linuron - Ontology Report - Rat Genome Database

Submit Data | Help | Video Tutorials | News | Publications | Download | REST API | Citing RGD | Contact

Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

{{ watchLinkText }}

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	linuron	go back to main search page
Accession:	CHEBI:6482	browse the term
Definition:	A member of the class of phenylureas that is N-methyl urea substituted by a methoxy group at position 1 and a 3,4-dichlorophenyl group at position 3.
Synonyms:	related_synonym:	1-Methoxy-1-methyl-3-(3,4-dichlorophenyl)urea; 3-(3,4-dichlorophenyl)-1-methoxy-1-methylurea; Formula=C9H10Cl2N2O2; InChI=1S/C9H10Cl2N2O2/c1-13(15-2)9(14)12-6-3-4-7(10)8(11)5-6/h3-5H,1-2H3,(H,12,14); InChIKey=XKJMBINCVNINCA-UHFFFAOYSA-N; N'-(3,4-dichlorophenyl)-N-methoxy-N-methyl Urea; SMILES=CON(C)C(=O)Nc1ccc(Cl)c(Cl)c1
	xref:	CAS:330-55-2; KEGG:C11007
	xref_mesh:	MESH:D008044
	xref:	PMID:23586778; PMID:24410802; PMID:25238184; PPDB:419; Pesticides:linuron; Reaxys:2128725

show annotations for term's descendants Sort by:
Rat (193) Mouse (190) Human (192) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (193)

linuron

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

actinin, alpha 1

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of ACTN1 mRNA

NCBI chr 6:104,731,485...104,826,312
Ensembl chr 6:98,998,556...99,093,251

G

aryl hydrocarbon receptor

multiple interactions
increases expression

Linuron binds to and results in increased activity of AHR protein; SIGMAR1 gene promotes the reaction [Linuron results in increased expression of AHR mRNA]; XBP1 gene promotes the reaction [Linuron results in increased expression of AHR mRNA]

PMID:18835618 PMID:30661753

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568

G

apoptotic peptidase activating factor 1

increases expression

Linuron results in increased expression of APAF1 mRNA

NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:25,494,609...25,579,540

G

androgen receptor

multiple interactions
decreases activity
increases expression
decreases expression
affects binding
affects activity

Dihydrotestosterone inhibits the reaction [Linuron results in increased activity of AR protein]; Linuron binds to and results in decreased activity of AR protein; Linuron inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; Linuron inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; Linuron inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; Linuron inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; Linuron inhibits the reaction [Metribolone binds to AR protein]; Linuron inhibits the reaction [Metribolone results in increased activity of AR protein]; Linuron inhibits the reaction [Stanozolol binds to and results in increased activity of AR protein]; Linuron inhibits the reaction [Testosterone results in increased activity of AR protein]; methoxyacetic acid inhibits the reaction [Linuron inhibits the reaction [Testosterone results in increased activity of AR protein]]
Linuron results in decreased activity of AR protein
Linuron results in increased expression of AR mRNA
Linuron binds to and results in decreased activity of AR protein; Linuron inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; Linuron inhibits the reaction [Metribolone binds to AR protein]
Linuron results in decreased expression of AR mRNA
Linuron binds to AR protein
Linuron affects the activity of AR protein

PMID:10910998 PMID:10964759 PMID:11861974 PMID:12730624 PMID:14565775 More...

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:63,104,771...63,273,925

G

arginase 1

increases expression
multiple interactions

Linuron results in increased expression of ARG1 mRNA
SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of ARG1 mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of ARG1 mRNA]

NCBI chr 1:22,295,093...22,307,720
Ensembl chr 1:20,475,968...20,488,422

G

aryl hydrocarbon receptor nuclear translocator

multiple interactions

XBP1 gene promotes the reaction [Linuron results in increased expression of ARNT mRNA]

NCBI chr 2:185,686,703...185,745,546
Ensembl chr 2:182,997,736...183,056,580

G

arginine vasopressin

multiple interactions

[Plasticizers co-treated with Fungicides, Industrial co-treated with Linuron co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with Dichlorodiphenyl Dichloroethylene co-treated with butylparaben co-treated with Acetaminophen] results in decreased expression of AVP mRNA

NCBI chr 3:138,246,544...138,248,522
Ensembl chr 3:117,793,457...117,795,425

G

beta-secretase 1

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of BACE1 mRNA

NCBI chr 8:55,038,842...55,061,138
Ensembl chr 8:46,142,116...46,165,876

G

beta-secretase 2

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of BACE2 mRNA

NCBI chr11:50,176,852...50,258,948
Ensembl chr11:36,707,458...36,789,546

G

BCL2 associated X, apoptosis regulator

increases expression

Linuron results in increased expression of BAX mRNA

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368

G

brain-derived neurotrophic factor

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of BDNF mRNA

NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615

G

beclin 1

increases expression

Linuron results in increased expression of BECN1 mRNA

NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,231,388...86,246,742

G

bone morphogenetic protein 4

decreases expression

Linuron results in decreased expression of BMP4 mRNA

NCBI chr15:22,098,191...22,113,145
Ensembl chr15:19,618,542...19,623,306

G

bone morphogenetic protein receptor type 1B

decreases expression

Linuron results in decreased expression of BMPR1B mRNA

NCBI chr 2:233,211,525...233,544,344
Ensembl chr 2:230,541,558...230,871,368

G

bassoon (presynaptic cytomatrix protein)

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of BSN mRNA

NCBI chr 8:117,663,447...117,754,412
Ensembl chr 8:108,788,542...108,875,819

G

calcium voltage-gated channel subunit alpha1 A

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1A mRNA

NCBI chr19:40,425,560...40,724,810
Ensembl chr19:23,520,741...23,823,225

G

calcium voltage-gated channel subunit alpha1 B

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1B mRNA

NCBI chr 3:27,779,133...27,944,292
Ensembl chr 3:7,380,922...7,546,091

G

calcium voltage-gated channel subunit alpha1 C

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1C mRNA

NCBI chr 4:153,431,169...154,051,932
Ensembl chr 4:151,764,138...152,379,648

G

calcium voltage-gated channel subunit alpha1 D

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1D mRNA

NCBI chr16:5,233,682...5,527,549
Ensembl chr16:5,228,306...5,668,215

G

calcium voltage-gated channel subunit alpha1 G

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1G mRNA

NCBI chr10:79,851,886...79,919,926
Ensembl chr10:79,355,008...79,422,752

G

calcium voltage-gated channel subunit alpha1 I

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of CACNA1I mRNA

NCBI chr 7:113,716,266...113,827,670
Ensembl chr 7:111,836,012...111,944,688

G

calcium voltage-gated channel auxiliary subunit alpha2delta 3

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of CACNA2D3 mRNA

NCBI chr16:4,105,048...4,919,037
Ensembl chr16:4,098,445...4,912,351

G

calcium voltage-gated channel auxiliary subunit beta 1

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNB1 mRNA

NCBI chr10:83,494,509...83,515,164
Ensembl chr10:82,998,182...83,018,694

G

calcium voltage-gated channel auxiliary subunit beta 3

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNB3 mRNA

NCBI chr 7:131,663,810...131,676,085
Ensembl chr 7:129,783,674...129,797,074

G

calcium voltage-gated channel auxiliary subunit gamma 2

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of CACNG2 mRNA

NCBI chr 7:111,451,605...111,579,071
Ensembl chr 7:109,574,459...109,697,227

G

calcium voltage-gated channel auxiliary subunit gamma 6

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of CACNG6 mRNA

NCBI chr 1:74,648,342...74,663,351
Ensembl chr 1:65,732,632...65,747,341

G

calcium voltage-gated channel auxiliary subunit gamma 7

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNG7 mRNA

NCBI chr 1:74,715,483...74,746,669
Ensembl chr 1:65,800,355...65,831,006

G

cell adhesion molecule 1

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of CADM1 mRNA

NCBI chr 8:56,744,374...57,075,264
Ensembl chr 8:47,847,325...48,182,833

G

calcium/calmodulin-dependent protein kinase II beta

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CAMK2B mRNA

NCBI chr14:85,059,166...85,148,121
Ensembl chr14:80,845,238...80,933,994

G

calcium/calmodulin-dependent protein kinase II gamma

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of CAMK2G mRNA

NCBI chr15:3,553,238...3,612,310
Ensembl chr15:3,504,085...3,563,050

G

CART prepropeptide

multiple interactions

[Plasticizers co-treated with Fungicides, Industrial co-treated with Linuron co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with Dichlorodiphenyl Dichloroethylene co-treated with butylparaben co-treated with Acetaminophen] results in increased expression of CARTPT mRNA

NCBI chr 2:32,989,215...32,991,794
Ensembl chr 2:31,255,098...31,290,713

G

caspase 3

increases expression

Linuron results in increased expression of CASP3 mRNA

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

C-C motif chemokine ligand 1

increases expression
multiple interactions

Linuron results in increased expression of CCL1 mRNA
SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of CCL1 mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of CCL1 mRNA]

NCBI chr10:67,625,962...67,628,740
Ensembl chr10:67,128,331...67,131,159

G

C-C motif chemokine ligand 17

multiple interactions
increases expression

SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of CCL17 mRNA]

NCBI chr19:10,208,120...10,218,340
Ensembl chr19:10,202,128...10,203,819

G

C-C motif chemokine ligand 2

increases expression
multiple interactions

Linuron results in increased expression of CCL2 mRNA
1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of CCL2 mRNA]]; Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of CCL2 mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of CCL2 mRNA]

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 20

increases expression
multiple interactions

Linuron results in increased expression of CCL20 mRNA
SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of CCL20 mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of CCL20 mRNA]

NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:84,388,904...84,391,629

G

C-C motif chemokine ligand 4

increases expression
multiple interactions

Linuron results in increased expression of CCL4 mRNA
SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of CCL4 mRNA]

NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,452,052...68,468,231

G

C-C motif chemokine receptor 2

multiple interactions
increases expression

SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of CCR2 mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of CCR2 mRNA]

NCBI chr 8:132,611,883...132,619,106
Ensembl chr 8:123,734,430...123,742,100

G

CD44 molecule

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of CD44 mRNA

NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:89,157,058...89,244,620

G

Cd81 molecule

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CD81 mRNA

NCBI chr 1:207,665,274...207,681,094
Ensembl chr 1:198,241,484...198,251,660

G

cyclin dependent kinase 2

decreases expression

Linuron results in decreased expression of CDK2 mRNA

NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase inhibitor 1A

increases expression

Linuron results in increased expression of CDKN1A mRNA

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585

G

chromogranin A

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CHGA mRNA

NCBI chr 6:127,460,895...127,472,238
Ensembl chr 6:121,696,051...121,707,398

G

ciliary neurotrophic factor

multiple interactions
increases expression

XBP1 gene promotes the reaction [Linuron results in increased expression of CNTF mRNA]

NCBI chr 1:219,312,512...219,314,535
Ensembl chr 1:209,887,854...209,889,877

G

cytochrome c oxidase subunit 7A2

increases expression

Linuron results in increased expression of COX7A2 mRNA

NCBI chr 8:89,597,051...89,611,032
Ensembl chr14:51,301,168...51,301,633
Ensembl chr 8:51,301,168...51,301,633

G

corticotropin releasing hormone

multiple interactions

[Plasticizers co-treated with Fungicides, Industrial co-treated with Linuron co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with Dichlorodiphenyl Dichloroethylene co-treated with butylparaben co-treated with Acetaminophen] affects the expression of CRH mRNA

NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:102,143,055...102,144,919

G

colony stimulating factor 2

increases expression
multiple interactions

Linuron results in increased expression of CSF2 mRNA
1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of CSF2 mRNA]]; Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of CSF2 mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of CSF2 mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of CSF2 mRNA]

NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,386,945...38,389,199

G

chondroitin sulfate proteoglycan 4

multiple interactions
increases expression

SIGMAR1 gene promotes the reaction [Linuron results in increased expression of CSPG4 mRNA]; XBP1 gene promotes the reaction [Linuron results in increased expression of CSPG4 mRNA]

NCBI chr 8:66,160,942...66,195,987
Ensembl chr 8:57,264,962...57,300,010

G

C-X-C motif chemokine ligand 10

increases expression
multiple interactions

Linuron results in increased expression of CXCL10 mRNA
SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of CXCL10 mRNA]

NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 12

increases expression
multiple interactions

Linuron results in increased expression of CXCL12 mRNA
XBP1 gene promotes the reaction [Linuron results in increased expression of CXCL12 mRNA]

NCBI chr 4:152,060,781...152,073,628
Ensembl chr 4:150,388,325...150,401,168

G

cytochrome P450, family 11, subfamily a, polypeptide 1

decreases expression

Linuron results in decreased expression of CYP11A1 mRNA; Linuron results in decreased expression of CYP11A1 protein

PMID:28007637 PMID:28705778

NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 17, subfamily a, polypeptide 1

decreases expression

Linuron results in decreased expression of CYP17A1 mRNA

PMID:28007637 PMID:28705778

NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 19, subfamily a, polypeptide 1

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of CYP19A1 mRNA

NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases activity

Linuron results in increased activity of CYP1A1 protein

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases response to substance

CYP1A2 protein results in decreased susceptibility to Linuron

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

increases expression
multiple interactions

Linuron results in increased expression of CYP1B1 mRNA
XBP1 gene promotes the reaction [Linuron results in increased expression of CYP1B1 mRNA]

PMID:16040568 PMID:30661753

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily b, polypeptide 1

affects activity

Linuron affects the activity of CYP2B1 protein

NCBI chr 1:90,646,098...90,669,762
Ensembl chr 1:81,518,408...81,542,052

G

cytochrome P450, family 2, subfamily b, polypeptide 2

affects activity

Linuron affects the activity of CYP2B2 protein

NCBI chr 1:90,722,243...90,736,272
Ensembl chr 1:81,594,555...81,608,566

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions

[Chlorfenvinphos co-treated with ethion co-treated with Linuron] results in increased expression of CYP3A4 mRNA

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008

G

DCC netrin 1 receptor

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of DCC mRNA

NCBI chr18:67,144,272...68,248,159
Ensembl chr18:64,873,898...65,972,740

G

DEAD-box helicase 4

increases expression

Linuron results in increased expression of DDX4 mRNA

NCBI chr 2:45,961,174...46,016,097
Ensembl chr 2:44,227,946...44,282,723

G

discs large MAGUK scaffold protein 1

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of DLG1 mRNA

NCBI chr11:82,416,853...82,607,797
Ensembl chr11:68,911,883...69,102,689

G

discs large MAGUK scaffold protein 4

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of DLG4 mRNA; [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of DLG4 mRNA

NCBI chr10:55,239,397...55,267,780
Ensembl chr10:54,739,470...54,767,153

G

DLG associated protein 3

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of DLGAP3 mRNA

NCBI chr 5:139,491,972...139,562,625
Ensembl chr 5:139,492,947...139,562,625

G

DLG associated protein 4

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of DLGAP4 mRNA

NCBI chr 3:145,124,189...145,271,791
Ensembl chr 3:145,175,479...145,270,490

G

delta like canonical Notch ligand 1

increases expression

Linuron results in increased expression of DLL1 mRNA

NCBI chr 1:64,985,161...64,993,274
Ensembl chr 1:56,312,066...56,320,179

G

dynamin 1

multiple interactions

[Plasticizers co-treated with Fungicides, Industrial co-treated with Linuron co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with Dichlorodiphenyl Dichloroethylene co-treated with butylparaben co-treated with Acetaminophen] results in decreased expression of DNM1 mRNA

NCBI chr 3:36,002,535...36,055,220
Ensembl chr 3:15,604,784...15,648,538

G

double C2 domain alpha

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of DOC2A mRNA

NCBI chr 1:190,887,306...190,893,057
Ensembl chr 1:181,458,390...181,462,030

G

dipeptidyl peptidase like 10

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of DPP10 mRNA

NCBI chr13:37,145,531...38,821,987
Ensembl chr13:34,595,868...36,269,292

G

dipeptidyl peptidase like 6

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of DPP6 mRNA

NCBI chr 4:8,323,220...9,242,694
Ensembl chr 4:7,591,009...8,508,532

G

dihydropyrimidine dehydrogenase

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of DPYD mRNA

NCBI chr 2:209,293,902...210,159,777
Ensembl chr 2:206,609,122...207,474,982

G

epidermal growth factor

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of EGF mRNA

NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:218,219,415...218,302,064

G

epidermal growth factor receptor

decreases expression
multiple interactions

Linuron results in decreased expression of EGFR mRNA
[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of EGFR mRNA

PMID:12730624 PMID:25607892

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:91,177,067...91,344,382

G

eukaryotic translation initiation factor 4E

decreases expression

Linuron results in decreased expression of EIF4E mRNA

NCBI chr 2:229,736,309...229,772,628
Ensembl chr 2:227,066,673...227,098,683

G

ectonucleoside triphosphate diphosphohydrolase 1

increases expression
multiple interactions

Linuron results in increased expression of ENTPD1 mRNA
SIGMAR1 gene promotes the reaction [Linuron results in increased expression of ENTPD1 mRNA]; XBP1 gene promotes the reaction [Linuron results in increased expression of ENTPD1 mRNA]

NCBI chr 1:249,374,810...249,502,310
Ensembl chr 1:239,425,430...239,552,317

G

erb-b2 receptor tyrosine kinase 2

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of ERBB2 mRNA

NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,411,313...83,435,078

G

erb-b2 receptor tyrosine kinase 3

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of ERBB3 mRNA

NCBI chr 7:1,579,079...1,600,379
Ensembl chr 7:996,225...1,015,525

G

erb-b2 receptor tyrosine kinase 4

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of ERBB4 mRNA; [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of ERBB4 mRNA

NCBI chr 9:76,973,386...78,045,633
Ensembl chr 9:69,531,481...70,596,595

G

endoplasmic reticulum to nucleus signaling 1

increases activity
multiple interactions

Linuron results in increased activity of ERN1 protein
1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of ERN1 protein modified form]]
Linuron promotes the reaction [ERN1 protein binds to SIGMAR1 protein]

NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,330,654...91,421,029

G

estrogen receptor 1

multiple interactions

Linuron binds to and results in increased activity of ESR1 protein
[Plasticizers co-treated with Fungicides, Industrial co-treated with Linuron co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with Dichlorodiphenyl Dichloroethylene co-treated with butylparaben co-treated with Acetaminophen] results in decreased expression of ESR1 mRNA

PMID:33049310 PMID:34383603

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

multiple interactions

Linuron binds to and results in increased activity of ESR2 protein

NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:94,809,547...94,908,919

G

fibroblast growth factor receptor 2

decreases expression

Linuron results in decreased expression of FGFR2 mRNA

NCBI chr 1:194,175,703...194,280,914
Ensembl chr 1:184,745,420...184,850,626

G

fragile X messenger ribonucleoprotein 1

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of FMR1 mRNA

NCBI chr X:152,284,857...152,322,686
Ensembl chr X:147,240,301...147,278,050

G

follicle stimulating hormone receptor

decreases expression

Linuron results in decreased expression of FSHR mRNA

NCBI chr 6:10,952,329...11,160,288
Ensembl chr 6:5,198,825...5,406,785

G

FYN proto-oncogene, Src family tyrosine kinase

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of FYN mRNA

NCBI chr20:44,322,635...44,514,498
Ensembl chr20:42,766,369...42,959,911

G

gamma-aminobutyric acid type A receptor subunit alpha 4

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GABRA4 mRNA

NCBI chr14:36,944,747...37,021,652
Ensembl chr14:36,590,782...36,665,844

G

gamma-aminobutyric acid type A receptor subunit beta1

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GABRB1 mRNA

NCBI chr14:36,434,339...36,917,920
Ensembl chr14:36,080,393...36,548,948

G

glial cell derived neurotrophic factor

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GDNF mRNA

NCBI chr 2:58,621,327...58,647,242
Ensembl chr 2:56,895,010...56,917,209

G

glutaminase

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GLS mRNA

NCBI chr 9:56,836,584...56,908,861
Ensembl chr 9:49,344,781...49,416,900

G

glypican 1

decreases expression

Linuron results in decreased expression of GPC1 mRNA

NCBI chr 9:100,843,645...100,871,458
Ensembl chr 9:93,396,234...93,424,047

G

glutamate ionotropic receptor AMPA type subunit 2

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GRIA2 mRNA

NCBI chr 2:168,247,490...168,367,616
Ensembl chr 2:165,947,521...166,069,510

G

glutamate ionotropic receptor AMPA type subunit 4

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GRIA4 mRNA

NCBI chr 8:9,845,421...10,320,021
Ensembl chr 8:1,562,119...2,034,979

G

glutamate ionotropic receptor delta type subunit 2

multiple interactions

[Plasticizers co-treated with Fungicides, Industrial co-treated with Linuron co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with Dichlorodiphenyl Dichloroethylene co-treated with butylparaben co-treated with Acetaminophen] results in decreased expression of GRID2 mRNA

NCBI chr 4:93,745,165...95,222,354
Ensembl chr 4:92,415,230...93,889,355

G

glutamate ionotropic receptor kainate type subunit 1

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of GRIK1 mRNA

NCBI chr11:40,655,974...41,056,966
Ensembl chr11:27,169,740...27,570,645

G

glutamate ionotropic receptor kainate type subunit 2

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GRIK2 mRNA

NCBI chr20:53,717,564...54,415,283
Ensembl chr20:52,133,851...52,838,375

G

glutamate ionotropic receptor NMDA type subunit 1

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of GRIN1 mRNA

NCBI chr 3:28,501,836...28,528,754
Ensembl chr 3:8,103,680...8,130,603

G

glutamate ionotropic receptor NMDA type subunit 2B

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of GRIN2B mRNA

NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:168,599,546...169,042,279

G

glutamate ionotropic receptor NMDA type subunit 2D

multiple interactions

[Plasticizers co-treated with Fungicides, Industrial co-treated with Linuron co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with Dichlorodiphenyl Dichloroethylene co-treated with butylparaben co-treated with Acetaminophen] results in decreased expression of GRIN2D mRNA

NCBI chr 1:105,443,317...105,483,400
Ensembl chr 1:96,308,365...96,344,793

G

glutamate receptor interacting protein 1

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GRIP1 mRNA

NCBI chr 7:56,820,501...57,477,877
Ensembl chr 7:54,934,250...55,592,273

G

hemoglobin subunit gamma 1

decreases expression

Linuron results in decreased expression of HBG1 mRNA

NCBI chr 1:158,271,871...158,273,426
Ensembl chr 1:158,271,873...158,273,425

G

hes family bHLH transcription factor 6

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of HES6 mRNA

NCBI chr 9:92,001,849...92,003,562
Ensembl chr 9:92,001,841...92,003,559

G

hypoxia inducible factor 1 subunit alpha

increases expression
multiple interactions

Linuron results in increased expression of HIF1A mRNA
XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of HIF1A mRNA]

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261

G

hydroxysteroid (17-beta) dehydrogenase 3

decreases expression

Linuron results in decreased expression of HSD17B3 mRNA

NCBI chr17:1,032,958...1,064,283
Ensembl chr17:1,027,229...1,058,554

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

decreases expression

Linuron results in decreased expression of HSD3B1 mRNA

NCBI chr 2:188,858,574...188,864,694
Ensembl chr 2:186,169,863...186,175,999

G

isopentenyl-diphosphate delta isomerase 1

decreases expression

Linuron results in decreased expression of IDI1 mRNA

NCBI chr17:66,539,761...66,547,524
Ensembl chr17:61,629,594...61,637,357

G

interferon alpha and beta receptor subunit 1

multiple interactions
increases expression

SIGMAR1 gene promotes the reaction [Linuron results in increased expression of IFNAR1 mRNA]; XBP1 gene promotes the reaction [Linuron results in increased expression of IFNAR1 mRNA]

NCBI chr11:44,211,769...44,238,206
Ensembl chr11:30,725,790...30,749,979

G

interferon beta 1

multiple interactions
increases expression

SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of IFNB1 mRNA]

NCBI chr 5:108,066,650...108,067,487
Ensembl chr 5:103,020,969...103,021,523

G

interferon gamma

increases expression
multiple interactions

Linuron results in increased expression of IFNG mRNA
SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of IFNG mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of IFNG mRNA]

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375

G

insulin-like growth factor 1

increases expression

Linuron results in increased expression of IGF1 mRNA

NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor 1 receptor

decreases expression

Linuron results in decreased expression of IGF1R mRNA

NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:121,550,743...121,831,777

G

insulin-like growth factor 2 receptor

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of IGF2R mRNA

NCBI chr 1:50,526,878...50,615,265
Ensembl chr 1:47,979,109...48,067,501

G

insulin-like growth factor binding protein 5

decreases expression

Linuron results in decreased expression of IGFBP5 mRNA

NCBI chr 9:81,901,605...81,914,187
Ensembl chr 9:74,448,382...74,465,156

G

interleukin 10

increases expression
multiple interactions

Linuron results in increased expression of IL10 mRNA
XBP1 gene promotes the reaction [Linuron results in increased expression of IL10 mRNA]

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313

G

interleukin 10 receptor subunit alpha

multiple interactions
increases expression

SIGMAR1 gene promotes the reaction [Linuron results in increased expression of IL10RA mRNA]

NCBI chr 8:54,459,754...54,474,786
Ensembl chr 8:45,563,137...45,578,061

G

interleukin 13

increases expression
multiple interactions

Linuron results in increased expression of IL13 mRNA
XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of IL13 mRNA]

NCBI chr10:38,290,926...38,293,483
Ensembl chr10:37,790,130...37,792,737

G

interleukin 1 beta

multiple interactions
increases expression

1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with Linuron] results in increased expression of RELA protein modified form]; 1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with Linuron] results in increased expression of XBP1 protein modified form]; 1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with Linuron] results in increased splicing of XBP1 mRNA]; 1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of CCL2 mRNA]]; 1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of CSF2 mRNA]]; 1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of ERN1 protein modified form]]; 1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of IL6 mRNA]]; 1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]]; [IL1B protein co-treated with TNF protein co-treated with Linuron] promotes the reaction [XBP1 protein binds to NOS2 promoter]; [IL1B protein co-treated with TNF protein co-treated with Linuron] results in increased expression of RELA protein modified form; [IL1B protein co-treated with TNF protein co-treated with Linuron] results in increased expression of XBP1 protein modified form; [IL1B protein co-treated with TNF protein co-treated with Linuron] results in increased splicing of XBP1 mRNA; [IL1B protein co-treated with TNF protein] results in increased susceptibility to Linuron; Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of CCL2 mRNA]; Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of CSF2 mRNA]; Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of IL6 mRNA]; Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of IL1B mRNA]; STF 083010 inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of IL1B mRNA]
1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]]; Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]; STF 083010 inhibits the reaction [[Linuron co-treated with IL1B protein co-treated with TNF protein] results in increased splicing of XBP1 mRNA]; STF 083010 inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor accessory protein-like 1

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of IL1RAPL1 mRNA

NCBI chr X:51,371,969...52,876,726
Ensembl chr X:51,378,215...52,876,772

G

interleukin 21

increases expression
multiple interactions

Linuron results in increased expression of IL21 mRNA
SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of IL21 mRNA]

NCBI chr 2:122,045,240...122,055,142
Ensembl chr 2:120,119,444...120,126,996

G

interleukin 23 subunit alpha

increases expression
multiple interactions

Linuron results in increased expression of IL23A mRNA
SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of IL23A mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of IL23A mRNA]

NCBI chr 7:1,306,320...1,308,434
Ensembl chr 7:721,809...723,923

G

interleukin 5

increases expression
multiple interactions

Linuron results in increased expression of IL5 mRNA
XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of IL5 mRNA]

NCBI chr10:38,375,132...38,378,003
Ensembl chr10:37,874,342...37,877,213

G

interleukin 6

multiple interactions
increases expression

1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of IL6 mRNA]]; Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of IL6 mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of IL6 mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of IL6 mRNA]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178

G

inhibin subunit alpha

decreases expression

Linuron results in decreased expression of INHA mRNA

NCBI chr 9:84,443,109...84,446,010
Ensembl chr 9:76,993,589...76,997,248

G

inhibin subunit beta A

decreases expression

Linuron results in decreased expression of INHBA mRNA

NCBI chr17:53,787,159...53,810,942
Ensembl chr17:49,095,920...49,108,982

G

interferon regulatory factor 3

increases expression
multiple interactions

Linuron results in increased expression of IRF3 mRNA
XBP1 gene promotes the reaction [Linuron results in increased expression of IRF3 mRNA]

NCBI chr 1:104,616,608...104,621,402
Ensembl chr 1:95,479,821...95,484,935

G

interferon regulatory factor 7

increases expression
multiple interactions

Linuron results in increased expression of IRF7 mRNA
XBP1 gene promotes the reaction [Linuron results in increased expression of IRF7 mRNA]

NCBI chr 1:205,796,956...205,800,543
Ensembl chr 1:196,367,361...196,370,832

G

interferon regulatory factor 9

increases expression
multiple interactions

Linuron results in increased expression of IRF9 mRNA
XBP1 gene promotes the reaction [Linuron results in increased expression of IRF9 mRNA]

NCBI chr15:33,065,422...33,071,881
Ensembl chr15:29,095,789...29,101,236

G

KiSS-1 metastasis-suppressor

multiple interactions

[Plasticizers co-treated with Fungicides, Industrial co-treated with Linuron co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with Dichlorodiphenyl Dichloroethylene co-treated with butylparaben co-treated with Acetaminophen] results in decreased expression of KISS1 mRNA

NCBI chr13:47,327,159...47,332,759
Ensembl chr13:44,774,823...44,780,612

G

kallikrein 1-related peptidase C10

decreases expression
increases secretion

Linuron results in decreased expression of KLK3 mRNA
Linuron results in increased secretion of KLK3 protein

PMID:20363314 PMID:33932781

NCBI chr 1:103,539,527...103,543,586
Ensembl chr 1:94,402,993...94,407,052

G

luteinizing hormone/choriogonadotropin receptor

decreases expression

Linuron results in decreased expression of LHCGR mRNA

NCBI chr 6:11,415,361...11,480,834
Ensembl chr 6:5,661,871...5,724,521

G

LIF, interleukin 6 family cytokine

increases expression
multiple interactions

Linuron results in increased expression of LIF mRNA
SIGMAR1 gene promotes the reaction [Linuron results in increased expression of LIF mRNA]; XBP1 gene promotes the reaction [Linuron results in increased expression of LIF mRNA]

NCBI chr14:83,354,602...83,364,053
Ensembl chr14:79,134,574...79,140,482

G

leucine rich repeat containing 7

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of LRRC7 mRNA

NCBI chr 2:249,792,441...250,294,267
Ensembl chr 2:247,147,752...247,634,547

G

membrane associated guanylate kinase, WW and PDZ domain containing 2

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of MAGI2 mRNA

NCBI chr 4:15,278,518...16,762,427
Ensembl chr 4:14,386,399...15,870,240

G

MAM domain containing glycosylphosphatidylinositol anchor 2

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of MDGA2 mRNA

NCBI chr 6:90,482,687...91,346,784
Ensembl chr 6:84,761,941...85,608,126

G

mitofusin 2

decreases expression

Linuron results in decreased expression of MFN2 mRNA

NCBI chr 5:163,587,463...163,617,363
Ensembl chr 5:158,304,287...158,335,342

G

matrix metallopeptidase 12

increases expression
multiple interactions

Linuron results in increased expression of MMP12 mRNA
SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of MMP12 mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of MMP12 mRNA]

NCBI chr 8:12,866,652...12,876,554
Ensembl chr 8:4,581,785...4,599,611

G

microseminoprotein, beta

decreases expression

Linuron results in decreased expression of MSMB mRNA

NCBI chr16:7,366,536...7,387,124
Ensembl chr16:7,366,536...7,387,123

G

MYC proto-oncogene, bHLH transcription factor

decreases expression

Linuron results in decreased expression of MYC mRNA

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630

G

myomesin 2

increases expression

Linuron results in increased expression of MYOM2 mRNA

NCBI chr16:81,222,467...81,295,025
Ensembl chr16:74,520,157...74,592,772

G

neurofibromin 1

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NF1 mRNA

NCBI chr10:64,803,986...65,037,086
Ensembl chr10:64,306,301...64,536,658

G

neuroligin 1

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NLGN1 mRNA

NCBI chr 2:110,184,987...111,110,316
Ensembl chr 2:108,257,824...109,002,464

G

nitric oxide synthase 2

increases expression
multiple interactions

Linuron results in increased expression of NOS2 mRNA
1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]]; [IL1B protein co-treated with TNF protein co-treated with Linuron] promotes the reaction [XBP1 protein binds to NOS2 promoter]; Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of NOS2 mRNA]; STF 083010 inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of NOS2 mRNA]
1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]]; Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]; STF 083010 inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]]

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210

G

notch receptor 2

decreases expression
multiple interactions

Linuron results in decreased expression of NOTCH2 mRNA
[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of NOTCH2 mRNA

PMID:12730624 PMID:25607892

NCBI chr 2:188,299,336...188,432,823
Ensembl chr 2:185,610,589...185,744,088

G

notch receptor 3

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of NOTCH3 mRNA

NCBI chr 7:11,783,550...11,834,585
Ensembl chr 7:11,133,706...11,184,025

G

notch receptor 4

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NOTCH4 mRNA

NCBI chr20:4,164,969...4,189,072
Ensembl chr20:4,160,445...4,184,465

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions

Linuron binds to and results in increased activity of NR1I2 protein
[Chlorfenvinphos co-treated with ethion co-treated with Linuron] results in increased activity of NR1I2 protein; Linuron binds to and results in increased activity of NR1I2 protein

PMID:21115097 PMID:25028461 PMID:33049310

NCBI chr11:75,965,717...76,006,733
Ensembl chr11:62,460,213...62,496,658

G

nuclear receptor subfamily 3, group C, member 1

multiple interactions

[Plasticizers co-treated with Fungicides, Industrial co-treated with Linuron co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with Dichlorodiphenyl Dichloroethylene co-treated with butylparaben co-treated with Acetaminophen] results in decreased expression of NR3C1 mRNA

NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,271,681...31,393,375

G

neuronal cell adhesion molecule

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of NRCAM mRNA

NCBI chr 6:67,129,723...67,425,510
Ensembl chr 6:61,329,863...61,702,992

G

neuregulin 1

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NRG1 mRNA; [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of NRG1 mRNA

NCBI chr16:65,954,084...67,007,484
Ensembl chr16:59,250,854...60,296,884

G

neurexin 1

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of NRXN1 mRNA

NCBI chr 6:8,931,360...10,077,381
Ensembl chr 6:3,177,897...4,322,710

G

neurexin 2

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NRXN2 mRNA

NCBI chr 1:213,155,673...213,271,526
Ensembl chr 1:203,735,753...203,842,297

G

neurotrophic receptor tyrosine kinase 2

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NTRK2 mRNA

NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,559,043...5,869,136

G

oxytocin/neurophysin I prepropeptide

multiple interactions

[Plasticizers co-treated with Fungicides, Industrial co-treated with Linuron co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with Dichlorodiphenyl Dichloroethylene co-treated with butylparaben co-treated with Acetaminophen] results in decreased expression of OXT mRNA

NCBI chr 3:138,235,754...138,236,594
Ensembl chr 3:117,782,650...117,783,490

G

proliferating cell nuclear antigen

decreases expression

Linuron results in decreased expression of PCNA mRNA; Linuron results in decreased expression of PCNA protein

PMID:28007637 PMID:28705778

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995

G

progesterone receptor

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of PGR mRNA

NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:6,072,673...6,131,344

G

proopiomelanocortin

multiple interactions

[Plasticizers co-treated with Fungicides, Industrial co-treated with Linuron co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with Dichlorodiphenyl Dichloroethylene co-treated with butylparaben co-treated with Acetaminophen] affects the expression of POMC mRNA

NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:26,939,837...26,945,664

G

peroxisome proliferator-activated receptor gamma

multiple interactions

Linuron binds to and results in increased activity of PPARG protein

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468

G

protein phosphatase 1, regulatory (inhibitor) subunit 1B

multiple interactions

[Plasticizers co-treated with Fungicides, Industrial co-treated with Linuron co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with Dichlorodiphenyl Dichloroethylene co-treated with butylparaben co-treated with Acetaminophen] results in decreased expression of PPP1R1B mRNA

NCBI chr10:83,843,948...83,853,063
Ensembl chr10:83,347,731...83,356,775

G

parkin RBR E3 ubiquitin protein ligase

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of PRKN mRNA

NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:48,690,556...49,882,555

G

prostaglandin-endoperoxide synthase 2

multiple interactions

[Linuron binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with Linuron] results in increased expression of RELA protein modified form]; [IL1B protein co-treated with TNF protein co-treated with Linuron] results in increased expression of RELA protein modified form

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484

G

reelin

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of RELN mRNA

NCBI chr 4:13,628,440...14,055,201
Ensembl chr 4:12,736,130...13,162,211

G

roundabout guidance receptor 1

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of ROBO1 mRNA

NCBI chr11:24,067,869...25,108,694
Ensembl chr11:10,580,908...11,620,203

G

ribosomal protein S6 kinase B2

decreases expression

Linuron results in decreased expression of RPS6KB2 mRNA

NCBI chr 1:210,880,824...210,887,556
Ensembl chr 1:201,451,265...201,458,078

G

regulatory associated protein of MTOR, complex 1

decreases expression

Linuron results in decreased expression of RPTOR mRNA

NCBI chr10:105,376,943...105,675,416
Ensembl chr10:104,878,487...105,176,983

G

retinoid X receptor alpha

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of RXRA mRNA

NCBI chr 3:31,387,892...31,474,415
Ensembl chr 3:10,989,832...11,073,712

G

SH3 and multiple ankyrin repeat domains 2

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of SHANK2 mRNA

NCBI chr 1:208,575,144...209,020,300
Ensembl chr 1:199,169,429...199,589,394

G

sex hormone binding globulin

decreases expression

Linuron results in decreased expression of SHBG mRNA

NCBI chr10:54,831,716...54,849,162
Ensembl chr10:54,332,941...54,351,057

G

sigma non-opioid intracellular receptor 1

increases activity
multiple interactions
decreases response to substance

Linuron results in increased activity of SIGMAR1 protein
Linuron promotes the reaction [ERN1 protein binds to SIGMAR1 protein]
SIGMAR1 gene mutant form results in decreased susceptibility to Linuron
SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of ARG1 mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of CCL1 mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of CCL17 mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of CCL20 mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of CCL4 mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of CCR2 mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of CSF2 mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of CXCL10 mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of IFNB1 mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of IFNG mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of IL1B mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of IL21 mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of IL23A mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of IL6 mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of MMP12 mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of NOS2 mRNA]; SIGMAR1 gene promotes the reaction [Linuron results in increased expression of AHR mRNA]; SIGMAR1 gene promotes the reaction [Linuron results in increased expression of CSPG4 mRNA]; SIGMAR1 gene promotes the reaction [Linuron results in increased expression of ENTPD1 mRNA]; SIGMAR1 gene promotes the reaction [Linuron results in increased expression of IFNAR1 mRNA]; SIGMAR1 gene promotes the reaction [Linuron results in increased expression of IL10RA mRNA]; SIGMAR1 gene promotes the reaction [Linuron results in increased expression of LIF mRNA]; SIGMAR1 gene promotes the reaction [Linuron results in increased expression of TGFB2 mRNA]

NCBI chr 5:61,700,021...61,702,799
Ensembl chr 5:56,904,159...56,907,017

G

solute carrier family 1 member 2

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of SLC1A2 mRNA

NCBI chr 3:109,460,109...109,590,445
Ensembl chr 3:89,005,129...89,126,498

G

solute carrier family 1 member 6

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of SLC1A6 mRNA

NCBI chr 7:11,492,422...11,521,007
Ensembl chr 7:10,841,837...10,870,449

G

slit guidance ligand 1

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of SLIT1 mRNA

NCBI chr 1:240,409,559...240,558,127
Ensembl chr 1:240,409,561...240,558,127

G

spectrin, beta, non-erythrocytic 2

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of SPTBN2 mRNA

NCBI chr 1:211,432,373...211,473,016
Ensembl chr 1:202,002,970...202,044,283

G

steroid 5 alpha-reductase 1

decreases expression

Linuron results in decreased expression of SRD5A1 mRNA

NCBI chr 1:35,514,914...35,548,898
Ensembl chr 1:33,686,391...33,720,461

G

steroid 5 alpha-reductase 2

decreases activity

Linuron results in decreased activity of SRD5A2 protein

NCBI chr 6:27,178,089...27,217,588
Ensembl chr 6:21,426,215...21,462,112

G

steroidogenic acute regulatory protein

decreases expression

Linuron results in decreased expression of STAR mRNA

NCBI chr16:72,969,824...72,974,447
Ensembl chr16:66,264,807...66,271,672

G

stathmin 2

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of STMN2 mRNA

NCBI chr 2:95,112,017...95,159,642
Ensembl chr 2:93,204,692...93,252,011

G

steroid sulfatase

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of STS mRNA

NCBI chr X:46,102,524...46,110,868
Ensembl chr X:42,225,372...42,233,402

G

syntaxin binding protein 1

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of STXBP1 mRNA

NCBI chr 3:36,474,428...36,536,120
Ensembl chr 3:16,076,391...16,138,369

G

synaptic Ras GTPase activating protein 1

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of SYNGAP1 mRNA

NCBI chr20:5,028,226...5,058,519
Ensembl chr20:5,026,364...5,056,672

G

synaptophysin

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of SYP mRNA

NCBI chr X:17,521,348...17,536,449
Ensembl chr X:14,849,444...14,864,745

G

trefoil factor 1

increases expression

Linuron results in increased expression of TFF1 mRNA

NCBI chr20:9,237,095...9,240,956
Ensembl chr20:9,235,736...9,239,597

G

transforming growth factor, beta 1

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of TGFB1 mRNA

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor, beta 2

multiple interactions
increases expression

SIGMAR1 gene promotes the reaction [Linuron results in increased expression of TGFB2 mRNA]; XBP1 gene promotes the reaction [Linuron results in increased expression of TGFB2 mRNA]

NCBI chr13:100,691,540...100,793,227
Ensembl chr13:98,160,087...98,261,405

G

transforming growth factor, beta 3

increases expression
multiple interactions

Linuron results in increased expression of TGFB3 mRNA
XBP1 gene promotes the reaction [Linuron results in increased expression of TGFB3 mRNA]

NCBI chr 6:111,435,170...111,457,646
Ensembl chr 6:105,704,236...105,726,564

G

tyrosine hydroxylase

multiple interactions

[Plasticizers co-treated with Fungicides, Industrial co-treated with Linuron co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with Dichlorodiphenyl Dichloroethylene co-treated with butylparaben co-treated with Acetaminophen] results in decreased expression of TH mRNA

NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:198,071,503...198,109,767

G

thyroid hormone receptor alpha

multiple interactions

Linuron binds to and results in increased activity of THRA protein

NCBI chr10:84,198,141...84,225,659
Ensembl chr10:83,700,755...83,729,936

G

TIMP metallopeptidase inhibitor 3

affects expression

Linuron affects the expression of TIMP3 mRNA

NCBI chr 7:19,408,539...19,459,558
Ensembl chr 7:17,521,919...17,571,839

G

toll-like receptor 5

increases expression
multiple interactions

Linuron results in increased expression of TLR5 mRNA
XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of TLR5 mRNA]

NCBI chr13:97,166,430...97,190,642
Ensembl chr13:94,634,801...94,657,738

G

tumor necrosis factor

multiple interactions
increases expression

1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]]; Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]; STF 083010 inhibits the reaction [[Linuron co-treated with IL1B protein co-treated with TNF protein] results in increased splicing of XBP1 mRNA]; STF 083010 inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]]
1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with Linuron] results in increased expression of RELA protein modified form]; 1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with Linuron] results in increased expression of XBP1 protein modified form]; 1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with Linuron] results in increased splicing of XBP1 mRNA]; 1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of CCL2 mRNA]]; 1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of CSF2 mRNA]]; 1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of ERN1 protein modified form]]; 1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of IL6 mRNA]]; 1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]]; [IL1B protein co-treated with TNF protein co-treated with Linuron] promotes the reaction [XBP1 protein binds to NOS2 promoter]; [IL1B protein co-treated with TNF protein co-treated with Linuron] results in increased expression of RELA protein modified form; [IL1B protein co-treated with TNF protein co-treated with Linuron] results in increased expression of XBP1 protein modified form; [IL1B protein co-treated with TNF protein co-treated with Linuron] results in increased splicing of XBP1 mRNA; [IL1B protein co-treated with TNF protein] results in increased susceptibility to Linuron; Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of CCL2 mRNA]; Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of CSF2 mRNA]; Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of IL6 mRNA]; Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]; STF 083010 inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of TNF mRNA]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

G

TSC complex subunit 1

increases expression

Linuron results in increased expression of TSC1 mRNA

NCBI chr 3:32,367,434...32,416,565
Ensembl chr 3:11,979,729...12,015,674

G

TSC complex subunit 2

multiple interactions
increases expression

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of TSC2 mRNA
Linuron results in increased expression of TSC2 mRNA

PMID:25607892 PMID:28705778

NCBI chr10:14,125,679...14,160,317
Ensembl chr10:13,621,136...13,655,951

G

unc-5 netrin receptor B

multiple interactions

[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of UNC5B mRNA

NCBI chr20:29,240,639...29,307,270
Ensembl chr20:28,697,726...28,764,537

G

X-box binding protein 1

decreases response to substance
increases activity
multiple interactions

XBP1 gene mutant form results in decreased susceptibility to Linuron
Linuron results in increased activity of XBP1 protein
1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with Linuron] results in increased expression of XBP1 protein modified form]; 1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with Linuron] results in increased splicing of XBP1 mRNA]; [IL1B protein co-treated with TNF protein co-treated with Linuron] promotes the reaction [XBP1 protein binds to NOS2 promoter]; [IL1B protein co-treated with TNF protein co-treated with Linuron] results in increased expression of XBP1 protein modified form; [IL1B protein co-treated with TNF protein co-treated with Linuron] results in increased splicing of XBP1 mRNA; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of ARG1 mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of CCL1 mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of CCL2 mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of CCL20 mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of CCR2 mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of CSF2 mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of HIF1A mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of IFNG mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of IL13 mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of IL1B mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of IL23A mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of IL5 mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of IL6 mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of MMP12 mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of NOS2 mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of TLR5 mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of TNF mRNA]; XBP1 gene promotes the reaction [Linuron results in increased expression of AHR mRNA]; XBP1 gene promotes the reaction [Linuron results in increased expression of ARNT mRNA]; XBP1 gene promotes the reaction [Linuron results in increased expression of CNTF mRNA]; XBP1 gene promotes the reaction [Linuron results in increased expression of CSPG4 mRNA]; XBP1 gene promotes the reaction [Linuron results in increased expression of CXCL12 mRNA]; XBP1 gene promotes the reaction [Linuron results in increased expression of CYP1B1 mRNA]; XBP1 gene promotes the reaction [Linuron results in increased expression of ENTPD1 mRNA]; XBP1 gene promotes the reaction [Linuron results in increased expression of IFNAR1 mRNA]; XBP1 gene promotes the reaction [Linuron results in increased expression of IL10 mRNA]; XBP1 gene promotes the reaction [Linuron results in increased expression of IRF3 mRNA]; XBP1 gene promotes the reaction [Linuron results in increased expression of IRF7 mRNA]; XBP1 gene promotes the reaction [Linuron results in increased expression of IRF9 mRNA]; XBP1 gene promotes the reaction [Linuron results in increased expression of LIF mRNA]; XBP1 gene promotes the reaction [Linuron results in increased expression of TGFB2 mRNA]; XBP1 gene promotes the reaction [Linuron results in increased expression of TGFB3 mRNA]
STF 083010 inhibits the reaction [[Linuron co-treated with IL1B protein co-treated with TNF protein] results in increased splicing of XBP1 mRNA]

NCBI chr14:84,604,623...84,609,707
Ensembl chr14:80,390,643...80,395,693

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19879
role	19850
application	19693
agrochemical	16873
linuron	193
Path 2
Term	Annotations
CHEBI ontology	19879
subatomic particle	19877
composite particle	19877
hadron	19877
baryon	19877
nucleon	19877
atomic nucleus	19877
atom	19877
main group element atom	19816
p-block element atom	19816
carbon group element atom	19756
carbon atom	19753
organic molecular entity	19753
heteroorganic entity	19521
organochalcogen compound	19281
organooxygen compound	19199
carbon oxoacid	18676
carboxylic acid	18673
carboacyl group	17706
univalent carboacyl group	17706
carbamoyl group	17550
carboxamide	17550
monocarboxylic acid amide	15729
urea	6230
ureas	6228
phenylureas	2626
linuron	193

paths to the root