2 mRNA]; liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of NOS2 mRNA]; liquiritin inhibits the reaction [Monocrotaline results in increased expression of NOS2 mRNA]; magnolol inhibits the reaction [Monocrotaline results in increased expression of NOS2 protein]; Quercetin inhibits the reaction [Monocrotaline results in increased expression of NOS2 mRNA]; Simvastatin inhibits the reaction [Monocrotaline results in increased expression of NOS2 mRNA]
Monocrotaline results in increased expression of NOS2 mRNA; Monocrotaline results in increased expression of NOS2 protein
CTD PMID:16225752 PMID:21224054 PMID:22022327 PMID:25460361 PMID:30466619 More... NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 decreases activity
multiple interactions
decreases expression
increases expression
EXP Monocrotaline results in decreased activity of NOS3 protein
4-chlorobenzyltetrahydroberberine inhibits the reaction [Monocrotaline results in decreased activity of NOS3 protein]; 4-chlorobenzyltetrahydroberberine inhibits the reaction [Monocrotaline results in increased expression of NOS3 mRNA]; magnolol inhibits the reaction [Monocrotaline results in decreased expression of NOS3 protein]; Quercetin inhibits the reaction [Monocrotaline results in decreased expression of NOS3 mRNA]; Simvastatin inhibits the reaction [Monocrotaline results in increased expression of NOS3 mRNA]
Monocrotaline results in decreased expression of NOS3 mRNA; Monocrotaline results in decreased expression of NOS3 protein
CTD PMID:16225752 PMID:22022327 PMID:25460361 PMID:30466619 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nox1 NADPH oxidase 1 increases expression EXP Monocrotaline results in increased expression of NOX1 mRNA CTD PMID:24947524 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236
JBrowse link
G Nox4 NADPH oxidase 4 increases expression EXP Monocrotaline results in increased expression of NOX4 mRNA; Monocrotaline results in increased expression of NOX4 protein CTD PMID:24835767 PMID:24947524 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
JBrowse link
G Nppa natriuretic peptide A increases expression EXP Monocrotaline results in increased expression of NPPA mRNA CTD PMID:16936438 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Nppb natriuretic peptide B increases expression EXP Monocrotaline results in increased expression of NPPB mRNA; Monocrotaline results in increased expression of NPPB protein CTD PMID:16936438 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 decreases expression
increases expression
multiple interactions
EXP Monocrotaline results in decreased expression of NQO1 mRNA
Monocrotaline results in increased expression of NQO1 protein
liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of NQO1 mRNA]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of NQO1 mRNA]
CTD PMID:29908794 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions
ISO Monocrotaline results in increased activity of NR1I2 protein
[Monocrotaline results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; Dihydrotestosterone inhibits the reaction [[Monocrotaline results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA]; Dihydrotestosterone inhibits the reaction [Monocrotaline results in increased activity of NR1I2 protein]; Flutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [[Monocrotaline results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA]]; Flutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [Monocrotaline results in increased activity of NR1I2 protein]]
CTD PMID:32682830 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of PCNA mRNA CTD PMID:33884520 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 decreases expression
multiple interactions
ISO Monocrotaline results in decreased expression of PECAM1 mRNA; Monocrotaline results in decreased expression of PECAM1 protein
romiplostim inhibits the reaction [Monocrotaline results in decreased expression of PECAM1 mRNA]; TBXA2R protein affects the reaction [Monocrotaline results in decreased expression of PECAM1 protein]; THPO protein inhibits the reaction [Monocrotaline results in decreased expression of PECAM1 mRNA]
CTD PMID:31470032 PMID:33122006 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
JBrowse link
G Phf10 PHD finger protein 10 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PHF10 mRNA CTD PMID:33884520 NCBI chr 1:55,952,249...55,968,994
Ensembl chr 1:55,952,253...55,969,038
JBrowse link
G Pigl phosphatidylinositol glycan anchor biosynthesis, class L decreases expression ISO Monocrotaline results in decreased expression of PIGL mRNA CTD PMID:28818515 NCBI chr10:47,142,160...47,199,892
Ensembl chr10:47,141,780...47,200,145
JBrowse link
G Pkmyt1 protein kinase, membrane associated tyrosine/threonine 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PKMYT1 mRNA CTD PMID:33884520 NCBI chr10:12,748,221...12,758,995
Ensembl chr10:12,748,237...12,758,995
JBrowse link
G Pknox1 PBX/knotted 1 homeobox 1 decreases expression ISO Monocrotaline results in decreased expression of PKNOX1 mRNA CTD PMID:28818515 NCBI chr20:9,662,866...9,705,030
Ensembl chr20:9,662,899...9,703,727
JBrowse link
G Plk1 polo-like kinase 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PLK1 mRNA CTD PMID:33884520 NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400
JBrowse link
G Plk2 polo-like kinase 2 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of PLK2 mRNA CTD PMID:33884520 NCBI chr 2:41,969,176...41,974,945
Ensembl chr 2:41,969,176...41,974,947
JBrowse link
G Plk3 polo-like kinase 3 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of PLK3 mRNA CTD PMID:33884520 NCBI chr 5:130,607,142...130,612,317
Ensembl chr 5:130,607,142...130,612,317
JBrowse link
G Plk4 polo-like kinase 4 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PLK4 mRNA CTD PMID:33884520 NCBI chr 2:123,802,512...123,820,942
Ensembl chr 2:123,802,512...123,820,942
JBrowse link
G Plvap plasmalemma vesicle associated protein decreases expression EXP Monocrotaline results in decreased expression of PLVAP mRNA CTD PMID:24835767 NCBI chr16:18,184,985...18,197,301
Ensembl chr16:18,184,975...18,197,301
JBrowse link
G Por cytochrome p450 oxidoreductase affects metabolic processing ISO POR protein affects the metabolism of Monocrotaline CTD PMID:33033841 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Postn periostin increases expression EXP Monocrotaline results in increased expression of POSTN protein CTD PMID:24947524 NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099
JBrowse link
G Pou2f1 POU class 2 homeobox 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of POU2F1 mRNA CTD PMID:33884520 NCBI chr13:78,120,617...78,263,306
Ensembl chr13:78,130,685...78,263,363
JBrowse link
G Ppm1j protein phosphatase, Mg2+/Mn2+ dependent, 1J multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PPM1J mRNA CTD PMID:33884520 NCBI chr 2:192,278,597...192,283,883
Ensembl chr 2:192,278,517...192,283,882
JBrowse link
G Ppm1l protein phosphatase, Mg2+/Mn2+ dependent, 1L multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PPM1L mRNA CTD PMID:33884520 NCBI chr 2:153,566,653...153,839,434
Ensembl chr 2:153,566,653...153,839,434
JBrowse link
G Ppp2cb protein phosphatase 2 catalytic subunit beta multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of PPP2CB mRNA CTD PMID:33884520 NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576
JBrowse link
G Ppp2r3b protein phosphatase 2, regulatory subunit B'', beta multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PPP2R3B mRNA CTD PMID:33884520 NCBI chr14:88,507...95,750
Ensembl chr14:89,176...95,750
JBrowse link
G Ppp2r5e protein phosphatase 2 regulatory subunit B', epsilon multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of PPP2R5E mRNA CTD PMID:33884520 NCBI chr 6:94,168,846...94,317,872
Ensembl chr 6:94,168,846...94,317,872
JBrowse link
G Prc1 protein regulator of cytokinesis 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PRC1 mRNA CTD PMID:33884520 NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765
JBrowse link
G Prkar2a protein kinase cAMP-dependent type II regulatory subunit alpha increases expression ISO Monocrotaline results in increased expression of PRKAR2A mRNA CTD PMID:28818515 NCBI chr 8:109,393,189...109,458,832
Ensembl chr 8:109,395,833...109,455,628
JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC gene mutant form] results in increased expression of MKI67 protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CCND1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CHEK2 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP1B1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP2A5 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP2B9 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP4A10 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP4A14 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP7A1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of DNAJA1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of EGR1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FASL mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO4 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of HSPD1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of HSPE1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL18 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL1B mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of RAD50 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of TNFSF10 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of TRADD mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of XRCC4 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of ANXA5 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of BAX mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of BCL2L1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CCNG1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CDKN1A mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CDKN1A protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CXCL10 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP2B10 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP3A11 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP3A4 protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of DDIT3 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of E2F1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GADD45A mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GPX2 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GSTM1 protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GSTM3 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HMOX1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPA1L mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPA8 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPB1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of IL6 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of MDM2 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of NOS2 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of SERPINE1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of UNG mRNA; PRKDC gene mutant form results in increased susceptibility to [Rifampin co-treated with Phenytoin co-treated with Monocrotaline] CTD PMID:21224054 NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952
JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 decreases expression
multiple interactions
EXP Monocrotaline results in decreased expression of PRKG1 protein
Fluoxetine inhibits the reaction [Monocrotaline results in decreased expression of PRKG1 protein]
CTD PMID:21619414 NCBI chr 1:228,409,883...229,638,794 JBrowse link
G Psma1 proteasome 20S subunit alpha 1 increases expression
multiple interactions
EXP Monocrotaline results in increased expression of PSMA1 mRNA
Pentoxifylline inhibits the reaction [Monocrotaline results in increased expression of PSMA1 mRNA]
CTD PMID:18801959 NCBI chr 1:168,442,421...168,453,440
Ensembl chr 1:168,440,936...168,453,472
JBrowse link
G Psma3 proteasome 20S subunit alpha 3 increases expression
multiple interactions
EXP Monocrotaline results in increased expression of PSMA3 mRNA
Pentoxifylline inhibits the reaction [Monocrotaline results in increased expression of PSMA3 mRNA]
CTD PMID:18801959 NCBI chr 6:89,483,741...89,503,775
Ensembl chr 6:89,483,727...89,504,965
JBrowse link
G Psmc2 proteasome 26S subunit, ATPase 2 increases expression EXP Monocrotaline results in increased expression of PSMC2 mRNA CTD PMID:18801959 NCBI chr 4:13,255,851...13,270,102
Ensembl chr 4:13,255,856...13,270,185
JBrowse link
G Psmc6 proteasome 26S subunit, ATPase 6 increases expression
multiple interactions
EXP Monocrotaline results in increased expression of PSMC6 mRNA
Pentoxifylline inhibits the reaction [Monocrotaline results in increased expression of PSMC6 mRNA]
CTD PMID:18801959 NCBI chr15:18,542,585...18,564,057
Ensembl chr15:18,542,563...18,564,055
JBrowse link
G Pttg1 PTTG1 regulator of sister chromatid separation, securin multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PTTG1 mRNA CTD PMID:33884520 NCBI chr10:27,893,466...27,904,965
Ensembl chr10:27,893,689...27,904,837
JBrowse link
G Rad1 RAD1 checkpoint DNA exonuclease multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RAD1 mRNA CTD PMID:33884520 NCBI chr 2:59,461,597...59,469,707
Ensembl chr 2:59,461,607...59,469,689
JBrowse link
G Rad21 RAD21 cohesin complex component multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RAD21 mRNA CTD PMID:33884520 NCBI chr 7:83,287,867...83,314,810
Ensembl chr 7:83,287,870...83,314,817
JBrowse link
G Rad50 RAD50 double strand break repair protein multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of RAD50 mRNA CTD PMID:21224054 NCBI chr10:37,809,353...37,861,309
Ensembl chr10:37,808,726...37,861,396
JBrowse link
G Rbl1 RB transcriptional corepressor like 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RBL1 mRNA CTD PMID:33884520 NCBI chr 3:145,806,160...145,869,434
Ensembl chr 3:145,807,095...145,869,330
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases localization
multiple interactions
increases expression
EXP
ISO
Monocrotaline results in increased localization of RELA protein
liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of RELA protein]; liquiritin inhibits the reaction [Monocrotaline results in increased expression of RELA protein]
TLR4 gene mutant form inhibits the reaction [Monocrotaline results in increased localization of RELA protein]
CTD PMID:31504964 PMID:31589899 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rfc1 replication factor C subunit 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RFC1 mRNA CTD PMID:33884520 NCBI chr14:42,966,279...43,041,372
Ensembl chr14:42,966,324...43,041,370
JBrowse link
G Rfc2 replication factor C subunit 2 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RFC2 mRNA CTD PMID:33884520 NCBI chr12:22,120,449...22,133,576
Ensembl chr12:22,120,010...22,133,557
JBrowse link
G Rfc3 replication factor C subunit 3 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RFC3 mRNA CTD PMID:33884520 NCBI chr12:1,000,987...1,011,778
Ensembl chr12:1,000,994...1,011,778
JBrowse link
G Rfc4 replication factor C subunit 4 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RFC4 mRNA CTD PMID:33884520 NCBI chr11:77,749,642...77,764,123
Ensembl chr11:77,749,638...77,764,122
JBrowse link
G Rfc5 replication factor C subunit 5 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of RFC5 mRNA CTD PMID:33884520 NCBI chr12:39,207,484...39,217,041
Ensembl chr12:39,207,484...39,217,312
JBrowse link
G Rps6 ribosomal protein S6 increases phosphorylation
multiple interactions
EXP Monocrotaline results in increased phosphorylation of RPS6 protein
Quercetin inhibits the reaction [Monocrotaline results in increased phosphorylation of RPS6 protein]
CTD PMID:25460361 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO [Monocrotaline co-treated with 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid] results in decreased expression of SERPINE1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of SERPINE1 mRNA; [TBXA2R protein affects the susceptibility to Monocrotaline] which affects the expression of SERPINE1 mRNA CTD PMID:21224054 PMID:31470032 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Slc19a1 solute carrier family 19 member 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of SLC19A1 mRNA CTD PMID:33884520 NCBI chr20:11,584,410...11,602,429
Ensembl chr20:11,584,411...11,601,972
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions
increases uptake
ISO Monocrotaline inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Quinidine inhibits the reaction [SLC22A1 protein results in increased uptake of Monocrotaline]; tetrahydropalmatine inhibits the reaction [SLC22A1 protein results in increased uptake of Monocrotaline] CTD PMID:23831208 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
JBrowse link
G Slc6a4 solute carrier family 6 member 4 multiple interactions
increases expression
ISO
EXP
Sertraline inhibits the reaction [Monocrotaline results in increased expression of SLC6A4 mRNA]
Monocrotaline results in increased expression of SLC6A4 protein
Atorvastatin inhibits the reaction [Monocrotaline results in increased expression of SLC6A4 protein]
CTD PMID:17042913 PMID:17575010 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
JBrowse link
G Smad1 SMAD family member 1 multiple interactions
decreases phosphorylation
decreases expression
EXP Fluoxetine inhibits the reaction [Monocrotaline results in decreased expression of SMAD1 mRNA]; Fluoxetine inhibits the reaction [Monocrotaline results in decreased phosphorylation of SMAD1 protein] CTD PMID:21619414 NCBI chr19:28,513,130...28,573,665
Ensembl chr19:28,513,131...28,573,651
JBrowse link
G Smarcb1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of SMARCB1 mRNA CTD PMID:33884520 NCBI chr20:12,741,164...12,763,616
Ensembl chr20:12,741,477...12,763,620
JBrowse link
G Smarcc1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of SMARCC1 mRNA CTD PMID:33884520 NCBI chr 8:110,111,097...110,214,727
Ensembl chr 8:110,111,122...110,214,720
JBrowse link
G Smc1a structural maintenance of chromosomes 1A multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of SMC1A mRNA CTD PMID:33884520 NCBI chr  X:21,103,323...21,148,053
Ensembl chr  X:21,103,282...21,148,056
JBrowse link
G Smc3 structural maintenance of chromosomes 3 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of SMC3 mRNA CTD PMID:33884520 NCBI chr 1:252,601,422...252,644,522
Ensembl chr 1:252,601,753...252,644,522
JBrowse link
G Sqstm1 sequestosome 1 increases expression
multiple interactions
EXP Monocrotaline results in increased expression of SQSTM1 protein
liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of SQSTM1 protein]; liquiritin inhibits the reaction [Monocrotaline results in increased expression of SQSTM1 protein]
CTD PMID:29908794 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Stag2 stromal antigen 2 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of STAG2 mRNA CTD PMID:33884520 NCBI chr  X:120,974,687...121,105,677
Ensembl chr  X:120,974,857...121,105,677
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of STAT1 mRNA CTD PMID:33884520 NCBI chr 9:49,419,561...49,459,969 JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
increases phosphorylation
EXP [Monocrotaline co-treated with TGFB1] results in increased phosphorylation of STAT3 protein; NCP-2454 inhibits the reaction [Monocrotaline results in increased phosphorylation of STAT3 protein] CTD PMID:25275723 PMID:27870162 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tbxa2r thromboxane A2 receptor multiple interactions
affects response to substance
increases expression
ISO [TBXA2R protein affects the susceptibility to Monocrotaline] which affects the expression of ICAM1 mRNA; [TBXA2R protein affects the susceptibility to Monocrotaline] which affects the expression of MMP2 mRNA; [TBXA2R protein affects the susceptibility to Monocrotaline] which affects the expression of MMP9 mRNA; [TBXA2R protein affects the susceptibility to Monocrotaline] which affects the expression of SERPINE1 mRNA; [TBXA2R protein affects the susceptibility to Monocrotaline] which results in increased expression of ALT protein; TBXA2R protein affects the reaction [Monocrotaline results in decreased expression of PECAM1 protein]; TBXA2R protein affects the reaction [Monocrotaline results in increased expression of TBXA2R mRNA] CTD PMID:31470032 NCBI chr 7:8,383,347...8,390,753
Ensembl chr 7:8,383,378...8,388,176
JBrowse link
G Tbxas1 thromboxane A synthase 1 increases expression ISO Monocrotaline results in increased expression of TBXAS1 mRNA CTD PMID:31470032 NCBI chr 4:67,664,963...67,837,096
Ensembl chr 4:67,665,007...67,837,096
JBrowse link
G Tf transferrin multiple interactions ISO [Lipopolysaccharides co-treated with Monocrotaline] results in increased expression of TF protein; [Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of TF protein; TF mRNA affects the reaction [[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of IL6 protein]; TF mRNA affects the reaction [[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of LEP protein] CTD PMID:21279329 PMID:21327618 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
JBrowse link
G Tfrc transferrin receptor increases expression ISO Monocrotaline results in increased expression of TFRC mRNA CTD PMID:28818515 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases expression
EXP [Monocrotaline co-treated with LGALS3 protein] inhibits the reaction [[Monocrotaline co-treated with TGFB1] results in decreased expression of MMP9 protein]; [Monocrotaline co-treated with LGALS3 protein] promotes the reaction [[Monocrotaline co-treated with TGFB1] results in increased expression of COL1A1 protein]; [Monocrotaline co-treated with TGFB1] results in decreased expression of MMP9 protein; [Monocrotaline co-treated with TGFB1] results in increased expression of COL1A1 protein; [Monocrotaline co-treated with TGFB1] results in increased expression of FN1 protein; [Monocrotaline co-treated with TGFB1] results in increased expression of LGALS3 protein; [Monocrotaline co-treated with TGFB1] results in increased phosphorylation of STAT3 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[Monocrotaline co-treated with TGFB1] results in increased expression of COL1A1 protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[Monocrotaline co-treated with TGFB1] results in increased expression of FN1 protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[Monocrotaline co-treated with TGFB1] results in increased expression of LGALS3 protein]; NCP-2454 inhibits the reaction [Monocrotaline results in increased expression of TGFB1 protein] CTD PMID:25275723 PMID:27870162 PMID:31734320 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Thpo thrombopoietin decreases response to substance
multiple interactions
ISO THPO protein results in decreased susceptibility to Monocrotaline
THPO protein inhibits the reaction [Monocrotaline results in decreased expression of FLT4 mRNA]; THPO protein inhibits the reaction [Monocrotaline results in decreased expression of KDR mRNA]; THPO protein inhibits the reaction [Monocrotaline results in decreased expression of PECAM1 mRNA]; THPO protein inhibits the reaction [Monocrotaline results in increased expression of MMP9 mRNA]
CTD PMID:33122006 Ensembl chr11:80,182,820...80,188,167 JBrowse link
G Thy1 Thy-1 cell surface antigen increases expression EXP Monocrotaline results in increased expression of THY1 protein CTD PMID:24947524 NCBI chr 8:44,389,495...44,394,688
Ensembl chr 8:44,389,513...44,394,659
JBrowse link
G Ticam1 toll-like receptor adaptor molecule 1 decreases response to substance ISO TICAM1 gene mutant form results in decreased susceptibility to Monocrotaline CTD PMID:31504964 NCBI chr 9:1,102,559...1,115,573 JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression
multiple interactions
EXP Monocrotaline results in increased expression of TIMP1 mRNA
Simvastatin inhibits the reaction [Monocrotaline results in increased expression of TIMP1 mRNA]
CTD PMID:22022327 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tlk1 tousled-like kinase 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of TLK1 mRNA CTD PMID:33884520 NCBI chr 3:55,520,559...55,627,580
Ensembl chr 3:55,503,358...55,691,968
JBrowse link
G Tlr4 toll-like receptor 4 increases expression
multiple interactions
decreases response to substance
EXP
ISO
Monocrotaline results in increased expression of TLR4 protein
liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of TLR4 protein]; liquiritin inhibits the reaction [Monocrotaline results in increased expression of TLR4 protein]
TLR4 gene mutant form results in decreased susceptibility to Monocrotaline
TLR4 gene mutant form inhibits the reaction [Monocrotaline results in increased activity of MPO protein]; TLR4 gene mutant form inhibits the reaction [Monocrotaline results in increased expression of MMP9 protein]; TLR4 gene mutant form inhibits the reaction [Monocrotaline results in increased localization of RELA protein]
CTD PMID:31504964 PMID:31589899 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tmed2 transmembrane p24 trafficking protein 2 increases expression ISO Monocrotaline results in increased expression of TMED2 mRNA CTD PMID:28818515 NCBI chr12:32,052,542...32,061,596
Ensembl chr12:32,052,543...32,071,903
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
increases secretion
decreases expression
ISO
EXP
[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of TNF protein
angiotensin I (1-7) inhibits the reaction [Monocrotaline results in increased expression of TNF mRNA]; Curcumin analog inhibits the reaction [Monocrotaline results in increased expression of TNF protein]
Monocrotaline results in increased expression of TNF mRNA; Monocrotaline results in increased expression of TNF protein
Monocrotaline results in increased secretion of TNF protein
Monocrotaline results in decreased expression of TNF protein
CTD PMID:20581171 PMID:21327618 PMID:25051504 PMID:31407471 PMID:31504964 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of TNFSF10 mRNA CTD PMID:21224054 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
G Tnn tenascin N increases expression EXP Monocrotaline results in increased expression of TNN protein CTD PMID:24947524 NCBI chr13:72,319,160...72,386,362
Ensembl chr13:72,319,155...72,408,156
JBrowse link
G Topbp1 DNA topoisomerase II binding protein 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of TOPBP1 mRNA CTD PMID:33884520 NCBI chr 8:103,887,805...103,931,662
Ensembl chr 8:103,887,865...103,931,674
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of TP53 mRNA CTD PMID:33884520 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tradd TNFRSF1A-associated via death domain multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of TRADD mRNA CTD PMID:21224054 NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638
JBrowse link
G Tubb3 tubulin, beta 3 class III decreases expression EXP Monocrotaline results in decreased expression of TUBB3 protein CTD PMID:21781985 NCBI chr19:51,457,187...51,466,243
Ensembl chr19:51,457,184...51,466,243
JBrowse link
G Txn2 thioredoxin 2 decreases expression
multiple interactions
EXP Monocrotaline results in decreased expression of TXN2 mRNA; Monocrotaline results in decreased expression of TXN2 protein
liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of TXN2 mRNA]; liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of TXN2 protein]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of TXN2 mRNA]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of TXN2 protein]
CTD PMID:29908794 NCBI chr 7:109,496,772...109,510,378
Ensembl chr 7:109,496,761...109,510,359
JBrowse link
G Txnrd1 thioredoxin reductase 1 decreases expression EXP Monocrotaline results in decreased expression of TXNRD1 mRNA CTD PMID:29908794 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
G Txnrd2 thioredoxin reductase 2 decreases expression
multiple interactions
EXP Monocrotaline results in decreased expression of TXNRD2 mRNA; Monocrotaline results in decreased expression of TXNRD2 protein
liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of TXNRD2 mRNA]; liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of TXNRD2 protein]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of TXNRD2 mRNA]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of TXNRD2 protein]
CTD PMID:29908794 NCBI chr11:82,519,996...82,568,156
Ensembl chr11:82,519,999...82,568,156
JBrowse link
G Ube2b ubiquitin-conjugating enzyme E2B increases expression EXP Monocrotaline results in increased expression of UBE2B mRNA CTD PMID:18801959 NCBI chr10:36,248,434...36,263,379
Ensembl chr10:36,248,438...36,264,665
JBrowse link
G Ube2g1 ubiquitin-conjugating enzyme E2G 1 increases expression EXP Monocrotaline results in increased expression of UBE2G1 mRNA CTD PMID:18801959 NCBI chr10:57,225,963...57,306,748
Ensembl chr10:57,225,952...57,308,568
JBrowse link
G Ung uracil-DNA glycosylase multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of UNG mRNA CTD PMID:21224054 NCBI chr12:42,485,276...42,494,217
Ensembl chr12:42,485,276...42,494,206
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression EXP Monocrotaline results in increased expression of VCAM1 protein CTD PMID:25051504 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases expression
ISO
EXP
[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of VEGFA protein
Monocrotaline results in increased expression of VEGFA protein
CTD PMID:21327618 PMID:25051504 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vim vimentin increases expression EXP Monocrotaline results in increased expression of VIM protein CTD PMID:24947524 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Xrcc4 X-ray repair cross complementing 4 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of XRCC4 mRNA CTD PMID:21224054 NCBI chr 2:20,948,464...21,197,705
Ensembl chr 2:20,951,200...21,197,808
JBrowse link
senecionine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression ISO senecionine results in decreased expression of ABCB11 mRNA CTD PMID:26100227 PMID:31606820 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression ISO senecionine results in decreased expression of ABCB1 mRNA CTD PMID:31606820 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B increases expression EXP senecionine results in increased expression of ABCB1B mRNA CTD PMID:32419051 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases expression ISO senecionine results in decreased expression of ABCB4 mRNA CTD PMID:31606820 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression ISO senecionine results in increased expression of ABCC1 mRNA CTD PMID:31606820 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases expression ISO senecionine results in decreased expression of ABCC2 mRNA CTD PMID:26100227 PMID:31606820 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression
decreases expression
EXP
ISO
senecionine results in increased expression of ABCC3 mRNA
senecionine results in decreased expression of ABCC3 mRNA
CTD PMID:24641316 PMID:26100227 PMID:31606820 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 decreases expression ISO senecionine results in decreased expression of ABCC4 mRNA CTD PMID:31606820 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 decreases expression ISO senecionine results in decreased expression of ABCC6 mRNA CTD PMID:26100227 NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464
JBrowse link
G Acsl3 acyl-CoA synthetase long-chain family member 3 decreases expression ISO senecionine results in decreased expression of ACSL3 mRNA CTD PMID:26100227 NCBI chr 9:80,140,996...80,164,636
Ensembl chr 9:80,115,112...80,164,627
JBrowse link
G Acsm3 acyl-CoA synthetase medium-chain family member 3 decreases expression ISO senecionine results in decreased expression of ACSM3 mRNA CTD PMID:26100227 NCBI chr 1:174,133,260...174,159,966
Ensembl chr 1:174,133,288...174,160,184
JBrowse link
G Actg2 actin gamma 2, smooth muscle decreases expression EXP senecionine results in decreased expression of ACTG2 mRNA CTD PMID:34185104 NCBI chr 4:116,021,832...116,046,475
Ensembl chr 4:116,021,832...116,046,465
JBrowse link
G Adam8 ADAM metallopeptidase domain 8 increases expression EXP senecionine results in increased expression of ADAM8 mRNA CTD PMID:32419051 NCBI chr 1:194,776,559...194,789,330
Ensembl chr 1:194,770,060...194,788,801
JBrowse link
G Aff3 AF4/FMR2 family, member 3 decreases expression ISO senecionine results in decreased expression of AFF3 mRNA CTD PMID:26100227 NCBI chr 9:40,399,109...40,856,716
Ensembl chr 9:40,404,375...40,857,247
JBrowse link
G Agxt alanine--glyoxylate and serine--pyruvate aminotransferase decreases expression ISO senecionine results in decreased expression of AGXT mRNA CTD PMID:26100227 NCBI chr 9:93,675,384...93,685,337
Ensembl chr 9:93,675,384...93,685,336
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP senecionine results in increased expression of ALDH1A1 mRNA CTD PMID:32419051 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Aldh6a1 aldehyde dehydrogenase 6 family, member A1 increases expression ISO senecionine results in increased expression of ALDH6A1 mRNA CTD PMID:26100227 NCBI chr 6:104,077,975...104,098,636
Ensembl chr 6:104,077,979...104,098,656
JBrowse link
G Aldh8a1 aldehyde dehydrogenase 8 family, member A1 decreases expression ISO senecionine results in decreased expression of ALDH8A1 mRNA CTD PMID:26100227 NCBI chr 1:16,183,940...16,203,385
Ensembl chr 1:16,183,940...16,203,385
JBrowse link
G Ankrd1 ankyrin repeat domain 1 decreases expression EXP senecionine results in decreased expression of ANKRD1 mRNA CTD PMID:34185104 NCBI chr 1:233,815,851...233,834,891
Ensembl chr 1:233,815,851...233,834,919
JBrowse link
G Areg amphiregulin increases expression ISO senecionine results in increased expression of AREG mRNA CTD PMID:26100227 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535
JBrowse link
G Arhgap11a Rho GTPase activating protein 11A increases expression EXP senecionine results in increased expression of ARHGAP11A mRNA CTD PMID:32419051 NCBI chr 3:100,590,865...100,607,146
Ensembl chr 3:100,590,865...100,607,559
JBrowse link
G Atad2 ATPase family, AAA domain containing 2 increases expression EXP senecionine results in increased expression of ATAD2 mRNA CTD PMID:32419051 NCBI chr 7:89,634,123...89,676,738
Ensembl chr 7:89,634,123...89,676,738
JBrowse link
G Axin2 axin 2 decreases expression ISO senecionine results in decreased expression of AXIN2 mRNA CTD PMID:31606820 NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231
JBrowse link
G Baat bile acid CoA:amino acid N-acyltransferase decreases expression EXP
ISO
senecionine results in decreased expression of BAAT mRNA CTD PMID:24641316 PMID:26100227 NCBI chr 5:63,851,668...63,860,641
Ensembl chr 5:63,850,705...63,860,685
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO senecionine results in decreased expression of BCL2L1 protein CTD PMID:29458164 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G C3ar1 complement C3a receptor 1 increases expression EXP senecionine results in increased expression of C3AR1 mRNA CTD PMID:34185104 NCBI chr 4:156,074,747...156,084,680
Ensembl chr 4:156,075,389...156,084,701
JBrowse link
G Casp12 caspase 12 increases expression EXP senecionine results in increased expression of CASP12 mRNA CTD PMID:32419051 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Casp3 caspase 3 multiple interactions ISO senecionine results in increased activity of and results in increased cleavage of CASP3 protein CTD PMID:29458164 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions ISO senecionine results in increased activity of and results in increased cleavage of CASP8 protein CTD PMID:29458164 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity ISO senecionine results in increased activity of CASP9 protein CTD PMID:29458164 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccna2 cyclin A2 increases expression EXP senecionine results in increased expression of CCNA2 mRNA CTD PMID:32419051 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccne2 cyclin E2 increases expression EXP senecionine results in increased expression of CCNE2 mRNA CTD PMID:32419051 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
JBrowse link
G Ccng1 cyclin G1 increases expression EXP senecionine results in increased expression of CCNG1 mRNA CTD PMID:32419051 NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression EXP senecionine results in increased expression of CDKN1A mRNA CTD PMID:32419051 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cenpq centromere protein Q increases expression EXP senecionine results in increased expression of CENPQ mRNA CTD PMID:32419051 NCBI chr 9:19,957,040...19,972,807 JBrowse link
G Cenpw centromere protein W increases expression EXP senecionine results in increased expression of CENPW mRNA CTD PMID:32419051 NCBI chr 1:27,525,324...27,530,464
Ensembl chr 1:27,525,324...27,530,464
JBrowse link
G Ckap2 cytoskeleton associated protein 2 increases expression EXP senecionine results in increased expression of CKAP2 mRNA CTD PMID:32419051 NCBI chr16:69,839,668...69,864,852
Ensembl chr16:69,839,630...69,864,913
JBrowse link
G Ckmt2 creatine kinase, mitochondrial 2 decreases expression EXP senecionine results in decreased expression of CKMT2 mRNA CTD PMID:34185104 NCBI chr 2:23,079,920...23,110,518
Ensembl chr 2:23,079,918...23,110,430
JBrowse link
G Clec4a3 C-type lectin domain family 4, member A3 increases expression EXP senecionine results in increased expression of CLEC4A1 mRNA CTD PMID:34185104 NCBI chr 4:156,214,030...156,224,818
Ensembl chr 4:156,214,718...156,224,817
JBrowse link
G Clec4f C-type lectin domain family 4, member F decreases expression EXP senecionine results in decreased expression of CLEC4F mRNA CTD PMID:32419051 NCBI chr 4:116,129,023...116,138,744
Ensembl chr 4:116,129,023...116,138,775
JBrowse link
G Csf1r colony stimulating factor 1 receptor decreases expression EXP senecionine results in decreased expression of CSF1R mRNA CTD PMID:32419051 NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 increases expression ISO senecionine results in increased expression of CYP11A1 mRNA CTD PMID:26100227 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO senecionine results in increased expression of CYP1A1 mRNA CTD PMID:26100227 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
decreases expression
ISO senecionine results in increased expression of CYP1A2 mRNA
senecionine results in decreased expression of CYP1A2 mRNA
CTD PMID:26100227 PMID:31606820 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression ISO senecionine results in increased expression of CYP1B1 mRNA CTD PMID:26100227 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 increases expression ISO senecionine results in increased expression of CYP2A13 mRNA CTD PMID:26100227 NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 affects expression ISO senecionine affects the expression of CYP2B10 mRNA CTD PMID:31606820 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO senecionine results in increased expression of CYP2B6 mRNA CTD PMID:26100227 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 decreases expression ISO senecionine results in decreased expression of CYP2C18 mRNA CTD PMID:26100227 NCBI chr 1:236,873,967...236,936,238
Ensembl chr 1:236,873,967...236,936,238
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression
decreases expression
ISO senecionine results in increased expression of CYP2E1 mRNA
senecionine results in decreased expression of CYP2E1 mRNA
CTD PMID:26100227 PMID:31606820 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a18 cytochrome P450, family 3, subfamily a, polypeptide 18 increases expression ISO senecionine results in increased expression of CYP3A43 mRNA CTD PMID:26100227 NCBI chr12:8,880,528...8,930,382
Ensembl chr12:8,880,528...8,930,381
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO senecionine results in increased expression of CYP3A4 mRNA CTD PMID:26100227 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 decreases expression ISO senecionine results in decreased expression of CYP3A5 mRNA CTD PMID:26100227 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Cyp4f1 cytochrome P450, family 4, subfamily f, polypeptide 1 decreases expression ISO senecionine results in decreased expression of CYP4F12 mRNA CTD PMID:26100227 NCBI chr 7:12,010,850...12,022,497
Ensembl chr 7:12,010,852...12,022,046
JBrowse link
G Cyp4f40 cytochrome P450, family 4, subfamily f, polypeptide 40 increases expression ISO senecionine results in increased expression of CYP4F11 mRNA CTD PMID:26100227 NCBI chr 7:11,691,648...11,707,437
Ensembl chr 7:11,692,086...11,706,229
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression EXP
ISO
senecionine results in decreased expression of CYP7A1 mRNA CTD PMID:24641316 PMID:26100227 PMID:31606820 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression ISO senecionine results in decreased expression of CYP8B1 mRNA CTD PMID:26100227 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
JBrowse link
G Cyria CYFIP related Rac1 interactor A increases expression EXP senecionine results in increased expression of CYRIA mRNA CTD PMID:32419051 NCBI chr 6:35,045,208...35,150,669
Ensembl chr 6:35,045,208...35,150,668
JBrowse link
G Ddias DNA damage-induced apoptosis suppressor increases expression EXP senecionine results in increased expression of DDIAS mRNA CTD PMID:32419051 NCBI chr 1:146,906,150...146,930,462
Ensembl chr 1:146,906,154...146,930,462
JBrowse link
G Dhrs2 dehydrogenase/reductase 2 increases expression ISO senecionine results in increased expression of DHRS2 mRNA CTD PMID:26100227 NCBI chr15:28,688,881...28,703,646
Ensembl chr15:28,688,940...28,703,644
JBrowse link
G Dhrs9 dehydrogenase/reductase 9 increases expression ISO senecionine results in increased expression of DHRS9 mRNA CTD PMID:26100227 NCBI chr 3:54,147,834...54,170,052
Ensembl chr 3:54,147,803...54,220,241
JBrowse link
G Diaph3 diaphanous-related formin 3 increases expression EXP senecionine results in increased expression of DIAPH3 mRNA CTD PMID:32419051 NCBI chr15:62,543,375...63,013,060
Ensembl chr15:62,543,375...63,012,975
JBrowse link
G Dlgap5 DLG associated protein 5 increases expression EXP senecionine results in increased expression of DLGAP5 mRNA CTD PMID:32419051 NCBI chr15:20,633,964...20,664,569
Ensembl chr15:20,633,966...20,664,518
JBrowse link
G Dpyd dihydropyrimidine dehydrogenase decreases expression ISO senecionine results in decreased expression of DPYD mRNA CTD PMID:26100227 NCBI chr 2:206,609,043...207,474,982
Ensembl chr 2:206,609,122...207,474,982
JBrowse link
G Dtl denticleless E3 ubiquitin protein ligase homolog increases expression EXP senecionine results in increased expression of DTL mRNA CTD PMID:32419051 NCBI chr13:103,115,810...103,155,029
Ensembl chr13:103,117,186...103,154,890
JBrowse link
G Eda2r ectodysplasin A2 receptor increases expression EXP senecionine results in increased expression of EDA2R mRNA CTD PMID:32419051 NCBI chr  X:62,224,763...62,269,344
Ensembl chr  X:62,228,229...62,269,268
JBrowse link
G Emilin2 elastin microfibril interfacer 2 increases expression EXP senecionine results in increased expression of EMILIN2 mRNA CTD PMID:34185104 NCBI chr 9:111,160,708...111,220,463
Ensembl chr 9:111,160,712...111,220,352
JBrowse link
G Ephx2 epoxide hydrolase 2 decreases expression ISO senecionine results in decreased expression of EPHX2 mRNA CTD PMID:26100227 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
JBrowse link
G Esco2 establishment of sister chromatid cohesion N-acetyltransferase 2 increases expression EXP senecionine results in increased expression of ESCO2 mRNA CTD PMID:32419051 NCBI chr15:40,034,566...40,052,295
Ensembl chr15:40,034,568...40,055,306
JBrowse link
G Ethe1 ETHE1, persulfide dioxygenase decreases expression EXP senecionine results in decreased expression of ETHE1 mRNA CTD PMID:32419051 NCBI chr 1:80,184,037...80,199,092
Ensembl chr 1:80,183,894...80,199,052
JBrowse link
G Fancd2 FA complementation group D2 increases expression EXP senecionine results in increased expression of FANCD2 mRNA CTD PMID:32419051 NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO
EXP
senecionine metabolite results in increased expression of FAS mRNA
senecionine results in increased expression of FAS mRNA
CTD PMID:30465738 PMID:32419051 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Fcgr3a Fc gamma receptor IIIa increases expression EXP senecionine results in increased expression of FCGR3A mRNA CTD PMID:34185104 NCBI chr13:83,249,905...83,259,921
Ensembl chr13:83,249,872...83,259,921
JBrowse link
G Fmo4 flavin containing dimethylaniline monoxygenase 4 decreases expression ISO senecionine results in decreased expression of FMO4 mRNA CTD PMID:26100227 NCBI chr13:75,154,683...75,172,932
Ensembl chr13:75,154,684...75,172,874
JBrowse link
G Fmo5 flavin containing dimethylaniline monoxygenase 5 decreases expression ISO senecionine results in decreased expression of FMO5 mRNA CTD PMID:26100227 NCBI chr 2:185,197,184...185,249,699
Ensembl chr 2:185,222,204...185,249,693
JBrowse link
G Gem GTP binding protein overexpressed in skeletal muscle increases expression ISO senecionine results in increased expression of GEM mRNA CTD PMID:26100227 NCBI chr 5:25,214,309...25,225,222
Ensembl chr 5:25,214,309...25,225,222
JBrowse link
G Gls glutaminase increases expression ISO senecionine results in increased expression of GLS mRNA CTD PMID:26100227 NCBI chr 9:49,344,616...49,416,900
Ensembl chr 9:49,344,781...49,416,900
JBrowse link
G Glyat glycine-N-acyltransferase decreases expression ISO senecionine results in decreased expression of GLYAT mRNA CTD PMID:26100227 NCBI chr 1:209,704,178...209,724,949
Ensembl chr 1:209,704,268...209,724,942
JBrowse link
G Gnmt glycine N-methyltransferase increases expression ISO senecionine results in increased expression of GNMT mRNA CTD PMID:26100227 NCBI chr 9:14,254,675...14,258,028
Ensembl chr 9:14,254,675...14,258,434
JBrowse link
G Gpc1 glypican 1 decreases expression EXP senecionine results in decreased expression of GPC1 mRNA CTD PMID:34185104 NCBI chr 9:93,396,234...93,424,047
Ensembl chr 9:93,396,234...93,424,047
JBrowse link
G Gphn gephyrin decreases expression ISO senecionine results in decreased expression of GPHN mRNA CTD PMID:26100227 NCBI chr 6:96,954,365...97,483,617
Ensembl chr 6:96,892,148...97,483,612
JBrowse link
G Gprc5a G protein-coupled receptor, class C, group 5, member A increases expression ISO senecionine results in increased expression of GPRC5A mRNA CTD PMID:26100227 NCBI chr 4:167,903,542...167,922,276
Ensembl chr 4:167,903,542...167,922,260
JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity
increases expression
multiple interactions
EXP
ISO
senecionine results in increased activity of GPT protein
senecionine results in increased expression of GPT protein
POR protein affects the reaction [senecionine results in increased expression of GPT protein]
CTD PMID:24641316 PMID:31606820 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 increases expression EXP senecionine results in increased expression of GRIA3 mRNA CTD PMID:32419051 NCBI chr  X:120,238,515...120,504,106
Ensembl chr  X:120,238,534...120,504,096
JBrowse link
G Gsta4 glutathione S-transferase alpha 4 decreases expression ISO senecionine results in decreased expression of GSTA4 mRNA CTD PMID:26100227 NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182
JBrowse link
G Gstt1 glutathione S-transferase theta 1 decreases expression ISO senecionine results in decreased expression of GSTT1 mRNA CTD PMID:26100227 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
JBrowse link
G Gzma granzyme A decreases expression EXP senecionine results in decreased expression of GZMA mRNA CTD PMID:32419051 NCBI chr 2:44,740,638...44,752,471
Ensembl chr 2:44,740,569...44,752,493
JBrowse link
G H2ax H2A.X variant histone increases expression ISO senecionine results in increased expression of H2AX protein CTD PMID:31154085 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Herc6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 increases expression EXP senecionine results in increased expression of HERC6 mRNA CTD PMID:32419051 NCBI chr 4:87,524,470...87,566,895
Ensembl chr 4:87,524,493...87,581,744
JBrowse link
G Hmmr hyaluronan-mediated motility receptor increases expression EXP senecionine results in increased expression of HMMR mRNA CTD PMID:32419051 NCBI chr10:25,132,933...25,163,029
Ensembl chr10:25,132,977...25,163,060
JBrowse link
G Hnmt histamine N-methyltransferase decreases expression ISO senecionine results in decreased expression of HNMT mRNA CTD PMID:26100227 NCBI chr 3:6,591,804...6,623,821
Ensembl chr 3:6,591,463...6,624,012
JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO senecionine results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Ifit2 interferon-induced protein with tetratricopeptide repeats 2 increases expression EXP senecionine results in increased expression of IFIT2 mRNA CTD PMID:32419051 NCBI chr 1:232,102,570...232,108,638
Ensembl chr 1:232,102,570...232,108,635
JBrowse link
G Il11 interleukin 11 increases expression ISO senecionine metabolite results in increased expression of IL11 mRNA CTD PMID:30465738 NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129
JBrowse link
G Il17rd interleukin 17 receptor D increases expression EXP senecionine results in increased expression of IL17RD mRNA CTD PMID:32419051 NCBI chr16:2,228,467...2,295,126
Ensembl chr16:2,228,287...2,292,556
JBrowse link
G Il1b interleukin 1 beta increases expression ISO senecionine metabolite results in increased expression of IL1B mRNA CTD PMID:30465738 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Inmt indolethylamine N-methyltransferase decreases expression EXP senecionine results in decreased expression of INMT mRNA CTD PMID:32419051 NCBI chr 4:84,318,197...84,322,493
Ensembl chr 4:84,318,197...84,322,493
JBrowse link
G Isg20 interferon stimulated exonuclease gene 20 increases expression ISO senecionine results in increased expression of ISG20 mRNA CTD PMID:26100227 NCBI chr 1:132,829,303...132,837,027
Ensembl chr 1:132,815,123...132,837,027
JBrowse link
G Jam3 junctional adhesion molecule 3 increases expression EXP senecionine results in increased expression of JAM3 mRNA CTD PMID:32419051 NCBI chr 8:25,508,461...25,569,306
Ensembl chr 8:25,507,057...25,569,355
JBrowse link
G Kif11 kinesin family member 11 increases expression EXP senecionine results in increased expression of KIF11 mRNA CTD PMID:32419051 NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766
JBrowse link
G Kif18a kinesin family member 18A increases expression EXP senecionine results in increased expression of KIF18A mRNA CTD PMID:32419051 NCBI chr 3:95,764,388...95,824,756
Ensembl chr 3:95,764,388...95,824,582
JBrowse link
G Knl1 kinetochore scaffold 1 increases expression EXP senecionine results in increased expression of KNL1 mRNA CTD PMID:32419051 NCBI chr 3:106,029,627...106,091,915
Ensembl chr 3:106,029,661...106,091,915
JBrowse link
G Kntc1 kinetochore associated 1 increases expression EXP senecionine results in increased expression of KNTC1 mRNA CTD PMID:32419051 NCBI chr12:32,769,020...32,839,617
Ensembl chr12:32,769,020...32,839,561
JBrowse link
G Kyat1 kynurenine aminotransferase 1 decreases expression ISO senecionine results in decreased expression of KYAT1 mRNA CTD PMID:26100227 NCBI chr 3:13,459,598...13,493,308
Ensembl chr 3:13,459,591...13,493,355
JBrowse link
G Lbp lipopolysaccharide binding protein increases expression EXP senecionine results in increased expression of LBP mRNA CTD PMID:32419051 NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586
JBrowse link
G Lcn2 lipocalin 2 increases expression ISO senecionine results in increased expression of LCN2 mRNA CTD PMID:31606820 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Lgr5 leucine rich repeat containing G protein coupled receptor 5 decreases expression ISO senecionine results in decreased expression of LGR5 mRNA CTD PMID:31606820 NCBI chr 7:51,087,059...51,221,882
Ensembl chr 7:51,088,239...51,222,446
JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 increases expression EXP senecionine results in increased expression of MAD2L1 mRNA CTD PMID:32419051 NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470
JBrowse link
G Maff MAF bZIP transcription factor F increases expression ISO senecionine results in increased expression of MAFF mRNA CTD PMID:26100227 NCBI chr 7:110,912,499...110,923,851
Ensembl chr 7:110,912,499...110,923,851
JBrowse link
G Mal mal, T-cell differentiation protein increases expression EXP senecionine results in increased expression of MAL mRNA CTD PMID:34185104 NCBI chr 3:114,864,378...114,888,136
Ensembl chr 3:114,864,378...114,888,136
JBrowse link
G Maoa monoamine oxidase A decreases expression ISO senecionine results in decreased expression of MAOA mRNA CTD PMID:26100227 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593
JBrowse link
G Mastl microtubule associated serine/threonine kinase-like increases expression EXP senecionine results in increased expression of MASTL mRNA CTD PMID:32419051 NCBI chr17:85,250,512...85,287,479
Ensembl chr17:85,251,997...85,287,353
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression EXP senecionine results in increased expression of MCM3 mRNA CTD PMID:32419051 NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314
JBrowse link
G Mcm5 minichromosome maintenance complex component 5 increases expression EXP senecionine results in increased expression of MCM5 mRNA CTD PMID:32419051 NCBI chr19:13,483,030...13,504,389
Ensembl chr19:13,483,066...13,504,389
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases expression EXP senecionine results in increased expression of MGMT mRNA CTD PMID:32419051 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
JBrowse link
G Mki67 marker of proliferation Ki-67 increases expression EXP senecionine results in increased expression of MKI67 mRNA CTD PMID:32419051 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mmp1 matrix metallopeptidase 1 increases expression ISO senecionine results in increased expression of MMP1 mRNA CTD PMID:26100227 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mt2A metallothionein 2A increases expression ISO senecionine results in increased expression of MT2 mRNA CTD PMID:31606820 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
JBrowse link
G Mybl1 MYB proto-oncogene like 1 increases expression EXP senecionine results in increased expression of MYBL1 mRNA CTD PMID:32419051 NCBI chr 5:9,582,905...9,618,179
Ensembl chr 5:9,582,934...9,618,183
JBrowse link
G Mybl2 MYB proto-oncogene like 2 increases expression EXP senecionine results in increased expression of MYBL2 mRNA CTD PMID:32419051 NCBI chr 3:151,705,254...151,733,714
Ensembl chr 3:151,705,288...151,733,708
JBrowse link
G Mybpc3 myosin binding protein C3 decreases expression EXP senecionine results in decreased expression of MYBPC3 mRNA CTD PMID:34185104 NCBI chr 3:77,095,165...77,113,406
Ensembl chr 3:77,095,252...77,113,405
JBrowse link
G Myoz2 myozenin 2 decreases expression EXP senecionine results in decreased expression of MYOZ2 mRNA CTD PMID:34185104 NCBI chr 2:211,141,463...211,168,202
Ensembl chr 2:211,141,463...211,168,221
JBrowse link
G Ncaph non-SMC condensin I complex, subunit H increases expression EXP senecionine results in increased expression of NCAPH mRNA CTD PMID:32419051 NCBI chr 3:114,371,937...114,399,223
Ensembl chr 3:114,371,941...114,399,180
JBrowse link
G Ndc80 NDC80 kinetochore complex component increases expression EXP senecionine results in increased expression of NDC80 mRNA CTD PMID:32419051 NCBI chr 9:111,407,191...111,440,921
Ensembl chr 9:111,407,191...111,440,924
JBrowse link
G Neb nebulin decreases expression ISO senecionine results in decreased expression of NEB mRNA CTD PMID:26100227 NCBI chr 3:36,613,677...36,811,618
Ensembl chr 3:36,613,716...36,811,574
JBrowse link
G Nnmt nicotinamide N-methyltransferase decreases expression ISO senecionine results in decreased expression of NNMT mRNA CTD PMID:26100227 NCBI chr 8:48,928,663...48,947,734
Ensembl chr 8:48,933,598...48,946,655
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO senecionine results in increased expression of NQO1 mRNA CTD PMID:26100227 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases expression EXP
ISO
senecionine results in decreased expression of NR0B2 mRNA CTD PMID:24641316 PMID:31606820 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 decreases expression EXP senecionine results in decreased expression of NR1H4 mRNA CTD PMID:24641316 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 decreases expression ISO senecionine results in decreased expression of NR1I3 mRNA CTD PMID:31606820 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases expression EXP senecionine results in decreased expression of NR3C1 mRNA CTD PMID:32419051 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Nrcam neuronal cell adhesion molecule increases expression EXP senecionine results in increased expression of NRCAM mRNA CTD PMID:32419051 NCBI chr 6:61,402,813...61,698,536
Ensembl chr 6:61,329,863...61,702,992
JBrowse link
G Nrg1 neuregulin 1 increases expression EXP senecionine results in increased expression of NRG1 mRNA CTD PMID:32419051 NCBI chr16:59,250,658...60,303,024
Ensembl chr16:59,250,854...60,296,884
JBrowse link
G Nusap1 nucleolar and spindle associated protein 1 increases expression EXP senecionine results in increased expression of NUSAP1 mRNA CTD PMID:32419051 NCBI chr 3:106,603,273...106,633,624
Ensembl chr 3:106,603,289...106,633,624
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 decreases expression ISO senecionine results in decreased expression of PARP1 protein CTD PMID:29458164 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pclaf PCNA clamp associated factor increases expression EXP senecionine results in increased expression of PCLAF mRNA CTD PMID:32419051 NCBI chr 8:66,420,673...66,432,568
Ensembl chr 8:66,420,587...66,432,994
Ensembl chr 8:66,420,587...66,432,994
JBrowse link
G Pld4 phospholipase D family, member 4 increases expression EXP senecionine results in increased expression of PLD4 mRNA CTD PMID:34185104 NCBI chr 6:131,818,860...131,827,457
Ensembl chr 6:131,818,860...131,826,376
JBrowse link
G Plk4 polo-like kinase 4 increases expression EXP senecionine results in increased expression of PLK4 mRNA CTD PMID:32419051 NCBI chr 2:123,802,512...123,820,942
Ensembl chr 2:123,802,512...123,820,942
JBrowse link
G Pln phospholamban decreases expression EXP senecionine results in decreased expression of PLN mRNA CTD PMID:34185104 NCBI chr20:32,629,537...32,639,559 JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions
affects response to substance
ISO POR protein affects the reaction [senecionine results in increased expression of GPT protein]
POR protein affects the susceptibility to senecionine
CTD PMID:31606820 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Prc1 protein regulator of cytokinesis 1 increases expression EXP senecionine results in increased expression of PRC1 mRNA CTD PMID:32419051 NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765
JBrowse link
G Ptgis prostaglandin I2 synthase decreases expression ISO senecionine metabolite results in decreased expression of PTGIS mRNA; senecionine metabolite results in decreased expression of PTGIS protein CTD PMID:30465738 NCBI chr 3:155,928,564...155,964,228 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO senecionine metabolite results in increased expression of PTGS2 mRNA; senecionine metabolite results in increased expression of PTGS2 protein CTD PMID:30465738 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ptprd protein tyrosine phosphatase, receptor type, D decreases expression ISO senecionine results in decreased expression of PTPRD mRNA CTD PMID:26100227 NCBI chr 5:90,046,993...90,698,977
Ensembl chr 5:90,048,966...92,369,396
JBrowse link
G Rapgef4 Rap guanine nucleotide exchange factor 4 decreases expression ISO senecionine results in decreased expression of RAPGEF4 mRNA CTD PMID:26100227 NCBI chr 3:56,809,388...57,101,332
Ensembl chr 3:56,809,270...57,102,316
JBrowse link
G Rrad RRAD, Ras related glycolysis inhibitor and calcium channel regulator increases expression ISO senecionine results in increased expression of RRAD mRNA CTD PMID:26100227 NCBI chr19:354,184...357,424
Ensembl chr19:354,198...357,417
JBrowse link
G Rrm1 ribonucleotide reductase catalytic subunit M1 increases expression EXP senecionine results in increased expression of RRM1 mRNA CTD PMID:32419051 NCBI chr 1:156,823,960...156,848,262
Ensembl chr 1:156,823,960...156,848,261
JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 increases expression ISO senecionine results in increased expression of SAT1 mRNA CTD PMID:26100227 NCBI chr  X:40,158,354...40,161,641
Ensembl chr  X:40,157,046...40,196,813
JBrowse link
G Sgcb sarcoglycan, beta increases expression EXP senecionine results in increased expression of SGCB mRNA CTD PMID:32419051 NCBI chr14:34,563,614...34,578,614
Ensembl chr14:34,563,608...34,578,583
JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression EXP
ISO
senecionine results in decreased expression of SLC10A1 mRNA CTD PMID:24641316 PMID:31606820 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
JBrowse link
G Slc22a1 solute carrier family 22 member 1 decreases expression ISO senecionine results in decreased expression of SLC22A1 mRNA CTD PMID:31606820 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
JBrowse link
G Slc22a25 solute carrier family 22, member 25 decreases expression ISO senecionine results in decreased expression of SLC22A9 mRNA CTD PMID:26100227 NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085
JBrowse link
G Slc22a7 solute carrier family 22 member 7 decreases expression ISO senecionine results in decreased expression of SLC22A7 mRNA CTD PMID:26100227 PMID:31606820 NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 decreases expression EXP senecionine results in decreased expression of SLCO1A2 mRNA CTD PMID:24641316 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 decreases expression EXP
ISO
senecionine results in decreased expression of SLCO1B2 mRNA
senecionine results in decreased expression of SLCO1B3 mRNA
CTD PMID:24641316 PMID:26100227 PMID:31606820 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
JBrowse link
G Smc2 structural maintenance of chromosomes 2 increases expression EXP senecionine results in increased expression of SMC2 mRNA CTD PMID:32419051 NCBI chr 5:66,806,882...66,853,478
Ensembl chr 5:66,807,011...66,853,242
JBrowse link
G Smc4 structural maintenance of chromosomes 4 increases expression EXP senecionine results in increased expression of SMC4 mRNA CTD PMID:32419051 NCBI chr 2:153,240,243...153,268,722
Ensembl chr 2:153,240,283...153,271,571
JBrowse link
G Smpx small muscle protein, X-linked decreases expression EXP senecionine results in decreased expression of SMPX mRNA CTD PMID:34185104 NCBI chr  X:37,233,209...37,292,266
Ensembl chr  X:37,234,294...37,276,708
JBrowse link
G Srl sarcalumenin decreases expression EXP senecionine results in decreased expression of SRL mRNA CTD PMID:34185104 NCBI chr10:11,033,976...11,078,103
Ensembl chr10:11,034,035...11,078,101
JBrowse link
G Stac3 SH3 and cysteine rich domain 3 decreases expression EXP senecionine results in decreased expression of STAC3 mRNA CTD PMID:32419051 NCBI chr 7:63,343,078...63,350,590
Ensembl chr 7:63,343,186...63,350,589
JBrowse link
G Stc1 stanniocalcin 1 increases expression EXP senecionine results in increased expression of STC1 mRNA CTD PMID:34185104 NCBI chr15:44,299,591...44,311,695
Ensembl chr15:44,299,621...44,310,264
JBrowse link
G Steap4 STEAP4 metalloreductase increases expression EXP senecionine results in increased expression of STEAP4 mRNA CTD PMID:34185104 NCBI chr 4:26,077,182...26,099,859
Ensembl chr 4:26,054,671...26,099,859
JBrowse link
G Stil STIL, centriolar assembly protein increases expression EXP senecionine results in increased expression of STIL mRNA CTD PMID:32419051 NCBI chr 5:128,520,837...128,573,732
Ensembl chr 5:128,520,953...128,573,730
JBrowse link
G Stmn1 stathmin 1 increases expression EXP senecionine results in increased expression of STMN1 mRNA CTD PMID:32419051 NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154
JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 decreases expression ISO senecionine results in decreased expression of SULT1E1 mRNA CTD PMID:26100227 NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 decreases expression ISO senecionine results in decreased expression of SULT2A1 mRNA CTD PMID:31606820 NCBI chr 1:75,451,178...75,508,142 JBrowse link
G Tcf19 transcription factor 19 increases expression EXP senecionine results in increased expression of TCF19 mRNA CTD PMID:32419051 NCBI chr20:3,218,756...3,222,861
Ensembl chr20:3,218,693...3,223,271
JBrowse link
G Tenm1 teneurin transmembrane protein 1 decreases expression ISO senecionine results in decreased expression of TENM1 mRNA CTD PMID:26100227 NCBI chr  X:121,400,466...122,289,877
Ensembl chr  X:121,403,649...122,290,207
JBrowse link
G Tenm2 teneurin transmembrane protein 2 decreases expression ISO senecionine results in decreased expression of TENM2 mRNA CTD PMID:26100227 NCBI chr10:20,480,662...21,706,415
Ensembl chr10:20,481,854...21,705,597
JBrowse link
G Tlr8 toll-like receptor 8 increases expression EXP senecionine results in increased expression of TLR8 mRNA CTD PMID:34185104 NCBI chr  X:27,091,780...27,116,092
Ensembl chr  X:27,091,778...27,116,549
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B increases expression EXP senecionine results in increased expression of TNFRSF1B mRNA CTD PMID:34185104 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206
JBrowse link
G Tnnc1 troponin C1, slow skeletal and cardiac type decreases expression EXP senecionine results in decreased expression of TNNC1 mRNA CTD PMID:34185104 NCBI chr16:6,400,801...6,405,419
Ensembl chr16:6,402,171...6,405,634
JBrowse link
G Top2a DNA topoisomerase II alpha increases expression EXP senecionine results in increased expression of TOP2A mRNA CTD PMID:32419051 NCBI chr10:83,946,186...83,975,694
Ensembl chr10:83,945,735...83,976,874
JBrowse link
G Tpmt thiopurine S-methyltransferase increases expression ISO senecionine results in increased expression of TPMT mRNA CTD PMID:26100227 NCBI chr17:17,644,088...17,662,709
Ensembl chr17:17,644,173...17,662,709
JBrowse link
G Tpx2 TPX2, microtubule nucleation factor increases expression EXP senecionine results in increased expression of TPX2 mRNA CTD PMID:32419051 NCBI chr 3:141,318,428...141,360,684
Ensembl chr 3:141,318,455...141,360,468
JBrowse link
G Ttk Ttk protein kinase increases expression EXP senecionine results in increased expression of TTK mRNA CTD PMID:32419051 NCBI chr 8:84,754,329...84,792,653
Ensembl chr 8:84,754,315...84,792,651
JBrowse link
G Tyms thymidylate synthetase increases expression EXP senecionine results in increased expression of TYMS mRNA CTD PMID:32419051 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536
JBrowse link
G Uchl3 ubiquitin C-terminal hydrolase L3 increases expression ISO senecionine results in increased expression of UCHL3 mRNA CTD PMID:26100227 NCBI chr15:78,485,304...78,527,355
Ensembl chr15:78,485,315...78,527,355
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glycosylation
multiple interactions
ISO UGT1A4 protein results in increased glycosylation of senecionine
[hecogenin results in decreased activity of UGT1A4 protein] which results in decreased glycosylation of senecionine
CTD PMID:20092275 NCBI chr 9:88,762,250...88,808,465 JBrowse link
G Ugt2a3 UDP glucuronosyltransferase family 2 member A3 decreases expression ISO senecionine results in decreased expression of UGT2A3 mRNA CTD PMID:26100227 NCBI chr14:20,572,825...20,590,295
Ensembl chr14:20,572,808...20,590,729
JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 decreases expression ISO senecionine results in decreased expression of UGT2B1 mRNA CTD PMID:31606820 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
JBrowse link
G Vps13b vacuolar protein sorting 13 homolog B decreases expression ISO senecionine results in decreased expression of VPS13B mRNA CTD PMID:26100227 NCBI chr 7:66,557,862...67,128,429
Ensembl chr 7:66,558,471...67,128,429
JBrowse link
G Zfp367 zinc finger protein 367 increases expression EXP senecionine results in increased expression of ZFP367 mRNA CTD PMID:32419051 NCBI chr17:965,161...984,290
Ensembl chr17:965,161...984,287
JBrowse link
G Zwilch zwilch kinetochore protein increases expression EXP senecionine results in increased expression of ZWILCH mRNA CTD PMID:32419051 NCBI chr 8:64,638,401...64,670,911
Ensembl chr 8:64,637,672...64,675,916
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    chemical entity 19800
      atom 19799
        nonmetal atom 19686
          nitrogen atom 18767
            nitrogen molecular entity 18767
              organonitrogen compound 18544
                organonitrogen heterocyclic compound 17661
                  pyrrolizidine 404
                    pyrrolizidine alkaloid + 404
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      p-block molecular entity 19698
                        carbon group molecular entity 19619
                          organic molecular entity 19609
                            organic molecule 19549
                              organic cyclic compound 19343
                                organic heterocyclic compound 18584
                                  organic heteropolycyclic compound 18043
                                    organic heterobicyclic compound 16859
                                      pyrrolizidine 404
                                        pyrrolizidine alkaloid + 404
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