CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: hepatitis C protease inhibitor
Accession: CHEBI:64924
browse the term
Definition: An inhibitor of hepatitis C protease, an enzyme required for production of proteins needed for viral assembly.
Synonyms: related_synonym: hepatitis C protease inhibitors
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Akt1
AKT serine/threonine kinase 1
decreases phosphorylation
ISO
embelin results in decreased phosphorylation of AKT1 protein
CTD
PMID:24694877
NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
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Atg12
autophagy related 12
multiple interactions
ISO
embelin results in increased cleavage of [ATG12 protein binds to ATG5 protein]
CTD
PMID:28722333
NCBI chr18:40,721,799...40,732,143
Ensembl chr18:40,721,800...40,732,126
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Atg5
autophagy related 5
multiple interactions
ISO
embelin results in increased cleavage of [ATG12 protein binds to ATG5 protein]
CTD
PMID:28722333
NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
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Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
embelin results in increased expression of BAX protein
CTD
PMID:24694877
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
embelin results in decreased expression of BCL2 protein
CTD
PMID:24694877
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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Becn1
beclin 1
increases expression
ISO
embelin results in increased expression of BECN1 protein
CTD
PMID:28722333
NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
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Casp3
caspase 3
increases cleavage multiple interactions increases degradation
ISO
embelin results in increased cleavage of CASP3 protein 3-methyladenine promotes the reaction [embelin results in increased degradation of CASP3 protein]
CTD
PMID:24694877 PMID:28722333
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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Casp9
caspase 9
increases degradation multiple interactions
ISO
embelin results in increased degradation of CASP9 protein 3-methyladenine promotes the reaction [embelin results in increased degradation of CASP9 protein]
CTD
PMID:28722333
NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
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Cat
catalase
multiple interactions
EXP
embelin inhibits the reaction [Paraquat results in decreased expression of CAT protein]
CTD
PMID:32020686
NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
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Ccnd1
cyclin D1
decreases expression
ISO
embelin results in decreased expression of CCND1 protein
CTD
PMID:24694877
NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
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Cdh1
cadherin 1
increases expression
ISO
embelin results in increased expression of CDH1 protein
CTD
PMID:24694877
NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
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Cdk2
cyclin dependent kinase 2
decreases expression
ISO
embelin results in decreased expression of CDK2 protein
CTD
PMID:24694877
NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
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Cdk6
cyclin-dependent kinase 6
decreases expression
ISO
embelin results in decreased expression of CDK6 protein
CTD
PMID:24694877
NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
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Dffa
DNA fragmentation factor subunit alpha
increases cleavage
ISO
embelin results in increased cleavage of DFFA protein
CTD
PMID:28722333
NCBI chr 5:165,922,893...165,935,822
Ensembl chr 5:165,922,915...165,935,821
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Gli1
GLI family zinc finger 1
decreases expression
ISO
embelin results in decreased expression of GLI1 protein
CTD
PMID:24694877
NCBI chr 7:70,620,794...70,633,171
Ensembl chr 7:70,620,766...70,630,338
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Gli2
GLI family zinc finger 2
decreases expression
ISO
embelin results in decreased expression of GLI2 protein
CTD
PMID:24694877
NCBI chr13:34,829,021...35,049,172
Ensembl chr13:34,829,139...35,048,444
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Il1b
interleukin 1 beta
multiple interactions
EXP
embelin inhibits the reaction [Paraquat results in increased expression of IL1B protein]
CTD
PMID:32020686
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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Il6
interleukin 6
multiple interactions
EXP
embelin inhibits the reaction [Paraquat results in increased expression of IL6 protein]
CTD
PMID:32020686
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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Kdr
kinase insert domain receptor
decreases expression
ISO
embelin results in decreased expression of KDR protein
CTD
PMID:24694877
NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
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Mki67
marker of proliferation Ki-67
decreases expression
ISO
embelin results in decreased expression of MKI67 protein
CTD
PMID:24694877
NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
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Mmp2
matrix metallopeptidase 2
decreases expression
ISO
embelin results in decreased expression of MMP2 protein
CTD
PMID:24694877
NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
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Mmp9
matrix metallopeptidase 9
decreases expression
ISO
embelin results in decreased expression of MMP9 protein
CTD
PMID:24694877
NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
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Parp1
poly (ADP-ribose) polymerase 1
increases cleavage multiple interactions
ISO
embelin results in increased cleavage of PARP1 protein 3-methyladenine promotes the reaction [embelin results in increased cleavage of PARP1 protein]
CTD
PMID:24694877 PMID:28722333
NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
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Pcna
proliferating cell nuclear antigen
decreases expression
ISO
embelin results in decreased expression of PCNA protein
CTD
PMID:24694877
NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
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Ptgs2
prostaglandin-endoperoxide synthase 2
decreases expression
ISO
embelin results in decreased expression of PTGS2 protein
CTD
PMID:24694877
NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
EXP
embelin inhibits the reaction [Paraquat results in increased phosphorylation of RELA protein]
CTD
PMID:32020686
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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Snai1
snail family transcriptional repressor 1
decreases expression
ISO
embelin results in decreased expression of SNAI1 protein
CTD
PMID:24694877
NCBI chr 3:164,274,710...164,279,199
Ensembl chr 3:164,274,710...164,279,378
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Snai2
snail family transcriptional repressor 2
decreases expression
ISO
embelin results in decreased expression of SNAI2 protein
CTD
PMID:24694877
NCBI chr11:90,404,421...90,406,730
Ensembl chr11:90,403,333...90,406,797
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Sqstm1
sequestosome 1
increases degradation
ISO
embelin results in increased degradation of SQSTM1 protein
CTD
PMID:28722333
NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
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Tnf
tumor necrosis factor
multiple interactions
EXP
embelin inhibits the reaction [Paraquat results in increased expression of TNF protein]
CTD
PMID:32020686
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 Ensembl chr20:5,189,390...5,192,000
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Tnfrsf10b
TNF receptor superfamily member 10b
increases expression
ISO
embelin results in increased expression of TNFRSF10A protein
CTD
PMID:24694877
NCBI chr15:51,433,853...51,464,215
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Vegfa
vascular endothelial growth factor A
decreases expression
ISO
embelin results in decreased expression of VEGFA protein
CTD
PMID:24694877
NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
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Xiap
X-linked inhibitor of apoptosis
decreases activity increases degradation
ISO
embelin results in decreased activity of XIAP protein embelin results in increased degradation of XIAP protein
CTD
PMID:16339139 PMID:28722333
NCBI chr X:128,409,425...128,455,786
Ensembl chr X:128,409,472...128,453,000
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Zeb1
zinc finger E-box binding homeobox 1
decreases expression
ISO
embelin results in decreased expression of ZEB1 protein
CTD
PMID:24694877
NCBI chr17:54,656,627...54,714,920
Ensembl chr17:54,658,463...54,714,914
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Klrc1
killer cell lectin like receptor C1
decreases expression
ISO
ledipasvir co-treated with sofosbuvir decreases expression of NCR1 protein in natural killer cells
RGD
PMID:31218578
RGD:40400920
NCBI chr 4:163,453,435...163,463,718
Ensembl chr 4:163,458,528...163,463,718
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Ncr1
natural cytotoxicity triggering receptor 1
affects expression
ISO
ledipasvir co-treated sofosbuvir with affects expression of NCR1 protein in natural killer cells
RGD
PMID:31218578
RGD:40400920
NCBI chr 1:73,178,917...73,226,504
Ensembl chr 1:73,179,013...73,226,777
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Klrc1
killer cell lectin like receptor C1
decreases expression
ISO
sofosbuvir co-treated with ledipasvir decreased expression of NCR1 protein in natural killer cells
RGD
PMID:31218578
RGD:40400920
NCBI chr 4:163,453,435...163,463,718
Ensembl chr 4:163,458,528...163,463,718
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Ncr1
natural cytotoxicity triggering receptor 1
affects expression
ISO
sofosbuvir co-treated with ledipasvir affects expression of NCR1 protein in natural killer cells
RGD
PMID:31218578
RGD:40400920
NCBI chr 1:73,178,917...73,226,504
Ensembl chr 1:73,179,013...73,226,777
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Cyp3a62
cytochrome P450, family 3, subfamily a, polypeptide 62
multiple interactions
ISO
telaprevir inhibits the reaction [CYP3A4 protein results in increased metabolism of Simvastatin]
CTD
PMID:24927617
NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
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