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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:antimycobacterial drug
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Accession:CHEBI:64912 term browser browse the term
Definition:A drug used to treat or prevent infections caused by Mycobacteria, a genus of actinobacteria. Aerobic and nonmotile, members of the genus include the pathogens responsible for causing tuberculosis and leprosy.
Synonyms:related_synonym: antimycobacterial agent;   antimycobacterial agents;   antimycobacterial drugs;   antimycobacterials;   antimycobacterium



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3-nitropropanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
increases activity
EXP thymoquinone inhibits the reaction [3-nitropropionic acid results in increased activity of ACHE protein]; trandolapril inhibits the reaction [3-nitropropionic acid results in increased activity of ACHE protein] CTD PMID:25445565 PMID:27206696 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
EXP 3-nitropropionic acid results in decreased phosphorylation of AKT1 protein
topiramate inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of AKT1 protein]
CTD PMID:29753867 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions
increases expression
EXP naringin inhibits the reaction [3-nitropropionic acid results in increased expression of BAD mRNA] CTD PMID:21945202 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects localization
increases expression
multiple interactions
EXP 3-nitropropionic acid affects the localization of BAX protein
3-nitropropionic acid results in increased expression of BAX mRNA
[Tacrolimus co-treated with 3-nitropropionic acid] affects the localization of BAX protein; Ginkgo biloba extract inhibits the reaction [3-nitropropionic acid results in increased expression of BAX mRNA]; naringin inhibits the reaction [3-nitropropionic acid results in increased expression of BAX mRNA]; ursodoxicoltaurine inhibits the reaction [3-nitropropionic acid affects the localization of BAX protein]
CTD PMID:11080188 PMID:15571979 PMID:21827809 PMID:21945202 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
EXP [Tacrolimus co-treated with 3-nitropropionic acid] affects the localization of BCL2 protein; BCL2 protein promotes the reaction [BDNF protein results in decreased susceptibility to 3-nitropropionic acid]; naringin inhibits the reaction [3-nitropropionic acid results in decreased expression of BCL2 mRNA] CTD PMID:15571979 PMID:19428112 PMID:21945202 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression
multiple interactions
EXP 3-nitropropionic acid results in decreased expression of BCL2L1 mRNA
Ginkgo biloba extract inhibits the reaction [3-nitropropionic acid results in decreased expression of BCL2L1 mRNA]
CTD PMID:21827809 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bdnf brain-derived neurotrophic factor decreases response to substance
decreases expression
multiple interactions
EXP BDNF protein results in decreased susceptibility to 3-nitropropionic acid
3-nitropropionic acid results in decreased expression of BDNF protein
BCL2 protein promotes the reaction [BDNF protein results in decreased susceptibility to 3-nitropropionic acid]; Dinitrochlorobenzene inhibits the reaction [BDNF protein results in decreased susceptibility to 3-nitropropionic acid]; KT 5823 inhibits the reaction [BDNF protein results in decreased susceptibility to 3-nitropropionic acid]; topiramate inhibits the reaction [3-nitropropionic acid results in decreased expression of BDNF protein]
CTD PMID:19428112 PMID:29753867 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Casp2 caspase 2 increases activity EXP 3-nitropropionic acid results in increased activity of CASP2 protein CTD PMID:15571979 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage
multiple interactions
EXP 3-nitropropionic acid results in increased activity of CASP3 protein
3-nitropropionic acid results in increased cleavage of CASP3 protein
naringin inhibits the reaction [3-nitropropionic acid results in increased cleavage of CASP3 protein]; Tacrolimus inhibits the reaction [3-nitropropionic acid results in increased activity of CASP3 protein]; topiramate inhibits the reaction [3-nitropropionic acid results in increased activity of CASP3 protein]
CTD PMID:15571979 PMID:21945202 PMID:29753867 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases activity EXP 3-nitropropionic acid results in increased activity of CASP8 protein CTD PMID:15571979 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity EXP 3-nitropropionic acid results in increased activity of CASP9 protein CTD PMID:15571979 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions
decreases activity
decreases expression
EXP 3-nitropropionic acid affects the reaction [[lead acetate results in increased abundance of Lead] affects the reaction [Ethanol affects the expression of CAT protein]]; 3-nitropropionic acid affects the reaction [[lead acetate results in increased abundance of Lead] which affects the expression of CAT protein]; 3-nitropropionic acid affects the reaction [Ethanol affects the expression of CAT protein]; Cyclosporine inhibits the reaction [3-nitropropionic acid results in decreased expression of CAT protein]; naringin inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]; Nitric Oxide promotes the reaction [Sertraline inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]]; Nitric Oxide promotes the reaction [Venlafaxine Hydrochloride inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]]; Sertraline inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]; thymoquinone analog inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]; thymoquinone inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]; trandolapril inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]; Venlafaxine Hydrochloride inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein] CTD PMID:20305041 PMID:20448265 PMID:21945202 PMID:25445565 PMID:27206696 More... NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccnd1 cyclin D1 increases expression EXP 3-nitropropionic acid results in increased expression of CCND1 protein CTD PMID:21827787 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdk4 cyclin-dependent kinase 4 increases expression EXP 3-nitropropionic acid results in increased expression of CDK4 protein CTD PMID:21827787 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cnr1 cannabinoid receptor 1 affects expression EXP 3-nitropropionic acid affects the expression of CNR1 mRNA CTD PMID:15640759 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4i1 decreases expression ISO 3-nitropropionic acid results in decreased expression of COX4I1 mRNA CTD PMID:19306371 NCBI chr19:48,721,680...48,727,920
Ensembl chr19:48,721,199...48,727,921
JBrowse link
G Cox4i2 cytochrome c oxidase subunit 4i2 increases response to substance
increases expression
ISO COX4I2 mRNA results in increased susceptibility to 3-nitropropionic acid
3-nitropropionic acid results in increased expression of COX4I2 mRNA
CTD PMID:19306371 NCBI chr 3:141,228,443...141,239,337
Ensembl chr 3:141,228,443...141,239,331
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
decreases phosphorylation
EXP topiramate inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of CREB1 protein] CTD PMID:29753867 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Eno2 enolase 2 decreases expression
multiple interactions
EXP 3-nitropropionic acid results in decreased expression of ENO2 mRNA
Cannabidiol inhibits the reaction [3-nitropropionic acid results in decreased expression of ENO2 mRNA]
CTD PMID:17672854 NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions
increases expression
EXP Ginkgo biloba extract inhibits the reaction [3-nitropropionic acid results in increased expression of GAPDH mRNA] CTD PMID:21827809 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions EXP [naringin co-treated with 3-nitropropionic acid] results in increased expression of GCLC mRNA CTD PMID:22871521 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 decreases expression
multiple interactions
EXP 3-nitropropionic acid results in decreased expression of GRIA2 mRNA
topiramate inhibits the reaction [3-nitropropionic acid results in decreased expression of GRIA2 mRNA]
CTD PMID:29753867 NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases phosphorylation
multiple interactions
EXP 3-nitropropionic acid results in decreased phosphorylation of GSK3B protein
topiramate inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of GSK3B protein]
CTD PMID:29753867 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
decreases activity
EXP naringin inhibits the reaction [3-nitropropionic acid results in decreased activity of GSR protein]; thymoquinone analog inhibits the reaction [3-nitropropionic acid results in decreased activity of GSR protein]; thymoquinone inhibits the reaction [3-nitropropionic acid results in decreased activity of GSR protein] CTD PMID:21945202 PMID:27206696 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions EXP [naringin co-treated with 3-nitropropionic acid] results in increased expression of GSTP1 mRNA CTD PMID:22871521 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP [naringin co-treated with 3-nitropropionic acid] results in increased expression of HMOX1 mRNA CTD PMID:22871521 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
ISO 3-nitropropionic acid results in increased expression of IL6 mRNA
delta(9)-tetrahydrocannabinolic acid inhibits the reaction [3-nitropropionic acid results in increased expression of IL6 mRNA]
CTD PMID:28853159 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mapt microtubule-associated protein tau affects localization EXP 3-nitropropionic acid affects the localization of MAPT protein CTD PMID:17634376 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression EXP 3-nitropropionic acid results in decreased expression of MKI67 protein CTD PMID:21827787 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP [naringin co-treated with 3-nitropropionic acid] affects the localization of NFE2L2 protein CTD PMID:22871521 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases response to substance ISO NFKB1 results in decreased susceptibility to 3-nitropropionic acid CTD PMID:11211235 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
EXP
ISO
3-nitropropionic acid results in increased expression of NOS2 mRNA
delta(9)-tetrahydrocannabinolic acid inhibits the reaction [3-nitropropionic acid results in increased expression of NOS2 mRNA]; T 0070907 inhibits the reaction [delta(9)-tetrahydrocannabinolic acid inhibits the reaction [3-nitropropionic acid results in increased expression of NOS2 mRNA]]
naringin inhibits the reaction [3-nitropropionic acid results in increased expression of NOS2 mRNA]
CTD PMID:22871521 PMID:28853159 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP [naringin co-treated with 3-nitropropionic acid] results in increased expression of NQO1 mRNA CTD PMID:22871521 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Penk proenkephalin decreases expression
multiple interactions
EXP 3-nitropropionic acid results in decreased expression of PENK mRNA
Cannabidiol inhibits the reaction [3-nitropropionic acid results in decreased expression of PENK mRNA]
CTD PMID:17672854 NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129
JBrowse link
G Pick1 protein interacting with PRKCA 1 increases expression
multiple interactions
EXP 3-nitropropionic acid results in increased expression of PICK1 protein
topiramate inhibits the reaction [3-nitropropionic acid results in increased expression of PICK1 protein]
CTD PMID:29753867 NCBI chr 7:110,796,623...110,816,850
Ensembl chr 7:110,797,117...110,816,848
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
EXP 3-nitropropionic acid results in increased expression of PTGS2 mRNA
naringin inhibits the reaction [3-nitropropionic acid results in increased expression of PTGS2 mRNA]
CTD PMID:22871521 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression EXP 3-nitropropionic acid results in decreased expression of RB1 protein CTD PMID:21827787 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Sirt1 sirtuin 1 decreases expression ISO
EXP
3-nitropropionic acid results in decreased expression of SIRT1 protein CTD PMID:18538940 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
decreases expression
EXP Cannabidiol inhibits the reaction [3-nitropropionic acid results in decreased expression of SOD1 mRNA] CTD PMID:17672854 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 decreases expression
multiple interactions
EXP 3-nitropropionic acid results in decreased expression of SOD2 mRNA
Cannabidiol inhibits the reaction [3-nitropropionic acid results in decreased expression of SOD2 mRNA]
CTD PMID:17672854 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Tac1 tachykinin, precursor 1 decreases expression
multiple interactions
EXP 3-nitropropionic acid results in decreased expression of TAC1 mRNA
Cannabidiol inhibits the reaction [3-nitropropionic acid results in decreased expression of TAC1 mRNA]
CTD PMID:17672854 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
EXP
ISO
3-nitropropionic acid results in increased expression of TNF mRNA
delta(9)-tetrahydrocannabinolic acid inhibits the reaction [3-nitropropionic acid results in increased expression of TNF mRNA]; T 0070907 inhibits the reaction [delta(9)-tetrahydrocannabinolic acid inhibits the reaction [3-nitropropionic acid results in increased expression of TNF mRNA]]
naringin inhibits the reaction [3-nitropropionic acid results in increased expression of TNF mRNA]
CTD PMID:22871521 PMID:28853159 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
4-aminosalicylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp6 bone morphogenetic protein 6 increases expression ISO Aminosalicylic Acid results in increased expression of BMP6 mRNA CTD PMID:32816093 NCBI chr17:26,318,121...26,469,034
Ensembl chr17:26,318,569...26,470,365
JBrowse link
G Ereg epiregulin increases expression ISO Aminosalicylic Acid results in increased expression of EREG mRNA CTD PMID:32816093 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062
JBrowse link
G Il24 interleukin 24 increases expression ISO Aminosalicylic Acid results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases expression ISO Aminosalicylic Acid results in increased expression of MET mRNA CTD PMID:32816093 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
JBrowse link
G Nat1 N-acetyltransferase 1 increases acetylation ISO NAT1 protein results in increased acetylation of Aminosalicylic Acid CTD PMID:15627487 PMID:16003948 NCBI chr16:22,218,217...22,238,516 JBrowse link
G Nat2 N-acetyltransferase 2 multiple interactions ISO [Peroxynitrous Acid results in decreased activity of NAT2 protein] which results in decreased acetylation of Aminosalicylic Acid CTD PMID:19248797 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 increases expression ISO Aminosalicylic Acid results in increased expression of PID1 mRNA CTD PMID:32816093 NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Aminosalicylic Acid results in increased expression of SLC7A11 mRNA CTD PMID:32816093 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Aminosalicylic Acid results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
JBrowse link
9-hydroxycanthin-6-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases cleavage ISO 9-hydroxycanthin-6-one results in increased cleavage of CASP3 protein CTD PMID:29225138 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases cleavage ISO 9-hydroxycanthin-6-one results in increased cleavage of CASP8 protein CTD PMID:29225138 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases cleavage ISO 9-hydroxycanthin-6-one results in increased cleavage of CASP9 protein CTD PMID:29225138 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO 9-hydroxycanthin-6-one results in decreased expression of CCL2 mRNA CTD PMID:29225138 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO 9-hydroxycanthin-6-one results in decreased expression of CCL5 mRNA CTD PMID:29225138 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
azadiradione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO azadiradione results in increased activity of CASP3 protein CTD PMID:21381696 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases activity ISO azadiradione results in increased activity of CASP8 protein CTD PMID:21381696 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity ISO azadiradione results in increased activity of CASP9 protein CTD PMID:21381696 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO azadiradione results in increased expression of HSPA1A mRNA CTD PMID:30309986
clofazimine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Clofazimine results in decreased activity of ABCB11 protein CTD PMID:20829430 PMID:23956101 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases expression EXP Clofazimine results in increased expression of ACACA mRNA CTD PMID:31393584 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha increases expression EXP Clofazimine results in increased expression of CEBPA protein CTD PMID:31393584 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 decreases expression EXP Clofazimine results in decreased expression of DGAT1 mRNA CTD PMID:31393584 NCBI chr 7:108,223,860...108,235,413
Ensembl chr 7:108,218,524...108,234,299
JBrowse link
G Fas Fas cell surface death receptor increases expression EXP Clofazimine results in increased expression of FAS mRNA CTD PMID:31393584 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Clofazimine inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Clofazimine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression EXP Clofazimine results in increased expression of PPARG mRNA; Clofazimine results in increased expression of PPARG protein CTD PMID:31393584 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression EXP Clofazimine results in increased expression of SREBF1 mRNA CTD PMID:31393584 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Zfp423 zinc finger protein 423 increases expression EXP Clofazimine results in increased expression of ZFP423 mRNA CTD PMID:31393584 NCBI chr19:19,111,538...19,407,371
Ensembl chr19:19,110,238...19,407,373
JBrowse link
D-cycloserine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO Cycloserine inhibits the reaction [resveratrol results in increased expression of DDIT3 protein] CTD PMID:24264887 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Egr1 early growth response 1 increases expression EXP Cycloserine results in increased expression of EGR1 protein CTD PMID:19144966 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Cycloserine promotes the reaction [Clozapine results in increased expression of FOS mRNA] CTD PMID:12464447 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Homer1 homer scaffold protein 1 multiple interactions EXP Cycloserine inhibits the reaction [Clozapine results in increased expression of HOMER1 mRNA]; Cycloserine inhibits the reaction [Haloperidol results in increased expression of HOMER1 mRNA] CTD PMID:12464447 NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP Cycloserine inhibits the reaction [Dronabinol results in increased activity of MAPK1 protein] CTD PMID:11903061 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP Cycloserine inhibits the reaction [Dronabinol results in increased activity of MAPK3 protein] CTD PMID:11903061 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Cycloserine inhibits the reaction [resveratrol results in increased cleavage of PARP1 protein] CTD PMID:24264887 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
dapsone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 decreases expression EXP Dapsone metabolite results in decreased expression of ABCC2 protein CTD PMID:15863252 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Cat catalase decreases activity EXP Dapsone results in decreased activity of CAT protein CTD PMID:18602405 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO Dapsone inhibits the reaction [Paraquat results in increased expression of CCL3 mRNA] CTD PMID:21765237 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 multiple interactions ISO Dapsone analog inhibits the reaction [Metribolone results in increased expression of CXCR4 mRNA] CTD PMID:21440447 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity ISO Dapsone results in increased activity of CYP1A1 protein CTD PMID:12451431 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO CYP2B6 protein results in increased metabolism of and results in increased susceptibility to Dapsone CTD PMID:19998329 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions ISO CYP2C19 protein results in increased metabolism of and results in increased susceptibility to Dapsone CTD PMID:19998329 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases metabolic processing ISO CYP2C8 protein results in increased metabolism of Dapsone CTD PMID:17286541
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO CYP2D6 protein results in increased metabolism of and results in increased susceptibility to Dapsone CTD PMID:19998329 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
affects metabolic processing
EXP
ISO
[SOD2 co-treated with CYP3A4] affects the susceptibility to Dapsone
CYP3A4 protein affects the metabolism of Dapsone
CYP3A4 protein results in increased metabolism of and results in increased susceptibility to Dapsone
CTD PMID:12920490 PMID:15327588 PMID:19501153 PMID:19998329 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO Dapsone inhibits the reaction [Paraquat results in increased expression of EDN1 mRNA] CTD PMID:21765237 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Elk4 ETS transcription factor ELK4 multiple interactions ISO Dapsone analog inhibits the reaction [Metribolone results in increased expression of ELK4 mRNA] CTD PMID:21440447 NCBI chr13:43,451,130...43,475,035
Ensembl chr13:43,435,843...43,475,035
JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 multiple interactions ISO Dapsone analog inhibits the reaction [Metribolone results in increased expression of FKBP5 mRNA] CTD PMID:21440447 NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases response to substance ISO G6PD protein mutant form results in increased susceptibility to Dapsone CTD PMID:7752092 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 multiple interactions ISO Dapsone analog inhibits the reaction [Metribolone results in increased expression of GREB1 mRNA] CTD PMID:21440447 NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO Dapsone inhibits the reaction [Paraquat results in decreased expression of GSR protein]; Dapsone inhibits the reaction [Paraquat results in increased expression of GSR mRNA] CTD PMID:21765237 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Dapsone inhibits the reaction [Paraquat results in decreased expression of GSTP1 protein] CTD PMID:21765237 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Ifng interferon gamma multiple interactions ISO [Dapsone co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA CTD PMID:29594315 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions ISO Dapsone analog inhibits the reaction [Metribolone results in increased expression of IGF1R mRNA] CTD PMID:21440447 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Il1b interleukin 1 beta decreases expression ISO Dapsone results in decreased expression of IL1B mRNA CTD PMID:29594315 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Dapsone co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA CTD PMID:29594315 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Maf MAF bZIP transcription factor multiple interactions ISO Dapsone analog inhibits the reaction [Metribolone results in increased expression of MAF mRNA] CTD PMID:21440447 NCBI chr19:43,353,867...43,713,162
Ensembl chr19:43,360,342...43,712,365
JBrowse link
G Mak male germ cell-associated kinase multiple interactions ISO Dapsone analog inhibits the reaction [Metribolone results in increased expression of MAK mRNA] CTD PMID:21440447 NCBI chr17:23,683,674...23,731,125
Ensembl chr17:23,693,878...23,730,001
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Dapsone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein] CTD PMID:21436242 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Dapsone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein] CTD PMID:21436242 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Dapsone inhibits the reaction [Paraquat results in increased expression of MMP9 protein] CTD PMID:21765237 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Nat2 N-acetyltransferase 2 increases acetylation ISO NAT2 protein results in increased acetylation of Dapsone CTD PMID:14528063 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
JBrowse link
G Nkx3-1 NK3 homeobox 1 multiple interactions ISO Dapsone analog inhibits the reaction [Metribolone results in increased expression of NKX3-1 mRNA] CTD PMID:21440447 NCBI chr15:44,473,851...44,476,443
Ensembl chr15:44,473,851...44,476,441
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO Dapsone inhibits the reaction [Paraquat results in increased expression of NOX4 mRNA] CTD PMID:20164675 PMID:21765237 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions ISO Dapsone analog inhibits the reaction [Metribolone results in increased expression of NR4A1 mRNA] CTD PMID:21440447 NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
JBrowse link
G Per1 period circadian regulator 1 multiple interactions ISO Dapsone analog inhibits the reaction [Metribolone results in increased expression of PER1 mRNA] CTD PMID:21440447 NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431
JBrowse link
G Plcb2 phospholipase C, beta 2 multiple interactions ISO Dapsone inhibits the reaction [Paraquat results in increased phosphorylation of PLCB2 protein] CTD PMID:20164675 NCBI chr 3:105,683,676...105,704,384
Ensembl chr 3:105,684,815...105,704,302
JBrowse link
G Prkd1 protein kinase D1 multiple interactions ISO Dapsone inhibits the reaction [Paraquat results in increased phosphorylation of PRKD1 protein] CTD PMID:21765237 NCBI chr 6:67,725,193...68,039,002
Ensembl chr 6:67,725,905...68,039,042
JBrowse link
G Prmt1 protein arginine methyltransferase 1 decreases activity ISO Dapsone analog results in decreased activity of PRMT1 protein; Dapsone results in decreased activity of PRMT1 protein CTD PMID:21440447 NCBI chr 1:95,458,853...95,468,176
Ensembl chr 1:95,458,850...95,468,345
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Dapsone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of RELA protein] CTD PMID:21436242 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Slc4a2 solute carrier family 4 member 2 decreases expression EXP Dapsone metabolite results in decreased expression of SLC4A2 protein CTD PMID:15863252 NCBI chr 4:10,736,419...10,754,407
Ensembl chr 4:10,736,425...10,752,965
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP
ISO
[SOD2 co-treated with CYP3A4] affects the susceptibility to Dapsone
Dapsone inhibits the reaction [Paraquat results in decreased expression of SOD2 protein]
CTD PMID:19501153 PMID:21765237 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Dapsone inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA] CTD PMID:21765237 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tmprss2 transmembrane serine protease 2 multiple interactions ISO Dapsone analog inhibits the reaction [Metribolone results in increased expression of TMPRSS2 mRNA] CTD PMID:21440447 NCBI chr11:36,934,306...36,973,779
Ensembl chr11:36,934,306...36,973,715
JBrowse link
dehydrocostus lactone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmox1 heme oxygenase 1 increases expression ISO dehydrocostus lactone results in increased expression of HMOX1 protein CTD PMID:23942037 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il6 interleukin 6 multiple interactions ISO dehydrocostus lactone inhibits the reaction [Hydrogen Peroxide results in increased secretion of IL6 protein] CTD PMID:19457452 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO dehydrocostus lactone inhibits the reaction [Ethanol results in increased expression of NOS2 protein] CTD PMID:26970604 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO dehydrocostus lactone inhibits the reaction [Ethanol results in increased expression of PTGS2 protein] CTD PMID:26970604 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO dehydrocostus lactone inhibits the reaction [Ethanol results in increased expression of TNF protein] CTD PMID:26970604 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO dehydrocostus lactone inhibits the reaction [Hydrogen Peroxide results in increased secretion of TNFSF11 protein] CTD PMID:19457452 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
JBrowse link
ergosterol peroxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO ergosterol-5,8-peroxide results in increased activity of CASP3 protein CTD PMID:20100469 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
ethambutol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin I converting enzyme 2 increases expression ISO Ethambutol results in increased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Bmp6 bone morphogenetic protein 6 decreases expression ISO Ethambutol results in decreased expression of BMP6 mRNA CTD PMID:32816093 NCBI chr17:26,318,121...26,469,034
Ensembl chr17:26,318,569...26,470,365
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 affects expression EXP Ethambutol affects the expression of CCL2 mRNA CTD PMID:25051504 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 affects expression EXP Ethambutol affects the expression of CCL5 protein CTD PMID:25051504 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ctsd cathepsin D multiple interactions EXP Ethambutol results in increased expression of and affects the localization of CTSD protein; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Ethambutol results in increased expression of and affects the localization of CTSD protein] CTD PMID:19063910 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO Ethambutol results in decreased activity of CYP1A2 protein CTD PMID:24910189 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO Ethambutol results in decreased activity of CYP2C19 protein CTD PMID:24910189 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO Ethambutol results in decreased activity of CYP2D6 protein CTD PMID:24910189 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity
multiple interactions
ISO
EXP
Ethambutol results in decreased activity of CYP2E1 protein
[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein; [Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA; [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]; [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA]; Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]; Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA]
CTD PMID:24910189 PMID:27919644 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions EXP [Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA; [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA]; Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA] CTD PMID:27919644 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Gzmb granzyme B increases secretion ISO Ethambutol results in increased secretion of GZMB protein CTD PMID:27933861 NCBI chr15:30,343,361...30,346,792 JBrowse link
G Ifng interferon gamma increases secretion ISO Ethambutol results in increased secretion of IFNG protein CTD PMID:27933861 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 decreases expression EXP Ethambutol results in decreased expression of IL10 protein CTD PMID:25051504 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il13 interleukin 13 increases secretion ISO Ethambutol results in increased secretion of IL13 protein CTD PMID:27933861 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Ethambutol results in increased expression of IL1A mRNA CTD PMID:32816093 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta decreases expression EXP Ethambutol results in decreased expression of IL1B mRNA CTD PMID:25051504 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 decreases expression EXP Ethambutol results in decreased expression of IL6 protein CTD PMID:25051504 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 increases expression
multiple interactions
EXP Ethambutol results in increased expression of LAMP2 protein
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Ethambutol results in increased expression of LAMP2 protein]
CTD PMID:19063910 NCBI chr  X:117,173,097...117,222,090
Ensembl chr  X:117,057,606...117,260,522
JBrowse link
G Lep leptin decreases expression EXP Ethambutol results in decreased expression of LEP protein CTD PMID:25051504 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases expression ISO Ethambutol results in increased expression of MET mRNA CTD PMID:32816093 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 increases expression ISO Ethambutol results in increased expression of PID1 mRNA CTD PMID:32816093 NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Ethambutol results in increased expression of SLC7A11 mRNA CTD PMID:32816093 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Ethambutol results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
JBrowse link
G Tmprss2 transmembrane serine protease 2 increases expression ISO Ethambutol results in increased expression of TMPRSS2 mRNA CTD PMID:32808185 NCBI chr11:36,934,306...36,973,779
Ensembl chr11:36,934,306...36,973,715
JBrowse link
ethionamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin I converting enzyme 2 decreases expression ISO Ethionamide results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression EXP Ethionamide results in increased expression of CCL2 mRNA; Ethionamide results in increased expression of CCL2 protein CTD PMID:25051504 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 affects expression EXP Ethionamide affects the expression of CCL5 protein CTD PMID:25051504 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases expression EXP Ethionamide results in decreased expression of CXCL10 protein CTD PMID:25051504 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Fmo2 flavin containing dimethylaniline monoxygenase 2 increases oxidation ISO FMO2 protein results in increased oxidation of Ethionamide CTD PMID:26062974 NCBI chr13:75,221,149...75,244,377
Ensembl chr13:75,224,402...75,244,308
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO Ethionamide inhibits the reaction [arsenic trioxide results in increased expression of GCLM mRNA] CTD PMID:26708503 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Ethionamide inhibits the reaction [arsenic trioxide results in increased expression of HMOX1 mRNA] CTD PMID:26708503 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il10 interleukin 10 decreases expression EXP Ethionamide results in decreased expression of IL10 protein CTD PMID:25051504 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il12b interleukin 12B increases expression EXP Ethionamide results in increased expression of IL12B protein CTD PMID:25051504 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il1a interleukin 1 alpha increases expression EXP Ethionamide results in increased expression of IL1A protein CTD PMID:25051504 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta increases expression
affects expression
EXP Ethionamide results in increased expression of IL1B mRNA
Ethionamide affects the expression of IL1B protein
CTD PMID:25051504 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 decreases expression EXP Ethionamide results in decreased expression of IL6 protein CTD PMID:25051504 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO KEAP1 mRNA inhibits the reaction [Ethionamide results in increased susceptibility to arsenic trioxide] CTD PMID:26708503 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Lep leptin decreases expression EXP Ethionamide results in decreased expression of LEP protein CTD PMID:25051504 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO NFE2L2 mRNA promotes the reaction [Ethionamide results in increased susceptibility to arsenic trioxide] CTD PMID:26708503 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Srxn1 sulfiredoxin 1 multiple interactions ISO Ethionamide inhibits the reaction [arsenic trioxide results in increased expression of SRXN1 mRNA] CTD PMID:26708503 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
JBrowse link
G Tnf tumor necrosis factor increases expression EXP Ethionamide results in increased expression of TNF protein CTD PMID:25051504 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression EXP Ethionamide results in increased expression of VEGFA protein CTD PMID:25051504 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
isoniazide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin increases expression EXP Isoniazid results in increased expression of A2M mRNA CTD PMID:12883083 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases expression
EXP [Lipopolysaccharides co-treated with Isoniazid] results in decreased expression of ABCB11 mRNA; obeticholic acid inhibits the reaction [Isoniazid results in decreased expression of ABCB11 mRNA] CTD PMID:25331106 PMID:32673658 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression EXP Isoniazid results in increased expression of ABCC1 mRNA CTD PMID:11752103 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
decreases expression
EXP [Lipopolysaccharides co-treated with Isoniazid] results in decreased expression of ABCC2 mRNA
Isoniazid results in decreased expression of ABCC2 mRNA
CTD PMID:25331106 PMID:32673658 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions
decreases expression
EXP [Lipopolysaccharides co-treated with Isoniazid] results in increased expression of ABCC3 mRNA; obeticholic acid inhibits the reaction [Isoniazid results in decreased expression of ABCC3 mRNA] CTD PMID:25331106 PMID:32673658 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 decreases expression EXP Isoniazid results in decreased expression of ABCC4 mRNA CTD PMID:32673658 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 decreases expression EXP Isoniazid results in decreased expression of ABCC6 mRNA CTD PMID:16260000 NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464
JBrowse link
G Ace2 angiotensin I converting enzyme 2 decreases expression ISO Isoniazid results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Afp alpha-fetoprotein decreases expression ISO Isoniazid results in decreased expression of AFP mRNA CTD PMID:30008028 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
JBrowse link
G Agpat3 1-acylglycerol-3-phosphate O-acyltransferase 3 increases expression
multiple interactions
EXP Isoniazid results in increased expression of AGPAT3 mRNA
[Zidovudine co-treated with Isoniazid] results in increased expression of AGPAT3 mRNA; silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in increased expression of AGPAT3 mRNA]
CTD PMID:28619387 NCBI chr20:10,330,960...10,415,358
Ensembl chr20:10,384,507...10,415,358
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO Isoniazid results in increased expression of AKR1B10 mRNA CTD PMID:28444390 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
JBrowse link
G Alas1 5'-aminolevulinate synthase 1 increases expression ISO Isoniazid results in increased expression of ALAS1 protein CTD PMID:27438535 PMID:30517741 NCBI chr 8:106,876,514...106,889,852
Ensembl chr 8:106,876,514...106,889,917
JBrowse link
G Alb albumin affects binding ISO Isoniazid binds to ALB protein CTD PMID:25489718 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Apoa4 apolipoprotein A4 affects response to substance ISO APOA4 affects the susceptibility to Isoniazid CTD PMID:24848797 NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469
JBrowse link
G Apoa5 apolipoprotein A5 multiple interactions
decreases expression
EXP [Zidovudine co-treated with Isoniazid] results in decreased expression of APOA5 mRNA; silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of APOA5 mRNA]
Isoniazid results in decreased expression of APOA5 mRNA
CTD PMID:28619387 NCBI chr 8:46,561,180...46,563,818
Ensembl chr 8:46,561,229...46,563,816
JBrowse link
G App amyloid beta precursor protein increases expression ISO Isoniazid results in increased expression of APP mRNA CTD PMID:30008028 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Asl argininosuccinate lyase increases activity
multiple interactions
EXP Isoniazid results in increased activity of ASL protein
[Isoniazid co-treated with Zidovudine] results in increased activity of ASL protein; Silybin inhibits the reaction [[Isoniazid co-treated with Zidovudine] results in increased activity of ASL protein]
CTD PMID:28619387 NCBI chr12:26,659,664...26,677,136
Ensembl chr12:26,659,565...26,679,662
JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 increases expression ISO Isoniazid results in increased expression of ATP1B1 mRNA CTD PMID:30008028 NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459
JBrowse link
G Atp5f1b ATP synthase F1 subunit beta affects expression ISO Isoniazid affects the expression of ATP5B mRNA CTD PMID:24848797 NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273
JBrowse link
G Atp5mc1 ATP synthase membrane subunit c locus 1 affects expression ISO Isoniazid affects the expression of ATP5G1 mRNA CTD PMID:24848797 NCBI chr10:81,024,056...81,026,780
Ensembl chr10:81,023,925...81,027,124
Ensembl chr10:81,023,925...81,027,124
JBrowse link
G Atp5mc3 ATP synthase membrane subunit c locus 3 affects expression ISO Isoniazid affects the expression of ATP5G3 mRNA CTD PMID:24848797 NCBI chr 3:58,810,535...58,813,185
Ensembl chr 3:58,810,535...58,814,279
JBrowse link
G Atp5pb ATP synthase peripheral stalk-membrane subunit b affects expression ISO Isoniazid affects the expression of ATP5PB mRNA CTD PMID:24848797 NCBI chr 2:193,424,138...193,435,418
Ensembl chr 2:193,424,047...193,435,418
JBrowse link
G Atp5pf ATP synthase peripheral stalk subunit F6 affects expression ISO Isoniazid affects the expression of ATP5J mRNA CTD PMID:24848797 NCBI chr11:23,881,594...23,889,581
Ensembl chr11:23,881,592...23,889,119
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO
EXP
[Isoniazid co-treated with Rifampin] results in increased expression of BAX protein; Ursodeoxycholic Acid inhibits the reaction [[Isoniazid co-treated with Rifampin] results in increased expression of BAX protein]
Isoniazid results in increased expression of BAX mRNA
Isoniazid results in increased expression of BAX protein
chrysin inhibits the reaction [Isoniazid results in increased expression of BAX protein]
Quercetin inhibits the reaction [Isoniazid results in increased expression of BAX protein]
CTD PMID:21419764 PMID:31332904 PMID:33121995 PMID:33771660 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bbox1 gamma-butyrobetaine hydroxylase 1 increases expression ISO Isoniazid results in increased expression of BBOX1 mRNA CTD PMID:30008028 NCBI chr 3:96,822,654...96,871,786
Ensembl chr 3:96,822,655...96,871,458
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO [Isoniazid co-treated with Rifampin] results in decreased expression of BCL2 protein; Ursodeoxycholic Acid inhibits the reaction [[Isoniazid co-treated with Rifampin] results in decreased expression of BCL2 protein]
Isoniazid results in decreased expression of BCL2 mRNA
Isoniazid results in decreased expression of BCL2 protein
Quercetin inhibits the reaction [Isoniazid results in decreased expression of BCL2 protein]
CTD PMID:21419764 PMID:31332904 PMID:33771660 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases cleavage
ISO [Isoniazid co-treated with Rifampin] results in increased activity of CASP3 protein; HGF protein inhibits the reaction [[Isoniazid co-treated with Rifampin] results in increased activity of CASP3 protein]; Ursodeoxycholic Acid inhibits the reaction [[Isoniazid co-treated with Rifampin] results in increased activity of CASP3 protein]
Isoniazid results in increased expression of CASP3 mRNA
Isoniazid results in increased cleavage of CASP3 protein
acadesine promotes the reaction [Isoniazid results in increased cleavage of CASP3 protein]; Quercetin inhibits the reaction [Isoniazid results in increased cleavage of CASP3 protein]
CTD PMID:21419764 PMID:23764483 PMID:28556920 PMID:31332904 PMID:33771660 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 increases cleavage
multiple interactions
ISO Isoniazid results in increased cleavage of CASP9 protein
Quercetin inhibits the reaction [Isoniazid results in increased cleavage of CASP9 protein]
CTD PMID:31332904 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Casr calcium-sensing receptor affects expression EXP Isoniazid affects the expression of CASR mRNA CTD PMID:20623750 NCBI chr11:64,235,251...64,304,811
Ensembl chr11:64,235,251...64,304,811
JBrowse link
G Cat catalase decreases activity
multiple interactions
EXP
ISO
Isoniazid results in decreased activity of CAT protein
chrysin inhibits the reaction [Isoniazid results in decreased activity of CAT protein]
CTD PMID:33121995 PMID:33771660 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 decreases expression EXP Isoniazid results in decreased expression of CCR2 mRNA CTD PMID:20623750 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression ISO Isoniazid results in decreased expression of CEBPA mRNA; Isoniazid results in decreased expression of CEBPA protein CTD PMID:24128855 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta decreases expression ISO Isoniazid results in decreased expression of CEBPB protein CTD PMID:24128855 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta decreases expression ISO Isoniazid results in decreased expression of CEBPD mRNA; Isoniazid results in decreased expression of CEBPD protein CTD PMID:24128855 NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829
JBrowse link
G Chpt1 choline phosphotransferase 1 affects response to substance ISO CHPT1 affects the susceptibility to Isoniazid CTD PMID:24848797 NCBI chr 7:22,866,455...22,915,111
Ensembl chr 7:22,863,027...22,915,103
JBrowse link
G Cldn2 claudin 2 increases expression ISO Isoniazid results in increased expression of CLDN2 mRNA CTD PMID:30008028 NCBI chr  X:103,459,870...103,473,794
Ensembl chr  X:103,459,780...103,474,838
JBrowse link
G Cox11 cytochrome c oxidase copper chaperone COX11 affects expression ISO Isoniazid affects the expression of COX11 mRNA CTD PMID:24848797 NCBI chr10:75,458,735...75,465,322
Ensembl chr10:75,458,749...75,465,322
JBrowse link
G Cox17 cytochrome c oxidase copper chaperone COX17 affects expression ISO Isoniazid affects the expression of COX17 mRNA CTD PMID:24848797 NCBI chr11:62,400,733...62,406,507 JBrowse link
G Cox5b cytochrome c oxidase subunit 5B affects expression ISO Isoniazid affects the expression of COX5B mRNA CTD PMID:24848797 NCBI chr 9:38,921,980...38,923,806
Ensembl chr 9:38,921,967...38,925,052
JBrowse link
G Cox6a1 cytochrome c oxidase subunit 6A1 affects expression ISO Isoniazid affects the expression of COX6A1 mRNA CTD PMID:24848797 NCBI chr12:41,261,983...41,265,037
Ensembl chr12:41,261,967...41,265,041
JBrowse link
G Cox6b1 cytochrome c oxidase subunit 6B1 affects expression ISO Isoniazid affects the expression of COX6B1 mRNA CTD PMID:24848797 NCBI chr 1:85,875,080...85,884,081
Ensembl chr 1:85,875,109...85,884,001
JBrowse link
G Cox7a2 cytochrome c oxidase subunit 7A2 affects expression ISO Isoniazid affects the expression of COX7A2 mRNA CTD PMID:24848797 NCBI chr 8:80,716,824...80,720,922 JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A affects expression ISO Isoniazid affects the expression of CPT1A mRNA CTD PMID:24848797 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases secretion ISO Isoniazid results in increased secretion of CXCL10 protein CTD PMID:28444390 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cyb5a cytochrome b5 type A multiple interactions
decreases expression
EXP [Zidovudine co-treated with Isoniazid] results in decreased expression of CYB5A mRNA; silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of CYB5A mRNA]
Isoniazid results in decreased expression of CYB5A mRNA
CTD PMID:28619387 NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535
Ensembl chr18:78,202,342...78,258,535
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 increases expression EXP Isoniazid results in increased expression of CYP27A1 mRNA CTD PMID:32673658 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity
multiple interactions
ISO Isoniazid results in decreased activity of CYP2C8 protein
torsemide inhibits the reaction [Isoniazid results in decreased activity of CYP2C8 protein]
CTD PMID:15304522
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 affects response to substance
increases response to substance
multiple interactions
increases activity
increases expression
increases metabolic processing
ISO
EXP
CYP2E1 gene polymorphism affects the susceptibility to Isoniazid; CYP2E1 gene SNP affects the susceptibility to Isoniazid
CYP2E1 protein results in increased susceptibility to Isoniazid
GSTM1 protein inhibits the reaction [CYP2E1 protein results in increased susceptibility to Isoniazid]
Isoniazid results in increased activity of CYP2E1 protein
Berberine inhibits the reaction [Isoniazid results in increased expression of CYP2E1 mRNA]
Isoniazid results in increased expression of CYP2E1; Isoniazid results in increased expression of CYP2E1 mRNA; Isoniazid results in increased expression of CYP2E1 protein
2-(allylthio)pyrazine inhibits the reaction [Isoniazid results in increased expression of CYP2E1 protein]; [Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein; [Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA; [Isoniazid results in increased activity of CYP2E1 protein] which results in increased metabolism of 4-dichlorobenzene; [Isoniazid results in increased expression of CYP2E1] which results in increased metabolism of Acetaminophen; [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]; [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA]; diphenyleneiodonium inhibits the reaction [Isoniazid results in increased activity of CYP2E1 protein]; Isoniazid inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; Isoniazid results in increased expression of and results in increased activity of CYP2E1 protein; Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]; Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA]; Rifampin inhibits the reaction [Isoniazid results in increased expression of CYP2E1 protein]; Thiram inhibits the reaction [Isoniazid results in increased activity of CYP2E1 protein]; Tiopronin inhibits the reaction [Isoniazid results in increased activity of CYP2E1 protein]
CYP2E1 protein results in increased metabolism of Isoniazid
CTD PMID:3113478 PMID:7710944 PMID:8074729 PMID:9051121 PMID:9065729 More... NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
decreases activity
increases response to substance
EXP
ISO
[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA; [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA]; [SOD2 co-treated with CYP3A4] affects the susceptibility to Isoniazid; Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA]
Isoniazid results in decreased activity of CYP3A4 protein
CYP3A4 protein results in increased susceptibility to Isoniazid
CTD PMID:15005856 PMID:15304522 PMID:19501153 PMID:21540358 PMID:27919644 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression
increases activity
multiple interactions
EXP Isoniazid results in increased expression of CYP3A23-3A1 mRNA
Isoniazid results in increased activity of CYP3A23-3A1 protein
diphenyleneiodonium inhibits the reaction [Isoniazid results in increased activity of CYP3A23-3A1 protein]
CTD PMID:12883083 PMID:26880746 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions
increases expression
EXP
ISO
[Lipopolysaccharides co-treated with Isoniazid] results in increased expression of CYP7A1 mRNA; obeticholic acid inhibits the reaction [Isoniazid results in increased expression of CYP7A1 mRNA]
[Isoniazid co-treated with Vitamin B 6] results in increased expression of CYP7A1 mRNA
CTD PMID:25331106 PMID:32673658 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
decreases expression
EXP
ISO
Isoniazid results in increased expression of DDIT3 mRNA
Isoniazid results in decreased expression of DDIT3 mRNA
CTD PMID:12883083 PMID:30008028 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Depp1 DEPP1, autophagy regulator increases expression ISO Isoniazid results in increased expression of DEPP1 mRNA CTD PMID:17175557 NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542
JBrowse link
G Epx eosinophil peroxidase increases oxidation
multiple interactions
ISO EPX protein results in increased oxidation of Isoniazid
[EPX protein results in increased oxidation of Isoniazid] which results in increased chemical synthesis of isonicotinyl-NAD
CTD PMID:30922765 NCBI chr10:72,666,865...72,677,952
Ensembl chr10:72,666,865...72,677,952
JBrowse link
G Fech ferrochelatase decreases expression ISO Isoniazid results in decreased expression of FECH protein CTD PMID:27438535 PMID:30517741 NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha decreases expression EXP Isoniazid results in decreased expression of GADD45A mRNA CTD PMID:20623750 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase increases expression EXP Isoniazid results in increased expression of GAPDH mRNA CTD PMID:12883083 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression
decreases expression
ISO
EXP
Isoniazid inhibits the reaction [2-tert-butylhydroquinone results in increased expression of GCLC mRNA]
Isoniazid results in increased expression of GCLC mRNA
chrysin inhibits the reaction [Isoniazid results in increased expression of GCLC mRNA]
Isoniazid results in decreased expression of GCLC mRNA
CTD PMID:24128855 PMID:33121995 PMID:33771660 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit decreases expression
increases expression
multiple interactions
ISO
EXP
Isoniazid results in decreased expression of GCLM mRNA
Isoniazid results in increased expression of GCLM mRNA
chrysin inhibits the reaction [Isoniazid results in increased expression of GCLM mRNA]
CTD PMID:30008028 PMID:33121995 PMID:33771660 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions
increases expression
EXP chrysin inhibits the reaction [Isoniazid results in increased expression of GFAP mRNA]; chrysin inhibits the reaction [Isoniazid results in increased expression of GFAP protein]
Isoniazid results in increased expression of GFAP mRNA; Isoniazid results in increased expression of GFAP protein
CTD PMID:33121995 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions EXP [Lipopolysaccharides co-treated with Isoniazid] results in increased activity of GGT1 protein CTD PMID:25331106 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity
multiple interactions
increases expression
EXP
ISO
Isoniazid results in increased activity of GPT protein
Quercetin inhibits the reaction [Isoniazid results in increased expression of GPT protein]
[Lipopolysaccharides co-treated with Isoniazid] results in increased activity of GPT protein; Isoniazid promotes the reaction [Zidovudine results in increased activity of GPT protein]; silybin inhibits the reaction [Isoniazid promotes the reaction [Zidovudine results in increased activity of GPT protein]]
CTD PMID:25331106 PMID:28619387 PMID:31332904 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression EXP Isoniazid results in increased expression of GSTA2 mRNA CTD PMID:12883083 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions
decreases response to substance
ISO GSTM1 protein inhibits the reaction [CYP2E1 protein results in increased susceptibility to Isoniazid]
GSTM1 protein results in decreased susceptibility to Isoniazid
CTD PMID:28762043 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases expression EXP Isoniazid results in decreased expression of GSTP1 mRNA CTD PMID:20623750 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Gstt1 glutathione S-transferase theta 1 multiple interactions ISO GSTT1 gene polymorphism affects the susceptibility to [Isoniazid co-treated with Rifampin]; GSTT1 gene polymorphism results in increased susceptibility to [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide] CTD PMID:18397238 PMID:20485159 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 affects expression EXP Isoniazid affects the expression of HAVCR1 mRNA CTD PMID:20623750 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
JBrowse link
G Hgf hepatocyte growth factor multiple interactions ISO HGF protein inhibits the reaction [[Isoniazid co-treated with Rifampin] results in increased abundance of Reactive Oxygen Species]; HGF protein inhibits the reaction [[Isoniazid co-treated with Rifampin] results in increased activity of CASP3 protein] CTD PMID:23764483 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
decreases expression
ISO
EXP
Isoniazid inhibits the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 mRNA]
Isoniazid results in increased expression of HMOX1 mRNA
chrysin inhibits the reaction [Isoniazid results in increased expression of HMOX1 mRNA]
Isoniazid results in decreased expression of HMOX1 mRNA
CTD PMID:24128855 PMID:33121995 PMID:33771660 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hmox2 heme oxygenase 2 increases expression EXP Isoniazid results in increased expression of HMOX2 mRNA CTD PMID:12883083 NCBI chr10:10,797,076...10,831,178
Ensembl chr10:10,797,055...10,831,148
JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 increases expression EXP Isoniazid results in increased expression of HPRT1 mRNA CTD PMID:12883083 NCBI chr  X:132,736,175...132,768,149
Ensembl chr  X:132,736,096...132,768,154
JBrowse link
G Ifng interferon gamma increases secretion ISO Isoniazid results in increased secretion of IFNG protein CTD PMID:28444390 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 increases secretion ISO Isoniazid results in increased secretion of IL10 protein CTD PMID:28444390 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il12a interleukin 12A increases secretion ISO Isoniazid results in increased secretion of IL12A protein CTD PMID:28444390 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
JBrowse link
G Il12b interleukin 12B increases secretion ISO Isoniazid results in increased secretion of IL12B protein CTD PMID:28444390 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il17a interleukin 17A increases secretion ISO Isoniazid results in increased secretion of IL17A protein CTD PMID:28444390 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il1a interleukin 1 alpha increases secretion
increases expression
ISO Isoniazid results in increased secretion of IL1A protein
Isoniazid results in increased expression of IL1A mRNA
CTD PMID:28444390 PMID:32816093 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta increases secretion
multiple interactions
increases expression
ISO
EXP
Isoniazid results in increased secretion of IL1B protein
chrysin inhibits the reaction [Isoniazid results in increased expression of IL1B mRNA]
CTD PMID:28444390 PMID:32816093 PMID:33121995 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Isoniazid co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA CTD PMID:29594315 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il24 interleukin 24 increases expression ISO Isoniazid results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
increases secretion
ISO
EXP
Isoniazid results in increased expression of IL6 protein
Isoniazid results in increased expression of IL6 mRNA
chrysin inhibits the reaction [Isoniazid results in increased expression of IL6 mRNA]
Isoniazid results in increased secretion of IL6 protein
CTD PMID:19575532 PMID:28444390 PMID:33121995 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Isoniazid results in increased expression of INHBE mRNA CTD PMID:17175557 NCBI chr 7:63,177,558...63,178,983
Ensembl chr 7:63,176,219...63,179,172
JBrowse link
G Izumo1r IZUMO1 receptor, JUNO decreases expression ISO Isoniazid results in decreased expression of IZUMO1R protein CTD PMID:33771660 NCBI chr 8:11,744,383...11,746,872
Ensembl chr 8:11,725,863...11,748,465
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 decreases expression ISO Isoniazid results in decreased expression of KEAP1 mRNA CTD PMID:33771660 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 affects response to substance ISO LAMP1 affects the susceptibility to Isoniazid CTD PMID:24848797 NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883
JBrowse link
G Lcn2 lipocalin 2 increases expression EXP Isoniazid results in increased expression of LCN2 mRNA CTD PMID:20623750 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Map2 microtubule-associated protein 2 affects expression ISO Isoniazid affects the expression of MAP2 mRNA CTD PMID:22131109 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
multiple interactions
ISO Isoniazid results in decreased phosphorylation of MAPK1 protein
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Quercetin inhibits the reaction [Isoniazid results in decreased phosphorylation of MAPK1 protein]]; Quercetin inhibits the reaction [Isoniazid results in decreased phosphorylation of MAPK1 protein]
CTD PMID:31332904 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Quercetin inhibits the reaction [Isoniazid results in decreased phosphorylation of MAPK3 protein]]; Quercetin inhibits the reaction [Isoniazid results in decreased phosphorylation of MAPK3 protein] CTD PMID:31332904 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 increases expression ISO Isoniazid results in increased expression of MGST1 mRNA CTD PMID:33771660 NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892
JBrowse link
G Mir106b microRNA 106b decreases expression EXP Isoniazide decreased expression of miR106b miRNA in the liver RGD PMID:29554950 RGD:15042854 NCBI chr12:17,043,344...17,043,425
Ensembl chr12:17,043,344...17,043,425
JBrowse link
G Mpo myeloperoxidase multiple interactions
increases oxidation
ISO [[MPO protein results in increased oxidation of Isoniazid] which results in increased chemical synthesis of Free Radicals] which results in increased chemical synthesis of isonicotinyl-NAD; [MPO protein results in increased oxidation of Isoniazid] which results in increased chemical synthesis of Free Radicals; [MPO protein results in increased oxidation of Isoniazid] which results in increased chemical synthesis of isonicotinyl-NAD CTD PMID:26867495 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mt-co3 mitochondrially encoded cytochrome c oxidase III increases expression EXP Isoniazid results in increased expression of COX3 mRNA CTD PMID:12883083 NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382
JBrowse link
G Muc1 mucin 1, cell surface associated increases expression ISO Isoniazid results in increased expression of MUC1 mRNA CTD PMID:30008028 NCBI chr 2:174,635,559...174,640,738
Ensembl chr 2:174,635,995...174,640,733
JBrowse link
G Nat2 N-acetyltransferase 2 increases acetylation
multiple interactions
decreases expression
decreases acetylation
increases metabolic processing
affects metabolic processing
affects response to substance
ISO
EXP
NAT2 protein polymorphism results in increased acetylation of Isoniazid; NAT2 protein results in increased acetylation of Isoniazid
[Zidovudine co-treated with Isoniazid] results in decreased expression of NAT2 mRNA; silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of NAT2 mRNA]
Isoniazid results in decreased expression of NAT2 mRNA
[NAT2 gene polymorphism results in decreased acetylation of Isoniazid] which results in decreased abundance of acetylisoniazid; [NAT2 gene polymorphism results in decreased metabolism of Isoniazid] which results in increased abundance of hydrazine
NAT2 protein results in increased metabolism of Isoniazid
NAT2 protein affects the metabolism of Isoniazid; NAT2 protein polymorphism affects the metabolism of Isoniazid
NAT2 gene polymorphism affects the susceptibility to Isoniazid; NAT2 gene SNP affects the susceptibility to Isoniazid
CTD PMID:11379777 PMID:11915035 PMID:15546075 PMID:15565348 PMID:15618686 More... NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
JBrowse link
G Ncr3lg1 natural killer cell cytotoxicity receptor 3 ligand 1 increases expression ISO Isoniazid results in increased expression of NCR3LG1 mRNA; Isoniazid results in increased expression of NCR3LG1 protein CTD PMID:32060585 NCBI chr 1:96,565,664...96,581,825 JBrowse link
G Ndufa1 NADH:ubiquinone oxidoreductase subunit A1 affects expression ISO Isoniazid affects the expression of NDUFA1 mRNA CTD PMID:24848797 NCBI chr  X:116,424,223...116,427,875
Ensembl chr  X:116,424,223...116,428,633
JBrowse link
G Ndufa10 NADH:ubiquinone oxidoreductase subunit A10 affects expression ISO Isoniazid affects the expression of NDUFA10 mRNA CTD PMID:24848797 NCBI chr 9:93,007,034...93,041,825
Ensembl chr 9:93,007,042...93,042,560
JBrowse link
G Ndufa12 NADH:ubiquinone oxidoreductase subunit A12 affects expression ISO Isoniazid affects the expression of NDUFA12 mRNA CTD PMID:24848797 NCBI chr 7:28,771,330...28,798,316
Ensembl chr 7:28,771,330...28,798,315
JBrowse link
G Ndufa13 NADH:ubiquinone oxidoreductase subunit A13 affects expression ISO Isoniazid affects the expression of NDUFA13 mRNA CTD PMID:24848797 NCBI chr16:19,526,633...19,533,567
Ensembl chr16:19,526,565...19,535,726
JBrowse link
G Ndufa4 NDUFA4, mitochondrial complex associated affects expression ISO Isoniazid affects the expression of NDUFA4 mRNA CTD PMID:24848797 NCBI chr 4:40,002,216...40,009,384
Ensembl chr 4:40,002,216...40,023,920
JBrowse link
G Ndufa5 NADH:ubiquinone oxidoreductase subunit A5 affects expression ISO Isoniazid affects the expression of NDUFA5 mRNA CTD PMID:24848797 NCBI chr 4:52,997,327...53,005,685
Ensembl chr 4:52,995,546...53,005,598
JBrowse link
G Ndufa8 NADH:ubiquinone oxidoreductase subunit A8 affects expression ISO Isoniazid affects the expression of NDUFA8 mRNA CTD PMID:24848797 NCBI chr 3:19,386,063...19,402,093
Ensembl chr 3:19,386,065...19,402,071
JBrowse link
G Ndufa9 NADH:ubiquinone oxidoreductase subunit A9 affects expression ISO Isoniazid affects the expression of NDUFA9 mRNA CTD PMID:24848797 NCBI chr 4:159,659,242...159,688,034
Ensembl chr 4:159,659,242...159,688,018
JBrowse link
G Ndufab1 NADH:ubiquinone oxidoreductase subunit AB1 affects expression ISO Isoniazid affects the expression of NDUFAB1 mRNA CTD PMID:24848797 NCBI chr 1:176,644,696...176,658,131
Ensembl chr 1:176,644,703...176,658,099
JBrowse link
G Ndufb10 NADH:ubiquinone oxidoreductase subunit B10 affects expression ISO Isoniazid affects the expression of NDUFB10 mRNA CTD PMID:24848797 NCBI chr10:13,749,273...13,751,434
Ensembl chr10:13,749,275...13,751,442
JBrowse link
G Ndufb2 NADH:ubiquinone oxidoreductase subunit B2 affects expression ISO Isoniazid affects the expression of NDUFB2 mRNA CTD PMID:24848797 NCBI chr 4:68,367,526...68,374,609
Ensembl chr15:46,536,062...46,536,851
JBrowse link
G Ndufb3 NADH:ubiquinone oxidoreductase subunit B3 affects expression ISO Isoniazid affects the expression of NDUFB3 mRNA CTD PMID:24848797 NCBI chr 9:60,129,240...60,139,452
Ensembl chr 9:60,129,154...60,139,446
JBrowse link
G Ndufb5 NADH:ubiquinone oxidoreductase subunit B5 affects expression ISO Isoniazid affects the expression of NDUFB5 mRNA CTD PMID:24848797 NCBI chr 2:115,519,248...115,533,589
Ensembl chr 2:115,519,154...115,533,589
JBrowse link
G Ndufb6 NADH:ubiquinone oxidoreductase subunit B6 affects expression ISO Isoniazid affects the expression of NDUFB6 mRNA CTD PMID:24848797 NCBI chr 5:55,400,543...55,410,110
Ensembl chr 5:55,400,543...55,410,181
JBrowse link
G Ndufb7 NADH:ubiquinone oxidoreductase subunit B7 affects expression ISO Isoniazid affects the expression of NDUFB7 mRNA CTD PMID:24848797 NCBI chr19:24,568,241...24,572,579
Ensembl chr19:24,568,241...24,572,579
JBrowse link
G Ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 affects expression ISO Isoniazid affects the expression of NDUFS1 mRNA CTD PMID:24848797 NCBI chr 9:64,546,430...64,579,751
Ensembl chr 9:64,546,225...64,579,893
JBrowse link
G Ndufs2 NADH:ubiquinone oxidoreductase core subunit S2 affects expression ISO Isoniazid affects the expression of NDUFS2 mRNA CTD PMID:24848797 NCBI chr13:83,654,402...83,671,474
Ensembl chr13:83,654,406...83,671,420
JBrowse link
G Ndufs3 NADH:ubiquinone oxidoreductase core subunit S3 affects expression ISO Isoniazid affects the expression of NDUFS3 mRNA CTD PMID:24848797 NCBI chr 3:76,876,646...76,883,824
Ensembl chr 3:76,876,646...76,883,824
JBrowse link
G Ndufs4 NADH:ubiquinone oxidoreductase subunit S4 affects expression ISO Isoniazid affects the expression of NDUFS4 mRNA CTD PMID:24848797 NCBI chr 2:45,951,327...46,061,829
Ensembl chr 2:45,951,313...46,061,846
JBrowse link
G Ndufs8 NADH:ubiquinone oxidoreductase core subunit S8 affects expression ISO Isoniazid affects the expression of NDUFS8 mRNA CTD PMID:24848797 NCBI chr 1:201,140,585...201,144,573
Ensembl chr 1:201,140,585...201,144,511
JBrowse link
G Ndufv1 NADH:ubiquinone oxidoreductase core subunit V1 affects expression ISO Isoniazid affects the expression of NDUFV1 mRNA CTD PMID:24848797 NCBI chr 1:201,300,365...201,305,461
Ensembl chr 1:201,299,985...201,305,466
JBrowse link
G Ndufv2 NADH:ubiquinone oxidoreductase core subunit V2 affects expression ISO Isoniazid affects the expression of NDUFV2 mRNA CTD PMID:24848797 NCBI chr 9:105,690,454...105,710,669
Ensembl chr 9:105,690,455...105,710,713
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases activity
increases expression
multiple interactions
ISO
EXP
Isoniazid results in increased activity of NFE2L2 protein
Isoniazid results in increased expression of NFE2L2 mRNA
chrysin inhibits the reaction [Isoniazid results in increased expression of NFE2L2 mRNA]
CTD PMID:30203046 PMID:33121995 PMID:33771660 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression
multiple interactions
EXP Isoniazid results in increased expression of NFKB1 mRNA
chrysin inhibits the reaction [Isoniazid results in increased expression of NFKB1 mRNA]
CTD PMID:33121995 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
decreases expression
ISO
EXP
Isoniazid inhibits the reaction [2-tert-butylhydroquinone results in increased expression of NQO1 mRNA]
Isoniazid results in increased expression of NQO1 mRNA
chrysin inhibits the reaction [Isoniazid results in increased expression of NQO1 mRNA]
Isoniazid results in decreased expression of NQO1 mRNA
CTD PMID:24128855 PMID:28444390 PMID:33121995 PMID:33771660 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases expression
multiple interactions
EXP
ISO
Isoniazid results in decreased expression of NR0B2 mRNA
[Isoniazid co-treated with Vitamin B 6] results in decreased expression of NR0B2 mRNA
obeticholic acid inhibits the reaction [Isoniazid results in decreased expression of NR0B2 mRNA]
CTD PMID:32673658 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
decreases expression
EXP
ISO
[Lipopolysaccharides co-treated with Isoniazid] results in decreased expression of NR1H4 mRNA; [Lipopolysaccharides co-treated with Isoniazid] results in decreased expression of NR1H4 protein; obeticholic acid inhibits the reaction [Isoniazid results in decreased expression of NR1H4 mRNA]
[Isoniazid co-treated with Vitamin B 6] results in decreased expression of NR1H4 mRNA
isoniazide decreases expression of nr1h4 protein in rat liver
CTD
RGD
PMID:25331106 PMID:32673658 PMID:30068870 RGD:15042870 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO Isoniazid results in increased activity of NR1I3 protein CTD PMID:30203046 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Nrf1 nuclear respiratory factor 1 multiple interactions
decreases expression
ISO acadesine inhibits the reaction [Isoniazid results in decreased expression of NRF1 protein] CTD PMID:28556920 NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Isoniazid results in increased expression of NUPR1 mRNA CTD PMID:17175557 NCBI chr 1:181,213,292...181,215,327 JBrowse link
G Ogdh oxoglutarate dehydrogenase affects expression ISO Isoniazid affects the expression of OGDH mRNA CTD PMID:24848797 NCBI chr14:81,150,021...81,217,479
Ensembl chr14:81,150,091...81,217,479
JBrowse link
G Park7 Parkinsonism associated deglycase affects expression ISO Isoniazid affects the expression of PARK7 mRNA CTD PMID:24848797 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 increases expression ISO Isoniazid results in increased expression of PID1 mRNA CTD PMID:32816093 NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044
JBrowse link
G Plod2 procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 increases expression ISO Isoniazid results in increased expression of PLOD2 mRNA CTD PMID:15997088 NCBI chr 8:93,084,548...93,167,255
Ensembl chr 8:93,084,513...93,167,255
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions
decreases expression
EXP [Zidovudine co-treated with Isoniazid] results in decreased expression of POR mRNA; silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of POR mRNA]
Isoniazid results in decreased expression of POR mRNA
CTD PMID:28619387 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases activity ISO Isoniazid results in increased activity of PPARA protein CTD PMID:30203046 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO Isoniazid results in decreased expression of PPARG mRNA
Isoniazid results in decreased expression of PPARG mRNA; Isoniazid results in decreased expression of PPARG protein
CTD PMID:24128855 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha decreases expression
multiple interactions
ISO Isoniazid results in decreased expression of PPARGC1A protein
acadesine inhibits the reaction [Isoniazid results in decreased expression of PPARGC1A protein]
CTD PMID:28556920 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Psen1 presenilin 1 affects expression ISO Isoniazid affects the expression of PSEN1 mRNA CTD PMID:24848797 NCBI chr 6:103,323,014...103,375,088
Ensembl chr 6:103,323,120...103,371,650
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO Isoniazid results in increased expression of PTGS2 mRNA CTD PMID:32816093 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Sdha succinate dehydrogenase complex flavoprotein subunit A affects expression ISO Isoniazid affects the expression of SDHA mRNA CTD PMID:24848797 NCBI chr 1:28,935,965...28,960,936
Ensembl chr 1:28,940,164...28,961,535
JBrowse link
G Sdhb succinate dehydrogenase complex iron sulfur subunit B affects expression ISO Isoniazid affects the expression of SDHB mRNA CTD PMID:24848797 NCBI chr 5:153,264,906...153,285,570
Ensembl chr 5:153,264,899...153,314,293
JBrowse link
G Sdhd succinate dehydrogenase complex subunit D affects expression ISO Isoniazid affects the expression of SDHD mRNA CTD PMID:24848797 NCBI chr 8:50,944,717...50,954,298
Ensembl chr 8:50,944,704...50,954,238
JBrowse link
G Sfn stratifin decreases expression ISO Isoniazid results in decreased expression of SFN mRNA CTD PMID:30008028 Ensembl chr 5:145,826,201...145,831,314 JBrowse link
G Sirt1 sirtuin 1 multiple interactions
decreases expression
ISO acadesine inhibits the reaction [Isoniazid results in decreased expression of SIRT1 protein]; Quercetin inhibits the reaction [Isoniazid results in decreased expression of SIRT1 protein] CTD PMID:28556920 PMID:31332904 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression
multiple interactions
EXP Isoniazid results in decreased expression of SLC10A1 mRNA
obeticholic acid promotes the reaction [Isoniazid results in decreased expression of SLC10A1 mRNA]
CTD PMID:32673658 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
JBrowse link
G Slc11a1 solute carrier family 11 member 1 affects expression EXP Isoniazid affects the expression of SLC11A1 mRNA CTD PMID:20623750 NCBI chr 9:75,957,193...75,968,115
Ensembl chr 9:75,957,316...75,968,101
JBrowse link
G Slc7a5 solute carrier family 7 member 5 decreases expression ISO Isoniazid results in decreased expression of SLC7A5 mRNA CTD PMID:30008028 NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823
JBrowse link
G Slco1a1 solute carrier organic anion transporter family, member 1a1 decreases expression EXP Isoniazid results in decreased expression of SLCO1B1 mRNA CTD PMID:32673658 NCBI chr 4:174,877,045...174,950,857
Ensembl chr 4:174,876,593...174,950,873
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Isoniazid results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
JBrowse link
G Sod1 superoxide dismutase 1 increases expression ISO Isoniazid results in increased expression of SOD1 mRNA CTD PMID:33771660 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
affects expression
EXP
ISO
[SOD2 co-treated with CYP3A4] affects the susceptibility to Isoniazid
Isoniazid affects the expression of SOD2 mRNA
CTD PMID:19501153 PMID:24848797 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Spp1 secreted phosphoprotein 1 affects expression
decreases expression
EXP
ISO
Isoniazid affects the expression of SPP1 mRNA
Isoniazid results in decreased expression of SPP1 mRNA
CTD PMID:20623750 PMID:30008028 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Isoniazid results in increased expression of SRXN1 mRNA CTD PMID:28444390 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
JBrowse link
G Surf1 SURF1, cytochrome c oxidase assembly factor affects expression ISO Isoniazid affects the expression of SURF1 mRNA CTD PMID:24848797 NCBI chr 3:10,241,793...10,244,686
Ensembl chr 3:10,241,837...10,263,315
JBrowse link
G Tf transferrin increases expression EXP Isoniazid results in increased expression of TF mRNA CTD PMID:12883083 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
JBrowse link
G Tmprss2 transmembrane serine protease 2 affects expression ISO Isoniazid affects the expression of TMPRSS2 mRNA CTD PMID:32808185 NCBI chr11:36,934,306...36,973,779
Ensembl chr11:36,934,306...36,973,715
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
increases secretion
EXP
ISO
Isoniazid results in increased expression of TNF protein
[Isoniazid co-treated with Zidovudine] results in increased expression of TNF protein; chrysin inhibits the reaction [Isoniazid results in increased expression of TNF protein]; Isoniazid promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Silybin inhibits the reaction [[Isoniazid co-treated with Zidovudine] results in increased expression of TNF protein]
Isoniazid results in increased secretion of TNF protein
CTD PMID:25331106 PMID:28444390 PMID:28619387 PMID:33121995 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tpo thyroid peroxidase decreases activity EXP Isoniazid results in decreased activity of TPO protein CTD PMID:26884060 NCBI chr 6:46,698,402...46,768,199
Ensembl chr 6:46,698,414...46,768,199
JBrowse link
G Trak1 trafficking kinesin protein 1 affects expression ISO Isoniazid affects the expression of TRAK1 mRNA CTD PMID:24848797 NCBI chr 8:120,984,445...121,139,357
Ensembl chr 8:120,984,431...121,139,367
JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression ISO Isoniazid results in increased expression of TRIB3 mRNA CTD PMID:30008028 NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497
JBrowse link
G Txn2 thioredoxin 2 affects expression ISO Isoniazid affects the expression of TXN2 mRNA CTD PMID:24848797 NCBI chr 7:109,496,772...109,510,378
Ensembl chr 7:109,496,761...109,510,359
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO Isoniazid results in increased expression of TXNRD1 mRNA CTD PMID:28444390 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
G Txnrd2 thioredoxin reductase 2 affects expression ISO Isoniazid affects the expression of TXNRD2 mRNA CTD PMID:24848797 NCBI chr11:82,519,996...82,568,156
Ensembl chr11:82,519,999...82,568,156
JBrowse link
G Uqcrb ubiquinol-cytochrome c reductase binding protein affects expression ISO Isoniazid affects the expression of UQCRB mRNA CTD PMID:24848797 NCBI chr 7:63,814,784...63,820,150
Ensembl chr 7:63,814,797...63,820,150
JBrowse link
G Uqcrc2 ubiquinol cytochrome c reductase core protein 2 affects expression ISO Isoniazid affects the expression of UQCRC2 mRNA CTD PMID:24848797 NCBI chr 1:175,167,933...175,198,499
Ensembl chr 1:175,167,894...175,199,453
JBrowse link
lomefloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects binding ISO lomefloxacin binds to KCNH2 protein CTD PMID:34058295 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
N'-acetylisoniazid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mpo myeloperoxidase increases oxidation ISO MPO protein results in increased oxidation of (N)1-acetylisoniazid CTD PMID:26867495 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
pomalidomide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brd4 bromodomain containing 4 multiple interactions ISO pomalidomide inhibits the reaction [ARV-825 results in increased degradation of BRD4 protein] CTD PMID:26051217 NCBI chr 7:11,216,446...11,296,029
Ensembl chr 7:11,216,446...11,295,539
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [afuresertib co-treated with pomalidomide co-treated with Dexamethasone] results in increased cleavage of CASP3 protein CTD PMID:29928335 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [afuresertib co-treated with pomalidomide co-treated with Dexamethasone] results in increased cleavage of CASP8 protein CTD PMID:29928335 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases secretion ISO pomalidomide results in increased secretion of CCL2 protein CTD PMID:15292067 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha increases expression ISO pomalidomide results in increased expression of CEBPA mRNA CTD PMID:15292067 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta increases expression ISO pomalidomide results in increased expression of CEBPD mRNA CTD PMID:15292067 NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829
JBrowse link
G Cebpe CCAAT/enhancer binding protein epsilon increases expression ISO pomalidomide results in increased expression of CEBPE mRNA CTD PMID:15292067 NCBI chr15:28,169,885...28,171,283
Ensembl chr15:28,169,704...28,171,814
JBrowse link
G Crbn cereblon multiple interactions
affects binding
increases response to substance
ISO [pomalidomide co-treated with Dexamethasone co-treated with afuresertib] results in increased expression of CRBN protein; [pomalidomide co-treated with Dexamethasone] results in increased expression of CRBN protein; pomalidomide inhibits the reaction [CRBN protein binds to and results in increased ubiquitination of and results in increased degradation of MEIS2 protein]
pomalidomide binds to [SALL4 protein binds to CRBN protein]
CRBN results in increased susceptibility to pomalidomide
CTD PMID:25043012 PMID:26186254 PMID:29928335 PMID:30067223 NCBI chr 4:139,701,154...139,719,949
Ensembl chr 4:139,701,094...139,719,938
JBrowse link
G Csf2 colony stimulating factor 2 decreases secretion ISO pomalidomide results in decreased secretion of CSF2 protein CTD PMID:15292067 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Csf3 colony stimulating factor 3 increases secretion ISO pomalidomide results in increased secretion of CSF3 protein CTD PMID:15292067 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases oxidation ISO CYP2C19 protein results in increased oxidation of pomalidomide CTD PMID:24350712 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 increases oxidation ISO CYP2J2 protein results in increased oxidation of pomalidomide CTD PMID:24350712 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases oxidation ISO CYP3A4 protein results in increased oxidation of pomalidomide CTD PMID:24350712 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Dtwd1 DTW domain containing 1 multiple interactions ISO pomalidomide results in increased degradation of and results in decreased expression of DTWD1 protein CTD PMID:30067223 NCBI chr 3:113,392,402...113,409,322
Ensembl chr 3:113,392,457...113,408,105
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO [pomalidomide co-treated with Dexamethasone] results in decreased phosphorylation of EIF4EBP1 protein; afuresertib promotes the reaction [[pomalidomide co-treated with Dexamethasone] results in decreased phosphorylation of EIF4EBP1 protein] CTD PMID:29928335 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Fam83f family with sequence similarity 83, member F multiple interactions ISO pomalidomide results in increased degradation of and results in decreased expression of FAM83F protein CTD PMID:30067223 NCBI chr 7:112,211,164...112,240,454
Ensembl chr 7:112,211,164...112,240,452
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 decreases expression ISO pomalidomide results in decreased expression of FGFR1 mRNA CTD PMID:30834740 NCBI chr16:66,492,445...66,546,731
Ensembl chr16:66,494,042...66,547,350
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 affects expression ISO pomalidomide affects the expression of FGFR3 mRNA CTD PMID:30834740 NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341
JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO [pomalidomide co-treated with Dexamethasone] affects the phosphorylation of FOXO1 protein; afuresertib affects the reaction [[pomalidomide co-treated with Dexamethasone] affects the phosphorylation of FOXO1 protein] CTD PMID:29928335 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
JBrowse link
G Gata1 GATA binding protein 1 decreases expression ISO pomalidomide results in decreased expression of GATA1 mRNA; pomalidomide results in decreased expression of GATA1 protein CTD PMID:15292067 NCBI chr  X:14,529,706...14,537,530
Ensembl chr  X:14,529,702...14,537,530
JBrowse link
G Gata2 GATA binding protein 2 decreases expression ISO pomalidomide results in decreased expression of GATA2 mRNA CTD PMID:15292067 NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761
JBrowse link
G Gfi1 growth factor independent 1 transcriptional repressor increases expression ISO pomalidomide results in increased expression of GFI1 mRNA CTD PMID:15292067 NCBI chr14:2,040,576...2,056,874
Ensembl chr14:2,042,434...2,051,814
JBrowse link
G Gfi1b growth factor independent 1B transcriptional repressor decreases expression ISO pomalidomide results in decreased expression of GFI1B mRNA CTD PMID:15292067 NCBI chr 3:11,940,232...11,952,989
Ensembl chr 3:11,940,233...11,952,942
JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein increases expression ISO pomalidomide results in increased expression of ID1 mRNA CTD PMID:15292067 NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419
JBrowse link
G Id2 inhibitor of DNA binding 2 increases expression ISO pomalidomide results in increased expression of ID2 mRNA CTD PMID:15292067 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
JBrowse link
G Ikzf1 IKAROS family zinc finger 1 multiple interactions ISO [pomalidomide co-treated with Dexamethasone] results in decreased expression of IKZF1 protein; afuresertib promotes the reaction [[pomalidomide co-treated with Dexamethasone] results in decreased expression of IKZF1 protein] CTD PMID:29928335 NCBI chr14:86,255,065...86,340,839
Ensembl chr14:86,255,065...86,342,416
JBrowse link
G Ikzf3 IKAROS family zinc finger 3 multiple interactions ISO [pomalidomide co-treated with Dexamethasone] results in decreased expression of IKZF3 protein; afuresertib promotes the reaction [[pomalidomide co-treated with Dexamethasone] results in decreased expression of IKZF3 protein] CTD PMID:29928335 NCBI chr10:83,460,564...83,553,591
Ensembl chr10:83,465,745...83,553,591
JBrowse link
G Il10 interleukin 10 increases secretion ISO pomalidomide results in increased secretion of IL10 protein CTD PMID:15292067 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il13 interleukin 13 decreases secretion ISO pomalidomide results in decreased secretion of IL13 protein CTD PMID:15292067 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il2 interleukin 2 multiple interactions ISO Go 6976 inhibits the reaction [pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]]; pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 mRNA]; pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]; pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased secretion of IL2 protein]; rottlerin inhibits the reaction [pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]] CTD PMID:16241859 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il5 interleukin 5 decreases secretion ISO pomalidomide results in decreased secretion of IL5 protein CTD PMID:15292067 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Irf4 interferon regulatory factor 4 multiple interactions ISO [pomalidomide co-treated with Dexamethasone co-treated with afuresertib] results in decreased expression of IRF4 protein; [pomalidomide co-treated with Dexamethasone] results in decreased expression of IRF4 protein CTD PMID:29928335 NCBI chr17:33,721,800...33,742,570
Ensembl chr17:33,721,811...33,740,070
JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit decreases expression ISO pomalidomide results in decreased expression of JUND mRNA CTD PMID:15292067 NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799
JBrowse link
G Klf1 Kruppel like factor 1 decreases expression ISO pomalidomide results in decreased expression of KLF1 mRNA CTD PMID:15292067 NCBI chr19:23,250,627...23,253,802
Ensembl chr19:23,250,631...23,253,758
JBrowse link
G Lmo2 LIM domain only 2 decreases expression ISO pomalidomide results in decreased expression of LMO2 mRNA CTD PMID:15292067 NCBI chr 3:90,355,234...90,377,970
Ensembl chr 3:90,365,883...90,377,953
JBrowse link
G Meis2 Meis homeobox 2 multiple interactions ISO pomalidomide inhibits the reaction [CRBN protein binds to and results in increased ubiquitination of and results in increased degradation of MEIS2 protein] CTD PMID:25043012 NCBI chr 3:102,742,905...102,944,833
Ensembl chr 3:102,742,900...102,949,696
JBrowse link
G Nfe2 nuclear factor, erythroid 2 decreases expression ISO pomalidomide results in decreased expression of NFE2 mRNA CTD PMID:15292067 NCBI chr 7:134,382,758...134,395,364
Ensembl chr 7:134,382,761...134,390,108
JBrowse link
G Prkcq protein kinase C, theta multiple interactions ISO pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased activity of PRKCQ protein] CTD PMID:16241859 NCBI chr17:67,246,394...67,379,049
Ensembl chr17:67,246,394...67,378,704
JBrowse link
G Rab28 RAB28, member RAS oncogene family multiple interactions ISO pomalidomide results in increased degradation of and results in decreased expression of RAB28 protein CTD PMID:30067223 NCBI chr14:69,245,846...69,322,968
Ensembl chr14:69,245,854...69,322,967
JBrowse link
G Sall4 spalt-like transcription factor 4 affects binding
multiple interactions
ISO pomalidomide binds to [SALL4 protein binds to CRBN protein]
pomalidomide results in increased degradation of and results in decreased expression of SALL4 protein
CTD PMID:30067223 NCBI chr 3:157,474,067...157,491,055
Ensembl chr 3:157,474,642...157,490,822
JBrowse link
G Spi1 Spi-1 proto-oncogene increases expression
decreases expression
ISO pomalidomide results in increased expression of SPI1 mRNA
pomalidomide results in decreased expression of SPI1 protein
CTD PMID:15292067 PMID:16373662 NCBI chr 3:77,059,744...77,093,730
Ensembl chr 3:77,073,012...77,092,393
JBrowse link
G Wiz WIZ zinc finger multiple interactions ISO pomalidomide results in increased degradation of and results in decreased expression of WIZ protein CTD PMID:30067223 NCBI chr 7:11,366,837...11,395,279
Ensembl chr 7:11,367,035...11,395,490
JBrowse link
G Zbtb39 zinc finger and BTB domain containing 39 multiple interactions ISO pomalidomide results in increased degradation of and results in decreased expression of ZBTB39 protein CTD PMID:30067223 NCBI chr 7:63,577,030...63,584,527
Ensembl chr 7:63,576,917...63,589,210
JBrowse link
G Zfp653 zinc finger protein 653 multiple interactions ISO pomalidomide results in increased degradation of and results in decreased expression of ZNF653 protein CTD PMID:30067223 NCBI chr 8:20,586,563...20,605,439
Ensembl chr 8:20,586,563...20,604,864
JBrowse link
G Zfp91 zinc finger protein 91 multiple interactions ISO pomalidomide results in increased degradation of and results in decreased expression of ZFP91 protein CTD PMID:30067223 NCBI chr 1:209,891,344...209,928,890
Ensembl chr 1:209,891,344...209,927,762
JBrowse link
pyrazine-2-carboxylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acmsd aminocarboxymuconate semialdehyde decarboxylase decreases activity EXP pyrazinoic acid metabolite results in decreased activity of ACMSD protein CTD PMID:12224625 NCBI chr13:39,200,486...39,244,337
Ensembl chr13:39,200,314...39,245,209
JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions EXP
ISO
pyrazinoic acid promotes the reaction [SLC22A12 protein affects the transport of Uric Acid] CTD PMID:14747372 PMID:21074513 NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO pyrazinoic acid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid] CTD PMID:12472777 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
JBrowse link
pyrazinecarboxamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression EXP Pyrazinamide results in increased expression of ABCA1 mRNA CTD PMID:22431067 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Abca3 ATP binding cassette subfamily A member 3 decreases expression EXP Pyrazinamide results in decreased expression of ABCA3 mRNA CTD PMID:22431067 NCBI chr10:13,382,439...13,439,748
Ensembl chr10:13,382,540...13,439,745
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression
multiple interactions
EXP Pyrazinamide results in decreased expression of ABCB11 mRNA; Pyrazinamide results in decreased expression of ABCB11 protein
obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of ABCB11 mRNA]
CTD PMID:27255380 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 multiple interactions
decreases expression
EXP obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of ABCB4 mRNA]
Pyrazinamide results in decreased expression of ABCB4 mRNA; Pyrazinamide results in decreased expression of ABCB4 protein
CTD PMID:27255380 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Abcb6 ATP binding cassette subfamily B member 6 increases expression EXP Pyrazinamide results in increased expression of ABCB6 mRNA CTD PMID:22431067 NCBI chr 9:76,668,554...76,677,263
Ensembl chr 9:76,668,554...76,676,924
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
decreases expression
EXP obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of ABCC2 mRNA]
Pyrazinamide results in decreased expression of ABCC2 mRNA; Pyrazinamide results in decreased expression of ABCC2 protein
CTD PMID:27255380 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP Pyrazinamide results in increased expression of ABCC3 mRNA; Pyrazinamide results in increased expression of ABCC3 protein CTD PMID:27255380 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcg3l1 ATP-binding cassette, subfamily G (WHITE), member 3-like 1 decreases expression EXP Pyrazinamide results in decreased expression of ABCG3L1 mRNA CTD PMID:22431067 NCBI chr14:5,124,541...5,177,265
Ensembl chr14:5,124,353...5,177,184
JBrowse link
G Acaa1a acetyl-CoA acyltransferase 1A increases expression
multiple interactions
EXP Pyrazinamide results in increased expression of ACAA1 mRNA
Fenofibrate promotes the reaction [Pyrazinamide results in increased expression of ACAA1 mRNA]; Pyrazinamide promotes the reaction [Fenofibrate results in increased expression of ACAA1 mRNA]
CTD PMID:22431067 PMID:27071702 NCBI chr 8:119,079,401...119,088,624
Ensembl chr 8:119,079,775...119,088,624
JBrowse link
G Acaa1b acetyl-Coenzyme A acyltransferase 1B increases expression EXP Pyrazinamide results in increased expression of ACAA1B mRNA CTD PMID:22431067 NCBI chr 8:118,872,996...118,881,852
Ensembl chr 8:118,872,997...118,881,825
JBrowse link
G Acsm2 acyl-CoA synthetase medium-chain family member 2 increases expression EXP Pyrazinamide results in increased expression of ACSM2 mRNA CTD PMID:22431067 NCBI chr 1:173,916,368...173,955,116
Ensembl chr 1:173,916,368...173,955,116
JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 increases expression EXP Pyrazinamide results in increased expression of AKR7A3 mRNA CTD PMID:22431067 NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP Pyrazinamide results in increased expression of ALDH1A1 mRNA CTD PMID:22431067 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 increases expression EXP Pyrazinamide results in increased expression of ALDH1L1 mRNA CTD PMID:22431067 NCBI chr 4:123,059,989...123,106,471
Ensembl chr 4:123,060,008...123,106,465
JBrowse link
G Alkbh2 alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase decreases expression EXP Pyrazinamide results in decreased expression of ALKBH2 mRNA CTD PMID:22431067 NCBI chr12:42,494,187...42,500,929
Ensembl chr12:42,496,300...42,500,914
JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions
increases expression
EXP [Fenofibrate co-treated with Pyrazinamide] results in increased expression of APOA1 mRNA
Pyrazinamide results in increased expression of APOA1 mRNA
CTD PMID:22431067 PMID:27071702 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression EXP Pyrazinamide results in increased expression of ASNS mRNA CTD PMID:22431067 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
JBrowse link
G Atf3 activating transcription factor 3 increases expression EXP Pyrazinamide results in increased expression of ATF3 mRNA CTD PMID:22431067 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
increases expression
ISO
EXP
4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of ATF4 protein]
Pyrazinamide results in increased expression of ATF4 mRNA; Pyrazinamide results in increased expression of ATF4 protein
CTD PMID:28063906 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Atf6 activating transcription factor 6 increases expression ISO Pyrazinamide results in increased expression of ATF6 mRNA CTD PMID:28063906 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
JBrowse link
G Bcl2l10 BCL2 like 10 decreases expression EXP Pyrazinamide results in decreased expression of BCL2L10 mRNA CTD PMID:22431067 NCBI chr 8:76,107,326...76,113,373
Ensembl chr 8:76,107,326...76,113,367
JBrowse link
G Bcl2l2 Bcl2-like 2 decreases expression EXP Pyrazinamide results in decreased expression of BCL2L2 mRNA CTD PMID:22431067 NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624
JBrowse link
G Bcl7c BAF chromatin remodeling complex subunit BCL7C increases expression EXP Pyrazinamide results in increased expression of BCL7C mRNA CTD PMID:22431067 NCBI chr 1:182,277,163...182,324,274
Ensembl chr 1:182,260,164...182,324,163
JBrowse link
G Bmf Bcl2 modifying factor decreases expression EXP Pyrazinamide results in decreased expression of BMF mRNA CTD PMID:22431067 NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145
JBrowse link
G Casp3 caspase 3 increases cleavage ISO Pyrazinamide results in increased cleavage of CASP3 protein CTD PMID:28063906 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccar1 cell division cycle and apoptosis regulator 1 decreases expression EXP Pyrazinamide results in decreased expression of CCAR1 mRNA CTD PMID:22431067 NCBI chr20:30,685,916...30,728,531
Ensembl chr20:30,685,916...30,728,526
JBrowse link
G Ccne2 cyclin E2 decreases expression EXP Pyrazinamide results in decreased expression of CCNE2 mRNA CTD PMID:22431067 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
JBrowse link
G Cdk20 cyclin-dependent kinase 20 decreases expression EXP Pyrazinamide results in decreased expression of CDK20 mRNA CTD PMID:22431067 NCBI chr17:701,122...707,869
Ensembl chr17:701,124...707,826
JBrowse link
G Cdk4 cyclin-dependent kinase 4 increases expression EXP Pyrazinamide results in increased expression of CDK4 mRNA CTD PMID:22431067 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdkn2d cyclin dependent kinase inhibitor 2D increases expression EXP Pyrazinamide results in increased expression of CDKN2D mRNA CTD PMID:22431067 NCBI chr 8:19,831,874...19,834,640
Ensembl chr 8:19,831,866...19,834,674
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression EXP Pyrazinamide results in increased expression of CEBPB mRNA CTD PMID:22431067 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta increases expression EXP Pyrazinamide results in increased expression of CEBPD mRNA CTD PMID:22431067 NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression EXP Pyrazinamide results in increased expression of COL1A1 mRNA CTD PMID:22431067 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B decreases expression
multiple interactions
EXP Pyrazinamide results in decreased expression of CPT1B mRNA
Fenofibrate inhibits the reaction [Pyrazinamide results in decreased expression of CPT1B mRNA]
CTD PMID:22431067 PMID:27071702 NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression EXP Pyrazinamide results in increased expression of CYP1A2 mRNA CTD PMID:22431067 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP Pyrazinamide results in increased expression of CYP2B1 mRNA CTD PMID:22431067 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP Pyrazinamide results in increased expression of CYP2B2 mRNA CTD PMID:22431067 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
JBrowse link
G Cyp2b21 cytochrome P450, family 2, subfamily b, polypeptide 21 increases expression EXP Pyrazinamide results in increased expression of CYP2B21 mRNA CTD PMID:22431067 NCBI chr 1:81,886,097...81,915,066
Ensembl chr 1:81,886,098...81,915,066
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases expression EXP Pyrazinamide results in increased expression of CYP2D4 mRNA CTD PMID:22431067 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp2d5 cytochrome P450, family 2, subfamily d, polypeptide 5 increases expression EXP Pyrazinamide results in increased expression of CYP2D5 mRNA CTD PMID:22431067 NCBI chr 7:113,899,905...113,904,458
Ensembl chr 7:113,899,890...113,904,495
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP [Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein; [Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA; [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]; [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA]; Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]; Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA] CTD PMID:27919644 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp2j3 cytochrome P450, family 2, subfamily j, polypeptide 3 decreases expression EXP Pyrazinamide results in decreased expression of CYP2J3 mRNA CTD PMID:22431067 NCBI chr 5:111,219,921...111,244,987 JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions EXP [Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA; [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA]; Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA] CTD PMID:27919644 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP Pyrazinamide results in increased expression of CYP3A23-3A1 mRNA CTD PMID:22431067 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 decreases expression EXP Pyrazinamide results in decreased expression of CYP3A9 mRNA CTD PMID:22431067 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Cyp51 cytochrome P450, family 51 increases expression EXP Pyrazinamide results in increased expression of CYP51 mRNA CTD PMID:22431067 NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases expression EXP Pyrazinamide results in increased expression of CYP7A1 mRNA; Pyrazinamide results in increased expression of CYP7A1 protein CTD PMID:27255380 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression
increases expression
EXP Pyrazinamide results in decreased expression of CYP8B1 mRNA; Pyrazinamide results in decreased expression of CYP8B1 protein
Pyrazinamide results in increased expression of CYP8B1 mRNA
CTD PMID:22431067 PMID:27255380 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
EXP
ISO
4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of DDIT3 protein]
Pyrazinamide results in increased expression of DDIT3 mRNA; Pyrazinamide results in increased expression of DDIT3 protein
CTD PMID:28063906 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Dyrk2 dual specificity tyrosine phosphorylation regulated kinase 2 decreases expression EXP Pyrazinamide results in decreased expression of DYRK2 mRNA CTD PMID:22431067 NCBI chr 7:54,348,724...54,381,363
Ensembl chr 7:54,349,610...54,380,106
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases phosphorylation
ISO
EXP
4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased phosphorylation of EIF2AK3 protein] CTD PMID:28063906 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation
multiple interactions
ISO
EXP
Pyrazinamide results in increased phosphorylation of EIF2S1 protein
4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased phosphorylation of EIF2S1 protein]
CTD PMID:28063906 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Ep300 E1A binding protein p300 decreases expression EXP Pyrazinamide results in decreased expression of EP300 mRNA CTD PMID:22431067 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression EXP Pyrazinamide results in increased expression of EPHX1 mRNA CTD PMID:22431067 NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235
JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit increases expression EXP Pyrazinamide results in increased expression of ERCC1 mRNA CTD PMID:22431067 NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases expression ISO Pyrazinamide results in increased expression of ERN1 mRNA CTD PMID:28063906 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Fabp1 fatty acid binding protein 1 multiple interactions
decreases expression
EXP Fenofibrate inhibits the reaction [Pyrazinamide results in decreased expression of FABP1 mRNA] CTD PMID:27071702 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
JBrowse link
G Fabp7 fatty acid binding protein 7 decreases expression EXP Pyrazinamide results in decreased expression of FABP7 mRNA CTD PMID:22431067 NCBI chr20:37,123,193...37,126,725
Ensembl chr20:37,123,193...37,126,880
JBrowse link
G Fbxw11 F-box and WD repeat domain containing 11 decreases expression EXP Pyrazinamide results in decreased expression of FBXW11 mRNA CTD PMID:22431067 NCBI chr10:17,232,735...17,330,584
Ensembl chr10:17,227,181...17,330,571
JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 increases expression EXP Pyrazinamide results in increased expression of FMO1 mRNA CTD PMID:22431067 NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression EXP Pyrazinamide results in increased expression of GADD45A mRNA CTD PMID:22431067 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gas2 growth arrest-specific 2 increases expression EXP Pyrazinamide results in increased expression of GAS2 mRNA CTD PMID:22431067 NCBI chr 1:101,452,361...101,582,619
Ensembl chr 1:101,482,591...101,582,619
JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression
multiple interactions
EXP Pyrazinamide results in increased expression of GPT protein
4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of GPT protein]; Fenofibrate inhibits the reaction [Pyrazinamide results in increased expression of GPT protein]
CTD PMID:27071702 PMID:28063906 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gsta4 glutathione S-transferase alpha 4 increases expression EXP Pyrazinamide results in increased expression of GSTA4 mRNA CTD PMID:22431067 NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases expression EXP Pyrazinamide results in increased expression of GSTA5 mRNA CTD PMID:22431067 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression EXP Pyrazinamide results in increased expression of GSTM1 mRNA CTD PMID:22431067 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Gstm2 glutathione S-transferase mu 2 increases expression EXP Pyrazinamide results in increased expression of GSTM2 mRNA CTD PMID:22431067 NCBI chr 2:195,624,015...195,628,774 JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression EXP Pyrazinamide results in increased expression of GSTP1 mRNA CTD PMID:22431067 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Gstt1 glutathione S-transferase theta 1 multiple interactions ISO GSTT1 gene polymorphism results in increased susceptibility to [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide] CTD PMID:18397238 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression EXP Pyrazinamide results in increased expression of HMGCS1 mRNA CTD PMID:22431067 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 increases expression EXP Pyrazinamide results in increased expression of HMGCS2 mRNA CTD PMID:22431067 NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP Pyrazinamide results in increased expression of HMOX1 mRNA CTD PMID:22431067 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 increases expression EXP Pyrazinamide results in increased expression of HSD11B1 mRNA CTD PMID:22431067 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression
EXP
ISO
4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of HSPA5 protein]
Pyrazinamide results in increased expression of HSPA5 mRNA; Pyrazinamide results in increased expression of HSPA5 protein
CTD PMID:28063906 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 decreases expression EXP Pyrazinamide results in decreased expression of ITPR1 mRNA CTD PMID:22431067 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491
JBrowse link
G Lpl lipoprotein lipase decreases expression
multiple interactions
EXP Pyrazinamide results in decreased expression of LPL mRNA
Fenofibrate inhibits the reaction [Pyrazinamide results in decreased expression of LPL mRNA]
CTD PMID:27071702 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Me1 malic enzyme 1 increases expression EXP Pyrazinamide results in increased expression of ME1 mRNA CTD PMID:22431067 PMID:27071702 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
JBrowse link
G Mgst3 microsomal glutathione S-transferase 3 increases expression EXP Pyrazinamide results in increased expression of MGST3 mRNA CTD PMID:22431067 NCBI chr13:79,526,541...79,547,479
Ensembl chr13:79,526,541...79,547,411
JBrowse link
G Mixl1 Mix paired-like homeobox 1 decreases expression EXP Pyrazinamide results in decreased expression of MIXL1 mRNA CTD PMID:22431067 NCBI chr13:92,422,031...92,426,065
Ensembl chr13:92,422,031...92,426,065
JBrowse link
G Mrps14 mitochondrial ribosomal protein S14 decreases expression EXP Pyrazinamide results in decreased expression of MRPS14 mRNA CTD PMID:22431067 NCBI chr13:72,429,168...72,434,915
Ensembl chr13:72,408,558...72,434,915
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions
decreases expression
EXP obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of NR0B2 mRNA] CTD PMID:27255380 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
decreases expression
EXP obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of NR1H4 mRNA]
Pyrazinamide results in decreased expression of NR1H4 mRNA; Pyrazinamide results in decreased expression of NR1H4 protein
CTD PMID:27255380 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Nsdhl NAD(P) dependent steroid dehydrogenase-like increases expression EXP Pyrazinamide results in increased expression of NSDHL mRNA CTD PMID:22431067 NCBI chr  X:150,775,034...150,807,161
Ensembl chr  X:150,775,080...150,807,142
JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 decreases expression EXP Pyrazinamide results in decreased expression of NTRK1 mRNA CTD PMID:22431067 NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770
JBrowse link
G Perp p53 apoptosis effector related to PMP22 increases expression EXP Pyrazinamide results in increased expression of PERP mRNA CTD PMID:22431067 NCBI chr 1:13,542,067...13,554,514
Ensembl chr 1:13,542,067...13,554,511
JBrowse link
G Phgdh phosphoglycerate dehydrogenase increases expression EXP Pyrazinamide results in increased expression of PHGDH mRNA CTD PMID:22431067 NCBI chr 2:185,906,964...185,936,160
Ensembl chr 2:185,906,966...185,935,944
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
decreases expression
ISO
EXP
[Pyrazinamide co-treated with Glucose] binds to PPARA protein; Pyrazinamide inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]
Fenofibrate inhibits the reaction [Pyrazinamide results in decreased expression of PPARA mRNA]
Pyrazinamide results in decreased expression of PPARA mRNA; Pyrazinamide results in decreased expression of PPARA protein
CTD PMID:18812576 PMID:27071702 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha increases expression EXP Pyrazinamide results in increased expression of PPP2R1A mRNA CTD PMID:22431067 NCBI chr 1:60,540,223...60,559,467
Ensembl chr 1:60,540,194...60,560,129
JBrowse link
G Prom1 prominin 1 decreases expression EXP Pyrazinamide results in decreased expression of PROM1 mRNA CTD PMID:22431067 NCBI chr14:66,989,545...67,094,534
Ensembl chr14:66,990,160...67,094,527
JBrowse link
G Slc10a1 solute carrier family 10 member 1 increases expression EXP Pyrazinamide results in increased expression of SLC10A1 mRNA; Pyrazinamide results in increased expression of SLC10A1 protein CTD PMID:27255380 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
JBrowse link
G Slc16a11 solute carrier family 16, member 11 decreases expression EXP Pyrazinamide results in decreased expression of SLC16A11 mRNA CTD PMID:22431067 NCBI chr10:54,929,129...54,933,021
Ensembl chr10:54,927,725...54,942,915
JBrowse link
G Slc17a1 solute carrier family 17 member 1 increases expression EXP Pyrazinamide results in increased expression of SLC17A1 mRNA CTD PMID:22431067 NCBI chr17:41,219,461...41,255,199 JBrowse link
G Slc22a12 solute carrier family 22 member 12 affects activity ISO Pyrazinamide affects the activity of SLC22A12 protein CTD PMID:14694169 NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555
JBrowse link
G Slc22a13l1 solute carrier family 22 member 13-like 1 decreases expression EXP Pyrazinamide results in decreased expression of SLC22A13 mRNA CTD PMID:22431067 NCBI chr 8:118,958,209...118,972,614
Ensembl chr 8:118,961,000...118,966,046
JBrowse link
G Slc25a39 solute carrier family 25, member 39 increases expression EXP Pyrazinamide results in increased expression of SLC25A39 mRNA CTD PMID:22431067 NCBI chr10:87,362,494...87,367,358
Ensembl chr10:87,362,490...87,367,260
JBrowse link
G Slc25a4 solute carrier family 25 member 4 decreases expression EXP Pyrazinamide results in decreased expression of SLC25A4 mRNA CTD PMID:22431067 NCBI chr16:46,072,935...46,076,730
Ensembl chr16:46,072,939...46,076,733
JBrowse link
G Slc25a42 solute carrier family 25, member 42 decreases expression EXP Pyrazinamide results in decreased expression of SLC25A42 mRNA CTD PMID:22431067 NCBI chr16:19,213,914...19,251,990
Ensembl chr16:19,213,950...19,237,025
JBrowse link
G Slc29a1 solute carrier family 29 member 1 decreases expression EXP Pyrazinamide results in decreased expression of SLC29A1 mRNA CTD PMID:22431067 NCBI chr 9:15,399,661...15,414,203
Ensembl chr 9:15,399,612...15,414,203
JBrowse link
G Slc51a solute carrier family 51 subunit alpha decreases expression EXP Pyrazinamide results in decreased expression of SLC51A mRNA; Pyrazinamide results in decreased expression of SLC51A protein CTD PMID:27255380 NCBI chr11:68,299,086...68,313,485
Ensembl chr11:68,299,086...68,313,485
JBrowse link
G Slc51b solute carrier family 51 subunit beta multiple interactions
decreases expression
EXP obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of SLC51B mRNA]
Pyrazinamide results in decreased expression of SLC51B mRNA; Pyrazinamide results in decreased expression of SLC51B protein
CTD PMID:27255380 NCBI chr 8:65,931,891...65,934,893
Ensembl chr 8:65,931,890...65,940,145
JBrowse link
G Slc6a9 solute carrier family 6 member 9 decreases expression EXP Pyrazinamide results in decreased expression of SLC6A9 mRNA CTD PMID:22431067 NCBI chr 5:131,374,562...131,408,733
Ensembl chr 5:131,374,542...131,408,728
JBrowse link
G Slc7a10 solute carrier family 7 member 10 decreases expression EXP Pyrazinamide results in decreased expression of SLC7A10 mRNA CTD PMID:22431067 NCBI chr 1:87,829,084...87,845,073
Ensembl chr 1:87,829,175...87,845,071
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 increases expression EXP Pyrazinamide results in increased expression of SLCO1A4 mRNA; Pyrazinamide results in increased expression of SLCO1A4 protein CTD PMID:27255380 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 decreases expression
multiple interactions
EXP Pyrazinamide results in decreased expression of SLCO1B2 mRNA; Pyrazinamide results in decreased expression of SLCO1B2 protein
obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of SLCO1B2 mRNA]
CTD PMID:27255380 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
JBrowse link
G Slco4a1 solute carrier organic anion transporter family, member 4a1 decreases expression EXP Pyrazinamide results in decreased expression of SLCO4A1 mRNA CTD PMID:22431067 NCBI chr 3:167,559,177...167,578,307
Ensembl chr 3:167,559,316...167,578,305
JBrowse link
G Srm spermidine synthase increases expression EXP Pyrazinamide results in increased expression of SRM mRNA CTD PMID:22431067 NCBI chr 5:159,025,919...159,029,076
Ensembl chr 5:159,025,873...159,029,405
JBrowse link
G Sult1c2a sulfotransferase family, cytosolic, 1C, member 2a decreases expression EXP Pyrazinamide results in decreased expression of SULT1C2A mRNA CTD PMID:22431067 NCBI chr 9:6,873,697...6,904,736
Ensembl chr 9:6,874,249...6,904,734
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 decreases expression EXP Pyrazinamide results in decreased expression of SULT2A1 mRNA CTD PMID:22431067 NCBI chr 1:75,451,178...75,508,142 JBrowse link
G Ticrr TOPBP1-interacting checkpoint and replication regulator decreases expression EXP Pyrazinamide results in decreased expression of TICRR mRNA CTD PMID:22431067 NCBI chr 1:133,597,618...133,639,513
Ensembl chr 1:133,597,716...133,639,523
JBrowse link
G Tmem176a transmembrane protein 176A increases expression EXP Pyrazinamide results in increased expression of TMEM176A mRNA CTD PMID:22431067 NCBI chr 4:77,774,940...77,778,620
Ensembl chr 4:77,774,843...77,778,620
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases expression EXP Pyrazinamide results in increased expression of UGT1A2 mRNA CTD PMID:22431067 NCBI chr 9:88,791,216...88,808,465 JBrowse link
G Vdac1 voltage-dependent anion channel 1 increases expression EXP Pyrazinamide results in increased expression of VDAC1 mRNA CTD PMID:22431067 NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640
JBrowse link
G Xbp1 X-box binding protein 1 increases expression ISO Pyrazinamide results in increased expression of XBP1 mRNA alternative form CTD PMID:28063906 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
JBrowse link
G Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta increases expression EXP Pyrazinamide results in increased expression of YWHAH mRNA CTD PMID:22431067 NCBI chr14:77,696,332...77,705,715
Ensembl chr14:77,696,333...77,705,741
JBrowse link
rifabutin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadac arylacetamide deacetylase multiple interactions
decreases acetylation
ISO AADAC mRNA affects the reaction [Rifabutin results in increased expression of CYP3A4 mRNA]; bis(4-nitrophenyl)phosphate inhibits the reaction [AADAC protein results in decreased acetylation of Rifabutin]; Isoflurophate inhibits the reaction [AADAC protein results in decreased acetylation of Rifabutin]; Phenylmethylsulfonyl Fluoride inhibits the reaction [AADAC protein results in decreased acetylation of Rifabutin]; Physostigmine inhibits the reaction [AADAC protein results in decreased acetylation of Rifabutin]; Sodium Fluoride inhibits the reaction [AADAC protein results in decreased acetylation of Rifabutin] CTD PMID:21856291 NCBI chr 2:144,163,436...144,186,086
Ensembl chr 2:144,135,319...144,174,734
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Rifabutin results in decreased activity of ABCB11 protein CTD PMID:20829430 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
multiple interactions
ISO Rifabutin results in increased expression of CYP3A4 mRNA
AADAC mRNA affects the reaction [Rifabutin results in increased expression of CYP3A4 mRNA]
CTD PMID:16837568 PMID:21856291 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
rifampicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadac arylacetamide deacetylase multiple interactions
increases hydrolysis
decreases acetylation
ISO AADAC mRNA affects the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; bis(4-nitrophenyl)phosphate inhibits the reaction [AADAC protein results in decreased acetylation of Rifampin]; Isoflurophate inhibits the reaction [AADAC protein results in decreased acetylation of Rifampin]; Phenylmethylsulfonyl Fluoride inhibits the reaction [AADAC protein results in decreased acetylation of Rifampin]; Physostigmine inhibits the reaction [AADAC protein results in decreased acetylation of Rifampin]; Sodium Fluoride inhibits the reaction [AADAC protein results in decreased acetylation of Rifampin]
AADAC protein results in increased hydrolysis of Rifampin
CTD PMID:21856291 PMID:22207054 NCBI chr 2:144,163,436...144,186,086
Ensembl chr 2:144,135,319...144,174,734
JBrowse link
G Abca1 ATP binding cassette subfamily A member 1 decreases expression
increases expression
ISO Rifampin results in decreased expression of ABCA1 mRNA; Rifampin results in decreased expression of ABCA1 protein
Rifampin results in increased expression of ABCA1 mRNA; Rifampin results in increased expression of ABCA1 protein
CTD PMID:15883047 PMID:17088262 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Abca2 ATP binding cassette subfamily A member 2 increases expression ISO Rifampin results in increased expression of ABCA2 mRNA CTD PMID:27199754 NCBI chr 3:8,244,515...8,264,545
Ensembl chr 3:8,244,639...8,264,537
JBrowse link
G Abca8 ATP binding cassette subfamily A member 8 decreases expression ISO Rifampin results in decreased expression of ABCA8 mRNA CTD PMID:27199754 NCBI chr10:94,917,520...94,991,199
Ensembl chr10:94,917,520...94,990,988
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression
decreases activity
multiple interactions
ISO
EXP
Rifampin results in decreased expression of ABCB11 mRNA
Rifampin results in decreased activity of ABCB11 protein
Rifampin inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
CTD PMID:12135489 PMID:16837569 PMID:20829430 PMID:24014644 PMID:28437613 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression
decreases activity
affects activity
ISO
EXP
[NR1I2 protein results in increased susceptibility to Rifampin] which results in increased expression of ABCB1 mRNA; [NR1I2 protein results in increased susceptibility to Rifampin] which results in increased expression of ABCB1 protein; [Rifampin binds to and results in increased activity of NR1I2 protein] promotes the reaction [ABCB1 protein results in decreased uptake of Doxorubicin]; [Rifampin results in increased activity of NR1I2 protein] which results in increased expression of ABCB1 protein; Camptothecin inhibits the reaction [Rifampin results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of ABCB1 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of ABCB1 protein]]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of ABCB1 protein]; mulberroside A inhibits the reaction [[NR1I2 protein results in increased susceptibility to Rifampin] which results in increased expression of ABCB1 mRNA]; mulberroside A inhibits the reaction [[NR1I2 protein results in increased susceptibility to Rifampin] which results in increased expression of ABCB1 protein]; NR1I2 protein promotes the reaction [Rifampin results in increased expression of ABCB1 mRNA]; NR1I2 protein promotes the reaction [Rifampin results in increased expression of ABCB1 protein]; pimecrolimus inhibits the reaction [Rifampin results in increased expression of ABCB1 mRNA]; Resveratrol inhibits the reaction [Rifampin results in increased expression of ABCB1 protein]; Rifampin promotes the reaction [ABCB1 protein results in increased transport of Digoxin]; Rifampin promotes the reaction [NR1I2 protein binds to ABCB1 promoter]
Rifampin results in increased expression of ABCB1 mRNA; Rifampin results in increased expression of ABCB1 protein
[Rifampin metabolite results in decreased activity of ABCB1A protein] which results in decreased abundance of Adenosine Triphosphate
Rifampin affects the activity of ABCB1 protein
CTD PMID:8632764 PMID:11744607 PMID:14722322 PMID:15276086 PMID:15290871 More... NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 increases expression ISO Rifampin results in increased expression of ABCB4 mRNA CTD PMID:27199754 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Abcb6 ATP binding cassette subfamily B member 6 increases expression ISO Rifampin results in increased expression of ABCB6 mRNA CTD PMID:27199754 NCBI chr 9:76,668,554...76,677,263
Ensembl chr 9:76,668,554...76,676,924
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression ISO Rifampin results in increased expression of ABCC1 mRNA CTD PMID:17191263 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc10 ATP binding cassette subfamily C member 10 increases expression ISO Rifampin results in increased expression of ABCC10 mRNA CTD PMID:27199754 NCBI chr 9:14,657,242...14,677,178
Ensembl chr 9:14,657,264...14,677,178
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects export
increases expression
multiple interactions
ISO ABCC2 protein affects the export of Rifampin
Rifampin results in increased expression of ABCC2; Rifampin results in increased expression of ABCC2 mRNA; Rifampin results in increased expression of ABCC2 protein
[Rifampin co-treated with ABCC2 gene mutant form] results in increased expression of ABCC3 protein
CTD PMID:11836020 PMID:12206135 PMID:15652233 PMID:16837569 PMID:16952291 More... NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions
increases expression
increases activity
ISO [Rifampin co-treated with ABCC2 gene mutant form] results in increased expression of ABCC3 protein; [Rifampin results in increased activity of NR1I2 protein] which results in increased expression of ABCC3 mRNA; Rifampin inhibits the reaction [Decitabine results in increased expression of ABCC3 mRNA]
Rifampin results in increased expression of ABCC3 mRNA
Rifampin results in increased activity of ABCC3 protein
CTD PMID:14570758 PMID:16837569 PMID:16952291 PMID:19041851 PMID:20832446 More... NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 increases expression ISO Rifampin results in increased expression of ABCC5 mRNA CTD PMID:19041851 NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253
JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 increases expression ISO Rifampin results in increased expression of ABCC6 mRNA CTD PMID:27199754 NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464
JBrowse link
G Abcf1 ATP binding cassette subfamily F member 1 increases expression ISO Rifampin results in increased expression of ABCF1 mRNA CTD PMID:27199754 NCBI chr20:2,802,519...2,815,433
Ensembl chr20:2,802,488...2,815,433
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 increases expression ISO Rifampin results in increased expression of ABCG1 mRNA; Rifampin results in increased expression of ABCG1 protein CTD PMID:12040753 PMID:17088262 NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases expression ISO Rifampin results in increased expression of ABCG2 mRNA CTD PMID:16837569 PMID:27199754 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 increases expression ISO Rifampin results in increased expression of ABCG8 mRNA CTD PMID:27199754 NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912
JBrowse link
G Abi3 ABI family, member 3 decreases expression ISO Rifampin results in decreased expression of ABI3 mRNA CTD PMID:24552687 NCBI chr10:80,769,819...80,780,816
Ensembl chr10:80,769,822...80,780,816
JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases expression ISO Rifampin results in increased expression of ACACA mRNA CTD PMID:27806127 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Ace2 angiotensin I converting enzyme 2 decreases expression ISO Rifampin results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Actr10 actin related protein 10 increases expression ISO Rifampin results in increased expression of ACTR10 mRNA CTD PMID:24552687 NCBI chr 6:89,446,141...89,472,350
Ensembl chr 6:89,446,093...89,473,047
JBrowse link
G Adh1 alcohol dehydrogenase 1 (class I) increases expression ISO Rifampin results in increased expression of ADH1C mRNA CTD PMID:12040753 NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892
JBrowse link
G Adora2a adenosine A2a receptor decreases expression ISO Rifampin results in decreased expression of ADORA2A mRNA CTD PMID:24552687 NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
JBrowse link
G Agap2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 decreases expression ISO Rifampin results in decreased expression of AGAP2 mRNA CTD PMID:24552687 NCBI chr 7:62,897,282...62,914,295
Ensembl chr 7:62,897,282...62,914,295
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases expression
ISO [Rifampin co-treated with Benzo(a)pyrene] results in increased expression of AHR mRNA; [Rifampin co-treated with Monocrotophos] results in decreased expression of AHR mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of AHR protein; NR1I2 protein inhibits the reaction [[Rifampin co-treated with Benzo(a)pyrene] results in increased expression of AHR mRNA]
Rifampin results in increased expression of AHR mRNA; Rifampin results in increased expression of AHR protein
CTD PMID:22733800 PMID:28428138 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression
multiple interactions
ISO Rifampin results in increased expression of AKR1B10 mRNA
pazopanib inhibits the reaction [Rifampin results in increased expression of AKR1B10 mRNA]; pimecrolimus inhibits the reaction [Rifampin results in increased expression of AKR1B10 mRNA]
CTD PMID:29356861 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
JBrowse link
G Alas1 5'-aminolevulinate synthase 1 increases expression ISO Rifampin results in increased expression of ALAS1 mRNA CTD PMID:24259679 PMID:24552687 NCBI chr 8:106,876,514...106,889,852
Ensembl chr 8:106,876,514...106,889,917
JBrowse link
G Angptl3 angiopoietin-like 3 decreases expression ISO Rifampin results in decreased expression of ANGPTL3 mRNA CTD PMID:32535746 NCBI chr 5:113,703,007...113,710,044
Ensembl chr 5:113,703,012...113,709,957
JBrowse link
G Angptl4 angiopoietin-like 4 multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of ANGPTL4 mRNA CTD PMID:21127053 NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519
JBrowse link
G Ankrd65 ankyrin repeat domain 65 decreases expression ISO Rifampin results in decreased expression of ANKRD65 mRNA CTD PMID:24552687 NCBI chr 5:166,398,359...166,400,616
Ensembl chr 5:166,397,748...166,400,953
JBrowse link
G Anks1b ankyrin repeat and sterile alpha motif domain containing 1B decreases expression ISO Rifampin results in decreased expression of ANKS1B mRNA CTD PMID:24552687 NCBI chr 7:24,313,810...25,479,307
Ensembl chr 7:24,312,843...25,477,693
JBrowse link
G Anxa5 annexin A5 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of ANXA5 mRNA CTD PMID:21224054 NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369
JBrowse link
G Apob apolipoprotein B decreases expression
multiple interactions
affects secretion
ISO Rifampin results in decreased expression of APOB mRNA
ursodoxicoltaurine inhibits the reaction [Rifampin results in decreased expression of APOB mRNA]
Rifampin affects the secretion of APOB protein
CTD PMID:32535746 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
JBrowse link
G Apoc3 apolipoprotein C3 decreases expression
decreases secretion
ISO Rifampin results in decreased expression of APOC3 mRNA
Rifampin results in decreased secretion of APOC3 protein
CTD PMID:32535746 NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583
JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of AQP3 mRNA CTD PMID:21127053 NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720
JBrowse link
G Aqp4 aquaporin 4 decreases expression ISO Rifampin results in decreased expression of AQP4 mRNA CTD PMID:24552687 NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856
JBrowse link
G Arsj arylsulfatase family, member J decreases expression ISO Rifampin results in decreased expression of ARSJ mRNA CTD PMID:24552687 NCBI chr 2:214,775,483...214,853,655 JBrowse link
G Atf3 activating transcription factor 3 multiple interactions ISO [Rifampin co-treated with Cobicistat] results in increased expression of ATF3 mRNA CTD PMID:33629115 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
increases expression
EXP
ISO
ATF4 mutant form inhibits the reaction [Rifampin results in increased expression of HSPA5 protein]
Rifampin results in increased expression of ATF4 mRNA; Rifampin results in increased expression of ATF4 protein
4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of ATF4 mRNA]; 4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of ATF4 protein]
CTD PMID:24638036 PMID:27470132 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Atf6 activating transcription factor 6 increases expression ISO Rifampin results in increased expression of ATF6 mRNA CTD PMID:32535746 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
JBrowse link
G Atm ATM serine/threonine kinase multiple interactions
decreases expression
ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM protein
Rifampin results in decreased expression of ATM mRNA
CTD PMID:21224054 PMID:24552687 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Atp6v0a1 ATPase H+ transporting V0 subunit a1 increases expression
multiple interactions
ISO Rifampin results in increased expression of ATP6V0A1 protein
[Rotenone co-treated with Rifampin] results in increased expression of ATP6V0A1 protein; Rifampin inhibits the reaction [Rotenone results in decreased expression of ATP6V0A1 mRNA]; Rotenone inhibits the reaction [Rifampin results in increased expression of ATP6V0A1 protein]
CTD PMID:31648047 NCBI chr10:85,935,802...85,989,901
Ensembl chr10:85,935,854...85,989,895
JBrowse link
G Atp6v0d1 ATPase H+ transporting V0 subunit D1 multiple interactions ISO ATP6V0D1 protein affects the reaction [Rifampin inhibits the reaction [Rotenone results in increased lipidation of MAP1LC3B protein]] CTD PMID:31648047 NCBI chr19:33,403,352...33,447,357
Ensembl chr19:33,403,355...33,447,450
JBrowse link
G Atrx ATRX, chromatin remodeler increases expression ISO Rifampin results in increased expression of ATRX mRNA CTD PMID:24552687 NCBI chr  X:70,850,981...70,997,330
Ensembl chr  X:70,850,981...70,997,330
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
decreases expression
ISO [Isoniazid co-treated with Rifampin] results in increased expression of BAX protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of BAX mRNA; [Rifampin co-treated with Cobicistat] results in increased expression of BAX mRNA; Ursodeoxycholic Acid inhibits the reaction [[Isoniazid co-treated with Rifampin] results in increased expression of BAX protein]
[Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in increased expression of BAX protein
Rifampin results in decreased expression of BAX protein
CTD PMID:11958592 PMID:12645856 PMID:21224054 PMID:21419764 PMID:31629065 More... NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions
ISO Rifampin results in increased expression of BCL2 protein
[Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of BCL2 protein
[Isoniazid co-treated with Rifampin] results in decreased expression of BCL2 protein; Ursodeoxycholic Acid inhibits the reaction [[Isoniazid co-treated with Rifampin] results in decreased expression of BCL2 protein]
CTD PMID:11958592 PMID:21419764 PMID:31629065 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression
multiple interactions
ISO Rifampin results in increased expression of BCL2L1 protein
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of BCL2L1 mRNA
CTD PMID:11958592 PMID:12645856 PMID:21224054 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bhlhe40 basic helix-loop-helix family, member e40 multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of BHLHE40 mRNA CTD PMID:21127053 NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774
JBrowse link
G Bmp4 bone morphogenetic protein 4 multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of BMP4 mRNA CTD PMID:21127053 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
JBrowse link
G Car1 carbonic anhydrase 1 decreases expression ISO Rifampin results in decreased expression of CA1 mRNA CTD PMID:24552687 NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
JBrowse link
G Casp1 caspase 1 multiple interactions ISO Rifampin inhibits the reaction [Rotenone results in increased cleavage of CASP1 protein] CTD PMID:26086368 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Mifepristone inhibits the reaction [Rifampin inhibits the reaction [FAS protein results in increased activity of CASP3 protein]]; Rifampin inhibits the reaction [[Acetaminophen co-treated with [ferric nitrate results in increased abundance of Iron]] results in increased cleavage of CASP3 protein]; Rifampin inhibits the reaction [Doxorubicin results in increased cleavage of CASP3 protein]; Rifampin inhibits the reaction [FAS protein results in increased activity of CASP3 protein]; Rifampin inhibits the reaction [Staurosporine results in increased cleavage of CASP3 protein]; Rifampin promotes the reaction [Galactosamine results in increased activity of CASP3 protein]
[Isoniazid co-treated with Rifampin] results in increased activity of CASP3 protein; HGF protein inhibits the reaction [[Isoniazid co-treated with Rifampin] results in increased activity of CASP3 protein]; Ursodeoxycholic Acid inhibits the reaction [[Isoniazid co-treated with Rifampin] results in increased activity of CASP3 protein]
CTD PMID:11958592 PMID:12645856 PMID:17936189 PMID:21419764 PMID:23764483 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions ISO Mifepristone inhibits the reaction [Rifampin inhibits the reaction [FAS protein results in increased activity of CASP8 protein]]; Rifampin inhibits the reaction [FAS protein results in increased activity of CASP8 protein] CTD PMID:11958592 PMID:12645856 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Cbr3 carbonyl reductase 3 multiple interactions ISO [Rifampin co-treated with Cobicistat] results in increased expression of CBR3 mRNA CTD PMID:33629115 NCBI chr11:33,008,615...33,016,877
Ensembl chr11:33,008,615...33,016,875
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression EXP Rifampin results in decreased expression of CCL2 mRNA CTD PMID:25051504 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression EXP Rifampin results in decreased expression of CCL5 protein CTD PMID:25051504 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccn1 cellular communication network factor 1 multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of CCN1 mRNA CTD PMID:21127053 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CCND1 mRNA CTD PMID:21224054 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccng1 cyclin G1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CCNG1 mRNA CTD PMID:21224054 NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641
JBrowse link
G Ccr6 C-C motif chemokine receptor 6 multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of CCR6 mRNA CTD PMID:21127053 NCBI chr 1:52,474,477...52,508,301
Ensembl chr 1:52,474,168...52,498,603
JBrowse link
G Ccr7 C-C motif chemokine receptor 7 multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of CCR7 mRNA CTD PMID:21127053 NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309
JBrowse link
G Cd36 CD36 molecule increases expression ISO Rifampin results in increased expression of CD36 mRNA CTD PMID:27806127 NCBI chr 4:17,317,343...17,410,084 JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CDKN1A mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CDKN1A protein CTD PMID:21224054 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of CDKN2B mRNA CTD PMID:21127053 NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050
JBrowse link
G Ces1d carboxylesterase 1D increases expression ISO Rifampin results in increased expression of CES1 protein CTD PMID:10640517 NCBI chr19:13,873,490...13,912,035 JBrowse link
G Ces2h carboxylesterase 2H increases expression
multiple interactions
ISO Rifampin results in increased expression of CES2 mRNA; Rifampin results in increased expression of CES2 protein
Dichlororibofuranosylbenzimidazole inhibits the reaction [Rifampin results in increased expression of CES2 mRNA]; NR1I2 protein promotes the reaction [Rifampin results in increased expression of CES2 mRNA]
CTD PMID:10640517 PMID:17003103 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions
increases expression
ISO Mifepristone inhibits the reaction [Rifampin inhibits the reaction [FAS protein results in increased expression of CFLAR protein modified form]]; Rifampin inhibits the reaction [FAS protein results in increased expression of CFLAR protein modified form]
Rifampin results in increased expression of CFLAR protein
CTD PMID:11958592 PMID:12645856 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CHEK2 mRNA CTD PMID:21224054 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
JBrowse link
G Ciz1 CDKN1A interacting zinc finger protein 1 decreases expression ISO Rifampin results in decreased expression of CIZ1 mRNA CTD PMID:24552687 NCBI chr 3:15,658,479...15,675,716
Ensembl chr 3:15,658,539...15,673,762
JBrowse link
G Clk2 CDC-like kinase 2 decreases expression ISO Rifampin results in decreased expression of CLK2 mRNA CTD PMID:24552687 NCBI chr 2:174,570,614...174,582,645 JBrowse link
G Cntln centlein increases expression ISO Rifampin results in increased expression of CNTLN mRNA CTD PMID:24552687 NCBI chr 5:99,295,865...99,576,402
Ensembl chr 5:99,296,000...99,576,396
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression ISO Rifampin results in increased expression of CPT1A mRNA CTD PMID:27806127 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 decreases expression ISO Rifampin results in decreased expression of CRHR1 mRNA CTD PMID:24552687 NCBI chr10:89,040,203...89,083,481
Ensembl chr10:89,040,203...89,083,481
JBrowse link
G Crp C-reactive protein multiple interactions ISO [Floxacillin co-treated with Gentamicins co-treated with Rifampin] results in increased expression of CRP protein CTD PMID:16943303 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Csnk1g1 casein kinase 1, gamma 1 decreases expression ISO Rifampin results in decreased expression of CSNK1G1 mRNA CTD PMID:24552687 NCBI chr 8:66,439,760...66,577,247
Ensembl chr 8:66,439,864...66,572,826
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression EXP Rifampin results in increased expression of CXCL1 protein CTD PMID:25051504 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions
affects expression
ISO
EXP
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CXCL10 mRNA
Rifampin affects the expression of CXCL10 protein
CTD PMID:21224054 PMID:25051504 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cyb5rl cytochrome b5 reductase-like increases expression ISO Rifampin results in increased expression of CYB5RL mRNA CTD PMID:24552687 NCBI chr 5:121,846,223...121,868,287
Ensembl chr 5:121,847,952...121,868,745
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases activity
increases expression
EXP
ISO
Rifampin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
Rifampin results in increased activity of CYP1A1 protein
Rifampin results in increased expression of CYP1A1 mRNA; Rifampin results in increased expression of CYP1A1 protein
[Methylcholanthrene co-treated with Rifampin co-treated with Phenobarbital] results in increased expression of CYP1A1 mRNA; [Rifampin co-treated with Monocrotophos] results in increased activity of CYP1A1 protein; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP1A1 mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP1A1 protein; [Tetrachlorodibenzodioxin co-treated with Rifampin] results in increased expression of CYP1A1 mRNA; Rifampin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
CTD PMID:12040753 PMID:18493746 PMID:19118567 PMID:19409404 PMID:22733800 More... NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases expression
ISO
EXP
[Tetrachlorodibenzodioxin co-treated with Rifampin] results in increased expression of CYP1A2 mRNA; Rifampin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]
Rifampin results in increased expression of CYP1A2 mRNA
[[NR1I3 protein co-treated with NR1I2 protein] results in increased susceptibility to Rifampin] which results in decreased expression of CYP1A2 protein
Rifampin results in increased expression of CYP1A2 mRNA; Rifampin results in increased expression of CYP1A2 protein
CTD PMID:15977188 PMID:17590308 PMID:18493746 PMID:25835148 PMID:29162470 More... NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP1B1 mRNA
[Tetrachlorodibenzodioxin co-treated with Rifampin] results in increased expression of CYP1B1 mRNA
CTD PMID:21224054 PMID:29162470 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 multiple interactions
increases expression
increases activity
ISO NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP24A1 mRNA]; Rifampin promotes the reaction [NR1I2 protein binds to CYP24A1 promoter]
Rifampin results in increased activity of CYP24A1 protein
CTD PMID:15630458 PMID:21127053 NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383
JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of CYP26A1 mRNA CTD PMID:21127053 NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO Rifampin promotes the reaction [[NR1I2 protein binds to NCOA1 protein] which binds to CYP27A1 gene]
Rifampin results in increased expression of CYP27A1 mRNA
CTD PMID:17088262 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 increases expression
decreases expression
EXP
ISO
Rifampin results in increased expression of CYP2A1 mRNA
Rifampin results in increased expression of CYP2A13 mRNA
Rifampin results in decreased expression of CYP2A13 mRNA
CTD PMID:19118567 PMID:22258563 NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 multiple interactions
increases expression
increases activity
ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP2A5 mRNA
Rifampin results in increased expression of CYP2A5 mRNA
Rifampin results in increased activity of CYP2A5 protein
CTD PMID:11038160 PMID:21224054 PMID:30503582 NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions
increases expression
ISO [[NR1I3 protein co-treated with NR1I2 protein] results in increased susceptibility to Rifampin] which results in increased expression of CYP2B10 protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP2B10 mRNA
Rifampin results in increased expression of CYP2B10 mRNA
CTD PMID:21224054 PMID:25835148 PMID:30503582 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
decreases expression
increases expression
increases activity
ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP2B9 mRNA
Rifampin results in decreased expression of CYP2B9 mRNA
Rifampin results in increased expression of CYP2B6 mRNA; Rifampin results in increased expression of CYP2B6 protein
[Rifampin co-treated with Monocrotophos] results in increased activity of CYP2B6 protein; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP2B6 mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP2B6 protein; [Rifampin co-treated with NR1I2 protein] results in increased expression of CYP2B6 mRNA; [Rifampin results in increased activity of NR1I2 protein] which results in increased expression of CYP2B6 mRNA; Camptothecin inhibits the reaction [Rifampin results in increased expression of CYP2B6 mRNA]; Dexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP2B6 mRNA]]]; Dexamethasone promotes the reaction [Rifampin results in increased expression of CYP2B6 mRNA]; GW 3965 inhibits the reaction [Rifampin results in increased expression of CYP2B6 mRNA]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of CYP2B6 mRNA]; NR1I2 mRNA promotes the reaction [Rifampin results in increased expression of CYP2B6 mRNA]; NR1I2 protein affects the reaction [Rifampin results in increased expression of and results in increased activity of CYP2B6 protein]; NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP2B6 mRNA]; Rifampin results in increased expression of and results in increased activity of CYP2B6 protein
Rifampin results in increased activity of CYP2B6 protein
CTD PMID:12040753 PMID:12571232 PMID:12695351 PMID:14709624 PMID:14977870 More... NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 decreases expression ISO Rifampin results in decreased expression of CYP2C18 mRNA; Rifampin results in decreased expression of CYP2C18 protein CTD PMID:22258563 PMID:31629065 NCBI chr 1:236,873,967...236,936,238
Ensembl chr 1:236,873,967...236,936,238
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases activity
increases expression
multiple interactions
ISO Rifampin results in increased activity of CYP2C19 protein
Rifampin results in increased expression of CYP2C19 mRNA; Rifampin results in increased expression of CYP2C19 protein
Rifampin results in increased expression of and results in increased activity of CYP2C19 protein
CTD PMID:12584154 PMID:14709624 PMID:15629111 PMID:17954527 PMID:19118567 More... NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 affects binding
increases expression
multiple interactions
increases activity
ISO [Rifampin binds to NR1I2 protein] which binds to CYP2C8 promoter
Rifampin results in increased expression of CYP2C29 mRNA
[Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of BCL2 protein; [Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of MCL1 protein; [Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in increased expression of BAX protein; Camptothecin inhibits the reaction [Rifampin results in increased expression of CYP2C8 mRNA]; pimecrolimus inhibits the reaction [Rifampin results in increased expression of CYP2C8 mRNA]; Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]
[[NR1I3 protein co-treated with NR1I2 protein] results in increased susceptibility to Rifampin] which results in increased expression of CYP2C protein
Rifampin results in increased expression of CYP2C8 mRNA; Rifampin results in increased expression of CYP2C8 protein
Rifampin results in increased activity of CYP2C8 protein
CTD PMID:12040753 PMID:15771232 PMID:15933212 PMID:17954527 PMID:19118567 More...
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases expression
decreases expression
ISO Rifampin results in increased expression of CYP2D6 mRNA
Rifampin results in decreased expression of CYP2D22 mRNA
CTD PMID:19041851 PMID:30503582 PMID:33844597 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases activity
decreases expression
multiple interactions
increases expression
ISO
EXP
Rifampin results in increased activity of CYP2E1 protein
Rifampin results in decreased expression of CYP2E1 mRNA
[[NR1I3 protein co-treated with NR1I2 protein] results in increased susceptibility to Rifampin] which results in decreased expression of CYP2E1 protein
Rifampin results in increased expression of CYP2E1 mRNA; Rifampin results in increased expression of CYP2E1 protein
[Rifampin co-treated with Monocrotophos] results in increased activity of CYP2E1 protein; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP2E1 mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP2E1 protein
[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein; [Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA; [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]; [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA]; Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]; Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA]; Rifampin inhibits the reaction [Isoniazid results in increased expression of CYP2E1 protein]
CTD PMID:15132840 PMID:18071298 PMID:22258563 PMID:22733800 PMID:25835148 More... NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 decreases expression ISO Rifampin results in decreased expression of CYP2F1 mRNA CTD PMID:22258563 NCBI chr 1:82,416,108...82,429,897
Ensembl chr 1:82,416,130...82,429,896
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases expression ISO Rifampin results in decreased expression of CYP2J2 mRNA CTD PMID:33263786 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
JBrowse link
G Cyp2s1 cytochrome P450, family 2, subfamily s, polypeptide 1 multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of CYP2S1 mRNA CTD PMID:21127053 NCBI chr 1:81,309,948...81,325,303
Ensembl chr 1:81,310,451...81,325,303
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
affects activity
increases expression
decreases response to substance
increases activity
EXP
ISO
[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA; [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA]; arsenite inhibits the reaction [Rifampin results in increased expression of and results in increased activity of CYP3A2 protein]; arsenite inhibits the reaction [Rifampin results in increased expression of CYP3A2 mRNA]; Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA]; Rifampin results in increased expression of and results in increased activity of CYP3A2 protein
Rifampin affects the activity of CYP3A4 protein
Rifampin results in increased expression of CYP3A4; Rifampin results in increased expression of CYP3A4 mRNA; Rifampin results in increased expression of CYP3A4 mRNA alternative form; Rifampin results in increased expression of CYP3A4 protein
[[Rifampin results in increased activity of NR1I2 protein] which results in increased activity of CYP3A4 protein] which results in increased metabolism of and results in increased activity of and results in increased susceptibility to Cobicistat; [Dimethyl Sulfoxide results in increased susceptibility to Rifampin] which results in increased expression of CYP3A4 mRNA; [HNF4A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA; [Methylcholanthrene co-treated with Rifampin co-treated with Phenobarbital] results in increased expression of CYP3A4 mRNA; [NR1I2 protein binds to NCOR2 protein] inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; [NR1I2 protein co-treated with Rifampin] results in decreased expression of CYP3A4 mRNA; [PPARGC1A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA; [Rifampin binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; [Rifampin binds to CYP3A4 promoter] which results in increased expression of CYP3A4 mRNA; [Rifampin co-treated with Monocrotophos] results in increased activity of CYP3A4 protein; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP3A4 mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP3A4 protein; [Rifampin co-treated with NR1I2 protein] results in increased expression of CYP3A4 mRNA; [Rifampin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; [Rifampin results in increased expression of CYP3A4 protein] which results in decreased abundance of Ethinyl Estradiol; [Rifampin results in increased expression of CYP3A4 protein] which results in decreased abundance of Midazolam; [Rifampin results in increased expression of CYP3A4 protein] which results in increased hydroxylation of Testosterone; [Rifampin results in increased expression of NR1I2 protein] which results in increased expression of and results in increased activity of CYP3A4 protein; [RXRA protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA; [SRC protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA; [Tetrachlorodibenzodioxin co-treated with Rifampin] results in increased expression of CYP3A4 mRNA; AADAC mRNA affects the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [[HNF4A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [[PPARGC1A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [[RXRA protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [[SRC protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[HNF4A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[PPARGC1A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[RXRA protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[SRC protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]; allyl isothiocyanate inhibits the reaction [Rifampin results in increased activity of CYP3A4 protein]; allyl isothiocyanate inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; allyl isothiocyanate inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein]; Arsenic Trioxide inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein]; Calcitriol promotes the reaction [Rifampin results in increased activity of CYP3A4 protein]; Calcitriol promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; Camptothecin inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; CYP3A4 protein inhibits the reaction [Rifampin results in decreased chemical synthesis of 1-hydroxymethylmidazolam]; CYP3A4 protein inhibits the reaction [Rifampin results in decreased chemical synthesis of 4-hydroxymidazolam]; CYP3A4 protein inhibits the reaction [Rifampin results in decreased hydroxylation of Midazolam]; Dexamethasone promotes the reaction [Rifampin results in increased activity of CYP3A4 protein]; Dichlororibofuranosylbenzimidazole inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; Dimethyl Sulfoxide promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; Econazole promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; Galactosamine inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; GW 3965 inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 protein]]; Ketoconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [Rifampin results in increased activity of CYP3A4 protein]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein]; lorlatinib inhibits the reaction [Rifampin results in increased activity of CYP3A4 protein]; Metformin inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; Metformin inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Rifampin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; NR1H3 mutant form inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; NR1I2 gene promotes the reaction [Rifampin results in increased expression of CYP3A4 protein]; NR1I2 mRNA promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; NR1I2 protein affects the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; NR1I2 protein affects the reaction [Rifampin results in increased expression of CYP3A4 protein]; NR1I2 protein inhibits the reaction [Thapsigargin inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]; NR1I2 protein promotes the reaction [[HNF4A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; NR1I2 protein promotes the reaction [[PPARGC1A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; NR1I2 protein promotes the reaction [[RXRA protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; NR1I2 protein promotes the reaction [[SRC protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]; NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 protein]; NR3C1 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; ochratoxin A inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; ochratoxin A inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein]; oxiconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA]]; periodate-oxidized adenosine inhibits the reaction [Dimethyl Sulfoxide promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]; PRMT1 protein affects the reaction [[Dimethyl Sulfoxide results in increased susceptibility to Rifampin] which results in increased expression of CYP3A4 mRNA]; PRMT1 protein affects the reaction [Dimethyl Sulfoxide promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]; PRMT1 protein affects the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; Rifampin binds to and results in increased activity of CYP3A4 protein; Rifampin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]; Rifampin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam]; Rifampin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; Rifampin promotes the reaction [[HNF4A co-treated with NCOA6] results in increased expression of CYP3A4 mRNA]; Rifampin promotes the reaction [[HNF4A co-treated with NR1I2] results in increased expression of CYP3A4 mRNA]; Rifampin promotes the reaction [[NCOA1 protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA]; Rifampin promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA]; Rifampin promotes the reaction [Calcitriol results in increased expression of CYP3A4 mRNA]; Rifampin promotes the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]; Rifampin promotes the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; Rifampin promotes the reaction [CYP3A4 protein results in increased metabolism of Lidocaine]; Rifampin promotes the reaction [NR1I2 protein binds to CYP3A4 promoter]; Rifampin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]; Rifampin promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA]; Rifampin results in increased expression of and results in increased activity of CYP3A4 protein; Skatole inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; Skatole inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein]; sodium arsenite inhibits the reaction [Rifampin results in increased expression of and results in increased activity of CYP3A4 protein]; sodium arsenite inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; sulforaphane inhibits the reaction [Rifampin results in increased expression of CYP3A4]; Tetrachlorodibenzodioxin inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein]; Thapsigargin inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; trichostatin A affects the reaction [Dimethyl Sulfoxide promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]; trichostatin A promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]
CYP3A4 protein results in decreased susceptibility to Rifampin
[Rifampin results in increased activity of NR1I2 protein] which results in increased activity of CYP3A4 protein; Rifampin results in increased activity of CYP3A4 protein
Rifampin results in increased expression of CYP3A2 mRNA; Rifampin results in increased expression of CYP3A4 mRNA
CTD PMID:8632764 PMID:9298257 PMID:9512926 PMID:10219967 PMID:10640517 More... NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 multiple interactions
increases expression
EXP [Rifampin co-treated with NR1I2 protein] results in increased expression of CYP3A23-3A1 mRNA; arsenite inhibits the reaction [Rifampin results in increased expression of and results in increased activity of CYP3A23-3A1 protein]; arsenite inhibits the reaction [Rifampin results in increased expression of CYP3A23-3A1 mRNA]; Rifampin promotes the reaction [[NR1I2 protein co-treated with RXRA protein] binds to CYP3A23-3A1 promoter]; Rifampin results in increased expression of and results in increased activity of CYP3A23-3A1 protein; sodium arsenite inhibits the reaction [[Rifampin co-treated with NR1I2 protein] results in increased expression of CYP3A23-3A1 mRNA] CTD PMID:12370413 PMID:19041297 PMID:22159698 PMID:22310326 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases expression ISO Rifampin results in increased expression of CYP3A5 mRNA CTD PMID:12040753 PMID:12673034 PMID:15629111 PMID:15681896 PMID:19118567 More... NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions
decreases expression
ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP7A1 mRNA
Rifampin results in decreased expression of CYP7A1 mRNA
NR1I2 protein promotes the reaction [Rifampin results in decreased expression of CYP7A1 mRNA]
CTD PMID:15629111 PMID:21127053 PMID:21224054 PMID:22258563 PMID:24259679 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in decreased expression of CYP8B1 mRNA CTD PMID:21127053 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
JBrowse link
G Dcaf5 DDB1 and CUL4 associated factor 5 decreases expression ISO Rifampin results in decreased expression of DCAF5 mRNA CTD PMID:24552687 NCBI chr 6:99,171,506...99,260,183
Ensembl chr 6:99,171,506...99,260,110
JBrowse link
G Dclre1b DNA cross-link repair 1B decreases expression ISO Rifampin results in decreased expression of DCLRE1B mRNA CTD PMID:24552687 NCBI chr 2:191,309,909...191,318,399
Ensembl chr 2:191,309,913...191,318,423
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of DDIT3 mRNA; [Rifampin co-treated with Cobicistat] results in increased expression of DDIT3 mRNA
4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of DDIT3 mRNA]
Rifampin results in increased expression of DDIT3 mRNA; Rifampin results in increased expression of DDIT3 protein
CTD PMID:21224054 PMID:27470132 PMID:32535746 PMID:33629115 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Dhcr24 24-dehydrocholesterol reductase multiple interactions ISO [Rifampin results in increased activity of NR1I2 protein] which results in increased expression of DHCR24 mRNA CTD PMID:22101211 NCBI chr 5:121,344,637...121,368,853
Ensembl chr 5:121,344,575...121,371,137
JBrowse link
G Dio1 iodothyronine deiodinase 1 increases expression ISO Rifampin results in increased expression of DIO1 mRNA CTD PMID:24552687 NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970
JBrowse link
G Dlx4 distal-less homeobox 4 decreases expression ISO Rifampin results in decreased expression of DLX4 mRNA CTD PMID:24552687 NCBI chr10:80,085,037...80,090,434
Ensembl chr10:80,085,465...80,090,456
JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of DNAJA1 mRNA CTD PMID:21224054 NCBI chr 5:55,842,414...55,853,326
Ensembl chr 5:55,842,426...55,853,967
JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of E2F1 mRNA CTD PMID:21224054 NCBI chr 3:143,064,535...143,075,362 JBrowse link
G Edn1 endothelin 1 multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of EDN1 mRNA CTD PMID:21127053 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Egr1 early growth response 1 multiple interactions ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of EGR1 mRNA
[Rifampin co-treated with NR1I2 protein] results in increased expression of EGR1 mRNA
CTD PMID:21127053 PMID:21224054 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Egr2 early growth response 2 multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of EGR2 mRNA CTD PMID:21127053 NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562
JBrowse link
G Egr4 early growth response 4 multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of EGR4 mRNA CTD PMID:21127053 NCBI chr 4:118,047,869...118,050,328
Ensembl chr 4:118,047,869...118,050,328
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation
increases expression
multiple interactions
EXP
ISO
Rifampin results in increased phosphorylation of EIF2AK3 protein
Rifampin results in increased expression of EIF2AK3 mRNA; Rifampin results in increased expression of EIF2AK3 protein
4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of EIF2AK3 mRNA]; 4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of EIF2AK3 protein]
CTD PMID:24638036 PMID:27470132 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation EXP Rifampin results in increased phosphorylation of EIF2S1 protein CTD PMID:24638036 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Elk1 ETS transcription factor ELK1 decreases expression ISO Rifampin results in decreased expression of ELK1 mRNA CTD PMID:24552687 NCBI chr  X:1,138,826...1,155,713
Ensembl chr  X:1,139,756...1,155,713
JBrowse link
G Epas1 endothelial PAS domain protein 1 multiple interactions ISO [Rifampin co-treated with NR1I2 protein] results in increased expression of EPAS1 mRNA CTD PMID:21127053 NCBI chr 6:7,790,236...7,871,246
Ensembl chr 6:7,790,647...7,871,228
JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression
multiple interactions
ISO Rifampin results in increased expression of EPHX1 mRNA
pimecrolimus inhibits the reaction [Rifampin results in increased expression of EPHX1 mRNA]
CTD PMID:22258563 PMID:25313206 PMID:29356861 NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions
increases expression
ISO Rifampin results in increased expression of and results in increased phosphorylation of ERN1 protein
Rifampin results in increased expression of ERN1 mRNA
CTD PMID:32535746 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Etnppl ethanolamine-phosphate phospho-lyase increases expression ISO Rifampin results in increased expression of ETNPPL mRNA CTD PMID:24552687 NCBI chr 2:219,173,048...219,194,646
Ensembl chr 2:219,172,978...219,192,212
JBrowse link
G F13b coagulation factor XIII B chain increases expression ISO Rifampin results in increased expression of F13B mRNA CTD PMID:24552687 NCBI chr13:51,130,851...51,156,383
Ensembl chr13:51,130,920...51,156,381
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO Mifepristone inhibits the reaction [Rifampin inhibits the reaction [FAS protein results in increased activity of CASP3 protein]]; Mifepristone inhibits the reaction [Rifampin inhibits the reaction [FAS protein results in increased activity of CASP8 protein]]; Mifepristone inhibits the reaction [Rifampin inhibits the reaction [FAS protein results in increased expression of CFLAR protein modified form]]; Mifepristone inhibits the reaction [Rifampin inhibits the reaction [FAS protein results in increased expression of FASLG protein]]; Rifampin inhibits the reaction [FAS protein results in increased activity of CASP3 protein]; Rifampin inhibits the reaction [FAS protein results in increased activity of CASP8 protein]; Rifampin inhibits the reaction [FAS protein results in increased expression of CFLAR protein modified form]; Rifampin inhibits the reaction [FAS protein results in increased expression of FASLG protein] CTD PMID:11958592 PMID:12645856 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand multiple interactions
decreases expression
ISO [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FASL mRNA
Rifampin results in decreased expression of FASLG mRNA; Rifampin results in decreased expression of FASLG protein
Mifepristone inhibits the reaction [Rifampin inhibits the reaction [FAS protein results in increased expression of FASLG protein]]; Rifampin inhibits the reaction [FAS protein results in increased expression of FASLG protein]
CTD PMID:11958592 PMID:12645856 PMID:21224054 PMID:24552687 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fasn fatty acid synthase increases expression
multiple interactions