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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sesquarterpene
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Accession:CHEBI:64804 term browser browse the term
Definition:Any terpene having a 35-carbon skeleton.
Synonyms:related_synonym: C35 terpene;   C35 terpenes;   sesquarterpenes
 xref: PMID:20672281;   PMID:21627333



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hyperforin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions
increases expression
EXP hyperforin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]
hyperforin results in increased expression of ABCB1; hyperforin results in increased expression of ABCB1 mRNA
CTD PMID:15266218 PMID:16005588 PMID:24259679 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ALAS1 5'-aminolevulinate synthase 1 increases expression EXP hyperforin results in increased expression of ALAS1 mRNA CTD PMID:24259679 NCBI chr 3:52,198,083...52,214,327
Ensembl chr 3:52,198,086...52,214,327
JBrowse link
G BAK1 BCL2 antagonist/killer 1 increases expression EXP hyperforin results in increased expression of BAK1 protein CTD PMID:32485087 NCBI chr 6:33,572,552...33,580,296
Ensembl chr 6:33,572,547...33,580,293
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions
increases expression
decreases expression
EXP
ISO
hyperforin inhibits the reaction [aluminum maltolate results in increased expression of BAX mRNA]
hyperforin results in increased expression of BAX protein
hyperforin results in decreased expression of BAX mRNA
CTD PMID:30481499 PMID:32485087 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions
increases expression
ISO
EXP
hyperforin inhibits the reaction [aluminum maltolate results in decreased expression of BCL2 mRNA]
hyperforin results in increased expression of BCL2 mRNA
CTD PMID:30481499 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G CASP3 caspase 3 multiple interactions
increases cleavage
decreases expression
ISO
EXP
hyperforin inhibits the reaction [aluminum maltolate results in increased activity of CASP3 protein]; hyperforin inhibits the reaction [aluminum maltolate results in increased expression of CASP3 mRNA]
hyperforin results in increased cleavage of CASP3 protein
hyperforin results in decreased expression of CASP3 mRNA
CTD PMID:30481499 PMID:32485087 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP8 caspase 8 increases cleavage EXP hyperforin results in increased cleavage of CASP8 protein CTD PMID:32485087 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,287,711
JBrowse link
G CCND1 cyclin D1 decreases expression EXP hyperforin results in decreased expression of CCND1 protein CTD PMID:32485087 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator decreases expression EXP hyperforin results in decreased expression of CFLAR protein CTD PMID:32485087 NCBI chr 2:201,116,164...201,176,687
Ensembl chr 2:201,116,154...201,176,687
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions
increases secretion
increases expression
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [hyperforin results in increased expression of CXCL8 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [hyperforin results in increased secretion of CXCL8 protein]; hyperforin promotes the reaction [JUN protein binds to CXCL8 promoter]; SB 203580 inhibits the reaction [hyperforin results in increased secretion of CXCL8 protein]; U 0126 inhibits the reaction [hyperforin results in increased expression of CXCL8 mRNA]; U 0126 inhibits the reaction [hyperforin results in increased secretion of CXCL8 protein] CTD PMID:15622447 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CYCS cytochrome c, somatic decreases expression
multiple interactions
ISO
EXP
hyperforin results in decreased expression of CYCS protein
hyperforin inhibits the reaction [aluminum maltolate results in increased expression of CYCS protein]
CTD PMID:30481499 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions
decreases activity
EXP hyperforin inhibits the reaction [CYP1A1 protein affects the metabolism of benzo(a)pyrene 7,8-dihydrodiol]
hyperforin results in decreased activity of CYP1A1 protein
CTD PMID:14633740 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP24A1 cytochrome P450 family 24 subfamily A member 1 increases expression EXP hyperforin results in increased expression of CYP24A1 mRNA CTD PMID:15630458 NCBI chr20:54,145,731...54,174,032
Ensembl chr20:54,153,446...54,173,986
JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 increases expression EXP hyperforin results in increased expression of CYP2B6 mRNA CTD PMID:24259679 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398
JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 multiple interactions
increases expression
EXP hyperforin results in increased expression of and results in increased activity of CYP2C9 protein; NR1I2 protein affects the reaction [hyperforin results in increased expression of CYP2C9 mRNA] CTD PMID:14600250 PMID:15100173 PMID:24259679 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 decreases activity
increases expression
multiple interactions
EXP hyperforin results in decreased activity of CYP3A4 protein
hyperforin results in increased expression of CYP3A4; hyperforin results in increased expression of CYP3A4 mRNA
hyperforin results in increased expression of and results in increased activity of CYP3A4 protein
CTD PMID:15100173 PMID:15266218 PMID:16005588 PMID:16442130 PMID:17954527 More... NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 increases expression EXP hyperforin results in increased expression of CYP3A5 mRNA CTD PMID:24259679 NCBI chr 7:99,648,194...99,679,996
Ensembl chr 7:99,648,194...99,679,998
JBrowse link
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 decreases expression EXP hyperforin results in decreased expression of CYP7A1 mRNA CTD PMID:24259679 NCBI chr 8:58,490,178...58,500,163
Ensembl chr 8:58,490,178...58,500,163
JBrowse link
G EGFR epidermal growth factor receptor decreases phosphorylation EXP hyperforin results in decreased phosphorylation of EGFR protein CTD PMID:32485087 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628
JBrowse link
G FAS Fas cell surface death receptor increases expression EXP hyperforin results in increased expression of FAS protein CTD PMID:32485087 NCBI chr10:88,968,429...89,017,059
Ensembl chr10:88,990,531...89,017,059
JBrowse link
G FASLG Fas ligand increases expression EXP hyperforin results in increased expression of FASLG protein CTD PMID:32485087 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876
JBrowse link
G ICAM1 intercellular adhesion molecule 1 increases expression EXP hyperforin results in increased expression of ICAM1 mRNA CTD PMID:15622447 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP hyperforin promotes the reaction [JUN protein binds to CXCL8 promoter] CTD PMID:15622447 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation
decreases phosphorylation
EXP hyperforin results in increased phosphorylation of MAPK1 protein
hyperforin results in decreased phosphorylation of MAPK1 protein
CTD PMID:15622447 PMID:32485087 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation
decreases phosphorylation
EXP hyperforin results in increased phosphorylation of MAPK3 protein
hyperforin results in decreased phosphorylation of MAPK3 protein
CTD PMID:15622447 PMID:32485087 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MCL1 MCL1 apoptosis regulator, BCL2 family member decreases expression EXP hyperforin results in decreased expression of MCL1 protein CTD PMID:32485087 NCBI chr 1:150,574,558...150,579,610
Ensembl chr 1:150,560,895...150,579,738
JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 multiple interactions
increases response to substance
affects binding
increases activity
EXP [NR1I2 protein co-treated with hyperforin] results in decreased expression of SLC22A1 mRNA; [NR1I2 protein results in increased susceptibility to hyperforin] which results in decreased expression of SLC22A1 mRNA; hyperforin binds to and results in increased activity of NR1I2 protein; hyperforin promotes the reaction [NR1I2 protein results in decreased expression of SLC22A1 mRNA]; NR1I2 protein affects the reaction [hyperforin results in increased expression of CYP2C9 mRNA]; NR1I2 protein promotes the reaction [hyperforin results in increased abundance of Lipids]
hyperforin binds to NR1I2 protein
hyperforin results in increased activity of NR1I2 protein
CTD PMID:14600250 PMID:15630458 PMID:15856409 PMID:20079722 PMID:26187274 More... NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487
JBrowse link
G POR cytochrome p450 oxidoreductase increases expression EXP hyperforin results in increased expression of POR mRNA CTD PMID:24259679 NCBI chr 7:75,915,155...75,986,855
Ensembl chr 7:75,899,200...75,986,855
JBrowse link
G SLC22A1 solute carrier family 22 member 1 decreases expression
multiple interactions
EXP hyperforin results in decreased expression of SLC22A1 protein
[NR1I2 protein co-treated with hyperforin] results in decreased expression of SLC22A1 mRNA; [NR1I2 protein results in increased susceptibility to hyperforin] which results in decreased expression of SLC22A1 mRNA; hyperforin promotes the reaction [NR1I2 protein results in decreased expression of SLC22A1 mRNA]
CTD PMID:26920453 NCBI chr 6:160,121,808...160,160,590
Ensembl chr 6:160,121,815...160,158,718
JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 increases expression EXP hyperforin results in increased expression of UGT1A1 mRNA CTD PMID:24259679 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300
JBrowse link
G XIAP X-linked inhibitor of apoptosis decreases expression EXP hyperforin results in decreased expression of XIAP protein CTD PMID:32485087 NCBI chr  X:123,859,708...123,913,972
Ensembl chr  X:123,859,724...123,913,976
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 25189
    chemical entity 25160
      atom 25151
        nonmetal atom 24676
          carbon atom 24571
            organic molecular entity 24571
              isoprenoid 13219
                terpene 13219
                  sesquarterpene 31
                    (R)-tetraprenyl-beta-curcumene 0
                    beta-heptaprene 0
                    sesquarterpenoid + 31
Path 2
Term Annotations click to browse term
  CHEBI ontology 25189
    subatomic particle 25151
      composite particle 25151
        hadron 25151
          baryon 25151
            nucleon 25151
              atomic nucleus 25151
                atom 25151
                  main group element atom 25031
                    main group molecular entity 25031
                      s-block molecular entity 24299
                        hydrogen molecular entity 23888
                          hydrides 22147
                            organic hydride 21493
                              organic fundamental parent 21493
                                hydrocarbon 21136
                                  terpene 13219
                                    sesquarterpene 31
                                      (R)-tetraprenyl-beta-curcumene 0
                                      beta-heptaprene 0
                                      sesquarterpenoid + 31
paths to the root