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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 2.3.1.20 (diacylglycerol O-acyltransferase) inhibitor
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Accession:CHEBI:64919 term browser browse the term
Definition:An EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor that interferes with the action of diacylglycerol O-acyltransferase (EC 2.3.1.20).
Synonyms:related_synonym: 1,2-diacylglycerol acyltransferase inhibitor;   1,2-diacylglycerol acyltransferase inhibitors;   DGAT inhibitor;   DGAT inhibitors;   EC 2.3.1.20 (diacylglycerol O-acyltransferase) inhibitors;   EC 2.3.1.20 inhibitor;   EC 2.3.1.20 inhibitors;   acyl-CoA:1,2-diacylglycerol O-acyltransferase inhibitor;   acyl-CoA:1,2-diacylglycerol O-acyltransferase inhibitors;   diacylglycerol O-acyltransferase inhibitor;   diacylglycerol O-acyltransferase inhibitors;   diacylglycerol acyltransferase inhibitor;   diacylglycerol acyltransferase inhibitors;   diglyceride O-acyltransferase inhibitor;   diglyceride O-acyltransferase inhibitors;   diglyceride acyltransferase inhibitor;   diglyceride acyltransferase inhibitors;   palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase inhibitor;   palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase inhibitors
 xref: Wikipedia:Dgat


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xanthohumol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc5 ATP binding cassette subfamily C member 5 multiple interactions ISO [xanthohumol binds to and results in decreased activity of ABCC5 protein] which results in decreased export of Hyaluronic Acid; xanthohumol binds to and results in decreased activity of ABCC5 protein; xanthohumol inhibits the reaction [ABCC5 protein results in increased export of Hyaluronic Acid] CTD PMID:23978416 NCBI chr11:84,395,982...84,490,215
Ensembl chr11:84,396,033...84,490,211
JBrowse link
G Akt2 AKT serine/threonine kinase 2 multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of AKT2 mRNA] CTD PMID:23994090 NCBI chr 1:84,400,939...84,451,223
Ensembl chr 1:84,411,726...84,450,162
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated increases activity
increases expression
ISO xanthohumol results in increased activity of ALPL protein
xanthohumol results in increased expression of ALPL mRNA
CTD PMID:16019205 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP xanthohumol inhibits the reaction [Azoxymethane results in decreased expression of BAX protein] CTD PMID:31714664 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO
EXP
xanthohumol results in decreased expression of BCL2; xanthohumol results in decreased expression of BCL2 protein
xanthohumol inhibits the reaction [Azoxymethane results in increased expression of BCL2 protein]
CTD PMID:15995977 PMID:23562496 PMID:26297991 PMID:31714664 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of CAR2 mRNA] CTD PMID:23994090 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases activity
increases activity
ISO
EXP
xanthohumol results in increased cleavage of and results in increased activity of CASP3 protein
xanthohumol inhibits the reaction [Azoxymethane results in decreased expression of CASP3 protein]
xanthohumol results in decreased activity of CASP3 protein
xanthohumol results in increased activity of CASP3 protein
CTD PMID:15995977 PMID:26297991 PMID:27317025 PMID:30240731 PMID:31714664 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity
ISO xanthohumol results in increased cleavage of and results in increased activity of CASP7 protein
xanthohumol results in increased activity of CASP7 protein
CTD PMID:15995977 PMID:30240731 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity
ISO xanthohumol results in increased cleavage of and results in increased activity of CASP8 protein
xanthohumol results in increased activity of CASP8 protein
CTD PMID:15995977 PMID:26297991 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
ISO xanthohumol results in increased cleavage of and results in increased activity of CASP9 protein
xanthohumol results in increased activity of CASP9 protein
CTD PMID:15995977 PMID:26297991 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cbr1 carbonyl reductase 1 multiple interactions ISO xanthohumol inhibits the reaction [CBR1 protein results in increased metabolism of Daunorubicin]; xanthohumol inhibits the reaction [CBR1 protein results in increased reduction of 2,3-hexanedione] CTD PMID:30849340 NCBI chr11:33,813,041...33,815,418
Ensembl chr11:33,845,463...33,847,793
JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions
ISO
EXP
xanthohumol results in decreased expression of CCND1
xanthohumol inhibits the reaction [Azoxymethane results in increased expression of CCND1 protein]
CTD PMID:26297991 PMID:27317025 PMID:31714664 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO xanthohumol results in increased expression of CDKN1A CTD PMID:26297991 PMID:27317025 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions ISO xanthohumol inhibits the reaction [CFTR protein results in increased export of Hyaluronic Acid] CTD PMID:23978416 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Clcn7 chloride voltage-gated channel 7 multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of CLCN7 mRNA] CTD PMID:23994090 NCBI chr10:14,492,844...14,518,167
Ensembl chr10:14,492,844...14,516,894
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO xanthohumol results in decreased activity of and results in decreased phosphorylation of CREB1 protein CTD PMID:27317025 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Cryz crystallin zeta increases activity ISO xanthohumol results in increased activity of CRYZ protein CTD PMID:17590382 NCBI chr 2:260,884,315...260,911,827
Ensembl chr 2:260,884,337...260,911,792
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP xanthohumol inhibits the reaction [Azoxymethane results in decreased phosphorylation of and results in increased activity of CTNNB1 protein] CTD PMID:31714664 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Ctsk cathepsin K multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA] CTD PMID:23994090 NCBI chr 2:196,655,469...196,666,447
Ensembl chr 2:196,655,469...196,666,446
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
increases expression
ISO xanthohumol promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A1 mRNA]
xanthohumol results in decreased activity of CYP1A1 protein
xanthohumol results in increased expression of CYP1A1 mRNA
CTD PMID:22138251 PMID:23503627 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
multiple interactions
ISO xanthohumol results in increased expression of CYP1A2 mRNA
xanthohumol inhibits the reaction [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A2 mRNA]
CTD PMID:22138251 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Dio2 iodothyronine deiodinase 2 decreases activity ISO xanthohumol results in decreased activity of DIO2 protein CTD PMID:30561685 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723
JBrowse link
G Dio3 iodothyronine deiodinase 3 decreases activity ISO xanthohumol results in decreased activity of DIO3 protein CTD PMID:30561685 NCBI chr 6:134,627,278...134,629,139
Ensembl chr 6:134,627,278...134,629,138
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
decreases expression
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [xanthohumol results in decreased expression of ESR1 protein]; xanthohumol promotes the reaction [Estradiol results in decreased expression of ESR1 protein] CTD PMID:32986415 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA] CTD PMID:23994090 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gab2 GRB2-associated binding protein 2 multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of GAB2 mRNA] CTD PMID:23994090 NCBI chr 1:162,082,876...162,283,379
Ensembl chr 1:162,083,030...162,279,727
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases expression
multiple interactions
ISO xanthohumol results in decreased expression of GSTA1 mRNA
[xanthohumol co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] results in increased expression of GSTA1 mRNA
CTD PMID:22138251 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression
multiple interactions
ISO xanthohumol results in increased expression of GSTP1 mRNA; xanthohumol results in increased expression of GSTP1 protein
[indole-3-carbinol co-treated with xanthohumol] results in increased expression of GSTP1 mRNA; [phenethyl isothiocyanate co-treated with xanthohumol] results in increased expression of GSTP1 mRNA; [phenethyl isothiocyanate co-treated with xanthohumol] results in increased expression of GSTP1 protein; [Resveratrol co-treated with xanthohumol] results in increased expression of GSTP1 mRNA
CTD PMID:23085367 PMID:32070777 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Gstt1 glutathione S-transferase theta 1 increases expression ISO xanthohumol results in increased expression of GSTT1 mRNA; xanthohumol results in increased expression of GSTT1 protein CTD PMID:23085367 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO xanthohumol results in increased expression of HMOX1 mRNA; xanthohumol results in increased expression of HMOX1 protein CTD PMID:23085367 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO xanthohumol results in decreased expression of ICAM1 protein CTD PMID:23503627 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [xanthohumol results in increased expression of IL1B protein] CTD PMID:31629901 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 decreases expression ISO xanthohumol results in decreased expression of IL6 mRNA CTD PMID:16019205 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
decreases activity
ISO xanthohumol results in decreased phosphorylation of MAPK1 protein
xanthohumol results in decreased activity of MAPK1 protein
CTD PMID:26297991 PMID:27317025 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases activity
decreases phosphorylation
ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of MAPK3 mRNA]
xanthohumol results in decreased activity of MAPK3 protein
xanthohumol results in decreased phosphorylation of MAPK3 protein
CTD PMID:23994090 PMID:26297991 PMID:27317025 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
ISO xanthohumol results in decreased expression of and results in decreased activity of MMP9 protein
xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 mRNA]
xanthohumol results in decreased expression of MMP9 mRNA
CTD PMID:23562496 PMID:23994090 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions EXP xanthohumol inhibits the reaction [Azoxymethane results in increased expression of MYC protein] CTD PMID:31714664 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Myl2 myosin light chain 2 multiple interactions ISO xanthohumol results in decreased phosphorylation of and results in decreased activity of MYL2 protein CTD PMID:23503627 NCBI chr12:39,951,863...39,959,065
Ensembl chr12:39,951,987...39,958,239
JBrowse link
G Nat2 N-acetyltransferase 2 multiple interactions ISO [xanthohumol co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of NAT2 mRNA CTD PMID:22138251 NCBI chr16:23,960,709...23,991,570
Ensembl chr16:23,961,067...23,991,570
JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA] CTD PMID:23994090 NCBI chr18:77,203,517...77,322,690
Ensembl chr18:77,203,525...77,322,690
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects localization
multiple interactions
increases expression
increases activity
ISO xanthohumol affects the localization of NFE2L2 protein
[xanthohumol co-treated with phenethyl isothiocyanate] results in increased activity of NFE2L2 protein; [xanthohumol co-treated with phenethyl isothiocyanate] results in increased expression of and results in increased activity of NFE2L2 protein; [xanthohumol co-treated with phenethyl isothiocyanate] results in increased expression of NFE2L2 mRNA; [xanthohumol co-treated with Resveratrol] results in increased expression of NFE2L2 mRNA; [xanthohumol co-treated with Resveratrol] results in increased expression of NFE2L2 protein
xanthohumol results in increased expression of NFE2L2 mRNA; xanthohumol results in increased expression of NFE2L2 protein
xanthohumol results in increased activity of NFE2L2 protein
CTD PMID:23085367 PMID:32070777 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
decreases activity
decreases expression
ISO [xanthohumol co-treated with phenethyl isothiocyanate] results in decreased expression of and results in decreased activity of NFKB1 protein; [xanthohumol co-treated with phenethyl isothiocyanate] results in decreased expression of NFKB1 mRNA; [xanthohumol co-treated with Resveratrol] results in decreased expression of NFKB1 mRNA
xanthohumol results in decreased activity of NFKB1 protein
xanthohumol results in decreased expression of NFKB1 mRNA
CTD PMID:32070777 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP xanthohumol inhibits the reaction [Azoxymethane results in increased expression of NOS2 mRNA] CTD PMID:31714664 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
ISO xanthohumol results in increased expression of NQO1 protein
[indole-3-carbinol co-treated with xanthohumol] results in increased expression of NQO1 mRNA; [phenethyl isothiocyanate co-treated with xanthohumol] results in increased expression of NQO1 mRNA; [Resveratrol co-treated with xanthohumol] results in increased expression of NQO1 mRNA; [xanthohumol co-treated with phenethyl isothiocyanate] results in increased expression of NQO1 protein
xanthohumol results in increased expression of NQO1 mRNA; xanthohumol results in increased expression of NQO1 protein
CTD PMID:23085367 PMID:26473469 PMID:32070777 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Ostm1 osteoclastogenesis associated transmembrane protein 1 multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of OSTM1 mRNA] CTD PMID:23994090 NCBI chr20:47,394,979...47,430,304
Ensembl chr20:47,395,014...47,430,284
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO xanthohumol results in increased cleavage of PARP1 protein CTD PMID:15995977 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of PIK3CG mRNA] CTD PMID:23994090 NCBI chr 6:51,465,696...51,501,234
Ensembl chr 6:51,465,908...51,498,337
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases activity
multiple interactions
decreases expression
ISO
EXP
xanthohumol results in decreased activity of PTGS2 protein
[xanthohumol co-treated with indole-3-carbinol] results in decreased expression of PTGS2 mRNA; [xanthohumol co-treated with phenethyl isothiocyanate] results in decreased expression of PTGS2 mRNA; [xanthohumol co-treated with phenethyl isothiocyanate] results in decreased expression of PTGS2 protein; [xanthohumol co-treated with Resveratrol] results in decreased expression of PTGS2 mRNA
xanthohumol results in decreased expression of PTGS2 mRNA
xanthohumol inhibits the reaction [Azoxymethane results in increased expression of PTGS2 mRNA]
CTD PMID:17590382 PMID:31714664 PMID:32070777 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Pxn paxillin decreases expression ISO xanthohumol results in decreased expression of PXN protein CTD PMID:23503627 NCBI chr12:46,797,953...46,845,107
Ensembl chr12:46,797,954...46,845,080
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases activity
decreases expression
ISO [indole-3-carbinol co-treated with xanthohumol] results in decreased activity of RELA protein; [indole-3-carbinol co-treated with xanthohumol] results in decreased expression of RELA mRNA; [phenethyl isothiocyanate co-treated with xanthohumol] results in decreased expression of and results in decreased activity of RELA protein; [phenethyl isothiocyanate co-treated with xanthohumol] results in decreased expression of RELA mRNA; [Resveratrol co-treated with xanthohumol] results in decreased activity of RELA protein; [Resveratrol co-treated with xanthohumol] results in decreased expression of RELA mRNA
xanthohumol results in decreased activity of RELA protein
xanthohumol results in decreased expression of RELA mRNA
CTD PMID:32070777 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G S100a4 S100 calcium-binding protein A4 decreases expression ISO xanthohumol results in decreased expression of S100A4 protein CTD PMID:23503627 NCBI chr 2:189,997,278...189,999,587
Ensembl chr 2:189,997,129...189,999,604
JBrowse link
G Sele selectin E multiple interactions ISO xanthohumol inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:23503627 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of SRC mRNA] CTD PMID:23994090 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases expression
decreases expression
ISO xanthohumol results in increased expression of SULT1A1 mRNA
xanthohumol results in decreased expression of SULT1A1 mRNA
CTD PMID:22138251 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Tcirg1 T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of TCIRG1 mRNA] CTD PMID:23994090 NCBI chr 1:219,126,687...219,139,466
Ensembl chr 1:219,127,602...219,139,464
JBrowse link
G Tff1 trefoil factor 1 increases expression ISO xanthohumol results in increased expression of TFF1 mRNA CTD PMID:16019205 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO xanthohumol inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:23503627 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions
decreases response to substance
ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of AKT2 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of CAR2 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of CLCN7 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of GAB2 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of MAPK3 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of OSTM1 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of PIK3CG mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of SRC mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of TCIRG1 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of TRAF6 mRNA]
xanthohumol results in decreased susceptibility to TNFSF11 protein
CTD PMID:23994090 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
G Tp53 tumor protein p53 increases expression ISO xanthohumol results in increased expression of TP53; xanthohumol results in increased expression of TP53 mRNA; xanthohumol results in increased expression of TP53 protein CTD PMID:23085367 PMID:26297991 PMID:27317025 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of TRAF6 mRNA] CTD PMID:23994090 NCBI chr 3:91,252,829...91,271,607
Ensembl chr 3:91,252,829...91,271,607
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions
increases expression
ISO xanthohumol promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of UGT1A1 mRNA]
xanthohumol results in increased expression of UGT1A1 mRNA
CTD PMID:22138251 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 multiple interactions ISO [xanthohumol co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of UGT1A2 mRNA CTD PMID:22138251 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
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G Vwf von Willebrand factor increases expression ISO xanthohumol results in increased expression of VWF mRNA CTD PMID:16019205 NCBI chr 4:158,085,059...158,219,525
Ensembl chr 4:158,088,505...158,219,523
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  CHEBI ontology 19786
    role 19732
      biological role 19732
        biochemical role 19333
          enzyme inhibitor 18267
            EC 2.* (transferase) inhibitor 13900
              EC 2.3.* (acyltransferase) inhibitor 575
                EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor 415
                  EC 2.3.1.20 (diacylglycerol O-acyltransferase) inhibitor 63
                    xanthohumol 63
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