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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:linuron
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Accession:CHEBI:6482 term browser browse the term
Definition:A member of the class of phenylureas that is N-methyl urea substituted by a methoxy group at position 1 and a 3,4-dichlorophenyl group at position 3.
Synonyms:related_synonym: 1-Methoxy-1-methyl-3-(3,4-dichlorophenyl)urea;   3-(3,4-dichlorophenyl)-1-methoxy-1-methylurea;   Formula=C9H10Cl2N2O2;   InChI=1S/C9H10Cl2N2O2/c1-13(15-2)9(14)12-6-3-4-7(10)8(11)5-6/h3-5H,1-2H3,(H,12,14);   InChIKey=XKJMBINCVNINCA-UHFFFAOYSA-N;   N'-(3,4-dichlorophenyl)-N-methoxy-N-methyl Urea;   SMILES=CON(C)C(=O)Nc1ccc(Cl)c(Cl)c1
 xref: CAS:330-55-2;   KEGG:C11007
 xref_mesh: MESH:D008044
 xref: PMID:23586778;   PMID:24410802;   PMID:25238184;   PPDB:419;   Pesticides:linuron;   Reaxys:2128725


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linuron term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actn1 actinin, alpha 1 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of ACTN1 mRNA CTD PMID:25607892 NCBI chr 6:103,376,557...103,470,497
Ensembl chr 6:103,375,799...103,470,555
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases expression
ISO Linuron binds to and results in increased activity of AHR protein; SIGMAR1 gene promotes the reaction [Linuron results in increased expression of AHR mRNA]; XBP1 gene promotes the reaction [Linuron results in increased expression of AHR mRNA] CTD PMID:18835618 PMID:30661753 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression EXP Linuron results in increased expression of APAF1 mRNA CTD PMID:28705778 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
JBrowse link
G Ar androgen receptor multiple interactions
affects activity
affects binding
decreases expression
decreases activity
increases expression
ISO
EXP
Dihydrotestosterone inhibits the reaction [Linuron results in increased activity of AR protein]; Linuron binds to and results in decreased activity of AR protein; Linuron inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; Linuron inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; Linuron inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; Linuron inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; Linuron inhibits the reaction [Metribolone binds to AR protein]; Linuron inhibits the reaction [Metribolone results in increased activity of AR protein]; Linuron inhibits the reaction [Stanozolol binds to and results in increased activity of AR protein]; Linuron inhibits the reaction [Testosterone results in increased activity of AR protein]; methoxyacetic acid inhibits the reaction [Linuron inhibits the reaction [Testosterone results in increased activity of AR protein]]
Linuron affects the activity of AR protein
Linuron binds to AR protein
Linuron results in decreased expression of AR mRNA
Linuron results in decreased activity of AR protein
Linuron results in increased expression of AR mRNA
Linuron binds to and results in decreased activity of AR protein; Linuron inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; Linuron inhibits the reaction [Metribolone binds to AR protein]
CTD PMID:10910998 PMID:10964759 PMID:11861974 PMID:12730624 PMID:14565775 PMID:14687758 PMID:15064155 PMID:18315717 PMID:18324785 PMID:18486176 PMID:19833195 PMID:20438827 PMID:21251949 PMID:21310686 PMID:26867867 PMID:29162470 PMID:33049310 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Arg1 arginase 1 increases expression
multiple interactions
ISO Linuron results in increased expression of ARG1 mRNA
SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of ARG1 mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of ARG1 mRNA]
CTD PMID:30661753 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO XBP1 gene promotes the reaction [Linuron results in increased expression of ARNT mRNA] CTD PMID:30661753 NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179
JBrowse link
G Bace1 beta-secretase 1 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of BACE1 mRNA CTD PMID:25607892 NCBI chr 8:50,140,092...50,162,388
Ensembl chr 8:50,139,997...50,162,361
JBrowse link
G Bace2 beta-secretase 2 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of BACE2 mRNA CTD PMID:25607892 NCBI chr11:37,798,397...37,880,624
Ensembl chr11:37,798,370...37,880,821
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of BDNF mRNA CTD PMID:25607892 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Becn1 beclin 1 increases expression EXP Linuron results in increased expression of BECN1 mRNA CTD PMID:28705778 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Bmp4 bone morphogenetic protein 4 decreases expression EXP Linuron results in decreased expression of BMP4 mRNA CTD PMID:12730624 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740
JBrowse link
G Bmpr1b bone morphogenetic protein receptor type 1B decreases expression EXP Linuron results in decreased expression of BMPR1B mRNA CTD PMID:12730624 NCBI chr 2:247,392,195...247,662,026
Ensembl chr 2:247,403,920...247,446,882
JBrowse link
G Bsn bassoon (presynaptic cytomatrix protein) multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of BSN mRNA CTD PMID:25607892 NCBI chr 8:116,873,721...116,965,396
Ensembl chr 8:116,873,721...116,965,396
JBrowse link
G Cacna1a calcium voltage-gated channel subunit alpha1 A multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1A mRNA CTD PMID:25607892 NCBI chr19:25,453,236...25,749,550
Ensembl chr19:25,526,751...25,749,550
JBrowse link
G Cacna1b calcium voltage-gated channel subunit alpha1 B multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1B mRNA CTD PMID:25607892 NCBI chr 3:1,740,026...1,924,959
Ensembl chr 3:1,740,024...1,924,827
JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1C mRNA CTD PMID:25607892 NCBI chr 4:150,635,808...151,270,790
Ensembl chr 4:150,641,066...150,829,913
JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1D mRNA CTD PMID:25607892 NCBI chr16:6,110,294...6,405,022
Ensembl chr16:6,112,150...6,405,117
JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNA1G mRNA CTD PMID:25607892 NCBI chr10:82,129,071...82,197,828
Ensembl chr10:82,129,506...82,197,848
JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of CACNA1I mRNA CTD PMID:25607892 NCBI chr 7:121,521,787...121,619,300
Ensembl chr 7:121,511,097...121,619,283
JBrowse link
G Cacna2d3 calcium voltage-gated channel auxiliary subunit alpha2delta 3 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of CACNA2D3 mRNA CTD PMID:25607892 NCBI chr16:4,871,348...5,795,825
Ensembl chr16:4,871,650...5,795,825
JBrowse link
G Cacnb1 calcium voltage-gated channel auxiliary subunit beta 1 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNB1 mRNA CTD PMID:25607892 NCBI chr10:85,954,138...85,974,764
Ensembl chr10:85,954,138...85,974,651
JBrowse link
G Cacnb3 calcium voltage-gated channel auxiliary subunit beta 3 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNB3 mRNA CTD PMID:25607892 NCBI chr 7:140,311,120...140,324,902
Ensembl chr 7:140,315,368...140,324,902
JBrowse link
G Cacng2 calcium voltage-gated channel auxiliary subunit gamma 2 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of CACNG2 mRNA CTD PMID:25607892 NCBI chr 7:119,228,112...119,353,332
Ensembl chr 7:119,228,102...119,352,605
JBrowse link
G Cacng6 calcium voltage-gated channel auxiliary subunit gamma 6 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of CACNG6 mRNA CTD PMID:25607892 NCBI chr 1:64,307,684...64,322,124
Ensembl chr 1:64,305,438...64,321,241
JBrowse link
G Cacng7 calcium voltage-gated channel auxiliary subunit gamma 7 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CACNG7 mRNA CTD PMID:25607892 NCBI chr 1:64,374,547...64,405,380
Ensembl chr 1:64,374,603...64,405,149
JBrowse link
G Cadm1 cell adhesion molecule 1 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of CADM1 mRNA CTD PMID:25607892 NCBI chr 8:51,858,906...52,200,591
Ensembl chr 8:52,127,399...52,189,722
JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CAMK2B mRNA CTD PMID:25607892 NCBI chr14:86,208,876...86,297,727
Ensembl chr14:86,208,901...86,297,652
JBrowse link
G Camk2g calcium/calmodulin-dependent protein kinase II gamma multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of CAMK2G mRNA CTD PMID:25607892 NCBI chr15:3,936,721...3,995,740
Ensembl chr15:3,936,786...3,995,915
Ensembl chr15:3,936,786...3,995,915
JBrowse link
G Casp3 caspase 3 increases expression EXP Linuron results in increased expression of CASP3 mRNA CTD PMID:28705778 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccl1 C-C motif chemokine ligand 1 increases expression
multiple interactions
ISO Linuron results in increased expression of CCL1 mRNA
SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of CCL1 mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of CCL1 mRNA]
CTD PMID:30661753 NCBI chr10:69,534,976...69,537,836
Ensembl chr10:69,534,933...69,537,882
JBrowse link
G Ccl17 C-C motif chemokine ligand 17 multiple interactions
increases expression
ISO SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of CCL17 mRNA] CTD PMID:30661753 NCBI chr19:10,619,220...10,620,671
Ensembl chr19:10,619,220...10,620,671
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
multiple interactions
ISO Linuron results in increased expression of CCL2 mRNA
1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of CCL2 mRNA]]; Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of CCL2 mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of CCL2 mRNA]
CTD PMID:30661753 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression
multiple interactions
ISO Linuron results in increased expression of CCL20 mRNA
SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of CCL20 mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of CCL20 mRNA]
CTD PMID:30661753 NCBI chr 9:88,918,359...88,921,017
Ensembl chr 9:88,918,433...88,921,001
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression
multiple interactions
ISO Linuron results in increased expression of CCL4 mRNA
SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of CCL4 mRNA]
CTD PMID:30661753 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 multiple interactions
increases expression
ISO SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of CCR2 mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of CCR2 mRNA] CTD PMID:30661753
G Cd44 CD44 molecule (Indian blood group) multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of CD44 mRNA CTD PMID:25607892 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cd81 Cd81 molecule multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CD81 mRNA CTD PMID:25607892 NCBI chr 1:216,237,663...216,253,460
Ensembl chr 1:216,237,697...216,253,311
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression EXP Linuron results in decreased expression of CDK2 mRNA CTD PMID:28705778 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression EXP Linuron results in increased expression of CDKN1A mRNA CTD PMID:28705778 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Chga chromogranin A multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CHGA mRNA CTD PMID:25607892 NCBI chr 6:126,434,226...126,445,569
Ensembl chr 6:126,434,226...126,445,568
JBrowse link
G Cntf ciliary neurotrophic factor multiple interactions
increases expression
ISO XBP1 gene promotes the reaction [Linuron results in increased expression of CNTF mRNA] CTD PMID:30661753 NCBI chr 1:229,599,009...229,601,032
Ensembl chr 1:229,599,009...229,601,032
JBrowse link
G Cox7a2 cytochrome c oxidase subunit 7A2 increases expression EXP Linuron results in increased expression of COX7A2 mRNA CTD PMID:28705778 NCBI chr 8:87,209,529...87,213,627
Ensembl chr 8:87,209,530...87,213,627
JBrowse link
G Csf2 colony stimulating factor 2 increases expression
multiple interactions
ISO Linuron results in increased expression of CSF2 mRNA
1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of CSF2 mRNA]]; Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of CSF2 mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of CSF2 mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of CSF2 mRNA]
CTD PMID:30661753 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Cspg4 chondroitin sulfate proteoglycan 4 multiple interactions
increases expression
ISO SIGMAR1 gene promotes the reaction [Linuron results in increased expression of CSPG4 mRNA]; XBP1 gene promotes the reaction [Linuron results in increased expression of CSPG4 mRNA] CTD PMID:30661753 NCBI chr 8:61,532,465...61,567,510
Ensembl chr 8:61,532,465...61,567,510
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression
multiple interactions
ISO Linuron results in increased expression of CXCL10 mRNA
SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of CXCL10 mRNA]
CTD PMID:30661753 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 increases expression
multiple interactions
ISO Linuron results in increased expression of CXCL12 mRNA
XBP1 gene promotes the reaction [Linuron results in increased expression of CXCL12 mRNA]
CTD PMID:30661753 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression EXP Linuron results in decreased expression of CYP11A1 mRNA; Linuron results in decreased expression of CYP11A1 protein CTD PMID:28007637 PMID:28705778 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression EXP Linuron results in decreased expression of CYP17A1 mRNA CTD PMID:28007637 PMID:28705778 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of CYP19A1 mRNA CTD PMID:25607892 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity EXP Linuron results in increased activity of CYP1A1 protein CTD PMID:7823289 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases response to substance ISO CYP1A2 protein results in decreased susceptibility to Linuron CTD PMID:29573710 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression
multiple interactions
ISO Linuron results in increased expression of CYP1B1 mRNA
XBP1 gene promotes the reaction [Linuron results in increased expression of CYP1B1 mRNA]
CTD PMID:16040568 PMID:30661753 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 affects activity EXP Linuron affects the activity of CYP2B1 protein CTD PMID:7823289 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 affects activity EXP Linuron affects the activity of CYP2B2 protein CTD PMID:7823289 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
JBrowse link
G Dcc DCC netrin 1 receptor multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of DCC mRNA CTD PMID:25607892 NCBI chr18:66,518,213...67,629,801
Ensembl chr18:66,523,120...67,224,566
JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of DLG1 mRNA CTD PMID:25607892 NCBI chr11:72,164,566...72,378,895
Ensembl chr11:72,163,749...72,378,895
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of DLG4 mRNA; [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of DLG4 mRNA CTD PMID:25607892 NCBI chr10:56,625,845...56,655,543
Ensembl chr10:56,627,411...56,653,599
JBrowse link
G Dlgap3 DLG associated protein 3 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of DLGAP3 mRNA CTD PMID:25607892 NCBI chr 5:145,234,757...145,304,536
Ensembl chr 5:145,257,714...145,304,536
JBrowse link
G Dlgap4 DLG associated protein 4 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of DLGAP4 mRNA CTD PMID:25607892 NCBI chr 3:152,752,091...152,846,118
Ensembl chr 3:152,752,091...152,846,118
JBrowse link
G Dll1 delta like canonical Notch ligand 1 increases expression EXP Linuron results in increased expression of DLL1 mRNA CTD PMID:12730624 NCBI chr 1:57,318,621...57,326,732
Ensembl chr 1:57,318,708...57,327,379
JBrowse link
G Doc2a double C2 domain alpha multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of DOC2A mRNA CTD PMID:25607892 NCBI chr 1:198,282,828...198,288,611
Ensembl chr 1:198,284,473...198,288,113
JBrowse link
G Dpp10 dipeptidyl peptidase like 10 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of DPP10 mRNA CTD PMID:25607892 NCBI chr13:39,430,590...41,173,706
Ensembl chr13:39,434,217...39,643,361
JBrowse link
G Dpp6 dipeptidyl peptidase like 6 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of DPP6 mRNA CTD PMID:25607892 NCBI chr 4:4,021,021...4,943,675
Ensembl chr 4:4,021,008...4,473,307
JBrowse link
G Dpyd dihydropyrimidine dehydrogenase multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of DPYD mRNA CTD PMID:25607892 NCBI chr 2:221,823,692...222,694,627
Ensembl chr 2:221,823,687...222,694,627
JBrowse link
G Egf epidermal growth factor multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of EGF mRNA CTD PMID:25607892 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor decreases expression
multiple interactions
EXP Linuron results in decreased expression of EGFR mRNA
[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of EGFR mRNA
CTD PMID:12730624 PMID:25607892 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E decreases expression EXP Linuron results in decreased expression of EIF4E mRNA CTD PMID:28705778 NCBI chr 2:243,819,616...243,853,987
Ensembl chr 2:243,820,661...243,852,631
JBrowse link
G Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 increases expression
multiple interactions
ISO Linuron results in increased expression of ENTPD1 mRNA
SIGMAR1 gene promotes the reaction [Linuron results in increased expression of ENTPD1 mRNA]; XBP1 gene promotes the reaction [Linuron results in increased expression of ENTPD1 mRNA]
CTD PMID:30661753 NCBI chr 1:259,692,020...259,818,922
Ensembl chr 1:259,739,955...259,819,494
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of ERBB2 mRNA CTD PMID:25607892 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of ERBB3 mRNA CTD PMID:25607892 NCBI chr 7:2,989,202...3,010,610
Ensembl chr 7:2,989,340...3,010,350
JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of ERBB4 mRNA; [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of ERBB4 mRNA CTD PMID:25607892 NCBI chr 9:75,021,790...76,178,936
Ensembl chr 9:75,021,790...75,528,644
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases activity
multiple interactions
ISO Linuron results in increased activity of ERN1 protein
Linuron promotes the reaction [ERN1 protein binds to SIGMAR1 protein]
1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of ERN1 protein modified form]]
CTD PMID:30661753 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Linuron binds to and results in increased activity of ESR1 protein CTD PMID:33049310 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO Linuron binds to and results in increased activity of ESR2 protein CTD PMID:33049310 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 decreases expression EXP Linuron results in decreased expression of FGFR2 mRNA CTD PMID:12730624 NCBI chr 1:200,590,951...200,696,946
Ensembl chr 1:200,590,953...200,696,928
JBrowse link
G Fmr1 FMRP translational regulator 1 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of FMR1 mRNA CTD PMID:25607892 NCBI chr  X:154,684,924...154,722,369
Ensembl chr  X:154,684,935...154,722,314
JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of FYN mRNA CTD PMID:25607892 NCBI chr20:44,436,354...44,630,316
Ensembl chr20:44,436,403...44,630,317
JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GABRA4 mRNA CTD PMID:25607892 NCBI chr14:39,154,072...39,230,994
Ensembl chr14:39,154,529...39,231,695
JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GABRB1 mRNA CTD PMID:25607892 NCBI chr14:38,631,192...39,112,598
Ensembl chr14:38,643,385...39,112,600
JBrowse link
G Gdnf glial cell derived neurotrophic factor multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GDNF mRNA CTD PMID:25607892 NCBI chr 2:56,884,181...56,912,964
Ensembl chr 2:56,887,987...56,910,238
JBrowse link
G Gls glutaminase multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GLS mRNA CTD PMID:25607892 NCBI chr 9:54,212,622...54,284,879
Ensembl chr 9:54,212,767...54,284,872
JBrowse link
G Gpc1 glypican 1 decreases expression EXP Linuron results in decreased expression of GPC1 mRNA CTD PMID:12730624 NCBI chr 9:99,998,275...100,026,818
Ensembl chr 9:99,998,275...100,026,818
JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GRIA2 mRNA CTD PMID:25607892 NCBI chr 2:179,584,302...179,704,629
Ensembl chr 2:179,584,308...179,704,629
JBrowse link
G Gria4 glutamate ionotropic receptor AMPA type subunit 4 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GRIA4 mRNA CTD PMID:25607892 NCBI chr 8:1,548,145...2,045,874
Ensembl chr 8:1,548,146...2,045,817
JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of GRIK1 mRNA CTD PMID:25607892 NCBI chr11:27,811,954...28,213,940
Ensembl chr11:27,811,957...27,971,359
JBrowse link
G Grik2 glutamate ionotropic receptor kainate type subunit 2 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GRIK2 mRNA CTD PMID:25607892 NCBI chr20:53,791,428...54,517,691
Ensembl chr20:53,789,760...54,517,709
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of GRIN1 mRNA CTD PMID:25607892 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of GRIN2B mRNA CTD PMID:25607892 NCBI chr 4:169,541,620...170,000,216
Ensembl chr 4:169,560,387...169,999,873
JBrowse link
G Grip1 glutamate receptor interacting protein 1 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GRIP1 mRNA CTD PMID:25607892 NCBI chr 7:64,672,723...64,854,939
Ensembl chr 7:64,672,722...64,864,404
JBrowse link
G Hbg1 hemoglobin subunit gamma 1 decreases expression EXP Linuron results in decreased expression of HBG1 mRNA CTD PMID:16498641 NCBI chr 1:168,992,841...168,994,219
Ensembl chr 1:168,992,722...168,994,253
JBrowse link
G Hes6 hes family bHLH transcription factor 6 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of HES6 mRNA CTD PMID:25607892 NCBI chr 9:98,549,698...98,551,438
Ensembl chr 9:98,549,705...98,551,438
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression
multiple interactions
ISO Linuron results in increased expression of HIF1A mRNA
XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of HIF1A mRNA]
CTD PMID:30661753 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 decreases expression EXP Linuron results in decreased expression of HSD17B3 mRNA CTD PMID:28007637 NCBI chr17:1,579,319...1,610,745
Ensembl chr17:1,579,319...1,610,745
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 decreases expression EXP Linuron results in decreased expression of IDI1 mRNA CTD PMID:16498641 NCBI chr17:57,976,266...57,984,036
Ensembl chr17:57,976,268...57,984,036
JBrowse link
G Ifnar1 interferon alpha and beta receptor subunit 1 multiple interactions
increases expression
ISO SIGMAR1 gene promotes the reaction [Linuron results in increased expression of IFNAR1 mRNA]; XBP1 gene promotes the reaction [Linuron results in increased expression of IFNAR1 mRNA] CTD PMID:30661753 NCBI chr11:31,640,407...31,666,839
Ensembl chr11:31,640,407...31,664,061
JBrowse link
G Ifnb1 interferon beta 1 multiple interactions
increases expression
ISO SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of IFNB1 mRNA] CTD PMID:30661753 NCBI chr 5:106,865,192...106,865,746
Ensembl chr 5:106,865,192...106,865,746
JBrowse link
G Ifng interferon gamma increases expression
multiple interactions
ISO Linuron results in increased expression of IFNG mRNA
SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of IFNG mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of IFNG mRNA]
CTD PMID:30661753 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igf1 insulin-like growth factor 1 increases expression EXP Linuron results in increased expression of IGF1 mRNA CTD PMID:12730624 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igf1r insulin-like growth factor 1 receptor decreases expression EXP Linuron results in decreased expression of IGF1R mRNA CTD PMID:12730624 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
JBrowse link
G Igf2r insulin-like growth factor 2 receptor multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of IGF2R mRNA CTD PMID:25607892 NCBI chr 1:48,176,095...48,264,482
Ensembl chr 1:48,176,106...48,264,477
JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 decreases expression EXP Linuron results in decreased expression of IGFBP5 mRNA CTD PMID:12730624 NCBI chr 9:80,154,230...80,166,813
Ensembl chr 9:80,150,211...80,167,033
JBrowse link
G Il10 interleukin 10 increases expression
multiple interactions
ISO Linuron results in increased expression of IL10 mRNA
XBP1 gene promotes the reaction [Linuron results in increased expression of IL10 mRNA]
CTD PMID:30661753 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il10ra interleukin 10 receptor subunit alpha multiple interactions
increases expression
ISO SIGMAR1 gene promotes the reaction [Linuron results in increased expression of IL10RA mRNA] CTD PMID:30661753 NCBI chr 8:49,558,062...49,573,891
Ensembl chr 8:49,560,035...49,573,742
JBrowse link
G Il13 interleukin 13 increases expression
multiple interactions
ISO Linuron results in increased expression of IL13 mRNA
XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of IL13 mRNA]
CTD PMID:30661753 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
ISO 1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with Linuron] results in increased expression of RELA protein modified form]; 1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with Linuron] results in increased expression of XBP1 protein modified form]; 1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with Linuron] results in increased splicing of XBP1 mRNA]; 1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of CCL2 mRNA]]; 1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of CSF2 mRNA]]; 1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of ERN1 protein modified form]]; 1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of IL6 mRNA]]; 1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]]; [IL1B protein co-treated with TNF protein co-treated with Linuron] promotes the reaction [XBP1 protein binds to NOS2 promoter]; [IL1B protein co-treated with TNF protein co-treated with Linuron] results in increased expression of RELA protein modified form; [IL1B protein co-treated with TNF protein co-treated with Linuron] results in increased expression of XBP1 protein modified form; [IL1B protein co-treated with TNF protein co-treated with Linuron] results in increased splicing of XBP1 mRNA; [IL1B protein co-treated with TNF protein] results in increased susceptibility to Linuron; Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of CCL2 mRNA]; Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of CSF2 mRNA]; Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of IL6 mRNA]; Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of IL1B mRNA]; STF 083010 inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of IL1B mRNA]
1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]]; Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]; STF 083010 inhibits the reaction [[Linuron co-treated with IL1B protein co-treated with TNF protein] results in increased splicing of XBP1 mRNA]; STF 083010 inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]]
CTD PMID:30661753 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1rapl1 interleukin 1 receptor accessory protein-like 1 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of IL1RAPL1 mRNA CTD PMID:25607892 NCBI chr  X:55,439,388...57,004,865
Ensembl chr  X:55,439,578...56,765,893
JBrowse link
G Il21 interleukin 21 increases expression
multiple interactions
ISO Linuron results in increased expression of IL21 mRNA
SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of IL21 mRNA]
CTD PMID:30661753 NCBI chr 2:123,965,021...123,972,356
Ensembl chr 2:123,965,021...123,972,356
JBrowse link
G Il23a interleukin 23 subunit alpha increases expression
multiple interactions
ISO Linuron results in increased expression of IL23A mRNA
SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of IL23A mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of IL23A mRNA]
CTD PMID:30661753 NCBI chr 7:2,710,609...2,712,723
Ensembl chr 7:2,710,609...2,712,723
JBrowse link
G Il5 interleukin 5 increases expression
multiple interactions
ISO Linuron results in increased expression of IL5 mRNA
XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of IL5 mRNA]
CTD PMID:30661753 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO 1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of IL6 mRNA]]; Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of IL6 mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of IL6 mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of IL6 mRNA] CTD PMID:30661753 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Irf3 interferon regulatory factor 3 increases expression
multiple interactions
ISO Linuron results in increased expression of IRF3 mRNA
XBP1 gene promotes the reaction [Linuron results in increased expression of IRF3 mRNA]
CTD PMID:30661753 NCBI chr 1:100,992,244...100,997,202
Ensembl chr 1:100,992,405...100,997,198
JBrowse link
G Irf7 interferon regulatory factor 7 increases expression
multiple interactions
ISO Linuron results in increased expression of IRF7 mRNA
XBP1 gene promotes the reaction [Linuron results in increased expression of IRF7 mRNA]
CTD PMID:30661753 NCBI chr 1:214,249,388...214,252,909
Ensembl chr 1:214,248,837...214,252,456
JBrowse link
G Irf9 interferon regulatory factor 9 increases expression
multiple interactions
ISO Linuron results in increased expression of IRF9 mRNA
XBP1 gene promotes the reaction [Linuron results in increased expression of IRF9 mRNA]
CTD PMID:30661753 NCBI chr15:34,282,936...34,288,981
Ensembl chr15:34,282,936...34,288,138
JBrowse link
G Lif LIF, interleukin 6 family cytokine increases expression
multiple interactions
ISO Linuron results in increased expression of LIF mRNA
SIGMAR1 gene promotes the reaction [Linuron results in increased expression of LIF mRNA]; XBP1 gene promotes the reaction [Linuron results in increased expression of LIF mRNA]
CTD PMID:30661753 NCBI chr14:84,482,652...84,500,574
Ensembl chr14:84,482,674...84,500,642
JBrowse link
G Lrrc7 leucine rich repeat containing 7 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of LRRC7 mRNA CTD PMID:25607892 NCBI chr 2:264,910,594...265,300,860
Ensembl chr 2:264,910,594...265,300,868
JBrowse link
G Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of MAGI2 mRNA CTD PMID:25607892 NCBI chr 4:10,995,241...12,472,423
Ensembl chr 4:10,995,234...11,610,518
JBrowse link
G Mdga2 MAM domain containing glycosylphosphatidylinositol anchor 2 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of MDGA2 mRNA CTD PMID:25607892 NCBI chr 6:88,442,620...89,292,454
Ensembl chr 6:88,447,749...88,917,070
JBrowse link
G Mfn2 mitofusin 2 decreases expression EXP Linuron results in decreased expression of MFN2 mRNA CTD PMID:28705778 NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
JBrowse link
G Mmp12 matrix metallopeptidase 12 increases expression
multiple interactions
ISO Linuron results in increased expression of MMP12 mRNA
SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of MMP12 mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of MMP12 mRNA]
CTD PMID:30661753 NCBI chr 8:5,594,717...5,616,494
Ensembl chr 8:5,606,592...5,616,493
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression EXP Linuron results in decreased expression of MYC mRNA CTD PMID:28705778 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Myom2 myomesin 2 increases expression EXP Linuron results in increased expression of MYOM2 mRNA CTD PMID:16498641 NCBI chr16:79,587,136...79,672,871
Ensembl chr16:79,587,640...79,671,719
JBrowse link
G Nf1 neurofibromin 1 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NF1 mRNA CTD PMID:25607892 NCBI chr10:66,732,460...66,928,706
Ensembl chr10:66,690,133...66,928,903
JBrowse link
G Nlgn1 neuroligin 1 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NLGN1 mRNA CTD PMID:25607892 NCBI chr 2:111,057,291...111,973,681
Ensembl chr 2:111,057,291...111,793,326
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
ISO Linuron results in increased expression of NOS2 mRNA
1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]]; Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]; STF 083010 inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]]
1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]]; [IL1B protein co-treated with TNF protein co-treated with Linuron] promotes the reaction [XBP1 protein binds to NOS2 promoter]; Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of NOS2 mRNA]; STF 083010 inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of NOS2 mRNA]
CTD PMID:30661753 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Notch2 notch receptor 2 decreases expression
multiple interactions
EXP Linuron results in decreased expression of NOTCH2 mRNA
[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of NOTCH2 mRNA
CTD PMID:12730624 PMID:25607892 NCBI chr 2:200,187,184...200,320,403
Ensembl chr 2:200,187,179...200,320,215
JBrowse link
G Notch3 notch receptor 3 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of NOTCH3 mRNA CTD PMID:25607892 NCBI chr 7:14,138,495...14,189,688
Ensembl chr 7:14,138,495...14,189,688
JBrowse link
G Notch4 notch receptor 4 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NOTCH4 mRNA CTD PMID:25607892 NCBI chr20:4,329,794...4,353,868
Ensembl chr20:4,329,811...4,353,785
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Linuron binds to and results in increased activity of NR1I2 protein
[Chlorfenvinphos co-treated with ethion co-treated with Linuron] results in increased activity of NR1I2 protein; Linuron binds to and results in increased activity of NR1I2 protein
CTD PMID:21115097 PMID:25028461 PMID:33049310 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nrcam neuronal cell adhesion molecule multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of NRCAM mRNA CTD PMID:25607892 NCBI chr 6:64,297,843...64,867,408
Ensembl chr 6:64,297,888...64,864,996
JBrowse link
G Nrg1 neuregulin 1 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NRG1 mRNA; [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of NRG1 mRNA CTD PMID:25607892 NCBI chr16:62,969,573...64,065,063
Ensembl chr16:63,837,216...64,057,434
JBrowse link
G Nrxn1 neurexin 1 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of NRXN1 mRNA CTD PMID:25607892 NCBI chr 6:13,886,757...15,191,660
Ensembl chr 6:13,886,740...15,191,660
JBrowse link
G Nrxn2 neurexin 2 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NRXN2 mRNA CTD PMID:25607892 NCBI chr 1:221,792,191...221,908,047
Ensembl chr 1:221,792,221...221,908,049
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NTRK2 mRNA CTD PMID:25607892 NCBI chr17:5,934,651...6,245,778
Ensembl chr17:5,933,729...6,244,676
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression EXP Linuron results in decreased expression of PCNA mRNA; Linuron results in decreased expression of PCNA protein CTD PMID:28007637 PMID:28705778 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pgr progesterone receptor multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of PGR mRNA CTD PMID:25607892 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO Linuron binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of PRKN mRNA CTD PMID:25607892 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Linuron binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2 CTD PMID:26359731 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO 1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with Linuron] results in increased expression of RELA protein modified form]; [IL1B protein co-treated with TNF protein co-treated with Linuron] results in increased expression of RELA protein modified form CTD PMID:30661753 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Reln reelin multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of RELN mRNA CTD PMID:25607892 NCBI chr 4:9,347,533...9,774,257
Ensembl chr 4:9,347,528...9,773,670
JBrowse link
G Robo1 roundabout guidance receptor 1 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of ROBO1 mRNA CTD PMID:25607892 NCBI chr11:9,079,291...10,146,302
Ensembl chr11:9,642,365...10,143,317
JBrowse link
G Rps6kb2 ribosomal protein S6 kinase B2 decreases expression EXP Linuron results in decreased expression of RPS6KB2 mRNA CTD PMID:28705778 NCBI chr 1:219,406,201...219,412,888
Ensembl chr 1:219,406,202...219,412,888
JBrowse link
G Rptor regulatory associated protein of MTOR, complex 1 decreases expression EXP Linuron results in decreased expression of RPTOR mRNA CTD PMID:28705778 NCBI chr10:108,750,620...109,058,691
Ensembl chr10:108,750,620...109,058,691
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of RXRA mRNA CTD PMID:25607892 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Shank2 SH3 and multiple ankyrin repeat domains 2 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of SHANK2 mRNA CTD PMID:25607892 NCBI chr 1:217,149,156...217,593,950
Ensembl chr 1:217,151,166...217,592,763
JBrowse link
G Shbg sex hormone binding globulin decreases expression EXP Linuron results in decreased expression of SHBG mRNA CTD PMID:28705778 NCBI chr10:56,219,861...56,237,354
Ensembl chr10:56,219,858...56,223,245
JBrowse link
G Sigmar1 sigma non-opioid intracellular receptor 1 increases activity
multiple interactions
decreases response to substance
ISO Linuron results in increased activity of SIGMAR1 protein
SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of ARG1 mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of CCL1 mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of CCL17 mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of CCL20 mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of CCL4 mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of CCR2 mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of CSF2 mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of CXCL10 mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of IFNB1 mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of IFNG mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of IL1B mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of IL21 mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of IL23A mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of IL6 mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of MMP12 mRNA]; SIGMAR1 gene mutant form inhibits the reaction [Linuron results in increased expression of NOS2 mRNA]; SIGMAR1 gene promotes the reaction [Linuron results in increased expression of AHR mRNA]; SIGMAR1 gene promotes the reaction [Linuron results in increased expression of CSPG4 mRNA]; SIGMAR1 gene promotes the reaction [Linuron results in increased expression of ENTPD1 mRNA]; SIGMAR1 gene promotes the reaction [Linuron results in increased expression of IFNAR1 mRNA]; SIGMAR1 gene promotes the reaction [Linuron results in increased expression of IL10RA mRNA]; SIGMAR1 gene promotes the reaction [Linuron results in increased expression of LIF mRNA]; SIGMAR1 gene promotes the reaction [Linuron results in increased expression of TGFB2 mRNA]
SIGMAR1 gene mutant form results in decreased susceptibility to Linuron
Linuron promotes the reaction [ERN1 protein binds to SIGMAR1 protein]
CTD PMID:30661753 NCBI chr 5:58,121,824...58,124,687
Ensembl chr 5:58,121,786...58,124,681
JBrowse link
G Slc1a2 solute carrier family 1 member 2 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of SLC1A2 mRNA CTD PMID:25607892 NCBI chr 3:92,518,679...92,665,731
Ensembl chr 3:92,640,752...92,665,644
JBrowse link
G Slc1a6 solute carrier family 1 member 6 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of SLC1A6 mRNA CTD PMID:25607892 NCBI chr 7:13,730,101...13,758,170
Ensembl chr 7:13,730,253...13,751,271
JBrowse link
G Slit1 slit guidance ligand 1 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of SLIT1 mRNA CTD PMID:25607892 NCBI chr 1:260,843,481...260,992,366
Ensembl chr 1:260,843,483...260,992,366
JBrowse link
G Sptbn2 spectrin, beta, non-erythrocytic 2 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of SPTBN2 mRNA CTD PMID:25607892 NCBI chr 1:219,964,429...220,006,811
Ensembl chr 1:219,964,429...220,005,068
JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 decreases expression EXP Linuron results in decreased expression of SRD5A1 mRNA CTD PMID:28705778 NCBI chr 1:36,320,504...36,354,694
Ensembl chr 1:36,320,461...36,354,756
JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 decreases activity ISO Linuron results in decreased activity of SRD5A2 protein CTD PMID:17218080 NCBI chr 6:25,279,635...25,315,501
Ensembl chr 6:25,279,626...25,315,511
JBrowse link
G Star steroidogenic acute regulatory protein decreases expression EXP Linuron results in decreased expression of STAR mRNA CTD PMID:28705778 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Stmn2 stathmin 2 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of STMN2 mRNA CTD PMID:25607892 NCBI chr 2:95,424,251...95,471,900
Ensembl chr 2:95,424,251...95,472,115
JBrowse link
G Sts steroid sulfatase multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of STS mRNA CTD PMID:25607892 NCBI chr  X:45,420,418...45,428,748
Ensembl chr  X:45,420,596...45,428,750
JBrowse link
G Stxbp1 syntaxin binding protein 1 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of STXBP1 mRNA CTD PMID:25607892 NCBI chr 3:11,823,779...11,885,479
Ensembl chr 3:11,823,785...11,885,417
JBrowse link
G Syngap1 synaptic Ras GTPase activating protein 1 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of SYNGAP1 mRNA CTD PMID:25607892 NCBI chr20:5,535,434...5,564,657
Ensembl chr20:5,535,432...5,564,437
JBrowse link
G Syp synaptophysin multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of SYP mRNA CTD PMID:25607892 NCBI chr  X:15,694,699...15,709,244
Ensembl chr  X:15,695,566...15,707,436
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of TGFB1 mRNA CTD PMID:25607892 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfb2 transforming growth factor, beta 2 multiple interactions
increases expression
ISO SIGMAR1 gene promotes the reaction [Linuron results in increased expression of TGFB2 mRNA]; XBP1 gene promotes the reaction [Linuron results in increased expression of TGFB2 mRNA] CTD PMID:30661753 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Tgfb3 transforming growth factor, beta 3 increases expression
multiple interactions
ISO Linuron results in increased expression of TGFB3 mRNA
XBP1 gene promotes the reaction [Linuron results in increased expression of TGFB3 mRNA]
CTD PMID:30661753 NCBI chr 6:109,913,757...109,936,217
Ensembl chr 6:109,913,757...109,935,533
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Linuron binds to and results in increased activity of THRA protein CTD PMID:33049310 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 affects expression EXP Linuron affects the expression of TIMP3 mRNA CTD PMID:12730624 NCBI chr 7:23,543,125...23,594,170
Ensembl chr 7:23,544,215...23,594,133
JBrowse link
G Tlr5 toll-like receptor 5 increases expression
multiple interactions
ISO Linuron results in increased expression of TLR5 mRNA
XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of TLR5 mRNA]
CTD PMID:30661753 NCBI chr13:101,364,784...101,385,764
Ensembl chr13:101,381,510...101,385,764
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO 1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]]; Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]; STF 083010 inhibits the reaction [[Linuron co-treated with IL1B protein co-treated with TNF protein] results in increased splicing of XBP1 mRNA]; STF 083010 inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]]
Linuron results in increased expression of TNF mRNA
1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with Linuron] results in increased expression of RELA protein modified form]; 1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with Linuron] results in increased expression of XBP1 protein modified form]; 1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with Linuron] results in increased splicing of XBP1 mRNA]; 1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of CCL2 mRNA]]; 1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of CSF2 mRNA]]; 1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of ERN1 protein modified form]]; 1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of IL6 mRNA]]; 1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]]; [IL1B protein co-treated with TNF protein co-treated with Linuron] promotes the reaction [XBP1 protein binds to NOS2 promoter]; [IL1B protein co-treated with TNF protein co-treated with Linuron] results in increased expression of RELA protein modified form; [IL1B protein co-treated with TNF protein co-treated with Linuron] results in increased expression of XBP1 protein modified form; [IL1B protein co-treated with TNF protein co-treated with Linuron] results in increased splicing of XBP1 mRNA; [IL1B protein co-treated with TNF protein] results in increased susceptibility to Linuron; Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of CCL2 mRNA]; Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of CSF2 mRNA]; Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of IL6 mRNA]; Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]; STF 083010 inhibits the reaction [Linuron promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of TNF mRNA]
CTD PMID:30661753 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tsc1 TSC complex subunit 1 increases expression EXP Linuron results in increased expression of TSC1 mRNA CTD PMID:28705778 NCBI chr 3:7,219,955...7,269,063
Ensembl chr 3:7,237,192...7,265,145
JBrowse link
G Tsc2 TSC complex subunit 2 multiple interactions
increases expression
EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of TSC2 mRNA
Linuron results in increased expression of TSC2 mRNA
CTD PMID:25607892 PMID:28705778 NCBI chr10:13,962,006...13,996,684
Ensembl chr10:13,961,947...13,996,584
JBrowse link
G Unc5b unc-5 netrin receptor B multiple interactions EXP [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of UNC5B mRNA CTD PMID:25607892 NCBI chr20:30,339,680...30,406,593
Ensembl chr20:30,339,673...30,406,295
JBrowse link
G Xbp1 X-box binding protein 1 decreases response to substance
multiple interactions
increases activity
ISO XBP1 gene mutant form results in decreased susceptibility to Linuron
STF 083010 inhibits the reaction [[Linuron co-treated with IL1B protein co-treated with TNF protein] results in increased splicing of XBP1 mRNA]
1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with Linuron] results in increased expression of XBP1 protein modified form]; 1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with Linuron] results in increased splicing of XBP1 mRNA]; [IL1B protein co-treated with TNF protein co-treated with Linuron] promotes the reaction [XBP1 protein binds to NOS2 promoter]; [IL1B protein co-treated with TNF protein co-treated with Linuron] results in increased expression of XBP1 protein modified form; [IL1B protein co-treated with TNF protein co-treated with Linuron] results in increased splicing of XBP1 mRNA; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of ARG1 mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of CCL1 mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of CCL2 mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of CCL20 mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of CCR2 mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of CSF2 mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of HIF1A mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of IFNG mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of IL13 mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of IL1B mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of IL23A mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of IL5 mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of IL6 mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of MMP12 mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of NOS2 mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of TLR5 mRNA]; XBP1 gene mutant form inhibits the reaction [Linuron results in increased expression of TNF mRNA]; XBP1 gene promotes the reaction [Linuron results in increased expression of AHR mRNA]; XBP1 gene promotes the reaction [Linuron results in increased expression of ARNT mRNA]; XBP1 gene promotes the reaction [Linuron results in increased expression of CNTF mRNA]; XBP1 gene promotes the reaction [Linuron results in increased expression of CSPG4 mRNA]; XBP1 gene promotes the reaction [Linuron results in increased expression of CXCL12 mRNA]; XBP1 gene promotes the reaction [Linuron results in increased expression of CYP1B1 mRNA]; XBP1 gene promotes the reaction [Linuron results in increased expression of ENTPD1 mRNA]; XBP1 gene promotes the reaction [Linuron results in increased expression of IFNAR1 mRNA]; XBP1 gene promotes the reaction [Linuron results in increased expression of IL10 mRNA]; XBP1 gene promotes the reaction [Linuron results in increased expression of IRF3 mRNA]; XBP1 gene promotes the reaction [Linuron results in increased expression of IRF7 mRNA]; XBP1 gene promotes the reaction [Linuron results in increased expression of IRF9 mRNA]; XBP1 gene promotes the reaction [Linuron results in increased expression of LIF mRNA]; XBP1 gene promotes the reaction [Linuron results in increased expression of TGFB2 mRNA]; XBP1 gene promotes the reaction [Linuron results in increased expression of TGFB3 mRNA]
Linuron results in increased activity of XBP1 protein
CTD PMID:30661753 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link

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  CHEBI ontology 19781
    role 19726
      application 19412
        agrochemical 14699
          linuron 170
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  CHEBI ontology 19781
    subatomic particle 19779
      composite particle 19779
        hadron 19779
          baryon 19779
            nucleon 19779
              atomic nucleus 19779
                atom 19779
                  main group element atom 19669
                    p-block element atom 19669
                      carbon group element atom 19588
                        carbon atom 19578
                          organic molecular entity 19578
                            organic group 18620
                              organic divalent group 18611
                                organodiyl group 18611
                                  carbonyl group 18526
                                    carbonyl compound 18526
                                      carboxylic acid 18202
                                        carboacyl group 17418
                                          univalent carboacyl group 17418
                                            carbamoyl group 17216
                                              carboxamide 17216
                                                monocarboxylic acid amide 14629
                                                  urea 5098
                                                    ureas 5096
                                                      phenylureas 2023
                                                        linuron 170
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