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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:antiplasmodial drug
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Accession:CHEBI:64915 term browser browse the term
Definition:An antiparasitic drug which is effective against Apicomplexan parasites in the genus Plasmodium. The genus contains over 200 species and includes those responsible for malaria.
Synonyms:related_synonym: antiplasmodial agent;   antiplasmodial agents;   antiplasmodial drugs;   antiplasmodium agent;   antiplasmodium agents;   antiplasmodium drug;   antiplasmodium drugs


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(+)-artemisinin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1I3 nuclear receptor subfamily 1 group I member 3 increases activity
multiple interactions		 EXP artemisinin results in increased activity of NR1I3 protein; artemisinin results in increased activity of NR1I3 protein alternative form; artemisinin results in increased activity of NR1I3 protein mutant form
androstan-3-ol inhibits the reaction [artemisinin results in increased activity of NR1I3 protein mutant form]; artemisinin inhibits the reaction [androstan-3-ol results in decreased activity of NR1I3 protein alternative form]; artemisinin inhibits the reaction [Imidazoles results in decreased activity of NR1I3 protein alternative form]; Imidazoles inhibits the reaction [artemisinin results in increased activity of NR1I3 protein mutant form]		 CTD PMID:21778469 PMID:27732639 NCBI chr38:21,252,874...21,257,951
Ensembl chr38:21,253,089...21,258,827 		JBrowse link
quinacrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HEXB hexosaminidase subunit beta multiple interactions EXP Quinacrine promotes the reaction [mastoparan results in increased secretion of HEXB protein] CTD PMID:21671308 NCBI chr 2:57,221,809...57,248,432
Ensembl chr 2:57,222,186...57,248,417 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 499
    role 499
      biological role 499
        antimicrobial agent 125
          antimicrobial drug 34
            antiprotozoal drug 18
              antiplasmodial drug 2
                (-)-annonaine + 0
                (-)-vincadifformine 0
                (1S,3S,4R,7S,8S,11S,12S,13S,15R,20R)-7-formamido-20-isocyanoisocycloamphilectane 0
                (R)-4''-methoxydalbergione 0
                1,2-dehydrogeissoschizoline 0
                19-(2-furyl)nonadeca-5,7-diynoic acid 0
                1R,4S,6R-1,4-endoperoxy-bisabola-2,10-diene 0
                1S,4R,6R-1,4-endoperoxy-bisabola-2,10-diene 0
                2',6'-dihydroxy-4'-methoxydihydrochalcone 0
                2-O-E-p-coumaroyl alphitolic acid 0
                4'-O-demethylknipholone-4'-O-beta-D-glucopyranoside 0
                5-galloylquercetin-3-O-alpha-L-arabinofuranoside 0
                7,4'-dihydroxy-3'-methoxyisoflavone 0
                9-methoxycanthin-6-one 0
                Eunicea sesquiterpenoid 7 0
                SID 26681509 0
                alisiaquinol 0
                alisiaquinone A + 0
                alisiaquinone B 0
                alisiaquninone C 0
                allanxanthone C 0
                ancistrotanzanine A 0
                ancistrotanzanine B 0
                antimalarial + 2
                arterolane 0
                arterolane maleate 0
                asperentin + 0
                azadirone + 0
                beta-thujaplicin 0
                dehydrodiconiferyl dibenzoate 0
                dioncophylline C 0
                erybraedin A 0
                gaboroquinone A 0
                geissoschizoline 0
                glabridin 0
                hookerianamide H 0
                hookerianamide I 0
                klugine 0
                knipholone + 0
                mustakone 0
                obtusafuran 0
                rutarin 0
                scleropyric acid 0
                spectinabilin 0
                strychnogucine A 0
                strychnogucine B 0
                syncarpamide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 499
    role 499
      application 457
        pharmaceutical 451
          drug 451
            antiinfective agent 80
              antiparasitic agent 21
                antiprotozoal drug 18
                  antiplasmodial drug 2
                    (-)-annonaine + 0
                    (-)-vincadifformine 0
                    (1S,3S,4R,7S,8S,11S,12S,13S,15R,20R)-7-formamido-20-isocyanoisocycloamphilectane 0
                    (R)-4''-methoxydalbergione 0
                    1,2-dehydrogeissoschizoline 0
                    19-(2-furyl)nonadeca-5,7-diynoic acid 0
                    1R,4S,6R-1,4-endoperoxy-bisabola-2,10-diene 0
                    1S,4R,6R-1,4-endoperoxy-bisabola-2,10-diene 0
                    2',6'-dihydroxy-4'-methoxydihydrochalcone 0
                    2-O-E-p-coumaroyl alphitolic acid 0
                    4'-O-demethylknipholone-4'-O-beta-D-glucopyranoside 0
                    5-galloylquercetin-3-O-alpha-L-arabinofuranoside 0
                    7,4'-dihydroxy-3'-methoxyisoflavone 0
                    9-methoxycanthin-6-one 0
                    Eunicea sesquiterpenoid 7 0
                    SID 26681509 0
                    alisiaquinol 0
                    alisiaquinone A + 0
                    alisiaquinone B 0
                    alisiaquninone C 0
                    allanxanthone C 0
                    ancistrotanzanine A 0
                    ancistrotanzanine B 0
                    antimalarial + 2
                    arterolane 0
                    arterolane maleate 0
                    asperentin + 0
                    azadirone + 0
                    beta-thujaplicin 0
                    dehydrodiconiferyl dibenzoate 0
                    dioncophylline C 0
                    erybraedin A 0
                    gaboroquinone A 0
                    geissoschizoline 0
                    glabridin 0
                    hookerianamide H 0
                    hookerianamide I 0
                    klugine 0
                    knipholone + 0
                    mustakone 0
                    obtusafuran 0
                    rutarin 0
                    scleropyric acid 0
                    spectinabilin 0
                    strychnogucine A 0
                    strychnogucine B 0
                    syncarpamide 0
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