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ONTOLOGY REPORT - ANNOTATIONS


Term:EC 3.1.4.11 (phosphoinositide phospholipase C) inhibitor
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Accession:CHEBI:64763 term browser browse the term
Definition:An EC 3.1.4.* (phosphoric diester hydrolase) inhibitor that interferes with the action of phosphatidylinositol-specific phospholipase C (EC 3.1.4.11).
Synonyms:related_synonym: 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase inhibitor;   1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase inhibitors;   1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase inhibitor;   1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase inhibitors;   1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase inhibitor;   1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase inhibitors;   EC 3.1.4.11 inhibitor;   EC 3.1.4.11 inhibitors;   PI-PLC inhibitor;   PI-PLC inhibitors;   monophosphatidylinositol phosphodiesterase inhibitor;   monophosphatidylinositol phosphodiesterase inhibitors;   phosphatidylinositol phospholipase C inhibitor;   phosphatidylinositol phospholipase C inhibitors;   phosphatidylinositol-specific phospholipase C inhibitor;   phosphatidylinositol-specific phospholipase C inhibitors;   phosphoinositidase C inhibitor;   phosphoinositidase C inhibitors;   phosphoinositide phospholipase C (EC 3.1.4.11) inhibitors;   phosphoinositide phospholipase C inhibitor;   phosphoinositide phospholipase C inhibitors;   triphosphoinositide phosphodiesterase inhibitor;   triphosphoinositide phosphodiesterase inhibitors
 xref: Wikipedia:Phosphatidylinositol-specific_phospholipase_C


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1D-myo-inositol 1-phosphate term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ppargc1a PPARG coactivator 1 alpha JBrowse link 14 63,095,291 63,190,688 RGD:6480464
1D-myo-inositol 6-phosphate term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ppargc1a PPARG coactivator 1 alpha JBrowse link 14 63,095,291 63,190,688 RGD:6480464
U-73122 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adra1a adrenoceptor alpha 1A JBrowse link 15 43,296,997 43,398,314 RGD:6480464
G Adra2a adrenoceptor alpha 2A JBrowse link 1 274,766,283 274,769,083 RGD:6480464
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:6480464
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Apoa1 apolipoprotein A1 JBrowse link 8 50,525,091 50,526,875 RGD:6480464
G Cacna1e calcium voltage-gated channel subunit alpha1 E JBrowse link 13 71,899,445 72,534,992 RGD:6480464
G Camk2a calcium/calmodulin-dependent protein kinase II alpha JBrowse link 18 56,193,978 56,295,869 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casr calcium-sensing receptor JBrowse link 11 67,188,204 67,262,261 RGD:6480464
G Cck cholecystokinin JBrowse link 8 130,120,525 130,127,515 RGD:6480464
G Cd40 CD40 molecule JBrowse link 3 161,519,789 161,534,943 RGD:6480464
G Chrm1 cholinergic receptor, muscarinic 1 JBrowse link 1 224,869,087 224,885,101 RGD:6480464
G Creb1 cAMP responsive element binding protein 1 JBrowse link 9 71,229,753 71,298,994 RGD:6480464
G Csf2 colony stimulating factor 2 JBrowse link 10 39,602,089 39,604,070 RGD:6480464
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 JBrowse link 8 58,744,849 58,772,408 RGD:6480464
G Drd3 dopamine receptor D3 JBrowse link 11 61,819,102 61,883,223 RGD:6480464
G Edn1 endothelin 1 JBrowse link 17 22,136,814 22,143,745 RGD:6480464
G Edn3 endothelin 3 JBrowse link 3 172,856,730 172,879,276 RGD:6480464
G Ednrb endothelin receptor type B JBrowse link 15 88,004,775 88,036,354 RGD:6480464
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:6480464
G F2 coagulation factor II JBrowse link 3 80,529,468 80,542,993 RGD:6480464
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6480464
G Gcg glucagon JBrowse link 3 48,442,635 48,451,650 RGD:6480464
G Gfap glial fibrillary acidic protein JBrowse link 10 90,990,762 90,999,435 RGD:6480464
G Gnas GNAS complex locus JBrowse link 3 172,374,957 172,434,988 RGD:6480464
G Gpbar1 G protein-coupled bile acid receptor 1 JBrowse link 9 81,555,914 81,560,931 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Ip6k1 inositol hexakisphosphate kinase 1 JBrowse link 8 116,781,957 116,826,152 RGD:6480464
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:6480464
G Kng2 kininogen 2 JBrowse link 11 81,509,185 81,516,759 RGD:6480464
G Lep leptin JBrowse link 4 56,337,695 56,351,818 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6480464
G Mmp1 matrix metallopeptidase 1 JBrowse link 8 5,703,206 5,723,593 RGD:6480464
G Nefl neurofilament light JBrowse link 15 44,799,378 44,803,251 RGD:6480464
G Nefm neurofilament medium JBrowse link 15 44,855,307 44,860,604 RGD:6480464
G Nos1 nitric oxide synthase 1 JBrowse link 12 44,214,949 44,405,530 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Nppa natriuretic peptide A JBrowse link 5 164,808,407 164,809,716 RGD:6480464
G Nts neurotensin JBrowse link 7 44,111,594 44,120,998 RGD:6480464
G Plcb1 phospholipase C beta 1 JBrowse link 3 127,721,244 128,419,565 RGD:6480464
G Plcb3 phospholipase C beta 3 JBrowse link 1 222,207,887 222,224,993 RGD:6480464
G Plcd1 phospholipase C, delta 1 JBrowse link 8 127,753,514 127,782,070 RGD:6480464
G Plcg1 phospholipase C, gamma 1 JBrowse link 3 156,727,642 156,758,307 RGD:6480464
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B JBrowse link 10 86,303,727 86,312,770 RGD:6480464
G Prkca protein kinase C, alpha JBrowse link 10 96,186,509 96,585,168 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Rhoa ras homolog family member A JBrowse link 8 117,082,440 117,116,244 RGD:6480464
G Selp selectin P JBrowse link 13 82,428,914 82,464,629 RGD:6480464
G Src SRC proto-oncogene, non-receptor tyrosine kinase JBrowse link 3 153,547,807 153,595,643 RGD:6480464
G Tac1 tachykinin, precursor 1 JBrowse link 4 33,638,853 33,646,819 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 JBrowse link 5 3,783,247 3,836,485 RGD:6480464
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 JBrowse link 8 6,811,543 6,917,534 RGD:6480464
G Trpm8 transient receptor potential cation channel, subfamily M, member 8 JBrowse link 9 95,393,370 95,484,528 RGD:6480464
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 JBrowse link 10 59,799,123 59,824,208 RGD:6480464
G Vcam1 vascular cell adhesion molecule 1 JBrowse link 2 219,071,193 219,090,931 RGD:6480464
G Vim vimentin JBrowse link 17 80,882,715 80,891,200 RGD:6480464

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  CHEBI ontology 19679
    role 19623
      biological role 19621
        biochemical role 19147
          enzyme inhibitor 17984
            EC 3.* (hydrolase) inhibitor 17513
              EC 3.1.* (ester hydrolase) inhibitor 12782
                EC 3.1.4.* (phosphoric diester hydrolase) inhibitor 1318
                  EC 3.1.4.11 (phosphoinositide phospholipase C) inhibitor 61
                    U-73122 60
                    hispidospermidin 0
                    myo-inositol + 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.